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William Harvey Day Programme 2010
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William Harvey Day ProgrammeTuesday 26 October 2010St Bartholomew’s Hospital, West Smithfield, London
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Welcome to William Harvey Day
William Harvey Day will showcase some of the bestcutting edge research currently underway in Barts andthe London, School of Medicine and Dentistry and in ourpartner NHS Trusts. There will be nine presentations bySchool researchers, as well as three science “hot topics”presented by leading researchers who have recentlyjoined the School, and three guest lectures.
We are delighted that these will be given by Sir Tim Hunt FRS, NobelLaureate and principal researcher at the Cancer Research UK Clare HallLaboratories, Professor Sir Mark Walport, Director of the Wellcome Trust and Professor Marcus du Sautoy, Professor for the Public Understanding of Science and Professor of Mathematics at the University of Oxford.
The day will conclude with the Barts and The London NHS Trust’s traditionalannual St Luke’s-tide Service in the church of St Bartholomew the Great. I would be delighted if you were able to attend the Service, as this is atraditional and very enjoyable part of the day.
Professor Sir Nicholas WrightWarden, Barts and The London, School of Medicine and Dentistry
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Venue information
The Great Hall and PathologyMuseumThe event registration desk is located just insidethe main entrance to the Great Hall and acloakroom is also available here. Coffee and Lunchwill be served in two separate venues; the GreatHall and the Pathology Museum (located in thePathology Building). Posters will also be displayedin both venues. To ensure you can view all postersand prevent overcrowding in each venue, the frontof this programme indicates which venue youshould attend for the morning coffee break andlunch.
Robin Brook CentreAll lectures and oral presentations will be takingplace in the Morris Lecture Theatre which issituated in the Robin Brook Centre. Please notethat once the lecture theatre is full, you will bedirected to either the Patterson Ross or BainbridgeRoom where the sessions can be watched on abig-screen.
St. Bartholomew the GreatThe St. Luke’s-tide service will take place in thechurch of St Bartholomew the Great at 6.00pmwhich is located 2 minutes walk from StBartholomew’s Hospital. If you are joining theacademic procession, your gown will be availablein the Great Hall from 5.00pm onwards.
The Butchers’ HallIf you have booked to attend the subscriptiondinner, this will take place at the Butchers’ Hall, 87Bartholomew Close. This is around 2 minutes walkfrom the hospital and is shown on the map at therear of this programme.
CPD ApprovalWilliam Harvey Day is accredited for CPD. In orderto claim the credits, you will need to sign the CPDregister in the foyer area of the Great Hall.Certificates will be available at the end of the day.
04 Queen Mary, University of London
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8:30Registration (Great Hall entrance foyer)
Coffee/Tea and poster display (Great Hall)
Posters will be in the Great Hall and PathologyMuseum for viewing throughout the Day
8:50Welcome and Introduction – Professor SirNicholas Wright, Warden, Barts and The LondonSchool of Medicine and Dentistry
Session 1 – chaired byProfessor Graham Hitman08:55Hot Topic in Science‘Flip-flops are best when paddling in Bile’
Professor Kenny Linton, Blizard Institute of Celland Molecular Science
9:10Oral presentations
‘Use of preclinical FDG-PET to predict outcomein response to anti-angiogenic therapy in twomouse models of metastatic cancer’Julie Foster, Institute of Cancer
‘Breakage of B cell tolerance by antigens onfollicular dendritic cells’Mohey El Shikh, William Harvey Research Institute
‘Mutations in C16orf57 and normal lengthtelomeres unify a subset of patients withdyskeratosis congenita, poikiloderma withneutropenia and Rothmund-Thomson syndrome’Amanda Walne, Blizard Institute of Cell andMolecular Science
09:55Year 1 Medical Student Research ProjectPrizewinner
‘The present and future of osteoarthritis’Rafae Shaikh
10:05Sir Anthony Dawson Lecture
‘How to avoid futile cycles: A new element in thecontrol of mitosis’Sir Tim Hunt FRSNobel Laureate 2001, CRUK Laboratories(Introduced by Professor Sir Nicholas Wright)
10:50Coffee and poster viewing (Great Hall & PathologyMuseum)Please refer to the front of this programme whichindicates which venue you should attend.
Session 2 – chaired byProfessor Mike Curtis11:20Hot Topic in Science
‘Unraveling the transport requirements of cargowaiting to leave the endoplasmic reticulum’Professor Carol Shoulders , William HarveyResearch Institute
11:35Oral presentations
‘The role of the receptor tyrosine kinase Axl inintercellular adhesion and signalling incutaneous squamous cell carcinoma’Monika Cichon, Blizard Institute of Cell andMolecular Science
Programme
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06 Queen Mary, University of London
Programme (cont)
‘Effect of folic acid on cognitive decline: meat analysis of randomised trials’Mark Simmonds, Wolfson Institute
‘The use of “Cell Sheet” technique enhances thetherapeutic effects of skeletal myoblasttransplantation with elimination ofarrhythmogenicity’Takuya Narita, William Harvey Research Institute
12:20Year 1 Medical Student Research ProjectPrizewinner
‘Anti-Platelet Treatment in Non-ST-Elevated-Myocardial Infarction’Nadia Taylor
12:30William Harvey Lecture
‘A century of inborn errors in metabolism: FromGarrod to genomics’Professor Sir Mark Walport, Director, Wellcome Trust(introduced by Professor Rod Flower)
13:15-14:30Lunch and poster viewing (Great Hall andPathology Museum)Please refer to the front of this programme whichindicates which venue you should attend for lunch.
