Drug Pipeline Database

Developer Stage Status Code 1 Code 2 Generic name Trade name Collaborator Target Modality Disease Indication4SC P2 Active resminostat HDAC sm Oncology HCC, CRC, Hodgkin lymphoma

AbbVie Market Active adalimumab Humira TFN-alpha mAb AIID RAAbbVie P1 Active volociximab alpha5beta1 integrin mAb Oncology NSCLCAbbVie P1 Active ABT-957 calpain sm CNS ADAbbVie P1 Active enavatuzumab CD-266 (TWEAK receptor, Fn14) mAb Oncology solid tumorAbbVie P1 Active ABT-414 EGFR ADC Oncology solid tumors and glioblastomaAbbVie P1 Active ABT-981 IL-1 alpha and beta mAb OAAbbVie P1 Active ABT-494 JAK sm AIID RAAbbVie P1 Active ABT-413 S1P receptor sm AIID RAAbbVie P1 Active ABT-122 TNF alpha and IL-17 mAb AIID RAAbbVie P2 Active ABT-719 ZP1480 Zealand alpha MSH receptor sm Nephrology Acute kidney injuryAbbVie P2 Active ABT-126 alpha7 neuronal nicotinic receptor CNS ADAbbVie P2 Active BT-061 tregalizumab Biotest AG CD-4 mAb AIID RA, PsoriasisAbbVie P2 Active ABT-652 histamine H3 receptor sm OAAbbVie P2 Active GLPG0634 GLPG0634 Galaphagos JAK1 sm AIID RAAbbVie P2 Active ABT-288 neurotransmitter receptor CNS ADAbbVie P2 Active ABT-888 veliparib PARP sm Oncology various cancers including breastAbbVie P2 Active ABT-436 vasopressin receptor sm CNS depressionAbbVie P2 Active ABT-384 CNS ADAbbVie P2 Active ABT-652 CNS painAbbVie P3 Active Elagolix gonadotropin-releasing hormone (Gsm endometriosis, uterine fibroidsAbbVie P3 Active Daclizumab Zenapax IL-2R alpha (CD-25) mAb Oncology MMAbbVie P3 Active Levodopa/carbidopa sm CNS PDAbbVie P3 Active ABT-450/r+ABT-267+ABT-333 Enanta sm Infection HCV genotype 1

AbGenomics P1 Active AbGn-7 mAb Oncology solid tumorAbide Dis Celgene serine hydrolase smAblynx P1 Active ALX-0141 RANKL nanobody OncologyAblynx P1 Active ALX-0171 RSV nanobody Infection RSVAblynx P1 Active ATN-103 ozoralizumab TNF-α nanobody OncologyAblynx P2 Active ALX-0962 IgE nanobody AIID AllergyAblynx P2 Active ALX-0061 AbbVie IL-6 nanobody AIID RAAblynx P2 Active ALX-0081 ALX-0681 caplacizumab vWF nanobody

AC Immune P1 Active ACI-35 Tau protein mAb CNS ADAC Immune P2 Active ACI-24 Abeta mAb CNS ADAC Immune PC Active Morphomer Abeta sm CNS ADAC Immune PC Active Tau program Genentech Tau sm CNS ADAcademics P1 Active methyl jasmonate Hexokinase II sm Oncology skinAcceleron P2 Terminated ACE-031 Shire Myostatin sm Rare disease DMDAcceleron P2 Active ACE-011 sotatercept Celgene Activin receptor type IIA fusion protein Nephrology anemiaAcceleron P2 Active ACE-041 dalantercept Celgene ALK1(activin receptor-like kinase) fusion protein Oncology solid tumors

ACEA Bioscienes PC Active AC-0025 Btk sm AIID RA, ACEA Bioscienes PC Active AC-0010 EGFR tyrosine kinase sm Oncology

AcelRx P2 Active ARX-01 sufentanil Grunenthal sm CNS Post-op painACEO PC Active AV-380 GDF-15 mAb Oncology Cachexia

Acetylon P1 Active ACY-1215 ricolinostat Celgene HDAC6 sm Oncology MMActinium P2 Active M195 mAb Actimab-A CD-33 mAb Oncology AMLActinium P2 Active Iomab-B CD-45 mAb Oncology AMLActinium P2 Active milatuzumab-dox CD-74 ADC Oncology MMActinium PC Active Emab-SN-38 CD-22 ADC Oncology lymphoma

Active Biotech P3 Active ABR-217620 naptumonmab estafenatox 5T4 mAb? Oncology RCCActoGenix P2 Active AG013 Trefoil factor peptide(TFF) peptide Oncology ulcerative oral mucositis

Acucela P3 Terminated rebamipide sm Opthalmology dry eyeAcucela P1 Active OPA-6566 Adenosine A2a receptor sm Opthalmology GlaucomaAcucela P2/3 Active ACU-4429 emixustat sm Opthalmology Dry AMDAddex Dis Active GLP1 receptor sm Diabetes T2DMAddex Dis Active mGluR2 sm CNS AD, depressionAddex Dis Active ADX88178 mGluR4 sm CNS PDAddex Dis Active mGluR7 sm CNS Anxiety, depression, PTSDAddex Dis Active TNFR1 sm AIIDAddex Dis Active TrkA - BDNF sm CNS HDAddex P1 Active GABA-B receptor sm CNS chronic OA pain, overactive bladdAddex P2 Active ADX71149 Janssen returned imGluR2 sm CNS schizophrenia, anxietyAddex P2 Active ADX48621 dipraglurant mGluR5 sm CNS PD levodopa-induced dyskinesia

Adenium biotech PC Active AP114 plectasin variant C. difficile peptide Infection G(-) C. difficileAdenium biotech PC Active AA139 arenicin-3 G(-) peptide infection G(-) P.aeruginosa A. baummannii etc

Adrea P1 Active RDEA3170 AstraZeneca URAT1 sm GoutAdrea P2 Active BAY 86-9766 RDEA119 MEK sm Oncology liver, pancreatic cancerAdrea P3 Active RDEA594 lesinurad AstraZeneca URAT1 sm Gout

Aegerion Reg Active lomitapide microsomal tryglyceride transfer prsm CVSAeterna Zentaris GmbHP1 Active AEZS-112 tubulin-binder+topo II inhibitor sm OncologyAeterna Zentaris GmbHP3 Active AZES-108 LHRN-receptor sm Oncology , bladder cancerAeterna Zentaris GmbHP3 Active AEZS-130 macimorelin ghrelin receptor agonist sm Oncology cacner cachexia, AGHDAeterna Zentaris GmbHPC Active AEZS-138 GnRH receptor sm Oncology

Afferent P2 Active AF-219 purinoceptor P2X3 sm OAAffinium P2 Active AFN-1252 FabI sm Infection Gram(+) antibiotics

Affris P1 Active PD01A alpha synuclein peptide CNS Parkinson's diseaseAffris P2 Active AD02 beta-amyloid peptide CNS ADAffris PC Active CETP peptide CVS artherosclerosis

Agensys P1 Active AGS-16M8F Astellas AGS-16 ADC Oncology liver cancer, renal cancerAgensys P1 Active AGS-22ME Astellas Nectin-4 ADC Oncology solid tumorAgensys P1(?) Active AGS-15E Astellas SLITRK6 ADC Oncology bladder cancerAgensys P2 Active Astellas PSCA mAb Oncology pancreatic cancerAgensys PC Active AGS67E Astellas CD-37 ADC Oncology pancreatic cancer

Agenus PC Active GITR agnoist mAb OncologyAgenus PC Active OX40 agonist mAb OncologyAgenus PC Active TIM-3 antagonist mAb OncologyAgenus PC Active LAG-3 antagonist mAb OncologyAgenus PC Active PD-1 antagoinist mAb OncologyAgenus PC Active CTLA-4 antagonist mAb OncologyAileron PC Active ALRN6924 p53-mdm2/mdmx sm OncologyAkebia P2 Active AKB-6548 HIF prolyl hydroxylase sm Nephrology CKDAlexion Market Active eculizumab Soliris compement protein C5 mAb Rare disease paroxysmal nocturn hemoglobinuriaAlexion Market Active eculizumab Soliris Complement system protein C5 mAb Rare disease Paroxysmal nocturnal hemoglobinuriaAlexion P2 Active ALXN6000 samalizumab CD-200 mAb Oncology leukemiaAlgiax PC Active AP-325 dehyroorotate dehydrogenase sm CNS neuropahtic painAlios P1 Active AL-8112 RSV sm Infection RSVAlios P1 Active AL-335 HCV sm Infection HCVAlios P2 Active AL-8176 RSV sm Infection RSVAllon P2 Active davunetide sm CNS ADAllos Market Active pralatrexate Folotyn antifolate sm Oncology peripheral T-cell lymphoma

Alnylam P1 Active ALN-PCS Tekmira PCSK-9 NAT CVS hypercholesterolemiaAlnylam P2 Active ALN-VSP Ascletis KSP+VEGF NAT Oncology liver cancerAlnylam P2 Active ALN-TTR02 patisiran Genzyme TTR(transhyretin) NAT TTR-mediated amyloidosisAlnylam P3 Active ALN-RSV01 Kyowa Hakko KirinNucleoapsid N gene of RSV genomi NAT Infection RSVAlnylam PC Active ALN-AT3 AT(antithrombin) NAT hemophilia and rare bleeding disorders

Altor BioScience P3 Active ALT-836 mAb Oncology cancerAmbit P1 Active AC480 HER (pan-HER) sm Oncology breast, brain, lungAmbit P1 Active AC410 JAK2 sm AIIDAmbit P2 Active AC220 quizartinib Flt3=CD135 sm Oncology AMLAmbit PC Active AC708 CSF1R sm AIID and OncoloActiveAmbit PC Active CEP-32496 Teva Braf sm Oncology melanoma and othersAmgen Dis Active glucokinase-GKRP sm DiabetesAmgen Market Active panitumumab Vectibix EGFR mAb Oncology CRCAmgen Market Active anakinra Kineret IL-1 receptor sm AIID RAAmgen Market Active denosumab Prolia, Xgeva RANK ligand mAb Oncology bone metastasis, postmenopausal osteoporosisAmgen P1 Active AMG 780 angiopoietin mAb OncologyAmgen P1 Active AMG 900 Aurora A, B, C kinase sm OncologyAmgen P1 Active AMG 557 AstraZeneca B7RP-1(B7 related protein) mAb AIID Systemic lupus erythematosusAmgen P1 Active AMG 820 c-FMS mAb Oncology cancersAmgen P1 Active AMG 729 CD-19/CD-32b mAb AIID SLE, RAAmgen P1 Active AMG 172 CD-70 ADC Oncology RCCAmgen P1 Active AMG 334 CGRP(Calcitonin Gene-related peptimAb CNS migraineAmgen P1 Active AMG 208 cMet sm OncologyAmgen P1 Active AMG 337 cMet sm OncologyAmgen P1 Active AMG-595 EGFRvIII ADC Oncology GlioblastomaAmgen P1 Active AMG 110 EpCAM mAb Oncology

Amgen P1 Active AMG 232 MT201 adecatumumab Merck-Serono EpCAM + CD-3 bispecific mAbOncology breast, prostate etcAmgen P1 Active AMG 139 AstraZeneca IL-23 mAb AIID Crohn's diseaseAmgen P1 Active AMG 811 interferon gamma mAb AIID Systemic lupus erythematosusAmgen P1 Active AMG 319 PI3K delta sm Oncology Hematologic malignanciesAmgen P1 Active AMG 158 AstraZeneca TSLP(thymic stromal lymphopoietinmAb Respiratory asthmaAmgen P1 Active AMG 876 fusion protein Diabetes T2DMAmgen P1 Active BAY 20-10112 Bayer mAb Oncology solid tumorAmgen P1 Active AMG 357 sm AIIDAmgen P2 Active AMG 181 AstraZeneca alpha4beta7 integrin mAb AIID inflammatory bowel diseaseAmgen P2 Active CK-1827452 omecamtive mecarbil Cytokinetics cardiac myosin sm CVS ventricular systolic heart failureAmgen P2 Active AMG 103 blinatumomab CD-19/CD-3 bispecific mAbOncology ALL (acute lymphoblastic leukemia), NHLAmgen P2 Active AMG 151 ARRY-403 Array Glucokinase sm Diabetes T2DMAmgen P2 Active AMG 747 GlyT-1 (glycine transporter type-1) sm CNS schizophreniaAmgen P2 Active AMG 167 romosozumab UCB sclerostin mAb bone-related conditionsAmgen P3 Active AMG 416 KAI-4169 KAI PharmaceuticaCaSR peptide Nephrology hyperparathyroidismAmgen P3 Active cinacalcet Sensipar/Mimpara CaSR sm Nephrology post renal transplantAmgen P3 Active panitumumab Vectibix EGF receptor mAb Oncology CRCAmgen P3 Active rilotumumab hepatocyte growth factor/scatter famAb Oncology gastric cacnerAmgen P3 Active AMG 827 brodalumab AstraZeneca IL-17 mAb AIID PsoriasisAmgen P3 Active denosumab Prolia RANK mAb Glucocorticoid-induced osteoporosisAmgen P3 Active denosumab Prolia RANK mAb Male osteoporosisAmgen P3 Active AMG 785 romosozumab UCB sclerostin mAb Postmenoposal osteoporosisAmgen P3 Active AMG 386 trebananib Tie2 receptor/Ang1,2 Peptibody Oncology Ovarian cancerAmgen P3 Active laherparepvec Talimogene Oncolytics Oncology MelanomaAmgen Registration Active AMG 145 evolocumab PCSK-9 mAb CVS HyperlipidemiaAmicus P3 Active migalastat HCL Amigal GSK collaboration terminated biologics Rare disease Fabry disease

Amplimmune P1 Active AMP-224 GSK PD-1 & B7 fusion protein Oncology cancer and chronic infectionAmplimmune P1 Active AMP-514 AZ acquired Ampl PD-1 mAb OncologyAmplimmune PC Active AMP-110 Daiichi Sankyo Th1 & Th17 balance AIID

AmpliPhi PC Active AmpliPhage-001 P. aeruginosa biologics Infection P. aeruginosa in CFAmpliPhi PC Active AmpliPhage-002 US Army S. aureus biologics Infection S. aureusAmpliPhi PC Active AmpliPhage-004 C. difficile biologics Infection C. difficileAnacor P2 Active AN2728 PDE4 sm Dermatology Atopic dermatitisAnacor PC Active AN3365 G(-) pathogen sm Infection G(-) infectionAnacor Registration Active AN2690 tavanorole aminoacyl-t-RNA synthetase sm Infection Onychomycosis

Anaptysbio PC Active ANB012 ActRIIb mAb muscle wasting disordersAnaptysbio PC Active ANB004 IL-17 mAb AIIDAnaptysbio PC Active LAG-3 mAb OncologyAnaptysbio PC Active TESARO PD-1 mAb OncologyAnaptysbio PC Active TIM-3 mAb OncologyAngiochem P2 Active ANG 1005 LRP-1 peptide Oncology brain cancerAngiochem PC Active ANG 2002 LRP-1 peptide CNS painAngiochem PC Active ANG 4043 LRP-1 Her2 mAb Oncology breast cancer to brain metastatis

AnonOx P1 Active CD-134 mAb Oncology prostate cancerAntisense Pharma P2 Active AP12009 trabedersen TGF-beta2 NAT Oncology melanoma, pancreatic cancer, CRC

Aphios P2 Active APH-0703 protein kinase C sm CNS ADAphton P2 Active IGN-101 edrecolomab EpCAM vaccine Oncology breast, prostate, etc

Aprea AB P2 Active APR-246 p53 (wild and mutant) sm OncologyArcher P1 Active ARC029 nilvadipine sm CNS ADArcher P1 Active ARC031 sm CNS ADArdelyx P2 Active RDX5791 NHE3 sm Nephrology CDK, ESRD/HD, HF, irritable bowel syndromeArdelyx PC Active RDX002 NaP2b sm Nephrology CDK, ESRD/HD, HF, irritable bowel syndromeArdelyx PC Active RDX009 TGR5 agonist sm Diabetes T2DMArdelyx PC Active RDX013 TGR5 agonist sm Diabetes T2DMArena P1 Active APD811 prostacyclin (IP) receptor (PGI2) sm CVS pulmonary Arterial Hypertension (PAH)Arena P1 Active temanogrel Ildong serotonin 2A receptor 5HTA2 sm CVS thrombotic diseaseArena P1 Active APD334 sphingosin-1-phosphate receptor 1 sm AIID RA, MS etcArena PC Active APD668 APD597 Janssen GPR119 sm Diabetes T2DMArena PC Active APD371 cannabinoid 2 (CB2) receptor sm CNS pain

arGen-X P1 Active ARGX-111 cMet mAb Oncology solid tumorarGen-X P2 Active ARGX-110 CD-70 mAb Oncology HematologyarGen-X PC Active ARGX-113 IL-22R mAb Dermatology Atopic dermatitisarGen-X PC Active IL6 mAb AIIDarGen-X PC Active Nav1.7 mAb CNS neuropathic painarGen-X PC Active ARGX-109 RcRn mAb AIID autoimmunity

Argos P1 Active AGS-009 interferon alpha mAb AIID SLE (lupus)Argos P1 Active AGS-009 mAb AIID systemic lupus erythematosusArgos P2 Active AGS-004 NAT Infection HIVArgos P3 Active AGS-003 NAT Oncology mRCCArgos PC Active sCD83 sCD83 Biologics AIID transplantation etcAriad Market Active ponatinib Iclusig BCR-ABL, BCR-ABLT315I, etc sm Oncology CML, Ph (+) ALLAriad P2 Active AP26113 ALK+EGFRTK sm Oncology NSCLC, neuroblastomaArray P2 Active ARRY-380 HER2 sm OncologyArray P2 Active ARRY-797 p38 MAPK sm OAArray PC Active ARRY-470, ARRY-523, ARRY-772 Foundation MedicNRTK1 (TRK-A) sm Oncology NSCLC

Arsanis PC Active Staph. Aureus mAb Infection S. aureus infrectionAstellas Reg Terminated ASP4130 tivozanib AVEO, right will b VEGFR 1,2 and 3 sm Oncology RCCAstellas Market Active MDV3100 enzalutamide Xtandi androgen receptor sm Oncology metastatic castration-resistant prostate cancerAstellas Market Active ASP1941 ipragliflozin Suglat Kotobuki SGLT2 sm Diabetes T2DMAstellas P1 Active ASP3026 ALK sm Oncology NSCLC, neuroblastomaAstellas P1 Active ASP8477 CB2 or TrkA or FAAH sm CNS neuropathic painAstellas P1 Active ASP9226 CB2 or TrkA or FAAH sm CNS neuropathic painAstellas P1 Active ASP2408 CTLA4 biologics AIID RAAstellas P1 Active ASG-22ME Seattle Genetics Nectin-4 ADC OncologyAstellas P1 Active AGS-5ME Seattle Genetics SCL44A4 ADC Oncology pancreatic cancerAstellas P1 Active AGS-16M8F ADC Oncology

