Vasc ula ta 2019

Presented by North Americ an Vasc ular Biology Organization (NAVBO)

& The Medic al College of Wisc onsin

Sinc e 2004, Vasc ula ta summer c ourse have been hosted annua lly by ac ademic institutions in va rious pa rts of the USA. Vasc ula ta is a North Americ an Vasc ula r Biology Organiza tion (NAVBO)-sponsored event tha t unanimously c hose Med ic a l College of Wisc onsin (MCW) in Milwaukee, WI, as the host of the 2019 Vasc ula ta c onferenc e. This three-and-one-ha lf-day educ a tiona l c onferenc e introduc es the basic s of vasc ula r b iology (heart, lung, b lood and sleep) and its role in d isease, thus p rovid ing a ttendees with a unique lea rning experienc e in a d isc ip line not c omprehensively c overed in textbooks or even by c ourses in most universities.

The meeting a t MCW will showc ase the loc a l ac ademic environment, espec ia lly vasc ula r b iology and hematology-minded researc hers to the sc ientific c ommunity. Southeastern Wisc onsin-based institutions suc h as The Child ren?s Hosp ita l of Wisc onsin (CHW), Blood Researc h Institute (BRI) and Centers (MCW Card iovasc ula r Center (CVC), Clinic a l Transla tiona l and Sc ienc e Institute (CTSI) will jo intly host this meeting on the MCW c ampus. MCW is a one-of-its-kind ac ademic med ic a l c enter with a ric h history of c a rd iovasc ula r and b lood researc h. Emphasis a t the MCW Vasc ula ta 2019 c onferenc e is on short seminars c overing a defined c urric ulum, with inc reased foc us on app lying knowledge ga ined from basic vasc ula r b iology mec hanisms to d iseases assoc ia ted with the vasc ula ture. Seminars a re followed by hands-on workshops on tec hnolog ies emerg ing in the field and skills assoc ia ted with c a reer enhanc ement. This year, NAVBO in c ollabora tion with MCW will introduc e a new ?mentoring-engagement p lan,? a t Vasc ula ta 2019. This long-term mentoring p lan for pa rtic ipants is designed to engage tra inees and ma inta in mentoring rela tionships long a fter the c onferenc e has c onc luded . The goa l of this p rogram is to inc rease tra inee suc c ess and retention ra tes in heart, lung, b lood and sleep researc h. The c onferenc e a t MCW is supported by CHW, MCW, CVC, CTSI, NAVBO, c orpora te sponsors and a generous R13 grant from NHLBI, NIH.

We welc ome a ll of you to Southeastern Wisc onsin and enc ourage you to engage with vasc ula r b iology researc hers, and to make an impac t on the next genera tion of vasc ula r b iolog ists. Enjoy your time in our vib rant c ity!

On behalf of MCW Vasculata Organizing Committee Team Ramani Ramchandran, PhD (Lead) Veronica Flood, MDDaisy Sahoo, PhDMichael Widlansky, MD Angelia Holtz (Conference Coordinator)

INTRODUCTION

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Bublr Bikes

MCW- Milwaukee c ampus has a Bub lr Bike sta tion and kiosk for those who want to use the b ike share p rogram to grab some exerc ise, c ommute or more effic iently get to their bus stop . The Bub lr Bike rac k is loc a ted just north of the Pub lic Sa fety offic e. Bub lr Bikes c an be c hec ked out with a c red it c a rd , the Bub lr Bike app , or with a Bub lr Bike key fob . They c an be c hec ked out a t any Bub lr Bike sta tion a round town and returned to any Bub lr Bike sta tion a round town.

Meet Our Sponsors

The p rojec t was supported by the Na tiona l Institutes of Hea lth, Award Number 1R13HL147501. The c ontent is solely the responsib ility of the author(s) and does not nec essarily rep resent the offic ia l views of the NIH.