13:15Alumni Association AGM and Lunch (PeggyTurner Room)
Session 3 - chaired byProfessor Nick Lemoine14:30Hot Topic in Science
‘Evaluating tests in the absence of gold standard’Professor Khalid Khan, Institute of HealthSciences Education
14:45Oral presentations
‘Macrophage ablation retards progression of anaggressive mouse Lymphoma’Simon Hallam, Institute of Cancer
‘Management of Cardiovascular multimorbidity’Sally Hull and Rohini Mathur, Institute of HealthSciences Education
‘Dengue virus replicon inhibits responses toLipopolysaccharide: Insight into a novel functionfor Stat2?’William Alazawi, Blizard Institute of Cell andMolecular Science
15:30Schorstein Lecture
‘The Secret Mathematicians’Professor Marcus du Sautoy, Charles SimonyiProfessor for the Public Understanding of Scienceand Professor of Mathematics, University of Oxford(introduced by Professor Mike Curtis)
16:20Prize giving for oral presentations and posters.Professor Sir Nicholas Wright
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16:30The vision for the School of Medicine and DentistryProfessor Sir Nicholas Wright
16:40Afternoon Tea and Refreshments (Great Hall)
Academics joining the procession to StBartholomew the Great are requested to collecttheir pre-booked robes from the Great Hall by 17.30.
17:50 Academic procession leaves the North Wing
18:00 St Luke’s Tide Service (St. Bartholomew the Great)
The address will be given by the Rev’d ProfessorBernard Silverman FRS, Chief Scientific Advisor tothe Home Office, and the lessons will be read byProfessor Sir Nicholas Wright, Warden, and DrSteve Ryan, Medical Director, Barts and TheLondon NHS Trust.
19.15Pre-Dinner drinks reception (Butchers’ Hall)
19:45Dinner (Butchers’ Hall)
Grace will be said by Rev'd Professor NickGoulding.
After dinner speech by the Warden, Professor SirNicholas Wright, and a response on behalf of theguests.
The School is very grateful to the Barts and theLondon Charity for their support for the day.
Our thanks to Fulvio D’Acquisto and David Bulmerwho have very kindly agreed to judge the oralpresentations, and Patsy Munroe, Andy Stagg,Matthias Dittmar and Pedro Cutillas who arejudges for the poster display.
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Poster Presentations – Great Hall
08 Queen Mary, University of London
All posters will be displayed in the Great Hall andPathology Museum from 8.30am until 2.30pm.
Barts and The London NHS Trust1Contrast Enhanced Aortic DuplexUltraSonography Scanning (CEADUSS).Mr Shiva Dindyal
2Outcomes of a pilot roup using Mindfulness-BasedCognitive Therapy (MBCT) for people living withHIV and recurrent depression.Samantha Leaity
3Electronic Cytotoxic chemotherapy prescribingreduces prescription errors and improves cancerpatient safety.Dr Fiona McCarthy
4Who believes in oral HIV point of care tests? Asummary of 3 years experience and more than2000 OraQuick rapid tests.Nigel Garrett
5A new, highly efficient Aspergillus-specific PCR;DNA detection from histological material andbroncho-alveolar lavage fluid of infected patients.Gemma Johnson
6Can Apparent Diffusion Coefficient (ADC) PredictTumour Grade in Endometrial Carcinoma (EC)?Dr Nishat Bharwani
7An interpretative phenomenological analysis of thepsychosocial impact of HIV-drug resistance in agroup of gay men.Dr Dimitri Spiliotis
8Diffusion Weighted MR Imaging in the Detection ofPancreatic Neuroendocrine Tumours.Dr Chirag Patel
9Accuracy of main-stream end-tidal carbon dioxidemeasurement during stabilisation and roadtransport of mechanically-ventilated preterminfants with respiratory distress syndrome in thefirst 48 hours of life.Adel Abdelhamid
10Occult hyperfibrinolysis in trauma - a hidden killer.Imran Raza
11Evaluation of acute rehabilitation needs forpatients with traumatic injuries.Mrs Karen Hoffman
12Trauma associated cardiac injury and dysfunction.Henry De'Ath
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The Blizard Institute of Celland Molecular Science13Exome sequencing identifies thousands of novelcandidate mutations in coeliac disease.Vanisha Mistry
14Avoidance of vitamin D deficiency in pregnancy:the case for a unified approach in National policy.Barbara Boucher
15Promoting the survival, migration and integrationof Schwann cells after transplantation into spinalcord by overexpression of polysialic acid.Juan Luo
16A ChIP-seq defined genome-wide map of vitaminD receptor binding: associations with disease andevolution.Sreeram Ramagopalan
17Flow cytometric functional assays.Gary Warnes
18The putative cannabinoid receptor GPR55 definesa novel autocrine loop in cancer cell proliferation.Roberto Pineiro Cid
19Development of a easy to use Super-ResolutionLight Microscopy method for visualising biologicalstructures at 50nm resolution and below.Dr A Wheeler
