US Food and Drug Administration: 2007-4301t1-Index

8/14/2019 US Food and Drug Administration: 2007-4301t1-Index

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Page 1

A

abandon 203:21

abandons 245:6

abbreviated 30:15

ability 57:11 248:22

325:17ablates 192:10

ablative 315:5

able 34:18 50:21 65:17

128:19 138:4,7,21

139:16 140:1 143:21

155:15 203:2 220:16

266:15 282:13 284:2

289:3 293:11,16,21

297:8,10,16 309:6

321:17 330:5

abnormal 68:14 220:5

220:7 239:4,15 316:6

abnormalities 219:6

250:14

Abramson 4:13

abrogation 196:7

abruptly 20:5

absence 48:16 98:20

99:2 199:14

absolute 225:9

absolutely 151:20

152:13 161:19 169:6

271:10 288:10,22

absorbed 271:12,19

absorption 270:17,21271:8,18 274:9

accelerated 51:1,21

113:6 267:18 330:3

accept 156:9,13

acceptable 43:17 54:2

59:15 116:8 156:10

156:11 162:6,7

236:22 238:2 268:18

accepted 166:9

access 17:20 56:3

57:10 108:11 183:16

308:19accommodate 89:21

240:7

accompanied 224:9

account 112:4 257:20

accounted 40:22 41:3

120:2,6 125:14

129:14

accounts 148:3 332:5

accrual 67:12 70:8

107:18 172:1 309:16

321:3 327:11

accrued 70:10

accuracy 76:18accurate 175:14

ache 288:10 290:7

achievable 142:22

143:6

achieve 188:17 214:19

324:18,19 328:10

achieved 211:21 214:6

325:1

aching 147:7

acid 273:3

acquire 108:10

acquired 20:7,8 61:5,6

186:11Act 59:9

ACTH 220:12 298:4

ACTH-stimulation238:18

acting 182:8

action 52:18 154:18

activated 33:18

activation 31:3,7,9

active 24:21 29:18 30:7

30:12 31:1 63:22

66:13 73:4 84:13

186:13 192:18 197:4255:9 271:11 272:21

274:2,19 283:1

actively 122:1

activities 147:6 282:22

activity 26:11 31:4

33:19 34:14 53:13

54:4 85:20 97:10

101:2 165:11 166:14

256:11

acts 30:1

actual 93:3 97:11

250:19 269:22 316:7

acute 184:19 185:5,11

189:15 193:1 200:14

214:2,4 222:21 249:5

267:15 292:20 293:5

294:15 296:3,16

298:18 326:12,14

Adamson 4:10 13:16

13:16 17:9 102:8,9

105:1 124:6,7 162:17

162:18 163:11

175:11 179:15,15

adapting 56:5

add 109:17 111:22

236:10 246:16298:14 323:11

added 134:1 204:10

216:1 298:11

adding 24:17 28:13

42:7 43:19 111:14,17

160:10

addition 21:16 23:21

35:18 44:8 55:8

101:6 103:22 150:13

168:7 235:11 258:20

327:21

additional 20:17 27:5

40:21 41:6 55:1963:13,20 64:18 71:21

72:2 76:7,16,22 77:1

81:22 92:14 94:8,9

108:2,3 120:8,15

123:9,20 125:5,10

130:10 142:13

144:15 160:7 171:10

173:17 200:20

201:17 204:2 205:16

214:10 215:17

239:17 330:11

Additionally 81:8address 18:7 22:17

23:8 44:12 90:10

91:2,6 112:19,20

119:3,4 136:12 155:3

184:3 231:11 252:9

254:11 258:4 275:22

276:9 315:12 316:10

316:17 320:5 325:4

addressed 24:10 90:13

101:7 114:5 126:17

addresses 16:4 182:16

224:5 225:11

addressing 23:4 45:1

adds 28:11,13

adequacy 165:6

adequate 59:12,13

67:19 72:18 170:10

170:16 304:11,17

adequately 311:5

adjourn 12:16 180:4

261:1 333:5

adjourned 333:7

adjusted 48:2 207:21

adjustment 207:13,14

237:13

adjuvant 26:12 150:13administer 70:1

administered 19:17

54:7 238:18 282:1

administering 253:2

administration 1:1

6:11 7:1 8:10 30:18

31:6,10 135:14

232:15 275:2

admission 291:17

316:20

admittedly 177:18

325:22

adolescent 8:16 22:6adolescents 60:8

adrenal 195:6 219:16

220:1,3,5,9,12,15

250:15 298:5

adriamycin 161:14

adult 56:6 116:14

134:9 277:2 278:16

adults 18:18 32:15

39:14 53:10 118:17

131:4 208:3 290:14

advance 43:21 164:17

164:19,21advanced 208:16

advances 191:12

230:17

advancing 19:7

advantage 38:14 41:9

57:14 203:20 252:6

313:7 330:18

advantages 331:1

adverse 43:12 85:10,17

85:21 86:6,8,10 87:1

87:3 198:9,11 201:19

206:9 218:11,17

219:10,15 223:10,20

224:1 226:18 241:21

258:12,16 315:10,15

316:3

advise 136:1,10 138:9

275:11,20 321:8

advised 148:18

advising 116:5





Page 2

advisor 185:14

advisors 8:9 185:20

advisory 1:5 2:3 3:1

52:11 135:18 141:1

144:5,14 275:6

317:16advocates 140:14

ad-hoc 311:20

AE 221:10

AEs 218:14 220:19

Affairs 4:5 15:11

affect 126:3 154:19

176:20 214:13

affiliations 180:20

affinity 273:7,8,10

274:3

afraid 144:3 281:14

afternoon 6:2 7:10,16

180:14,15 184:13225:20 276:6

age 24:22 25:3 34:22

37:20 38:19 67:17

208:16 216:9 244:17

254:22 255:1,1,6,18

256:11,11 278:19

281:17 288:4

Agency 212:22 213:16

234:11 323:1

Agency’s 17:15 183:11

agenda 13:7 16:7 18:1

182:19 183:19 185:1239:22 303:11

agent 13:8 54:17 56:7

57:10 61:5,6 64:1

66:13 78:1 97:8

101:3 114:14 143:3

151:18 166:7,8,14

180:16 245:10

296:11 297:19

303:21 310:6 329:3

agents 19:19 26:11,12

29:9,18 56:3,4 96:11

98:15 151:12 177:15

aggregate 123:4,5

aggressive 148:11

aggressiveness 154:19

ago 147:12 161:18

166:12 172:1 194:20

195:7 197:12 198:1

223:15 254:21

255:16 272:19 288:2

291:7 302:7 330:14

agree 106:21 107:7

141:20 152:10

161:13 165:7,22

167:2 189:10 245:6

245:12 246:4 251:4315:2 327:8 332:14

332:17

agreed 40:3 44:22

139:9

agreement 190:10

agrees 231:16

ahead 167:1 171:14

175:9 254:18 318:7

aid 207:19

aim 36:13,17 50:17

al 274:6 295:1

aligning 268:5

alive 83:21 84:5 100:17125:11 129:9 153:2

172:5 174:18,22

214:5 216:21 283:18

allagraft 231:1

allege 271:2

allergy 87:18

alleviate 290:16

allocated 27:2 233:12

237:8

allogeneic 184:21

190:15 191:6 199:9

279:7allograft 228:6,14

254:22 255:18

allografts 255:6

allow 30:4 195:5

255:16 256:18

allowed 143:7

allowing 51:2 184:18

allows 307:20

alluded 257:2 280:6

alpha 51:8 52:1 81:21

82:11,20 89:8 113:11

114:6 242:4

Alsante 140:10,11,12

145:4

alterations 99:11

alternative 66:2 78:9

307:17 311:18,19

alternatives 138:3

ambitious 143:20

amended 59:10 206:22

amendment 81:19

229:12

America 140:13

American 34:17

AML 73:4 316:19

amount 63:22 151:16195:17 220:14

250:10 258:10

amplified 323:4

amputated 137:21

138:1,2,9,11

amputation 150:9

analog 29:20

analyses 20:18 21:13

21:17 36:9 38:17,18

39:20 40:14 42:3

45:17 69:5,6 75:17

81:16,22 82:1,9 83:5

106:1 113:21 124:9132:19 207:19

214:11 215:2 221:21

230:3 232:6,8 233:15

233:16 234:4 236:12

238:21 242:16

analysis 20:15 28:3,18

34:21 35:6 36:10,17

37:12,13,14 38:5,15

38:15 39:18,18 41:3

41:8,19,20 42:1 45:3

45:5,11,13,18,20,21

45:22 46:4,5,7 47:1649:5 50:14 52:1,2

54:20 59:7 64:21

65:5,13 66:6,16 67:8

68:5,18,20 69:4

70:11,17 75:8,14

76:1,4 77:15 78:5,6

78:13 80:4,6,9,9,11

80:12,17,19 81:10,11

81:13,20 82:3,4,7,8

82:11,13,21 83:3,14

83:18 88:8,13,14,17

89:11 97:2,20 102:12

102:22 103:7,22

104:2,9 105:5 106:4

106:5,17 108:8

110:10,12,18 113:13

113:15,18 114:1,2

118:5 124:15,17,20

124:22 125:13,19

127:11,15 129:22

131:19 132:2,3,11,21

133:2,4,6,9,10 157:5

157:10,20 160:19

164:2 165:14 168:15

171:3 173:4 175:14

176:2,3 202:4,7,8,9202:12 206:22 207:1

207:5,15 213:1,19

214:12 215:18

216:18 217:9,11,19

219:2 221:16 223:14

226:6 231:5,16 232:4

233:10 234:2,6,8

236:18 237:9,12

239:3 244:7 251:5

257:9 262:1,19

268:10,20 305:4

324:18 325:8

analytic 36:12analyze 66:3 78:10

89:7 104:17 265:3

analyzed 20:12 36:19

67:6,14 72:15 117:13

249:16

analyzing 20:6 78:15

ancillary 270:19

Anderson 4:6 9:5 14:2

22:20 33:7 52:13

116:15 139:2,3

145:19 149:2,15

181:7anecdotal 93:7

anemia 288:3

Angela 5:15 13:18

angry 280:11 286:17

animal 196:21

ankle 277:18

Ann 7:17 182:7 299:13

300:14 332:2

Anna 291:3 295:13

announcement 16:3

182:15 261:5

annually 187:17

anorectic 248:3 249:9

anorexia 199:11 235:6

312:3

answer 23:5 35:9,20

66:8 91:5 99:20

102:20 105:20 108:4

110:8 111:10 114:16

117:19 124:18 155:6





Page 3

162:8 169:17 171:22

176:6,7 243:17

259:14 262:16

264:12,14,16 265:13

268:8 284:6 301:22

302:1,4,5 307:5320:1

answered 129:21

134:22 173:6,7

330:12

answering 21:8

answers 15:21 90:9

169:8,8 307:4

antibiotics 137:11,12

antigenemia 221:3

antigens 196:8 221:5

antiinflammatory186:15

anti-cancer 19:19anti-leukemia 193:19

anxiety 198:14

anybody 118:1 154:7

301:14 305:13

anytime 193:2

anyway 172:11 318:2

anyways 292:17 294:2

apologize 303:8,9

332:6

apparent 20:16 41:20

42:19 43:1 46:20

216:8apparently 25:12

87:18 142:4 284:4

appear 39:1 110:21

121:17,17 145:11

152:15 193:2,21

198:22

appearance 16:5,11

182:17 183:1 193:4

appeared 161:6 162:2

199:5 212:20

appears 47:3 102:6

128:12 176:14

196:20 250:11

264:10 298:3,12,17

appetite 194:12 282:2

applaud 29:1 142:4

Applause 140:8

Applicant 58:17 73:1

78:17 228:21 238:7

Applicant’s 75:8,14

77:14 78:15 81:9

application 58:10,18

59:6,8,17 60:3 61:8

61:16 70:13 73:3,10

74:6 88:17 89:2

155:21 176:20 177:9187:18 188:7,8

applications 70:16

186:17

applied 130:21 272:14

apply 89:9 141:14

177:20

applying 75:14 81:9

appreciably 33:14

appreciate 102:12

139:22 313:18

approach 32:1 37:12

47:13,15 51:2 60:15

104:17 131:16 157:6157:21 162:22

230:11 310:21 311:1

312:5,8

approached 33:3

approaches 165:20

approaching 55:13

appropriate 49:9 68:13

72:12 75:9 77:15

80:19 88:7 110:11

125:12 178:9 267:3

307:8

appropriately 171:1305:2 307:6

appropriateness 20:18

approvable 204:21

approval 34:9 36:4

51:1,3,4,7,21,22

56:17 58:22 67:20

68:14 113:6 142:5,7

142:10,12 143:3

144:20 159:8 180:2

188:19 325:20 330:3

approvals 141:18

144:19

approve 158:11 160:1

294:6 307:15 309:11

317:13,15 326:8

approved 56:14 57:6

111:13 114:9 166:16

197:11,14 253:8

306:9 318:2

approving 294:6

306:15,16

approximately 25:2,14

28:17 60:9,10 65:2

82:6 84:20 116:21

150:10,15 160:9

191:5 298:2approximates 312:5

April 77:11 82:12

123:13

arbitrarily 204:6

322:17

arbitrary 233:19 323:8

Arbor 299:13 300:14

332:2

Architecture 9:2

area 319:22

areas 25:10 316:9

aren’t 129:1 142:1

167:10 305:21 327:9arguably 264:7

argue 278:16 310:17

321:20

argument 89:1 241:8

246:5 250:7,17 315:8

arising 25:6

arm 33:11 35:13 60:22

61:1 63:5 64:1 65:15

65:16 67:2,3 75:10

77:16,19,20 79:19

80:7 88:5,6,9,10

96:11,12,16,18 97:697:12,17,18 98:14

101:6 104:18,19

105:10 109:6,15,17

109:18 116:7,7,8

117:22 119:1 125:6,9

133:17,18 147:22

161:6 162:1 168:17

202:5,5,18 209:10,11

210:2,3 212:2,3,7,7

213:5,5,9,10,21,21

217:1 219:14,14,19

219:20 220:11,18,21

221:1,4 236:20,20

237:17,17,21 239:1

241:2,10,14 250:13

250:15 251:1,1 257:4

266:1 310:12,15

314:20,21 315:16

321:19

armed 287:1

arms 35:22 36:1 38:3,4

43:7 47:15 48:1

65:13,18 66:2 70:3

73:6,18 77:19,22

78:9 81:6 86:9,12

87:2,4,8,8,15 88:7,1197:4,13 101:1,4,5

104:18 105:15

109:21 110:9,19

117:22 119:16 125:6

154:14 174:1,1,5,7,8

177:8 178:12 227:8

232:18 237:20

238:17 239:13 241:9

250:11,21 321:1

325:14

arrived 164:11

arsenal 189:12 278:6

art 181:21 281:4ARTHUR 6:9

article 109:12 325:20

ascertain 44:19

ascertainment 110:15

112:5 131:5 176:9,10

ASCO 28:8

aside 106:13

asked 28:3 44:18

103:13 123:10 141:5

155:7,8,17 157:4

159:7 162:20 212:22

253:3 293:1 294:19322:1 331:19

asking 89:15 165:4

240:4 253:12

aspect 148:1

aspects 153:3

aspergillosis196:14

assembling 143:17

assess 35:21 47:14

50:19,20 200:21

214:12

assessed 36:6 46:9 48:1

assessing 272:21

assessment39:4 53:18

100:14 124:2,3 185:6

188:3 200:6

assets 20:7 108:11

assigned 85:16 209:4

assignment 67:11

216:15

assignments 73:13





Page 4

Associate 3:10

associated 24:14 28:14

43:10,12 53:20,21

54:9 85:17 87:6

221:19 222:19

229:13association 300:16

assume 55:17 111:14

125:12 248:4,7

308:17 314:2 320:20

320:22 330:11

assumed 36:19 125:20

125:20 172:7

assuming 65:10 125:13

131:21

assumption 176:1

assumptions 320:14,18

320:19

assurance 95:17,18assure 153:19

assured 93:7

assuring 46:1

asthma 200:14

asynchronous 95:21

118:7,8

asynchrony 91:17 92:3

92:9

ATG 292:7 298:13

athletically 283:1

attack 190:16 200:14

attacked 279:14attacks 292:21

attaining 60:17

attempt 155:18 227:2

267:13

attempted 97:13

attempting 130:9

320:5

attempts 177:7

attend 149:17 281:18

293:22

attendance 136:7

275:17

attending 201:16

215:16 249:21

252:13

attention 140:16 218:3

238:4 239:19 279:5

attractive 327:6

attributable 250:12

attributed 147:7

attributes 198:14

attribution 85:16

AUC 273:15

audience 303:17

audit 93:15,16,19,21

94:5audited 37:3 92:11

auditing 92:13

augmented 233:7

August 40:8 94:20

139:11 279:7 293:16

Austin 181:22

Australia 138:4,6,7,13

Australian 138:16

aux 263:12

availability 69:22

available 17:18,20

20:22 23:5 27:13

28:21 29:4,11 57:582:12 94:6 106:3

108:14,18 118:18

122:16 142:18,18

152:20 183:14,16

253:4 288:12 292:10

306:12 311:15

329:15 330:5

average 46:19 105:14

160:13 211:12

248:15 288:4 289:14

avoid 53:17 170:5

224:15avoidable 57:8

avoidance 224:8,11

247:7

avoided 224:1

avoiding 201:7 211:22

246:21 247:10

awaited 138:13

aware 18:3 183:21

283:18 292:3

awful 224:14 247:6

249:22 278:7

axis 195:6 210:22

219:21 220:1,3,5,15

223:12 226:19

229:13 271:8,13,16

A-F-T-E-R-N-O-O-N180:10

A-minus 35:14 36:1

38:3 48:6 97:15 98:2

104:18 109:13

111:22

A-plus 35:22 38:4

42:20 107:8 110:22

112:7,9 129:4 157:1

160:20

a.m 1:8 13:2 287:8

B

b 12:4 35:22 45:9 47:1

47:10 48:3,21 63:4

63:17,19,22 64:2

65:16 66:14,19 67:1

73:19,21 78:19,19

79:5,5,12,13,18,21

80:1,5,8 81:3,4 88:5

90:16,19 96:11,12

97:18 101:6,16,18

102:1 127:3,14,14,15

128:9 156:22 160:9235:4

back 49:4 90:12 103:15

118:19 124:7 128:20

135:7 148:15 154:11

159:6 165:5 175:12

195:16 200:7,8

209:21 211:15

224:11 249:6 250:16

253:11 261:2,12

263:7 270:9 285:9

286:12 291:7 303:16

304:5 311:6,14315:18 319:22 325:6

background 11:17

59:1 65:21 117:15,17

184:10 300:15

bacteremia 219:13

314:21

bacterial 29:22 221:7

bad 138:17 243:15

254:1 265:22 272:12

285:4

badly 285:14

baggage 280:5

bags 149:8bail 250:1

balance 57:21 112:6

248:19 267:14,22

306:14

balanced 43:7 54:5

202:19 226:21

ball 290:2,3

BALLROOM 1:12

bar 142:2 143:18

144:22 307:1,1

312:15 316:18 317:2

bare 142:2 144:21

barely 289:3bargain 283:8

barium 194:3

barring 330:22 331:2

base 160:14,17 261:8

baseball 289:8

based 16:7 33:4 38:6

38:15,18 41:14 44:1

45:3 51:3,4 56:17

57:15 58:18 60:3

62:15 69:11 70:20

71:18 77:5,10 79:11

80:15 82:2,7,13

83:12 88:16 92:393:4,15 106:2 108:5

115:2 116:18 129:14

132:3 142:12 143:4

144:20 151:20 157:6

167:4 169:6 182:19

188:19 191:3 227:20

232:14 233:18 234:2

248:17 271:19

303:22 323:14 326:8

baseline 171:2 199:15

206:21 214:15

215:18 220:5 226:21228:15 238:19,19

239:4 244:17,19

258:6 267:12,14

305:3

bases 289:15

basic 146:11,22

basically 107:8 133:16

253:13 281:20 282:3

292:22 293:7

basis 21:1 34:9,14 36:3

209:4 219:2 282:14

bat 289:19

bathroom 287:9 290:4

battle 144:8 150:2

BDP 186:19,19 187:7,8

188:11 189:4 196:18

198:5 200:10,20

201:7 202:5,18,21

208:2,9,12 209:11,20

210:2,8,10 211:2,6





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211:16 212:3,7 213:5

213:10,21 214:16

215:4,6,13,13,19,21

216:2,5,8,21 217:14

217:20 218:13,18,22

219:5,12,14,19 220:7220:11,14,20,22

221:9,15 222:3,14,22

223:2,10,11,17 224:5

225:10 227:9 231:20

232:18 233:17

236:20 237:5,16,21

239:1 241:2,10,14,22

244:14 248:9 249:15

250:13,15 257:8

260:11,12 262:3,14

263:5 266:1,10

270:11 272:8,14,17

272:19 273:3,3,5,7274:8,13 294:16,20

296:16 311:1,5 313:8

314:20,21 315:3,15

bears 310:12

beat 149:3

beautiful 153:9 284:15

288:15

beclomathasone185:10 186:14,19

198:21 200:16 252:3

beclomethasone 185:2

252:15 253:6 291:6293:1,8,11,14 295:1

bed 285:4 286:5

bedridden 281:20

285:13

bedside 278:3

began 187:8 322:20

330:14

begging 290:8

beginning 70:1 84:22

135:22 136:10,13

156:3 275:10,20

276:1 278:19 281:20

begun 201:1

behalf 9:6 41:22

153:18 184:16

behavior 265:4

Bekele 9:13 125:15,18

believe 57:16 98:11

102:3 110:3 111:16

116:5 132:2 135:15

140:5 164:10 168:13

169:16 188:19

239:17 245:14

259:13 271:10 275:2

299:10

believes 135:18 275:6benchmark 144:21

benchmarks 141:22,22

142:1

bending 282:21

beneficial 238:13

benefit 22:21 27:5

36:14 40:2,5 41:16

41:18 42:5 51:5,14

52:6 54:1,18 55:11

55:21 59:20 109:17

110:19 112:6,9 140:5

161:21 170:2,20

175:15 176:12,12,13178:4,7 198:7,8

224:7,16,17,17 244:3

246:21 247:9 253:14

254:2,8 255:22 256:3

256:19 257:17

261:18 263:14,15

264:17,19 266:16

304:20 305:18

309:11 310:18

317:12,17

benefits 20:9,16 21:16

22:3 53:19 57:22188:20 197:22 246:6

283:5 330:22

benefitted 262:4,6,14

benefit/risk 10:20 52:8

53:18 185:6 223:14

benign 280:5

best 31:21 85:18 98:6

98:21 117:7,9,20

163:1,4,5 167:3,14

167:15 171:17

317:11

better 33:14 50:12

53:13 115:14 133:21

134:11 139:10

161:11 198:17

214:19 224:2 225:11

231:21 248:22 250:7

260:13 272:11,15

288:11,12 290:15

291:6 306:4 307:14

312:19 315:5 324:22

between-arm 155:15

155:20

beyond 32:17,19 94:8

130:2 133:1,12 214:1

251:14 277:8bias 112:5 171:2 234:1

305:3 316:8

biased 83:13

biases 119:1 176:9

big 158:15 159:17

165:1 317:20 328:6

bigger 306:22

biggest 328:22

binding 273:8,9

Bio 11:16 180:17

184:15 186:6,12

190:7 244:11 278:11

328:2biochemical 220:2,17

223:12

bioequivalence 228:22

Bioinformatics 5:9

biologic 6:19,22 33:19

53:12 54:3,11 64:11

85:20 150:3 265:4

biological 64:9,15

114:20 115:3

biologically 153:2

169:5

Biologics 144:6biology 2:16 52:15

145:18 214:7 295:3

biopharmaceutical186:6

biopsy 62:22 67:18

137:17 147:15

199:15

biopsy-proven 199:12

biostatistician 14:15

biostatisticians 156:7

Biostatistics 2:15 5:7,8

7:6,9 8:5

biotech 20:4

Biotherapy 20:3

