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Writing Stellar NIH BiosketchesCrystal Botham, PhD
Director, Grant Writing Academy (https://grantwriting.stanford.edu)
Director, Research Development (Dept. Pediatrics)
https://grants.nih.gov/grants/forms/biosketch.htm
Example: Morgan Casey Hunt
Info Table at top of pageA. Personal StatementB. Position and HonorsC. Contributions to ScienceD. Additional Information: Research Support or Scholastic
Performance (generally only for NRSA Fellowships)
What is the NIH Biosketch used for?
What is the NIH Biosketch used for?
https://med.stanford.edu/mchri/funding_opportunities/postdoctoral-support.htmlPostdoc Support Policy
4. Investigators. Are the investigators appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers? Does the investigative team bring complementary and integrated expertise to the project (if applicable)?
Important Instructions!
• NIH Biosketch may not exceed 5 pages• Figures, tables (other than those included in the provided format
page), or graphics are not allowed in the biosketch. Do not embed or attach files (e.g. video, graphics, sound, data)
C. Contributions to Science – Let’s start here!
• Describe up to five of your most significant contributions to science. • Each contribution should be no longer than one half page, including citations
• Provide a URL to a full list of your published work. • Must be to a Federal Government website (a .gov suffix)• NIH recommends using My Bibliography
C. Contributions to Science – Content
For each contribution, indicate the following:• the historical background that frames the scientific problem• the central finding(s)• the influence of the finding(s) on the progress of science or the application of
those finding(s) to health or technology• your specific role in the described work
***
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*** Very important but most early drafts don’t have this!
Highly recommend this video:
• Transform your Writing with Elements of Scientific Storytelling -Jennifer Stonaker, PhD
• https://grantwriting.stanford.edu/secured/elements-of-scientific-storytelling/
The Story Arc
What is the topic?
What motivated the research?
What did you do?
Why was it significant?
How has the research transformed your field?
1. Improved cardiac donor evaluation and management. My early work in the field of heart transplantation focused on the evaluation of suitable donor hearts for transplantation. Currently, there are no standardized national guidelines for donor heart suitability for transplant, which has caused great variability in donor heart acceptance across the United States. The lack of guidelines on donor heart acceptance directly results from a paucity of high-quality evidence-based data on donor heart selection. This unmet need motivated me to collaborate with local organ procurement organizations to establish an organ donor research database that I used to systematically study the tools currently used for cardiac donor evaluation (electrocardiograms, echocardiograms, serum troponin levels), and to define the relationship between donor beta-receptor polymorphisms and cardiac function. The data and recommendations resulting from this work, funded by an NIH/NHLBI K23 Career Development Award, are now being used by organ procurement organizations across the United States to improve cardiac donor evaluation and management.
Look at an example: Dr. Kiran Khush
1. Improved cardiac donor evaluation and management. My early work in the field of heart transplantation focused on the evaluation of suitable donor hearts for transplantation. Currently, there are no standardized national guidelines for donor heart suitability for transplant, which has caused great variability in donor heart acceptance across the United States. The lack of guidelines on donor heart acceptance directly results from a paucity of high-quality evidence-based data on donor heart selection. This unmet need motivated me to collaborate with local organ procurement organizations to establish an organ donor research database that I used to systematically study the tools currently used for cardiac donor evaluation (electrocardiograms, echocardiograms, serum troponin levels), and to define the relationship between donor beta-receptor polymorphisms and cardiac function. The data and recommendations resulting from this work, funded by an NIH/NHLBI K23 Career Development Award, are now being used by organ procurement organizations across the United States to improve cardiac donor evaluation and management.
Look at an example: Dr. Kiran Khush
What is the topic?
What motivated the research?
What did she do?
Why was it significant?
How has the research transformed your field?
Break Down or Write A ContributionWhat is the topic?
What motivated the research?
What did you do?
Why was it significant?
How has the research transformed your field?