20A study of psychophysiological responses tovisceral & somatic pain in functional chest pain – acase control study.Adam Farmer21Loss of type VII collagen in SCC increases cellinvasion through TGF-beta signalling.Vera Martins
22Class II phosphoinositide 3-kinase regulatesexocytosis of insulin granules in pancreatic betacells.Tania Maffucci
23Oesophageal epithelial ASIC3 is associated withincrease in severity of symptoms in patients withgastro-oesophageal reflux disease (GORD).Yang Chua
24Do Fas modified drug-loaded microspheres treat apaclitaxel resistant cell line?Nader Ibrahim
25Early growth response gene – 2 (Egr-2) is antumour suppressor gene.Tizong Miao
26Personal exposure to back carbon in East London.Miss Clare Ewin
27Frequent co-existence of constipation and faecalincontinence: a greatly underappreciated clinicalproblem.Sahar Mohammed
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Poster Presentations – Great Hall (cont)
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28IL-7 and T cell receptor signals coordinatelyregulate γδ cell pre-programming and lymph nodeIL-17 production.Dr John Pang
29Phenotyping visceral pain in humans usingfunctional brain imaging introduction.Steven Coen
30The effects of eicosapentaenoic acid delivered asdietary treatment after spinal cord injury.Jodie Hall
31Gender differences in brain activity evoked byvisceral pain in healthy subjects.Michiko Kano
32Analysis of the molecular mechanisms mediatingBmi1 function in satellite cells.Xinyu Zhang
33The clonal origins of dysplasia from intestinalmetaplasia in the human stomach.Dr Stuart McDonald
34Switching between two distinct cancer stem cellphenotypes in squamous cell carcinoma.Adrian Biddle
35Is there altered somatosensory processing ofnociception in a mouse model of multiplesclerosis.Saira Siddiqui
36Infliximab therapy alters antigen presenting cellpopulation dynamics in Crohn’s disease.Dr Neil McCarthy
37The PcG gene Bmi1 regulates satellite cellsfunction in young, aged and myopathic skeletalmuscles.Valentina Di Foggia
38Isolation and characterization of neural stem cellsfrom the postnatal cerebellum.Dario Ceric
39Barrett’s oesophagus glands are clonal, containmultiple stem cells, expand by fission and share acommon progenitor with the surroundingsquamous epithelium.Anna Nicholson
4020-HETE exhibits two phosphorylation-dependentactions on TRPV1.Hairuo Wen
41A novel and selective PDK1 inhibitor reducesbreast cancer cell invasion and tumour growth.Claudio Raimondi
42Investigation of mechanisms regulatingPI3K/p110γ expression in pancreatic cancer.Richard Buus
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43The utility of T cell receptor-like antibodies to targetHBV infected cells: the first steps towardsindividualised therapies for the treatment ofchronic HBV infection.Li Li
44The uptake of microspheres by breast cancer cells:improved delivery of chemotherapeutic agents.Mustafa Kadam
45An in vitro study of the potential stromal role inbasal cell carcinoma development through theinvestigation of GLI1 expression in basal cellcarcinoma derived fibroblasts.Jane Elliott
46The oncoprotein GLI1 induces an irreversiblebasal-like phenotype that confers androgenindependence upon LNCaP prostate cancer cells.Sandeep Nadendla
47Interferon-alpha mediates restriction of humanimmunodeficiency virus type-1 replication inprimary human macrophages at an early post-entry stage of replication.Kelly Cheney
48Bmi1overexpression induces apoptotic death ofneural progenitors during embryonic neocortexdevelopment through downregulation of Survivin.Serena Acquati
49The effects of Omega-3 polyunsaturated fattyacids on cell survival after injury in vitro.Stacy Gladman
50Characterising the steroid enzymes forendogenous cortisol synthesis in primary humankeratinocytes.Adil Jaulim
51Neural Stem Cells as therapeutic targets inGerminal Matrix Haemorrhage.William Dawes
52Retinoic acid metabolising blocking agentsincrease differentiation in squamous cellcarcinoma with loss of type VII collagen.Malcolm Avari
53Critical role of NaV 1.9 in the activation of visceralsensory nerve fibres by bradykinin but notadenosine.David Bulmer
54Validation of a new method for the assessment ofvascular endothelial function.Santron Sathasivam
55Gene Expression Profile during Progression fromPremalignant to Cutaneous Squamous CellCarcinoma.Nikol Mladkova
56Morphometric analysis of the remyelinated sciaticnerve after injury in knock-out C/EBPδmice.Hasanein Al-Hasani
57DNA methylation across generations.Michelle Holland
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Poster Presentations – Great Hall (cont)
12 Queen Mary, University of London
58Quantifying remyelination using high field (9.4T)magnetic resonance imaging.Dr Shoaib Ugradar
59High-throughput sequencing-based DNAMethylomics.Guillermo Carbajosa
60Different abilities of motilin and the motilinreceptor agonist GSK962040 to facilitatecholinergic and nitrergic activity in human isolatedstomach.Dr John Broad
