Volume 112 (3)

The Company of Biologists Limited

INFORMATION ABOUT THE JOURNALDEVELOPMENT (ISSN 0950-1991) is a continuation of Journal of Embryology and Experimental Morphology (ISSN 0022-0752).

Development <The aim of Development is to act as aforum for all research that offers agenuine insight into mechanisms ofdevelopment. Manuscripts will beconsidered primarily with respect to thisaim.

Studies on both plant and animaldevelopment are welcome and can befocused upon any aspect of thedevelopmental process, at all levels ofbiological organization from themolecular and cellular to the tissuelevels.

What Development offers(i) Wide international circulation(ii) Fast publication - average 13 weeksfrom acceptance(iii) Fast editorial processing(iv) No page charges(v) 200 free reprints(vi) Free colour reproduction (at theeditor's discretion).

Rapid publicatiorDevelopment now offers rapidpublication (average 9 weeks fromacceptance): the following criteriaapply:(i) the revised manuscript isaccompanied by a corresponding word-processor disk(ii) no colour plates(iii) author does not require to seeproofs(iv) 200 free reprints only(v) manuscript conforms to journalstyle i.e. no subediting necessary - seeInformation for contributors,(vi) Figures are labelled in journalstyle.

Subscription ratesUSA, Canada and Mexico: InstitutionalUS$885; Individual US$105.Rest of the World: Institutional £510;Individual £75.(All prices include post and packaging).

Number of issues

Development in 1991 will have 12normal issues and 2 caseboundsupplements. The 12 normal issues willbe in the form of 3 volumes (111, 112,113) each of 4 parts. In 1991 theSupplements will be 'Molecular andCellular Basis of Pattern Formation'and 'Developmental Neurobiology'.

Orders

Orders for 1991, which can be in £Sterling/Dollars or using Access/Visacredit cards, should be sent to PortlandPress Ltd, PO Box 32, Commerce Way,Colchester CO2 8HP, UK[telephone Colchester (0206) 46351;24-hour ordering by Fax (0206) 549331- USA 44 206 549331] or to yournormal agent or bookseller.Orders must be accompanied bypayment.

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Send address corrections toDevelopment, c/o Mercury AirfreightInternational Inc., 2323 RandolphAvenue, Avenel, New Jersey 07001,USA (US Mailing Agent).

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Publication of a paper in this journalimplies that authors will make availablespecialized reagents (for exampleantibodies, DNA probes) to otherscientists in the field who require themfor bona fide purposes.

For detailed instructions to authors,please see back cover.

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(i) Authors may make copies oftheir own papers in this journalwithout seeking permission fromThe Company of Biologists Limited,provided that such copies are for freedistribution only: they must not besold.

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(a) For private study, provided thecopying is done by the personrequiring its use, or by an employeeof the institution to which he/shebelongs, without charge beyond theactual cost of copying.(b) For the production of multiplecopies of such material, to be usedfor bona fide educational purposes,provided this is done by a member ofthe staff of the university, school orother comparable institution, fordistribution without profit to studentmembers of that institution, providedthe copy is made from the originaljournal.

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Dr R. J. Skaer,Company Secretary,The Company of Biologists Limited,Department of Zoology,Downing Street,Cambridge CB2 3EJ,UK.

Cover photographs

Expression of XIHbox 1 antigen during development of the zebrafish pectoral fin. Initially a circular fieldof mesodermal cells express the homeodomain protein. After a fin bud is formed, the expression becomeslocalized to nuclei in the anterior and proximal mesoderm. For further details, see review article by E. DeRobertis, E. A. Morita and K. W. Y. Cho in this issue of Development 112, 669-678. Photos by AndersMolven.

IMPORTANT NOTICE

Owing to unprecedented sales of Development thisyear, our stocks for back issues of 1991 have beensubstantially reduced. We must, therefore, decline totake all new individual subscriptions for 1991. However,a limited number of new institutional subscriptions canstill be fulfilled for the 1991 subscription year, by faxing44 206 549331, while stocks last.

New subscriptions for 1992, both individual andinstitutional, can also be placed - see next issues ofDevelopment.

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The Company of Biologists Limited, founded in 1925, is a 'Company Limited by Guarantee'having tax-exempt charitable status. There is a Board of Directors consisting of about 20professional biologists, two of them appointed annually by the Society for Experimental Biology,who receive no salary or fees for their services. The Company's main function is to own andproduce The Journal of Experimental Biology, the Journal of Cell Science and Development, andto appoint the Editors of these journals. These are part-time appointments held by establishedprofessional biologists of some eminence, and once they have been appointed the Companyexercises no control over editorial policy.

The Company is precluded by its charitable status from making a commercial profit on itsoperations, and its aim is to produce high-quality journals at the lowest possible price. Anysurplus on publishing not required for the journals' reserves is transferred to an Educational TrustFund, which makes substantial grants in aid of societies concerned with the fields of interestcovered by the Company's journals. Grants are also made to conferences and summer schools inthe fields of its journals.

Erratum

Kubiak, J., Paldi, A., Weber, M. and Maro, B.Genetically identical parthenogenetic mouse embryos produced by inhibition of the first meioticcleavage with cytochalasin D. Development 111, 763-770.

50 % of the diploid embryos derived from oocytes that underwent recombination and treatedwith cytochalasin D during the first meiotic division (CCD+-), have a different composition ofthe genome in regards to their mother: they are homozygous in the recombined regions.

This contrasts with the control group (CCD—+), i.e. treated with cytochalasin D during thesecond meiotic division, where all embryos derived from oocytes which underwent recombinationare heterozygous in regards to alleles of the recombined region, while all other genes arehomozygous.