bit 127:16 190:11

193:8 194:2 225:2

242:4 245:5 270:14

291:5,5 315:11 316:9

black 31:18

Blaney 4:14 15:7,9

134:20,22 166:22,22

167:1,2,17 179:17,18

179:19

blinded 69:12 187:13

188:12

blonde 284:15 288:15blood 208:22 216:10

228:7 231:1 276:6,11

276:18 288:4 295:3

302:20 309:19

315:19,20

bloodstream 273:12,18

273:21 274:12

blue 33:13

Blumenstein 9:1 10:19

22:15 44:12,15 97:22

102:15,21 104:4

105:6 106:20 107:2

113:2,3 127:17,20128:2,10

BLUMENTHAL104:8

blunt 298:5

BMC 294:19

BMT 276:12 279:9

board 167:20

Bob 278:1

body 141:17 281:21

285:7

bone 18:18 24:21 25:2

25:9,10,11 60:767:18 137:10 150:6

208:20 216:9 231:2

245:1 259:10 261:17

270:1 276:17 278:21

279:1 288:1 293:21

325:18

bones 25:5 282:20

292:3

Bonnie 8:13 10:10,15

18:21

bony 67:22

book 123:3,6

boss 331:22 332:20

Boston 5:5 14:15 129:5

bothered 161:5 172:10

173:7 266:10

bothersome 87:22

172:8

bottom 66:20 79:12

163:16 295:16





Page 6

297:13 317:7

bowel 199:4 253:8

289:5 326:1

bowels 279:15

boxes 39:1

boy 288:15BP 306:13

Branch 6:6 146:3

168:1

brave 290:13

bravely 284:16

break 131:9 303:17

breaking 135:6

breaks 289:22

breathe 285:19

Brent 9:1 10:19 22:15

44:11

brief 78:14 89:20

105:19 131:9,11185:1 192:8 240:6

briefing 45:2 174:14

174:14 186:9 202:11

207:10 314:19

briefly 22:10 59:1

84:19 95:3 156:16

226:7 314:7 315:9

bring 20:21 193:18

bringing 331:3

brings 153:22

Britain 97:1

British 274:6broke 288:19

bronchiolitis 221:13

brother 152:7 279:9

281:17

brought 270:18 280:16

329:14 330:17

332:18

brown 31:18

budesonide 197:12

253:7 270:18,21

311:22

Buffalo 294:21

build 169:7

Building 17:17 183:13

bully 332:10

bump 195:16

burden 24:18 28:14

151:15 195:17

burial 148:19

burning 154:7 318:6

business 57:3

busy 323:22

buying 315:1,7

Bye-bye 294:7

B-minus 35:14 36:1

38:3 48:6 97:15,2198:2

B-plus 38:4 42:20 48:4

156:22

C

c 2:1 11:1 12:1 229:3

235:5

calcineurin 192:14,15

192:17 193:15 296:6

calcium 219:7

calculate 71:15 201:12

203:19

calculations 62:14California 14:5 181:9

call 10:5 11:10 13:3

180:12 218:3 221:11

240:5 282:10 311:19

called 142:10 180:17

276:11 302:21

caloric 201:13,15

203:3,16,19 227:13

228:16 229:21 235:6

248:13,14 249:7,19

canceling 260:20

cancer 2:17 3:12,17,224:6,16,21,22 6:7,8

8:22 9:5 13:15 14:1,3

14:13 18:18,20 19:5

20:1 21:5 22:12,20

24:2,10 25:2 28:22

29:6 32:11,14 35:8

51:2 52:13,15 56:15

60:8 62:4 139:8,12

139:19 141:15,18

143:5,11 144:10,16

144:19 145:18,19

146:4 148:8 168:2

181:5,7,17,19 185:9185:21 186:2,8 187:9

252:11 293:20 320:9

cancers 24:8 27:21

140:17 141:3

can’t 105:4 117:10

121:9 132:1 158:9,15

163:17 164:20

249:10 257:5 259:14

259:15 278:3 285:6

285:14 295:19

312:11,12 316:10

321:20 327:17 329:4

cap 133:11capacity 146:21 277:15

289:16

capricious 242:15

capsule 197:13 229:4

295:17

capsules 228:21 293:8

295:22

capture 69:13,20 72:19

203:14 254:18

captured 69:18 72:14

76:10 203:15 233:22

carbohydrates 282:3

carcinoma 314:2,9cardiac 67:19 68:14

care 13:9 26:17 35:15

59:2 75:11 77:17,21

81:7 96:19 97:1

98:17 112:13,13

116:13 134:12 139:3

161:4,16 166:9,17

170:5 201:4 225:3

230:17 234:16

288:17 311:2 312:6

carefully 26:8 219:5

carried 26:20 29:369:14 74:18 99:22

199:5

carries 192:2

cars 282:21

cascade 31:5,7

case 37:2 45:11 66:3,17

69:13 70:21,22 76:10

76:11,12,16 77:1,2,5

78:10 90:21 91:13,17

92:3 94:15,17,18

95:12,13 118:7,9,10

122:1,7,15,17 142:14

143:19 144:11 158:6

160:15 172:12

175:18 221:8,9

242:14 262:8 265:18

cases 60:9 71:11,13

122:4 170:22 195:10

251:14,15 277:15

305:1 330:17

CAT 69:16

catch 89:16 240:4

category 249:4

caught 144:13

cause 115:15 159:6

184:20 195:21229:17 249:21

264:22 298:15

caused 54:14 95:22

150:11 156:14

285:16 286:17

causes 32:16 212:6,8

213:11,20,22 223:1

causing 87:11 192:4

CBER 144:14

CCG 61:21 62:5,11

67:4 78:5 85:12

CDER 1:2 6:16,19,22

7:6,9,12,14,19,22 8:28:5 144:14

CD4 196:2

CD8 196:2

ceiling 133:7,11

celebrating 288:15

cell 29:22 184:22 196:8

216:9 247:2 276:18

291:7 314:1,8

cells 31:13,17,17

190:17 192:12

208:21,22 216:10

228:7 231:1 244:18259:10

center 1:2 3:10,12,13

3:17,22 4:6,13,16,21

5:9 6:7 8:22 9:5

13:14 14:3,13 16:10

22:12,20 32:12 52:13

144:6 145:19 181:7

181:17 182:22 185:9

185:21 186:2,5

187:10 193:16

205:19,20,20 206:17

209:4 216:10,12

227:7 228:14 235:4

248:12 252:11,12

253:7 284:17 293:20

312:1 320:9 323:22

centers 69:17 195:9

203:18 204:13

216:12 252:4

central 37:4 40:7 69:12





Page 7

95:8

certain 163:15 165:12

226:17 320:18

certainly 97:7 99:10

121:3 161:10 162:18

165:19 192:22251:19 271:12

282:17 284:6 312:14

317:6

certainty 165:15

272:13

cetera 268:12 298:9

chair 2:5 5:13 24:3

52:14 184:12

chairing 13:6

chairman 23:22 32:10

332:12

chairperson 13:4 15:7

15:10,15 18:11 58:289:12 98:8,18 99:5

102:8 105:18 106:9

106:18 107:4,12

109:5,9 112:16

115:11 116:3 117:11

123:15,22 124:6

126:15 131:7 133:13

134:18 135:2,11

141:19 153:17

154:10 155:22 156:2

156:5 157:2 160:4,21

162:12 165:16166:19 167:1,17

169:21 170:8 171:9

173:10 174:11 175:8

178:15,19 179:9,17

179:19 180:13

181:12 182:12 184:7

225:15 239:20

240:10,18 241:4

242:1 247:13 253:10

256:22 257:10

260:22 261:11

264:12 265:7,14

266:8,18 268:7

269:11,14,16,18

274:20 298:22 299:3

299:6,10,14,17,20

300:2,5,10,19 301:2

301:4,8,13,20 302:7

302:11,14 303:7,10

303:15,19 305:8,12

306:17 308:6,14

309:1 310:3 311:12

312:9 313:20 314:11

316:14 317:14 318:4

318:11,21 319:4,9,13

319:16 321:5,13322:10 324:5,8 327:5

327:10 328:19 329:7

329:21,21 330:8

331:14 332:1 333:1,4

challenge 164:10

challenged 28:6

challenges 22:17 52:4

chance 48:7 110:21

111:4 139:22 152:17

153:7 162:11 259:18

chances 28:13

change 25:17 26:7

27:18 56:13 77:6,7100:13,16 124:1,3

126:12,13,13 134:15

315:21

changed 92:2 93:4

102:22 106:1 177:15

177:16 229:11

234:16 281:11 285:4

288:21

changes 93:10,11 94:9

171:3 228:9 305:4

chapel 149:15

character 280:20characteristics 22:11

207:22 244:17 258:7

259:4,7 264:22

characterization96:15

111:20 112:12

characterize 98:12

characterized 194:11

characterizing 47:13

charcoal 274:9

chart 121:17 123:2

charts 95:12,13 122:19

122:22 123:7

chase 153:8

Chase-Temple 279:8

chatting 330:15

ChB 10:12

check 92:6,7

checked 139:1 261:6

315:20

checks 95:17,18 96:7

121:19 122:9,12

checkups 139:18

chemo 290:11

chemotherapeutic166:8

chemotherapy 22:1424:3 26:6,10,11,13

27:3,4,13,17 35:12

35:19 39:8 42:7,11

42:14 44:8 45:7,9

46:15 47:8,10 53:4,6

53:21 54:8,9 55:9

60:15,16,18,20 61:14

63:4,9,10,16,17 64:4

64:7,19 65:15,18

66:2,12 67:2 68:1

78:9 85:7 87:8 88:5

88:10 96:19,22 97:4

97:11,12,14 98:10,1298:15,16 99:1 105:10

105:14 111:2 112:10

112:12 114:15 115:6

115:7,10 117:8

127:19 128:11,17

138:14 139:11,14

148:5,10 150:14

151:4,12 166:17

167:15 176:20

chemotherapy-specific46:21 48:18

CHERYL 9:9chess 144:10

chest 69:11

Chicago 278:2

chief 3:7 4:11 24:4 27:1

167:22 184:14 186:4

child 277:2 283:22

284:19

childhood 18:20 60:6

children 18:18 24:8

28:22,22 32:15 39:14

53:10 55:17,19,20

56:5,7,14 118:17

131:4 139:21 144:11

144:15 152:7 153:9

163:1,4,5 166:2,4

167:4,9 208:3 282:5

283:1 290:13,19

children’s 4:12,16 5:14

13:16 14:16 24:1

25:18 29:1 35:8 62:4

chills 31:8 43:15 64:15

85:22

chips 279:16

chlopherabine 56:15

56:17

choice 115:17 139:10286:15 290:13

chondroblastic 68:12

107:15

chondrosarcoma68:12,12

choose 136:12 275:22

chose 199:2 204:6

chosen 159:12 204:14

205:18 322:7

Chris 184:14 277:16

328:1

Christopher 11:18

chronic 31:17 214:8267:18 290:12

294:18 295:12 296:4

296:15 298:19

CH.B 8:15

Ciba 19:14 20:3

Ciba-Geigy 19:13

56:22 61:4

circled 103:15

circularity 251:5

circulation 30:20 273:4

274:16

circumstances 113:10279:4 307:10

cisplatin 26:15 42:21

43:1 60:21 61:16

63:11,21 86:14,17

101:14,16,19,20

102:1 109:13 148:8

159:14 161:14

citations 23:11

cited 47:12

claim 92:9 134:9,10

234:10 236:6

claiming 236:2 247:11

clarification 170:1

171:15 304:5 308:15

317:14

clarifications 90:1

171:10,12 240:2

clarify 90:13 98:5

105:1 106:18 108:1

125:1 131:13 174:12





Page 8

clash 157:19

class 29:18

classification227:20

Claude 6:3 181:19

clear 26:2 27:11,22

67:10 110:19 114:11137:16 148:9 158:7

164:1,4 166:10

168:16 170:3 171:5

175:13 178:7 305:6

305:15 320:1 321:18

325:14

cleared 140:21 274:13

274:17

clearly 36:17 67:10

97:3 101:13,14 102:1

105:3 117:12 134:1

157:15 160:15 166:5

178:22 211:20223:18 236:7 272:10

288:14 318:14

321:19 323:13

328:14

cleave 273:2

Clifford 8:7 11:14 14:6

14:6 15:14 16:3

136:16 140:9 145:4

181:10,10 182:12,15

261:5 276:5 291:2

294:8 298:21 300:4

302:21 303:2,5332:19

Climbing 282:20

clinic 4:3 14:11 116:6

139:2 181:15 279:9

315:20

clinical 3:15 4:11,19

6:4 9:8,10 12:6 19:4

19:11,16 21:8 26:8

34:13 36:7 41:15

52:22 53:11 54:5

56:11,13 57:19 59:12

59:14,20 60:4 67:5

70:18 76:5 98:20

99:2 108:2,3 139:6

141:12 145:20

146:14 147:3 149:6

166:13 168:2 170:20

182:5,7 184:16,19

185:5,14,18,22 186:3

187:11,20 188:3,10

188:19,20 189:10,16

189:19 196:9 197:22

204:1 207:17 220:16

222:1 223:12 224:7

225:18,21 226:3

227:11 230:10231:10 267:21

304:20

clinically 21:10 36:6

44:9 55:9 117:3

203:4 222:4,20

239:16 240:22

257:16 266:5 327:7

clinician 28:9

clinicians 189:12 253:6

clock 324:12,18

close 45:10 47:9 212:13

212:21 217:10

closed 20:5 107:18closer 239:6

CML 267:18,18

CMV 196:11,12 200:8

CMV-specific196:1,8

Coagulation 188:5

204:16

coated 197:13

codifies 51:1

COG 9:20 20:12,13

21:22 23:8,9,10 28:4

28:8 34:18 35:8 36:4

37:3,5,7,11 38:6 40:340:6 41:22 44:18

45:18 54:20 55:2

62:18 68:4 70:17

76:4 91:10,16,18

92:5,11,15,17 93:20

94:1,3,4,22 95:1,4

96:1 106:4 119:11

120:7 122:6 129:15

132:4,5

COG’s 91:21 93:8

cohort 33:12,14,21

62:11,14,16,17,19,20

65:10 68:3,7,18

73:15

cohorts 85:5

COLESVILLE 1:11

colitis 197:7 272:7

collaborating 169:1

colleague 153:14

272:18 302:8

colleagues 41:21 56:6

165:20 167:2 178:14

209:3 257:14

collect 92:16,18 120:8

collected 36:22 40:6

42:8 43:11 67:1585:11,13,14 88:19

232:13 235:19

267:19,22

collecting 40:2 268:3

collection 35:7

College 145:14

colon 194:7

colonoscope 272:9

Columbia 181:18

combat 151:18

combats 153:3

combination 26:10

61:14 114:15 115:7,8117:8 167:14

combinations 26:17

51:11 191:4

combined 232:5

311:22

combining 53:4 97:15

193:14 234:9 238:1

come 57:4 119:4

121:20 124:7 135:7

138:21 175:12 197:6

198:14 200:8 209:21

223:16 224:11 247:4261:2 277:17 278:2

281:13 287:16 317:3

323:21 326:16 332:2

comes 45:5 165:5

188:22 260:3 268:13

280:5

comfort 282:5

coming 118:12 128:20

159:5 198:2 211:15

commend 143:14

163:14

comment 18:9 91:16

92:22 94:14 95:2

96:13 99:18 104:6

109:11,22 113:2

116:4,11 118:13

121:13 127:20

130:16 132:1,14,16

157:3,13 162:11

169:13,14,15 171:16

175:10 177:12 184:5

239:3 241:12 243:19

245:21 247:15

257:14 259:20

270:13 271:6,7 315:9

331:15commented 141:19

161:17

comments 87:16

106:20 113:12

123:21 162:9,13,15

162:19 165:18

166:20 179:1 257:11

269:17 305:12

312:11 316:14 318:7

324:6 326:15 330:11

committee 1:5 2:3 3:1

10:6 11:7,12 12:12

13:11,13 15:19 16:816:18,21 17:1 23:4

24:4 90:4,5 123:21

135:18 136:1,10

141:1 144:5 145:7

153:18 154:4 156:7

162:14 164:13

166:21 170:1 171:11

178:21 180:1,19,21

182:20 184:13,17

189:9 240:9 267:11

275:6,11,20 303:8,13

304:7 305:9 307:11317:22 321:6 330:20

332:4

committees 24:2

144:14

common 18:17 25:1

54:4 60:7,8 74:2

85:17 124:8 150:5

219:5,12,19 220:21

221:3,12 287:16

commonly 25:8

communicated 140:21

Communications

294:19

Communion 282:8

community 57:6 142:9

143:5 307:3 325:18

comorbidities 208:16

companies 53:15

company 20:4 132:22

163:14 165:4 175:19





Page 9

175:21 185:14 186:6

186:10,11 317:3

327:18,20 328:3

comparability 108:17

120:2

comparable 79:3 86:1287:4 244:22 263:2

compare 65:14 81:2

97:4 162:5 201:3

compared 34:2 38:8

39:7 66:20 71:2

73:20 76:20 86:8

88:9 202:18 227:10

233:11 239:2 241:3

241:10 249:19

comparing 26:20 35:22

50:5 57:17 80:22

252:20

comparison 35:11 36:344:3 48:3 75:10

77:16 79:21 80:13,17

98:1,3,4 107:9

110:12,12 215:8

230:7 231:18 232:21

237:16 238:16

241:10 273:11,14

311:9 329:2

comparisons 47:22

48:2 78:17,20 79:1

compassionate109:4

compelling 73:2 89:190:11 164:8 166:13

168:10 178:13,13

211:18 241:8 245:7

245:14 252:18

compensate 70:9

competing 32:16 223:1

competitor 17:10

competitors 17:7 136:4

183:6 275:14

competitor’s 16:17,21

complete 34:18 40:11

60:17 73:17,20 74:1

88:1,19 142:21

172:19 194:12 196:7

223:5 297:7

completed 24:5 93:21

146:10 172:1 188:2

199:7 227:14 230:2

234:15

completely 110:17

233:13 237:9 286:7

297:8 322:14

completeness 131:5

172:18

completing 74:3 87:9

87:14 188:6completion 187:12

229:16 234:15

complex 56:11

complexity 143:17

compliance 54:16,19

complicate 64:21 69:4

75:17

complicates 81:17

complication 190:14

complications 56:8

150:1 197:3 201:21

251:18 279:2,13

310:7 314:14,18complies 19:8 178:18

258:5,8 318:10

component 29:22 63:6

components 322:22

compound 252:6

295:21

compounded 252:6,14

280:14 295:18 296:1

306:13

compounding 253:5

comprehensive 19:14

comprised 208:8Computational 2:16

compute 46:1

concentrated 255:19

concept 33:19

conceptually 322:6

concern 51:18 153:22

164:6 206:6 219:22

268:6 269:7 321:13

329:11

concerned 109:16

152:8 174:6 176:14

concerning 59:1 87:16

concerns 199:1 201:22

224:10 226:3 231:10

305:21

conclude 97:17,18

176:11 177:9 225:2

238:5 330:10

concluded 67:4 141:10

202:21

concludes 299:1

concluding 242:9

conclusion 38:16 39:20

40:2,5 41:7 57:19

88:3 105:22 326:17

conclusions 20:1841:16 42:4 84:16,17

102:10 257:5

concomitantly 64:18

concurrent 234:13

conditioning 192:9

193:9,13 208:11,13

215:3,4 216:6,16,19

216:19 217:6 227:8

228:12 230:21

232:17,19 235:16

237:19,21 243:7

244:15 245:20 256:4

262:21,22conditions 233:6,22

235:20 259:16

conduct 20:2 57:17

59:4 69:3 75:16

81:16,21 83:7 187:12

187:19

conducted 21:4 32:13

34:16 37:17 38:18

62:3 80:3 82:1,3,4,5

84:22 95:6 168:14

188:10 226:12 232:3

233:9 237:12confidence 38:12 39:11

40:1 42:4 111:16

126:4 165:13 306:6

confident 176:4

confirm 20:17

confirmation 59:21

62:22

confirmatory 22:1

40:11,13 41:8 170:21

304:21

confirmed 40:4 45:19

55:2 67:18 176:12

confirms 113:20

conflict 10:7 11:13

16:2,4,12 53:17

182:13,14,16 183:2

300:22 301:2,3,5

conflicts 301:6

conformance 46:2

confounding 214:20

confronted 250:6

conjunction 11:21

22:13 165:3 189:6

224:21

connection 136:7

275:17conscious 53:16 281:13

consent 67:20 69:2

309:15,17

consequence 51:8

consequences 45:14

220:16

consider 51:10 57:20

66:5 78:12 80:21

93:6 109:13 133:21

155:2 162:6 222:19

236:4 240:21 260:18

308:3 310:3

considerable 33:353:22 195:17

consideration 141:11

257:8 266:4 310:11

327:21

considerations 12:8

204:7 231:7

considered 28:9 35:2

35:14 40:10 71:19

76:9 78:3,4 79:8 83:2

83:15 111:11 125:15

161:15 207:15 232:2

232:7 234:4 248:10considering 255:4

330:16,17

consisted 63:1,10,18

150:9

consistency 21:15

215:10 217:18

268:22 269:7

consistent 36:16 42:11

42:13 47:11,20 48:7

49:1 95:19,20 221:4

242:20 263:6

consistently 141:9

consists 186:20 192:13

consolidation 148:7

constantly 112:14

282:16 289:19

constituted 30:9

constitutes 220:9

constitution 315:6

constitutional 87:19





Page 10

constructed 70:17

71:18

consultant 2:20 4:2

22:16 23:10 44:22

53:16 185:15 190:7

consultants 8:9 23:3Consulting 9:2

consume 293:18

consumer 2:19 13:21

181:3

contact 73:5 83:22

84:1,2,3,6 92:15,16

93:3 120:13 125:11

125:21 129:9 172:5

173:18 174:18,19,20

174:22 229:18

280:12 331:20

332:19

contacted 71:14contain 77:22

contained 76:21

168:18

containing 70:22 87:15

206:20

context 55:21 128:22

135:19 145:1 161:3

230:9 242:6 275:7

312:13,20 313:16

317:19

continual 280:4

continually 150:22continue 119:10

146:18 238:5

continued 11:1 12:1

41:11 42:2 139:13,17

139:18 192:18

195:15 201:2 205:12

251:13

continues 41:9 248:21

continuing 83:7 120:9

contract 17:2 108:15

contraire 263:12

contrast 27:20 56:19

194:4

contribute 65:4 177:4

contributed 62:11

177:10 214:22

216:12

contribution 140:4

control 24:5 35:13

77:20 78:3 80:7,14

81:1,4 88:6,9 90:21

96:16,18 97:5 104:19

200:15 224:6,7 239:2

239:11 265:4 282:15

285:10,16 286:1,16

controlled 80:18 195:5198:19 201:7 229:6

304:12 326:18

controls 34:2

CONT’D 3:2 6:1 7:2

7:16

conundrum 312:17

conventional 27:3,13

106:6 148:10 166:7

convinced 100:12

151:20 178:3 311:8

312:7

convincing 170:11

304:12convoluted 56:22

cool 285:11

cooperative 19:22 21:5

21:7 22:16 32:22

34:17 35:16 44:17

61:7 62:4 98:14

131:3 163:11,13

copies 37:9,9 93:22

94:2,3

copy 17:14 20:11

183:10

cord 276:18corn 252:3 253:1 293:2

293:3,5 295:18

306:13 311:22

312:11

corporate 19:5

correct 102:22 103:8

105:5 106:22 131:20

132:7,12,13 176:1

243:21 327:10,10

correctly 111:10

correlation 328:12

corresponding 245:15

corticosteriods 189:1

corticosteroid 186:15

197:14 210:21 211:8

219:16 221:19

226:10 235:5 238:8

250:20 251:12,17

273:9

corticosteroids 197:4

197:10 206:3,20,21

207:3 238:10,11

241:12 243:13,14

Cosmetic 59:9