61Bactericidal activity release profiles generated instatic biofilms are heterogeneous amongstdifferent strains of Pseudomonas aeruginosa.Richard Waite
62In vitro modelling of Basal Cell Carcinoma revealsa novel PTCH1-GLI1 signalling axis that isindependent of SMOOTHENED in humankeratinocytes.Muhammad Rahman
63Modulation of adipose core clock componentexpression in genetic obesity by metformin.Paul Caton
64ABCA12: a regulator of LXR-βmediated ABCA1expression.Daniel Poon
65EGR2 regulates inflammatory plasticity of effectorT Cells.Meera Raymond
66iASPP involvement in DNA repair in melanoma.Valentina Senatore
67Urinary free light chain excretion in primaryprogressive multiple sclerosis.Dr Ruth Dobson
68Asymptomatic Non Chlamydial Non GonococcalUrethritis in men is associated with high sexual risktaking behaviours: Symptom based triage missesmen at high risk for sexually transmitted infections.John Saunders
69iASPP/p63 auto-regulatory feedback loop isessential for epithelial integrity and autophagy.Anissa Chikh
70Clinical Trial: Influence of bovine colostrum onintestinal permeability in healthy athletes afterheavy exercise.Tania Marchbank
71Fingolimod enhances markers of remyelination inrat telencephalon spheroid cell culture.Samuel Jackson
72Understanding the tumour-suppressing activity ofrapamycin in epidermis.Katherine Sully
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73Functional evidence for a protective effect againstHIV-1 and Mycobacterium tuberculosis (Mtb)infection from the Toll-Like Receptor (TLR)-8single nucleotide polymorphism (rs3764880).David van Bockel
74Factors within human inflamed intestinal mucosauncouple lymphocyte imprinting and regulatory Tcell generation by dendritic cells.Theo Sanders
75Organ specific autoantibodies in patients withadult onset diabetes.Mohammed Hawa
76Senescence in human Basal Cell Carcinoma.Muhammad Pirzado
77Trisomic dose of several chromosome 21 genesperturbs haematopoietic stem and progenitor celldifferentiation in Down Syndrome.Claudia Canzonetta
78A day at the mosque: finding culturally appropriateways to engage people in diabetes research by theNorth East London Diabetes Research Network.Gillian Hood
79Towards an understanding of the link between thelipid floppase ABCB4 and the lipid flippaseATP8B1 in the canalicular membrane of thehepatocyte.Michael Nicolaou
80Effects of the immuno-suppressive rapamycin onepidermis.Olufolake Akinduro
81Prospective randomized double-blind placebo-controlled crossover study of sacral nervestimulation in patients with severe rectalevacuatory dysfunction allied to rectalhyposensitivity.Mr Noel Thin
82Oxidative stress and senescence of balding dermalpapilla cells.Jamie Upton
83Early thymic T Cell Receptor signal initiation isindependent of receptor oligomerization.Joana Neves
84VZV replication and its association with keratin 15expression and Wnt signalling.Manuraj Singh
85Homeodomain transcription factors Pbx andPknox regulate location-specific epidermalbarriers via differential expression of LCE barriergenes.Stuart Brown
86The DSPII splice variant is critical for desmosome-mediated HaCaT keratinocyte adhesion.Dan Tattersall
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Poster Presentations – Great Hall (cont)
14 Queen Mary, University of London
87Phospholipase C signalling in cutaneoussquamous cell carcinoma.Emily Ruban
88Tissue damage activates an inflammatoryresponse in trauma.Joanna Manson
89Neutralisation activity in a geographically diverseEast London cohort of HIV-1 infected patients:Clade C infection results in a stronger and broaderhumoral immune response than clade B infection.Hanna Dreja
90Clonal evolution in Barrett’s oesopgagusdetermined by genetic diversity.Mr Shabuddin Khan
91Assessing the feasibility of a new method for thenon-invasive measurement of endothelial functionin conduit arteries.Miss Amandeep Mukal
92Induction of cellular senescence by miRNA co-operation?Cleo Bishop
93Monozygotic twins discordant for MS anddiscordant for serology disprove cytomegalovirusinfection implication in MS.Monica Calado Marta
94The tumour suppressor PTCH1 regulates EGFRsignalling in human keratinocytes: implications forthe treatment of basal cell carcinoma.Dimalee Herath
95A model of intrauterine hyperglycaemia providesevidence for fetal programming of glucosetolerance and a platform for epigenomic studies inmouse and human.Sarah Finer
96Identification of DNA methylation, histonemodifications and gene expression differences inMZ twins.Carolina Gemma
97Post entry restriction of MLV-B and MLV-NBcapsids in human cells is envelope dependent.Nidia Oliveira
98Identification of novel imprinted genes in humans.Lisa Nanty
99Using Next-Generation Sequencing to IdentifyNovel Disease Genes.Diana Blaydon
