WHAT AREFOUNDATIONALSUPPLEMENTS?By Hank Liers, PhD

PRODUCTS DISTRIBUTORS, INC.

MultivitaminsVitamin C / AntioxidantsEssential FatsHigh-RNA Superfoods

Enhancement FormulasSpecific Condition Formulas

We believe everyone should follow a basic supplement program. We call these basic supplements Foundational Supplements because together they provide the essential nutritional building blocks required by everyone. You can significantly improve your health by taking just these supplements.

There are four categories of Foundational Supplements: multivitamins, Vitamin C / antioxidants, essential fats, and High RNA Rejuvenate!™ superfoods. Taking all four types of Foundational Supplements provides the most complete nutrition. Foundational Supplements consist of:

1. MULTIVITAMINS. Foundational nutrition begins with a multivitamin supplement. Multivitamins provide a broad range of basic nutrients required by the body. While many nutrients are obtained from foods, the typical modern diet consumed by most people cannot provide optimal amounts of many important nutrients. A well-designed multivitamin ideally provides both adequate amounts of basic nutrients and natural forms of these nutrients for best assimilation.

2. VITAMIN C / ANTIOXIDANTS. Vitamin C is among the most important nutrients for overall health. It is a powerful antioxidant, and performs many other functions in the body, including supporting immunity and connective tissue integrity. It also exerts synergistic effects when combined with bioflavonoids and other antioxidants.

3. ESSENTIAL FATS. Essential fats are required for health. They serve many critical functions in the body, including supporting cell membrane health, production of substances affecting pain and inflammation, as well as regulating steroid production, hormone synthesis, and nerve transmission. Alpha-linolenic acids (omega-3) and linolenic acid (omega-6) are two basic essential fats. Other important fats are eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and docosahexanoic acid (DHA).

4. HIGH-RNA SUPERFOODS. Rejuvenate!™ superfoods are a revolutionary means for increasing your level of nutrition by leveraging the unique capacities of dietary nucleic acids (RNA, DNA). Pioneer nucleic acid researcher Dr. Benjamin S. Frank showed dietary RNA to be an essential nutrient required for good health, just as important as vitamins, minerals, and other nutrients. He found nucleic acids important for energy production (as ATP), cellular and tissue repair, strong immunity, and metabolic processes, as well as anti-aging functions.

WHAT AREFOUNDATIONALSUPPLEMENTS?

By Hank Liers, PhD

“A high-quality, high-potency multivitamin is the single most important supplement you can take.”

1. A HIGH-QUALITY MULTIVITAMIN

A high-quality, high-potency multivitamin is the single most important supplement you can take. A good multivitamin ensures you receive the optimal amounts of important nutrients. Modern lifestyles create greater demands for critical nutrients that are often less available from foods. Multivitamins help break the cycle of nutrient deficiency. Critical nutrients provided by a good therapeutic multivitamin include a wide range of essential vitamins, minerals, and cofactors. An excellent multivitamin will usually include trace minerals, fat-soluble vitamins (A, E, D, and K), coenzyme B vitamins, magnesium, or other nutrients known to be deficient in most individuals.

Important factors to consider when selecting a multivitamin include high-potency forms, completeness, balance, ease of uptake, and rapid assimilation.

High-potency is important because for most nutrients, the so-called “daily value” is inadequate. This is because daily values are based on minimum amounts required to sustain life rather than the optimal amounts needed for vibrant health. Most people need many times the daily value of vitamins for good health.

Complicating this picture is the fact that individual needs for specific nutrients vary widely. One person’s need for Vitamin C may be average, yet she may need other nutrients in significantly higher amounts. The need for nutrients for any given individual can vary depending upon personal stress (infections, tissue damage, emotional stress), environmental issues (exposure to toxins, sunlight), or nutrient availability in food sources. Because most vitamins (especially water soluble ones) are essentially non-toxic even in large doses, it’s safe to provide your body with larger amounts of critical nutrients. The proper forms of nutrients are another critical

factor because the form will make a major difference in terms of how it is assimilated in the body. For example, Krebs cycle bionutrients (mineral carriers, such as citrates, malates, alpha-ketoglutarates, succinates, or fumarates) are known to be superior precisely because they are the forms naturally recognized in the body. The Krebs cycle (or citric acid cycle) is part of the metabolic pathway used to generate energy (ATP) from nutrients in foods. In contrast, elemental forms of minerals and/or cheaper forms may be more difficult to assimilate because they must be converted into forms the body can use. The biological cost is reduced bioavailability, as well as the cellular energy expense required for metabolic conversion. As you can see, forms matter!

