Why R03?

Why R03?Something is better than nothingThe R03 (Small Grant) mechanism supports small research projects that can be carried out in a short period of time with limited resources.Up to two yearsDirect costs $50,000 per year The R03 cannot be renewed One resubmission (A1) is allowedNo preliminary data are required but may be included if available.A doctoral student may not apply for an R03So, you may consider an R03 when you have:A novel, biomedically relevant idea Expertise and facilities to test your ideaNo (or little) preliminary dataYou need to present a hypothesis and suggest methods, preferably innovative, to test this hypothesis. You want to test if this new approach is feasible.You may propose to develop a new technology. Pilot or feasibility studies Secondary analysis of existing data Small, self-contained research projects Development of research methodology Development of new research technology

NIH-formulated Types of R03 Projects : Unfortunately, not all NIH Institutes accept investigator-initiated R03 proposals.3R03 Participating Institutes and Centers (11):

NIH Institutes and Centers that accept investigator-initiated R03 applications in response to the Parent R03 Announcement - (PA-11-262): NHGRI, NIA, NIAAA, NIAID, NIBIB, NICHD, NIDA, NIEHS, NIMH, NINDS, NINR

R03 Non-Participating Institutes and Centers (13):

NIH Institutes and Centers that DO NOT ACCEPT R03 applications in response to the Parent R03 Announcement but ONLY accept R03 applications in response to their specific funding opportunity announcements: FIC, NCATS, NCCAM, NCI, NEI, NHLBI, NIAMS, NIDCD, NIDCR, NIDDK, NIGMS, NLM, ORIP.

NIH Institutes and Centers that DO NOT use the R03 mechanism (1):

NIMHD.How to choose between R03 and R21?R21 is a Exploratory/Developmental Grant Up to two years Total direct cost $275,000Cannot be renewed One resubmission (A1) is allowedNo preliminary data are required but may be includedExploratory, novel studies that break new ground or extend previous discoveries toward new directions High risk-- high reward studies that may lead to a breakthrough in a particular area, or result in novel techniques, agents, methodologies, models...Projects should be distinct from those supported through the traditional R01 mechanism.Critique 1 notes that solid preliminary data would be required to demonstrate likelihood of success. Meanwhile, R03 guidelines stress that Preliminary data are not required. A strong conceptual framework and an innovative approach to the problem are the criteria of an R03 proposal.From the Introduction of my amended submission:It is stated that Dr. Tatulian has no direct experience with the synthesis of peptides and with the proposed native ligation strategies This is simply not true because we have been among the pioneers of creating segmentally labeled, semi-synthetic proteins and structural analysis by FTIR. From the final summary statement:the principal investigator was highly responsive to previous critiques Overall, the panel members expressed considerable enthusiasm for this outstanding application that is likely to have a high impact on the field of protein toxin translocation. Previous concerns included the lack of preliminary data, the perception that the PI lacked expertise to generate semi-synthetic peptides, the ability to generate T-domain in functional form... These critiques are countered by arguments that preliminary data is not required for the R03 mechanism where the goal is to establish feasibility (or not) and the PIs documented success in using semi-synthetic synthesis in his previous work.