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CELLULAR BIOLOGY OF METABOLIC BONE DISEASESCreated by darti I wibisono

parathyroidVit D/calciumEstrogen deficiencyDrug/steroid

strstressPhysic, chemical , thermal,ectRegular remodelingIrregular remodelingOsteoid formation,ectFibrous dysplasia.ectBONE CALCIFICATIONCa lcium phosphate precipitation in osteoid ?OSTEOBLASTMINERALSALKALINE PHOSPHATASELow Blood CaparathyroidParathormon(PTH)BONE direct action induces osteolysis and osteoclasisBONE AND CALCIUM HOMEOSTASISRESTORATION

BONE TURNOVERBone resorptionBone formationDISORDERS OF REMODELINGOSTEOPORESISNORMAL BONE

FORMATIONRESORPTIONFORMATIONRESORPTIONOSTEOPORESISosteopeniaosteoporesisosteomalaciaIncreased porosity of bones(Loss of mineral and non mineral components of the bone)Vit. D deficiencyRADIOLOGYOSTEOPORESISA SYSTEMIC DISEASES Characterised by : 1.Low bone mass2.Micro architectural deterioration of bone3.An increase in bone fragility and susceptibility to fractureA patient is said to have osteoporesis if bone mineral density > 2,5Collapse vertebral bodyPOROTIC BONE :Wide honey comb spacesdartiPEAK BONE MASSTHRESHOLD FOR FRACTUREMENOPAUSEfemalemaledartiGenetik predispositionNutritionExcerciseLOW PEAK BONE MASSLOW BONE MASSSTEROID,ALCOHOL,ECTfracturePEAK BONE MASSOSTEOMALACIAFAILURE CALCIFICATIONVIT D deficiencyFailure normal remodelling RICKETSadultGrowing childDisturbance at growing ends of long boneDEVELOPMENTAL ABNORMALITIESGENERELISED ABNORMALITIESLOCAL ABNORMALITIES1 .cartilage cells 2.The defect is in the osteoblast fail to synthesise collagen properly. *Type I collagen genes chromosome 7 and 17 3.Osteoclasts are absent or defective

CLEFT PALATESPINA BIFIDASCOLIOSISECTACHONDROPLASIA DWARFISMIrregular development of cartilage cellsOSTEOGENESIS IMPERFECTA :*The defect is in the osTeoblast which fail to synthesise collagen properly*Abnormal in :Type1 collagen genes,shromosome 7 and 17OSTEOPETROSIS (MARBLE BONE DISEASE OF ALBERS-SCNBERG)

Osteoclasts are absent or defectiveBONE MICELLANEUS1.HYPERPARATHYROIDISM CYSTIC SPACE2.HYPERTROPHY (ACROMEGALY)3.FIBROUS DYSPLASIA4.PAGETS DISEASE OF BONE

FractureOsteoarthritisBone Sarcoma

CYSTIC LESIONS IN BONETRUE? BONE DISORDERSCystic aneurysm /degenerationEosiniphilic granulomaGiant Cell Tumor of the boneect