100Retinoic acid and aryl hydrocarbon receptorsignalling exert opposing effects on differentiationof human dendritic cells (DC) and their ablilty toimprint intestinal homing.Nichola Gellatly
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101Circulating ‘gut-tropic’ Vδ2 T-cells are altered inCrohn’s disease patients and their siblings.Charlotte Hedin
102Genetic dissection of trisomy 21 pathology usingtranschromosomic cellular modelling.Dean Nizetic
103Can an ex vivo human liver biopsy model be usedto test the efficacy of drugs for the treatment ofhepatitis C?Alia Javaid
104Quantitative-PCR analysis of Fusobacteriumnucleatum associated with adverse pregnancyoutcomes.Cecilia Gonzales-Marin
105Inherited predisposition of oesophageal diseases(IPOD): A Genome Wide Association Study ofBarrett’s Oesophagus.Laura Gay
106Nano-antigen presenting cells (Nano-APC) for thedevelopment of therapeutic vaccines.Mengya Liu
Institute of Health SciencesEducation107Adverse events and manual therapy: A systematicreview.Dawn Carnes
108Maternal Vitamin D Deficiency in Tower HamletsPCT.Ameana Khan
109Progress on progress testing: Barts and theLondon’s initial experience of the UK Multi-SchoolProgress Testing Project.Patricia Revest and John Patterson
110Prescribing for Chronic Obstructive PulmonaryDisorder in general practice: exploring healthinequalities by ethnicity, sex and age.Alice Martin
111How do student’s best learn anatomy? Exploringstudent’s responses to the resources available.Mohammed Bajalan
112What are the attitudes of young people from ethnicminorities towards mental illness in different areasof London?Maryam Zulafkar
113Knowledge and understanding of HIV, AIDS andSTD among adolescents in Hamburg, SouthAfrica.Dr Jeannette Naish
114Evaluation of a practice based intervention toreduce health inequalities in chronic diseasemanagement.Ellena Badrick
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Poster Presentations – Great Hall (cont)
115Back pain Reporting Outcomes Consensus(BaROC): a modified Delphi study.Robert Froud
116Collaborative working and UK NHS secondarycare for Chronic Obstructive Pulmonary Disease:impact of the UK National COPD Resources andOutcomes Project (NCROP) model of peer review.Carol Rivas
117Does prior exposure to clinical practice enhanceprocedural learning in simulation training?Rumman Ahmed
118Drug effectiveness at controlling type 2 diabetes by ethnicity and social deprivation.Gareth James
119An evaluation of the relationship between VitaminD status and quadriceps strength in patients withCOPD : a cross sectional study.Jonathan Fenn
120Identifying intimate partner violence in differentethnic groups in primary care.Alex Sohal
121Attendance and non-attendance at self-management courses.Dr Sharmin Shajahan
122Plagiarism: A study exploring the perceptions ofstudents and staff.Sinthuja Jeyarajah
123Carbon content of airway macrophages and lungfunction in children within the London lowemission zone (LEZ).Thomas Round
124Evaluating Doctors as teachers & educators –Does doing DATE as a student make a differenceto teaching practice after qualification?Faiz Anwar
125The representation of Government strategy andrisk concerning the swine flu vaccine in UKnewspapers during the pandemic period of April2009 to February 2010.Lakshmi Srikantharajah and Indarpreet Channa
126Investigating objective ways of measuring melaninlevels in order to study vitamin d status.Natasha Shrikrishna
127High-dose vitamin D3 during intensive phasetreatment of pulmonary tuberculosis: a double-blind randomised controlled trial.Adrian Martineau
Cancer Research UK128Whole colon field cancerisation in Crohn’silecolitis.Trevor Graham
16 Queen Mary, University of London
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129Stem Cell Niches in the Bladder? The ClonalOrganization of Human Urothelium.Nadine Gaisa
Institute of Cancer130FGF signalling and its implication in breast cancerdevelopment.Athina-Myrto Chioni
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Poster Presentations – Pathology Museum
Institute of Cancer1Shotgun identification of substrates of proteinkinase Akt1 by quantitative phosphoproteomics.Luisa Beltran
2Systematic analysis of genomic alterations inprostate cancer.Xueying Mao
3Genome wide study of DNA methylation in AML.Marwa Saied
4Analysis of the inflammatory profile of DCIS inrelation to altered myoepithelial cell phenotypeand disease progression.Michael Allen
5Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells.Nuria Coll Bastus
6Bone marrow failure in acute myeloid leukaemia isinduced by a block in differentiation of normalhematopoietic stem cells.Farideh Miraki-Moud
7Using a mouse model of Down’s Syndrome toidentify novel anti-angiogenic molecules.Marianne Baker
8An in vitro system to study the interaction betweenmacrophages and regulatory T cells.Juliana Candido
