Where is transferrin synthesised? Where does transferrin go to? How transferrin is dealt with by the protein trafficking pathway\ How does transferrin bind to iron? How transferrin is taken up by the cell How is transferrin targeted to the correct location? Why is iron released at the location? What happens to the transferrin afterwards? Free ferric ions are toxic; but cells need iron to build many of their proteins including cytochromes and hemoglobin Ferric ions are carried in the blood tightly bound to transferrin as ferritransferrin Dividing cells, which need the iron, gain it by binding the ferritransferrin to transferrin receptors on their surfaces. These receptors also have a high affinity for coated pits.
Where is transferrin synthesised?Where does transferrin go
to?How transferrin is dealt with by the protein trafficking
pathway\How does transferrin bind to iron?How transferrin is taken
up by the cellHow is transferrin targeted to the correct
location?Why is iron released at the location?What happens to the
transferrin afterwards?
Free ferric ions are toxic; but cells need iron to build many of
their proteins includingcytochromesandhemoglobinFerric ions are
carried in the blood tightly bound to transferrin as
ferritransferrinDividing cells, which need the iron, gain it by
binding the ferritransferrin to transferrin receptors on their
surfaces. These receptors also have a high affinity for coated
pits.