MEET THE TEAM

Ramani Ramc handran, PhDProfessor, Department of Ped ia tric s and Clinic a l Transla tiona l Sc ienc e Institute Pa tric k J. and Margaret G. Mc Mahon Cha ir of Obstetric s and Gynec ologyVic e Cha ir for Researc h Obstetric s and Gynec ologyMed ic a l College of Wisc onsin

Lead Vasc ulata Organizing Committee Member - Dr. Ramani Ramc handran rec eived his BS and MS degrees from the University of Mumba i, Ind ia , Ph.D. degree a t Augusta University, USA, and was a post-doc tora l fellow a t Beth Israel Deac oness Med ic a l Center, Harva rd Med ic a l Sc hool. Currently, Dr. Ramc handran is the Pa tric k J. and Margaret G. Mc Mahon Endowed Professor of Obstetric s and Gynec ology (OBGYN), Vic e Cha ir for Researc h in OBGYN and Professor in the Department of Ped ia tric s a t the Med ic a l College of Wisc onsin (MCW). He is a lso the Direc tor of the Developmenta l Vasc ula r Biology Program and Zebra fish Drug Sc reening Core a t the Child ren?s Hosp ita l of Wisc onsin and MCW. He is the rec ip ient of the Na tiona l Canc er Institute Sc hola r Award in 2001. He rec eived the 2013 Distinguished Alumnus Award from Augusta University. He serves on na tiona l and interna tiona l panels for g rant review, most notab ly the Na tiona l Institutes of Hea lth (NIH) where he served as a c harter member of the Vasc ula r Cell and Molec ula r Biology Study sec tion for six years. His researc h p rogram investiga tes fundamenta l questions rela ted to b lood vessel pa tterning, and utilizes human c ell c ulture, zebra fish, and mouse model systems. His labora tory is known for innova tive d isc overies in the vasc ula r b iology inc lud ing the identific a tion of long non-c od ing RNA. He c ontinues to exp lore these questions and is funded by NIH and grants from other agenc ies. He has pub lished over 70 papers in lead ing b iomed ic a l journa ls and has more than 20 years of experienc e in b iomed ic a l researc h. He is c onsidered an expert in vasc ula r b iology and d iseases a ffec ted by deregula ted vessels. Dr. Ramc handran c ollabora tes extensively with labs within and outside of the USA. He manages an ac tive p rogram a t MCW c omprised of post-doc tora l fellows, tec hnic ians, med ic a l students, g radua te students, fac ulty and sta ff, and is ac tively involved with tra ining the next genera tion of sc ientists.

MEET THE TEAM

Veronic a H. Flood, MD Assoc ia te Professor of Ped ia tric Hematology Assoc ia te Investiga tor, Blood Researc h Institute Med ic a l College of Wisc onsin

Vasc ulata Organizing Committee Member - Dr. Veronic a Flood is a ped ia tric hematolog ist and researc her a t the Med ic a l College of Wisc onsin. She is the Assoc ia te Direc tor for the Comprehensive Center for Bleed ing Disorders in Milwaukee, where she sees pa tients with Von Willeb rand d isease (VWD) and other b leed ing and c lotting d isorders. She a lso sees c hild ren admitted to the hematology servic e. Dr. Flood is a member of the VWD subc ommittee of Interna tiona l Soc iety on Thrombosis and Haemostasis (ISTH) and the Sc ientific and Standard iza tion Committee (SSC). She is the Vic e Cha ir of the Mentored Researc h Award Committee for the Hemostasis and Thrombosis Researc h Soc iety. Dr. Flood?s researc h interests inc lude the d iagnosis of VWD and the interac tion of von Willeb rand fac tor (VWF) with p la telets and vasc ula r c ollagens. Through the Zimmerman Program for the Molec ula r and Clinic a l Biology of VWD she has worked on assays of VWF func tion and the genetic s of VWF, pa rtic ula rly sequenc e va riants tha t a ffec t VWF func tiona l assay results. She has rec eived a grant from the Na tiona l Heart Lung and Blood Institute to investiga te VWF interac tions with type IV c ollagen and the impac t of these interac tions on hemostasis.

