What does the future hold?

SAPHIRECCP4 librariesProgram DevelopmentsMore automation3D viewer ProjectCCP4 Study Weekend 2003

BAR!

SAPHIRE• Reads protein sequences in SwissProt format either stored locally or when downloaded from a specified database. This sequence can then be edited for future use.• Will be expanded further to include sequence alignment functions for model building.

Author: Pryank Patel, CCP4

CCP4 Libraries

• Full functionality of CCP4 Libraries in C and C++

• Legacy applications will still work!

• Library calls can be used directly from scripts.

• Faster development of software.

• Many existing applications being translated into C and C++

Program developments: PHASER

Independent development of Randy Read and co-workers.Maximum likelihood methods for SIR/MIR, SAD/MAD and MR accounting for pairwise correlations between datasets. Fully integrated program for experimental phasing and molecular replacement, including heavy atom location.To be included in CCP4, and ccp4i interface being developed.

phaser

More Automation

3D Viewer Project

AUTOSTRUCTThe core of this project is to bring together the efforts of most of the major European software developers for X-ray crystallography towards achieving the goal of making the procedure of structure solution more effective, in terms of using more powerful algorithms to solve, refine and validate structures. The software should not only be as transparent as possible to the end user, but also assist in the case of user inexperience.

www.autostruct.org

CCP4 Study Weekend 2003

Venue : University of YorkDate : 3/4 January 2003Subject : Experimental PhasingScientific Organisers:

Neil McDonald (Birbeck College, London)Airlie McCoy (University of Cambridge)

Questionnaire

Please fill in your Questionnaire and return it to one of the speakers or to the CCP4 stand.

Help us to help you!

Acknowledgements

Daresbury LaboratoryMartyn Winn - cmtz, csymAlun Ashton - XMLPeter Briggs - ccp4iCharles Ballard - cmap

European Bioinformatics InstituteKim Henrick - data harvestingEugene Krissinel - mmdb

MRC-LMB, CambridgeAndrew Leslie, Harry Powell, Graeme Winter - mosflmPhil Evans

York UniversityKevin Cowtan - clipper, csymLiz Potterton - MG, ccp4iGarib Murshudov - refmacYao Jia-Xing – acornAlexei Vagin - molrepEleanor Dodson

Cambridge UniversityRandy Read, Airlie McCoy

FundingBBSRC – CCP4EU - AUTOSTRUCT

and many more ...

Thanks Today:

Harry Powell Roberto SteinerBernhard Rupp Steve Prince

Maeri Howard-Eales

The End!

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