cost 42:5 308:16,18,20

costs 57:2 307:21,22couldn’t 197:16 255:17

265:4 280:10 281:22

332:14

Council 24:1

counter 250:17

countervening 256:1

countries 199:19

couple 94:20 112:17

126:18 155:7 269:17

272:9 316:13

course 11:22 36:4

86:10 87:3 99:11

100:7 150:19 159:1189:7 200:10,11,12

222:3 224:22 230:21

251:10 292:11

293:10

courses 63:2

cousins 288:18

covariate 216:3,5

covariates 216:1 223:1

cover 58:16 197:21

covered 17:12 60:5

183:8 278:10

crackers 293:17cramps 219:4,8,17

crap 317:11

creams 206:20

created 195:8

CRF 121:17 123:2

CRFs 37:8,9 43:9,14

87:16 88:16 91:8

92:12,15 93:5 95:1,4

121:20

crimes 282:11

criteria 52:4 67:16,21

108:6 143:4,10 157:9

199:9 203:13 226:22

248:2 249:12 305:19

criterion 46:7 47:21

251:10

critical 267:19 274:5

criticize 332:10

Crohn’s 197:7,15

cropped 159:17

cross 38:13 39:12

295:10

crossfire 144:13

crossing 325:13

CRs 297:7

crucial 23:19 29:10Cruickshank 243:18

244:6,10,10 246:15

259:20 260:1,5

262:15,18 263:17

314:6,7 323:16 325:3

325:6

crying 285:14

CT 100:3,4 147:18

cultures 199:15

cumulative 210:21

211:9 226:16 250:20

250:22

curative 155:19 225:6cure 28:13 32:14,15,17

32:20 131:3 134:10

cured 40:19 55:5

161:18

cures 161:20

curiosity 325:2

curious 107:14,22

154:13,19 241:9

248:1 258:9

current 18:8 24:14

28:14 59:2 133:18

168:8 184:4 213:12313:1 330:6

currently 24:3 27:12

108:3,21 114:22

168:1 208:14 252:3

309:3 311:15,17

CURT 9:7

curve 66:9 79:12,12

127:6 162:5

curves 32:19 42:2 55:3

66:22 79:10,14,15

115:13 127:12,12

132:21 165:9,9,11

172:4 325:13

cushingoid 219:18,19

298:8

cut 77:10 300:4

cutoff 83:19 84:7,11

233:19 254:22

cutting 131:11

cycle 295:7,7,13





Page 11

cycles 63:10,13,20

297:2,4

cyclosporin 285:15

292:12

cyclosporine 192:14

cytokine 31:5,7cytokines 190:17

cytomegalovirus 221:2

221:3

C-O-N-T-E-N-T-S10:1

C-reactive 64:16

C.F.R 17:12 183:8

C3a/metabolism271:2

D

daily 211:13 228:17

281:12 282:1

Daly 274:5Dame 145:13 149:17

Dana 13:22

Dana-Farber 181:5

Dana-Farmer 2:17

dangerously 285:21

dark 280:19

data 16:17,21 20:6

22:17,22 23:9,12

27:13,14 28:18 35:7

36:22 37:5 40:3,6

43:20 44:1,8,21

50:21 54:20 56:7,1157:15 59:5 67:15

70:22 72:9 73:9

76:10,11 77:10,10

79:11 82:12 83:19

84:7,10,20 85:10,14

88:16,18 91:8,15,18

92:13 94:16,20 95:4

95:7,21,22 96:4,7

97:16 98:1 102:11,13

104:13 106:1,2

108:12 112:3,4

117:15,17 118:2,9

121:14,18,21 122:3,9122:10,11,17 123:2

125:4 127:22 129:12

141:17 142:12,14,17

156:9,18 157:6,22

163:11,13 164:8,12

164:15 165:6,8 168:7

169:16 171:19

177:17,18,19,19

178:3 184:19 185:6

189:16 191:18

202:13 207:20

209:20 211:4 212:13

212:16 213:14214:11,18 215:20

216:2,17 220:9

222:13 223:17,22

226:4 228:21 229:17

230:1,8 235:22

236:21 239:8 242:11

242:15 243:21 245:7

245:14,14 246:2,3

252:18,19 267:19,21

268:4 271:9 273:13

274:14 296:12

303:22 310:11 312:8

319:17 326:8database 37:4,6,10

40:7,8,10,11,11 45:4

95:5,10,14,16 96:8

121:18 123:3 207:1

218:6

databases 92:20

283:17

dataset 20:11 28:4

37:11 38:6 40:13,13

40:15,18 41:8 49:1,2

49:7 71:3,17,17,18

72:2,4 75:15 76:4,6,876:9,12,15,17,20,20

76:22 77:4,12 81:10

81:13 82:14 83:20

88:15,16 91:9,10,10

91:19 92:5 93:8,11

93:15 103:18 106:8

107:16 113:19

117:15 118:12

119:15 120:1,5,11

122:11 123:12,18

125:8,15 126:2,7,9,9

129:15 130:7 131:18

131:22 132:4,5,12

133:1 142:22 163:8,9

173:20 175:4,4 234:9

246:9 256:9 257:7

datasets 48:10 70:13

70:15,16 76:2 91:14

91:21 92:11 104:22

117:15 118:8 122:5

123:11 141:11 143:6

234:12 238:2

datatset 143:17

date 69:18 71:13,14

77:10 92:18 93:3,6

108:20 125:21 130:2138:11 173:19

174:10 180:8 232:14

dated 94:3

dates 28:2 92:2,14

226:17

daughter 282:8 288:1

daughters 281:10

Dave 181:4 324:15

David 2:14 13:22 16:16

185:20 252:10

day 141:5,9,16 147:13

147:16,17 148:13

149:18 163:2 164:9187:5,5 189:2 192:11

192:17,19 193:1,2,3

194:21 195:11 196:7

199:2,20 201:10,19

202:16 203:1 204:9

204:10,14 205:15

209:2,9,12 210:7,15

210:17 211:1,6,8,17

212:1,11,13,18,19,19

212:21 213:10 217:8

217:19 220:5 222:7,8

226:15,18 229:15,18229:21,22 231:15

232:12 237:15

238:19,20 239:9

240:22 245:7 248:4

248:15 249:3,4,17,17

249:17,18 250:21,21

251:1,14 259:13

262:20 263:1 265:9

265:20,20,22 266:5

266:13,14,21,21

280:2 282:7 285:2,5

286:14 287:7 288:9

288:17 290:9 296:8

312:16,16 313:14

320:4 324:13 325:15

325:15 328:13

days 76:13 200:3,11,18

200:20 201:12

202:16 204:10,19

205:3,10,10 206:2,5

215:12 218:16

228:18,19 229:7,16

229:16 235:10,11

248:5 257:15 258:17

258:19 259:2 260:14

260:16 266:11,12268:9,11,11,12,17,21

269:2 270:3 271:17

279:11 281:7,7,9

286:5 287:19 289:7

295:8 296:18 297:2

310:14,16,19 322:4

323:11,14,16 324:14

day-80 323:10

de 17:11 183:7

dead 100:17 125:15

283:19

deadliest 153:3

deafness 86:12,16deal 123:3 295:9

dealing 271:4,5 281:4

291:22

death 21:13 28:12

32:16 39:14 41:11

76:13 95:17,19

195:21 212:6,8

213:11,20,22 229:18

264:22

deaths 57:8 72:2,3 87:5

88:21 125:7,8 133:1

133:11 148:4 150:11192:5 212:6,7 214:1

320:14,21,21 321:2,3

debatable 157:11

decade 150:7 228:10

230:18 234:17

decades 250:9

decadesm 24:12

December 84:1,2,3

149:20 174:19,21

175:1

decent 293:17

decide 117:9 163:1

178:8

decided 138:11

decision 29:9 33:20

53:17 135:16 204:1

245:19 281:13

290:18 308:13

decision-making 275:3

deck 255:9





Page 12

declared 103:20

decline 195:2

declined 43:17

decrease 238:9

decreased 198:8,9

223:18,20 250:4298:2

deep 220:22

deeper 217:10

defects 121:11

defense 163:8 333:2

deferred 45:22 46:5,6

deficiency 221:20

define 268:2

defined 34:22 52:17

59:18 85:12,18 170:4

201:14,14 226:22

267:7

defines 98:17defining 29:8

definitive 51:14 52:6

63:2

defy 127:22

degree 235:6 246:12

306:6 332:12

delay 49:11 204:12

delayed 57:8 93:17

delayed-release 187:1

deliberation 313:18,19

deliberations 312:10

delivery 197:13demographic 38:19

demographics 226:21

227:16

demonstrable 26:11

demonstrate 41:9

108:16 114:20 168:7

223:7 233:17 239:18

248:22 323:11 329:3

demonstrated 22:3

27:18 31:10 53:5

54:18 57:11 81:6

97:10 211:16 224:2

304:2

demonstrates 21:7,10

21:14 25:17 42:6

66:9

demonstrating 59:15

205:1 217:17

demonstration 36:14

51:5 115:3

Dendreon 144:6

denigrate 247:7

Department 2:8,15 4:2

4:7 5:3,8 8:20 52:15

145:18 146:8 333:1

departure 288:16dependent 100:15

depending 46:15

105:10 193:16 239:3

243:6

depends 128:3 134:16

deputy 182:8

Depuy 146:17

derived 59:11

dermatofibrosarcoma142:11

describe 22:7,10,12

23:12 31:15 32:5

59:3 96:17described 36:12 70:18

76:8 79:17 92:7

113:16,16,17 115:3

119:6 132:4 232:11

description 22:21

78:14 318:12

deserve 153:2,5,9

design 32:21 35:5,20

36:2 42:9 49:9 64:20

65:21 66:4 67:7 78:1

78:6,11 101:15 158:4

159:1,8 168:12170:18 203:11

206:10 227:18

230:13 266:19

294:17 304:19 319:6

319:6,14 322:20

designate 70:14 97:5

designated 8:6 14:6

35:13 71:1,17 181:10

designation 187:15,21

190:4 191:17

designations 229:3

designed 26:8 31:19

35:9 44:16 55:22

56:9 65:8 151:18

162:4 171:1 206:8

267:1 305:2 307:6

329:2

designers 78:4

designing 157:16

designs 157:14 234:18

321:6

desire 214:4

desperate 149:13

152:19 162:21

desperately 161:11

289:13despite 24:7 26:7 28:10

50:12 52:4 151:12

destruction 25:11

detail 168:13

detailed 36:18 75:4

81:21

detect 69:16 111:7

112:7 128:19 206:14

218:4

detected 110:17

detectible 25:14 36:7

determination 69:9,10

74:5determine 56:9 57:21

72:11 74:17 76:13

determined 16:9 60:20

68:22 69:1 149:5

182:21

devastating 288:3

develop 150:18 249:1

298:8

developed 249:4

292:20 293:3,5

322:12

developing 294:3development 19:4,12

19:16 23:2 57:2

141:2,13 143:12

187:8 324:3

developmental 56:21

307:22

develops 225:5

deviate 239:21

devising 268:3

DFS 34:4 36:21 38:14

38:16 39:3 45:3,11

46:10 51:11,12,16,17

51:20 52:1,3 82:6,14

106:13 111:7 112:3

132:20 176:12

DFSP 142:11 143:8,19

144:20

diagnosed 24:20 35:1

37:16 54:22 55:18

61:12 136:21 137:9

278:18

diagnoses 26:4 60:11

208:5 227:16

diagnosis 25:13 32:4

68:10,15 100:7,8

131:6 137:19 147:15147:19 150:16 204:9

227:3 252:13 259:19

diagram 73:12

Diane 287:9

diarrhea 194:13

199:11,18 204:19

280:3 281:2 285:3

290:4 292:14 293:12

312:3

diarrheal 199:19

didactic 145:20

didn’t 94:19 108:10

111:22 113:9 114:5126:3,13 173:12

204:12,20 247:17

263:13 272:16

288:17,19 289:9

323:6 324:19 328:7

332:15

die 24:13 27:19 147:22

149:3 286:8,19

died 72:21 73:7 83:20

84:14 125:12,21

213:9,10,20 218:15

281:17 286:10Diego 14:5 181:9

dies 147:22 172:20

192:4 225:7,8

diet 279:16

differ 46:15 332:15

differed 245:2

difference 42:19 45:8

46:20 47:20 48:6

50:7,15 66:18,21

73:2 83:1 91:8

100:22 101:5,9,10

105:2 108:8 110:13

115:18,20 131:21

132:10 133:17,19

155:9 159:15,17

176:15 203:9 217:5

218:5,13 219:8 237:5

239:12 241:8 246:12

251:3 257:21 258:22

259:6,8,9 269:2





Page 13

270:2,20 274:3

315:22 316:6 325:14

differences 43:2 47:14

47:17 48:5 50:3

91:12 102:18 110:9

110:16 115:21118:14 127:1 154:13

155:15,20,20 193:12

221:17,18 227:18

228:3,11 230:12,15

230:19 235:15 238:3

246:1 315:17

different 42:16 66:5

78:12 83:8 90:19

92:19 95:18 98:19

106:5 125:2 132:12

149:12 150:17 159:3

160:11 177:8 193:14

196:10 223:11228:19 229:7 234:19

234:22 235:3,9,12,14

238:21 243:5 251:2,4

265:18 266:22

278:18 288:6 296:2

314:5 326:11,16

331:11

differential 263:7

differently 245:5

differing 35:16

differs 274:4

difficult 21:8 83:5105:7 159:18 160:2,7

164:16 268:17

310:17 315:11

316:10,10

difficulties 230:10

240:17 241:6

difficulty 112:22

312:15

diminished 222:22

277:14

Dinndorf 6:20 11:4

15:1,1 58:5,9 76:8

84:15,19 89:12 101:7

102:5 108:5 124:11

124:19

dipeptide 29:21

dipropionate 185:3,11

186:14,19 295:2

direct 79:20 120:13

136:3 252:20 275:13

328:12

directed 89:14 151:6

247:16

directing 332:19

direction 46:14 66:13

105:10 258:22directly 30:13 287:12

director 3:10,16,19

4:19 6:15,18 7:12,14

15:4,5 140:12 168:2

182:8,9,11 276:10,19

disagree 96:15 115:19

disagrees 234:11

disappears 30:20 50:14

disapproval 180:2

disavowing 110:7

discharged 249:3

disclosed 300:17,21

301:7disclosure 190:2 225:3

278:9 300:18

disconnect 163:21

175:13,17 176:2,4

discontinuation 195:12

202:17 218:15

discontinuations 43:6

discontinue 139:16

discontinued 119:5

192:16

discouraged 325:21

discover 290:16 310:13discovered 203:16

discrepancies 71:4,5

71:20 72:5,7 76:11

discrepancy 71:10

157:5

discuss 49:5 59:1,6,7

69:5 73:8 74:5 75:3

77:13 81:15 82:17

83:16 84:19 123:13

141:2 156:6 162:16

164:4 167:18 180:16

198:18 225:22 226:3

226:5,7 244:6 304:4

308:7,8 331:12

discussed 21:20 28:18

55:6 65:20 78:6 92:2

111:15 143:9 144:4,9

166:7 168:13,22

234:22 236:16

308:10 309:5 323:12

discussing 58:21

discussion 11:9 12:15

15:18 59:4 69:7 75:4

89:22 90:3 126:20,21

132:18 135:5 154:4

156:1 169:14 184:8212:22 225:16

254:16 256:6,7,8

269:13 300:9 303:14

305:9 309:21 316:15

319:8,10,12 331:6,7

331:10

discussions 15:20

17:22 90:12 107:20

108:1 154:8 168:21

183:18 301:21

330:19 331:3,11

disease 11:20 18:19,20

20:15 21:20 22:924:13,19 25:4,13

27:20 28:12 31:22

32:4 33:17 35:4 36:7

44:2 55:8,14 56:12

57:13,20 68:22 69:19

73:4 78:15 79:10

84:13 99:12 102:16

103:1,20,21 108:20

109:8 112:14 125:20

126:12 131:1 148:1

148:10 150:16,18

151:7,10,14 153:4,7165:21 175:13

184:20 185:5,12

188:1 189:5,13,16,21

190:12,12 191:1,3,9

191:11,14,16,18

192:1,1,3,5 193:1,18

194:5,9,10 195:8

196:15 197:7,15

198:7 199:4,5 200:1

200:15 203:14 204:4

209:6 212:10 214:3,4

214:7,8 219:13 222:2

222:21 224:20 225:6

225:8,12 238:14

249:2,5,13 252:14

253:9 254:1 256:2,5

256:17 264:8,21

267:6 270:5,6 278:7

279:3,13 292:14

294:15 312:22

326:13,14

diseases 130:21 165:21

186:8 197:5 209:6

254:19 321:15

disease-free 21:18 26:1

33:2,10 36:8,1039:19 54:21 65:9

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75:6,7,13,18,21 77:6

77:14 81:16,17 82:19

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93:13 94:11 100:8,10

100:13,14 103:3,6,8

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114:3 124:4 126:21

128:22 131:14

134:10 156:10

160:16 161:7 164:5173:1 175:17 176:3,8

177:18

disease-specific268:4

dismiss 164:20

disorder 190:14 267:12

267:15 288:4

disparate 102:10

disparity 87:7,11

display 215:6

displayed 243:21

disposition 49:6 50:9

73:13distal 25:6 272:21

distinction 314:13

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distribution 37:20

disturbance 303:8

division 2:10 3:7,20

4:11 6:19,22 7:14,19

7:22 9:4 15:3 52:12

182:10 188:4 190:3

199:8 204:15

dockets 17:19 183:15

docs 287:15

doctor 115:17 137:20

138:16 139:1 147:10

doctors 138:15 281:1

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87:16 88:16 122:21

123:1 171:5 176:18

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documents 17:18 92:11

94:22 183:14 211:10

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doesn’t 100:16 108:7

116:19 160:14

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dog 261:16

dogs 33:5

doing 133:4,6 157:21

158:4 173:3 192:16

200:18 205:8 249:22

258:14 260:10,12

308:4 310:4,20 311:4

324:2 325:22 326:6

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dominant 194:8 196:15

213:11,22donor 190:16 192:12

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210:13 215:3,5 217:7

217:12,16 235:4

244:18 259:10 264:1

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donors 206:17,19

don’t 90:7 91:2 94:14

98:11 100:18 102:19

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107:7,16 110:3

112:20 113:3 115:12

117:2,7,10 119:7

121:17,18 128:9

129:6 130:11 132:2

132:13 133:3 152:9

156:12 161:22 165:1

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167:14,22 170:1

171:21 173:5 176:22

178:5 194:16 247:7

251:14 252:22 253:4

253:18 256:18

257:15 260:5 279:4,6

284:6 287:10 291:17

292:8 297:6 298:6299:10 302:3,14

303:9,15 306:6

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311:13 312:14,19

318:4 320:16,17

321:21 326:5,7,15

door 286:13

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Dor 11:16 180:17

184:15,16 186:6,12

190:7 244:11 278:11

294:15 328:2

Dorchester 277:17dosage 193:18 277:13

280:1,2

dose 27:6 54:11,12

63:15,15 64:3,3,5,6,7

64:14 74:18 85:9

114:8,8,14,21 134:4

189:1 195:15 196:11

196:12 199:1,2,4,6

201:8 211:1,8,9,13

218:16 224:7 250:22

251:12,15 273:13,14

274:8,11 277:13282:19 296:20

doses 64:8,19 70:7

74:10,17 101:20

195:2 210:21 229:8

241:3 297:12 310:5

dose-compressed27:4

dose-escalation115:2

dosing 34:14 115:1,1

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235:17 297:11,15

dosorubicin 63:11

double-blind 226:12

227:12

doubt 161:19 163:14

168:20

Doug 272:18

downstream 211:21

247:11

doxorubicin 26:15

60:21 61:16 63:18

109:14 148:8

dozen 109:1

Dr 13:12,14,16,18,22

14:2,4,8,12,14,16,19

14:21 15:1,3,5,7,9

16:20 17:1,4,9 18:1519:10 21:14 22:5,7

22:11,15,19 23:1,1,7

23:9,12,17 29:16,16

31:14,14 32:5,9,9

33:6,8 43:20 44:11

44:15 52:7,10,17

53:1,3 57:15,15 58:2

58:5,9,14 59:6 69:5

73:8 74:21 75:2 76:8

84:15,19 89:12 90:4

90:5 91:4,15 92:1,7

92:22 94:13,17 95:2

95:3 96:9,12,14,2197:20,22,22 98:3,6,8

98:11 99:2,6,7,17,17

99:19 100:20 101:7,7

101:9,12 102:5,8,9

102:14,15,21 103:11

103:16 104:4,8 105:1

105:6,16,18,20 106:9

106:11,20 107:2,7,12

107:13 108:5,10

109:7,10,11,19,21

110:1,5,6,7 111:9,10

111:19,22 112:2,16112:17,17 113:1,1,3

114:4,16 115:6,7,8,9

115:19 116:3,9,10,12

117:11,12,18 118:6

119:2,3,17 120:5,17

120:22 121:1,4,13,13

121:15 122:15,18,20

123:1,8,10,18 124:3

124:6,7,11,18,19,21

125:15,18 126:15,16

127:6,7,8,10,17,17,20

127:22 128:2,7,10

129:3,13,16 130:1,4

130:6,13,15,15,19

131:10,11 132:1,7,9

132:13,16,19 133:13

133:14,15 134:2,17

134:20,22 139:4,4,15

139:22 141:16,18,20

145:6,6,17 146:3,11

149:1,5 153:17 154:6

154:10,11 155:2,3,5

156:5,15,15,16,17

157:2,3 160:4,5

161:2,9,10,10,10,13

161:17 162:3,17,18162:18 163:11

165:16,19 166:22,22

167:1,2,13,17,18,21

169:1,9,21,22 170:4

170:7,9 171:14,15,21

173:10,10,12 174:11

174:12 175:2,5,6,7

175:11,21,22 176:6

177:12 178:15,20

179:4,5,6,7,8,10,11

179:12,13,14,15,16

179:17,18,19 180:18

180:22 181:4,6,8,14181:16,19,21 182:1,3

182:5,7,9,11 183:5

184:8,12 185:4,7,9

185:13,17,20 186:1,3

186:11 189:15,18

190:1,1 202:13

225:15,16,20,20

226:5 230:11 231:4,9

231:9,13 232:1,11

234:14,22 235:14

238:4,7 239:5,20

240:11,11,13,18,19241:5,7,17,19 242:1

242:2,2 243:17,17,20

244:11 245:4,21

246:4,5,14,15,17,18

246:19,19 247:13,14

247:16 248:11,11,12

250:3,19 251:22

252:8,8,10 253:10,11

253:12 254:10,10,12

255:4,7,7 256:7,7,22

257:1,1,13 258:3,6,9

260:1 261:15,16

262:15 263:12,20

264:13,14,20 265:13

265:21 266:8,9 267:1

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321:22 322:9,11,18

324:9,10 325:3,16

326:6,19,22 327:8,11

328:1,1,5,13,19,20

330:1,1 331:5,15,16

331:17,19 332:1,4,6

332:7,14,15,17

dramatic 152:10

270:20

dramatically 106:2drastically 288:21

drawn 92:19

dread 247:5

dream 149:17

dreams 153:8

drill 102:13

drilled 216:16 262:5

drink 284:20

driven 66:19 80:12,17

88:4 100:15,16 127:3

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214:11 215:3 244:7252:15,17 269:6