Astellas P1 Active AGS-16C3F ADC OncologyAstellas P1 Active ASP0777 sm CNS ADAstellas P1 Active ASP0306 sm Metabolic disor lower urinary tract syndrome Astellas P1 Active ASP4901 AKP-002 sm Metabolic disor lower urinary tract syndrome Astellas P1 Active ASP3026 sm OncologyAstellas P1 Active ASP6432 sm Metabolic disor lower urinary tract syndrome Astellas P1 Active ASP7991 sm Metabolic disor secondary hyperparathyroidismAstellas P1 Active ASP9853 sm OncologyAstellas P1 Active ASP8232 sm Nephrology Diabetic nephropathyAstellas P1 Active fidaxomicin Optimer sm Infection clostridium difficile associated hiarrheaAstellas P1 Active ASP3662 sm CNS ADAstellas P1 Active ASP2409 organ transplant rejectionAstellas P2 Active ASKP1240 Kyowa Hakko KirinCD-40 mAb AIID transplant rejectionAstellas P2 Active ASP1707 GnRH sm Oncology endometriosis, prostate cancerAstellas P2 Active ASP0456 linaclotide Ironwood guanylate cyclase Type-C receptor sm AIID irritable bowel syndromeAstellas P2 Active YM311 FG-2216 Fibrogen HIF prolyl hydroxylase sm Nephrology renal anemiaAstellas P2 Active ASP7487 OSI-906 linsitinib OSI IGF-1R tyrosine kinase sm Oncology ovarian, NSCLCAstellas P2 Active ASP015K JAK-3 sm AIID RAAstellas P2 Active YM155 sepantronium bromide survivin sm Oncology NHLAstellas P2 Active EB178 solifenacin/mirabegron sm urinary incontinenceAstellas P2 Active ASP3652 sm chronic prostatitis, chronic pelvic pain syndromeAstellas P3 Active ASP1517 FG-4592 roxadustat FibroGen HIF prolyl hydroxylase sm Nephrology CKD anemiaAstellas P3 Active YM905 solifenacin muscarine M3 receptor sm Oncology Overactive bladderAstellas P3 Active YM533 beraprost sodium Toray prostacyclin receptor sm Nephrology chronic renal failureAstellas P3 Active FK949E quetiapine AstraZeneca serotonin/dopamine sm CNS depressionAstellas P3 Active cetolizumab pegol UCB TNF-alpha mAb AIID RAAstellas P3 Active NGX-4010 capsaicin NeurogesX TRPV1 sm CNS peripheral diabetic neuropathyAstellas P3 Active isavuconazole Basilea sm Infection antifungalAstellas P3 Active ASP0113 VCL-CB01 Vical vaccine infection CMVAstellas Reg Active MDV3100 Xtandi Medivation androgen receptor sm Oncology prostate cancer,Astellas Reg Active FK463 micafungin sm Infection antifungalAstex P1 Active AT13148 PKB, Akt, p70S6 kinase sm Oncology

Astex/Otsuka Market Active decitabie Dacogen Eisai, Janssen DNMT sm Oncology AML, CMLAstex/Otsuka P1 Active ASTX727 decitabine+E7727 Eisai cytidine deaminase sm Oncology MDSAstex/Otsuka P2 Active AT7519 Novartis CDK sm Oncology MMAstex/Otsuka P2 Active SGI-110 DNMT sm Oncology MDS, AML, Ovarian, LiverAstex/Otsuka P2 Active AT13387 HSP90 sm Oncology GIST, prostate, LungAstex/Otsuka P2 Active AT9283 Jak/Aurora sm Oncology MMAstraZeneca n/a Terminated AZD4017 11 beta HSD 1 (hydroxysteroid deh sm Metabolic disor glaucomaAstraZeneca n/a Terminated AZD3514 androgen receptor sm Oncology prostate cancerAstraZeneca n/a Terminated AZD3839 beta secretase sm CNS ADAstraZeneca n/a Terminated AZD2423 CCR2 sm CNS neuropathic painAstraZeneca n/a Terminated AZD8931 EGFR, ErbB2 and ErbB3 sm Oncology breast cancer

AstraZeneca n/a Terminated MEDI-570 ICOS mAb AIID Systemic lupus erythematosusAstraZeneca n/a Terminated AZD1480 JAK2 Oncology solid tumorsAstraZeneca n/a Terminated AZD2820 melanocortin receptor peptide Metabolic disor ObesityAstraZeneca n/a Terminated AZD9773 CytoFab TNF-α mAb Infection severe sepsisAstraZeneca n/a Terminated AZD8683 Pulmagen Therapeutics sm Respiratory COPDAstraZeneca P1 Terminated AZD1446 alpha4 beta2 neuronal nicotinic recsm CNS ADAstraZeneca P1 Terminated MEDI7814 C5/C5a mAb Respiratory COPDAstraZeneca P1 Terminated MEDI4212 IgE mAb Respiratory asthmaAstraZeneca P1 Terminated MEDi5117 IL-6 mAb AIID RAAstraZeneca P1 Terminated ASZ8330 ARRY 424704 MEK sm Oncology solid tumorsAstraZeneca P1 Terminated MEDI-557 RSV mAb infection RSV for COPD/CHF)AstraZeneca P1 Terminated AZD7594 SGRM Respiratory COPDAstraZeneca P2 Terminated AZD3480 alpha4 beta2 neuronal nicotinic recsm CNS ADAstraZeneca P2 Terminated AZD5213 histamine-3 receptor sm CNS Tourette's syndrome, neuropathic painAstraZeneca P2 Terminated tralokinumab IL-13 mAb AIID UC, asthma/IPFAstraZeneca P2 Terminated AZD6765 NMDA receptor sm CNS depressionAstraZeneca P2 Terminated MEDI-575 PDGFR-alpha mAb Oncology NSCLCAstraZeneca P2 Terminated AZD5423 SGRM Respiratory COPDAstraZeneca P2 Terminated fostamatinib SYK sm Oncology hematological malignanciesAstraZeneca Dis Active GIP receptor mAbAstraZeneca Market Active Bydureon GLP1 receptor agonist Peptide Diabetes T2DMAstraZeneca Market Active Brilinta ADP receptor antagonist sm CVS PAD, MI, strokeAstraZeneca Market Active anastrozole Arimidex Aromatase sm Oncology advanced breast cancer in postmenopausal womenAstraZeneca Market Active gefitinib Iressa EGFR TK sm Oncology NSCLCAstraZeneca Market Active vandertanib Caprelsa, Zactima EGFRs, VEGFRs, RET etc sm Oncology Medullary thyroid cancerAstraZeneca Market Active fulvestrant Faslodex estrogen receptor sm Oncology hormone receptor positive m Breast cancerAstraZeneca Market Active tamoxifen Nolvadex estrogen receptor sm Oncology Breast cancerAstraZeneca Market Active goserelin Zoladex gonadotropin-releasing hormone resm(peptide) Oncology advanced prostate cancerAstraZeneca Market Active saxagliptin Onglyza DPP-4 sm Diabetes T2DMAstraZeneca Market Active palivizumab Synagis RSV protein mAb Infection RSV(Respiratory syncytial virus)AstraZeneca Market Active BMS-512148 dapagliflozin/metf Xigduo SGLT-2/Metformin FDC sm Diabetes T2DMAstraZeneca Market Active dapagliflozin Forxiga BMS SGLT2 sm Diabetes T2DMAstraZeneca P1 Active AZD8186 PI3K beta sm Oncology hematological malignanciesAstraZeneca P1 Active AZD6378 ATR sm Oncoloyg CLL, head&neckAstraZeneca P1 Active AZD5363 AKT sm Oncology solid tumorsAstraZeneca P1 Active MEDI-3617 angiopoietin2 mAb Oncology solid tumorsAstraZeneca P1 Active AZD6423 NMDA receptor sm CNS suicidal ideationAstraZeneca P1 Active MEDI5872 B7RP-1(B7 related protein) mAb AIID Systemic lupus erythematosusAstraZeneca P1 Active ATM AVI beta lactamase/cepha infection serious bacterial infectionAstraZeneca P1 Active AZD3293 beta secretase sm CNS ADAstraZeneca P1 Active MEDI6469 CD-134 mAb Oncology solid tumorsAstraZeneca P1 Active moxetumomab pasudotox CD-22 ADC Oncology hematological malignanciesAstraZeneca P1 Active MEDI-565 CEA bispecific mAbOncology solid tumors

AstraZeneca P1 Active AZD6094 volitinib cMet sm Oncology solid tumorsAstraZeneca P1 Active MEDI0639 DDL-4 mAb Oncology solid tumorsAstraZeneca P1 Active MEDI0680 AMP-514 PD-1 mAb Oncology solid tumorsAstraZeneca P1 Active MEDI-565 CEA mAb Oncology solid tumorsAstraZeneca P1 Active AZD9291 EGFR TK sm Oncology NSCLC, RCC, CRC, GMBAstraZeneca P1 Active NEDI2070 IL-23 mAb AIID Crohn's diseaseAstraZeneca P1 Active MEDI-550 influenza vaccine infection influenzaAstraZeneca P1 Active MEDI4736 PD-L1 mAb Oncology solid tumorsAstraZeneca P1 Active MEDI4736+dabrafenib+trametinib PD-L1, BRAF+MEK mAb+sm Oncology melanomaAstraZeneca P1 Active MEDI4736+tremelimumab PD-L1, CTLA4 mAb Oncology solid tumorsAstraZeneca P1 Active AZD1208 PIM kinase sm Oncology hematological malignanciesAstraZeneca P1 Active MEDI-559 RSV vaccine infection RSVAstraZeneca P1 Active AZD9150 STAT3 Oncology hematological malignanciesAstraZeneca P1 Active AZD8848 TLR-7 Respiratory asthmaAstraZeneca P1 Active MEDI9929 TSLP(thymic stromal lymphopoietinmAb Respiratory AsthmaAstraZeneca P1 Active MEDI4893 Staph alpha toxin YTE mAb Infection HAP, S.aureusAstraZeneca P1 Active MEDI9287 H7N9 vaccine vaccine Infection H7N9 fluAstraZeneca P1 Active AZD1419 TLR9 sm Respiratory AsthmaAstraZeneca P1 Active AZD4721 CXCR2 sm Respiratory COPDAstraZeneca P1 Active AZD7624 ip38i sm Respiratory COPDAstraZeneca P1 Active PT010 LAMA/LABA ICS sm Respiratory COPDAstraZeneca P2 Active AZD1722 RDX5791 tenapanor Ardelyx NHE3 (sodium transport) sm Nephrology IBS, end-stage renal diseaseAstraZeneca P2 Active RDEA3170 URAT1 sm GoutAstraZeneca P2 Active AZD6244 ARRY-142886 selumetinib MEK1 sm Oncology solid tumorsAstraZeneca P2 Active AZD1775 Wee-1 inhibitor sm Oncology ovarian cancerAstraZeneca P2 Active MEDI-551 CD-19 mAb AIID MSAstraZeneca P2 Active AZS2014 TOR kinase sm Oncology solid tumorsAstraZeneca P2 Active MEDI-7183 alpha4beta7 integrin mAb AIID UC, Crohn's diseaseAstraZeneca P2 Active CXL beta lactamase/cepha sm infection MRSAAstraZeneca P2 Active MEDI-551 CD-19 mAb Oncology hematological malignanciesAstraZeneca P2 Active tremelimumab CTLA4 mAb Oncology mesotheliomaAstraZeneca P2 Active AZD5069 CXCR2 Respiratory 1208AstraZeneca P2 Active AZD4547 EGFR tyrosine kinase sm Oncology solid tumorsAstraZeneca P2 Active mavrilimumab GM-CSF R mAb AIID RAAstraZeneca P2 Active MEDI-573 IGF mAb Oncology MBCAstraZeneca P2 Active MEDI-8968 IL-1R mAb Respiratory COPDAstraZeneca P2 Active beralizumab IL-5 R mAb Respiratory Asthma, COPDAstraZeneca P2 Active MEDI-545 sifalimumab interferon alpha mAb AIID Systemic lupus erythematosusAstraZeneca P2 Active MEDI-546 MDX-1333 interferon alpha R 1 mAb AIID Systemic lupus erythematosusAstraZeneca P2 Active AZD2115 MABA Respiratory COPDAstraZeneca P2 Active AZD3241 myeloperoxidase(MPO) sm CNS PDAstraZeneca P2 Active AZD5847 oxazolidinone sm infection turberculosisAstraZeneca P2 Active AZD1722 NHE3 inhibitor sm Nephrology ESRD-Pi, CKD with T2DM, ESRD-fluid retension

AstraZeneca P2 Active AZD4901 NK3 sm Oncology polycystic ovarian syndromeAstraZeneca P2 Active CXL BLI/cepha sm Infection MRSAAstraZeneca P2 Active mavrilimumab GM-CSFR mAb AIID RAAstraZeneca P3 Active AZD6244 ARRY-142886 selumetinib MEK sm Oncology solid tumorsAstraZeneca P3 Active lesinurad Adrea Bioscience (URAT1 sm goatAstraZeneca P3 Active Caprelsa VEGFR/EGFR tyrosine kinase sm Oncology medullary thyroid cancerAstraZeneca P3 Active AZD2171 cediranib Recentin VEGFRs sm Oncology NSCLC, RCC, CRC, GMBAstraZeneca P3 Active benralizumab IL-5R mAb Respiratory AsthmaAstraZeneca P3 Active brodalumab IL-17R mAb AIID psoriasisAstraZeneca Registration Active linaclotide GC-C receptor agonist peptide Irritable bowel syndromeAstraZeneca Registration Active saxagliptin/dapagliflozin DPP-4/SGLT2 FDC sm Diabetes T2DMAstraZeneca Registration Active metreleptin leptin analogue peptide Metabolic disor lipodystrophyAstraZeneca Registration Active AZD2281 olaparib KuDos PARP sm Oncology ovarian, breast cancer, gastric cancerAstraZeneca Registration Active NKTR-118 naloxegol mu-opiod receptor sm opiod-induced constipationAstraZeneca Registration Active moxetumomab pasudotox CD022 ADC Oncology hairy cell leukemia

Atara P1 Active STM 434 Activin sm Oncology ovarian cancerAtara P2 Active PINTA 745 Myostatin mAb Nephrology CKDAtara PC Active MINA 842 Myostatin mAb Oncology Cachexia in cancer

Atlantic Healthcare P3 Active Alicaforsen ICAM-1 NAT AIID IBDAurigene Dis Active NAMPT sm OncologyAurigene Dis Active Immune checkpoints OncologyAurigene Dis Active Bet bromodomain sm OncologyAurigene Dis Active EZH2 sm OncologyAurigene Dis Active IRAK4/2 sm OncologyAurigene Dis Active BTK sm AIIDAurigene Dis Active ROR gamma sm AIIDAurigene PC Active SCD-1 sm AIIDAurigene PC Active matriptase sm AIIDAurigene PC Active PD-1 peptide InfectionAurigene PC Active FabI sm InfectionAuspex P2 Active SD-254 venlafaxine Effexor selective serotonin-norepinephrine sm CNSAuspex P3 Active SD-809 dutetrabenazine VMAT-2 (vesicular monoamine transsm CNS Chorea of PD (abnormal involuntAuspex PC Active SD-560 pirfenidone sm Fibrosis idiopathic pulmonary fibrosisAuspex PC Active SD-970 ticagrelor ADP receptor antagonist sm CVS acute coronary syndromeAuspex PC Active SD-900 tofacitinib JAK sm AIID RA

Autifony P1 Active Kv3 sm CNS hearing disorderAutifony PC Active Kv3 sm CNS Schizophrenia

AVEO P2 Terminated AV-299 ficlatuzumab HGF/scatter factor mAb Oncology glioblastomaAVEO P1 Active AV-203 Biogen Idec ErbB3 mAb OncologyAvexin P2 Active AVX001 Ivalpha PLA2 sm AIID psoriasis, RA

Avineuro P2 Active AVM 101 5-HT6 receptor sm CNS AD

Balance P2 Active BTD-001 sm CNS cognitive impairment of Down syBasilea P1 Active BAL101553 microtubule sm Oncology

Basilea P1 Active BAL30072 G(-) pathogen sm Infection G(-) infection (A. baummannii, P.aeruginosa)Basilea P3 Active Isavuconazole sm Infection antifungalBasilea PC Active BAL0105277 PDE4 sm IID psoriasis, COPDBasilea Registration Active ceftobiprole anti-MRSA sm Infection MRSABayer Market Active sorafenib Nexavar c-Raf, B-rat, Kit etc sm Oncology HCC, RCCBayer Market Active regorafenib Stivarga VEFGR1/2/3, BCR-ABL, B-raf sm Oncology CRCBayer Market Active ziv-aflibercept Zaltrap Regeneron VEGF fusion protein Oncology mCRCBayer Market Active BAY 73-4506 regorafenib Stivarga Onyx VEGFR2, Tie2 sm Oncology CRC, GIST, liver cancer etcBayer Market Active radium Ra 223 dichXofigo Oncology treatment of prostate cancer with bone metastasisBayer P1 Active BAY-79-4620 CA6 ADC Oncology lymphomaBayer P1 Active BAY 79-4620 Carbonic anhydrase 9 mAb Oncology solid tumorBayer P1 Active Fzd7 vantictumab human Frizzled receptors mAb Oncology solid tumorBayer P2 Active BAY 80-6946 copanlisib PI3K sm Oncology LymphomaBayer P2 Active BAY 85-3934 molidustat HIF prolyl hydroxylase sm Nephrology anemia (CKD)Bayer P2 Active BAY-94-8862 finerenone mineralocorticoid receptor antagonism CVS chronic heart failure, diabetic nephropathyBayer P2 Active BAY-1021189 soluble guanylate cyclase sm CVS chronic heart failureBayer P2 Active BAY 80-6946 PI3K alpha and delta sm OncologyBayer P3 Active BAY 1002670 sPRM progesterone receptor uterine fibroidsBayer PC Active BAY 94-9343 ImmunoGen mesothelin ADC Oncology ovarian and pancreatic cancerBayer Registration Active BAY 63-2521 riociguat Adempas soluble guanylate cyclase sm CVS pulmonary arterial hypertensionBayer Active PTK787 vatalanib Novartis PDGFRs, VEGFRs, PDGFR beta, cKit sm Oncology mCRC

BI P2 Terminated sibrotuzumab FAP mAb Oncology Colorectal cancerBI Market Active meloxicam Mobic COX-2 sm OABI Market Active BIBW2992 afatinib Gilotrif EGFR TK sm Oncology NSCLC, BC, HNSCC, BI Market Active dabigatran etexilatPRADAXA thrombin sm CVS SPAF, VTBI Market Active linagliptin Tradjenta peptide Diabetes T2DMBI Market Active empagliflozin Jardiance Eli Lilly SGLT2 sm Diabetes T2DMBI P1 Active BI-836845 IGF mAb Oncology solid tumorBI P1 Active BI-655075 mAb CVS blood coagulation disordersBI P1 Active XmAb mAb Oncology cancerBI P2 Active nintedanib multi kinases sm Oncology RCC, HCCBI P3 Active volasertib PLK1 sm OncologyBI Registration Active BIBF 1120 nintedanib triple angiokinase inhibitor sm Oncology oncology and IPF