MEET THE TEAM

Daisy Sahoo, PhDProfessor, Med ic ine (Endoc rinology) Sec ondary Fac ulty in Bioc hemistry and Pharmac ology and Toxic ologyVic e Cha ir for Researc h, Division of Endoc rinology and Molec ula r Med ic ineMed ic a l College of Wisc onsin

Vasc ulata Organizing Committee Member - Dr. Sahoo is Professor and Vic e Cha ir for Researc h in the Department of Med ic ine (Division of Endoc rinology and Molec ula r Med ic ine) and holds sec ondary appointments in the Departments of Bioc hemistry and Pharmac ology/ Toxic ology. She is an ac tive member of MCW?s Card iovasc ula r Researc h Center. Dr. Sahoo has been interested in lipoprotein metabolism and a therosc lerosis sinc e ob ta ining her PhD in Bioc hemistry from the University of Alberta in Canada and pursuing post-doc tora l stud ies a t Stony Brook University in NY. Sinc e bec oming a fac ulty member a t MCW in 2007, Dr. Sahoo has been c ontinuously funded by the NIH to study HDL-c holesterol transport and HDL rec ep tor/ ligand interac tions. More rec ently, she has expanded her researc h interests outside of c a rd iovasc ula r d isease to study the role of sc avenger rec ep tors in d iabetes and obesity. Dr. Sahoo is ac tively engaged in the MCW c ommunity. She teac hes and tra ins both gradua te and med ic a l students, and takes p ride in her role as mentor to numerous students and junior fac ulty. On a na tiona l level, Dr. Sahoo serves as a reviewer for study sec tions of the Americ an Heart Assoc ia tion (AHA) and is c urrently a stand ing member of the pa rent c ommittee for Program Projec t Grants a t the NIH. She is involved with numerous leadership ac tivities inc lud ing Arteriosc lerosis, Thrombosis and Vasc ula r Biology (ATVB) Counc il of the AHA, served as Cha ir of the Women?s Leadership Committee and c urrently serving as Vic e Cha ir of the Irvine Page Award Committee. Dr. Sahoo?s sc ientific c ontributions to the field of vasc ula r b iology were rec ognized in 2017 with a ?Vasc ula r Biology Spec ia l Rec ognition Award? by the ATVB Counc il.

MEET THE TEAM

Mic hael E. Widlansky, MD, MPHProfessor, Med ic ine Med ic a l College of Wisc onsin

Vasc ulata Organizing Committee Member - Dr. Mic hael Wid lansky is a Professor of Med ic ine and Pharmac ology in the Division of Card iovasc ula r Med ic ine a t the Med ic a l College of Wisc onsin. He rec eived his undergradua te degree in c hemistry from Stanford University and earned his MD with d istinc tion from the University of Mic higan. He c omp leted his tra ining in Interna l Med ic ine a t Brigham and Women?s Hosp ita l in Boston. He c omp leted c linic a l and researc h fellowships in Card iovasc ula r Med ic ine a t Boston University. Dr. Wid lansky jo ined the fac ulty of the Med ic a l College of Wisc onsin in 2007, bec oming the c a rd iovasc ula r d ivision?s d irec tor for researc h in 2010 and the d irec tor of MCW?s Card iovasc ula r Diseases Fellowship tra ining p rogram in 2014. He was named Assoc ia te Chief of Ac ademic Affa irs for MCW?s Division of Card iovasc ula r Med ic ine in 2015. Dr. Wid lansky?s c linic a l foc i a re genera l inpa tient c a rd iovasc ula r med ic ine and ec hoc ard iography. His researc h has been c ontinuously funded by the NIH sinc e 2009. His p rogram foc uses on the mec hanisms of vasc ula r dysfunc tion in pa tients with d iabetes mellitus and c oronary a rtery d isease. Together with his c ollabora tors a t MCW, Dr. Wid lansky was the first to demonstra te tha t a p rob iotic intervention c ould improve vasc ula r endothelia l func tion in humans with c oronary a rtery d isease. In add ition, his c ollabora tive work was the first to desc ribe a c ritic a l role for mic roRNA 29 in regula ting vasc ula r endothelia l func tion in both hea lthy humans and humans with c a rd iometabolic d isease as well as to demonstra te a c entra l role for mitoc hondria l func tion and mitoc hondria l dynamic s p roteins in regula ting vasc ula r endothelia l func tion in humans with type 2 d iabetes.