Each Contribution -- Cite up to four publications or research products• Not published yet ? - you may mention manuscripts that have not yet been
accepted for publication as part of your contribution, but you may cite onlypublished papers to support each contribution
• Research Products include: • Interim research products (https://grants.nih.gov/grants/interim_product_faqs.htm)• Audio or video products• Conference proceedings such as meeting abstracts, posters, or other presentations• Patents• Data and research materials• Databases• Educational aids or curricula• Instruments or equipment• Models• Protocols• Software or netware
C. Contributions to Science
B. Positions and Honors
Positions and Employment 1998-2000 Fellow, Division of Intramural Research, National Institute of Drug Abuse, Bethesda, MD
2000-2002 Lecturer, Department of Psychology, Middlebury College, Middlebury, VT
2001- Consultant, Coastal Psychological Services, San Francisco, CA
2002-2005 Assistant Professor, Department of Psychology, Washington University, St. Louis, MO
2007- Associate Professor, Department of Psychology, Washington University, St. Louis, MO
Other Experience and Professional Memberships 1995- Member, American Psychological Association
1998- Member, Gerontological Society of America
1998- Member, American Geriatrics Society
2000- Associate Editor, Psychology and Aging
2003- Board of Advisors, Senior Services of Eastern Missouri
2003-05 NIH Peer Review Committee: Psychobiology of Aging, ad hoc reviewer
2007-11 NIH Risk, Adult Addictions Study Section, members
Honors 2003 Outstanding Young Faculty Award, Washington University, St. Louis, MO
2004 Excellence in Teaching, Washington University, St. Louis, MO
2009 Award for Best in Interdisciplinary Ethnography, International Ethnographic Society
C. Contribution to Science 1. My early publications directly addressed the fact that substance abuse is often overlooked in older adults.
However, because many older adults were raised during an era of increased drug and alcohol use, there
are reasons to believe that this will become an increasing issue as the population ages. These
publications found that older adults appear in a variety of primary care settings or seek mental health
providers to deal with emerging addiction problems. These publications document this emerging problem
but guide primary care providers and geriatric mental health providers to recognize symptoms, assess the
nature of the problem and apply the necessary interventions. By providing evidence and simple clinical
approaches, this body of work has changed the standards of care for addicted older adults and will
continue to provide assistance in relevant medical settings well into the future. I served as the primary
investigator or co-investigator in all of these studies.
a. Gryczynski, J., Shaft, B.M., Merryle, R., & Hunt, M.C. (2002). Community based participatory
research with late-life addicts. American Journal of Alcohol and Drug Abuse, 15(3), 222-238.
b. Shaft, B.M., Hunt, M.C., Merryle, R., & Venturi, R. (2003). Policy implications of genetic
transmission of alcohol and drug abuse in female nonusers. International Journal of Drug Policy,
30(5), 46-58.
c. Hunt, M.C., Marks, A.E., Shaft, B.M., Merryle, R., & Jensen, J.L. (2004). Early-life family and
community characteristics and late-life substance abuse. Journal of Applied Gerontology, 28(2),26-
37.
d. Hunt, M.C., Marks, A.E., Venturi, R., Crenshaw, W. & Ratonian, A. (2007). Community-based
intervention strategies for reducing alcohol and drug abuse in the elderly. Addiction, 104(9), 1436-
1606. PMCID: PMC9000292
2. In addition to the contributions described above, with a team of collaborators, I directly documented the
effectiveness of various intervention models for older substance abusers and demonstrated the importance
of social support networks. These studies emphasized contextual factors in the etiology and maintenance
of addictive disorders and the disruptive potential of networks in substance abuse treatment. This body of
work also discusses the prevalence of alcohol, amphetamine, and opioid abuse in older adults and how
networking approaches can be used to mitigate the effects of these disorders.
a. Hunt, M.C., Merryle, R. & Jensen, J.L. (2005). The effect of social support networks on morbidity
among elderly substance abusers. Journal of the American Geriatrics Society, 57(4), 15-23.
b. Hunt, M.C., Pour, B., Marks, A.E., Merryle, R. & Jensen, J.L. (2005). Aging out of methadone
treatment. American Journal of Alcohol and Drug Abuse, 15(6), 134-149.
A. Personal Statementwrite last, specific for each proposal
• Describe why you are well-suited for your role(s) in this project• Relevant factors include: aspects of your training; your previous experimental
work on this specific topic or related topics; your technical expertise; your collaborators or scientific environment; and/or your past performance in this or related fields
• You may cite up to four publications or research products that highlight your experience and qualifications for this project
A. Personal Statementwrite last, specific for each proposal
• State long-term research career goals -> focus on maternal & child-health• Describe prior training, including expertise gained and research creativity• Cite awards, fellowships, etc.• Highlight current research• Explain that this award will enable new skills / experiences needed for
next career stage
A. Personal Statement
A. Personal StatementThe goal of the proposed work is to examine sex differences that arise during placental development and understand how these sex differences place male fetuses at greater risk for complications of pregnancy. My core motivation is to understand how biological sex manifests at the level of cells, tissues, and organisms to create different healthy baselines and disease risks for males and females.