BIND Therapeutics P2 Active BIND-014 docetaxel PSMA sm Oncology NSCLCBioClin P2 Active B-701 Fibroblast Growth Factor receptor mAb Oncology

BiogenIdec P3 Terminated KNS-760704 dexpramipexole Knopp Biosciencesmitochondrial function sm CNS ALS(Lou Gehrig)BiogenIdec Dis Active Nrf2-KEAP1 sm AIIDBiogenIdec Market Active natalizumab Tysabri alpha4 integrin mAb AIID MS relapsing-remittingBiogenIdec Market Active daclizumab Zenapax Abbott IL-2 R mAb AIID MS, relapsing formBiogenIdec Market Active BG-12 dimethylfumarate Tecfidera Fumapharm Nrf2 sm AIID MS, relapsing formBiogenIdec P1 Active BIIB037 Abeta mAb CNS ADBiogenIdec P1 Active CD40L CD-154 mAb AIID Systemic lupus erythematosusBiogenIdec P1 Active BIIB015 Cripto ADC Oncology cancers

BiogenIdec P1 Active SMNRX ISIS n/a NAT Spinal muscluar atrophyBiogenIdec P1 Active Neublastin Neublastin CNS Neuropathic painBiogenIdec P2 Active M-200 velociximab alpha5 beta1 mAb OncologyBiogenIdec P2 Active galiximab CD-80 mAb Oncology NHLBiogenIdec P2 Active BIIB033 Anti-Lingo LINGO 1 mAb AIID MSBiogenIdec P2 Active STX-100 n/a mAb idiopathic pulmonary fibrosis(IPF)BiogenIdec P2 Active BIIB023 TWEAK mAb AIID Lupus nephritisBiogenIdec P3 Active GA101 obinutuzumab Genentech CD-20 mAb Oncology CLL(chronic lympocytic leukemia), NHLBiogenIdec P3 Active Itoluzumab CD-6 mAb AIID Plaque psoriasisbioinvent P1 Active BI-505 ICAM-1 mAb Oncology MMbioinvent P2 Active BI-204 RG7418 oxLDL mAb CVS arherosclerosisBioLineRx P2 Active BL-8040 BKT140 CXCR4 sm Oncology NSCLC, CMLBiomarin P1 Active BMN-673 PARP sm Oncology

Bionomics Dis Active BNC375 NAChR receptor sm CNS ADBionomics P1 Active BNC210 IW-2143 sm CNS Anxiety, depressionBionomics P2 Active BNC105 sm Oncology renal, ovarial, mesotheliomaBionomics PC Active BNC101 LGR5 sm Oncology cancer stem cell, solid tumorsBionomics PC Active BNC102 sm Oncology cancer stem cells, solid tumorBionomics DIS Merck Nav1.7 sm CNS Neuropathic painBionomics PC Kv1.3 sm AIID Psoriasis, MS, RA

Biosceptre InternationalP1 nf-P2X2 mAb Oncology skin cancerBiotest P2 Active BT-062 indatuximab ravtansine CD-138(=SDC1) ADC Oncology MM

BMS ? Active NRT sm infection virologyBMS Dis Active TGR5 mAb Metabolic disorderBMS Market Active BMS-354825 dasatinib Sprycel Bcr-Abl tyrosine kinase, btk sm Oncology CMLBMS Market Active MDX-101 Ipilimumab Yervoy CTLA-4 mAb Oncology melanoma, squanoms NSCLC, prostate cancerBMS Market Active abatacept Orencia CTLA-4 mAb AIID autoimmuneBMS Market Active BMS-477118 saxagliptin AstraZeneca DPP-4 sm Diabetes T2DMBMS Market Active BMS-247550 ixabepilone Ixempra microtubule sm Oncology breast cancerBMS Market Active paclitaxel Taxol mitotic inhibitor sm Oncology AIDS-related Kaposi's carcomaBMS n/a Active Triple reuptake inhibitor CNSBMS P1 Active 11 beta HSD 1 (hydroxysteroid deh sm Metabolic disorderBMS P1 Active alpha7 nicotinic agonist CNSBMS P1 Active BMS-844203 CT-322 Anti-angiogenic AdnectinBMS P1 Active CCR1 sm AIIDBMS P1 Active CCR2/5 sm CVSBMS P1 Active urelumab CD-137 mAb OncologyBMS P1 Active Anti-CD40L CD-154(=CL-40L) mAb AIIDBMS P1 Active CD-28 mAb AIIDBMS P1 Active Anti-CD40 CD-40 mAb AIIDBMS P1 Active MDX-1203 CD-70 ADC Oncology NHLBMS P1 Active BMS-936564 CD-70 mAb OncologyBMS P1 Active BMS-936564 MDX-1338 CXCR4 mAb Oncology hematological malignancies and varios solid tumors

Onglyza

BMS P1 Active Factor Xia CVSBMS P1 Active Factor Xia CVSBMS P1 Active Anti-Fucosyl GM1 Fucosyl GM1 mAb Oncology Lung cancerBMS P1 Active gamma secretase sm CNS ADBMS P1 Active GPR119 sm Metabolic disorderBMS P1 Active GPR40 agonist GPR40 sm AIIDBMS P1 Active Ikur sm CVSBMS P1 Active IL-17/IL-23 mAb AIIDBMS P1 Active IL-21 denenicokin IL-21 mAb Oncology CancerBMS P1 Active IL-31 mAb AIIDBMS P1 Active clazakizumab IL-6 mAb AIIDBMS P1 Active IP-10 mAb AIIDBMS P1 Active JAK2 sm Oncology MPD(Myeloproliferative disorder)BMS P1 Active Anti-LAG3 LAG-3 mAb Oncology cancerBMS P1 Active LPA1 sm AIIDBMS P1 Active BMS-852927 XL041 LXR sm CVS hypercholesterolemiaBMS P1 Active BMS-241027 Microtubule stablizer sm CNS ADBMS P1 Active Myostatin Adnectin Myostatin Adnectin CNSBMS P1 Active Notch sm OncologyBMS P1 Active BMS-962476 PCSK-9 Adnectin CVSBMS P1 Active Anti-PD-L1 BM-S936559 MDX-1105 PD-L1 mAb infection virology (HIV)BMS P1 Active Anti-PD-L1 BM-S936559 MDX-1105 PD-L1 mAb Oncology cancerBMS P1 Active PEG-FGF21 PEG-FGF21 Metabolic disorderBMS P1 Active Relaxin CVSBMS P1 Active S1P1 sm AIIDBMS P2 Active BMS-901608 HuLuc63 elotuzumab Abbott CS-1 mAb Oncology MMBMS P2 Active BMS-986015 IPH2102 lirilumab Innate Pharma KIR mAb OncologyBMS P2 Active BMS-663068 n/a Infection HIVBMS P2 Active BMS-790052 DCV daclatasvir NS5A sm InfectionBMS P2 Active BMS-833923 XL139 SMO(Smoothened) sm Oncology leukemia and solid tumorsBMS P3 Active metreleptin Amylin Leptin peptide Diabetes diabetes,HypertriglyceridemiaBMS P3 Active BMS-650032 asunaprevir NS3 sm InfectionBMS PC Active MDX-1204 mesothelin ADC OncologyBMS Registration Active BMS-936558 MDX1106 nivolumab Opdivo Ono PD-1 mAb Oncology melanoma, sq NSCLC, Nsq NSCLC, RCCBMS Active Necitumumab EGFR mAbBMS Active Ambrx FGF Diabetes T2DM

Boston Biomedical P1 Active BBI503 other cancer stem cell kinase targetsm OncologyBoston Biomedical P3 Active BBI608 beta catenin sm Oncology colorectal cancer, ovarian, gastric cancer, melanoma

BrainCells P1 Active BCI-632 mGluR2/2 sm CNS depressionBrainCells P1 Active BCI-838 mGluR2/2 sm CNS depression

Cantargia AB Dis Active IL1RAP mAb Oncology myeloid leukemiaCarna Dis Active Btk sm Oncology hematology etcCarna Dis Active CDC7 sm Oncology

Carna Dis Active DYRK1a sm CNS ADCarna Dis Active TNIK sm Oncology Gastric cancerCelera Active CD-133 sm Oncology CRCCelgen Market Active FK228 FR901228 romidepsin Istodax Gloucester HDAC sm Oncology cutaneous T-cell lymphoma

Celgene Market Active CC-4047 pomalidomide Pomalyst angiogenesis sm Oncology multiple myelomaCelgene Market Active 5-azacitidine Vidaza DNMT sm Oncology AML, DNA methyltransferaseCelgene Market Active paclitaxel protein- Abraxane Abraxis Oncology NSCLSCelgene Market Active lenalidomide Revlimid sm Oncology mantile cell lymphomaCelgene P1 Active AVL-292 Avila Btk sm AIID, Oncology RACelgene P3 Active apremilast PDE-4 sm AIID Ankylosing spondylitis, proriasis, RA

Cell Therapeutics P3 Clinical hold tosedostat aminopeptidase sm Oncology AMLCell Therapeutics P1 Active CT-1578 JAK2/Flt-3/c-Fms sm AIID RACell Therapeutics P3 Active pacritinib JAK2 and FLT3 sm Oncology primary myelofibrosis

Celldex P1 Active CDX-301 FLT3 ligand biologics HSC transplatationCelldex P2 Active CDX-1127 CD-27 mAb Oncology breast cancer, melanomaCelldex P2 Active CDX-011 CR011-vcMMAE glembatumumab vedotin GPNMB(glycoprotein NMB) ADC Oncology breast cancer, melanomaCelldex P2 Active CDX-1401 NY-E8O-1 mAb Oncology solid tumorCelldex P3 Active CDX-110 rindopepimut EGFRvIII vaccine oncology glioblastomaCelldex PC Active CDX-301 soluble CR1 biologics renal diseaseCelldex PC Active CDX-014 Tim-1 ADC Oncology ovarian and RCC

Cellectis S.A PC Active UCART19 CD-19 Cell Oncology Chronic lymphocytic leukemia(CLL)Celphalon P3 Active CEP-701 Lestaurtinib FLT3, JAK2, TrkA, TrkB, TrkC sm Oncology AML, myeloproliferative disordersCempra P2 Active CEM-102 TAKSTA sodium fusidate sm Infection ABSSS, MRSACempra P3 Active CEM-101 solithromycin sm Infecrtion MRSA

Centrosepharma PC Active EDC3 CD-44 ADC Oncology cancerCentrosepharma PC Active EDC1 Dysadherin OncologyCentrosepharma Active EDC2 CD-147 ADC Oncology cancers

Cephalon Market Active SDX-105 bendamustine Treanda alkylating agent sm Oncology CLL and B-cell NHLCephalon P3 Active CEP-33237 hydrocodone sm OACerecore P2 Active CERC-301 MK-0657 Merck NR2 B sm CNS anti-depressantCerulean P2 Active CRLX101 HIF 1 alpha sm Oncology NSCLC, RCC

ChemoCentryx Dis Active CCR1 sm AIID RAChemoCentryx Dis Active CCR6 sm AIID RA, IBD etcChemoCentryx P1 Active CCX140 CCR2 receptor sm Nephrology diabetic neuropathyChemoCentryx PC Active CCX6239 CCR4 sm AIID aptoic dermatitis and asthmaChemoCentryx PC Active CCX507 CCR9 sm AIID Ulcerative colitisChemoCentryx PC Active CCX662 CXCR7 sm Oncology Brain cancer

Chiome Bioscience PC Active semaphorin mAb CNSChroma Therapeutics P2 Active CHR-2845 HDAC sm Oncology HCCChroma Therapeutics P2 Active CHR-3996 HDAC (Class I) sm Oncology MMChroma Therapeutics registration Active CHR-2797 tosedostat Cell Therapeutics aminopeptidase sm Oncology

Chugai P2 Active CH5424802 ALK sm Oncology NSCLC, neuroblastomaChugai P3 Active topoglifozin Sanofi, Kowa SGLT2 sm Diabetes T2DM

Cidara PC Active biafungin Seachaid Antifungal sm Infection anti-fungalCIMAB P3 Active racotumomab GM3 mAb Oncology NSCLC

CKD Market Active CKD-501 Lobeglitazone Dubie PPAR gamma sm Diabetes T2DMCKD Market Active CKD-501 Lobeglitazone Dubie PPAR gamma sm Diabetes T2DMCKD PC Active CKD-519 tubulin sm OncolgoyCKD PC1 Active CKD-581 sm Oncology

Cleave Biosciences P1 Active CB-5083 p97 pathway sm Oncology Multiple MyelomaClovis P1/2 Active CO-1686 EGFR TK (mutant) sm OncologyClovis P2 Active lucitanib FGFR 1/2 TKClovis P2 Active AG014699 CO-338 rucaparib PARP sm Oncology breast, ovarian cancer and solid tumors

Conatus P2 Active Emricasan caspase sm fibrosis post liver transplantCoNCERT P1 Active CTP-354 sm CNS spasticity associated with MSCoNCERT P1 Active AVP-786 Avanir sm CNS Neurologic and psychiatric disordersCoNCERT P1 Active CTP-730 Celgene sm AIID inflammatory diseaseCoNCERT P1 Active JZP-386 Jazz sm CNS narcolepsyCoNCERT P2 Active CTP-499 sm Nephrology Diabetic kidney diseaseCoNCERT PC Active C-10068 sm CNS pain and seizureCoNCERT PC Active deuterate ivacaftor sm Respiratory CF and COPD

Constellation Dis Active Genentech histone lysine methyltransferase (E sm OncologyConstellation P1 Active CPI-0610 Genentech BET(bromodomain extraterminal prsm Oncology

Convergence Pharma P1 Active CNV1061436 GSK sodium channels sm CNS epilepsy and bipolar disorderConvergence Pharma P2 Active CNV1014802 Nav1.7 sm CNS neuropathic painConvergence Pharma P2 Active CNV2197944 Cav2.2 sm CNS chronic pain

Covagen P1 Active COVA322 Mitsubishi TanabeTNF & IL-17A mAb AIID psoriasisCovagen PC Active COVA208 HER2 mAb(bispecificOncology breast cancer

CrystalGenomics Dis Active CG026864 KMO (Kynurenine 3-monooxygenassm CNS AD, PD, HDCrystalGenomics Dis Active Metalo beta-lactamase sm InfectionCrystalGenomics Dis Active PCSK-9 sm CVSCrystalGenomics Dis Active TNIK sm OncologyCrystalGenomics Dis Active UBA5 sm OncologyCrystalGenomics P2 Active CG400549 enoyl reductaseCrystalGenomics P2 Active CG200745 HDAC sm OncologyCrystalGenomics PC Active Aurora K sm Oncology myelodysplastic syndrome, MDSCrystalGenomics PC Active BTK sm OncologyCrystalGenomics PC Active kynurenine 3-monooxygenase (KMOsm CNS Huntington's disease, Alzheimer's diseaseCrystalGenomics registration Active CG100649 polmacoxib COX-2 sm OA

Cubist P2 Active AYX1 Adynxx sm CNS acute painCubist P3 Active CB-5945 bevenopran mu-opiod receptor sm opiod-induced constipationCubist P3 Active CB-315 surotomycin sm Infection clostridium difficile associated diarrhea

Curacell Biotech Market Active Carmustine Gliadel Wafer Alkylating agent sm Oncology brain cancerCureTech P2 Active CT-011 pidiluzumab PD-1 mAb Oncology mMelanoma, AML, mCRC, diffuse large B-cell lymphoma

Curis P1 Active CUDC-907 HDAC and PI3K sm Oncology lymphoma, MMCuris P1 Active CUDC-427 Genentech IAP (Inhibitor of Apoptosis Proteins) Oncology

Cytokinetics P2 Active CK-2127107 tirasemtiv Astellas skeletal muscle troponin complex sm ALS muscle weakness and fatigue.CytomX PC Active CTX-023 EGFR mAb OncologyCytomX PC Active CTX-023 gp130 mAb AIIDCytomX PC Active CTX-023 IL-6R mAb AIIDCytomX PC Active CTX-033 Jagged mAb(probody)OncologyCytomX PC Active Notch pathway targets mAb OncologyCytomX PC Active PD-L1 mAb OncologyCytomX PC Active CTX-023 VEGF mAb AIIDCytomX PC Active ADC OncologyCytRx P2 Active INNO-406 befetinib Lyn and Fyn kinase sm

Daewoong P2 DWP05195 TRPV1 sm CNS painDaiichiSankyo P1 Active U3-1565 BH-EGF mAb Oncology solid tumorDaiichiSankyo P1 Active DS-1442 CETP sm CVS dyslipidemiaDaiichiSankyo P1 Active PLX5622 FMS kinase sm AIID RADaiichiSankyo P1 Active DS-7309 Glucokinase sm Diabetes T2DMDaiichiSankyo P1 Active DS-8500 GPR119 sm Diabetes T2DMDaiichiSankyo P1 Active DS-2248 hsp90 sm Oncology solid tumorDaiichiSankyo P1 Active DS-3078 mTOR sm Oncology solid tumorDaiichiSankyo P1 Active DS-7113 hydromorphone opiod mu reeptor sm CNS narcotic analgesicDaiichiSankyo P1 Active DS-7423 PI3K+mTOR sm Oncology solid tumorDaiichiSankyo P1 Active CS-0777 S1P receptor sm AIID immunomodulatorDaiichiSankyo P1 Active DS-1040 TAFIa sm CVS Acute ischemic strokeDaiichiSankyo P1 Active CS-4771 TLR4 sm Infection sepsisDaiichiSankyo P1 Active U3-1565 mAb Oncology solid tumorDaiichiSankyo P2 Active DS-5565 alpha2 delta sm CNS painDaiichiSankyo P2 Active ASB17061 Chymase sm AIID atopic dermatitisDaiichiSankyo P2 Active CS-1008 tigatuzumab Death receptor 5 mAb Oncology breast,liver, ovarian, pancreatic cancerDaiichiSankyo P2 Active DS-7250 DGAT1 sm Diabetes T2DMDaiichiSankyo P2 Active PLX3397 Fms/Kit/Flt3 sm Oncology Glioblastoma, prostate, acute myeloid leukemiaDaiichiSankyo P2 Active CS-3150 MR sm CVS hypertensionDaiichiSankyo P3 Active CS-747 prasugrel anti-platelet sm CVS acure coronary syndromeDaiichiSankyo P3 Active ARQ 197 tivantinib cMet sm Oncology CRC, HCCDaiichiSankyo P3 Active DE-766 nimotuzumab EGFR mAb Oncology gastric, NSCLC, esophageal cancerDaiichiSankyo P3 Active DU-176b edoxaban Factor Xa sm CVS atrial fibrillation, venous thromboembolismDaiichiSankyo Reg Active CS-8958 laninamivir neuraminidase sm Infection influenza

Dainona PC Active CD-43 mAb Oncology AMLDebio Market Active triptorelin Trelstar Depot gonadotropin-releasing hormone resm(peptide) Oncology palliative treatment of advanced prostate cancerDebio P1 Active Debio 0932 hsp90 sm OncologyDebio P3 Active Debio 025 Novartis cyclophilin sm Infection HCVDebio PC Active Debio 0930 AMPK sm Metabolic disorderDebio PC Active Debio 1036 MIF sm AIIDDebio PC Active Debio 0826 notch pathway sm Oncology