9SR-A promotes colitis induced colon carcinoma.Maud Bossard
10Towards targeting aVb6 in pancreatic cancer.Sabari Vallath
11Src inhibition in Renal Cell Carcinoma.Kevin Sharpe
12A non-replicating adenovirus expressing Hey1 iscytotoxic to prostate cancer cells.Katrina Sweeney
13Widespread epigenetic inactivation ofargininosuccinate synthetase renders lymphomassensitive to pegylated arginine deiminase.Barbara Delage
14Genetic profile of invasive breast cancervasculature.Dylan Jones
15The role of HAX1 in regulating avβ6-dependentcancer growth and invasion in vitro and in vivo.Chia-Yu Chen
16High-resolution genome-wide SNP analysissuggests a monoclonal origin of multiple prostatecancer foci.Lara Boyd
18 Queen Mary, University of London
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17S100PBP is ubiquitously expressed andmodulates the function of S100 calcium-bindingproteins in pancreatic cancer.Kate Lines
18The Pancreatic Expression database.Rosalind Cutts and Emanuela Gadaleta
19Investigation of the role of ZDHHC14 in humantumour development.Dr Marc Yeste Velasco
20Misbalance of Focal Adhesion Kinasephosphorylation enhances pathologicalangiogenesis.Tanguy Lechertier
21The chemokine receptor CXCR4 and malignanttransformation of the ovarian surface epithelium.Kyra Archibald
22In-depth characterization of the micro-RNAtranscriptome in Acute Myeloid Leukaemia withSolexa High-Throughput Clonal Sequencing.Silvana Debernardi
23Accumulation of 2hydroxyglutarate (2HG) inNormal Karyotype AML patients with IDH1mutation.Essam Ghazaly
24The effects of chemotherapy in combination withanti-IL-6 therapy on ovarian cancer cells.Vessela Vassileva
25Clonal selection of multiple TET2 mutations in thetransormation of chronic myelomonocyticleukemia to acute myeloid leukemia and itssubsequent relapse.Robert Petty
26An autocrine cytokine network in ovarian cancerthat influences patient survival.Hagen Kulbe
27AML1/ETO and the product of its target genePOU4F1 synergise to activate B- lineage geneexpression in t(8;21) AML.Jenny Dunne
28The Role of the Chemokine CXCL12 inExtracellular Matrix Remodelling in OvarianCarcinoma.Gemma Everitt
29Epigenetic regulation of miRNAs in Acute MyeloidLeukaemia.Floriana Manodoro
30Oncolytic vaccinia virus expressing decorin as anovel anti-cancer agent.Lynsey Whilding
31c-Met endosomal signalling and breast cancer cellmigration.Rachel Barrow
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Poster Presentations – Pathology Museum (cont)
32HER2 regulates αvβ6-dependent invasion ofbreast cancer cells.Dr Kate Moore
33DCIS-modified myoepithelial cells promoteangiogenesis: co-operation of avb6 integrin andFibronectin.Dr Sally Dreger
34Targeting CCR4 in epithelial tumours.Dr Moddasar Khan
35Phosphorylation patterns that correlate withchromosomal rearrangements in AML primarycells.Pedro Casado-Izquierdo
36Is C-Met expression associated with prognosticparameters in invasive breast cancer?Colan Ho-Yen
37Changes in the microenvironment of DCIS: therelationship between altered myoepithelial cellphenotype and inflammatory infiltrate.Khairiya Ahmed
38Identification of adenoviral E1A gene regionsnecessary for sensitisation to cytotoxic drugs inprostate cancer cells.Hector Maya
39Investigating the role of FGF signaling inpancreatic cancer.Stacey Coleman
40FGFR2b prevents premature skin ageing andtumourigenesis in mice.Maria Monterrubio-Acebes
41Macrophage scavenger receptor A promotestumor progression through increased B cellrecruitment.Eleni Maniati
42The role of c-Met in breast cancer drug resistance.James Hulit
43C-Met trafficking stimulates Rac1 in breast cancercells.Ludovic Menard
Institute of Dentistry44Novel role of desmoglein 3 in the regulation of E-cadherin adhesion through Src signalling.Mandy Tsang
45Two independent mechanisms regulate keratinK15 expression in keratinocytes: role of FOXM1.Amrita Bose
46Effect of demineralisation solutions circulationrates on hydroxyapatite dissolution kineticsstudied using scanning microradiography.Hanadi Lingawi
47Developing a porous material to use as a bonescaffold.Jonathan Hatton
20 Queen Mary, University of London
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48Sequential microtomographic measurements ofenamel demineralisation inhibited by statherin-likepeptides.Dr Paul Anderson
49Surgical excision of an epulis, case report.Drs Gillam, Besas and Chatzopoulou
50Determinants of nicotine dependence in UK-resident Yemeni khat chewers.Saba Kassim
51Measuring the interaction between statherin-likepeptide and hydroxyapatite using liquid cell atomicforce microscopy.Farah Ahmed
52Immortalization of Oral human keratinocytes withdefined genetic elements in the development oforganotypic oral culture.Saira Athar
53Effectiveness of fluoride foams in controlling dentalcaries in children.Dr Akash Jain
54The oral health and microbiota of UK Behçet’sdisease patients.Noha Seoudi
