Vancomycin hydrochloride Chemical structure (Chemical Structure):

Title: Synthesis of vancomycin from the aglycon Of: Thompson, C.; et al. Source: J Am Chem Soc 1999,121 (6), 1237

Synthetic routes illustrate: A formal total synthesis of vancomycin has been reported. The known aglycon of vancomycin (I) was protected at the amino group as the allyloxy-carbonyl derivative (III) using allyloxycarbonyl succinimide (II). Then, carboxylate group was converted to allyl ester ( V) with allyl bromide (IV) and KHCO3.