week 3 part 1 lectures.docx

7/23/2019 week 3 part 1 lectures.docx

1/11

Week 3 Lecture 1, Proteins:

Flow of Information

Protein Functions-50% of dry mass of a cell is rotein!

-"ost #aried macromolecule in structure and function!-$cts as te cell&s infrastructure:

-'n(ymes-te macines and factories-cataly(e cemicalreactions!

-)tructural roteins-te i*ways and *irders!-)i*nalin* roteins-te cell&s +senses-

recetors and li*ands!

$mino $cids-Proteins are olymers of amino acidsmonomers!

-0 di.erent amino acids!-$ll amino acids a#e an asymmetric car/onattaced to

-a ydro*en-an amino *rou-a car/oyl *rou-a #aria/le side *rou 2


2/11

4onolar $mino $cids-4onolarydroo/ic-6sually in interior of rotein!

Polar $mino $cids

-Polarydroilic-Polar *rous from ydro*en /onds

7ar*ed $mino $cids-7ar*edydroilic-7ar*ed *rous form ionic /onds-7ar*ed *rous are acid or /asic


3/11

Linkin* $mino $cids-$ deydration reaction links a new monomeramino acid onto te olymer etide!-Linked /y a etide /ond!-8e etide as an amino acid 4-term and a

car/oyl end7-term!

Linkin*

$mino $cids-9uild roteins from 47!-9ack/one is same for all amino acids added ecet roline-)ide cain contains te +information

1 )tructure )e;uence-For eamle:n-ser-e-leu-ro-tr-is-is-*luy-lys-#al-7

-


4/11

3

)tructure 2 >rou Interactions-


5/11

6nfoldin* a Protein-$ rotein re;uires te erfect en#ironment to stay folded andfunctional!-@eat, @, salt concentration


6/11

Week 3 Lecture , 4ucleic $cids:

Function of 4ucleic $cids-6ni;ue amon* all molecules /ecause tey act as a temlate for/uildin*!-


7/11

9uildin* 4ucleic $cids-4ucleic acids are lon* olymers of nucleotides!

4ucleotide 9ack/one-24$ as ri/ose su*ar-


8/11

+cut Py ie+ure as $> sil#er

9ase Pairin*-4itro*enous /ases ydro*en /ond to one anoter!-In


9/11

-7ytosine: >uanine-In 24$

-$denine: 6racil-7ytosine: >uanine

$ and 8 a#e ydro*en /onds$ and 6 a#e ydro*en /onds7 and > a#e 3 ydro*en /onds


10/11


11/11

Documents

week 3 part 1 lectures.docx