Dendreon Market Active APC8015 sipuleucel-T Provenge cell therapy Oncology hormone refractory prostate cancer

Destiny P2 Active XF-73 Staphylococcal sm Infection Staphylococci including MRSADicerna P1 Active DCR-M1711(Myc) cMyc NATDicerna PC Active Androgen receptor NATDicerna PC Active beta-catenin NATDicerna PC Active HER2 NATDicerna PC Active HER3 NATDicerna PC Active HIF1alpha NATDicerna PC Active HIF2alpha NATDicerna PC Active Kyowa Hakko KirinKras NAT

Domainex Dis Active IKKe and TBK1 sm AIIDDomainex Dis Active KMT sm Oncology

Dompe P2 Active Repertaxin reparixin CXCR1 (=IL8RA) sm Oncology breast cancerDurata Registration Active dalbavancin reparixin sm Infection skin infection and MRSA

Eisai Market Active APD-356 lorcaserin Belviq Arena 5-HT2c receptor sm Metabolic disor obesityEisai Market Active T-614 iguratimod Careram sm AIID RAEisai Market Active E2090 zonisamide Zonegran sm CNS epilepsyEisai P2 Active E2609 BiogenIdec BACE sm CNS ADEisai P2 Active BAN2401 BioArctic Neurosc Abeta mAb CNS ADEisai P2 Active E7820 alpha 2 interin sm Oncology colorectal cancerEisai P2 Active MORAb-004 endosialin mAb Oncology CRC, melanomaEisai P2 Active E7272 denileukin diftitox Ontak IL-2 receptor biologics Oncology melanomaEisai P2 Active E6201 MEK 1 sm AIID psoriasisEisai P2 Active MORAb-009 amatuximab mesothelin mAb Oncology mesotheliomaEisai P2 Active E7499 E7016 (?) PARP sm Oncology solid tumor and hematological malignancyEisai P2 Active E6005 PDE-4 sm Atopic dermatitisEisai P2 Active E7016 poly(ADP0ribose)polymerase sm Oncology melanomaEisai P3 Active AS-3201 ranirestat aldose reductase sm CNS diabetic neuropathyEisai P3 Active E2007 perampanel Fycompa AMPA receptor sm CNS seizuresEisai P3 Active MORAb-003 farletuzumab Morphotek FOLR1 (folate receptor alpha) mAb Oncology platinum-sensitive ovarian cancer, NSCLCEisai P3 Active E7389 eribulin Halaven microtubule sm Oncology breast,NSCLCEisai P3 Active E5501 AKR-501 avatrombopag thrombopoietin receptor sm CVS thrombocytopeniaEisai P3 Active E5564 eritoran TLR4 sm Inflammation sepsisEisai P3 Active E7080 lenvatinib VEGFR tyrosine kinase sm Oncology thyroid, HCC, endometrial, melanomaElab P2 Active ELND005 Abeta mAb CNS AD

Eli Lilly Market Active gemcitabine Gemzar DNA synthesis sm Oncology pancreatic cacner, lung cancerEli Lilly Market Active cetuximab Erbitux Merck Serono EGFR mAb Oncology CRC, head and neck cancerEli Lilly Market Active abciximab ReoPro Gp IIb/IIIa mAb CVSEli Lilly Market Active duloxetine Cymbalta serotonin-norepinephrine reuptake sm CNS major dipressive disorder, generalized anxiety disorderEli Lilly Market Active pemetrexed Alimta TS, DHRF, GARFT sm Oncology malignant pleural mesothelioma and NSCLCEli Lilly Market Active LY2189265 dulaglutide Trulicity GLP-1 peptide DiabetesEli Lilly P1 Active CSF-1R mAb OncologyEli Lilly P1 Active Ferroportin mAb Nephrology anemiaEli Lilly P1 Active Gemcitabine prodrug NCE Oncology

Eli Lilly P1 Active Hepcidin mAb Nephrology treatment of anemiaEli Lilly P1 Active TYRP1 protein flanvotumab human glycoprotein gp75 mAb Oncology melanomaEli Lilly P1 Active IL-1 beta mAb CVSEli Lilly P1 Active pomaglumetad methionil metabotropic glutamate 2/3 receptors ?Eli Lilly P1 Active LY3023703 mPGES 1 sm AIID inflammation and painEli Lilly P1 Active Notch NCE OncologyEli Lilly P1 Active p38 MAP kinase sm OncologyEli Lilly P1 Active p70 S6 kinase/AKT sm OncologyEli Lilly P1 Active PI3K + mTOR kinase NCE OncologyEli Lilly P1 Active RON mAb OncologyEli Lilly P1 Active VEGFR3 mAb OncologyEli Lilly P1 Active biologics CVSEli Lilly P1 Active biologics DiabetesEli Lilly P1 Active biologics DiabetesEli Lilly P1 Active biologics DiabetesEli Lilly P1 Active biologics OncologyEli Lilly P1 Active NCE CNS bipolarEli Lilly P1 Active NCE CNS cognitive impairment in schizophreniaEli Lilly P1 Active NCE DiabetesEli Lilly P1 Active NCE DiabetesEli Lilly P1 Active NCE OA OAEli Lilly P1 Active sm Nephrology CKDEli Lilly P2 Active LY2523199 11 beta HSD 1 (hydroxysteroid deh sm Diabetes T2DMEli Lilly P2 Active LY2623091 aldosterone receptor sm Nephrology chronic kidney disease associated with diabetesEli Lilly P2 Active LY2157299 ALK5 sm Oncology Glioma, HCC, pancreatic cancerEli Lilly P2 Active LY2886721 beta secretase sm CNS ADEli Lilly P2 Active LY3012207 olaratumab CD-140a(PDGFR alpha) mAb Oncology NSCLC, glioblastomaEli Lilly P2 Active LY2835219 CDK4/6 sm OncologyEli Lilly P2 Active LY2951742 Arteaus CGRP=calcitonin gene-related peptimAb CNS prophylaxis of migraineEli Lilly P2 Active LY2603618 checkpoint kinase (Chk1)1 sm Oncology panreatic cancer, NSCLCEli Lilly P2 Active LY2606368 checkpoint kinase (Chk1)1 sm Oncology cancerEli Lilly P2 Active LY2875358 cMet mAb OncologyEli Lilly P2 Active LY2801653 cMet sm OncologyEli Lilly P2 Active LY2510924 CXCR4 peptide Oncology cancerEli Lilly P2 Active LY2812176 DKK-1 mAb OncologyEli Lilly P2 Active LY2874455 FGF receptor tyrosine kinase sm Oncology cancerEli Lilly P2 Active LY2409021 glucagon receptor sm Diabetes T2DMEli Lilly P2 Active LY2090314 GSK3beta sm Oncology cancerEli Lilly P2 Active LY3012217 cixutumumab IGF-1R mAb Oncology NSCLCEli Lilly P2 Active LY2784544 JAK2 sm Oncology myeloproliferative neoplasmEli Lilly P2 Active LY2523355 litronesib mitotic kinesin Eg5 sm Oncology cancerEli Lilly P2 Active LY2495655 Myostatin mAb Oncology disuse muscle atrophy, cancer cachexiaEli Lilly P2 Active LY2940094 n/a sm CNS depression

Eli Lilly P2 Active LY3016859 n/a Nephrology CKDEli Lilly P2 Active LY2541546 blosozumab sclerostin mAb osteoporosisEli Lilly P2 Active LY2940680 SMO(Smoothened) sm Oncology cancerEli Lilly P2 Active LY2382770 TGF beta mAb CNS diabetic neuropathyEli Lilly P2 Active LY3012212 icrucumab VEGFR1 mAb Oncology bladder cancerEli Lilly P3 Active LY2062430 solanezumab Abeta mAb CNS ADEli Lilly P3 Active LY2127399 Tabalumab BAFF (B-cell activating factor) mAb AIID, Oncology lupus, MMEli Lilly P3 Active LY2484595 Evacetrapib CETP sm CVSEli Lilly P3 Active LY3012211 IMC-11F8 necitumumab EFGR mAb Oncology Sq NSCLCEli Lilly P3 Active LY2439821 Ixekizumab IL-17A mAb AIID psoriasis, psoriatic arthritisEli Lilly P3 Active LY2605541 basal insulin analog insulin biologics Diabetes T2DMEli Lilly P3 Active LY2963016 new insulin glargine product Insulin biologics DiabetesEli Lilly P3 Active LY3009104 baricitinib JAK1/2 sm AIID RA, psoriasis,diabetic nephropathyEli Lilly P3 Active LY317615 enzastaurin PKC beta, AKT sm Oncology diffuse large B-cell lymphomaEli Lilly P3 Active LY2216684 edivoxetine reputake of norepinephrine sm CNS depressionEli Lilly P3 Active LY3009806 IMC-1121B ramucirumab VEGFR-2 mAb Oncology 2nd line gastric cancerEli Lilly Reg Active LY3031642 liprotamase liprotamase Enzyme repla Metabolic disor Enzyme replacementEli Lilly Registration Active BI10773 empagliflozin BI SGLT2 sm Diabetes T2DM

Emergent BioSolution P2 Active zanolimumab CD-4 mAb Oncology perpheral T-cell lymphomaEndo Pharma Market Active valrubicin Valstar antimetabolite sm Oncology bladder cancer

Endocyte P3 Active EC145 vintafolide FOLR1 (folate receptor alpha) LDC Oncology ovarian, NSCLC, breast cancerEndocyte PC Active EC0371 FOLR1 (folate receptor alpha) LDC AIIDEndocyte PC Active EC1719 PSMA LDC Oncology prostate cancer

EnVivo P2 Active EVP-0962 gamma secretase sm CNS ADEnVivo P2 Active EVP-6124 nicotine A7 sm CNS ADEnzon P1 Active EZN-2968 HIF 1 alpha sm Oncology solid tumors

Epizyme P1 Active EPZ-5676 Celgene HMT(DOT1L) sm Oncology acute leukemia with MLL gene rearrangementEpizyme P2 Active EPZ-6438 E7438 HMT(EZH2) sm Oncology NHL with oncogenic EZH2 mutationsEsperion P2 Active ETC-1002 ATP citrate lyase (ACL) sm CVS hypercholesterolemia

EUSA PHARMA USA Market Active asparaginase ErwinErwinaze Oncology acute lymphoblastic leukemiaEvec, Inc PC Active Anti-HMGB1 HMGB-1 mAb CNS neuropathic painExelixis Market Active XL-184 cabozantinib Cometriq RET, Met sm Oncology metastatic medullary thyroid cancerExelixis P3 Active XL518 GDC-0973 cobimetinib MEK1/2 sm OncologyExelixis PC Active XL499 MERCK PI3K delta sm AIIDExelixis PC Active BMS ROR sm AIIDExelixis PC Active XL475 BMS TGF5 sm Diabetes T2DMFabrus PC Active PSMA mAb OncologyFabrus PC Active Tim-3 mAb AIIDFerring Market Active FE200486 degarelix Firmagon gonadotropin-releasing hormone resm Oncology prostate cancer

FibroGen P2 Active FG-3019 CTGF mAb Oncology panreatic cancer, IPFFive Prime P1 Active FPA008 CSF1F mAb OncologyFivePrime P1 Active FP-1039 GSK3052230 FGFs mAb OncologyFivePrime PC Active FPA144 FGF receptor 2b mAb Oncology gastric cancer

Flexion P2 Active FX005 p38 MAPK sm OAFOB Synthesis PC Active FSI-1671/86 AstraZeneca carbapenem sm Infection

Fondazione Instituto ItalianoDis Active FAAH (fatty acid amide hydrolase) sm CNS painForest Market Active roflumilast PDE-4 sm Respiratory COPDForest P2 Active GKI-399 Glucokinase sm Diabetes T2DMForest P2 Active GRT6005 ORL-1 and mu opioid receptor CNS painForest P2 Active cebranopaldo sm OA pain

Fresenius ? Active catumaxomab Trion CD-3 + EpCAM bispecific mAbOncology gastric cancer and ovarian cancerFuriex P3 Active eluxadoline opiod receptor sm Irritable bowel disease

Galapagos P2 Active GLPG0974 GSK2586184 GSK FFA2 sm AIID UC, psoriasisGalectin Therapeutics P1 Active GR-MD-02 Galectin sm Fibrosis fatty liver disease, lung fibrosis, kidney fibrosisGalectin Therapeutics P1 Active GM-CT-01 Galectin sm Oncology melanomaGalectin Therapeutics P1 Active GM-MD-02 Galectin sm Oncology melanoma

Ganymed PC Active IMAB362 Claudin-18.2 (CLDN18.2) mAb Oncology solid tumorGanymed PC Active IMAB027 GT512 mAb Oncology solid tumor

Gedeon Richter P2 Active RGH-478 Bradykinin B1 receptor sm CNS painGene Signal P2 Active GS-101 aganirsen IRS-1 NAT Dermatology Psoriasis

Generics Market Active colchicine Colcrys tubulin sm goutGenerics Market Active prednisone Rayos sm AIID Inflammatory disease, COPD etcGenerics Market Active allopurinol Xanthine oxidase sm goutGenmab PC Active HuMax-CD74 CD-74 ADC Oncology solid and hematological tumorsGenmab PC Active HuMax-TF ADC Tissue factor ADC OncologyGenzyme Market Active alemtuzumab Campath CD-52 mAb Oncology CLLGenzyme Market Active hyaluronic acid Synvisc polymer OA

Geron P2 Active imetalstat telomerase NAT OncologyGilead Market Active oseltamivir Tamiflu neuraminidase sm Infection InfluenzaGilead Market Active ambrisentan Letairis/Volibris Myogen, GSK type A endothelin receptor (ETA) sm CVS Pulmonary artery hypertensionGilead P1 Active GS-5745 MMP9 mAb AIID UCGilead P1 Active GS-5745 MMP9 mAb Oncology solid tumorGilead P1 Active GS-4774 tarmogen T cellGilead P1 Active GS-9620 TLR-7 sm HBV, HCVGilead P1 Active GS-6615 CVS Ischemic Heart Disease and ArrhythmiasGilead P2 Active momelotinib JAK sm Oncology MyelofibrosisGilead P2 Active GS-6624 AB0024 simtuzumab LOXL2 mAb metabolic disordliver fibrosis due to NASHGilead P2 Active GS-6624 AB0024 simtuzumab LOXL2 mAb Oncology myelofibrosis, pancreatic cancerGilead P2 Active GS-9451 NS3 protease sm HCVGilead P2 Active GS-5816 NS5A sm HCVGilead P2 Active GS-9669 NS5B sm HCVGilead P2 Active GS-9820 PI3K delta sm Oncology hematological malignancyGilead P2 Active CAL101 PI3K delta sm Oncology leukemiaGilead P2 Active GS-9973 SYK sm Oncology hematological malignancyGilead P2 Active ranolazine/dronedarone sm CVS Paroxysmal Atrial FibrillationGilead P2 Active GS-5806 sm Infection RSV

Gilead P3 Active ranolazine Nav1.7, Nav1.8, Nav1.5, calcium ch sm CVS incomplete vascularization post PCI, neuropathic painGilead P3 Active ranolazine Nav1.7, Nav1.8, Nav1.5, calcium ch sm Diabetes T2DMGilead P3 Active idelalisib PI3K delta sm Oncology CLL, NHLGilead P3 Active GS-9268 aztreonam lysine sm Infection Non-CF BronchiectasisGilead PC Active GDC-0834 Genentech Btk sm Oncology hematological malignanciesGilead Reg Active PSI-7977 GS-7977 sofosburvir NS5B sm Infection HCV

Glenmark P1 Active GBR 900 TrkA mAb CNS painGlenmark P2 Active GRC 17536 TRPA 1 sm CNS Pain, respiratory dieaseGlenmark PC Active GBR 830 OX40 mAb AIIDGlenmark ActiveGlenmark Active

Gliknik PC Active GL-2045 Fc receptor fusion protein AIID IVIGGlycoMimetics P2 Active GMI-1070 Pfizer E-,L-, P-selectin sm CVS vaso-occlusive crisis of sickle cell diseaseGlycoMimetics PC Active CXCR4 and E-selectin sm Oncology blood cancerGlycoMimetics PC Active GMI-1271 E-selectin sm Oncology blood cancerGlycoMimetics PC Active GMI-1051 Pseudomonas. Aeruginosa sm Infection P. aeruginosa

GNT PC Active AAD-204OAc mPGES 1 sm AIID inflammation and painGSK P1 Terminated GSK1059615 PI3K sm OncologyGSK P3 Inactive vercirnon CCR9 sm AIID Crohn's diseaseGSK Dis Active PERK sm CNS AD, PD GSK Dis Active RIP2 sm AIIDGSK Market Active ondansetron Zofran 5-HT3 sm Oncology chemo-/radiation-induced nauseaGSK Market Active raxibacumab anthrax mAb Infection anthraxGSK Market Active Belimumab Benlysta B-cell activating factor mAb AIID Systemic lupus erythematosusGSK Market Active dabrafenib Tafinlar BRAF sm Oncology Melanoma, NSCLCGSK Market Active ofatumumab Arzerra Genmab CD-20 mAb Oncology CLLGSK Market Active Tositumomab Bexxar Corixa CD-20 mAb Oncology CD20 positive follicular NHLGSK Market Active nelarabine Arranon DNA synthesis sm Oncology T-cell acute lymphoblastic leukemiaGSK Market Active Lapatinib Tykerb EGFR and ErgB2 sm Oncology Breast cancerGSK Market Active Cervarix HPV vaccine Infection HPVGSK Market Active GSK1120212 trametinib Mekinist MEK1/2 sm Oncology Kras-mutant NSCLC, melanomaGSK Market Active topotecan Hycamtin topoisomerase sm Oncology mOvarian cancer, SCLCGSK Market Active pazopanib Votrient VEGFR1/2/3 TK, PDGFG etc sm Oncology RCC, sarcomaGSK Market Active MenHibrix vaccine Infection Hib-MenCY-TTGSK Market Active Nimenrix vaccine Infection MenACWY-TTGSK Market Active vaccine Infection seasonal influenzaGSK P1 Active GSK2110183 AKT sm Oncology MMGSK P1 Active GSK2849466 androgen receptor sm CVS heart failureGSK P1 Active GSK525762 IBET-762 bromodomain sm Oncology NUT gene midline carcinomaGSK P1 Active otelixizumab CD-3 mAb AIID RAGSK P1 Active GSK1325756 CXCR2 sm Respiratory COPDGSK P1 Active OMP-21M18 demcizumab DLL-4 mAb Oncology solid tumorGSK P1 Active GSK2890457 endogenous gut peptide stimulatorpeptide metabolic disordobesity