As a graduate student with Dr. Theo Palmer, I studied brain development, corticogenesis, embryology, placental biology, and reproductive immunology using a mouse model of maternal immune activation, and I became inspired to study sex differences within that model through interaction with my committee member and mentor Dr. Marcia Stefanick. In my thesis work (Braun et al., 2019 under review), I demonstrated that placental dysfunction caused by maternal inflammation impacts fetal brain development differently in males and females. This discovery was the impetus for my submitted first author paper, in which I track the timeline of developmental disruption following maternal inflammation in order to understand where and when male and female trajectories diverge. In this work I outline a conceptual framework for how sex differences in response to an acute environmental insult can be propagated across the fetal-maternal interface to the developing brain, producing divergent neuroanatomical and behavioral effects that persist to adulthood.
Over the course of my PhD I became increasingly drawn toward translational work. To make the transition from basic research in mouse to clinical research in human, I initiated a collaboration with Dr. Virginia Winn, now my postdoctoral mentor, to compare mouse and human placental transcription and to examine sex differences in gene expression at the critical early stages of placentation. Dr. Winn’s expertise and enthusiasm in the realm of human placental biology has encouraged me to look more closely at placental function as a crucial mediator of fetal and postnatal health, and as a precipitating factor for pregnancy complications and future maternal disease risk. I have brought my own expertise in prenatal sex differences to the lab, adding a new dimension to Dr. Winn’s exciting work.
Throughout my career, I will continue to lead research efforts to understand how biological sex – along with the parallel societal variable of gender – affects human health from gestation to adulthood. I am a vocal advocate for the inclusion of both sexes in animal and cell-based research, and have spoken to undergraduates, graduate students, medical students, basic researchers, clinicians, and members of the public about the distinction between sex and gender, providing guidelines for the critical examination of both variables in the context of experimental and epidemiological data, as well as in everyday life.
Thank you, Amy Braun, for sharing.
Info Table at top of page
B. Position and Honors
• List in chronological order (old to newest) to the positions you've held that are relevant to this application, concluding with your present position
• List any relevant academic and professional achievements and honors. In particular: Students, postdoctorates, and junior faculty should include scholarships, traineeships, fellowships, and development awards, as applicable
• Clinicians should include information on any clinical licensures and specialty board certifications that they have achieved
B. Position and Honors
D. Research Support
• List ongoing and completed research projects from the past three years that you want to draw attention to
• Briefly indicate the overall goals of the projects and your responsibilities
• Do not include the number of person months or direct costs.
D. Research Support
Questions?
https://grants.nih.gov/grants/how-to-apply-application-guide/forms-e/general/g.240-r&r-seniorkey-person-profile-(expanded)-form.htm#Instructions
Stanford Maternal and Child Health Research Institute
MCHRI Funding OverviewJanuary 9, 2020
mchri.stanford.edu
MCHRI Resources
Funding Opportunities
Seed Grants
Bridge
Training
Faculty Scholars
Donor Directed
Research Operations
Clinical Research Support Office
Regulatory Support
Research Coordinator Services
Study Consultation
Biostatistics & Data Management
Educational Programs
Research Seminars
Annual Symposium
Informational Workshops
Translational Medicine Courses
MCHRI Funding Opportunities
Program Deadlines Award EligibilityPilot Grants Apr. 1, Oct. 1 $35K Instructors & Above
Clinician Educator Apr. 1, Oct. 1 $35K Clinical Instructors & Above
Transdisciplinary Initiatives
LOI: Jan. 15Proposal: Apr. 8 $100K / Yr. (2 yrs.) 2 Faculty with Primary Appointments in
Different Schools
Bridge Funding Jan. 15, May 15 $100K (50/50 split with awardee’s dept.) Assistant Professors & Above