In conclusion: not all, but the great majority of the embryos obtained from a single female bythe method described in our paper (the CCD + — variant) is genetically identical or very similar totheir mother.

Typeset, Printed and Published byThe Company of Biologists Limited

Department of Zoology, University of Cambridge, Downing Street,Cambridge CB2 3EJ

© The Company of Biologists Limited 1991

Molecular BiologistsGet your gene sequences into use

FAST

with Development

Development is working in full cooperation with EMBL Heidelberg to ensure that genesequences submitted to Development are made available in the database immediately the

journal is published.

The authors of all papers accepted for Development that contain gene sequences will thereforebe sent the EMBL sequence data submission form that specifies how sequences can be

submitted to the database and shows how to obtain an accession number.

Sequences that have to be rekeyed by some databases can take up to 6 months before they aremade available to the scientific community.

See Development 108 727-734 for information on submitting sequences.

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BRITISH SOCIETY FOR CELL BIOLOGYAUTUMN MEETING

23rd-25th September, 1991UNIVERSITY OF SOUTHAMPTON

Topics

Epithelial Cell Adhesion and Intercellular Junctions.

Epithelial Morphogenesis.

Signalling via Adhesion Molecules.

Endothelial Cell Adhesion.

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Speakers IncludeR. Kemler (Freiburg)J. Collins (Southampton)B. Stevenson (Edmonton, Alberta)A. Warner (London)A. Sonnenberg (Amsterdam)P. Ekblom (Uppsala)W. Carter (Seattle)M. Bissell (Berkley)J. Bartles (Chicago)T. Fleming (Southampton)M. Dustin (St. Louis)C. Damsky (San Francisco)

POSTER SESSION: Posters on these and related topics will be welcomed.

TRAVELLING FUNDS: Junior members of BSCB may apply for contributionstowards the cost of attending the conference via the Secretary of the Society.

FURTHER INFORMATION AND BOOKING FORMS:Dr. D.R. Garrod, CRC Medical Oncology Unit,

Southampton General HospitalSouthampton, SO9 4XY.

J. Couchman (Birmingham, Al.)C. Haslet (Edinburgh)T. Tedder (Boston)L. Rubin (San Francisco)N. Hogg (London)D. Cheresh (La Jolla)M. Gordon (London)M. Tavassoli (Jackson, Miss.)A. Freedman (Boston)S. Gloor (Zurich)D. Haskard (London)M. Gallatin (Seattle)

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Xenopusembryology

-basic embryological techniques

-mesoderm-inducing factor assays

-lineage labelling

-wholemount immunocytochemistry

- in situ hybridization

Organizers: Jonathan SlackJim Smith

Venue: Department of Zoology and Wadham College,Oxford University, UK. September 8-15 1991.

If you wish .to apply to participate, or requirefurther information about the course content, pleasewr i te to Dr J.M.W.Slack, I.C.R.F. Developmental BiologyUnit, Department of Zoology, South Parks Road, Oxford0X1-3PS, United Kingdom.

/ iPeter Hausen

Metta Riebeselly

Development ofXenopus LaevisAn Atlas of the Histology. ' \

Verlag der Zeitschriftfur Naturforschung

1991. Approx. 160 pp. 42 figs. Hardcover DM 198,- ISBN 3-540-53740-6

Xenopus laevis is the key model for developmental, differential and embryological studies in vertebrates.Using molecular biological techniques it has become possible within the last few years to analyze developmentalprocesses up to the level of genes. On obtaining results it is necessary to correlate them with morphological andhistological stages. This excellent work documents and describes such developmental stages in finite detail.

After an informative introduction to The Early Development of Xenopuslaevis follows the highlight of the book, namely the 42 plates, each consistingof at least four high resolution micrographs. The reader is thus provided witha histological presentation of immaculate quality. Each plate is comple-mented by a schematic diagram describing the details shown on the plate, anadditional scheme indicating the section and an explanatory short text,making this a potentially highly sought after work.

Jointly published by Springer-Verlag Berlin Heidelberg New York London Paris TokyoHong Kong Barcelona and Verlag Zeitschrift fur Naturforschung, Tubingen

a Hddelberjer PUlz 3, W-1000 Berlin 33, F R. Germany D 175 Fifth Ave, New Yoft, NY 10010, USA D 8 Alcundra Rd., London SW19 7JZ, EmlmdD 26, rue del Cirmej, F-75005 Pins, France D 37-3, Hongo 3-chome, Bunkyo-ku, Totyo ! 13, JapanD Room 701, Mirnx Tower, 61 Mody Ro»d, Tiimihujul, Kowloon, Hong Kong D Avingudi Diagonal, 468-4°C, E-08006 Barcelona, Spain im 30 166/V/l

DEVELOPMENT

TRAVELLINGFELLOWSHIPS

The journal is pleased to announce a new travelling fellowship program that is in keepingwith The Company of Biologists' commitment to support research scientists.

In 1991 DEVELOPMENT is offering

FIVE TRAVELLING FELLOWSHIPS

I of up to $1500 each

Graduate and postdoctoral students are invited to apply to the Editors in 1991 for funds toassist travel and expenses involved in visits to other laboratories.

Applications, which should be accompanied by a curriculum vitae, an account of thework to be done and a full breakdown of the costs involved, should include a letter ofrecommendation from the head of the laboratory in which the applicant is presentlyworking and from the head of the laboratory in which the work will be done.

Applications should be sent to C. C. WylieThe Company of Biologists Limited

Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK

The Editors in awarding the Fellowships will be guided by the excellence of thecandidates, and the importance and innovative quality of the work to be done.