ChemoCentryx

GSK P1 Active GSK3052230 FP-1039 Five Prime TherapeFGF biologics Oncology cancerGSK P1 Active GSK2256098 focal adhesion kinase sm Oncology cancerGSK P1 Active GSK2374697 GLP-1 mAb metabolic disordobesityGSK P1 Active GSK2647544 Lp-PLA2 sm CNS ADGSK P1 Active trametinib+2141795 MEK1/2+AKT sm Oncology cancerGSK P1 Active GSK356278 PDE-4 sm CNS Huntington's diseaseGSK P1 Active GSK2269557 Phosphoinositide 3 kinase sm Respiratory asthma, COPDGSK P1 Active GSK2636771 PI3K sm Oncology cancerGSK P1 Active PRAME biologics Oncology NSCLCGSK P1 Active GSK1614235+2330672 SGLT1 + ileal bile acid transport(iBAsm Diabetes T2DMGSK P1 Active GSK2339345 sodium channel sm Respiratory coughGSK P1 Active GSK2256294 soluble epoxide hydrolase sm Respiratory COPDGSK P1 Active GSK1995057 TNFR-1 (tumor necrosis factor recepmAb acute lung injuryGSK P1 Active GSK2140944 topo 2 sm Infection bacterial infectionGSK P1 Active WT1 biologics Oncology breast cancerGSK P1 Active GSK2661380 biologics Oncology solid tumorGSK P1 Active GSK685698 fluticasone furoate+vilanterol+umedidinum sm Respiratory COPDGSK P1 Active vaccine Infection HIVGSK P1 Active vaccine Infection non-typeable Hib GSK P1 Active vaccine Infection S. aureusGSK P2 Active GW 869682 SGLT2 sm Diabetes T2DMGSK P2 Active GSK2190915 5 lipoxygenase-activating protein(F sm Respiratory asthmaGSK P2 Active GSK742457 5-HT6 receptor sm CNS dementiaGSK P2 Active GSK742457 5-HT6 receptor sm CNS ADGSK P2 Active GSK933776 Abeta mAb Opthalmology geographic retinal atrophyGSK P2 Active GSK2110183 AKT sm Oncology Langerhan cell histiocytosis, ovarian cancerGSK P2 Active GSK2251052 AN3365 Anacor aminoacyl-tRAN synthetase Infection antibacterialGSK P2 Active GSK2586881 angiotensin converting enzyme 2 acute lung injuryGSK P2 Active belimumab B lymphocyte stimulator mAb Nephrology idiopathic membranous nephropathyGSK P2 Active ronacaleret calcium receptor sm allogeneic hematopoietic stem cell mobilisationGSK P2 Active GSK2941266 CCR1 sm AIID RAGSK P2 Active ofatumumab Arzerra Genmab CD-20 mAb AIID MSGSK P2 Active GSK1363089 XL880 foretinib cMet sm Oncology CancerGSK P2 Active firategrast dula alpha 4 integrin sm AIID MSGSK P2 Active GSK239512 H3 receptor sm AIID MSGSK P2 Active GSK1278863 HIF PH sm Nephrology anemiaGSK P2 Active GSK1070806 IL-18 mAb Diabetes T2DMGSK P2 Active GSK1265744 integrase sm Infection HIVGSK P2 Active Galaphagos JAK1 sm AIID Lupus, psoriasisGSK P2 Active rilapladib Lp-PLA2 sm CNS ADGSK P2 Active tafenoquine malaria sm Infection Plasmodium vivax malariaGSK P2 Active GSK962040 camicinal motilin reeptor sm metabolic disorddelayed gastric emptyingGSK P2 Active GSK249320 myelin-associated glycoprotein mAb stroke

GSK P2 Active GSK1223249 ozanezumab NOGO-A mAb amyotrophic lateral sclerosisGSK P2 Active retosiban oxytocin sm threatened pre-term labourGSK P2 Active GSK2140944 losmapimod p38 MAP kinase sm Respiratory COPDGSK P2 Active p38 MAP kinase sm Respiratory acute lung injuryGSK P2 Active GSK1322322 polypeptide deformylase sm Infection bacterial infectionGSK P2 Active eltrombopag Revolade/Promacta throbopoietin rceptor sm Oncology acute myeloid leukemia, aplastic anemia, myelodysplastic syndromesGSK P2 Active GSK2245035 TLR-7 sm Respiratory asthmaGSK P2 Active mapatumumab TRAIL-R1 mAb Oncology advanced hepatocellular carcinomaGSK P2 Active GSK2336805 sm Infection HCVGSK P2 Active fluticasone furoate+umeclidinium sm Respiratory asthmaGSK P2 Active GSK961081 sm Respiratory COPDGSK P2 Active vaccine Infection streptococcus pneumoniae diseaseGSK P2 Active vaccine Infection HIVGSK P2 Active vaccine Infection tuberculosisGSK P2/3 Active GSK2696266 cephalosporin Infection bacterial infectionGSK P3 Active MAGE-A3 biologics Oncology melanma, NSCLCGSK P3 Active belimumab Benlysta B lymphocyte stimulator mAb AIID Systemic lupus erythematosusGSK P3 Active vilanterol beta2 sm Respiratory COPDGSK P3 Active ofatumumab Arzerra Genmab CD-20 mAb Oncology CLL, diffuse large B cell lymphoma, follicular lymphomaGSK P3 Active GSK2402968 drisapersen dystrophin NAT Rare disease Duchenne musclular dystrophyGSK P3 Active GSK685698 fluticasone furoate glucocorticoid sm Respiratory asthmaGSK P3 Active lapatinib Tykerb HER2+EGFR sm Oncology breast cancer, gastric, head&neckGSK P3 Active mepolizumab IL-5 mAb Respiratory severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA)GSK P3 Active sirukumab IL-6 mAb AIID RAGSK P3 Active dolutegravir+abacavir sulphate+lamivudine integrase + reverse transcriptase sm Infection HIVGSK P3 Active vilanterol long-acting beta2 agonist Respiratory COPDGSK P3 Active darapladib Lp-PLA2 sm CVS artherosclerosisGSK P3 Active pazopanib Votrient multi-kinase sm Oncology ovarian cancer,RCCGSK P3 Active zanamivir Relenza neuraminidase sm Infection influenzaGSK P3 Active GSK2696273 biologics Rare disease adenosine deaminase severe combined immune dificiency(ADA-SCID)GSK P3 Active IPX066 Patrome sm CNS PDGSK P3 Active losquirix vaccine Infection malariaGSK P3 Active vaccine Infection MMRGSK P3 Active vaccine Infection Herpes Zoster GSK P3 Active GSK573719 umeclidinium Respiratory COPDGSK P3 Active vilanterol+fluticas Relvar/Breo Respiratory COPDGSK Reg Active albiglutide GLP-1 peptide Diabetes T2DMGSK Reg Active dolutegravir integrase sm Infection HIVGSK Reg Active vaccine Infection influenzaGSK Reg Active vilanterol+fluticas Relvar/Breo Respiratory asthmaGSK Reg Active trametinib Mekinist MEK sm Oncology metastatic melanomaGSK Terminated Active Agenus MAGE-A3 biologics Oncology melanoma, NSCLC

Hanmi Dis Active GPR119 sm Diabetes ƒ

Hanmi P1 Active HM71224 Btk sm AIID RAHanmi P1 Active HM61713 EGFR mutant selective sm Oncology NSCLCHanmi P2 Active HM61713 EGFR TK (pan-HER) sm Oncology GastricHanmi PC Active HM95573 BRAF and N-RAS sm Oncology

Heidelberg Dis Active amanitin Roche RNA polymerase II ADCHelsinn Market Active palonosetron Aloxi 5-HT3 sm Oncology prevention of nausea and vomiting (CINV)

High Point P1 Active HPP 854 beta secretase sm CNS ADHua Medicine P1 Active HMS5552 Roche Glucokinase sm Diabetes T2DM

HutchisonMed PharmaP1 Active HMPL-813 epitinib EGFR sm OncologyHutchisonMed PharmaP1 Active HMPL-013 fruquintinib Eli Lilly VEGFR-1,2,3 sm OncologyHutchisonMed PharmaP1 Active HMPL-012 sulfatinib VEGRFs, FGFR-1 sm OncologyHutchisonMed PharmaP3 Active HMPC-004 botanical extract sm AIIDHutchisonMed PharmaPC Active HMPL-309 EGFR sm Oncology

Ignyta Dis Active Spark-1,2,3, sm Oncology

Ignyta P1 Active RXDX-101 Trk, ROS1, ALK sm Oncology

Ignyta PC Active RXDX-102 Trk sm OncologyImmune P2 Active CAT-213 iCo-008 bertilimumab CAT Eotaxin-1 mAb AIID IBD

Immunocore P2 Active IMCgp100 gp100 biologics Oncology melanomaImmunoGen P1 Active IMGN alpha v integrin ADC Oncology solid tumorsImmunoGen P1 Active IMGN289 EGFR ADC OncologyImmunoGen P2 Active IMGN901 BB-10901 Lorvotuzumab mertansine CD-56 ADC Oncology MMImmunoGen P2 Active IMGN853 FOLR1 (folate receptor alpha) ADC Oncology ovarian cancer, solid tumorImmunoGen PC Active IMGN529 CD-37 ADC Oncology B-cell lymphoma, NHL

ImmunOligo GmbH PC Active ImOI100 RIG-1 NAT Oncology ovarian anc prostateImmunomedics P1 Active IMMU-130 labetuzumab-SN-38 CD-66e(=CEA) ADC Oncology CRCImmunomedics P1 Active milatuzumab-Dox CD-74 ADC Oncology MMImmunomedics P1 Active IMMU-115 milatuzumab CD-74 mAb Oncology CLLImmunomedics P1 Active CEACAM5 ADC OncologyImmunomedics P1 Active IMMU-132 TROP-2(=TACSTD2) ADC OncologyImmunomedics P2 Active IMMU-106 veltuzumab CD-20 mAb AIID immune thromobocytopenic purpura, RAImmunomedics P2 Active IMMU-106 veltuzumab CD-20 mAb Oncology CLLImmunomedics P2 Active IMMU-102 epratuzumab Y-90 CD-22 mAb Oncology NHLImmunomedics P2 Active epratuzumab/veltuzumab CD-22 mAb Oncology NHLImmunomedics P2 Active clivatuzumab MUC1 human mucin mAb Oncology pancreatic cancerImmunomedics P3 Active epratuzumab CD-22 mAb AIID SLE

Incyte Market Active ruxolitinib Jakafi/jakavi JAK1/JAK2 sm Oncology myelofibrosis, pancreatic cancerIncyte P2 Active INCB39110 JAK1 sm AIID RAInDex P3 Active kappaproct TLR9 NAT AIID UC(ulcerative colitis)

Infinity P2 Active IPI-504 retaspimycin HCl hsp90 sm Oncology NSCLCInfinity P2 Active IPI-145 PI3K delta and gamma sm Oncology indolent NHL, RAInfinity P2 Active IPI-926 saridegib SMO(Smoothened) sm Oncology pancreatic cancerInfinity PC Active IPI-443 PI3K delta and gamma sm OncologyInnate Dis Active NKp46 mAb AIID

hPAM4-Cide

Innate Dis Active IPH33 TLR3 mAb AIID COPD, RAInnate PC Active IPH41 KIR3DL2 mAb Oncology cutaneous T-cell lymphoma

Intellikine P1 Active INK1117 PI3K alpha sm Oncologyintercept P3 Active OCA obeticholic acid FXR (farnesoid X receptor) sm metabolic disordNASH (non-alcoholic steatohepatitis)

InterMune P3 Active pirfenidone Shionogi TGF betastimulated collagen produtsm Respiratory Idiopathic pulmonary fibrosisiPierian PC Active PIN007 BMS tau (extrcellular tau) mAb CNS Tauopathy (AD etc)

ISIS Dis Active ISIS-DGAT2rx DGAT2 NAT DiabetesISIS Market Active ApoB-100 Kynamro Genzyme ApoB-100 NAT CVSISIS P1 Active ISIS 388626 SGLT2 sm Diabetes T2DMISIS P1 Active ISIS-APOArx Apo(a) NAT CVSISIS P1 Active ISIS-APOCIIIRx apolipoprottein C-III protein NAT Diabetes T2DMISIS P1 Active C9orf72 NAT CNS ALSISIS P1 Active ISIS-FGFR4rx FGFR NAT DiabetesISIS P1 Active ISIS-GCCRrx GCCR NAT Rare diseaseISIS P1 Active ISIS-PTP1BRx PTP1B NAT Diabetes T2DMISIS P2 Active Plazomicin Achaogen Amonoglycoside NAT AIIDISIS P2 Active iCo-007 iCo C-raf kinase NAT AIIDISIS P2 Active ISIS-CRPRx C-reactive protein NAT AIID RAISIS P2 Active EXE 001 Pfizer CTGF NAT AIIDISIS P2 Active ISIS-E1F4Erx eIF-4E NAT OncologyISIS P2 Active ISIS-FXIrx Factor XI NAT CVSISIS P2 Active ATL1103 ATL GHr NAT Rare diseaseISIS P2 Active OGX-427 OncoGenex hsp27 NAT OncologyISIS P2 Active ISIS-SMNrx Biogen Idec SMN2 NAT Rare diseaseISIS P2 Active ISIS-STAT3rx AstraZeneca STAT3 NAT OncologyISIS P2 Active ATL1102 ATL VLA-4 NAT AIIDISIS P3 Active Custirsen Teva/OncoGenex clusterin NAT OncologyISIS P3 Active Alicaforsen Atlantic ICAM-1 NAT Rare diseaseISIS P3 Active ISIS-TTRrx GSK TTR NAT Rare diseaseISIS PC Active ISIS-ANGPTL3rx ANGPTL3 NAT CVSISIS PC Active ISIS_Arrx AstraZeneca AR NAT OncologyISIS PC Active ISIS-FVIIrx Factor VII NAT CVSISIS PC Active Roche Hungtingtin NAT CVS Huntington's dieaseISIS PC Active ISIS-GSK3rx GSK NAT AIIDJ&J Market Active muromonab Orthoclone OKT3 CD-3 receptor mAb AIID transplant rejectionJ&J Market Active golimumab Simponi TNF-alpha mAb AIID RA, Ankylosing spondylitisJ&J Market Active infliximab Remicade TNF-alpha mAb AIID RA

Janssen Dis Active FLAP sm AIIDJanssen Dis Active GPR81 (=HCA1) sm metabolic disorderJanssen Market Active canagliflozin Ivokana MitsubishiTanabe SGLT2 sm Diabetes T2DMJanssen Market Active abiraterone Zytiga 17 alpha-hydroxylase(CYP17A1) sm Oncology prostate cancerJanssen Market Active doxorubicin Doxil DNA intercalator sm Oncology refractory ovarian cancerJanssen Market Active CNTO-1275 ustekinumab Stelara IL1-2, IL-23 mAb AIID RA, sarcoidosis, moderate to severe plaque psoriasis

Janssen Market Active golimumab Simponi TNF-alpha mAb AIID RAJanssen P1 Active PF-05236812 AAB-003 Abeta mAB CNS ADJanssen P1 Active JNJ-26854165 p53-HDM2 sm Oncology NSCLCJanssen P1 Active CNTO-5825 IL-13 mAb Respiratory allergic asthmaJanssen P1 Active CNTO05 mAb AIID inflammationJanssen P1 Active CNTO-3157 mAb Respiratory asthmaJanssen P1 Active JNJ-39439335 mavatrep sm OAJanssen P2 Active daratumumab Genmab CD-38 mAb Oncology MMJanssen P2 Active CNTO-95 Intetumumab CD-51 (alpha v integrin) mAb Oncology prostate cancerJanssen P2 Active JNJ-38518168 histamin H4 receptor sm AIID RAJanssen P2 Active CNTO-1959 MorphoSys IL-23 mAb AIID RAJanssen P2 Active CNTO-136 sirukumab IL-6 mAb AIID lupus nephritisJanssen P2 Active CNTO-328 siltuximab IL-6 mAb Oncology MM, myelodysplastic syndromeJanssen P2 Active JNJ-40346527 M-CSF receptor sm AIID RAJanssen P2 Active JNJ-40411813 mGluR2 sm CNS depressionJanssen P2 Active carlumab monocyte chemoattractant proteinmAb pulmonary fibrosisJanssen P2 Active fulranumab NGF beta mAb cancer painJanssen P2 Active TLR3 mAb AIIDJanssen P2 Active PF-05236806 ACC-001 CNS ADJanssen P3 Active CNTO-136 sirukumab IL-6 mAb AIID RAJanssen reg Active PCL-32765 ibrutinib Pharmacyclics Btk sm Oncology hematological malignanciesJanssen P2 JNJ-26481585 HDAC (pan-) sm Oncology Lymphoma

Juno Therapeutics P2 Active JCAR015 CD28, CD3 CART Oncology ALLJuno Therapeutics P2 Active JAR014 CD19 CART Oncology CLL, NHLLJuno Therapeutics P2 Active JAR017 CD19 CART Oncology Leukemia

Juventas P2 Active JVS-100 SDF-1 gene therapy CVS critical limb ischemiaKalidex PC Active KPI-10 Fluorquinolone sm Infection Broad spectrum

KaloBios P1 Active KB004 EphA3 mAb Oncology hematological malignanciesKaloBios P2 Active KB003 GM-CSF mAb Respiratory severe asthmaKaloBios P2 Active KB001 Sanofi Pasteur TTSS (Pseudo. Aeruginosa) mAb Infection P.aeurginosa infection

Karyopharm P1 Active KPT-330 selinexor exportin 1 sm Oncology solid tumorKDDF Dis Active SKAI Clec14a mAb OncologyKDDF Dis Active Donga socio DS-20 sm Oncology triple negative breast cancerKDDF Dis Active Jung-Ang Univ EGFR mAb OncologyKDDF Dis Active Kangwong Univ L1CAM mAb OncologyKDDF Dis Active SKAI miRNA-206 NAT CNS ADKDDF Dis Active UCP sm OncologyKDDF Dis Active SNU mAb CNSKDDF Dis Active Hallym Univ sm CNS CINPKDDF Dis Active KIST sm CNS dipressionKDDF P2 Active YKP3089 SK Biopharm UCP sm CNS DepressionKDDF PC Active MD3 ICAM-1 mAb AIID tramsplantation rejectionKissei P2 Active KGT-1681 remogliflozin GSK discontinued SGLT2 sm Diabetes T2DM

KRICT Dis Active Ack1 sm OncologyKRICT Dis Active DRB1 sm OncologyKRICT Dis Active EGFR double mutant sm OncologyKRICT Dis Active GPR119 sm Diabetes T2DMKRICT Dis Active NFAT5 sm AIIDKRICT Dis Active PI3K sm AIIDKRICT Dis Active SIRT7 sm OncologyKRICT Dis Active Urotensin sm CVS acute myocardial infarctionKRICT PC Active ALK/Ack1 sm Oncology NSCLCKRICT PC Active cMet sm Oncology gastric cancerKudos PC Active KU-60019 ATM sm Oncology

KULeuven Dis TRPM3 sm CNS pain (neuropathic pain)Kyorin P2 Active KRP-Am1977Y DNA gyrase sm Infection quinolone

KyowaHakko Kirin P3 Active mogamulizimab CCR4 mAb Oncology cutaneous T-cell lymphomaLanthio Pharma Dis Active gastrin-releasing peptides(GRP) recpeptide Oncology prostate cancerLanthio Pharma PC Active LP2-3 angiotensin II type 2 (AT2) receptorsm Respiratory pulmonary fibrosisLbrys Biologics P2 Active RN-307 Rinat/Pfizer calcitonin gene related peptide mAb CNS migraine

