Ward 6 Case Study

8/8/2019 Ward 6 Case Study

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PATHOPYSIOLOGY

HOST AGENT


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HOST AGENT

ENVIRONMENT

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entry of bacteria to upper respiratory tract

X-linked gene deficiency through inhalation, aspiration or direct spread from infected sites

Defective G6PD gene Infection

^Susceptibility to hemolysis and infection subsequent inflammation occurs

Exposure to infections, severe stress, mucus secretion initiation of glottic and cough reflex nasopharyngeal defensesand foods (fava beans) (manifestation of productive cough and secretions)

oxidation of RBC effectiveness of defenses due to exhaustion of defense mechanisms

inability to generate NADPH entry of bacteria to LRT

Hemolytic Anemia tea-colored urine

drained Sept. 27,2010 Macrophages digest bacteria and Inflammation of alveolar epithelium and lung

disposal of destroyed RBC in the liver

present antigen to immune system Blockage in alveolar sac

A B C

A B C


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A B C

Inc. production of bilirubin phagocyte migration to site of invasion Pooling of blood, mucus, and fluids in alveoli

Accumulation of bilirubin to diff. Destruction of bacteria and release of cytokines (auscultatory rales on both lung fields)

parts of the body and in the skin.

Bilirubin passes through Stimulates hypothalamus to body temperature

blood-brain barrier Vascular congestion alveolar edema

Fever

Subsequent Brain damage (Kernicterus)

Pulmonary Congestion

DEATH

Massive outpouring of leukocytes

accompanied by intra alveolar hemorrhage

Red Hepatization

erythrocytes neutrophils desquamated epithelial cells firbrin formation

Grey Hepatization

Blood clot formation

fibropurulent exudates RBC disintegration hemosiderin formation disrupts circulation to organs

B2

A1


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A1 B2 C2

Resolution stage Systemic hypoxia pressure in the alveoli

Resorption and restoration multiple organ failure Destruction of alveolar epithelium pleural effusi

of pulmonary architecture

DEATH occlusion of bronchi and alveoli limits lung expa

Decrease of alveolar O2 tension impaired breath

Perfusion mismatch Inadequate oxyg

Venous blood enters underventilated areaand travel to the left side of the heart

poorly oxygenated

mixture of oxygenated and unoxygenated or poorly oxygenated blood

arterial hypoxemia hypercapnia

ischemia and cyanosis

Systemic Hypoxemia multiple o


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