Clinical (MD) Trainee Feb. 3 Up to 100% Salary/Fringe
for 2yrs. Clinical (MD) Fellows
Master’s Tuition Feb. 3 Up to $30K / Yr. (2 yrs) Clinical (MD) Fellows, Instructors & Assistant Professors
Postdoctoralsupport Mar. 2, Sep. 1 Up to 100%
Salary/Benefits (1.5 yrs) Postdoctoral Fellows (PhD)
K-support for instructors See website $50K for 2 yrs. (50/50 split
with awardee’s dept.) Instructor on K-award
Faculty Scholars LOI: Mar. 11Proposal: Jun. 1 $100K / Yr. (3-5 yrs.) Assistant & Associate Professors
22q11 Neuropsychiatric
LOI: Aug. 15Proposal: Sep. 23 Up to $150,000 / Yr. (2 yrs) All Stanford Faculty; multi-PI approach
recommended
Seed
Gra
nts
Trai
nees
Br
idge
Fa
culty
Sc
hola
rs
Donor Directed
MCHRI Funding Program Chairs
CLINICAL TRAINEE CLINICIAN EDUCATOR
FACULTY SCHOLARS
PILOT
Paul Grimm Jeff FeinsteinKathy SakamotoGary Shaw Julien Sage Hsi-Yang Wu
Gerald Grant
Daniel Bernstein
Bert Glader
Deirdre Lyell
Harvey Cohen
David K. Stevenson
BRIDGE FUNDING
Anthony Oro
POSTDOCTORAL SUPPORT
Well-established, rigorous review process, merit-based scientific review by experienced investigators.
Postdoctoral Support (March 2, 2020)
Goal: “Provide salary support to postdoctoral fellows focused on maternal and child health research.”
Eligibility: Postdoctoral fellowsFunding: Up to $80,000/yr, 2 years*
• Strong mentoring plan required• Eligibility is limited to first through third year postdoctoral fellows• All applicants must have a postdoctoral appointment date effective no later than the
application deadline• Requires application to external funding before end of 2nd year ** Competitive & External to Stanford
• Non-MCHRI funding, internal or external, takes precedence• Research mentor to provide non-salary research support
Always contact MCHRI Administration for policy questions or interpretation
Clinical Trainee Support (February 3, 2020)
Goal: “Provide support and create a pathway for training the next generation of physician and biomedical scientists focused on maternal and child health.”
Eligibility: Clinical fellows (or resident as appropriate within the discipline)
Funding: Up to 100% salary + benefits for 2 years
• Strong mentoring plan required• Supports 2nd and 3rd years of fellowship• Requires application to external funding before end of 2nd year• Non-MCHRI funding, internal or external, takes precedence• Research mentor to provide non-salary research support• External salary from competitive grant qualifies for one-time non-salary incentive• New Palliative Care Research fellowship, $75K per year for 2 years
Always contact MCHRI Administration for policy questions or interpretation
* Competitive & External to Stanford
Clinical Trainee and Postdoctoral Support
Supporting Documentsa. Applicant Information
i. NIH Biosketch (max 5 pages)ii. Personal Statement. Focus on career plans and how this award would help
you achieve your goals (max 0.5 page) * Clinical Trainee only
iii. Division Chief or Department Chair Nomination Letter (including attestation of 75% protected research time *Clinical Trainee Only
iv. Documentation of Competitive External Funding Application- requirement for renewal
b. Primary Research Mentor Informationi. NIH Biosketch (max 5 pages)ii. Completed online mentor support formiii. Letter attesting to salary cost sharing for year 2 of funding (must state
amount) *Postdoc Only
Clinical Trainee and Postdoctoral Support
Supporting Documents (continued)
c. Non-Primary Mentor Informationi. Letters of Support
ii. NIH Biosketch (max 5 pages per person)
d. Co-Investigator Informationi. Letters of Support
ii. NIH Biosketch (max 5 pages per person)
e. IRB Approval (if applicable)
Review Criteria
Overall Evaluation Description
High Exceptionally strong with only one or a few minor weaknesses
Medium-High Strong but with several minor weaknesses
Medium-Low Some strengths but with at least one major weakness
Low Few strengths and several major weaknesses
Definitions
Minor Weakness: easily addressable, does not lessen impact
Major Weakness: requires major change, significantly limits
impact
• NIH criteria: significance, approach, innovation, investigator, environment, training value
• Three reviewers per proposal• All applicants receive written
comments, no score• Offer 1:1 with reviewer before each
cycle (sign-up). Primary research mentor must review prior.