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drives 127:15 210:4

driving 196:20 243:22

263:10

dropped 56:22 129:19

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drops 248:14

drug 1:1,2 6:11,16 7:1

7:12,14,19,22 8:10

16:10 30:7 54:13

56:14,15 58:10 59:9

59:10,16 74:8 111:13

111:14,17 117:10

133:22 135:14 141:2

143:12 149:6,16

151:5 152:1,16 153:3

154:17 164:16

168:16 169:19 178:4

178:8 182:10,22

186:13,20 187:10,15

188:5,8 189:11 190:4

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280:8 282:1 288:11

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311:15 314:17 317:3

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323:6 324:4 327:1

328:22 330:5 331:9

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193:17 201:17

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290:16 292:6,9

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49:17 75:9 77:15

112:8 149:22 171:2

187:15,21 192:5,21

229:12 238:2 279:13

284:21 285:9 287:13

298:6 305:3

DUGAN 278:15,18

Duke 5:9 186:5 254:11

254:13 311:11

dull 147:7

durability 200:21

202:16 205:3 210:6

323:4,11

durable 204:17,22

222:4

duration 33:22 73:9

228:18 229:15

230:16 235:11

269:22

duty 290:15

dying 173:9

dysfunction 255:17

D’Agostino 5:1 14:14

14:14 90:4,5 94:1397:20 98:3 103:11

126:15,16 127:8,10

127:22 128:7 129:3

129:16 130:4,13

156:15,17 179:6,6

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E 2:1,1 11:1 12:1

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173:8 212:19 215:7

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earliest 25:19

early 19:12 27:16

49:16,17 50:21 100:8

166:13 177:14,17,19

177:19 184:21 194:8

209:22 212:15

214:13 257:14,22

258:7,12 259:4

293:15 325:7

earning 17:6

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284:20 289:3 293:11

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eating 201:12,15

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echo 162:18 165:19

Eckhardt 141:17

Eckhardt’s 141:20

economically 328:17

economics 324:2

edema 194:9,11,16219:18

edge 157:7

edginess 280:17

edgy 280:8

edit 92:6

education 146:17

153:8 330:19

educational 140:19

effect 21:11 46:15,18

51:17 66:14 78:5

83:7,11 97:11,12,14

104:16 105:9,14

107:9,10,10 118:4126:8 127:19 158:7

158:13,14 160:10,12

160:13,17 170:20

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215:21 216:8 217:8

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243:15 258:12,17,18

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263:3,5,9,22 264:6

266:11 269:22

271:13,22 272:15273:22 274:4 283:3

298:7 304:21 311:6

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effective 152:8 195:20

197:2 199:5 327:1,3

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effectively 197:5

effectiveness 59:11

170:12 304:13

effects 42:12 54:5

114:21 115:3 121:2,7

121:10 158:5,10,16198:9,11 211:22

214:6 223:20 244:14

246:2 263:8 264:3

277:11 282:15 288:7

290:11 298:6

efficacy 19:2 22:13

35:21 42:4 50:22

56:10 57:15 58:14

59:7,15 73:10 74:20

75:3 76:3 78:2

170:17 199:1 202:15

204:6 209:8 210:5

226:2,4,6,14 230:8

231:5 233:17 234:10

236:2 237:16 239:15

239:18 241:1 252:21

304:1 305:20 306:5,5

306:7 307:13 309:10

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Efficacy/Safety 10:16

32:7

effort 120:7 143:13

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EFS-based 106:5

eight 22:1 41:4 42:3

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Eighteen 313:3

eighteen-year 24:22

eighties 19:12

eighty-one 85:5

eight-week 195:3

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117:18 150:18 165:4

200:10 215:14219:11,20 221:13

233:3 239:5,6 240:4

242:7 243:12 265:8

324:13

elected 88:1

electrolyte 101:1

electrolytes 219:7

221:20

electron 30:11

electronic 95:5,14,15

96:8 118:8,11 122:11

electronically 94:21elevated 33:7 64:16

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elevation 219:21

eleven 109:3

eligibility 228:2 255:1

eligible 68:3 71:19

109:3 149:5 208:15

Ellis 3:22 14:13 181:17

email 331:21

embarrassing 289:5

embrace 314:16

EMEA 236:4 237:1

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emergent 206:9

emerges 22:22

emphasis 35:10 173:1

173:2

emphasize 97:13

116:12 198:11

210:17

emphasized 88:22

emphasizing 73:1

empirically 160:9

employed 34:15

employing 65:21

enabling 35:21encourage 282:5

encourages 135:21

136:9 275:9,19

endoscope 194:14

endoscopic 199:15

endoscopy 199:13

200:6

endpoint 36:11 51:9,12

59:18 67:14 69:8

75:20 82:18,20,22

83:8,12,13 84:9

88:15 89:6,11 102:17

104:1,3 113:4 114:2114:3 115:22 124:5

156:11 177:22,22

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201:9,11,18 202:3,15

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210:5,16,17 211:17

212:12 214:14 217:5

222:20 224:13

226:14 227:13

229:14,19,20 231:14231:16,19 232:2,6,8

232:13,13,20 233:12

233:14,18,20 235:19

236:17,18 237:6,7,15

238:15 239:15

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242:10,18 245:6,7

249:20 265:1,10,16

265:18,22 267:3,10

269:9 321:11 322:1,2

322:5,16 323:8,8,10

323:13 327:7 328:10

330:21

endpoints 33:1 51:6

67:9,11 75:5 83:1,8

113:10 156:12

192:19 206:1,4 207:6

207:15,18 226:3,15

226:17 232:3,10,22

233:9 234:3,21

236:13 237:10,13,14

242:19 250:2 268:9

268:15,16 269:8

320:11,15 325:19

endure 290:11

end-of-phase 85:11enema 272:8,10,11

engine 97:8

England 325:19

enhanced 111:7

enormous 273:8

enroll 323:20 327:9,12

enrolled 35:4 36:5 61:8

65:2 68:3,6,17 71:7

72:21 73:14 85:4

108:21 163:17

230:13 235:13

246:10

ensure 63:21 72:13,1895:18 135:16 275:4

331:21

ENT 185:22 188:5,15

222:6 225:22 231:14

232:4 233:17 234:9

234:16,19 235:4,10

236:13,16 237:4

enter 49:15,18,21 65:3

65:6 74:12

entered 37:2,4 40:7

62:19,21 70:3 73:16

73:19 74:13 84:2185:3,6 95:9,9,11,12

111:6

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enteric-coated 187:1

229:2

entering 50:4 309:12

321:15

Enteron 186:10 187:19

190:6 295:11

entertain 308:21

enthusiasm 33:3,7

entire 19:16 152:11

194:6 322:7

entirely 243:20

entry 64:22 68:22

91:18 92:5 95:14

103:20 226:21

ENT-002 233:10

environment 163:6

EOI 27:8

eosinophilic 197:8

equal 160:10 195:8

221:7 321:19

equally 35:15 166:3

327:2

equity 190:8equivalence 273:12

equivalent 29:5 273:22

273:22 296:7,21

310:5

era 150:8 159:3

eradication 151:7

152:2

erosion 114:6

erroneous 202:12

error 82:10,22 207:11

232:9 233:13 234:5,7

237:8,11,13

escalated 64:8escalation 34:13 64:10

64:12 74:18 114:10

114:10

escalations 114:18,19

escape 280:16

especially 21:9 46:9

190:22 242:22

essence 171:7

essential 151:5

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216:3 243:13 264:8,9

297:4 322:14,17323:1,15

establish 142:1 170:11

304:13

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198:20

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estimate 43:19 46:21

51:17 55:18 126:4

210:9 291:15,17

estimates 47:2,12

48:18 67:7 209:12

estimating 320:15

et 268:12 274:6 295:1

298:9

ethanolamine 29:19

30:2 58:12

ethical 22:4 170:21

304:22 309:9 310:1

310:20 327:21

ethically 59:22





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Eugenie 9:3 10:21

22:19 52:12 139:4

Eugine 145:17

Europe 28:19 178:14

European 24:6 26:19

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evaluate 65:9,18 67:13

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evaluating 78:5

evaluation 1:2 16:10

58:15 63:7 68:14

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evaluations 69:14

evenly 208:5

event 17:22 72:15

85:10 86:10 87:3

119:22 121:22126:14 175:20 176:5

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315:15 327:6

events 43:12,15 45:6

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72:13 76:22 82:2,6,7

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eventually 83:10

149:22

event-driven 213:17

event-free 33:2 60:12

67:7 81:22 104:2

105:3 164:1 165:8

everybody 248:13

291:4 300:11 326:1

everyday 282:22

evidence 31:16 34:13

36:6 39:3,22 45:8

46:12 48:10,16 51:14

52:5 59:11,13,19

80:15,16 94:5 120:18

121:2 125:20 126:11

128:16 131:2 160:1

166:4,6,14,15 167:5

167:8 170:2,9,15,19

171:8 178:12 211:18

220:2 223:12 236:6

242:14 245:9 272:4

274:17 304:1,8,11,16

304:20 305:15,22313:12 318:17

Ewing’s 146:6

exact 151:1 203:14

209:19

exactly 36:20 44:7

129:20 130:1 132:11

135:7 147:12 245:10

253:15 320:16

exam 69:11

examination 66:8

244:16

examine 155:6 244:13

examining 294:16example 71:10 91:16

91:20 95:17 96:2

116:14 134:13 136:5

141:16 142:7 151:9

159:7 172:21 248:3

249:2 253:9 272:8

275:15 298:10

320:19 326:11

329:12

exceed 57:22

exceeded 28:5

excellent 131:6 163:13165:9 170:18 304:18

exception 54:10 86:12

exceptions 16:13 183:3

205:6

excess 42:19 102:2

112:8 221:19 250:12

excessive 86:17

excipients 30:8

excitement 303:16

330:14

exclude 18:3 76:21

183:21

excluded 68:8,20 72:1

72:3 81:12 86:10

87:4 92:22 103:22

107:15 108:7 119:12

199:17,21 200:2

248:8

Excluding 72:20

exclusion 18:4 67:21

108:6 183:22 203:13

259:19

excuse 300:10 311:10

execution 187:12

executive 8:8 140:12

184:15 276:10,19331:20

exhaustion 137:4

exist 103:9 156:18

310:20

existence 45:13 46:8

80:20

exists 188:1 234:1

expand 108:22

expanded 308:19

expect 266:11 269:21

283:2

expectation 41:2 92:8

198:2expectations 51:17

211:15

expected 42:11,13 50:2

59:17 91:12 197:22

198:7,8 211:21

214:18 236:10

expects 84:9

expense 140:20 332:5

expenses 136:7 275:17

experience 22:16 53:9

53:12 56:6 85:18

167:13 197:1 199:3277:5,7,9 287:22

294:20

experienced 89:17

153:6 203:22 277:3

experiences 147:2

experiencing 289:4

experiential 225:3

experiment 96:10

experimental 6:5 67:1

75:10 77:16,22 78:1

78:2 79:19 80:13,17

80:22 81:3,6 88:4

90:18 96:11,11 97:5

101:4 149:2,16

170:14 304:15

experimentals 90:19

expert 22:6

experts 23:6,7 328:9

explain 111:6 259:17

266:15

explained 118:6 139:6

287:6,15

explains 309:15

explanation 86:15

151:22 265:6 322:8

exploratory 83:15232:7 233:10 234:5

236:12,18 265:17

explored 34:12

expose 165:2

exposed 63:22 196:17

exposing 167:9

exposure 198:8,15

201:5,8 206:3 211:20

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223:18 224:2,6,8,12

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fair 258:10

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Fairview 284:16

faith 279:20

fall 153:8 178:9

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false-positive207:11232:9 237:11

familiar 300:15

families 88:1 149:11

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277:4 284:15

famous 280:21

Fanconi 288:3

far 100:12 109:2,16

121:8 152:7,15

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227:15 267:7 277:8287:19 309:7 311:1

317:6 321:6

Farber 14:1

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266:8,9

farther 329:5

far-reaching 257:5

fast 168:22,22

Fast-track 187:21

fatal 191:13 196:15

288:4 330:21

father 281:14

Father’s 282:7

fatigue 86:1 219:3,17

241:14,15,19 316:11

329:12

fatigued 282:16

FAURE 9:15

Faustian 283:8

favor 38:22 160:18

217:20 224:17

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favorable 188:20

favorably 153:15

260:10

favorite 205:21favors 39:3,22

FDA 11:3 12:5 14:20

14:22 15:2,4,6,18

17:21 18:2 20:14

29:8 40:12 45:2

47:16 50:14 52:11

58:4,6,10 61:10

68:19 71:17,19 72:1

72:4 75:15 76:8,9,9

76:15,18,20 77:4,5

77:10 79:11 81:10,13

84:9 88:15 89:15,19

90:2,11 91:21 94:1498:4 99:8 100:21,22

102:12 103:4,10

107:21 108:4 116:2

117:19 122:16 123:8

123:10 129:8,11,17

131:18 132:1,8 135:4

135:18,21 136:9

141:6 142:4,8 143:2

143:7 153:14 157:5

163:3,8 167:19

171:10 179:21 180:4

182:2,4,6 183:17,20184:18 197:11 205:4

210:6 225:16,17,21

226:4 231:6,16 240:2

265:8 275:1,6,9,19

295:4 304:5 317:16

318:1 321:7 322:19

329:8 330:11,13

331:7 332:18

FDA’s 17:18 50:9 93:4

93:14 104:17 130:13

174:14 183:14 190:3

199:8 204:15 238:5

240:20 326:15

feasibility 34:12

feasible 203:17 308:4

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feature 194:8

featuring 114:1

February 123:11,11

282:13

fed 272:19 285:1

federal 8:6 14:7 181:11

feed 282:3

feeding 274:16 279:17

feel 143:9 160:19

224:14 247:6 282:17284:9 302:3

feelings 105:22

fell 268:5

fellow 283:12

fellowship 146:19

felt 97:11

femur 25:6 37:22

ferocity 279:14

Ferrara 299:13,16,17

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fever 31:8 43:14 64:1585:22 219:13

fewer 120:9 262:2

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fibrosis 31:16

Fidler 52:17

field 191:12 254:16

290:1 322:15

fifteen 35:3 62:20

fifth 60:7

fifties 256:15

fifty 57:8

fight 284:22 290:20fighting 153:1 278:3

279:20 283:13

289:13 290:7,8

figure 163:4,17,18

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273:21

figures 172:17

filed 188:8

filing 123:6

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filters 70:1

final 20:7,14 37:13

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173:13,14,18 174:8

257:22 283:4 288:5

294:11 306:1 313:6,7five-year 55:13 60:11

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FK 292:11

flare 296:9

flared 195:15

flares 195:4 198:6

Flatau 6:9 181:21,21

305:14 316:17 319:3

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flattening 32:18

flaw 330:21

flip 280:11

flow 73:12 118:9fluctuation 102:4,6

fluid 272:10,11 273:1

flulike 54:4

fly 143:18

fo 125:16

focus 77:9 120:9 174:9

190:12 191:15

251:18 267:2,2,12

focused 119:20 186:7

focusing 130:9 173:16

174:8 188:12 296:15

folks 247:21 248:7314:5

follow 59:4 121:12

149:17 198:16 260:7

330:4

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121:9 195:11,12

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27:16 30:19 31:10

47:6 48:9 61:13

71:21 87:16 135:13

138:15 158:3 182:15

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followup 34:6 37:5

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171:22 172:2,18173:17 203:1 205:11

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follow-on 200:21 330:4

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food 1:1 6:11 7:1 8:10

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football 147:6

force 282:3forced 281:22

fore 209:1

Forest 39:2,21

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forget 148:12 169:13

forgiveness 110:2

form 18:17 69:18,19

76:12 95:12,13,20

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formation 25:11

formed 30:6,10

former 138:19 163:7

forming 76:9

forms 37:2 69:13 70:21

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formulating 311:20

formulation 186:20197:19 252:21,21

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forth 113:17

forties 256:13

fortunately 148:22

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forty 70:2

Forty-nine 206:12

Forty-three 174:21

forty-year 25:19

forward 57:4 185:15

187:11,19 199:6328:16 331:4

forwarded 37:3

found 46:4 50:11 139:7

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four 17:6,6,9 26:15

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fourth-year 146:8

four-arm 66:6 67:8

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four-drug 35:12 96:19

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Fox 279:8

fractures 292:1

fragile 256:15 292:4

frame 130:12

framework 313:12

frankly 258:13 282:6

FRCP 8:15 10:12

FRCPH 8:15 10:13

Fred 185:9,21 186:1

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function 67:20 196:6

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G

Gail 128:15 141:16

gain 120:14 200:15

game 144:10 290:2

GARY 3:9

gastroenteritis 197:8

gastroenterologists272:6

gastroenterology197:6 198:3

gastrointerology 185:8

gastrointestinal 188:4188:7 189:6 190:18

194:2 196:19 204:16

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gather 107:17,19

gathering 135:16

gear 270:14

Gee 327:5

gender 38:19 216:9

general 110:4 157:3,14

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generating 141:6

gentlemen 13:4 52:11

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George 5:6,11 12:4

14:17 16:20 17:1

131:10,11 132:7,16156:15 157:2,3

171:14,15,21 179:5,5

185:4 190:2 272:1

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getting 144:13 173:16

260:19 266:16 274:7

282:21 286:22 291:6

306:13 324:1 326:3

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187:2 188:11 191:4

215:15 222:2,13

223:9 227:1,20 228:2

267:5 276:22 277:3

282:12 284:21

285:16 287:16 295:2

296:9 297:22

gift 283:9 288:17

give 15:19 78:14 90:9

117:5,6,7 134:14

167:14 169:18 192:8

222:2 257:6 272:8

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given 22:2 44:21 64:6

64:18 86:5 107:17

114:9 141:14 150:1

169:16 187:4 192:11194:21 195:3 200:20

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209:20 245:19

266:10 285:22

gives 30:3 301:9

giving 133:22 209:14

glad 103:15

Gleevec 142:10,17

143:8,19 144:20

global 242:8

glucocorticoid 220:1

glucose 221:20

go 49:4 75:4 90:12 92:594:8 108:4 122:1

128:8,8,10 131:8

137:4,7 138:8 148:14

162:15 163:8,15,21

167:1 171:14 178:16

203:6 220:13 240:1

249:6 254:18 277:5

286:22 287:9 289:1

290:3 297:14 303:16

306:11 311:6,14

318:7 319:5,21

320:14 324:9 328:5goal 32:14 35:20 60:17

325:1

God 288:8 292:12

goes 195:16 292:15

going 99:16 114:11

116:20 118:11,19

123:19 131:9 134:18

135:11 149:3 154:3

156:2 157:17 162:12

163:18 165:13

166:10 175:8,10

178:16,19 180:14

190:11 193:8 197:19

209:20 218:6 239:21

240:15 242:10

243:10 247:5 250:1

253:17,21 261:1,13

263:7 266:20 269:3

270:9 274:21 276:16

284:14 290:4 291:11

292:5 294:5 299:21

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303:10,19 304:4

305:17 306:1 307:15

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318:7 320:1,4 321:16324:2,15 325:6 326:4

328:20 330:12

gold 36:15 55:11

good 13:5 18:15 23:17

32:10 44:15 52:10

58:9 75:2 136:18

140:11 145:7 166:2,3

171:22 184:13

203:10,21 213:13

225:20 246:20 247:8

247:10 259:15 264:4

265:11 284:5

goodbye 281:18 284:16Gooley 186:1 202:13

320:4,8,8

gotten 249:11 314:2

government 138:19

140:16

grab 286:17 311:7,14

grace 288:8

grade 42:8 43:11,13

85:11 86:3,19 137:1

191:8,10,16,17,21,22

192:4 227:20 228:1

grades 191:2grading 191:2,3

gradually 30:22

graduate 145:13

293:22

graduated 146:7

graft 184:19 189:20

191:6,8 192:22 212:9

256:4,16 267:5 292:5

graft-versus 185:11

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grant 52:18 146:16

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Grant-Versus-Host11:20

graph 79:16 127:1

graphic 210:22

graphs 47:6,8,9,10,11

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grasping 281:2

grateful 143:7

graveside 288:11

gray 33:15

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greater 68:9 70:6

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86:21 203:1 218:17

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230:22 239:10 268:6greatest 244:3 295:22

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grew 281:12

grief 332:8

grim 150:20

ground 124:9

group 5:14 14:17 21:8

21:19 22:16 24:2

29:1 33:17 34:4,21

35:8 36:10 37:14,17

42:16,18 44:17 61:7

62:5,5 106:5 114:18

125:2 127:3,15 130:8

131:4 151:1 158:19

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161:1 163:11,13

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218:18,20,22 219:5

219:11 220:20 221:9

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251:20 253:15 254:9

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263:13 264:7,19269:1,4 273:3 274:12

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groups 19:22 21:5 27:9

32:13,22 34:17 35:16

62:4 126:20 200:19

202:20 208:6 219:9

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growth 24:21 146:12

guarantee 95:14328:11

guess 98:18 112:18

127:12 168:19

218:12 247:15,16

248:1 252:5 254:3

265:13,14 266:18

291:15,20 292:10

302:3 305:14 317:8

317:11 321:13

guidance 144:18

guided 34:13

guidelines 235:22237:1

gun 287:1

gut 194:5 197:21,21

200:17 272:18,22

274:15,15,19 284:2

287:13,21 291:12

319:19

GVH 190:5 191:9,19

192:13,16,18,21

193:2,14,21 194:3,19

195:4,21,22 196:20

197:17 198:4 199:10

199:12,18 200:17,22

201:7,9 203:15 204:9

205:12,14,16 206:12

212:20 262:3,9

263:15 309:11 311:3

311:4 312:2 313:5

326:1

GVHD 184:20 188:11

188:21 198:5 201:18

204:2 206:1,14 209:9

209:15 211:16 218:9

222:4,14,19 223:9,17

224:6,8 227:1,20

228:4,4 229:6 232:16237:18 241:1 256:21

276:22 277:3 279:13

281:4 282:11,15

283:9,13,14 284:1,21

285:10,16,22 286:16

287:13 289:17 290:9

290:12,22 294:18

295:2 296:4,16

297:22 298:17,19

306:12 313:3,4,5,8

313:16

HH 5:10

habitus 219:18,20

hair 285:7,9

half 19:18 54:12

197:18 227:5 290:20

291:10 293:19

317:21 323:20

330:20

hallmark 212:14 270:1

270:4

hampered 282:14

hand 113:17 159:20,20handle 102:9

handouts 296:13

hands 165:1 280:9

302:20

happen 153:13 157:17

247:10

happened 118:2,3

129:21 130:2,11

198:16 249:12 266:2

285:19,20 323:14

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happening 260:19

happens 93:3 127:15156:22 175:19 176:4

176:17 194:1 248:15

327:6

harbor 32:3

hard 20:20 111:15

129:3 201:10 203:20

204:17 249:19

258:17 270:6 280:7

287:5 289:18 290:20

291:5 315:1,7

Harrington 2:14 13:22

13:22 16:16 117:11

117:12 120:17122:15,20 123:8

156:16 160:4,5

179:12,12 181:4,4

242:1,2 244:12 245:4

246:4,14,17 253:12

255:7 264:13,14

318:19

Harrington’s 256:8

hasn’t 289:21 307:13

hate 133:14

hates 288:22

haven’t 124:19 164:14

164:19 165:14255:21 270:15,22

havoc 282:12

Haylock 2:18 13:20,20

179:13,13 181:2,2

318:18,18 329:9,10

hazard 38:11,22 39:10

41:10 45:10 46:21

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79:22 80:10 81:11

126:3,5,7 131:17,19

160:12 209:14,22

210:11,11 215:21216:4,7,7 218:1

238:12 260:8 263:3

320:20,22 321:2

head 9:4 22:19 52:12

185:8 225:11 279:5

285:8 329:21

headache 31:8

headaches 86:1

headed 148:15

heads 289:12

healing 287:18

Health 3:10 5:13

145:22

healthy 19:19,20

hear 13:8 123:21 164:3

heard 23:21 28:6,7

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172:9,17 226:9,10

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Hello 291:4

Helman 4:18 13:14,14

107:12,13 146:3

156:5 161:2,9 167:18

167:21 169:21179:16,16

Helman’s 162:19

help 199:7 242:5 284:3

285:6 329:17

helped 140:5 245:13,16

306:10

helpful 307:13

hematologic 208:7

225:7 227:3,15

267:12,14

hematologist/oncolo...