KEY NOTE SPEAKERCurt D. Sigmund, PhD James J. Smith & Ca therine Welsc h Smith Cha ir of Physiology Cha ir, Department of Physiology Assoc ia te Direc tor, Card iovasc ula r Center Med ic a l College of Wisc onsin

performed molec ula r and physiolog ic a l stud ies examining some of the first transgenic mic e with genetic a ltera tions in the renin-ang iotensin system. In order to c ap ita lize on the power of genetic s and physiology, he ac c ep ted a fac ulty position in the Card iovasc ula r Researc h Center a t the University of Iowa in 1991. Dr. Sigmund rose through the ranks and p reviously served as the Roy J. Carver Cha ir of Hypertension Researc h, Cha ir of the Department of Pharmac ology, and found ing Direc tor of the UIHC Center for Hypertension Researc h in the Roy J. and Luc ille A. Carver College of Med ic ine a t the University of Iowa in Iowa City, IA. In January 2019, Dr. Sigmund moved to be the James J. Smith & Ca therine Welsc h Smith Cha ir of Physiology, Cha ir of the Department of Physiology, and Assoc ia te Direc tor of the Card iovasc ula r Center a t the Med ic a l College of Wisc onsin. Dr. Sigmund was an Assoc ia te Ed itor of the journa ls AJP: Endocrinology and Metabolism, Physiologica l Genomics and Hypertension, and was the Ed itor-in-Chief of the American Journa l of Physiology - Regula tory, Integra tive and Comparative Physiology. He was an elec ted c ounc ilor of the Americ an Physiolog ic a l Soc iety and served as a regula r member of the NHLBI Program Projec t Grant Review Committee, and c ha ired the c ommittee in 2013. He is c urrently the Cha ir of the Pub lic a tions Committee of the Americ an Physiolog ic a l Soc iety. Dr. Sigmund has been rec ognized with researc h awards from the Americ an Federa tion for Med ic a l Researc h and Americ an Soc iety of Hypertension. From the Americ an Physiolog ic a l Soc iety, he rec eived the Henry Pic kering Bowd itc h Award Lec ture in 2000, the Ernest H. Sta rling Distinguished Lec turer in 2011, the Distinguished Lec turer in Physiolog ic a l Genomic s in 2016, and the Carl J. Wiggers Award from the Card iovasc ula r Sec tion in 2018. He rec eived the Regents Award for Fac ulty Exc ellenc e, Board of Regents, Sta te of Iowa in 2013, and the Leadership in Researc h Award from Vic e-President for Researc h and Ec onomic Development a t the University of Iowa in 2017. He was the rec ip ient of the Inaugura l Vanc ouver 2010 Lec tureship from Hypertension Canada in 2015. From the Counc il on Hypertension of the Americ an Heart Assoc ia tion he rec eived the Arthur C. Corc oran Memoria l Lec ture Award in 2007, and the Exc ellenc e Award In Hypertension Researc h (sponsored by Novartis) in 2009.

Dr. Sigmund rec eived his undergradua te educ a tion a t the Sta te University of New York in Buffa lo, NY, and his PhD (1987) in Molec ula r and Cellula r Biology from the same institution. He was orig ina lly tra ined as a c lassic a l bac teria l genetic ist but rec ognized how new tools designed to manipula te the mammalian genome would p rovide a mec hanism to link genetic s and physiology. He sought postdoc tora l tra ining in this a rea under the mentorship of Kenneth W. Gross a t Roswell Park Canc er Institute and

Luisa Iruela-Arispe, PhD Distinguished Professor of Molec ula r, Cell and Developmenta l BiologyDirec tor, Molec ula r Biology Institute Cha ir, Molec ula r BiologyUniversity of Ca lifornia