Postdoctoral Support Funding Rates
Year Applications Awards % Funded $ Awarded
FY19 111 18 16% $1,273,411
FY18 93 14 15% $897,392
FY17 64 18 28% $947,000
FY16 64 24 38% $1,129,000
FY15 72 20 26% $1,000,000
Clinical Trainee Support Funding Rates
Year Applications Awards % Funded $ Awarded
FY19 27 17 63% $1,582,482
FY18 31 20 64% $2,055,649
FY17 18 9 50% $1,564,398
FY16 18 10 55% $953,000
FY15 19 12 63% $910,500
Tips for Success
• Relevance to Maternal and Child Health• Write clearly• Signs of Strong Mentorship• Have a Strong Statistical Plan (QSU)• Propose Realistic Timeline
• Enrollment goal• Avoid Over Ambitious Project• Avoid too Many or Interdependent Aims
• Include Collaborator with Key Expertise (LOS)• Propose Work that is Original or New
FY19 Funding by Rank ($7.9M)
16%
24%38%
22% PhD Postdocs
MD Fellows
Junior Faculty
Mid-Senior Faculty
78% early career investigators
Biostatistics & Data Management Support
Eligibility: available to all MCHRI members and their mentees at no cost for research projects directly related to maternal and child health
§ Quantitative Sciences Unit (QSU) Partnership• Comprehensive biostatistics and data management support.• Research directly related to maternal and child health. • Over 30+ data scientists faculty, masters, and PhD level staff.• Expertise in study design, database creation, data management, and data
analysis using interdisciplinary collaborative approach.• Fill out a “QSU Project Initiation Form” at http://med.stanford.edu/qsu• Meet with QSU at least 4-weeks prior to deadline.• QSU Office Hours
MCHRI Clinical Research Support Office
• Enabling innovative, high-quality research is critical to fulfilling the mission of SCH. The Clinical Research Support Office
§ Provides operational, informatics, regulatory, and other support for execution of studies at SCH.
§ Addresses critical challenges in research infrastructure § Develops solutions to enhance research collaboration between SoM and SCH § Serves as a resource for physician, nurse, and allied health researchers§ Liaises with all hospital departments to enable efficient and compliant conduct
of clinical research
Research Coordinator Support (fee for service)
• Administer questionnaire• Answer queries• Billing oversight• Budget consultation/preparation• Complete/Create case report forms• Conduct patient visits• Consent form preparation• Consent Patient• Database development• Data collection/reports/entry• Drug accountability/ordering• Enrollment• IND/IDE submission• In-service staff• Investigator/site initiation meeting
• IRB submission/renewal/modification• Monitor visits/e-monitoring• Prepare visit documents• Patient reimbursement• Patient screening• Patient visits (LPCH, SHC, CTRU)• Record storage• Recruitment effort & tools• Report adverse events• Pharmacy Set-up• Schedule visits• Specimen handling & shipping• Study closeout• Supplies management
May ZepedaClinical Research Manager
October 7, 2019Efficient and Scalable Analysis of the Clinical Genome as a Foundation for Precision MedicineGill Bejerano, PhD, Jon Bernstein, MD, PhD
December 2, 2019Intergenerational Transmission of Risk for PsychopathologyIan Gotlib, PhDLucy King, PhD Student
January 13, 2020Improving School Readiness; A Randomized Controlled Trial Lisa Chamberlain, MD
February 3, 2020Ways to Prevent, Diagnose, and Treat Children with Food AllergiesKari Nadeau, MD, PhDHoward Chang, MD, PhD
March 2, 2020Systems Medicine in Pediatric DiseaseDennis Wall, PhD 2nd Speaker TBD
April 6, 2020Clinical Research Support Office (CRSO) Karl Sylvester, MDAlyson Falwell, MPH
May 4, 2020Topic in Advancing Maternal Health Speaker TBD
June 1, 2020Topics in Pediatrics & Genomics Mike Snyder, MD, FACS2nd Speaker TBD
FY20 SEMINAR SERIES
Website
Postdoctoral Support Program Page
Clinical Trainee (MD) Support Program Page
Frequently Asked Questions (FAQ)
10-year FactBook
Annual Report
May ZepedaAlyson Falwell Sijo Thomas
Questions?
LPCH Clinical Research Operations Manager
LPCH Clinical Research Informatics Manager
Clinical Research Manager
Kim Stern
[email protected]@stanford.edu
Assoc. Program Manager