“A high-quality, high-potency multivitamin is the single most important supplement you can take.”

Other important factors include completeness and balance. Completeness is important in a multivitamin because the body requires a wide range of nutrients working together to create and sustain health.

Many multivitamins are neither complete nor balanced. This relates partly to the fact that multivitamins are often designed without a full understanding of nutrients, forms, or optimal amounts needed. Many commonly available multivitamins incorporate less effective forms, inadequate amounts, and improper ratios of nutrients. This is probably a reflection of the economics of vitamin formulation, as properly putting all of these factors together usually results in more expensive multivitamins. When it comes to multivitamins, you really do get what you pay for.

HPDI offers several balanced and complete multivitamins providing optimal amounts of easily assimilated nutrient forms. These include Hank & Brian’s Mighty Multi-Vite!, Multi Two caps or tabs, and Mini Multi (100% free of excipients). We recommend our capsule formulas because they are the easier to assimilate. However, our tablet formulas are both effective and cost effective. Mini Multi contains no additives and is designed especially for chemically and environmentally sensitive individuals. In addition, children benefit greatly from a multivitamin, and for them we offer our chewable Kids Mighty-Multi!.

2. VITAMIN C / ANTIOXIDANTS

Ever since Linus Pauling’s Vitamin C and the Common Cold, Vitamin C has held a place of esteem among nutritional scientists and health-conscious consumers. Pauling went on to present further studies and to write his bestseller How to Live Longer and Feel Better, in which Vitamin C plays a major role both in his discussion of vitamins and in the supplement regimens he recommends. Even so, Vitamin C remains underutilized by mainstream medicine and under-appreciated for the healing powerhouse it represents.

Vitamin C is a foundational nutrient because it is a potent antioxidant, a powerful immune builder/antiviral, cholesterol controller, and connective tissue builder. In fact, no other vitamin or nutrient can take its place in terms of its contribution to overall health.

In nature, Vitamin C is always combined with bioflavonoids. Bioflavonoids such as rutin, quercetin, catechins, anthocyanidins, and oligomeric proanthocyanidins (OPCs), work synergistically with Vitamin C to create powerful antioxidant effects, counteract inflammation, and strengthen connective tissues. In addition, Vitamin C and bioflavonoids combine with other antioxidants (including glutathione, R-lipoic acid, and selenium) in a process called “redox cycling.”

We offer a variety of Vitamin C products, including formulas with bioflavonoids. These include Ultimate Protector, PRO-C, OPC-C, Buffered Vitamin C tabs, and Buffered Vitamin C powder. We

“Completeness is important in a multivitamin because the body requires a wide range of nutrients working together to create and sustain health.”

typically recommend taking a buffered Vitamin C product to prevent acidosis and help maintain proper pH levels in the body. We buffer our Vitamin C products using both magnesium and calcium because magnesium is often the master nutrient in the metabolism of calcium.

Ultimate Protector™ is a next generation cell protection formula that delivers 250 mg of buffered Vitamin C, a full spectrum of high ORAC antioxidants, and Nrf2 activators in a single product. Ultimate Protector is a quantum leap forward in providing total antioxidant protection from all types of free-radicals. At 486,000 ORAC5 units per serving, this is the most potent antioxidant formula on the market.

PRO-C™ is our signature encapsulated Vitamin C antioxidant formula that contains 500 mg of buffered Vitamin C; grape extract (from pulp, skin, and seed); green tea extract; NAC; reduced glutathione; R-lipoic acid; selenium, and other synergistic nutrients. It contains multiple Nrf2 activators that are somewhat different than Ultimate Protector™.