Developmenta l Biology, Direc tor of the Molec ula r Biology Institute and Cha ir of its Interdepartmenta l Gradua te Program. For the last two dec ades her researc h has foc used in eluc ida ting the mec hanisms and signa ling pa thways tha t regula te the growth and homeostasis of b lood vessels. Her efforts c ontributed to the litera ture of extrac ellula r matrix p roteins as regula tors of ang iogenesis, b roadened knowledge on VEGF and Notc h signa ling , and eva lua ted the relevanc e of endothelia l-hematopoietic c ell interac tions, inc lud ing the first lineage trac ing demonstra tion tha t hematopoietic p rogenitors emerge from the endothelium (hemogenic endothelium). In a series of manusc rip ts, she a lso showed tha t spec ific extrac ellula r matrix p roteins c ould have overrid ing effec ts in tumor p rogression desp ite the p resenc e of strong onc ogenes d riving mammary tumors and went on to identify d isc rete doma ins responsib le for the anti-ang iogenic effec ts. The reasoning tha t the ?anti-ang iogenic doma ins? loc a ted in thrombospond in might a lso be p resent in other p roteins, led to the c loning and c harac teriza tion of the found ing members of the ADAMTS family, a group of meta lloenzymes tha t now enc ompasses 19 p roteases involved in p roteolysis and p roc essing of extrac ellula r matrix p roteins. In add ition, through endothelia l and smooth musc le c ell inac tiva tion of Jag1, her labora tory c la rified the vasc ula r roots for the c a rd iac (endothelia l ? rela ted ) and liver (smooth musc le c ell ? rela ted ) pa tholog ies in Alag ille syndrome. This work highlighted the essentia l role of heterotyp ic vasc ula r-pa renc hyma l interac tions in liver a rc hitec ture. Dr. Iruela -Arispe has organized severa l Gordon Conferenc es, Keystone meetings, Workshops, and was the organizer of the Interna tiona l Vasc ula r Biology meeting in 2010. She was a lso President of NAVBO and member of c ommittees in AHA, AACR and ASMB. Dr. Iruela -Arispe is an ac tive pa rtic ipant in peer-review being a member of severa l ed itoria l boards and grant reviews. More rec ently, she bec ame a member of the NHLBI Counc il and the NCI intramura l review board . Her c urrent researc h foc uses on endothelia l regenera tion, vasc ula r dementia , and vasc ula r ma lformations. She teac hes Cell Biology every year to juniors and seniors a t UCLA and mentorship of young sc ientists is her top passion.

Orig ina lly from Spa in, Dr. Luisa Iruela -Arispe rec eived her PhD degree from the University in Sao Paulo in Brazil and performed post-doc tora l tra ining a t the University of Washington in Sea ttle. As an independent investiga tor she was first Assistant Professor a t the Department of Pa thology, Harva rd Med ic a l Sc hool and subsequently reloc a ted to UCLA, her p resent ac ademic home. At UCLA, she is c urrently Distinguished Professor of Molec ula r Cell and

KEY NOTE SPEAKER

7:00-7:50 am Registration & Breakfast (provided) (Alumni Center)

Time Title Presenter

7:50 am Introduc tion to Vasc ula ta (Kerrigan Aud itorium)

Ramani Ramc handran, PhD Med ic a l College of Wisc onsin

7:55 am Welc ome remarks (Kerrigan Aud itorium)

Joseph Kersc hner, MD

Med ic a l College of Wisc onsin

Ivor Benjamin, MD

Med ic a l College of Wisc onsin

8:05 am Role of the RhoBTB1/ Cullin-3 in Vasc ula r Smooth Musc le (Kerrigan Aud itorium)

Curt Sigmund, PhD

Med ic a l College of Wisc onsin

LUNG SESSION (Kerrigan Aud itorium)

9:05 am Developmenta l and inflammatory d isorders of pulmonary c irc ula tion in c hild ren and adults

Girija Ganesh Konduri, MD

Disc ussant leader

Med ic a l College of Wisc onsin

Elizabeth Jac obs, MD

Disc ussant leader

Med ic a l College of Wisc onsin

9:35 am Pulmonary a rteriovenous ma lformations in c ongenita l heart d isease: a transla tiona l researc h perspec tive

Andrew Spearman, MD

Med ic a l College of Wisc onsin

10:05-10:25 am Coffee Break- Sponsered By ib id i - c ells in foc us

10:25 am Vasc ula r regression by irrad ia tion: Role of the Notc h Pa thway

Meetha Medhora, PhD

Med ic a l College of Wisc onsin

11:00 am Akt-med ia ted phosphoryla tion of the C-terminus doma in of Hsp70 regula tes the a lterna te b ind ing of OLA1 and CHIP to c ontrol the mitoc hondria l import of SOD2

