Yahya  Alzahrany, Mario GauthierIPR Symposium, Wednesday, May 2, 2012

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‐ Synthetic polymers can be categorized by their molecular architecturetheir molecular architecture

‐ Dendrigraft polymers belong to the dendriticl f ilpolymers family

-DONALD A TOMALIA 1 JEAN M J FRE´CHET2 2726 J POLYM SCI PART A:

2

DONALD A. TOMALIA,1 JEAN M. J. FRE CHET2, 2726 J. POLYM. SCI. PART A: POLYM. CHEM.: VOL. 40 (2002).

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• “Arborescent” refers to a tree like architecture• Arborescent  refers to a tree‐like architecture• Synthesis by a generation‐based scheme with cycles of substrate functionalization and graftinggrafting

G21) Functionalization 1) Functionalization

Li

G2)

2) Grafting*

2) Grafting

*LinearG0 G1

*

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= side chains (1)_

OHOH

styrene

+ (1)

OH

OH

OH OH

OH

OH

OH1-deprotection by

TBAF2 deprotonation

OHOH

OHOH

OH

OH

OHOH OHOH

OHG0PS

2- deprotonationMePh2CHK

OHOH

O-K+O-K+

O-K+O-K+O-K+

G0PSG1PS-OH

O-K+O-K+

O-K+O-K+ O-K+

glycidol acetal

4O-K+

O-K+

O-K+O-K+ O

-K+O-K+ O-K+core-shell copolymerafter deprotection alcoholate functionalities

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• Synthesis of linear and arborescent polystyreneSynthesis of linear and arborescent polystyrene substrates by cycles of acetylation and grafting

S th i f h d h bi h d l f ti li d• Synthesis of hydrophobic hydroxyl‐functionalized arborescent G0‐G3 cores using a bifunctionalinitiator

• Synthesis of glycidol acetalSynthesis of glycidol acetal• Growth of poly(glycidol acetal) chains from hydroxyl‐functionalized cores to form a shell

• Deprotection of the acetal to obtain a shell ofDeprotection of the acetal to obtain a shell of hydrophilic polyglycidol segments

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