OPC-C™ contains 500 mg of buffered C plus 25 mg grape seed, skin, and stem extract. This is another superb formula that provides Vitamin C plus antioxidants from grape extract. OPC-C™ does not contain green tea extract or as many antioxidants as PRO-C™, but it supplies both therapeutic levels of Vitamin C plus substantial antioxidant protection. Our buffered Vitamin C products (Buffered Vitamin C tabs and powder) provide a cost-effective means to obtain therapeutic levels of Vitamin C.

3. ESSENTIAL FATS

Essential fats are needed for life-sustaining biological processes rather than simply acting as food-based sources of energy (as do many other non-essential fatty acids). Humans must ingest essential fatty acids for survival.

Essential fats serve many different functions in the body. These functions include being modified to make substances that affect pain and inflammation; regulating steroid production and hormone synthesis; regulating pressure in the eyes, joints and blood vessels; modulating the immune response; regulating smooth muscle for oxygen transport from red blood cells to tissues; proper kidney function and fluid balance; preventing clumping of red blood cells; regulating mood and depression, and regulating nerve transmission.

Every cell and organelle within the cells are encased and protected by a membrane made of phospholipids. A major component of these phospholipids are essential fatty acids that control membrane fluidity and the ability to pass important nutrients into the cells and toxins out of the cells. Without adequate essential fats, the cell membranes can become rigid and dysfunctional.

There are two basic essential fats: alpha-linoleic acid (omega-3) and linolenic acid (omega-6). Other fats are sometimes included as being essential fats, including

“Vitamin C remains underutilized by mainstream medicine and under-appreciatedfor the healing powerhouse it represents.”

“Essential fats are needed for life-sustaining biological processes rather than simply acting as food-based sources of energy.”

gamma-linolenic acid (GLA), an important omega-6 fatty acid, and eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA), important omega-3 fatty acids. Although these other fats can be made in the body from alpha-linolenic acid (ALA) and linoleic acid (LA), it is much more efficient to provide them directly.

More people are consuming fish, fish oils, and vegetarian sources of essential fats, including flax or chia seeds. However, the need for supplementing diet with essential fats to ensure adequate daily intake has never been greater than today.

We offer two essential fats products: Hank & Brian’s Essential Fats Plus E and Omega Plus. Both of these contain EPA and DHA from highly purified fish oils, GLA from cold-processed borage oil, and full spectrum Vitamin E consisting of all eight natural forms of tocotrienols and tocopherols. These mixed forms of Vitamin E perform many beneficial functions in the body (such as lowering cholesterol and clearing plaque out of blood vessels) and also protect the essential fats from oxidizing in the capsule and in your body. The ratio of EPA to GLA in these products is 4:1, which based upon research is considered the ideal ratio for optimal effects in the body. Essential Fats Plus E also contains astaxanthin, a carotenoid, that is an extremely powerful fat-soluble antioxidant.

The fish oils in our essential fatty acid supplements are molecularly distilled for ultra-high purity. Every batch of fish oil is tested to ensure freshness and guaranteed to contain insignificant levels of heavy metals, PCBs, pesticides, and other organic chemical contaminants. These supplements do not contain hydrogenated oils, artificial colors, or artificial preservatives.

For vegetarians we recommend flax seeds or chia seeds, two of nature’s best plant sources of alpha-linolenic acid (ALA) and linoleic acid (LA). These are excellent alternative sources of EFAs for individuals not inclined to use fish oil products.

4. HIGH-RNA SUPERFOODS

Rejuvenate!™ superfoods are a recent addition to HPDI’s Foundational Supplements. Our development of high RNA superfoods was inspired by the work of Dr. Benjamin S. Frank. After more than twenty years of clinical research, Dr. Frank asserted in his book Nucleic Acid Nutrition and Therapy that nucleic acids are “essential nutrients of human beings.” Dr. Frank considered nucleic acids and nucleotides to be a dietary category just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids.