Legochem Dis Active Sanofi autotaxin sm Oncology CancerLexicon P2 Active LX2931 S1P lyase sm AIID RALexicon P2 Active LX4211 SGLT2 sm Diabetes T2DMLexigen P1 Active EMD 273 066 huKS-IL2 Merck Serono EpCAM biologics

LG Life Sciences Market Active gemigliptin Gemiglo DPP-4 sm Diabetes T2DMLife Science P2 Active KW-2871 ecromeximab GD3 (ganglioside) mAb Oncology melanoma

Lixte P1 Active LB-201/205 HDAC sm CNS misfolded proteins (Gaucher, neurofibromotosis 2 etc)Lixte P1 Active LB-100 Protein phosphatase 2A(PP2A) sm OncologyLpath P1 Active sonepcizumab sphingosine 1 phospate mAb Oncology solid tumorsLpath PC Active Lpathomab LPA(lysophosphatidic acid) mAb CNS dibetic peripheral neuropathy, diabetic neuropahic pain

Lundbeck P2 Active Lu AE58054 5-HT6 receptor antagonist sm CNS ADMacroGenics P1 Active MAG271 Servier B7-H3 mAb OncologyMacroGenics P3 Active teplizumab Eli Lilly CD-3 mAb Diabetes T1DM

Mapp P2 Active Zmapp Ebola virus mAb Infection Ebola virus infectionMedarex Active MDX-1414 glypican-3 mAb Oncology HCC

MedImmune P1 Active MEDI-547 EhpA2 ADC Oncology solid tumorsMedivir P1 Active MIV-711 Cathepsin K sm osteoporosisMedKoo P1 Active Palomid 529 PI3K sm Oncology

MedPacto P1 Active TEW-7197 EW-7197 Ihwa Woman's UnALK5 sm Oncology solid tumorsMelinta P2 Active RX-01 radezolid sm Infection CABP pathogens and mycobacterium sp.Melinta P3 Active delafloxacin DNA gyrase sm Infection uncomplicated honorrhea, ABSSS infectionMelinta PC Active RX-04 pyrrolocytosines sm infection ESKAPEMelinta PC Active RX-02 macrolides sm infectionMerck Terminated Inactive SCH 530348 vorapaxar thrombin receptor (PAR-1) sm CVS acute coronary syndromeMerck Market Active sitagliptin Januvia DPP-4 sm Diabetes T2DMMerck Market Active temozolomide Temodar alkylating agent sm Oncology refractory anaplastic astrocytoma

Merck Market Active valdecoxib Bextra COX-2 sm OA, RAMerck Market Active rofecoxib Vioxx COX-2 smMerck Market Active Gardisil HPV vaccine InfectionMerck Market Active aprepitant Emend neurokinin 1 receptor sm Oncology nausea and vomiting associated with chemoMerck Market Active MK-0653C ezetimibe/atorvastliptruzet CVS atherosclerosisMerck Market Active type 6, 11, 16, 18 Gardisil vaccine Oncology cervical cancer Merck Market Active peginterferon alphSylatron protein Oncology melanomaMerck Market Active MK-3475 pembrolizumab Keytruda PD-1 mAb Oncology melanomaMerck P1 Active MK-8808 sm AIID RAMerck P2 Active MK-7655 beta lactamase sm Infection bacterial infectionMerck P2 Active MK-3102 DPP-4 sm Diabetes T2DMMerck P2 Active MK-0646 dalotuzumab Insulin-like growth factor 1 receptomAb Oncology Neuroendocrine tumorMerck P2 Active MK-8669 AP23573 ridaforolimus Ariad. Merck returmTOR sm Oncology cancerMerck P2 Active MK-5172 NS3/4a protease Infection HCVMerck P2 Active MK-8742 NS5A Infection HCVMerck P2 Active MK-4827 niraparib Tesaro PARP sm OncologyMerck P2 Active V114 Pneumococcal vaccine Infection PneumococcusMerck P2 Active MK-8237 AIID allergyMerck P2 Active MK-1602 CNS migraineMerck P2 Active MK-6096 CNS insomniaMerck P2 Active MK-8228 letermovir Infection CMVMerck P2 Active MMK-1439 Infection HIVMerck P2 Active V114 Infection PneumococcusMerck P2 Active MK-2206 OncologyMerck P2 Active MK-1029 Respiratory asthma, COPDMerck P2 Active MK-4618 overactive bladderMerck P2 Active MK-8175A Contraception, next generation ringMerck P2 Active MK-8342 Contraception, medicated IUSMerck P2 Active MK-8342B Contraception, next generation ringMerck P3 Active MK-3814 preladenant Schering-Plough adenosine A2A receptor sm CNS PDMerck P3 Active MK-8931 BACE sm CNS ADMerck P3 Active MK-0822 odanacatib cathepsin K sm osteoporosisMerck P3 Active MK-7965 SCH 727965 dinaciclib CDK Oncology CLL, MM, Breast cancerMerck P3 Active MK-0859 anacetrapib CETP sm CVS atherosclerosisMerck P3 Active MK-8109 vintafolide Endocyte FOLR1 (folate receptor alpha) sm Oncology platinum-resistant ovarian cancerMerck P3 Active MK-7009 vaniprevir NS3/4a sm Infection HCVMerck P3 Active MK-5348 SCH 530348 vorapaxar PAR-1 sm CVS thorombosisMerck P3 Active MK-3415A actoxumab/bezlotoxumab Medarex mAb Infection Clostridium difficileMerck P3 Active V212 vaccine Infection Herpes Zoster Merck P3 Active V503 vaccine Oncology HPV-related cancer Merck P3 Active MK-3641 ALK-Abello A/S AIID allergy, ragweedMerck P3 Active MK-8962 corifollitropin alpha FertilityMerck P3 Active MK-8175A Nomac E2 contraception

Merck P3 Active MK-1293 Samsung Bioepis Insulin receptor biologics Diabetes T2DMMerck Reg Active MK-5592 posaconazole Noxafil Schering-Plough lanosterol 14 alpha demethylase sm Infection antifungalMerck Reg Active MK-4305 suvorexant orexin receptor sm CNS insomniaMerck Reg Active MK-0887A mometasone/formoDulera sm Respiratory COPDMerck Reg Active MK-8616 ORG 25969 sugammadex Bridion Organon/Schering-Plough sm neuromuscular blockade reversal, first selective relaxant binding agentMerck Reg Active MK-7243 AIID allerty, grass pollen

Merck Serono P1 Active ataclcept APRIL & BlyS biologics AIIDMerck Serono P1 Active ATX-MS-1467 Autotaxin peptide AIID MSMerck Serono P1 Active cMet sm Oncology solid tumorMerck Serono P1 Active NHS-IL 12 IL-12 biologics Oncology solid tumorMerck Serono P1 Active MEK 1/2 sm Oncology solid tumorMerck Serono P1 Active SAR245409 Sanofi MEK 1/2 + PI3K sm Oncology solid tumorMerck Serono P1 Active PI-2301 plovamer peptide AIID MSMerck Serono P2 Active ataclcept APRIL & BlyS biologics AIID Systemic lupus erythematosusMerck Serono P2 Active Sym004 EGFR mAb Oncology head and neck cancerMerck Serono P2 Active sprifermin FGF 18 biologics cartilage injuryMerck Serono P2 Active DI17E6 integrin mAb Oncology CRC, prostate cancerMerck Serono P2 Active pimasertib MEK 1/2 sm Oncology pancreatic cancer, melanomaMerck Serono P3 Active cilengitide alpha v integrin sm Oncology GlioblastomaMerck Serono P3 Active TH-302 hypoxia sm Oncology soft tissue sarcoma, pancreatic cancerMerck Serono P3 Active L-BLP25 Stimuvax MUC1 biologics Oncology lung cancerMerck Serono P3 Active sapropterin dihydrKuvan sm Metabolic disor hyperphenylalaninemiaMerck Serono Terminated Active ONO 4641 ceralifimod ONO sphingosine-1-phosphate(S1P) recesm AIID MS

Merrimack P3 Active MM-398 encapsulated irinotecan Baxter sm Oncology Panreatic cancer, CRC, gliomaMethyleGene P1 Active MGCD516 Mirati cMet, VEGF1,2,3, AXL, Tie2 sm Oncology solid tumorMethyleGene P1 Active EVP-0334 HDAC sm CNS HD, PD, ADMethyleGene P2 Active MGCD265 cMet, VEGF1,2,3, AXL, Tie2 sm Oncology solid tumorMethyleGene P2 Active MGCD0103 mocetinostat HDAC sm Oncology solid tumorMethyleGene PC Active MG96077 beta lactamase sm Infection bacterial infectionMethyleGene PC Active MGCD290 Hos2 sm Infection anti-fungalMGI Pharma Market Active pilocarpine Salagen muscarinic acetylcholine receptor sm Dry mouth (Sjogren's syndrome)

MicuRx P1 Active MRX-1 new oxazolidinone antibiotics sm Infection MRSAMirna Dis Active miR-Rxlet-7 let-7 NAT OncologyMirna Dis Active miR-Rx16 miR-16 NAT OncologyMirna Dis Active miR-Rx06 NAT OncologyMirna P1 Active MRX34 miR-34 NAT Oncology HCC and liver related cancerMirna PC Active miR-Rx07 NAT Oncology

MitsubishiTanabe Market Active TA-7284 canagliflozin Ivokana Janssen SGLT2 sm Diabetes T2DMMitsubishiTanabe Market Active teneglipliptin Lenelia DPP-4 sm Diabetes T2DMMitsubishiTanabe P1 Active MP-157 angiotensin II type 2 (AT2) receptorsm CVS hypertensionMitsubishiTanabe P1 Active MT-3995 mineralocorticoid receptor sm CVS hypertensionMitsubishiTanabe P1 Active MP-124 PARP sm CVS acute ischemic strokeMitsubishiTanabe P1 Active MT-1303 S1P receptor sm AIID MS

MitsubishiTanabe P2 Active T-047 firategrast GSK alpha4beta7 integrin sm AIID MSMitsubishiTanabe P2 Active MT-4666 alpha7nACh receptor sm CNS ADMitsubishiTanabe P2 Active TA-7906 Maruho PDE-4 sm Atopic dermatitisMitsubishiTanabe P2 Active Y-39983 Rho kiase sm glaucomaMitsubishiTanabe P3 Active MP-214 cariprazine D3/D2 receptor sm CNS schizophreniaMitsubishiTanabe P3 Active MP-146 Nephrology CKDMitsubishiTanabe reg Active TA-1790 avanafil Vivus PDE-5 sm erectyle dysfunction

Momotaro-Gene Inc P1 Active Ad-REIC REIC/dkk-3 gene therapy OncologyMorphoSys P1 Active MOR208 CD-19 mAb Oncology CLL/SLL, B-ALL & NHLMorphoSys P1 Active XmAb 5574 Xencor CD-19 mAb Oncology CLLMorphoSys P1 Active MOR202 Celgene CD-38 mAb Oncology MMMorphoSys P2 Active MOR103 GSK GM-CSF mAb AIID RA

Naurex P1 Active NRX-1074 NMDA Receptor sm CNS DepressionNaurex P2 Active GLYX-13 ensituximab NMDA Receptor sm CNS Depression, Neuropathic pain

Neogenix P2 Active BPC-1C ensituximab human mucin-5AC mAb Oncology CRC, pancreatic cancerNeomed P2 Active NEO1940 CB1/CB2 agonist sm Oncology supportive careNeomed PC Active NEO5024 NEO5937 P2X3 sm CNS Bladder and OA painNeomed PC Active NEO6860 TRPV1 sm CNS pain

Neurocrine P2 Active NBI-98854 VMTA2 sm tardive dyskinesiaNeurocrine P3 Active elagolix AbbVie gonadotropin-releasing hormone(Rnsm Oncology endometriosis

Nimbus Discovery PC Active ND-630 ACC sm Diabetes T2DM, fatty liver diseasenLife Dis Active 5-HT1A receptor and SERT NAT CNS DepressionnLife PC Active NLF1233 alpha synuclein NAT CNS PD

Nogra P2 Active GED-0301 Celgene Smad7 NAT AIID Crohn's (moderate to severer)Novartis Terminated aliskiren Tekturna renin sm CVS Heart failureNovartis Market Active letrozole Femara aromatase sm Oncology first-line treatment of postmenopausal women with locally avdanced /m breast cancerNovartis Market Active STI-571 imatinib Bcr-Abl tyrosine kinase sm Oncology CML, GISTNovartis Market Active imatinib Gleevec BCR-Abl, Kit, PDGFR TK sm Oncology CML, ALLNovartis Market Active nilotinib Tasigna BRC-Abl, PDGFR TK sm Oncology CMLNovartis Market Active everolimus Afinitor FKBP 12/mTOR sm Oncology RCC etcNovartis Market Active omalizumab Xolair Genetech IgE mAb AIID asthmaNovartis Market Active ACZ885 canakinumab Iiaris IL-1 beta mAb CVS Secondary prevention of cardiovascular events. Systemic juvenile idiopathic arthritisNovartis Market Active basiliximab Simulect IL-2R alpha (CD-25) mAb AIID transplant rejectionNovartis Market Active ruxolitinib Jakavi Incyte JAK 1/2 sm Oncology polycythemia vera, myelofibrosisNovartis Market Active Bexsero Meningococcus vaccine Infection MeningococcusNovartis Market Active afinitor mTOR Oncology DLBCLNovartis Market Active fingolimod Gilenya sm AIID MSNovartis Market Active ranibizumab Lucentis Roche VEGF-A mAb Opthalmology macuar degenerationNovartis Market Active pamidronate Aredia sm Oncology osteolytic bone metastasis of breast cancerNovartis Market Active zoledronic acid Zometa sm Oncology treatment of hypercalcemia of malignancy, treatment of MM and bone metastatis from solid tumorsNovartis Market Active estradiol Vivelle sm AIID the prevention of osteoporosisNovartis Market Active LDK378 Zykadia ALK sm Oncology NSCLC, neuroblastomaNovartis P1 Active VAY736 MorphoSys BAFF-R mAb Oncology CLL

sphingosine 1-phosphate receptor

Novartis P1 Active TAS266 Ablynx Death receptor 5 nanobody Oncology cancerNovartis P1 Active Ensemble IL-17A millamolecule AIIDNovartis P1 Active MEK162 ARRY-438162 MEK1/2 sm Oncology solid tumorNovartis P1 Active BKM120 PI3K sm Oncology solid tumorNovartis P1 Active LFA102 Xoma prolactin receptor mAb Oncology breast, prostateNovartis P2 Active CAD106 Abeta vaccine CNS ADNovartis P2 Active BYM338 bimagrumab MorphoSys Activin receptor type IIA mAb sIBMNovartis P2 Active LCI699 Aldosterone synthase sm metabolic disordCushing'sNovartis P2 Active LFF571 Bacterial elongation factor Tu(EFTu) Infection Clostridium difficileNovartis P2 Active LGX818 BRAF sm Oncology solid tumorNovartis P2 Active LEE011 Astex CDK4/6 sm OncologyNovartis P2 Active BHQ880 MorphoSys DKK-1 mAb Oncology MMNovartis P2 Active AUY922 NVP-AUY922 Vernalis hsp90 sm Oncology solid tumorNovartis P2 Active QGE031 IgE mAb AllergyNovartis P2 Active TKI258 dovitinib multi-kinase sm Oncology RCCNovartis P2 Active KAE609 n/a sm Infection malariaNovartis P2 Active BCT197 n/a Respiratory COPDNovartis P2 Active QAW039 n/a Respiratory asthmaNovartis P2 Active LGT209 Kalobios PCSK-9 mAb CVS HypercholesterolemiaNovartis P2 Active BEZ235 NVP-BEZ235 PI3K sm Oncology solid tumorNovartis P2 Active LIK066 SGLT2 sm Diabetes T2DMNovartis P2 Active LDE225 erismodegib sonidegib SMO(Smoothened) sm Oncology basal cell carcinomaNovartis P3 Active LCZ696 valsartan +AHU-377 angiotensin receptor+neprilysin sm CVS HypertensionNovartis P3 Active LCQ908 diacylglycerol acyl transferase-1(D sm Familial chylomicronemia syndromeNovartis P3 Active LBH589 panobinostat HDAC sm AIID MMNovartis P3 Active AIN457 secukinumab IL-17 mAb AIID psoriasis, MS, RANovartis P3 Active AFQ056 mavoglurant metabotropic glutamate receptor sm Rare disease Fragile X syndromeNovartis P3 Active BAF312 sm AIID MSNovartis P3 Active PKC412 midostaurin Flts and others sm Oncology AML, MDSNovartis PC Active clostrium difficle vaccine Infection Clostridium difficileNovartis Active BGS649 aromatase sm OHHNovartis Active CTL019 CD-19 CART Oncology LeukemiaNovartis Active HCD122 lucatumumab CD-40 mAbNovartis Active DEB025 Debio 025 alisporivir cyclosphilin sm Infection HCVNovartis Active LJM716 MorphoSys HER3 mAb Oncology breast cancerNovartis Active AT355 NOGO-A mAb spinal cord injuryNovartis Active BYL719 PI3K Oncology solid tumorNovartis Active RLX030 serelaxin relaxin receptor biologics CVS Acute heart failure

Novimmune Dis Active NI-1701 CD-47 and CD-19 mAb(bispecificOncology Acute lymphocytic leukemia, NHLNovimmune Dis Active NI-1601 OncologyNovimmune P1 Active NI-1401 Genentech IL-17 mAb AIIDNovimmune P1 Active NI-0101 TLR4 mAb AIID inflammationNovimmune P1 Active NI-0701 CCL5 (Rantes) mAb AIID inflammation

sphingosine 1-phosphate receptor

Novimmune P2 Active NI-0501 Interferon gamma mAb Oncology hemophagocytic lymphohistiosytosisNovimmune P2 Active NI-0401 CD3 epsilon mAb AIID transplantNovimmune P2 Active NI-0801 CXCL-10 mAb Primary bilary cirrhosis (PBC)Novimmune PC Active NI-1201 IL-6R mAb(bispecificAIID inflammation

Novo Nordisk P1 Active NN8210 C5aR-215 mAb AIID RANovo Nordisk P1 Active NN8765 Innate Pharma NKG2A mAb AIID RANovo Nordisk P2 Active NN8209 C5aR-151 mAb AIID RANovo Nordisk P2 Active NN8226 IL-20 mAb AIID RANovo Nordisk P2 Active NN8828 IL-21 mAb AIID RA

NOXXON P2 NOX-E36 CCL2 aptamer Diabetes diabetic nephropathyNOXXON P2 NOX-A12 CXCR4 aptamer Oncology MM, CLL, glioblastomaNOXXON P2 NOX-H94 hepcidin aptamer Nephrology amemiaNOXXON PC NOX-G15 glucagon aptamer Diabetes T2DM

OncoEthix P1 Active OTX015 MitsubishiTanabe bromodomain sm OncologyOncoGenix P2 Active OGX-427 hsp27 NAT Oncology metastaic bladder cancerOncoGenix P3 Active OGX-011 custirsen Teva clusterin(=apolipoprotein J) NAT Oncology Castration-resistant prostate cancer OncoGenix PC Active OGX-225 IGFBP-2 NAT Oncology