181:1Hematology/Medical

3:20

hematology/oncology2:6,10 3:7 181:20

hematopoietic 184:22

192:11 208:21 247:2

hepatic 67:20

heralded 142:9

Here’s 280:21,21

heterogeneous 227:5

heterogenous 227:15

HFD-21 8:9

Hi 254:12

Hickman 249:8

hierarchical 89:6

high 42:3 59:13 143:18

147:5 224:6 229:12

277:13 282:19 306:6

higher 42:18 86:15

101:3 111:4 153:7

155:13 189:1 196:11

196:12 208:7 211:13

216:3 217:2 218:19

241:14 244:22

296:21

higher-risk 209:5highest 55:3 280:2

highlighted 259:8

highly 41:5 51:22 54:5

59:20 170:18 201:22

222:19 304:19 327:1

high-blood 285:21

high-dose 11:22 60:21

63:11,18 109:14

134:7,8 161:15 189:7

192:6 193:5,22

194:20 224:22 229:6

238:11 239:11

246:21 248:20277:12,20 291:19

310:18,21 325:9

high-grade 35:1 58:20

60:10 61:13 62:10,18

63:1 67:17

high-resolution 100:4

high-volume 199:18

HILTON 1:10

hinges 117:17

hint 199:1

hip 277:18

histology 200:7historic 33:14 34:2

historically 99:10

history 19:3 56:21 61:3

95:20 122:13 151:14

322:12

hit 280:7 289:9,21

hit-or-miss 284:4

HLA 206:18 217:12

264:4

HLA-matched 206:17

245:1

hoc 267:22 268:4

Hockenbery 185:20

252:8,10,10

hold 52:13 53:14,15

163:12 293:22

holding 274:15

home 137:6 138:2,12

149:3 203:6 204:12

289:9 332:2

honestly 328:6

hope 66:1 78:8 140:5

144:11,17 149:13

189:9 255:16 270:10

294:4 327:13 333:2

hoped 65:14,17 255:22hopefully 90:8

hoping 193:19

horrible 288:6

horrific 277:7

horrified 147:10

horror 276:22 277:10

horse 292:7

hospital 4:12 8:17

13:17 22:7 137:9,15

203:5 279:12 281:6

281:19 283:13 286:5

287:8 291:14,16

hospitalization 291:13291:13

hospitals 290:21

host 185:12 190:17

199:5 214:3 249:2

282:21

hostage 290:9

hostilities 192:21

222:18

hours 31:5 149:14

282:2 285:2 292:15

293:18

House 149:11Houston 149:8,10

151:9

Howard 145:22

HPA 219:21 223:12

226:19 229:12

270:16 271:8,13,16

HPA-axis 238:17 239:1

239:15

Huard 146:11

hug 288:9

huge 115:18,20 164:16

321:21

hugged 284:15

Hughes 145:22

human 274:7

humans 196:22

humor 147:9

hundred 19:14 35:3

62:6,7,13,19 85:5

167:7,10 273:19

hunt 242:10,15

husband 287:8

Hussain 2:5 11:11 13:4

13:5 14:8,8 15:7,10

15:15 17:4 18:11

58:2 89:12 98:8,1899:5 102:8 105:18

106:9,18 107:4,12

109:5,9 111:10

112:16 115:11 116:3

117:11 123:15,22

124:6 126:15 131:7

133:13 134:18 135:2

135:11 141:18 145:6

153:17 154:10

155:22 156:2,5 157:2

160:4,21 162:12

165:16 166:19 167:1

167:17 169:21 170:8171:9 173:10 174:11

175:8 178:15,19

179:9,9,17,19 180:13

180:15 181:12,12

182:12 183:5 184:7

225:15 239:20

240:10,18 241:4

242:1,2 247:13

253:10 256:22

257:10 260:22

261:11 264:12 265:7

265:14 266:8,18268:7 269:11,14,16

269:18 274:20

298:22 299:3,6,10,12

299:14,17,20 300:2,5

300:10,19 301:2,4,8

301:13,20 302:7,11

302:14 303:7,10,15

303:19 305:8,12

306:17 308:6,14

309:1 310:3 311:12

312:9 313:20 314:11

316:14 317:14 318:4

318:11,21,21 319:4,9

319:13,16 321:5,13

322:10 324:5,8 327:5

327:10 328:19 329:7

329:21 330:8 331:14

332:1 333:1,4

Hutchinson 185:9,21

186:1 187:9 209:4





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216:12 252:9,11

320:8 323:21

hydration 203:7 249:8

249:10

hypercalcemia 314:22

hypertension 219:17314:20 315:14,14

hypertensive 298:9

hypocalcemia 219:3

316:4

hypophosphatemia219:4 316:4

hyporesponsiveness220:9

hypothalamic-pituit...226:19 238:16

hypothesis 171:5 223:7

305:6

hypoxia 219:13H.A 2:5

I

Ian 8:15 10:12 22:5

ice 279:16 287:3

ICH 236:1 237:1

ICU 285:17

idea 90:16 128:20

129:6 141:17 161:20

161:21 198:3 280:22

290:10

ideal 319:13idealized 195:13

identical 221:21 264:5

identified 42:15 61:19

68:7 69:19 70:20

71:4,20,22 72:2

76:11 77:1 96:5

121:22 239:16

identify 178:22 240:5

300:12 318:13

identifying 100:9 128:4

IDM 8:14 9:6 10:9 13:8

18:21 20:7,11,19

23:10 28:3,17 37:1037:10 40:8,13 44:22

45:16 53:16 57:4

58:17 61:6 68:16

70:13,15 76:3,6,12

76:15,20,21 77:11

82:6,11,14 88:22

91:10 92:10 93:21

94:18 107:17,21

108:10 130:9 132:2

136:20 140:18

143:14,21 144:1

145:9

IDM’s 60:5 83:2093:15

ifosfamide 26:16 61:17

63:5,18 79:19 97:7

115:14,14 116:7,7,15

134:5,7,8 158:14,19

159:14 161:6,19,20

165:3

ifosfamide-enhanced65:16

ifos-added 133:17

ignorance 99:9

Ignore 274:9

ignored 283:22ignoring 157:22

II 31:14 33:6,9 43:4

53:1 84:21 85:19

97:10 121:6,9 142:13

166:13 186:3 187:12

188:14 191:10,16,17

191:21,22 192:4

203:15 227:20 228:1

267:5 287:13 309:19

327:16,16

IIB 53:3

III 19:6,21 20:2,6,1121:1,3 22:3,14 32:5

32:13 34:15,16 37:6

37:8 42:6,7 43:6 44:4

44:15,18 49:9 50:18

51:19 54:8 55:22

56:9 61:19 115:2

169:12 185:18,22

187:20 188:2,15,18

189:19 327:15,15

ileostomies 272:20

ileum 197:13,18

ill 224:18

illness 197:17 277:22

illustrate 47:6 151:8

194:4

illustrated 32:18 39:17

48:8 194:14 196:9

illustrates 39:2,21 42:1

43:21

imagine 277:9 284:19

287:18 329:4

imaging 69:14 99:10

99:13,15,21

imbalance 99:14 101:1

171:2 227:7 232:17

237:20 305:3 323:15imbalances 208:6

259:16

immediate 229:1

immediately 147:14

323:6

immediate-release186:21

immune 190:17 192:11

193:6 196:1 198:10

221:5 223:21 256:10

285:15

immunity 30:1

immuno 315:5immunologic 192:21

192:22 222:18 314:5

immunologist18:21

Immunology 6:6

immunosuppression192:7 214:9 222:18

292:11 296:5 298:2

immunosuppressive186:16 201:17 204:2

205:16,18

immunotherapy 18:16

29:17 144:2,4,8impact 80:4 99:13,21

100:1,2,2 124:12,16

173:3 176:5 177:3

214:15 215:18 223:2

257:21 262:13 267:6

331:11

impacted 82:10 93:12

imperative 163:20

169:5,6 290:14

332:20

implications 231:11

implies 191:17,22

implore 153:13

imploring 169:10

imply 173:13

importance 23:19

207:17 278:5

important 21:12 35:12

41:18 59:20 103:17

109:19 114:17 119:9

119:13 133:3,5,8

135:19 152:13 158:1

160:18 164:9 166:2,3

170:19 173:22 175:2

189:11 202:2 230:1

238:15 242:17245:10,22 246:8

254:15 255:8 256:6

258:20 260:6 267:21

268:4 271:3 275:7

281:16 304:20

305:19 313:17

322:11 323:18

328:15

importantly 43:3

222:22 256:20

impossible 59:22

106:17 141:14

impractical 22:2impressed 325:17

impressive 142:17

improve 24:17 26:13

35:19 54:1,18 57:11

168:8 204:6 223:8

254:7

improved 21:17 54:22

133:19,22 177:10

224:8 329:4

improvement 24:11

27:10,16 39:6,9

44:10 50:17 55:10,15243:22

improvements 24:7

66:19 99:10

improves 18:16 41:7

inability 283:3

inaccuracies 70:20

inaccurate 71:12

inadequate 72:10 73:9

76:1 83:18 89:10

106:16

inappropriate 200:2

inch 287:14

incidence 24:21 86:11

86:16,17 101:3

229:12 241:13 262:8

include 31:7 36:9

37:15 44:1 91:14

136:6 210:16 226:16

236:6 275:16 321:18

included 21:21 23:7





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34:21 35:6 44:3

63:21 64:15 68:9,16

70:11 71:20 76:17

81:13 82:12 84:20

85:22 93:5 103:21

108:8 199:9 206:1,4207:4 211:4 219:1

226:17 313:22 314:1

316:4

includes 19:14 60:15

71:19 76:22 85:1

177:6

including 19:17 45:13

48:6 49:2 68:11 77:5

127:2 147:6 220:21

252:4 279:22

inclusion 34:11 67:16

108:6 199:8 203:12

incomplete 219:22239:8

inconsistent 51:16

inconvenience 167:9

incorporate 167:6

incorporated 10:9

11:16 30:5,13 95:15

96:8 329:16

increase 26:5 53:6 54:6

54:9 70:8 232:9

237:11 238:12,22

251:12 255:12

257:22 279:22increased 106:2 110:21

140:15 150:14 323:3

increases 55:4 82:22

255:2

increasing 71:9 216:4

216:7 257:20

increasingly 100:4

incremental 44:10

164:21

IND 61:4 187:9 295:5,6

295:11 307:19

308:15,18 330:2

independent 35:9

170:13 210:18

304:14

independently 28:3

35:21

indicate 155:12

indicated 43:9 61:11

104:10 133:16

224:20 320:10 329:6

indicating 55:4 114:19

indication 56:5 61:10

189:4 224:19 226:11

326:11,12 328:6

329:5 330:7indications 143:9

199:22

indicators 38:20

individual 66:12 80:22

109:21 123:7 254:20

315:19,22

individuals 54:13

254:17 255:5,20

256:3,13,14,20

individual’s 135:19

275:7

induces 31:3

induction 11:22 101:17101:21 148:5 189:7

200:10,11,12 205:7

222:3 224:22 325:10

indulge 323:17

industry 140:16

ineligible 68:7,10,21

76:21 92:1

inevitably 193:5

infection 137:10,16

196:11,13 199:14

202:19 203:10 212:9

213:11,21 221:11238:12

infections 193:6 194:1

198:12 202:1 206:6

220:18,20,22 221:2,7

221:12 247:21

282:16 310:6 315:3,7

infectious 196:15

199:16 201:21

220:19 221:14

251:18

inference 233:6

inferential 207:20

inferior 67:2 80:4,18

110:22 111:5,18,21

112:8 161:6 162:2

298:13

infiltrates 221:13

infiltration 31:13,16

33:17

inflamed 272:14

inflammation 186:22

187:2

inflammatory 31:13,17

190:13 194:10,17

197:5,9 199:3 200:14

253:8inflate 234:7

influence 233:22

influenced 82:9 232:16

237:19

InfoNet 276:12

information 17:16,21

29:4 59:1,8 76:13,19

81:21 95:19 108:12

114:13 123:20

135:15 136:5 154:22

160:8,20 173:21

183:12,17 236:10

257:1 275:15 276:7276:11,14,14

information-gathering275:3

infosfamide 168:21

infuriating 150:21

infused 192:12

infusion 87:19 248:16

ingredient 30:12 31:1

186:13

ingredients 29:18

inhaler 200:16

inhibition 229:13270:17

inhibitor 192:14,15

193:15 296:6

inhibitors 192:17

initial 60:15 63:5 64:7

70:21 96:21 101:8

270:7 322:13,13

initially 243:18 267:4

295:17

initiate 108:19

initiated 19:21 49:13

121:5

initiation 49:12

injections 30:19

innate 29:22

innocent 284:19

innovative 22:8

input 163:20 278:12

331:5

insert 115:16

inserts 37:5 271:1

inside 47:8 287:18

288:10,22

insignificant 94:11

insomnia 198:13

instance 245:12instances 93:9 242:13

Institute 2:17 4:22 6:8

14:1 19:6 20:1 21:6

145:22 146:4 168:3

181:5,20

Institutes 145:22

institution 33:15 69:11

71:6,6,8 77:3 122:2

134:8,13

institutional 27:9

institutions 62:19 95:7

96:6

instructions 17:19138:15 183:15

Instructor 5:16

instrumental 185:13

instrumentation329:15

insufficiency 219:16

insufficient 88:20

113:22

insure 122:2

INT 58:19 59:3,5 60:22

61:7,21,22 62:2,21

65:8,22 69:9 75:377:18 85:3,5,10 87:5

intake 203:7,16 228:16

229:21 235:7 248:13

249:7,18 279:1

intelligent 153:3

intend 261:7

intended 35:5 236:9

intensification 27:6

intensity 193:10

255:15

intensive 253:22

intent 97:4 104:9

intent-to-treat 45:4

68:18 219:2

interact 168:20

interaction 41:17,20

45:14 46:8,10,12,13

46:17,19 47:3,5,7,14

48:10,16,22 49:3

65:11 66:10 68:5





Page 25

75:9 77:16 79:7,9,17

80:16,21 90:11,14

101:22 102:16,19,19

103:1,2,5,7,8,10,14

104:7,8,11,12,14,21

105:4,7,12,22 106:6106:12,15 107:11

110:19 117:16

127:18 128:3,11,16

128:22 134:3 156:18

158:6,8,15 160:17

164:1,5,22 166:6

168:17 174:2 176:14

176:16 178:12

209:17 210:13 212:4

213:8 214:11 215:4

216:14,18 217:7,9

242:22 244:7 264:15

270:5interactions 65:12 66:1

66:4,7,11 78:8,11

88:6 157:18 160:6

interest 10:7 11:13

16:2,4,9,12 17:11

18:2,7 53:17 89:15

144:12 182:13,14,16

183:2,7,20 184:3

295:12 300:22

interested 128:5

201:21 240:3 295:14

interesting 271:14321:12

interests 16:8 182:20

182:21

interfere 46:13,17

104:14 238:12

intergroup 24:6 26:19

61:19 177:21

interim 45:16 69:4

75:17 81:16,20,22

82:9

intermediate 33:1

intermittent 192:15

internal 2:8 21:14

269:7

internally 95:19

331:12

international 61:2

interpret 83:6 158:9,16

158:17 160:12

164:15 216:22

246:11 274:14

321:17

interpretation 10:18

22:18 44:13 46:14,18

52:4 75:17 81:17

89:3 104:13,15 105:9157:18 159:6,18

160:6

interpreted 45:12

46:19

interval 34:1 38:12

39:11 126:4

intervals 27:3

intervention 270:7

322:7

intestinal 197:18

intestine 194:6,18

intolerance 293:3,4

intracellularly 31:2intravenous 30:17

134:15 274:13

279:17

intravenously 282:1

285:1

intra-arterial 134:14

intriguing 242:21

introduce 19:1 44:11

75:5 240:13

introduced 26:6 63:5

139:3 180:20

introduction 10:611:12,17 13:10,13

100:3 180:21 184:10

185:2

intuited 253:20

intuition 120:19

intuitive 253:15

invasive 196:14

investigated 146:12

investigation 50:9

117:8 146:5

investigational 54:17

97:7,8 108:14,18

investigations 52:19

59:12 169:7

investigator 24:4 27:1

32:12 53:1,11 185:22

investigators 65:12,14

65:17,20 67:4 184:16

328:5

investigator-initiated

187:9

invite 184:7

involve 17:22 183:18

involved 23:2 28:1

56:19 105:17 146:4

147:5 264:11 294:17311:11

involvement 18:4 28:2

183:22 184:4 190:21

190:22 191:5 194:3

196:19 227:22 228:5

involvements 18:8

involves 98:15

involving 11:20 189:6

224:21

IR 186:21 229:1

IRB 67:20 68:13

309:10 326:8

IRB-approved 69:1irrespective 331:10

isn’t 100:16 102:19

194:9 295:18

isolate 270:7

isolation 112:3

issue 16:4 54:16 69:8

75:8,12,16,19,22

77:13 81:15 82:17

83:16 112:11,19,21

116:4 136:12 140:16

143:16 144:1,2,4,22

154:12 156:8 168:11168:15,16 182:16

210:4 225:11 226:7

239:16 248:19 256:1

264:2 271:8 275:22

306:21,22 308:5,6,7

309:9,14 319:6 320:5

324:3 328:3 332:16

issued 142:20

issues 12:10 22:4 44:12

45:2,12 53:17 64:20

69:3 75:5 90:22

108:1 110:15,17

121:15,16 124:9

141:2 143:15 156:13

157:16,22 167:16

168:10,11 203:8

207:10 230:8 231:12

238:6 289:5 294:4

309:9 310:20 327:19

327:22,22 329:13

Italy 96:20

items 37:2

ITT 48:9 49:1,2,5,14

114:18 126:2 134:5

263:6

it’s 25:2 30:4 98:3,6101:15 103:16 110:3

110:5 112:9 113:15

114:10,11 120:15

129:3 132:10 136:3

158:6 164:21 172:19

175:5 179:2 196:22

223:16 224:12

242:13,13 246:20

253:1,15 264:9

265:15 266:14 269:3

271:12 273:4,22

274:17 275:13 284:6

285:4 287:16 289:18291:4 292:2,16

296:10,13 305:15

306:9 308:12 316:20

317:5,10,10 322:11

327:8 332:5

IV 30:19 191:8 327:14

330:4

Iyer 295:1

I/II 19:11

I’ll 98:5 121:15 212:13

I’m 15:22 93:7 98:16

102:9 103:15 107:14110:6,7 111:19 116:9

128:7 129:5,10

130:19 131:21 132:7

134:18,18 135:6,6

139:17 146:21

154:12,19 156:2

162:22 163:20 168:1

169:9 171:14 172:12

172:14,21 173:7

175:8 180:22 181:1,6

181:21 190:11 193:8

209:20 225:20

231:11 239:21

240:15 241:9 248:1

249:22 254:12 258:3

259:11 261:1,17

263:20 264:15

266:20 269:14 276:9

278:16 282:14,16,17

283:16 285:14





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292:22 294:13

300:13 301:15

302:11 304:4 305:14

307:14 309:9,15

311:6 315:1,7 316:19317:2 318:7 320:4

325:21 326:2,6 329:8

I’ve 27:14 28:7 100:12

162:22 168:4 171:21

172:9 225:3 272:13

278:18 291:19 292:1

292:6,7,20 293:3

294:17 303:16

307:11 316:22

317:21

J

J 3:5 4:18 8:15 10:1211:18

Jack 280:19

Jaffe 139:4

James 3:12 8:17 22:6

299:13,16,19 300:16

301:1,11,12,19 302:6

January 70:2 123:11

138:14 288:13

jargon 242:4

Jay 281:17

Jefferson 145:14 146:7

Jenner 20:3,5,7,8 57:257:3 61:5 108:10

jeopardy 138:10

Jerry 279:10

JNCI 27:1

Joanna 8:7 14:6 15:22

18:11 181:10

Joanna’s 89:16 240:4

Joanne 3:14 14:4 181:8

job 311:4

Johanna 11:14

Johnny 146:11 280:21

joint 25:6 53:3

joints 282:20Josh 52:17

Journal 41:15 52:21

67:5 70:18 76:5

274:6 325:20

journals 53:8

joys 283:5

judge 144:22

judged 57:1 171:4

305:5

judgment 57:20 98:22

143:14 215:15,16

July 149:20

jump 103:12June 70:1 81:20 293:15

Justice 7:13 182:9,9

304:9

justification 51:18

K

Kanzer 299:2,5,8,12

299:16,18,22 300:8

300:13,13,21 301:3,6

301:10,15,18,22

302:3,10,13,15,19

303:1,4,9

Kaplan 47:9,10 48:13Kaplan-Meier 38:15

39:17 42:1 47:6,8,9

48:9,12 49:20 50:2,6

50:6,10,15 66:9,16

79:10 132:21 207:6

209:12,19 210:9,15

262:1 325:13

Karen 15:11

Karnofsky 206:2

216:13

Keegan 6:17 15:3,3

123:10,18 124:3127:7

keep 123:2,6 128:20

133:14 214:5 314:12

keeping 313:13

Keith 186:3 254:10,12

kept 99:15 280:13

290:3

key 95:9,11 177:21,22

273:21

kidney 190:21

kids 120:21 286:10

290:20

kill 302:16,16killing 302:15 311:3

kilo 195:11 196:5,6

296:8

kilogram 194:21 211:1

229:11 251:9

kilograms 292:18

kind 93:14 124:17

157:20 172:11 173:3

203:14 225:12 244:6

257:21 270:1 285:11

296:10 303:16

309:12 311:9 312:4

312:13 313:10317:10

kinds 157:16 158:2

326:16

Kingdom 24:1

Kleinerman 9:3 10:21

22:19 23:1 52:7,10

52:12 58:3 101:9

116:10,12 121:1,4

133:16 134:2 139:4

139:15 140:1 145:18

149:1,5 161:11

167:13 169:1,9

175:21Kleinerman’s 31:14

33:6,8

knee 25:6 137:3,14

know 90:14 105:20

117:7 118:1,20 121:8

129:20 130:1,11

151:21 158:21

167:14,22 169:18

171:21 172:12 173:5

176:19,22 177:2

178:5 190:20,21

195:20 196:18 197:1197:3 224:12 251:14

253:16 254:3 256:10

266:1,15 272:13,17

274:17 282:9,18

284:6,10 291:17

295:4 298:6 299:13

299:16,17,18 306:19

306:20 312:19

316:19 320:11,16,17

322:18

knowing 247:4 271:3

knowledge 143:11

known 136:3 149:6,7

207:16 239:10

245:20 272:5 275:13

knows 121:3 286:11

KOH 9:17

Krailo 9:19 23:7,9

45:19 91:15 92:7,22

95:2,3 113:20 117:18

118:6 119:3 121:13

121:15 122:18 123:1

Kurt 145:5,8

Kyrou 291:3

Llabeled 128:2

labeling 34:9 116:1

laboratory 86:20

145:17 146:2 168:5

206:9 219:6 221:16

221:17,18 316:2,12

lack 24:11 32:16 41:20

56:3 90:21 113:12

120:20

lacked 281:21 282:2

ladies 13:4 52:11 152:9

184:13

laid 282:11landmark 21:1 133:4,6

192:19 204:11

222:17

language 149:13

lap 283:4

large 21:3 27:8 30:9

46:20 50:3,7 98:13

118:4,16 201:7 220:4

241:2 256:9 287:15

294:18 308:1

largely 92:3 209:22

214:2larger 144:9 190:20

327:11

largest 29:2 34:19

56:20 276:13