Adeleye James Afolayan, MD

Med ic a l College of Wisc onsin

11:25 am Mec hanosensitive mec hanism of ang iogenesis and lung regenera tion

Akiko Mammoto MD, PhD

Med ic a l College of Wisc onsin

12:00-1:00 pm Lunc h (p rovided) (Alumni Center)

1:10-3:00 pm WORKSHOP SESSION A

3:00-5:00 pm POSTER SESSION A

AGENDAMonday, July 15, 2019

AGENDATuesday, July 16, 2019

7:00-7:50 am Registration & Breakfast (provided) (Alumni Center)

Time Title Presenter

7:50 am Welc ome remarks (Kerrigan Aud itorium)

Reza Shaker, MD

Clinic a l & Transla tiona l Sc ienc e Institute of Southeast Wisc onsin

HEART SESSION (Kerrigan Aud itorium)

8:00 am Take another little p iec e of my heart; sta rting with Lub-Dub

Joy Linc oln, PhD Disc ussant leader Med ic a l College of Wisc onsin

8:30 am Exp loiting na tura l va ria tion to understand mec hanisms of heart regenera tion

Mic haela Patterson, PhD

Med ic a l College of Wisc onsin

8:55 am DMD-c ard iac exosomes c ontribute to the pa thogenesis of DMD c ard iomyopa thy

Jennifer Strande, MD, PhD

Med ic a l College of Wisc onsin

9:20 am Endothelia l Heterogeneity in Vasc ula r Injury and Regenera tion

Jalees Rehman, MD

University of Illinois a t Chic ago

9:45 am Mitoc hondria and neointima formation Isabella Grumbac h, MD, PhD

University of Iowa Hea lth Care

10:15-10:35 am

Coffee Break- Sponsered By ib id i - c ells in foc us

BRAIN SESSION (Kerrigan Aud itorium)

10:35 am Hypertensive Cerebrovasc ula r Disease and Dementia Development: A Role for Minera loc ortic oid Rec ep tor Signa ling

Anne Dorranc e, PhD

Disc ussant leader

Mic higan Sta te University

11:05 am An isogenic model of the b lood-b ra in ba rrier from human p luripotent stem c ells

Sean P. Palec ek, PhD

University of Wisc onsin Mad ison

11:30 am Basa l c ell sp read ing p rec edes and enhanc es rosette formation in human p luripotent stem c ell-derived neura l p rogenitor c ells

Ken Taniguc hi, PhD

Med ic a l College of Wisc onsin

12:00-1:00 pm Lunc h (p rovided) (Alumni Center)

1:10-3:00 pm WORKSHOP SESSION B

3:00-5:00 pm POSTER SESSION B

AGENDAWednesday, July 17, 2019

7:00-7:50 am Registration & Breakfast (provided) (Alumni Center)

Time Title Presenter

7:50 am Welc ome remarks (Kerrigan Aud itorium)

Gilbert C. White, MD

Med ic a l College of Wisc onsin

RENAL SESSION (Kerrigan Aud itorium)

8:00 am Role of mTOR signa ling in experimenta l sa lt-induc ed hypertension and kidney injury

Allen Cowley, PhD Disc ussant leader Med ic a l College of Wisc onsin

8:30 am Consequenc es of impa ired autoregula tion of rena l b lood flow

Alison Kriegel, PhD

Med ic a l College of Wisc onsin

8:55 am Two-photon imaging of intrac ellula r Ca2+ hand ling in smooth musc le c ells of freshly isola ted a rteries

Alexander Starusc henko, PhD

Med ic a l College of Wisc onsin

9:20 am Role of p66Shc in Regula tion of Mic rovasc ula r Reac tivity of Rena l Blood Vessels

Andrey Sorokin, PhD

Med ic a l College of Wisc onsin

9:50-10:10 am Coffee Break- Sponsored By ib id i - c ells in foc us

BLOOD SESSION (Kerrigan Aud itorium)