Oncomatryx PC Active Cystatin-C TGFβ by binding to TGbβRII protein Oncology breast cancerOncoMed P1 Active OMP-21M18 demcizumab DLL-4 mAb Oncology solid tumorsOncoMed P1 Active Bayer Fzd8 mAb OncologyOncoMed P1 Active OMP52M51 GSK Notch1 mAb OncologyOncoMed P1 Active OMP-59R5 GSK Notch2/3 mAb OncologyOncoMed P1 Active vantictumab Bayer Tzd7 mAb OncologyOncoMed PC Active DLL and VEGF mAb OncologyOncoMed PC Active RSPO-LGR pathway mAb OncologyOnconova P1 Active ON 013105 Cyclin D sm Oncology refractory lymphoma and ALLOnconova P3 Active rigosertib PI3K and PLK sm Oncology MDS(Myelodysplastic syndrome), p

Oncos Therapeutics P1 Active ONCOS-102 a capsid-modified GM-CSF armed onNAT OncologyOncotherapy P1 Active OTS167 MELK sm OncologyOncothyreon P2 Active PX-866 PI3K sm OncologyOncoVenture PC Active AITR mAb Oncology melanoma, blood cancerOncoVenture PC Active Catholic Univ Bcr-Abl sm Oncology hematological malignanciesOncoVenture PC Active KRIBB DLK-1 fusion protein OncologyOncoVenture PC Active KRIBB DLK-1 mAb OncologyOncoVenture PC Active G-749 OscoTec Flt3 sm Oncology AMLOncoVenture PC Active Abxign HGF mAb Oncology LeiomyosarcomaOncoVenture PC Active CKD tubulin sm Oncology solid tumors

Ono P1 Active ONG-WG-307 Oncodesign Btk sm Oncology B cell malignanciesOnyx/Amgen Market Active carfilzomib Kyprolis Proteolix proteasome sm Oncology MM, Onyx/Amgen Market Active sorafenib Nexavar Bayer VEGFR, PDGFR, C-Raf sm Oncology RCC, HCOnyx/Amgen P1 Active oprozomib 20S proteasome sm Oncology hematological malignancyOnyx/Amgen P3 Active palboclclib Pfizer CDK4/6 sm Oncology breast cancerOnyx/Amgen PC Active ONX 0914 immunoproteasome sm AIID RA, IBD, Lupus

Opsona Therapeutics P2 Active OPN-305 TLR2 mAb AIID kidney transplant failure or rejectionOrion P2 Active ORM-1274 Janssen alpha2c adrenoreceptor (AR) sm CNS AD

Oscotec Dis Active LRRK2 sm CNS Huntington'sOscotec PC Active SYK sm AIID RA

OSE Pharma P3 Active Texopi T cell therapy cell therapy Oncology NSCLCOSI Market Active erlotinib Tarceva EGFR TK sm Oncology NSLCL, pancreatic cancer

Otsuka P2 Active POC-6535 tetomiast sm Respiratory COPDOxiGene P1 Active C4P combretastatin fosbretabulin Zybrestat microtubule destablizing agent sm Oncology anaplastic thyroid cancerPepscan

Peregrine P2 Active bavituximab phosphatidylserine mAb Oncology lung, pancreaticPeregrine P2 Active mAb TNT Cotara mAb Oncology recurrent glioblastoma

Pfizer P3 Terminated bapineuzumab Abeta mAb CNS ADPfizer P3 Terminated CMC-544 inotuzumab ozogamicin Wyeth CD-22 ADC Oncology NHLPfizer P3 Terminated CP-529,414 torcetrapid CETP sm CVS dyslipidemiaPfizer Terminated Terminated semaxanib Tlk-1/KDR, VEGFR sm OncologyPfizer P3 Clinical Hold tanezumab NGF mAb CNS OA signs and symptomsPfizer Market Active PF-02341066 crizotinib Xalkori ALK(EML4-AKK), cMet sm Oncology Previously treated ALK-positive Advanced NSCLCPfizer Market Active SKI-606 bosutinib Bosulif Wyeth Bcr-Abl tyrosine kinase, Src sm Oncology autosomal dominant polycystic kidney disease, CMLPfizer Market Active gemtuzumab ozogaMylotarg CD-33 ADC Oncology AMLPfizer Market Active diclofenac/misoproArthrotec COX-1/2 sm OA,RAPfizer Market Active apixaban Eliquis Factor Xa sm CVS venous thromboembolism treatmentPfizer Market Active sirolimus Rapamune FBKP12/mTOR sm AIID renal transplantPfizer Market Active temsirolimus Torisel FKBP 12/mTOR sm Oncology RCCPfizer Market Active tofacitinib Xeljanz JAK sm AIID RA, psoriasis, UCPfizer Market Active sutent multi-kinase sm OncologyPfizer Market Active sunitinib Sutent PDFGR alpha/beta, Kit, Flt3 sm Oncology RCC, GIST, pancreatic neuroendocrine tumorsPfizer Market Active AG013736 axitinib Inlyta VEGFR1/2/3, PDGFR, cKit sm Oncology RCCPfizer Market Active conjugated estrog Premarin sm Oncology the prevention of postmenopausal osteoporosis and treatment of Pfizer Market Active sulfasalazine ER Azulfidine EN smPfizer P1 Active PF-05236812 AAB-003 Janssen Abeta protein inhibitor mAb CNS ADPfizer P1 Active PF-03446962 ALK1 mAb Oncology cancerPfizer P1 Active PF-04958242 AMPA glutamate receptor sm CNS SchizophreniaPfizer P1 Active PF-05082566 CD-137 (or 4-1BB) mAb Oncology cancerPfizer P1 Active PF-05280586 rituximab CD-20 biosimilar AIID RAPfizer P1 Active F8-IL10 Dekavil Philogen Fc-IL10 fusion protein AIID RAPfizer P1 Active PF-03084014 gamma secretase sm Oncology cancerPfizer P1 Active PF-06252616 GDF-8 mAb Rare disease muscular dystrophiesPfizer P1 Active PF-05280014 tratuzumab HER2 biosimilar Oncology breast cancerPfizer P1 Active PF-06444752 IgE vaccine Respiratory asthma, COPDPfizer P1 Active PF-0325901 PD-0325901 MEK sm Oncology cancerPfizer P1 Active PF-05231023 n/a biologics Diabetes T2DMPfizer P1 Active PF-06342674 RN168 n/a biologics Diabetes T1DMPfizer P1 Active PF-06282999 n/a sm CVS acute coronary syndrome

Pfizer P1 Active PF-05175157 n/a sm Diabetes T2DMPfizer P1 Active PF-05402536 n/a vaccine CNS smoking cessationPfizer P1 Active PF-06273340 n/a CNS Acute and chronic painPfizer P1 Active PF-06305591 n/a CNS painPfizer P1 Active PF-05089771 Icagen Nav1.7 sm CNS painPfizer P1 Active PF-03715455 p38 MAP kinase sm Respiratory COPDPfizer P1 Active PF-05280602 biologics Rare disease HemophiliaPfizer P1 Active PF-04449913 SMO(Smoothened) sm Oncology AMLPfizer P1 Active PF-06687859 n/a Rare disease spinal muscular atrophyPfizer P1 Active PF-06425090 vaccine Infection Clostridium difficile colitisPfizer P2 Active PF-05212377 SAM-760 5-HT6 receptor sm CNS ADPfizer P2 Active PF-05236806 ACC-001 Abeta vaccine CNS AD

Pfizer P2 Active PF-04634817 CCR2/5 sm Nephrology Diabetic nephropathy

Pfizer P2 Active PF-04523655 Silence TheapeuticCD-22 NAT Opthalmology diabetic macular oedemaPfizer P2 Active PF-06473871 EXE 001 ISIS CTGF(connective tissue growth factNAT Dermatology Dermal scarringPfizer P2 Active PF-04171327 glucocorticoid receptor sm AIID RAPfizer P2 Active PF-04937319 Glucokinase sm Diabetes T2DMPfizer P2 Active IMA-638 anrukinzumab Wyeth IL-13 biologics AIID UCPfizer P2 Active PF-04236921 IL-6 mAb AIID Crohn's Disease, LupusPfizer P2 Active PD-0360324 M-CSF biologics AIID Lupus, SarcoidosisPfizer P2 Active PF-00547659 MAdCAM(mucosal addressin cell adbiologics AIID UC, Crohn's diseasePfizer P2 Active PD-325901 MEK1/2 sm Oncology breast, colon, melanomaPfizer P2 Active PF-05285401 Multistem n/a Stem cell AIID UCPfizer P2 Active tanezumab NGF mAb CNS cancer painPfizer P2 Active PNU-100480 sutezolid oxazolidinone sm Infection tuberculosisPfizer P2 Active PH-797804 p38 MAP kinase sm Respiratory COPDPfizer P2 Active PF-00489791 PDE-5 sm Nephrology Diabetic nephropathyPfizer P2 Active PF-05212384 PI3K alpha/gamma +mTOR sm Oncology endometrial cancerPfizer P2 Active PF-04950615 RN316 Proprotein convertase subtilisin kexmAb CVS HypercholesterolemiaPfizer P2 Active PF-0449470 TTP488 TransTech RAGE sm CNS ADPfizer P2 Active axitinib Inlyta VEGF tyrosine kinase sm Oncology liver cancerPfizer P2 Active PF-06460031 GMI-1070 n/a Rare disease Vaso-occlusive crisis associated with sickle cell diseasePfizer P2 Active PF-06290510 4Antigen S.aureus Vaccine(SA4Ag) vaccine Infection S. aureusPfizer P2 Active PF-03049423 CNS stroke recoveryPfizer P3 Active PF-05335810 RN-316 bococizumab PCSK-9 mAb CVS HypercholesterolemiaPfizer P3 Active PF-04971729 ertugliflozin Merck SGLT2 sm Diabetes T2DMPfizer P3 Active PF-00299804 dacomitinib pan-ErbB sm Oncology NSCLCPfizer P3 Active Zithromax/chloroquine 5-OS ribosome sm Infection malariaPfizer P3 Active pregabalin Lyrica alpha2 delta ligand CNS peripheral neuropathic painPfizer P3 Active PD-0332991 palbociclib CDK4/6 sm Oncology Breast cancer, Pfizer P3 Active mu-opiod receptor sm CNS painPfizer P3 Active PF-05212366 MnB rLP2086 vaccine Infection adolescent and young adult meningitisPfizer PC Active PF-4693627 mPGES 1 sm AIID inflammation and pain

recombinant Factor VIIa Variant

Pfizer Reg Active Viviant estrogen receptor sm Osteoporosis treatment and preventionPfizer Reg Active Remoxy mu-opiod receptor sm CNS painPfizer Reg Active tafamidis meglumine Transthyretin(TTR) dissociation sm Rare disease transthyretin fmalial amyloid polyneuropathyPfizer Reg Active bazedoxifene-conjugated estrogens

Pharmascience P1 Active AEG40826 IAP sm OncologyPharmascience PC Active AEG42504 Btk sm Oncology

Phenex AG P2 Active PX-104 Roche FXR sm Metabolic disor NASH/NAFLD/liver fibrosisPhenoquest AG PC Active PQ001 TMEFF2 (tumoregulin) mAb CNS AD, depression

Pierre Fabre PC Active AUNP-12 Aurigene (Indian PD-1 peptide OncologyPiramal P1 Active BAY 85-8101 sm CNS ADPiramed P1 Active GDC-0941 PI3K sm OncologyPlexxikon P1 Active PLX5622 FGF-1 receptor sm AIID RAPlexxikon P2 Active PLX3397 CSF-1R sm Oncology glioblastoma

Point Therapeutics P3 Terminated Talabostat FAP sm Oncology pancreatic cancerPolyphor P2 Active POL6326 CXCR4 peptide Oncology leukemia, MMPolyphor P2 Active POL7080 Roche Pseudomonas aeruginosa sm Infection Pseudo. Aeruginosa speficicPolyphor PC Active POL6014 Neutrophil elastase sm Respiratory COPD, CF, AATD (alpha-1-antityrpsin deficiency)Portola P1 Active PRT2070 Syk sm Oncology NHLPortola P2 Active PRT064445 andexanet alpha Factor Xa antidote Biologics CVS thrombosisPortola P3 Active betrixaban Factor Fa sm CVSPraecis Market Active abarelix Plenaxis gonadotropin-releasing hormone resm Oncology advanced prostate cancer

Principia PC Active BTK sm AIIDPrincipia PC Active FGFR sm OncologyProgenics P2 Active PSMA-ADC PSMA ADC Oncology CRC, prostatePromegior P2 Active PRM-151 recombinant Pentraxin-2 protein fibrosis

Prometheus LaboratoriesMarket Active interleukin 2 Proleukin interleukin 2 enzyme Oncology metastatic melanomaProsensa P1 Active PRO045 dystrophin RNA transcript NAT DMDProsensa P2 Active PRO-044 Dystrophin NAT Rare disease DMDProsensa P2 Active PRO044 dystrophin RNA transcript NAT DMDProsensa P3 Active drisapersen returned from GSKdystrophin RNA transcript NAT DMDProsensa PC Active PRO052 dystrophin RNA transcript NAT DMDProsensa PC Active PRO053 dystrophin RNA transcript NAT DMDProsensa PC Active PRO055 dystrophin RNA transcript NAT DMDProsensa PC Active prosect dystrophin RNA transcript NAT DMDProsensa PC Active RPO135 NAT myotonic dystrophy(DM1)Prosensa Active PRO289 NAT CNS Huntington's Disease

ProStrakan Market Active granisetron Sancuso 5-HT3 sm Oncology nausea and vomiting associated with chemoProtagonist Active

Protalex P1 Active PRTX-100 staphylococcal proteinA biologics AIID RAProthena PC Active PRX002 Roche alpha synuclein mAb CNS PD

PTC P3 Active PTC124 Ataluren Genzyme premature stop codon sm Rare disease Cystic fibrosisPuma Biotechnology P3 Active PB272 neratinib HER2 TK, EGFR TK sm Oncology breast cancer

Quark Active

Ra Pharmaceutical ActiveReceptos Dis Active GLP1 receptor sm Diabetes T2DMReceptos P1 Active RPC4046 Interleukin-13 mAb AIID EoEReceptos P2 Active RPC1063 S1P1R sm AIID RMS(relapsing MS), IBD

Regeneron Clinical Hold REGN475 fasinumab Sanofi NGF mAb CNS painRegeneron n/a Active REGN1400 ErbB3 mAb Oncology advanced malignanciesRegeneron n/a Active REGN1033 GDF-8 mAb metabolic disorderRegeneron n/a Active REGN846 n/a mAb AIID Atopic dermatitisRegeneron n/a Active REGN1154 n/a mAb n/aRegeneron n/a Active REGN1500 n/a mAb n/aRegeneron P1 Active REGN910 nesvacumab Sanofi angiopoietin2 mAb Oncology advanced malignanciesRegeneron P1 Active REGN421 enoticumab Sanofi DLL-4 mAb Oncology advanced malignanciesRegeneron P3 Active REGN88 sarilumab IL-6 mAb AIID RA

Regulus PC Active miR-10b NAT Oncology glioblastomaRegulus PC Active RG-101 GSK miR-122 NAT Infection HCVRegulus PC Active Sanofi miR-21 NAT Fibrosis (kidney)Regulus PC Active miR-221 NAT Oncology HCCRegulus PC Active AstraZeneca miR-33 NAT CVS atherosclerosisRegulus PC Active NAT Oncology

Resverlogix P2 Active RVX-208 bromodomain sm CVS artherosclerosisRevalesio P1 Active RNS60 Voltage-gated ion channel sm CVS AD, MSRevalesio P1 Active RNS60 Voltage-gated ion channel sm Respiratory AsthmaRevalesio P1 Active RNS60 Voltage-gated ion channel sm CVS acute myocardial infarctionRevance P1 Active RT002 SNARE25 protein CNSRevance P3 Active RT001 SNARE25 protein CNS crow's feet line, hyperhidrosisRexahn P2 Active Archexin Akt1 NAT Oncology pancreatic cancerRexahn PC Active RX-3117 Teva DNA synthesis sm Oncology pancreatic cancerRexahn PC Active RX-5902 p68 RNA helicase sm OncologyRhythm P1 Active RM-493 MC4R peptide Diabetes T2DM

Rigel P2 Active R343 syk sm Respiratory AsthmaRigel P2 Active R333 syk/jak sm AIID lupusRigel P3 Active R768 fostamatinib syk sm AIID RA, and other autoimmune disease

Roche P1 Terminated RG7129 beta secretase sm CNS ADRoche P3 Terminated JTT-705 dalcetrapid CETP sm CVS HypercholesterolemiaRoche P3 Terminated RG1439 aleglitazar PPAR alpha/gamma sm Diabetes T2DMRoche Dis Active TYK2 sm AIIDRoche Market Active granisetron Kytril 5-HT3 sm Oncology nausea and vomiting associated with chemoRoche Market Active vemurafenib Zelboraf A/B/C-raf, B-raf (V600E) sm Oncology BRAFV600E (+) melanomaRoche Market Active efalizumab Raptiva Merck Serono CD-11a mAb AIID PsoriasisRoche Market Active rituximab Rituxan/MabTher Biogen Idec CD-20 mAb Oncology NHLRoche Market Active capecitabine Xeloda DNA synthesis sm Oncology advanced breast cancer, mCRCRoche Market Active tratuzumab Herceptin Her2 (ErbB2) mAb Oncology Breast cancerRoche Market Active daclizumab Zenapax IL-2R alpha (CD-25) mAb AIID transplant rejection