large-scale 131:3

155:12

Lastly 17:8

lasts 274:11

late 26:6 28:2 56:8

120:19 121:7,9

123:11 214:1,6

laughter 110:4 163:10

170:6 255:3 260:4278:17 308:11 318:3

326:21 332:3 333:3

Laura 7:4 11:6 14:21

59:6 126:19

layers 30:5,13,22

LDH 38:20

lead 185:4,21 186:2





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206:6 219:7

leader 7:18 8:2 14:20

18:22 29:8 182:4,8

leaders 28:19

leadership 29:10

leads 79:22 100:7102:3 177:9

learned 147:21 150:4

252:19

learning 163:20

leave 277:6 303:3

leaves 277:14

lecture 164:7

led 33:20 99:11

Lee 3:5 4:18 13:12,14

146:3

Leeds 8:18 22:7

left 31:12 39:1 151:9

178:20 234:5 259:17284:16 286:4 296:13

leg 137:14,16,20 138:1

138:1,8,9,11 147:22

148:6 149:22 290:5

length 71:11,15 72:5,7

72:9,12,18 77:6,7

lesions 154:18,21

lesser 74:4 87:13

letter 93:5

letting 163:15

let’s 163:15 171:16

249:2leukemia 265:1 267:15

level 46:1,9 60:1 103:2

103:3,5,11 164:22

165:14 207:8 210:12

212:3 242:7 287:13

levels 48:1 207:14,14

271:19 274:12

Levine 272:19

Lewis 8:15 10:12 22:6

22:7 23:12,17 29:16

43:20 57:16 96:21

99:17,19 134:17

161:10 177:12

178:15

liar 302:10,11

licensed 190:5

licensing 56:10

licensure 190:10

life 28:17 87:21 138:10

150:7 152:11 278:4

282:9,12 283:8

287:20 290:7

lifetime 281:8

life-long 283:6

life-saving 53:19

life-threatening 18:19186:7 277:22

ligand 168:22

light 45:12 142:21

244:13

likelihood 47:4 128:15

309:6

Likewise 136:9 275:19

limit 227:2

limitations 28:10 143:6

limited 152:6 286:7

limits 27:11

line 39:1 66:20,20

163:16 260:9 265:16274:9 280:21 312:16

329:5

lines 249:9 260:9

linger 282:17

Link 3:3 180:19,22,22

253:10,11 255:7

261:15,16 263:12

318:15,16,16 324:9

324:10 325:16

linked 210:18

Link’s 256:7

lipid 30:2,3,7lipids 292:19 293:4

lipophilic 30:4

liposomal-formulated30:16

liposome 31:1

liposomes 30:5,10,13

30:16

list 91:20 93:12 122:1

132:3 173:18 190:20

listed 108:6 218:8,12

236:14

listen 318:5

liter 199:20

literally 83:1 248:20

249:12

literature 192:20 209:5

227:21 309:10,17,18

little 26:7 31:12 50:14

172:12,14 173:7

190:11 193:8 194:2

225:2 242:4 263:21

266:14 270:14

273:20 287:4 291:5,5

306:19 315:11 316:9

live 40:21 117:1 130:17

136:19 139:20lived 149:10 276:21

liver 31:21 190:19

191:4 199:17 227:22

228:4 298:7

lives 152:4 281:11

290:14,21

living 138:4,7 276:17

280:15

local 25:20 271:22

localized 25:13 44:2,4

location 38:21

lock 207:1

lodging 136:6 145:10275:16

log 123:2,6

logical 151:22

log-rank 78:22 125:22

207:7 209:16 231:20

long 19:3 25:5 49:11

55:3 105:13 138:8

197:10 249:12

274:11 281:8 292:12

longer 33:22 41:15

50:13 108:13 152:20

204:5,13 269:21283:2 321:12

longevity 154:1

longshot 149:3

long-term 26:1 57:11

57:14 120:21 121:1,2

213:19 218:4 290:10

295:1,12,15 314:18

look 79:1 109:20 110:9

115:12 116:6 127:1,5

133:18 153:14 158:2

158:5,11 162:20

164:3 165:9 171:18

172:4,19 174:13,16

214:15 223:21

242:16 250:10,12

251:6 262:14 264:3

266:6,21 268:5,21

269:9 274:11 286:21

287:5,9 305:17

310:12,14 313:10,11

314:4,19 315:11

319:17,18,22 323:4

324:22,22 325:1,8

332:9

looked 105:11 121:22

174:6 175:12 177:4206:8 210:21 216:17

219:5 245:14 252:18

282:7 288:18 290:2

315:18,21,21 323:10

looking 105:14 112:3

119:19 128:10 164:7

172:17 191:20 196:1

196:10 211:9 215:2

260:18 261:22 267:4

267:5,6,9 268:15,16

271:1 319:20

looks 158:6 159:12

194:14 242:12253:13 272:12

288:14,22 305:19

lose 325:12

losing 260:15

loss 42:17 86:13 121:10

121:11 194:12

260:19 280:4 281:2

286:4 323:15

lost 84:6,10,12 92:21

129:9 130:14 132:15

133:3 149:22 279:19

288:5 292:17 332:5lot 105:19 133:3

134:13 156:13

163:19,21 165:10

172:13 173:2 178:5

199:20 213:14

245:14 252:1,4

268:10 270:10,12

272:14 291:20

292:17 307:9 325:19

326:2 328:3 332:8

lots 108:16 117:14

love 153:8

loved 289:10

low 46:10 128:19

274:11 297:12

315:10

lower 48:13 49:19 50:6

50:10,15 127:12

187:2 223:8 307:1,1

312:15





Page 28

lowered 202:22

lowering 316:18 317:2

lower-risk 209:5

lower-tract 297:21

low-grade 67:21

Lu 7:4 11:6 14:21,2158:14 59:6 69:5 73:8

74:21 75:2 102:15

106:9,11 107:7

124:18 173:11

174:11,12 175:5,7

luck 266:1

Luckily 138:20

lucky 286:22

lumen 272:18

luminal 273:1

lumps 211:6

lunch 330:15

luncheon 180:7lung 31:20 99:11 139:8

139:12 149:20 151:3

151:16 155:14

221:12 289:16

lungs 30:21 148:1,3,7,9

148:16 151:10 177:2

287:12 289:17

Lu’s 126:19 127:6

132:9

Lydia 3:5

LYMAN 3:9

lymphoma 68:11278:21

lymphomas 254:19

Lymphoma/Myeloma4:7

M

machine 287:1

macrophage 30:8,22

31:3,7

macrophages 30:17,21

31:9,20 33:18

Madam 184:12

magical 304:7magnesium 281:21

magnitude 66:13

Maha 2:5 11:11 13:5

14:8 17:4 180:15

181:12 183:5

MAI 221:9

main 75:5,7,12,16,19

75:21 77:13 81:15

82:17 83:16 158:5,7

158:9,13,14,16 173:1

maintain 198:5 203:6,7

248:19 249:10

maintained 205:2297:12

maintains 211:16

223:17

maintenance 35:19

49:7,13,15,19,22

50:4,8 60:18 63:3,6,8

63:15,20 64:3,5,6

65:1,4 70:3 73:17,20

74:1,3,13,13 85:6

86:4,20 87:10,15

101:19,21 111:3,6

200:16 229:7

major 35:10 43:2171:5 235:15 238:3

247:21 305:21

majority 26:3 43:16

72:13 73:6 173:14

191:10

majorly 28:13

makeup 314:5

make-it-up-ourselves312:4

making 135:16 148:14

malignancies 121:10

278:19malignancy 208:7

212:9 225:7 265:5

malignant 67:17

managed 35:7

management 23:9

91:15 332:18

manager 96:4 123:2

manic 280:19

manifestations 227:1

251:16

manner 27:4 162:2

manual 312:2

manufacture 57:4

manufactured 53:15

manufacturer 17:2

manufacturers 59:10

108:15 307:12

manufacturing 20:19

108:15 307:21

manuscript 21:22

41:14,21

MAP 133:18

maps 85:11

Marathon 283:5

March 76:7 107:19

marched 208:22marginal 45:5 46:18

96:3 104:15

marginally 219:4,18

Maria 4:4 14:2 181:6

Mark 7:7 9:11,19

14:19 23:7 45:19

113:20 287:8

marked 27:20 102:1

297:10

markedly 25:15 26:13

market 57:1 100:13

311:15

marketed 186:16197:15 330:6

markets 178:8

marks 172:4,15 173:8

286:18

married 139:21

marrow 208:20 216:9

231:2 245:1 248:16

259:10 270:2 276:7

276:11,17 278:21

279:1 288:1 293:21

295:3 325:18

marrow-ablative314:15

marshaled 272:3

MARYLAND1:12,13

mass 25:11 148:21

286:4

Massachusetts 277:17

massive 143:13 248:18

matched 206:19 208:5

208:20 212:5 217:13

217:15 279:8 284:17

matches 264:4

matching 244:18

material 247:18

Math 7:8

Mathematics 5:3

matriculated 145:14

Matt 285:12 287:1,13

287:22 289:8

matter 116:19 156:12

159:18 160:14,15

265:19 299:14 302:5

matters 16:18,22 17:3

117:3

Matthew 140:10,12

284:11 288:13

Matt’s 287:9maximum 54:12 64:13

128:15 266:10,11

Mayo 4:3 14:11 181:15

McCarthy 294:9,11,13

294:13

McDonald 12:4 149:11

185:4,7,9,13 186:11

189:15 190:1,2

225:15 239:5 240:11

240:11,19 243:17,20

246:18,19 247:16

248:11,12 257:2

264:20 271:7,20272:3 280:6 309:5,8

310:10 311:19

322:19 326:6,22

327:8,11 328:1,5

MD 4:6 9:4 22:20 33:6

52:13 116:15 139:2,3

145:19 149:2,14

181:7

MDP 29:20,21 30:2

MDS 254:19

mean 37:21 71:8 94:14

102:5 127:14,22129:16,17,20 132:7

152:9 156:20 157:17

158:21 163:2 164:8

171:7 173:13 243:21

250:8 285:3 305:14

314:16 326:10 327:7

meaning 307:3

meaningful 21:10 44:9

54:6 55:9 76:1 83:18

89:10 106:17 203:4

207:16 221:16 222:4

222:14,20 224:9

240:22 259:6 316:8

327:7

means 123:22 130:1

156:10 158:9,15

159:20,20 203:5

241:1 297:7 316:19

meant 282:15 297:5

measure 166:3





Page 29

measured 188:21

241:15,20 298:1

mechanism 52:17

92:13 93:2 96:4

308:18 330:3

mechanisms 91:14307:17

medial 15:1

median 38:15 39:18

40:15 41:4 72:16

210:22 212:19

250:22 296:19,22

medians 316:5

medical 3:13,16 4:2,5

5:9 6:21 7:21 11:3

14:9,10,13 23:22

37:1 57:21 58:7

145:14,17,21,22

181:6,8,12,14,16185:18 186:4,5

187:22 189:19 224:5

240:14 250:6 254:13

284:17

medication 280:5

medications 285:22

medicine 2:7,8 3:8,15

4:6 5:13 138:13,16

147:10 185:7 197:17

198:6 199:3 204:20

205:12 286:1 325:20

meds 286:13meet 52:3 59:17 143:10

240:12,20,21 284:11

meeting 16:6,12 17:20

23:19 135:18 136:8

142:6 144:7 180:16

182:18 183:2,16

275:6,18 330:21

332:21 333:6

meetings 204:15

meets 46:7

Meier 47:10,11 48:14

member 99:19 141:5,9

141:10 185:21

members 2:4 3:2 4:9

6:1 13:11 15:20

52:10 90:4 135:4

144:18 145:7 154:4

162:14 170:1 171:11

174:13 178:21

180:19 184:12 304:6

321:6 332:4,10

Memorial 8:21 22:12

32:11

memories 283:11,13

menopause 286:21

mental 121:11 290:11mention 226:2 230:7

mentioned 94:19

110:14 124:11

144:17 231:13 239:6

247:19 250:3 278:2

294:5 296:10

merging 326:16

merited 188:19

mesenchymal 68:11

mess 287:11

message 218:12

met 75:21 82:19,20

141:2 156:11 286:10metabolism273:5

metabolite 220:14

271:11 273:8 274:2

metabolized 272:17

metabolizes 30:22

metastases 26:4 32:2

60:11 69:17 146:13

147:19 148:3 150:12

151:2,19 152:2

154:16 155:13,14,16

177:2

metastasis 25:14,15metastasized31:20

metastatic 21:19 35:4

36:7 44:2,5 55:8

62:17 68:2,15,22

85:2 103:21 108:20

146:5 148:1 150:18

151:7

meta-analysis 215:9

236:1,2,5,8 237:2

meter 64:8,11,12

114:21

method 69:16,20 75:14

77:14 113:16 178:2

207:6 234:11

methodology 126:1

methods 36:20 78:15

81:10 236:21

methotrexate 26:16

60:21 61:17 63:11,19

109:14 161:15

192:15

methylpred 296:20

methylprednisolone189:8 296:7

metrol 298:10

Meyers 8:19 10:1721:14 22:11 23:1

31:15 32:5,9,10 53:1

53:3 57:15 96:12,14

97:22 98:6,8,11 99:2

101:7,12 105:16,18

105:20 109:21 110:1

110:5,7 111:19 112:2

119:17 130:15,19

133:13 155:3,5

161:10 162:3 175:22

176:6

Michael 3:3,18 14:12

180:22 181:16318:16

Michael’s 264:16

Michigan 2:11 14:9

181:13 300:14,15,22

microcospy 30:11

micrometastatic151:9

microphone 89:18

107:2 300:3,6 318:14

microphones 178:21

microscopic 26:3 31:22

32:3

mid 197:20middle 50:2

mid-1980s 26:7

mifamurtide 58:11

139:7,11,13 140:4

149:7,19

mike 300:4

mild 54:14 86:2 191:18

milestone 289:7

military 138:18

milligram64:11

186:22 187:1 195:10

211:1 229:10

milligrams 64:7,10,12

64:13 114:11,12,12

114:21 134:6 187:4,5

199:2 251:9 273:17

274:1,7 280:2 296:8

296:20

milligrams-per-kilog...250:22

milliliters 199:20

Mills 8:13 10:10,15

18:15,21 19:10 29:16

32:9 91:4 92:1 94:17

96:9 99:17 103:16

108:10 109:7,19113:1 114:16 115:7,9

115:19 116:3,9 119:2

120:5,22 121:13

124:21 127:17

129:13 130:1,6,15

132:1 155:2 173:10

173:12 175:2,6

mind 105:19 164:14

170:1 252:5 331:11

minds 240:1

mine 302:8

mini 193:9

minimal 56:8 171:4277:13 305:5

minimis 17:11 183:7

minimizes 329:1

minimizing 200:1

minimum 72:13,20

142:2 144:22 311:1

Minnesota 181:15

284:16 288:16

minority 208:21

minus 48:4 97:18,19,21

minute 91:16 119:18

323:17 330:14minutes 31:5 131:8

135:8 261:2 292:16

300:12

miracle 149:15 150:1

miraculously 149:1

mirror 289:1

miserable 286:8

mismatched 217:12

missed 281:16 282:7

331:6

misses 197:18

Missouri 3:21 5:17

14:13 181:18,18

mistake 324:11

mitigation 51:18

mobile 41:5

modality 69:15 151:5

model 32:20 46:11

48:17 216:1

models 196:21





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moderate 54:14 86:3

moderating 185:17

240:15

moderator 189:18

modern 220:8

modest 140:18modification 37:11

40:14 93:14 132:6

modifications 77:4

91:21 94:10 118:10

132:3

modified 70:8 71:17

93:10

modify 76:15 109:1

mofetil 193:15,17

moiety 30:2,3

moment 152:12 293:4

323:6

Mommy 285:6 286:8money 328:4

monies 187:11

monitor 185:18 189:19

240:14

monitoring 16:17,21

monster 280:9

month 67:18 68:10

137:6 149:20 291:9

291:10

months 25:21 94:20

137:18 139:14

213:14 281:21282:17 283:4 289:2

291:14,14,16,18

302:7

mood 286:20

moody 280:8

Moores 3:17

morbidity 24:15 53:20

53:22 184:21 212:15

morning 6:13 7:3 8:12

10:4 13:5 18:15

23:17 32:10 44:15

52:10 58:9 75:2 90:3

135:3 136:18 140:11

145:7 163:21 304:10

morning’s 13:6

mortality 53:20,22

184:21 189:2,2

191:22 192:4 213:6

214:22 215:19,21

217:19 218:2 222:15

222:16 223:2,2,5

226:18 246:2 251:21

313:14,15 320:4,6,13

Mortimer 3:14 14:4,4

99:6,7 100:20 179:10

179:10 181:8,8 241:5241:7 314:11,12

318:20,20 328:19,20

Mosbacher 52:14

mother 137:9 147:9

149:8,10,14 277:2

286:19 290:6

mothers 288:10

Mother’s 147:16 288:9

motivation 50:20

mouth 280:11 285:13

move 175:9 187:19

254:17 286:5 328:16

329:5moved 172:16 187:11

moves 242:18 245:7

movie 280:20

moving 185:15 329:21

MPP 52:6

MPT 20:10 28:1 39:5

MTP 18:15,22 19:4,17

20:8,21 22:13 23:2

28:1,2,6,11,18,21

29:2,5,11,17 30:14

30:19 31:11,15,19

32:12 33:4,8,11,1934:13 35:19,21 36:1

36:4 38:3,4,8,9,22

39:3,22 40:17 41:7

41:10,16 42:7,16,18

42:21 43:5,12,15,18

43:19 44:7,8 45:5

46:14,20 47:4 48:13

48:15 49:10,13 50:11

50:12 52:18 53:4,5

53:10,12,15 54:3,7

54:11,17 55:1,4,8,19

56:2,19,21 57:4,17

57:18,22 58:12,19

59:2,8 60:2,4 61:4,11

61:18 63:7,14,15

64:2,3,5,17,22,22

65:5,7,15,17,18,19

66:8,12,12,14,21,22

67:1 70:1,4 73:6,18

73:19,21 74:8,12,14

74:16 77:20 78:5,18

78:18,19,19 79:2,2,3

79:4,5,6,12,13,15,15

79:19,20,21,22 80:1

80:2,5,7,8 81:3,3,4,4

81:7 85:7,7,8,9,18,2086:4,9,9 87:2,2,6,8

87:15 88:1,5,10

90:19,20 101:6 102:1

104:15 105:9 107:9

109:14,17 111:2,14

111:22 114:8 115:15

116:8,17 117:7,21

120:20 125:6,6

127:13,19 128:8

129:4 130:8 145:12

147:3 149:6 151:4

152:4,8,19 153:15

155:10 158:13159:11 160:10 165:3

168:7 174:1 177:9

MTP-containing 35:22

70:3 88:11

MTP-PE 29:19 66:1

78:8 168:20 175:15

MTP-treated 66:18

86:16

MTP’s 57:7

mucosa 197:21 199:12

272:10,14 273:1

274:15mucosal 194:8,11,16

mucosis 287:6

mucositis 247:2

muddies 156:19

Mullen 277:16

multi 27:8

multiagent 22:14 42:7

42:14 61:14 115:10

multicenter 21:3 62:3

170:17 188:15

191:19 203:17

226:11 234:19

304:18

multilayered 30:10

multiple 48:2 176:19

216:12 232:2,4,6

237:12 268:10,16

269:8

multiplicity 207:21

multisystem190:14

MUNSELL 9:11

muramyl 29:18,21

58:11

muscle 147:8 219:4,8

219:17 286:4,4

musculoskeletal146:20

music 148:20

mustache 285:8,10

mycophenolate 193:15

193:17

myeloablative192:10

193:9,13 208:15,18

216:6,20 217:4 243:2

243:11 244:15,16

245:16 248:21 254:9

255:13 262:6,21

263:4,11,13 264:19

269:1 312:19 314:15myeloablatives 244:21

Myers 5:15 13:18,18

133:14 161:13

179:14,14

M.B 8:15 10:12

M.D 2:5 3:3,9,14,18

4:1,4,10,14,18 5:10

6:3,14,17,20 7:11,14

7:17,20 8:19 9:3,7,9

9:13 10:17,21 11:4

11:11 12:4,7,11 14:2

M.Sc 8:7 11:14

N

N 2:1 11:1,1 12:1,1

name 13:5 30:15 78:21

136:18 140:11 145:8

184:14 187:6 240:14

278:1 300:13

named 186:10

names 180:20

Nancy 7:20 12:7,11

182:5 225:20

national 4:22 6:8 19:5

20:1 21:5 35:16145:21 146:4 168:2

181:19

natural 99:11 151:14

242:16

naturally 198:16

nature 47:7 118:7

192:10





Page 31

nausea 86:1 87:20

194:13 199:11

219:14 277:8,9 284:9

293:13 312:3

nauseated 249:9

NCI 13:15 34:18 52:18NDA 11:3 20:21 21:21

40:9 61:10 76:2

103:19 142:19

180:16

nearest 296:19

nearly 143:15 148:4

227:5 228:10 230:18

279:17,20

NEBY 9:13

necessarily 56:10 91:2

92:20 95:5 249:6

263:10 310:8 318:4

necessary 66:5 78:1280:21 204:13 239:18

necrosis 110:22 111:5

112:8

need 10:11 18:3 22:7

23:13,15 24:9,15

49:4 52:1 57:21

113:11 132:14 145:1

161:11 165:12

166:16 169:18

170:13 183:21

187:22 204:3 224:5

262:2 299:21 303:17304:14 307:4,14

needed 117:9 143:17

189:1 204:2,17

215:17

needing 165:20

needle 137:15

needs 78:3 162:21

201:13,15 203:19

negating 260:20

negative 149:21 199:16

200:8

negative-nitrogen

248:18

negotiates 330:9

negotiation 116:1

negotiations 326:20

neighborhood 251:9

neoadjuvant 60:16

63:2,10,17 98:10,22

150:13

Nerf 287:1

Network 276:7,11

never 45:20 92:9 110:8

143:11 148:12

152:17 218:22

272:11 273:3 281:17283:10 286:11

289:20 307:4 321:16

322:15 328:15

new 8:22 22:8 24:9,16

25:11 29:9,18 56:3

56:14 58:10 59:16

60:9 127:2 148:16

165:20 188:8 270:19

295:5,6 304:6 325:19

newly 35:1 54:22 61:12

news 147:20 279:6

Nguyen 136:17,18,19

nice 262:12 286:17Nicholson’s 280:19

night 145:10 290:2

nightmare 280:15

nightmares 288:6

nights 162:19

nine 76:22 168:1

284:14 286:2 291:7

296:14

nineties 19:12

ninety 70:5,6

Ninety-eight 70:2

Ninety-five 40:21ninety-three 62:7

nitrogen-balance248:19

nocardia 221:8

nodules 31:11,15 33:16

33:18

noise 259:18 260:2

nomenclature 186:18

nominal 82:15 157:10

non 159:13 193:8

216:5 244:15,20

255:12 262:5 263:10

312:18 314:14

Nonclinical 9:16 31:21

nonhematologic 86:19

nonmetastatic 55:14

57:13 58:19 62:10

65:9 68:6,17 71:1

73:14 85:2 166:17

168:9 169:20

nonmetastic 35:1

nonresectable 62:18

85:3

nonresponders 250:8

296:14,19,22 297:3

nonspecific 273:2nonspecified 232:3

nontoxic 327:3

non-clinical 19:11,13

non-Hodgkin’s 278:20

non-laboratory 86:6

non-marrow 315:4

non-matched 264:1

non-MTP 117:22

non-myeloablative193:22 208:11,13

216:15,20 227:10

228:12 230:20

237:21 243:2,7 244:1245:13 246:7 253:15

253:18 254:6,7

255:14 257:3 261:19

262:9,22 263:4 314:3

314:13

non-myeloablatives246:10

non-myeoablative232:19

non-prespecified237:10

non-randomness172:11

non-resectable 68:2

non-responders297:14

NON-VOTING 6:12

7:2

normal 196:3,6 199:18