Dr. Frank acknowledged the body’s capacity to synthesize some nucleic acids, yet cited marked improvements in degenerative conditions as the clearest evidence for

nucleic acids as essential nutrients. In particular, he noted the health effects resulting even from relatively small intakes of nucleic acids (energizing effects, anti-anoxia effects, rejuvenation, and greater vitality). Dr. Frank found he could not obtain such improvements in his subjects by increasing only the intake of vitamins, minerals, proteins, or other essential nutrients.

Dr. Frank wrote: ”Nucleic acids are an essential nutrient in our daily diets, and... optimal health and reduced aging are clearly related to their intake, more than to any other nutrient. Nucleic acids in our diets are of paramount importance for the repairing of molecular and gross tissue degeneration, and for combating the process of aging by simple, effective and essentially non-toxic, natural means.”

In addition, Dr. Frank described the processes by which nucleic acids dramatically increase cellular energy. Nucleic acids boost energy levels by significantly increasing production of the “high-energy” molecule ATP (adenosine triphosphate). The body requires the energy from ATP for many purposes,

including cellular and tissue repair, metabolism, digestion, building a strong immune system, and many other processes.

Our experience confirms Dr. Frank’s conclusion that dietary nucleic acids are essential nutrients required for health. We developed Rejuvenate!™ superfoods to provide dietary nucleic acids in sufficient quantity to exceed the body’s needs. We have received many letters from our customers about the benefits they’ve received from using our high-RNA Rejuvenate!™ superfoods.

All three Rejuvenate!™ superfoods contain at least 340 mg of RNA/DNA (per serving) from a variety of vegetable sources including chlorella, nutritional yeast, yeast RNA/DNA extracts, spirulina, and chlorella growth factor. In addition, they all provide nutrients such as Vitamin B12, folinic acid, magnesium, and Vitamin C that support the body in its efforts to internally build nucleic acids. Furthermore, they all contain superfoods that provide additional key nutrients and help to optimize metabolism and health. For more information, please visit our website, or call us.

Rejuvenate!™ Original is especially useful for rapid detoxification because it contains high levels of chlorella, and does not contain added protein or a multivitamin complex.

Rejuvenate!™ PLUS is a “sweet greens” formula that contains less detoxifying chlorella than Rejuvenate!™ Original. Rejuvenate!™ PLUS offers a broad array of green foods (chlorella, spirulina, alfalfa grass, VitaVeggie®, and organic vegetable sprouts powder) along with high levels of protein, a complete multivitamin, essential fats, fiber, enzymes, and antioxidants.

Rejuvenate!™ Berries & Herbs is popular with persons seeking a great tasting, nutritionally complete superfood. Rejuvenate!™ Berries & Herbs offers high levels of protein, a complete multivitamin, essential fats, fiber, enzymes, and antioxidants. Also, it contains an extensive herbal cell protection formula. Rejuvenate!™ Berries & Herbs contains no greens and is loved for its delicious berry flavor.

“Dr. Frank considered nucleic acids and nucleotides to be a dietary category just as essential for humans as vitamins, minerals, proteins, carbohydrates, and lipids.”

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FOUNDATIONAL SUPPLEMENTS ARE A POWERFUL SYNERGY FOR HEALTH

Foundational Supplements work together synergistically to leverage each other in ways that exceed the effects when supplements are taken individually. The best news with respect to dietary nucleic acids (especially RNA) is that while they are essential nutrients, their inclusion in Foundational Supplements leverages their effects by facilitating the synergy between all of the foundational nutrients. This synergy means the total package of nutrients delivered by all Foundational Supplements exceeds the health-building nutrition any single foundational formula delivers. That’s synergy in action!

Synergy is the primary reason we emphasize Foundational Supplements as everyone’s starting place for creating optimal nutritional health. We consistently find that one of the most successful means for creating health is to take all four types of Foundational Supplements each day.

DAILY NUTRITIONAL BENEFITS PROVIDED BY FOUNDATIONAL SUPPLEMENTS

Foundational Supplements provide significant levels of essential nutrients. Table 1 compares the levels of 35 nutrients provided by Foundational Supplements to the Daily Value (DV).

We selected four of our most popular Foundational Supplements for this comparison. Nutrient values are based on a daily serving, in this case 4 capsules of Mighty Multi-VIte, 3 capsules of PRO-C, 6 capsules of Omega Plus, and 2 scoops of Rejuvenate! Berries & Herbs.