55The effect of omega-3 polyunsaturated fatty acidson normal and neoplastic oral keratinocyteapoptosis.Zacharoula Nikolakopoulou
56The candidate tumour suppressor HOPHomeobox (HOPX) is up regulated in humankeratinocytes independently of DNA strand breaksand senescence.Alice de Castro
57Immune responses to cytoskeletal proteins inBehçet’s disease patients.Mojgan Hamedi
58IgG subclass distribution of total and antigenspecific antibodies in Behçet’s disease patients.Lesley Bergmeier
59Neutrophil Elastase and Secretory LeukocyteProtease Inhibitor: Investigating their role in thesaliva of Behçet’s disease patients.Tanya Novak
William Harvey ResearchInstitute
60Inflammatory cytokines induce pericyte shapechange in vivo: role in facilitating leukocytetransmigration?Doris Proebstl
61Development of a latent IL-17 antagonist foreffective gene therapy of rheumatoid arthritis.Gayatri Mittal
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Poster Presentations – Pathology Museum (cont)
22 Queen Mary, University of London
62Gene expression and whole epigenome analysis ina model of foetal programming: the effect of folicacid.Gioia Altobelli and Irina Bogdarina
63Generation of Schwann cell specific knockoutmice reveals novel expression profile andfunctions for JAM-C.Bartomeu Colom
64The role of hedgehog signalling and primary cilia inadrenal development and function.Kathryn Cogger
65Expression of ghrelin o-acyltransferase (GOAT),the ghrelin acylation enzyme, in various humantissues.Chung Thong Lim
66WNT3A modulates chondrocyte phenotypethrough activation of both canonical and non-canonical pathways.Giovanna Nalesso
67Characterization of interfollicular large B cells, anew subpopulation of B lymphocytes, in tertiarylymphoid organs in rheumatic autoimmunediseases.Elisa Corsiero
68Rheumatoid synovial fibroblasts support aidexpression and IG class-switching in B cells via abaff-dependent TLR3-stimulated pathway.Yvonne Kam
69Syndecan-2 core protein directly interacts with theprotein tyrosine phosphatase CD148/PTPRJ topromote integrin-mediated adhesion.James Whiteford
70Transient exposure of macrophages to p38 MAPKinhibition conditions cell responses through MAPKactivated protein kinase-2 (MK-2) regulation.Dr Nasser Malik
71Identification of differential binding sites forFPR2/ALX ligands and AnxA1 receptor-mediatedresponses.Stefania Bena
72Human neutrophils (PMN) migrating across thegingival crevice during acture capsaicin challengeare fully activated.Alex Speight
73Coronary artery disease related genetic variant onchromosome 10q11 is associated with carotidintima-media thickness and atherosclerosis.Ross Laxton
74Aspirin augments the anti-platelet effects of partialbut not complete P2Y12 receptor blockade.Nicholas Kirkby
75Different effects of angiotensin ii and angiotensin-(1-7) on vascular smooth muscle cell proliferationand migration.Feng Zhang
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Queen Mary, University of London 23
With thanks to the Barts and The LondonCharitable Foundation for their continued
support of William Harvey Day.
76Establishing 3D cultures of immortalizedchondrocytes to test anti-inflammatory andchondroprotective drugs.Karin Greco
77Involvement of autoimmunity in the pathogenesisof aggressive periodontitis.Dr Assi Hendler
78The use of a 96-well plate-based plateletaggregation methods as a replacement fortraditional light transmission aggregometry inclinical settings.Melissa Chan
79Molecular and cellular evolution of functionaltertiary lymphoid structures in salivary glands ofNOD mice: inhibition of the lymphotoxin-bpathway.Elisa Astorri
80AP214, a new aMSH analogue, possesses anti-inflammatory activities.Trinidad Montero
81Targeted cytokine intervention to arrestatherosclerosis development in vivo.Dr Sandrine Vessillier
82Targeting therapeutics to Arthritic joints.Chris Hughes
83Sequential gene expression profiles followingcardiac surgery involving cardiopulmonarybypass.Eduardo Svoren
84Engineering oligodendrocyte progenitors whosegrowth and differentiation can be controlled bydoxycycline.Alexander Annenkov
85Heightened basal immune surveillance explainssex-differences in acute inflammatory responses.Dr Ramona Scotland
86Sex specific Role for tRPV1 in pressure inducedconstriction of resistance arteries.Kristen Bubb
87The role of primary cilia mediated hedgehogsignalling in chondrocyte mechanobiology.Clare Davis
88Identification of a novel mediator capable ofdampening inflammation in vivo and enhancingphagocytosis through ChemR23.Jenna Cash
89Progenitor cells in the adrenal cortex: focus onSonic Hedgehog (Shh) and Preadipocyte Factor 1(Pref-1).Leonardo Guasti
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90Identification of interacting partners via yeast-two-hybrid screening for the ataxia protein sacsin.David Parfitt