218:9 220:11 238:19

271:16 290:8

normally 137:8 303:15

norms 21:4

North 34:17

notable 274:10

notably 220:21 223:10

notation 71:13

note 35:12 44:6 73:16

81:8 86:13 96:3

114:17 119:9,13

190:8 192:3 202:11

209:21 219:3,19

noted 18:4 71:10

183:22 229:9 244:8

283:20

Notes 43:14

Notice 47:7 192:19

213:13 273:6,15noticed 242:22

notion 260:2 314:16

Notre 145:13 149:17

Notwithstanding 88:13

Novartis 142:19

novel 18:15 29:17

November 107:18

139:14 141:1,7 281:7

no-MTP 125:2,6,9

130:8

number 26:7 55:4 71:4

73:16 74:10,17 82:2

87:7 91:11 92:1997:9 113:21 118:17

125:3 132:9 172:6

173:8 176:19 186:17

191:14 212:20 218:7

220:4,19 239:4,7

243:4 252:12 261:22

265:9 268:18 271:14

297:1 314:1 320:12

320:13,14

numbers 43:2 61:21

119:19 130:6 154:14

154:21 239:2 244:22251:19 257:6 314:4

315:16

numerical 98:3,4

numerically 218:19

nurse 13:20 181:2

nurses 280:11 287:2

nutrition 203:7 285:1

nutritional 249:18

nutritionist 201:11

249:18

nutritionists 203:18

OO 11:1 12:1

oatmeal 293:17

objective 42:17 142:16

143:4 144:21 166:4,6

167:4,8 241:16,19

objectively 152:10

objectives 234:21





Page 32

obligate 254:22

obliterans 221:14

observation 32:3 80:3

observations 129:18

213:15

observe 79:18 106:12observed 42:22 48:5

64:9 101:13 102:2

obtained 17:14 20:11

52:18 83:10 183:10

199:12 229:18 230:1

obviated 110:18

obviates 112:5

obvious 86:15 106:12

106:14 211:10

obviously 102:10 159:4

188:22 210:18

247:20 259:18

occur 57:8 133:12173:14 254:20

occurred 72:17 87:3

221:14

occurring 133:1

218:17

occurs 56:3

October 61:9 138:12

142:7 279:12 293:19

ODAC 8:6,8 11:9,9

12:14,14 14:7 141:4

141:5,8,10,19 143:18

144:17 156:1,1180:16 181:11

303:14,14 330:18

odds 217:20 266:4

offer 151:8 284:2

office 6:16 7:6,8,12 8:5

15:5,11 17:16 92:5

95:8 182:11 183:12

officer 6:21 7:21 15:2

184:15

offices 91:18 95:1

official 8:6 14:7 141:8

181:11

Oh 15:22 269:16

oil 252:3 253:1 293:2,3

293:5 295:18 306:13

311:22 312:11

oil-mixed 311:16

okay 15:10,15 91:4

100:20 103:3 107:6

116:12 119:2 121:4

131:7 134:2,3 135:2

154:10 170:5 266:5

268:17 274:20 300:1

300:15,16,16 301:15

302:12 303:7 304:9

305:8 314:10 329:7333:4

old 129:12 136:21,21

277:17 284:14 286:2

311:7,14

older 208:18 244:21

254:17,20 255:18

256:3

oldest 281:17

old-fashioned 194:3

OLIVER 9:15

once 38:1 118:17

154:12 155:19 189:9

195:4 207:16 245:5285:20 287:22

322:18

ONCOLOGIC 1:5 2:3

3:1

oncologist 8:16 147:14

181:7,9,13,15 205:20

254:13 312:7

oncologists 28:20 56:1

56:2 134:9 165:2

203:22 252:17

oncologist/hematolo...

181:17oncologist’s 148:12

oncology 2:20 3:20 4:2

5:14 6:16,19,22 7:12

7:14,19,22 13:20

14:9,11,13,17,18

22:6 29:1 32:13,21

34:10 36:15 41:15

50:18 52:22 55:11

57:5 62:5 67:5 70:18

76:5 121:12 144:5

146:3,20 167:22

181:2 182:10 186:4

188:8 209:3 250:6

ones 119:2 126:13

242:16 251:17

297:16 315:13

316:13

one-third 37:15 39:13

one-year 234:2 253:14

263:10,14 265:1

269:3,5 313:15

one’s 201:15

ongoing 61:2 98:14

120:11 308:3

onions 30:12

onset 232:16 237:18open 11:8 12:13 108:21

123:6 132:18 135:10

135:12,17,22 147:15

261:7 275:5,9 309:21

322:14 326:19

opened 287:11

OPENING 276:4

opens 117:14

open-label 62:2 69:9

operating 147:14

operation 139:12

operations 95:4

opinion 28:9,19 101:12124:1 176:15

opinions 156:16

opportunity 101:22

123:13 145:8 152:12

152:14 153:10

184:18 276:8 278:1

283:22 294:3

opposed 126:9 134:14

156:22 157:20

216:10 266:21

opposite 105:9 254:3

269:3optimal 49:10 54:11

option 24:16 278:22

291:6 327:4

options 144:15 326:9

oral 136:1 185:10

186:19 187:7,8

188:11 189:4 196:18

197:4 198:21 202:21

203:7 222:3 224:5

225:10 226:9 227:13

228:15 229:20

272:19 274:7 275:11

295:1

OrBec 3:4 11:19

180:17 184:19 185:2

187:6 189:4,10,20

224:19 226:9 238:8

257:19,22 258:12,17

271:1 273:13,16

284:5 304:2

order 10:5 11:10 13:3

40:1 44:19 72:11

91:6 95:15 147:9

180:12

ordinarily 158:5

organ 196:20 255:17organisms 221:11

organization 140:13

276:10

organs 190:18,20

orientation 192:9

original 46:2 61:4

202:13,14 206:10

211:15 223:7,15

235:8 295:11

originally 206:8 236:9

originated 71:5

orphan 18:20 21:9

56:12 187:10,15189:12 190:3,4 199:8

orthopedic 146:9,10,17

146:22 147:13

Orthopedics 146:14,18

osteogenic 61:18

osteomyelitis 150:1

osteopenia 292:1

osteosarcoma 18:17,17

19:18 20:10 21:1,9

23:20 24:6,10,16,19

25:1,4,19 26:12,18

26:19 27:12,19 29:329:6 31:12,22 33:8,9

34:19 35:2,16 37:16

37:19,22 38:1 39:16

41:13 43:22 53:5

55:1,15,18 56:12,16

56:20 57:9 58:20

59:2 60:2,6,10,14,20

61:2,13 62:10,18

63:1 67:17 68:13

73:4 96:21 97:9

98:13 99:9 107:15

116:14 136:22

137:19 138:6 143:10

143:12 144:8,12

145:2,12 146:5,13,18

146:22 147:2,16,22

148:2,6 149:2 150:2

150:4,5,9,22 151:13

152:22 161:12

165:22 166:18 168:3





Page 33

168:4,9 169:20

175:20 176:18,21

177:1,21

ototoxicity 42:22 43:3

43:4 54:10 101:3,13

102:2ought 263:21

outcome 24:7 25:16

33:12 35:19 48:22

49:2 51:12,15,19,21

56:13 80:5 88:18

93:12 119:7 162:6,7

196:19 206:7 223:22

242:9

outcomes 3:11 115:18

115:20 198:17

202:19 211:9 214:20

223:8 224:3 243:5

298:14outlined 233:16 328:9

outlines 58:16

outpatient 249:4

outside 17:20 47:10

177:2 183:16

outstanding 124:9

overall 20:16 21:18

26:14 47:16 54:21

67:14 71:8 72:7 73:2

75:6,19,22 77:7

82:18 83:3,6,14,17

83:17,19 84:8 89:1,389:5,7,9 93:13 103:5

103:11 106:11,13,15

106:16 108:8 110:18

112:4,21 113:4,5,8

116:18,20 122:12

124:8,17 126:4 129:7

132:15,20,22 154:12

160:12 164:12,15

165:6 171:19 176:13

178:3,6,10,11 207:11

213:12 217:5,16

218:3 230:4 233:1

234:3 236:12 263:6

307:13 321:11

overcome 112:21

overlap 42:21

overlaps 79:15

overperformed 97:18

oversight 35:7

overview 185:2

overwhelming 150:11

overwhelmingly 318:1

Ownership 187:18

owning 17:10 183:5

o’clock 180:6

P

P 2:1,1 3:12 38:11

39:10 45:4,5,9 46:4,5

46:11 47:19 48:21

79:7 80:10,12 81:11

81:13 82:15 83:9

94:10,12 104:11

126:2,7 131:17,20

132:9 157:10 202:9

207:12 209:21 210:4

231:20 233:11

package 19:13 115:16

172:14 266:6 271:1packed 149:8

page 10:2 11:2 12:2

131:15 141:19

174:14

paid 23:10 53:16

136:20 279:4 294:20

332:5

pain 25:9 87:19 137:3

137:4,7,8,13,13

147:7 290:17

painful 283:2 293:6

paint 286:6pairs 50:16

pairwise 47:17,20,22

48:3,5 98:1

palatable 253:2

Pam 13:20

Pamela 2:18 181:2

PAM-intestinal 197:17

pancreatitis 292:20

293:6

panel 31:18 52:11

panels 316:21

paper 95:6,7 110:3,5

118:13 123:6 141:3158:12 159:19

296:13

papers 227:20

paperwork 138:20

paradigm 113:6

paradoxic 296:11

paraphrase 163:7

parcel 308:13

pardon 287:22

parent 87:12 283:22

286:12 290:7

parents 43:8,17 144:12

148:18 153:9,10Park 293:20 294:14

Parklawn 17:16

183:12

part 16:5 17:12 33:4

35:8 44:20 93:12

96:9 122:18 129:17

146:10 166:9,16

182:17 183:8 196:9

244:1 267:21 308:12

308:20

participant 18:2

183:20

participants 16:9,1618:3,6 182:21 183:21

184:2

participate 37:7 92:17

139:9 316:19

participated 52:20

62:6 147:2 294:14

participating 34:20

participation 190:9

particular 24:10

131:13 154:14 162:8

247:17 295:12

particularly 32:1172:19 193:17

201:21 221:2 258:13

259:6 274:10

parts 100:3

party 265:15 284:14

part-time 282:14

pass 95:16 121:19

143:13 177:20 298:7

passed 122:12

passing 281:16 283:16

patent 190:5

pathology 68:11,21

151:13

pathophysiologic258:11

pathophysiologically270:12

pathophysiology190:16

patient 5:16 6:10 13:18

36:14 37:1 51:14

52:6 65:5 68:14,15

68:21 71:13,15 73:5

74:3 75:22 87:12,17

95:21 98:19 117:1,22

122:5,12,18,21 123:5123:7 133:22 134:21

140:19 142:15

151:17,19 152:5

163:17 169:19

173:19 181:21

187:16 196:17

201:16 204:18

207:22 218:22

224:16 227:18 238:9

248:3 249:22 277:4

295:5,7,10 297:3

304:2 306:2,14 314:8

317:4 323:19 328:7patients 13:9 19:17,18

20:10 21:13,19 25:8

25:12,15,21 26:3

27:2,12 28:20,21

29:12 31:10,11 32:3

33:9,12,16,21 34:4

34:22,22 35:3 36:5,9

37:6,14,15,18 38:2,3

38:8,9 39:5 40:17,19

40:22 41:2,9 42:13

43:8,16,17 44:2,3,6

45:8 46:22,22 48:1348:14 49:6,14,16,21

50:1,3,8,10 53:5

54:14,22 55:5,7,14

56:1,20 57:7,10,12

58:19 60:11 61:9

62:7,11,13,17,19,20

62:21 63:12,14,19,21

64:1,2,16,21 65:2,4

65:10 66:19 67:16

68:2,6,9,10,13,17,19

68:21 69:1 70:2,9,9

70:10 71:1,7,9,19

72:1,3,11,14,18,20,21

73:3,5,7,13,14,16,22

74:2,7,11,12,13,15

76:21 77:7,8,18

81:12 83:20,21 84:5

84:10,12,14,21 85:4

85:6 86:7,8,14,16,21

87:1,7,14,17,22





Page 34

88:18,21 92:1,16,21

100:9 101:15,18,19

103:19,21 106:6

108:19,20 109:1,8

111:1,5 114:17,19,20

116:6 118:2 119:5,10119:11,12,21 120:1,6

120:10,14 121:6,8

124:12 125:1,5,7,9

125:19 126:11 129:9

130:2,11,17 140:17

141:3 142:14,16,18

143:8 144:9 145:2

150:6,15,17,22 151:1

152:4,7,8 153:1,2,6

154:1,14 155:9,10,17

161:18,20,21,22

162:21 168:3,9 172:2

172:5 173:17 174:17174:18,22 175:20

176:17 184:17

187:17 188:11,14,16

191:6,8,15,19,21

192:16 195:13,15,22

196:2,4,16 198:12

199:11,17,18,21

200:9,18 201:6 203:2

203:5 204:1,11,12

205:8 206:12 207:3

208:1,7,9,9,15,17,18

208:22 209:1 211:19212:9,12,17,20 213:9

215:13,13 216:11

217:2 218:7,9,10,18

218:21 220:19,22

221:15 222:2,13

223:9,19 224:13,18

225:4 227:5,9,11,19

228:3,8,9,12 229:5,9

230:20,22 232:18

233:4,20 235:8,18

237:20 238:19 239:1

239:4,7 241:2,22

244:2,2,14 247:1,3

247:20 248:2,6,20,22

249:1,3 251:3,7,20

252:12,19,22 254:18

255:2,10,12,17

256:16 257:2,4 259:4

259:9 261:19 262:4,6

262:9,20 263:22

264:3,4,11 266:1

267:16 271:13,15,15

272:7,20 276:20

277:12 278:6 295:13

296:5,16,22 297:6,10

297:16 298:1,3,7,9298:17 302:16,16,17

305:18 306:3,8 307:7

309:13,15 310:1,19

312:8 314:1 315:19

317:9,12 320:21

323:5,19,21 325:9,11

325:19 326:5 327:9

327:12 330:6

patient-driven 276:10

patient-loss 71:12

patient’s 151:15

Patricia 6:17,20 11:4

15:1,3Paul 8:19 10:17 22:11

32:10 163:14

Pause 294:12 300:7

301:17 302:18 303:6

pawn 144:9

pay 195:19

payment 136:6 275:16

pays 308:16

Pazdur 6:14 7:11 15:5

15:5 169:22 170:4,7

170:9 182:11,11

307:16 308:9,12,17319:5,7,11,15 326:19

330:1 331:5,17,19

332:1,6,14,17

pB 291:7

PE 30:3

peak 24:21

PEARLMAN284:9

pediatic 33:8

pediatric 4:13 8:16

14:18 19:22 21:5

32:13,21,22 34:10,17

55:22 56:1,1 57:5

62:4,5 121:12 130:17

142:15 146:3 165:2

167:22 181:1,20

pediatricians 161:1

162:10,13

pediatrics 3:6 4:15

5:11,16 8:21 9:4

22:19 32:11 52:13,14

165:21 326:4

peer-review 53:8

pegging 156:21

penalty 192:2 195:19

pending 246:17

Pennsylvania 136:19139:20

people 18:16 20:22

23:19 24:8,13,16,20

25:3 27:19 29:6,6,11

40:20 118:17 134:7

152:18 163:19 173:6

195:1 200:2 211:10

211:12 214:5 220:4,6

221:6 242:8 243:11

245:12,15 249:9,14

250:4 253:20 276:15

277:14 283:18

302:20 307:18 308:3310:13 311:3,16,17

321:19 324:19

329:12 332:9

peptide 30:1,4

perceived 57:1

percent 24:12 25:5,14

25:21 26:2,10 27:7

27:19 28:12 34:5,6

38:8,9,12 39:7,7,11

40:19,21 41:1,2,12

42:12 49:15 55:13

57:12 60:10,13 65:270:5,6,21 72:17,21

73:19,20,21 74:9,11

74:15,16 83:19,22

84:1,3,5,10 85:22

86:7,14,21 116:21

120:1,5,7,10,16

124:10 126:4 129:8

129:10,14,20,21

130:14 131:4 148:2

150:10,15 152:8

165:8 167:7,10

174:17,19,20,21

191:5,22 196:3,3,6

201:15 202:5,5,17,18

203:2 206:13,14

207:7 208:8,9,12,12

208:19 209:13,13,14

210:9,10,11 212:2,2

213:6 216:11,21,22

217:6,13,14 218:1,18

219:11 220:6,6,10,10

222:6,8,9,11,15

223:4 227:9,10 228:4

228:8,8,12 239:5,6

248:14 259:10,11

273:19 289:15 298:3310:13,15 313:15,15

percentage 150:14

201:13 212:17 323:2

perform 76:1 79:6

83:18 89:10 106:17

162:2 332:7

performance 80:5

90:16 169:11 206:3

244:19

performed 34:19 45:20

69:5 75:10 77:17

80:1,14 81:20 82:7

82:13 125:22 132:19133:9 233:15 234:8

236:11

performs 79:20

period 25:19,20 70:4

70:10 100:5 187:6

195:3 200:6,21 204:5

204:7 205:6,9,11,11

210:19,20 212:14

222:11,12 235:10

251:13 281:11,12

325:10 328:11

periods 173:8 249:20peripheral 208:22

216:10 219:18 228:7

231:1

Perry 3:18 14:12,12

109:10,11 110:6

111:9,22 179:7,7

181:16,16 306:18,19

319:1,1 331:15,16

332:4,7,15

Perry’s 316:18

perseverating 314:12

persistent 194:13

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person 28:16 167:12

248:9

personal 147:1 152:11

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PET 99:13,15,21Peter 4:10 13:16 17:9

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pharma 8:14 10:9

11:16 13:8 136:20

145:10 180:17

184:15 186:6,12

190:7 244:11 278:11

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Pharmaceuticals186:10 187:19 190:6

pharmacies 296:2

Pharmacology 4:11

274:6pharmacy 252:15

pharmacy-compoun...297:19

phase 19:6,11,16,21

20:2,6,11 21:1,3 22:3

22:14 31:14 32:5,12

33:6,8 34:15,16 37:6

37:8 42:6,7 43:4,6

44:4,15,18 49:8

50:18 51:19 52:20

53:1,3 54:8 55:22

56:9 61:19 65:4,674:1 84:21 85:19

86:4 97:9 115:2

121:4,5,9 142:13

166:12,13 169:12

185:18,22 186:3

187:12,20 188:2,14

188:15,18 189:19

203:15 267:18,18

309:18,19 330:4

phenomenal 330:22

phenomenon 260:17

Philadelphia 4:12

13:17 145:15 279:9

283:5

Philip 294:9,13

phone 4:17 15:8

phonetic 139:4

phosphate 219:7

phosphatidyl 30:2

58:12

photograph 284:12

285:12 287:6 288:14

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physical 69:11 198:14

283:3 289:18 290:10

physician 74:4 87:13116:6,10 137:15

138:5,6 140:3 149:18

151:21 201:16

215:16 249:22

physicians 116:15

134:14 278:7

physician-dependent117:6

physiologic 259:15

physiologically270:11

Ph.D 2:14 5:1,6 6:9 7:4

7:7 8:1,3,13 9:1,15

9:19 10:10,15,1911:6,18 12:9 16:16

picked 57:2 120:20

picking 98:4

picture 274:5 286:6

287:5 317:20

piece 287:14,16

pills 280:10 281:22

293:2

pink 51:12

pioneered 56:2 185:10

Pittsburgh 146:9

pivotal 34:16 188:2,15202:8 203:11,12

208:1 215:8 217:20

218:7,11 222:15

240:15 309:20

310:15

PKHRIKIAN-KYR...291:4

place 29:9 139:6

171:18 180:8 272:9

286:11 332:22

placebo 198:18 200:11

200:20 202:5,17

208:2,10,12 209:10

209:20 210:3,8,10

211:2,6 212:2,7

213:5,9,20 215:13,13

216:22 217:1,14

218:13,20,22 219:12

219:14 220:6,20,21

221:4,9,15 223:11

225:13 227:11

231:22 236:20 237:5

237:17 241:3,11

251:1 257:4,8 259:1

260:10,13 294:16

310:12,15 326:17placebo-controlled

187:13 188:13 222:9

226:12 227:12

309:12,22 310:4

326:7

plan 36:12 45:19 46:7

58:16 89:7 123:16,19

148:16 153:10

206:22 229:15

planned 41:19 45:18

46:6 65:12 83:3

206:10 233:5 235:20

planning 46:2 309:1plans 108:22

plateau 269:20 270:11

platform 203:10

platinum 134:14,15

play 189:11

pleasant 292:16

pleasantly 214:17

please 49:4 89:20

99:18 106:18 115:12

116:11 131:8 153:14

155:4 170:8 178:17

178:20 179:17180:13 190:8 240:6

243:19 261:8 263:18

290:18 299:20 300:4

300:6,20 303:12

311:13 318:9,13,15

329:20 331:21

332:19

pleased 22:5

pleasure 23:18

plot 39:2,21 148:20

209:19 210:15

213:16

plus 36:1 64:11,13

90:19,20 102:3 111:8

114:12,12 159:10

200:10,11 222:3

327:8

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pneumonia 221:14

podium 84:15

POG 61:21 62:5,11

68:1 78:5

point 89:20 110:20

131:13 134:4 137:7

148:22 149:4 151:8

157:8,21 208:13213:22 220:10,14

227:4 240:7 245:22

246:8,20 247:17

248:4 253:19 257:1

258:20 260:3,6,7

262:3 263:7 266:7

268:11 278:9 280:9

286:3 293:9 306:2,14

307:12 308:14 310:5

316:18 317:8,15

319:20 323:18

328:22 331:3

pointed 162:3 204:17234:14 235:14 251:3

330:1

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pointing 103:17

points 236:4 249:17

316:15 320:3 331:6

331:12

policy 140:15

political 138:20 144:10

144:13

pool 85:1 105:4,8,13

107:6 119:12pooled 65:13 75:8,14

77:14 78:4,15,21

80:5,9,12,16,19

81:10,10 82:13 88:3

88:7,13,22 97:12,14

110:12 117:22

127:10 156:9 158:2

160:19 171:18

217:19

pooling 65:18 117:16

127:11 226:3 230:7,8

234:11 235:22

236:21 237:1

Pooling/meta-analyses238:1

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population 21:17

25:18 37:18 41:5

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85:2 226:20 227:18230:14 235:13

portion 299:1

pose 102:14 245:5

261:13

posed 167:19 179:20

180:3

position 190:8 306:20

positive 22:21 51:7,13

51:15,20 113:10

160:11 236:7 242:12

312:17 317:10

possibilities 118:22

possibility 120:19143:20 171:2 270:15

305:3 309:4 330:3

possible 45:13 47:13

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66:3 78:10 89:21

139:3 147:20 240:8

264:15 290:17

possibly 219:15 288:4

post 213:3 215:19

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267:22 268:4 289:6

postoperative 148:7postpone 306:1

postsurgical 63:7

postulated 258:16

post-hoc 83:5 144:2

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233:10,15,16 234:4,8

236:11,17 305:4

post-occurrence176:21

post-one-year 243:5

245:17

post-randomization189:3 213:3 217:22

223:3 230:4 233:1,2

233:8 234:3 243:14

245:8,9

post-recurrence155:18 177:5

post-study 233:21

post-transplant 206:5

208:8 213:3 222:16

223:5 226:18 229:19

232:12 237:15 288:5

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post-treatment 34:7post-treatments