In the comparison chart we’ve shown the nutrients for which there is a Daily Value in the four Foundational Supplements to determine “Total in Program.” The final column indicates the ratio of “Total in Program” to Daily Value.

“Synergy is the primary reason we emphasize Foundational Supplements as everyone’s starting place for creating optimal nutritional health. ”

NUTRIENT DAILY VALUE

MIGHTY MULTI-VITE

PRO-C OMEGA PLUS

REJUVENATE B&H

TOTAL IN PROGRAM

PROGRAM RATIO TO DAILY VALUE

Total Fat 65 g 0 0 1.0 4.0 5.0 0.077

Saturated Fatty Acids 20 g 0 0 .2 0.5 0.7 0.035

Cholesterol 300 mg 0 0 0 0 0 0

Sodium 2,400 mg 0 0 0 50 50 .02

Chloride 3,400 mg 0 0 0 NA NA NA

Potassium 3,500 mg 99 0 0 >100 >199 >0.06

Total Carbohydrates 300 g 0 0 0 15.0 15.0 0.05

Dietary Fiber 25 g 0 0 0 6.0 6.0 0.24

Protein 50g 0 0 0 12 12 0.24

Vitamin A 5,000 IU 7,500 0 0 0 7,500 1.5

Vitamin C 60 mg 250 1,500 0 433 2,183 36.4

Calcium 1,000 mg 100 69 0 80 249 0.25

Iron 18 mg 0 0 0 4.5 4.5 0.25

Vitamin D 400 IU 200 0 0 1,000 1,200 3.0

Vitamin E 30 IU 200 0 8 90 298 9.9

Vitamin K 80 mcg 200 0 0 500 700 8.8

Vitamin B1 / Thiamin 1.5 mg 25 0 0 4.5 29.5 19.7

Vitamin B2 / Riboflavin 1.7 mg 25 1 0 5.1 31.1 18.3

Vitamin B3 / Niacin 20 mg 60 0 0 60 120 6.0

Vitamin B6 2 mg 40 1 0 6.0 47 23.5

Folate 400 mcg 800 0 0 800 1600 4.0

Vitamin B12 6 mcg 200 0 0 200 400 73

Biotin 300 mcg 500 0 0 900 1,400 4.7

Pantothenic Acid 10 mg 65 0 0 43 108 10.8

Phosphorus 1,000 mg 0 0 0 NA NA NA

Iodine 150 mcg 0 0 0 500 500 3.3

Magnesium 400 mg 100 69 0 168 337 0.84

Zinc 15 mg 20 6 0 NA 26 1.7

Copper 2.0 mg 2 0 0 NA 2 1.0

Manganese 2.0 mg 5 0 0 NA 5 2.5

Chromium 120 mcg 200 0 0 NA 200 1.2

Molybdenum 75 mcg 100 0 0 NA 100 1.3

Selenium 70 mcg 75 30 0 NA 105 1.5

Omega 3 (EPA/DHA/ALA) 1.6 g 0 0 0.6 0.54 1.14 0.71

Omega 6 (LA) 15 g 0 0 0.21 0.36 0.57 0.04

FOUNDATIONAL SUPPLEMENTS

Table 1: Ratio of Nutrients Provided by Foundational Supplements to Daily Value

1. When values are not available, they are denoted “NA.”2. Daily Values are not established for omega-3 and omega-6 essential fats. We use the “Adequate Intake” figures established by the Foods and Nutrition Board of the National Academy of Sciences.3. Nutrients with a low Program Ratio (or listed as “NA”) must be obtained from diet. These nutrients include total fat, protein, fiber, essential fats, and macrominerals.4. Ratio to DV varies by nutrient. Desirable ratios for trace minerals range from 1 to 5, water-soluble vitamins range from 10 to 75, and fat-soluable vitamins range from 2 to 10.5. There are other important nutrients in Foundational Supplements for which no DV is established. These include bioflavonoids, antioxidants, RNA, herbs, and other nutrients.

Explanatory Notes