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Yes, we can

Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

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Page 1: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Yes, we can

Page 2: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Certes…

Nephrol Dial Transplant. 2004 Nov;19(11):2778-83.

Page 3: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Mais !

Kidney International (2008) 73, 940–946

Page 4: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta
Page 5: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta
Page 6: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

R=0.45, P<0.005

Page 7: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Am J Kidney Dis. 2014 Oct;64(4):558-66

Page 8: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Au total !

NDT 2004 : 36 patients KI 2008 : 61 patients

AJKD 2014 : 95 patients

Dg tardif (3-4 semaines) Dg précoce (2 semaines)

Délai ttt = ?

Page 9: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Krishnan et al, Iran J Kidney Dis. 2015 Jan;9(1):3-13.

Page 10: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Rejet cellulaire NTIA

Page 11: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Le risque

Page 12: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

NTIA suspectée

Arrêt de tout médicament suspect

PBR

NTIA confirmée Origine médicamenteuse

suspectée

NTIA infirmée Origine infectieuse suspectée

Fibrose +++

Ttt symptomatique

Bolus MP 250-500mg 3j Relais PO 1mg/kg/j

Décroissance sur 1-2 mois

Cr ↔/↗ Cr ↘

Ttt symptomatique

Page 13: Yes, we can - WordPress.com · 1 ggs Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis 1 KherV, Arora P Rai PK. Sinahal M, Gupta

Merci