91Generation and analysis of synthetic inflammationresponsive promoters.Hodan Mohamed
92Dynamics of Melanocortin-4 Receptor processingat the endoplasmic reticulum.Nalini Ramnarace
93Why does MRAP2 fail to save FamilialGlucocorticoid Deficiency type 2 patients?Rebecca Gorrigan
94Evaluation of the interaction ofphosphodiesterases 2A and 4A5 with the arylhydrocarbon receptor interacting protein inpituitary cells.Carole Lennox
95In Silico enzyme and receptor fit screening ofdiglucopyranosylamines: a novel application fordetermining mechanism of action of novel drugcandidates.Dr Michael Seed
96Post-translational modification of type II collagen:the link between type 1 diabetes and rheumatoidarthritis.Rocky Strollo
97Development of novel recombinantbiotherapeutics for treatment of Arthritis.Tahereh Kamalati
98Anti-inflammatory effects of prednisone and acleavage-resistant form of Annexin 1 in immunecomplex-mediated Arthritis.Dr Kristin Kornerup
99Differential mobilisation of neutrophils in femalesunderlies sex-differences in ischaemia/reperfusioninjury.Shimona Madalli
100Autocrine/Paracrine CXCR1/CXCR2 signalling isrequired for the phenotypic stability of articularchondrocytes.Jo Sherwood
101Dose-dependent effects of dopexamine on indicesof shock and organ dysfunction in a rodent modelof laparotomy and endotoxaemia.Dr Mansoor Bangash
Wolfson Institute ofPreventive Medicine102Inflammation, depression and quality of life incancer patients.Miss Jo Archer
24 Queen Mary, University of London
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103Effect of body mass index on recurrence inhormone receptor positive early breast cancer – Aretrospective exploratory analysis from the ATACtrial.Ivana Sestak
104Down syndrome: screening and prenataldiagnosis regionally in England and Wales 1989-2008.Elizabeth De Souza and Joan Morris
105C-reactive protein in screening for coronary heartdisease.David Wald and Jon Bestwick
106Environmental Noise exposure, early biologicalrisk and mental health in 9-10 year old children: across-sectional field study.Rosanna Crombie
107How is coordination of nonverbal behaviour ininteraction influenced by the presence of a patientwith schizophrenia?Mary Lavelle
108Investigating clustering in Edwards syndrome.James Cook
109Novel diagnostic and prognostic characteristics ofDNA methylated genes and their combinations inProstate cancer.Natasa Vasiljevic
110A pilot study to assess the feasibility andacceptability of Child-parent screening for FamilialHypercholesterolaemia.Angela Godoy
111Risk screening converter – an interactive, simpleassessment tool to see whether a risk factor islikely to be a useful screening test.Joan Morris
112DNA Methylation profiling of 30 candidate genesreveals novel diagnostic biomarkers in Breastcancer.Mangesh Thorat
113The incidence of venous thromboembolism (VTE)in East London.Peter MacCallum
114Psychiatric patients’ views of involuntary hospitaladmission: a prospective study in 11 Europeancountries.Claudia Dougall
Newham University HospitalNHS Trust115Preventing Venous Thromboembolism is not a tickbox exercise.Emma Cottrell
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116A review of HaN in a district general hospital bymedical students.Dr Carlo Prina
Tower Hamlets Primary Care Trust117Ethnicity specific cardiovascular risk factors inadolescents: A pilot cross-sectional comparison ofBritish South Asian and White males.Steph Hemmings
118A modelling approach to aid the understanding ofhigh volume image guided injection (HVIGI) inrecalcitrant Achilles tendinopathy.Dr Richard Twycross-Lewis
University College London119Prevalence of sequence variants inphosphodiesterase enzyme 6C (PDE6C) in 8patients with Late Onset Achromatopsia.James Berwin
Institute of Cancer120Functional and clinical significance of loss of thetumour- suppressor MMP-8 in myoepithelial cellsof DCIS.Muguet Sarper
121A schools population based study of indoor vs.outdoor exercise and the contribution of vitamin Dto fitness, health and academic performance.Lucy Battery and Professor Tim Oliver
122Meta-analysis of impact of lack of circumcisionand Vitamin D deficiency on occurrence ofprostate cancer.Professor R T D Oliver
The Blizard Institute of Celland Molecular Science123Characterising a novel animal model of thymiccarcinoma.Asad Mahmood
124Impairment of oesophageal mucosal integrity afterrepetitive exposure to weakly acidic solutions: Anin vitro model to study mechanisms of persistentsymptoms in refractory gastro-oesophageal refluxdisease.Dr Yasotha Duraisamy
125The effects of EGFR inhibition on cancer stemcells in head and neck squamous cell carcinomacell lines.Samim Ghorbanian
126Docosahexaenoic acid is neuroprotective afterspinal cord compression injury in the mouse.Siew-Na Lim
26 Queen Mary, University of London
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