10:10 am Endothelia l dysfunc tion: Mec hanistic underp innings and c ontributions to c a rd iovasc ula r d isease

Debra Newman, PhD Disc ussant leader Med ic a l College of Wisc onsin

10:40 am Anti-Canc er therapy induc ed mic rovasc ula r dysfunc tion ? role of mitoc hondria l DNA damage

Andreas Beyer, PhD Med ic a l College of Wisc onsin

11:05 am Endothelia l homeostasis c ontrol by sma ll GTPase Rap1

Magdalena Chrzanowska- Wodnic ka, PhD Med ic a l College of Wisc onsin

11:30 am Mec hanic a l and molec ula r mec hanisms of aortic remodeling in response to c oarc ta tion severity

John LaDisa, PhD

Marquette University and Med ic a l College of Wisc onsin

12:00-1:00 pm Lunc h (p rovided) (Alumni Center)

1:30-5:00 pm Boat Tour of Downtown Milwaukee and the shoreline of Lake Mic higan The c ost of the tour inc luding transportation to and from the boat tour is provided

*details on next page

5:30-7:30 pm Rec eption Dinner (HUB 1st Floor) Veronic a Flood, MD Mic hael Widlansky, MD Med ic a l College of Wisc onsin

AGENDAThursday, July 18, 2019

7:00-7:55 am Breakfast (provided)

Time Title Presenter

8:00 am On the pa th of Vasc ula r Regenera tion (Kerrigan Aud itorium)

Luisa Iruela-Arispe, PhD University of Ca lifornia , Los Angeles

9:00-9:20 am Break

9:30-11:00 am Ta lks selec ted from abstrac ts (Kerrigan Aud itorium)

11:00 am Conc lud ing remarks (Kerrigan Aud itorium)

Daisy Sahoo, PhD Med ic a l College of Wisc onsin

Boat Tour of Downtown Milwaukee

and the shoreline of Lake Mic higan

Wednesday, July 17, 2019 1:30-5:00 pm

A priva te c ruise will travel through downtown a rea via the Milwaukee River and into Lake Mic higan. The vessel will rema in inside of the b reakwater a long the shoreline of Lake Mic higan, p rovid ing the best views of the c itysc ape.

Some key highlights and a rc hitec tura l treasures tha t will be seen a long the way inc lude the Historic Third Ward , the Marc us Center for the Performing Arts, City Ha ll, The Allen Brad ley c loc k tower, the Milwaukee Art Museum, Disc overy World a t Pier Wisc onsin, Henry Ma ier Festiva l Grounds (Summerfest) as well as the development and revita liza tion a long the riverfront.

WELCOME REMARKSJoseph E. Kersc hner, MD Dean of the Sc hool of Med ic ine Provost and Exec utive Vic e President Med ic a l College of Wisc onsin

Ivor J. Benjamin, MD, FAHA, FACC Direc tor, Card iovasc ula r Center Professor of Med ic ine, Physiology Pharmac ology & Toxic ology Cell Biology and Surgery Med ic a l College of Wisc onsin

Reza Shaker, MD Joseph E. Geenen Professor and Chief, Division of Gastroenterology and Hepa tology Direc tor, Digestive Disease Center Assoc ia te Provost, Clinic a l and Transla tiona l Researc h Senior Assoc ia te Dean and Direc tor Clinic a l and Transla tiona l Sc ienc e Institute Med ic a l College of Wisc onsin

Gilbert C. White, II, MD Exec utive Vic e President for Researc h, Versiti Professor Department of Med ic ine, Bioc hemistryPharmac ology & Toxic ology Med ic a l College of Wisc onsin

Robert H. Lane, MD Assoc ia te Dean for Researc h, Med ic a l College of Wisc onsin andChild ren's Hosp ita l of Wisc onsin Assoc ia te Direc tor, Ep igenomic s, Genomic Sc ienc es and Prec isionMed ic ine Center Professor and Cha ir, Ped ia tric s Ped ia tric ian in Chief, The Barri L. and David J. Drury Cha ir inPed ia tric s, Child ren's Hosp ita l of Wisc onsin