Roche Market Active RG1569 tocilizumab/atiliz Actemra Chugai IL-6 R mAb AIID RA, systemic sclerosis etcRoche Market Active RG3616 GDC-0449 vismodegib Erivedge Curis SMO(Smoothened) sm Oncology operable basal cell carcinomaRoche Market Active bevacizumab Avastin VEGFR mAb Oncology CRCRoche Market Active RG1594 ocrelizumab Gazyvaro BiogenIdec CD-20 mAb AIID MSRoche P1 Active RG7440 AKT sm Oncology solid tumorRoche P1 Active RG7853 Chugai ALK sm Oncology NSCLCRoche P1 Active RG7221 angiopoietin2+VEGFA mAb OncologyRoche P1 Active RG7204 vemurafenib Zelboraf BMX, Plexxikon BRAF sm Oncology melanomaRoche P1 Active RG7212 CD-255(TWEAK)Roche P1 Active RG7356 Arius CD-44 mAb Oncology solid tumorRoche P1 Active RG7602 Array BioPharma checkpoint kinase (Chk1)1 sm Oncology solid tumor or lymphomaRoche P1 Active RG7741 checkpoint kinase (Chk1)1 sm Oncology solid tumor or lymphomaRoche P1 Active RG7155 CSF-1R mAb Oncology solid tumorRoche P1 Active RG7444 FGFR-3 mAb Oncology MMRoche P1 Active RG1662 GABA A receptor alpha (GABRA5) sm CNS congitive disorderRoche P1 Active RG7697 GLP-1 and GIP peptide Diabetes T2DMRoche P1 Active RG7112 p53-HDM2 sm Oncology solid and hematological tumorsRoche P1 Active RG7388 p53-HDM2 sm Oncology solid and hematological tumorsRoche P1 Active RG7116 HER3 mAb Oncology solid tumorRoche P1 Active RG7624 Chugai IL-17 mAb AIID RA, and other autoimmune diseaseRoche P1 Active Chugai IL-6 R mAb AIID RARoche P1 Active RG7167 Chugai MEK1/2 sm Oncology solid tumorRoche P1 Active RG7304 MEK1/2 sm Oncology solid tumorRoche P1 Active RG7420 MEK1/2 sm Oncology solid tumorRoche P1 Active RG7458 Seattle Genetics n/a ADC Oncology ovarian cancerRoche P1 Active RG7598 Seattle Genetics n/a ADC Oncology MMRoche P1 Active RG7599 Seattle Genetics n/a ADC Oncology NSCLC, ovarian cancerRoche P1 Active RG7600 Seattle Genetics n/a ADC Oncology pancreatic cancer, ovarian cancerRoche P1 Active RG7636 Seattle Genetics n/a ADC Oncology metastatic melanomaRoche P1 Active CIM331 Chugai n/a mAb AIID Atopic dermatitisRoche P1 Active RG7446 MPDL3280A PD-L1 mAb Oncology NSCLC, mMelanoma, solid tumorsRoche P1 Active RG7203 PDE-10A sm CNS SchizophreniaRoche P1 Active RG7604 PI3K sm Oncology solid tumorRoche P1 Active Chugai PI3K class I sm OncologyRoche P1 Active RG7450 Seattle Genetics STEAP1 ADC Oncology prostate cancerRoche P1 Active RG7314 V1A vasopressin receptor sm CNS autismRoche P1 Active Chugai WT1 vaccine OncologyRoche P2 Active RG7412 crenezumab AC Immune Abeta mAb CNS ADRoche P2 Active RG1450 gantenerumab Morphosys Abeta mAb CNSRoche P2 Active RG7601 CDC-0199 AbbVie Bcl-2 sm Oncology relapsed/refractory CLLRoche P2 Active RG7413 etrolizumab beta 7 integrin subunit mAb AIID UCRoche P2 Active RG7593 CD-22 ADC Oncology hematological malignancies, prostate cancerRoche P2 Active RG7596 CD-79b ADC Oncology hematological malignancies. DLBCL and follicular NHL

Roche p2 Active RG7790 setrobuvir NS5b RAN polymerase sm Infection HCVRoche P2 Active RG6013 ACE910 Factor IXa and X mAb CVS Hemophilia ARoche P2 Active DCDS3410A CD-79b mAb Oncology NHLRoche P2 Active RG7414 parsatuzumab EGFL7 mAb Oncology solid tumorRoche P2 Active RG7160 GA201 imgatuzumab EGFR mAb Oncology solid tumorRoche P2 Active RG7686 Chugai glypican-3 mAb Oncology metastatic HCCRoche P2 Active RG7597 HER3/EGFR mAb Oncology metastatic epithelial tumorsRoche P2 Active RG7449 quilizumab IgE mAb Respiratory asthmaRoche P2 Active RG7415 rontalizumab interferon alpha mAb AIID Systemic lupus erythematosusRoche P2 Active pateclizumab LT alpha mAb AIID RARoche P2 Active RG1577 MAO-B sm CNSRoche P2 Active RG7227 danoprevir NS3/4A protease sm Infection HCVRoche P2 Active RG7128 mericitabine Pharmasset NS5B polymerase sm Infection HCVRoche P2 Active RG1512 inclacumab Genmab P-selectin mAb CVS acute coronary syndromeRoche P2 Active RG7652 MPSK3169A PCSK-9 mAb CVS HypercholesterolemiaRoche P2 Active RG7321 pictilisib PI3K sm Oncology solid tumorRoche P2 Active RG7422 PI3K + mTOR kinase sm Oncology solid tumor, NHLRoche P2 Active RG7667 sm Infection CMVRoche P3 Active RG7159 GA101 obinutuzumab BiogenIdec CD-20 mAb Oncology NHL, CLLRoche P3 Active RG3638 onartuzumab cMet mAb Oncology gastric cancer, non-SQ NSCLCRoche P3 Active SST arbaclofen Seaside TherapeutGABA-B receptor sm CNS autism spectrum disorders, fragile X syndromeRoche P3 Active RG-3648 omalizumab Xolair Novartis IgE mAb AIID chronic idiopathic urticariaRoche p3 Active RG3637 lebrikizumab IL-13 mAb AIID severe asthmaRoche P3 Active RG1678 bitopertin NMDA receptor sm CNS schizoprenia, obsessive compulsive disorderRoche P3 Active tofogliflozin SGLT2 sm Diabetes T2DMRoche P3 Active RG3806 octreolin somatostatin peptide AIID acromegalyRoche P3 Active sodium hyaluronatSuvenyl Chugai AIID enthesopathyRoche PC Active RN486 Btk sm AIID RA, immune hypersensitivityRoche PC Active Muc-16 ADC Oncology Ovarian cancerRoche Reg Active RG3502 T-MD1 Kadcyla HER2 ADC OncologyRoche Reg Active RG1273 pertuzumab Perjeta HER2 mAb Oncology HER2 positive breast cancer, gastric cancer, Roche Terminated Active RG7090 metabotropic glutamate receptor sm CNS treatment-resistant depressionRoche Active RG1578 metabotropic glutamate 2/3 receptors CNS depressionRoche Active RG7666 GDC-0084 PI3K sm Oncology progressive or recurrent high grade glioma

Rxi P1 Active Rxi-109 CTGF NAT Dermatology Dermal scarringSalix Market Active Ruconest complement system esterase C1 sm Rare disease Acute swelling in hereditary angioedema

Sanofi Market Active Anzemet 5-HT3 sm Oncology emesis, prevention of nausea and vomitingSanofi Market Active ISIS 301012 mipomersen Kynamro Apolipoprotein B-100 NAT CVS, rare diseas Severe HeFHSanofi Market Active AMD3100 plerixafor Mozobil CXCR4 sm Oncology stem cell mobilizerSanofi Market Active oxaliplatin Eloxatin Debio DNA synthesis sm Oncology CRC in combination with 5-FU/leucovorinSanofi Market Active docetaxel Taxotere mitotic inhibitor sm Oncology advanced or metastatic breast cancerSanofi Market Active clofarabine Clolar Genzyme purine antimetabolite sm Oncology acute lymphoblastic leukemia in pediatric patientsSanofi Market Active rasburicase Ellteck urate oxidase enzyme repla Oncology management of plasma uric acid levels in adult with malignancies

Sanofi Market Active Arava sm RASanofi Market Active riluzole Rilutek TTX-sensitive sodium channel sm CNS ALS (Lou Gehrig)Sanofi P1 Active SAR307746 angiopoietin2+VEGFA mAb Oncology solid tumorsSanofi P1 Active SAR566658 CA6 (=Mucin1) ADC Oncology ovarian and breast cancerSanofi P1 Active SAR650984 CD-38 mAb Oncology hematological malignanciesSanofi P1 Active SAR125844 cMet sm Oncology solid tumorsSanofi P1 Active SAR113244 CXCR5 mAb AIID Systemic lupus erythematosusSanofi P1 Active SAR153192 DDL-4 mAb Oncology solid tumorsSanofi P1 Active SAR566658 DS6 ADC Oncology solid tumorsSanofi P1 Active GZ402665 rhASM GCS sm Rare disease Fabry diseaseSanofi P1 Active SAR405838 MI-773 Ascenta Therapeutp53-HDM2 sm Oncology solid tumorsSanofi P1 Active SAR252067 LIGHT mAb AIID UC, Crohn's diseaseSanofi P1 Active P. aeruginosa mAb infection ventilator-associated pneumoniaSanofi P1 Active SAR127963 P75 receptor CNS Trauma brain injurySanofi P1 Active SAR260301 PI3K beta sm Oncology PTEN-deficient tumorsSanofi P1 Active SAR228810 protofibrillar AB mAb CNS ADSanofi P1 Active SAR407899 Rho kiase sm CVS Pulmonary hypertensionSanofi P1 Active rotavirus vaccine Infection rotavirusSanofi P1 Active S. pneumonia vaccine infectionSanofi P1 Active SAR126119 TAFI alpha sm CNS Acute ischemic strokeSanofi P1 Active GZ402674 topo 1 sm Oncology solid tumorsSanofi P1 Active tuberculosis vaccine Infection TuberculosisSanofi P1 Active Gz404477 AAV-hAADC Gene therapy CNS PDSanofi P1 Active GZ402633 sFLT-01 Gene therapy Opthalmology AMDSanofi P1 Active RetinoStat Gene therapy Opthalmology AMDSanofi P1 Active StarGen Gene therapy Opthalmology Stargardt diseaseSanofi P1 Active UshStat Gene therapy Rare disease Usher syndrome BSanofi P1 Active SAR391786Sanofi P1 Active SAR404460 Pre-sarcopeniaSanofi P2 Active SAR3419 CD-19 ADC Oncology NHL, ALSanofi P2 Active SAR256212 MM121 Merrimack ErbB3 mAb Oncology Breast cancer, platinum-resistant Sanofi P2 Active lixisenatide + lantus GLP-1 + insulin Diabetes T2DMSanofi P2 Active SAR110894 H3 receptor sm CNS ADSanofi P2 Active SAR113945 IKK beta sm AIID OASanofi P2 Active SAR231893 REGN668 Regeneron IL-4R alpha mAb RespiratorySanofi P2 Active SAR302503 TG101348 fedratinib TargeGen JAK2 sm Oncology Polycythemia vera, ruxolitinib resiSanofi P2 Active SAR245408 XL147 PI3K sm Oncology Breast cancerSanofi P2 Active SAR245409 XL765 PI3K and mTOR sm Oncology NHLSanofi P2 Active SAR279356 F598 PNAG mAb infection serious infectionsSanofi P2 Active fresolumimab TFG beta mAb fibrosisSanofi P2 Active SAR292833 GRC15300 TRPV3 sm CNS painSanofi P2 Active cabazitaxel Jevtana tubulin sm Oncology small cell lung cancerSanofi P2 Active SAR339658 VLA2 AIID inflammatory bowel disease

Sanofi P2 Active FDC prednisolone/cyclosporine sm AIID Allergic conjunctivitisSanofi P2 Active Meninge ACYW conj. vaccine Infection meningococcusSanofi P2 Active ACAM-Cdiff vaccine Infection Clostridium difficileSanofi P2 Active SAR100842 AIID skin manifestation of sclerodermaSanofi P2 Active ferroquine infection malariaSanofi P2 Active Rabies VRVg vaccine Infection RabbiesSanofi P3 Active SAR156597 dupilumab IL-4/IL-13 bispecific mAbAIID asthma, atopic dermatitisSanofi P3 Active otamixaban Factor Xa sm CVS ACSSanofi P3 Active eliglustat tartrate Glucosylceramide synthetase sm Rare disease Gaucher diseaseSanofi P3 Active SAR153191 sarilumab IL-6 R mAb AIID RASanofi P3 Active SAR302503 TG101348 JAK2 sm Oncology MyeolofibrosisSanofi P3 Active BSI-201 iniparib PARP sm Oncology TNBC, NSCLC, Ovarian, glioblastomaSanofi P3 Active cabazitaxel Jevtana tubulin sm Oncology prostate cancerSanofi P3 Active BSI-201 iniparib sm Oncology Suamous NSCLCSanofi P3 Active Dengue vaccine Infection mild-to-severe dengue fever Sanofi P3 Active Quadracel vaccine InfectionSanofi P3 Active PR5I vaccine Infection DPT-HepB-Polio-HibSanofi P3 Active SAR399063 ? Pre-sarcopeniaSanofi P3 Active Fluzone QIV ID vaccine InfectionSanofi Reg Active alemtuzumab Lemtrada CD-52 mAb AIID MSSanofi Reg Active lixisenatide Lyxumia GLP-1 peptide Diabetes T2DMSanofi Reg Active teriflunomide Aubagio AIID relapsing MSSanofi Registration Active SAR236553 REGN727 alirocumab Regeneron PCSK-9 mAb CVS hypercholesterolemiaSanofi Registration Active Fluzone QIV IM vaccine Infection influenzaSanofi Registration Active VaxiGrip QIV IM vaccine Infection influenza

Santaris Dis Active Enzon beta-catenin NAT Oncology cancerSantaris P1 Active ENZ-4176 Enzon androgen receptor NAT Oncology cancerSantaris P1 Active SPC-4955 Apolipoprotein B-100 NAT CVSSantaris P1 Active ENZ-2968 Enzon HIF-1 alpha NAT Oncology cancerSantaris P1 Active SPC-5001 PCSK-9 NAT CVS hypercholesterolemiaSantaris P1 Active ENZ-3042 Enzon survivin NAT Oncology cancerSantaris P2 Active SPC-3649 miravirsen miR-122 NAT Infection HCVSantarus P1 Active SAN-300 VLA-1 NAT AIID RASarepta Dis Active NAT Infection XDR-TBSarepta P1 Active AVI-7288 NAT Infection Marburg virus infectionSarepta P1 Active AVI-7100 NAT Infection InfluenzaSarepta P2 Active AVI-4658 eteplirsen dystrophin NAT Rare disease Duchenne musclular dystrophySarepta P2 Active AVI-4658 eteplirsen dystrophin NAT Rare disease DMDSareum Dis Active FLT4 sm OncologySareum PC Active FLT3+Aurora sm Oncology myeloid leukemiaSareum PC Active TYK2 kinase sm AIID PsoriasisSareum Dis Chk1 sm OncologySareum Dis TYK2 kinase sm AIID RA

Sareum PC Aurora + FLT3 sm Oncology myeloid leukemiaSARomics Dis Active CK2 and Pim-1 sm AIID RA

Savient Pharma Market Active pegloticase Krystexxa recombinant uricase enzyme Chronic gout (hyperuricemia)Savira Dis Active Roche influenza virus sm Oncology

Schering Market Active flutamide Eulexin androgen receptor sm Oncology prostate cancerSeattle Genetics ? Active SGN-33 lintuzumab CD-33 ADC OncologySeattle Genetics Market Active brentuximab vedotAdcetris Takeda CD-30 mAb Oncology Anaplastic large cell lymphoma, Hodgkin lymphomaSeattle Genetics P1 Active SGN-CD33A CD-33 ADC Oncology AMLSeattle Genetics P1 Active SGN-75 vorsetuzumab mafodotin CD-70 ADC Oncology prostate cancerSeattle Genetics PC Active SGN-19A CD-19 ADC Oncology B cell lymphomaSeattle Genetics PC Active LIV-1 ADC Oncology breast cacnerSeattle Genetics Active CD-133 Oncology gastric and hepatocellular cancers

Selexys P1 Active SelG1 mAb sickle cell anemiaSelvita Dis Active SEL300 cancer metabolism sm OncologySelvita Dis Active SEL141 DYRK1A sm CNS ADSelvita Dis Active SEL201 MNK1/MNK2 sm OncologySelvita Dis Active SEL212 NALP3 inflammasome sm AIIDSelvita PC Active SEL24 Flt3/Pim sm Oncology

Sequella P2 Active sutezolid oxazolidinone sm infection tuberculosisSequella P2 Active SQ109 sm infection tuberculosisSeragon P1 Active ARN-810 estrogen receptor sm Oncology prostate cancer etc

Seres P2 Active SER109 C.difficile LBP infection Clostridium difficile infectionSginalChem Life ScienceDis Active TYRO3 sm OncologySginalChem Life ScienceDis Active AXL sm OncologySginalChem Life ScienceDis Active LRRK2 sm CNS PDSginalChem Life ScienceDis Active TTBK1 (tau-tubulin kinase 1) sm CNS ADSginalChem Life ScienceP1 Active SLC-0111 Carbonic anhydrase 9 sm Oncology

Shenogen P2 Active icaritin estrogen receptor alpha 36 sm Oncology HCCShire Market Active iduronate-2-sulfat Elaprase iduronate-2-sulfatase enzyme Hunter syndrome (MPS-II)

SignalRx P1 Active SF1126 PI3K sm Oncology CLLSilence Therapeutics P1 Active Atu027 PKN3 NAT Oncology

Sirtris P2 Active SRT2104 sirt1 sm Diabetes T2DMSmith & Nephew Market Active Supartz

Sorbent P1 Active CLP-1004 potassium channel sm Nephrology CKDSpark P3 Active RPE65 RPE65 gene gene therapy Rare disease inherited retinal dystrophies

Spectrum Market Active ibritumomab tiuxeZevalin CD-20 mAb Oncology NHLSpectrum P3 Active ibritumomab tiuxeAevalin CD-20 mAb Oncology diffuse large B-cell lymphoma

Spinfex pharma P2 Active EMA401 angiotensin II type 2 (AT2) receptorsm CNS neuropathic pain (postherpatic etc)Stem Cell TherapeuticsDis Active CD-200 mAb OncologyStem Cell TherapeuticsPC Active CD-47 mAb Oncology AML

Stemline P2 Active SL-401 IL-3 conjugated diphtheria toxin IL-3 biologics Oncology hematological malignanciesSum Pharma P3 Active MK-3222 tildrakizumab Merck IL-23 mAb AIID psoriasis

Summit P1 Active SMT C1100 utrophin sm Rare disease DMD

Summit P2 Active SMT 19969 C. dificile sm Infection C. dificileSunovion P2 Active DSP-8658 PPAR alpha/gamma sm CNS AD

SuppreMol P2 Active SM101 soluble Rc receptor Fc fusion proteAIID ITP, SLE, RA etcSuppreMol PC Active SM201 FcgammaRIIB mAb AIID

Sutro Biopharma ActiveSyndax P3 Active entinostat Eddingpharm HDAC sm Oncology breast, lung and other solid tumor

SynDevRx PC Active SDX-7175 MetAP2 sm OncologySynta P3 Active STA-9090 ganetespib hsp90 sm Oncology NSCLC

Tacere ActiveTaigen P1 Active TG-0054 burifaxor CXCR4 sm Oncology various cancers, stem cell mobilizer etcTaigen P2 Active TG-2349 HCV protease sm Infection HCVTaigen Registration Active nemonoxacin quinolone sm Infection broad spectrum quinoloneTaisho P1 Active TS-071 luseogliflozin SGLT2 sm Diabetes T2DMTaisho P3 Active luseogliflozin SGLT2 sm Diabetes T2DM

Taiwan Liposome CompanyP2 Active lipotecan HIF 1 alpha, TOP1, sonic hedgehog sm Oncology HCCTakeda P1 Terminated TAK-357 CNS ADTakeda P1 Terminated TAK-591 CVS hypertensionTakeda P1 Terminated MLN0518 Oncology GlioblastomaTakeda P1 Terminated TAK-259 Oncology Overactive bladderTakeda P1 Terminated TAK-441 Oncology solid tumorsTakeda P1 Terminated TAK-448 Oncology prostate cancerTakeda P1 Terminated TAK-701 Oncology Advanced malignancies