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potent 186:14 202:1

273:4,9 274:4

potential 16:11 20:9

33:7 57:8 146:5

168:16,22 172:2,10

183:1 193:5 234:1

238:9 246:6 265:5

320:17 327:4

potentially 141:11

167:8 225:6 294:18

pounds 279:18 286:3289:4

powder 295:22

power 153:13 206:13

218:4 260:18,19

279:21 320:5,11,12

320:13,15 323:15

powered 36:11 65:8

66:8 67:12 109:20

110:8,9 112:2,18,20

115:22

powerful 151:12

PowerPoint 19:9 23:1629:15 32:8 44:14

52:9 58:8 75:1 84:18

91:22 101:11 120:4

125:17 127:9 130:5

156:4 171:20 184:11

189:22 225:18 231:8

244:9 250:18 258:2

259:22 262:17

263:19 272:2 294:10

325:5

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309:16 310:1 327:21

practicality 324:1

practically 320:7

practice 27:13 56:4

134:16 228:9 248:17

312:2

practices 36:16

practitioner 134:16

prayed 149:15 152:14

prayer 150:9

prayers 284:3

preamble 170:4

prechemotherapeutic150:8

precious 283:9precision 113:12

preclinical 19:3 52:16

preclude 16:5 136:14

182:17 276:2

precluded 151:17

preconceptions 28:7

177:14

predict 124:12

predictable 148:2

predicts 196:19,21

prednisolone 12:3

225:1

prednisone 12:3 189:7192:6 193:5,22

194:20 195:2,14,16

195:17,20,20 196:2,5

196:6,11,12,17 197:2

198:8,9,11,13,15

200:1,10,11,13,15,19

201:4,5,8 205:7,9,19

205:22 211:1,20,22

215:17 217:3 221:6

222:3 223:8,18,20

224:1,7,8,11,13,14,22

229:6,10 241:3246:22 247:3,4,5,8

247:10 250:4 266:3

273:7,11,14,17,18,22

274:1 277:11 280:1,6

280:13 286:16

291:21 292:7 298:10

310:14,16,18,19,21

311:1 325:10

prednisone-induction210:2

predominantly 205:21

preexisting 259:7,16

preface 157:4

prefer 297:20

preference 118:1

preferred 178:2

premalignant 67:22

premature 213:19

premise 223:15

preparation 21:22 45:1

172:13

preparations 228:22

preparative 253:22

256:4

prepare 148:18

prepared 19:13 152:11165:2 202:13

preparing 20:6 41:22

preponderance 39:2

39:22

Prerequisites 236:5

prescribe 98:20

prescribed 137:10

149:19

presence 41:17 95:13

151:22 176:13 177:2

present 9:6 16:11 22:3

25:8,12 98:13 105:16

129:1 150:18 183:1184:18 185:5 225:21

231:5

presentation 10:8 11:3

11:15 12:5 15:18

18:13,14 19:9 23:16

29:15 30:15 32:8

35:11 44:14 52:9

58:4,6,8,17 62:1

70:14 75:1,2 77:9

84:18 91:22 96:22

101:8,11 120:4

125:17 126:19 127:9130:5 135:20 156:4

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185:3 188:12 189:15

189:22 225:17,19

230:6,12 231:8

232:12 234:14

235:15 237:3 238:5

240:19,20 244:9

250:18 258:2 259:22

262:17 263:19 272:2

275:8 294:10 325:5

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28:7 60:5 90:1

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278:12

presented 53:2 74:20

123:4 124:2 132:22

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presents 73:10 169:19312:3

preservation 198:10

preserve 314:17

president 4:5 184:14

328:2

prespecified 83:3 89:5

230:16 232:3 233:2

237:10 268:13

pressure 285:21

315:20

pressures 315:19

presumably 118:8

221:13 314:4presumed 170:22

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pretty 107:14 158:7,15

291:11 292:15

329:16

prevent 195:4 242:8

prevention 151:6 313:4

previous 18:8 68:1

79:17 113:21 184:4

208:4 217:21 222:8

248:17 323:9previously 28:6,8

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primarily 24:19 260:14

276:15 296:15

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primary 21:17 25:1,5

25:10 33:1 34:21

35:6 36:5,9,10 37:12

37:13,14 38:5 40:12

45:3,11,18 46:5 52:2

54:20 67:9,14 70:22

75:20 76:10 82:18,20

82:22 84:8 88:14

102:17 124:4 150:6

156:11 177:10

184:20 188:18 201:9

202:4 205:14 207:1,5

207:12 209:8,17

214:14 226:14

227:13 229:14,20

231:14,16,18,19

232:2,8 233:12,14,18

234:21 236:17 237:6

237:7 239:14 240:12

240:20 242:10,18245:6 251:17 264:22

265:16 267:3 272:4

322:2 328:10 330:21

principal 32:12 52:22

principally 25:4

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prior 63:15 64:3,6

67:18 74:2 84:7 87:9

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173:19 174:10 207:1

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private 139:2

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124:12 125:11 142:8

158:18 159:9 171:17

173:6 246:11 252:1

257:17 271:21

285:13 291:16

293:14 305:19 306:4

306:6 308:9 317:12

320:6,10 322:4 326:2

problem 69:22 70:1072:8 73:8 90:14

129:17 134:12 160:3

164:11 165:1 212:11

214:2 280:14 301:10

problematic 160:8

problems 70:12 89:2

131:12 159:6 170:5

233:16 282:10

procedure 78:21 225:6

procedures 36:20

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proceed 301:21 303:10

303:20

proceeded 104:19

proceedings 300:7

301:17 302:18 303:6

process 69:8 112:14

122:21 135:15 142:5

171:13 194:17,17

199:16 200:17 269:9

275:3 279:1 289:3

processes 197:9

produce 108:16

product 10:14 19:1

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30:16 108:12,13,16108:18 136:3 141:14

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144:5 182:10 183:19

184:5 188:5 190:4

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professor 2:7 3:5,15

4:6,15 5:2,7,11 9:4

52:12,15 185:7profile 22:21 54:3

188:20 271:20 310:6

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profoundly 214:13

217:2

progenitor 208:21

prognosis 150:20

196:21

prognostic 38:20

Prognostically 147:20

program 51:1 140:19

143:12 146:1 185:15187:11,20 294:14

308:20,22

progress 19:9 23:16

27:21 29:15 32:8

39:15 41:13 44:14

52:9 58:8 75:1 84:18

91:22 101:11 120:4

125:17 127:9 130:5

156:4 171:20 184:11

189:22 225:19 231:8

241:7 244:9 250:18

258:2 259:22 262:17

263:19 272:2 294:10

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progressed 151:11

progression 49:17

progression-free 34:1

178:1

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project 18:22

projectile 285:3

prolonged 197:3

198:15 274:18

277:19 280:17

282:19 283:8

promising 33:4prompt 96:6 325:20

prone 282:16

proof 247:9

propensity 32:2

proper 41:19 96:6

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prophylactic 328:21

prophylaxis 191:20

192:13 193:14 201:1

205:12 326:10,13,14

326:18 327:3,5,14

propionic 273:2proportion 72:11 74:7

88:20 111:4 203:2

216:21 226:16

230:20,22 238:22

propose 141:17 223:16

225:10

proposed 61:10 66:3

78:10 108:3 114:10

144:21 180:16 187:6

189:4 224:19 226:10

304:2

prospective 36:2 62:2prospectively 59:18

227:3 236:3 241:20

268:2

protect 290:22

protected 311:1

protection 242:7 244:3

protein 64:16

protein-binding 274:3

protocol 20:13 36:12

36:13 42:9 44:19

49:6,12,15,17,18,22

50:4,18 61:20 64:13

67:10,12 70:6 74:16

74:19 81:19 82:4,5

87:9 96:17 101:15

104:4 108:7 113:14

115:4 126:1 148:10

149:20 171:6 188:3

199:9 201:6 202:14

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protocols 26:18

protocol-specified69:15 73:17 74:9,18

85:15 89:6

protracted 224:6protuberans 142:11

prove 60:2 317:4

proved 111:20 307:12

307:13 310:22 311:5

proven 111:17 313:7

Provenge 144:7

provide 29:9 40:1 42:3

51:13 52:5 59:10

114:14 118:10 213:1

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provided 37:10,11 38:6

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51:18 52:6 55:9

59:19 140:14 170:18

276:14,14 304:19

providing 185:1

proximal 25:7

proximate 212:7

264:22

PRs 297:9

psychosocial 329:13,15public 11:8 12:13

15:11 16:1 135:10,12

135:15,17,22 140:15

142:20 144:3,7

153:19 261:3,7,14

274:21,22 275:2,5,10

276:4 299:1 329:13

330:19 331:5 332:7,8

publication 70:19

102:15 103:18,19

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publications 176:19

309:18

published 26:22 34:2

43:20 52:21 53:7

68:4 76:4 102:22

103:7 107:19 146:14

164:2 227:21 294:22

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puke 285:2

pull 286:18 287:9

pulled 221:10

pull-up 285:4 289:6

pulmonary 25:22 26:3

31:11 32:2 33:16

69:17 147:19 150:11150:15 151:2,7,19

152:2 154:15,18,21

155:13 190:22

pulmonology 200:13

pulpit 332:10

pun 287:22

purpose 232:20 236:2

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pursue 153:7

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106:7,21,22 107:5,10126:22 127:5,14,18

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quality 59:5 70:12 72:8

90:21 92:6,13 95:16

95:18,22 96:7 117:17

121:19 122:9,12

quantitating 241:16

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47:4 104:7,12,14

105:12,21 106:7,20

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127:5,13 128:3,12156:19

quantities 251:7

271:11

quarter 271:15

queries 123:7

query 122:1,20

question 35:10,18,20

65:6 66:8 89:16 91:7

96:9,13 98:9 100:20

102:14,21 103:4,13

103:13,14 104:6

106:10 107:14,17

109:12 112:5 114:4,7114:16 115:5,11

118:6 120:18 121:14

123:16 129:4 133:15

133:15 154:5,7 155:5

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157:4 160:22 161:1

161:12 162:4,5,8,11

162:15,20 167:19

168:6 171:15 172:22

173:5 174:13 175:16

176:7 178:17 179:20

179:22 180:3 211:20240:11 241:17 242:5

244:12 245:5 246:17

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253:12 254:11

264:13,14,16 265:7

268:9,13 269:7 293:2

300:8 301:9 302:1,1

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318:9 324:11 325:6

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questions 11:7,9 12:12

12:14 15:21 21:8

23:5,8 35:9 89:13,14

89:21 90:5,6 91:5

99:7 103:6 105:19

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174:7 240:22 245:13

252:11 253:3 271:3

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quote 109:12

quoted 129:13quoting 110:6

Quynh 136:18

Q-and-A 185:17

240:16

R

R 2:1

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radiation 68:1 290:12

radiation-induced67:22

Radiographs 25:9radiotherapy 25:20

rages 286:17

raise 126:17 330:12

raised 45:2 118:16

247:17 315:13

raises 164:6

Rajeshuari 8:1 182:3

Ralph 5:1 14:14

ramification 69:6

ran 53:3 283:4 288:19

random 102:4,6 112:8

172:7 174:4 259:18

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randomized 24:5 26:8

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143:16 145:1

rate 28:12 55:13 82:10

83:1 130:22 155:13

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232:9 233:13 234:7

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rates 134:10,11 202:22

206:2 263:1 315:10

ratio 38:11 39:10 41:10

45:10 46:21 47:2,4

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79:2,5,22 80:10

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209:14,22 210:11

215:22 216:4,7,7

217:20 218:1 223:15

224:17 260:8 263:3

320:20,22 321:2

rationale 60:4 196:18

254:5 258:11ratios 38:22

rattle 90:8

ravages 290:22

ravaging 279:15

reach 116:20 272:21

323:13

reached 27:11 75:13

81:9 165:14 272:11

reaching 280:2

reactions 87:19 138:17

read 15:22 135:12

170:5,7 182:13 186:9

274:22reading 108:5 207:9

252:2

readings 148:20

readmitted 279:12

readout 313:3,4

real 24:15 159:6

164:10 225:4 271:18

282:2 289:3 320:1

realistic 143:20

realities 144:19

reality 141:12 265:10

realize 317:9realized 143:2

really 89:22 113:9

116:13 117:2 127:3

128:18 134:12

139:22 157:15,15

160:14 162:7 165:12

168:6 172:20 173:5

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280:9 283:12 305:21

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reason 74:2 87:11

111:6 126:8 130:20

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reasons 20:8 49:22

73:22 87:17 91:11

100:11 169:11

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reassemble 180:5

recall 77:18 217:8

Recalling 280:19

receipt 91:17 92:3,4

receive 27:2,4 38:3,9

39:5 40:17 41:10

44:7 45:17 48:1464:17 74:8,9,12 86:9

87:2 94:19 98:22

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recovery 140:4 177:7

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recurred 31:15 122:5

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recurrence 32:19

110:17 131:2 155:8,9

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recurrent 33:16 205:16215:14

recused 190:8

reduced 191:13 193:10

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reduction 21:12 39:13

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210:11 213:6 218:1

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reductions 188:21

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refer 61:22 226:1

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refractory 151:3

254:19 296:4

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regimen’s 216:20

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regulated 16:10 182:22regulatory 9:18 17:12

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relevance 56:16

relevant 121:16 222:20reliable 59:21 170:18

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reliving 133:14

reluctantly 147:9

remainder 58:13 70:14

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remaining 27:7 49:21

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reminds 250:5

remission 139:16 198:6

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removal 87:11,12,13

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removals 117:21

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repeated 143:22Repeatedly 141:9

replaced 193:10

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replacements 277:18

report 20:7,14 37:2

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results 21:11 28:5 31:4

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Rodriguez 4:4 14:2,2

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role 153:21 189:11

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Ron 14:10 181:14

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room 17:16,21 147:14

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287:8 288:19

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Rothman 7:7 14:19,19

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roughly 37:15 191:6

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263:2 273:7 320:21321:1,3

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run 137:2 283:3 289:9

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scan 69:16 147:18

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scared 282:6 286:11

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seats 180:14

Seattle 252:5

second 59:22 62:17

63:6 64:12 69:8 72:8

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seizures 285:17

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Seventy-six 212:2

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Shining 280:20

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telling 19:2 292:22

tells 286:10

TEMPORARY 4:9 6:1

ten 22:1 107:20 117:2

tend 130:17

tends 92:15

tenured 52:14

term 30:14 46:10 48:22

244:8

terminal 197:13

terms 98:22 121:10127:5,13,13 161:1

217:4 224:3 245:17

253:14 254:8 259:7

259:16 261:18,20

262:13 263:14,15

264:17 270:13 317:7

319:13 324:3,12

term’s 104:11

terrifying 148:17

test 19:20 47:4,16,19

78:22 79:6,8 104:11

104:15,21 125:22

128:14,15,15 177:20207:7 209:16 210:13

231:20 238:18 242:8

289:16 316:12

tested 28:22 65:7 269:8

testimony 152:5

testing 48:3 106:7

234:6 239:9 250:15

tests 83:7 127:18 220:5

220:7 298:4

Texas 4:16 9:5 145:19

181:22

textbook 312:21th 198:3

thank 15:10,16 18:10

18:11 19:10 23:14

29:13,16 32:9 52:7

58:1,2 89:12 99:5

100:19 103:16 109:9

117:12 130:4 135:1,3

136:15 140:7,9 145:3

145:4,7 153:16,17,19

155:22 160:21

165:16 166:19

167:17 169:21 171:9

173:12 178:15 179:3

179:22 180:4,6

182:12 184:6,17

189:20 190:1 225:14

225:15 231:9 238:4,7

239:19,20 240:18

241:4 242:2 244:11

258:6 260:1 261:4





Page 48

269:11 274:20 276:3

276:8 278:14,15

284:8 291:1,2 292:12

294:2,3,7,8,11

298:20,21,22 301:20

303:2,5 305:8 306:17312:9,10 313:20

318:5 324:5 331:14

333:4

thankful 331:7

Thankfully 151:19

Thanks 160:5 261:9

320:9

that’s 28:14 103:3

104:22 128:7 130:19

132:13 160:2 162:7

163:2,3 169:20

172:11 175:9 194:15

204:11,13 247:11252:11 253:17,19

255:19 256:5,15,16

259:19 265:3 266:7

268:18 283:9 284:5

284:11 291:17

296:12 298:20 308:5

311:4 312:17 313:17

326:11,22

therapy 24:18 33:11

49:7,13,13,15,19,22

50:4,8 53:18 60:4,16

63:2,3,3,6,8,20 64:2265:4,6 68:1 73:18

74:1,2,3 81:5 85:16

86:4,21 87:3,9,15

88:2 98:20 111:12

119:6,10 148:8 167:7

168:8,18 177:10

187:4 192:9 193:13

193:22 195:1,21

197:2 204:2,3 208:16

210:3 216:6,16 225:8

228:18 229:17

230:13 233:5 235:20

248:21 267:7,8 272:5

274:18 298:18 327:2

thing 100:16 126:6

150:21 152:13

178:13 194:1 242:21

244:3 247:8 270:15

306:3,8 327:17

329:19

things 121:12 128:20

129:1 134:15 153:5

159:4 172:9 198:16

210:17 214:21

230:19 247:10

258:15 259:15261:20 266:9 277:6

283:17 291:11 310:7

323:18 324:17

think 90:11,13,15 91:1

91:4 94:19 96:14

97:22 98:6 99:22

100:11,22 101:7,12

102:5,17,20 103:16

104:13 109:19 110:1

110:11,14 112:20

114:5,6,17 115:22

117:2,7,8,16 119:13

120:15,22 121:16123:20 124:8,16

128:19 129:17

130:13,20 131:3

132:16 135:2 155:5

156:17,21 157:15

159:5 160:2,5,11

161:13 162:3 163:2

163:12,20 164:2,4,12

165:1,4 166:3,5,8,11

166:15 167:3,12

168:6,10 169:2,4

171:17 173:12,22175:2,8 176:6 177:17

179:21 196:15

203:10,21 204:20

211:10,16 220:13

223:7,16,16,22 224:2

224:16 241:7 242:13

242:15,17,21 243:10

243:20 244:2 245:22

246:7,11,20 247:8,11

251:6,17 252:1 253:2

253:12 254:14 256:7

256:19 257:5,21

258:15,20 259:14,17

260:6 263:13,20,21

264:2,9,20 266:6,9

267:2 268:8 269:1,20

270:1,9 271:3,10,18

271:21 272:4 277:1

279:4,6 280:6 282:6

284:6,9,10 285:10

290:18 293:8 298:18

305:15,17,22 306:2,5

306:8,10,14,20,21

307:5,8,11,14 309:8

309:21,22 310:10,17

310:20,22 311:5,8312:20 314:12

315:10 316:7,9,21

317:6,9,18 319:19,20

320:2,5 321:10 322:5

322:11 323:12,17

326:7,8 327:4,17,19

327:20,22 329:8,17

330:10 331:5 332:11

332:15,20

thinking 162:22

third 30:1 75:16 76:8

81:15 118:15

Thirdly 110:14thirteen 24:22 70:4

thirties 256:13

thirty 37:20

Thirty-one 49:16

Thirty-three 281:7

thirty-two 74:12

Thomas 312:21

thoracic 148:15

thoracotomy 151:11

thoroughly 315:2

thought 85:20 137:3

159:4 198:5 201:16204:5 214:19 319:9

326:10,22

thousand 276:20

327:12

thousands 307:7

threatened 332:13

threatening 87:22

three 19:4 40:22 44:17

69:4 71:22 72:3 76:2

77:22 81:2 91:4

92:21 98:15,16 111:2

111:11,14 115:13

116:17,19 117:3,15

117:18 131:8 134:3

137:12 138:2 139:14

198:16 232:10

249:20 277:6 279:17

291:18 293:18 297:7

306:1 309:9,17

316:20 323:20

three-drug 35:11 61:1

99:3 112:12 115:17

thrilled 289:10

throat 285:19 286:14

throw 175:21 292:16

324:19thrown 284:21

thymic 256:10,18

thymolpoiesis 256:12

tibia 25:7 38:1 147:7

tick 172:4,15 173:8

tide 279:22

till 286:18

Tim 185:18 189:18

240:14 263:17

time 20:9,15,19 24:20

26:19 32:17,19 36:16

37:17 49:11 53:14

55:3,12 57:6 72:6,772:10,14,16,19 73:5

88:20 90:7 92:4,5

99:3 100:5 108:11,13

111:5 113:18 117:5

119:21 127:4 128:21

130:12 133:8 138:8

139:7 140:1 141:21

147:19 150:16 155:8

155:21 159:5 167:9

173:8 193:21 195:3

195:18 196:7 197:10

200:22 208:14 209:1209:6,8 212:14,18

213:1,13 229:14

231:4 232:16 234:5

235:8 237:18 244:18

245:2 249:17,20

251:13 258:10 260:9

265:11 266:2 267:7

268:15 274:18

277:16 279:18,19

280:15 281:8,10

282:2 286:14 291:1

293:1 294:1 295:5,6

296:15,17 299:19

301:11,12,13,18

302:6 306:16 311:7

312:16 315:1,7,21

316:22 323:2,9

325:11 328:3 331:18

timed 205:14

timeline 192:8





Page 49

times 187:4 273:16,16

278:19 285:5 288:6

time-to 226:14

time-to-event 132:20

133:2,6,10 202:7,12

207:5 320:11,15time-to-failure 265:9

time-to-treatment210:16 246:3 262:19

263:8 320:3

timing 45:13,15 49:8

49:10 82:1,8 85:14

110:16 113:16 117:9

167:15 168:12

232:14

tired 137:2 295:8

tissue 25:11 30:17,21

31:9 151:17 287:16

325:19tissues 31:20 190:17

title 61:14

today 13:8 21:20 22:5

23:18 24:11 26:9

29:9 55:6 136:20

139:20,21 140:18,20

141:19 143:10,15

144:1,9,22 145:8,11

146:21 151:22

152:13 153:12

159:15 164:5 168:14

172:9 185:16 186:18189:9 230:6 276:9

277:1 278:2 289:6,6

329:6 331:8

today’s 17:20 35:11

183:16 185:17

188:12 189:18

191:15

told 139:15 204:18

243:15 278:21 279:2

Tolerability 10:20 52:8

tolerable 22:8 130:14

tolerance 256:19

tolerate 281:22 296:9

tolerated 43:16 54:12

54:13 198:21 295:19

298:4 312:12

tomorrow 147:12

332:21

tonight 332:19

tool 278:6

tools 329:15

top 66:20 79:11 94:9

174:2 287:12

topic 141:8 332:9

topical 186:17 197:9

197:14 202:1 206:19207:3 220:3 228:14

235:5 238:8 253:7

271:4,22 272:4 273:9

274:18 327:2

topically 197:4

topics 58:16

Toronto 146:20

total 36:5 64:19 187:5

205:10 218:10

250:10 251:15

totality 266:6 313:11

313:11

totally 107:7 269:6touch 261:8 272:16

328:7

touched 272:10

tough 248:5

toughing 250:8

toxic 53:6 87:5

toxicities 42:8,10,12,15

43:10,11 49:18 85:12

86:2,3,20

toxicity 44:10 54:10

85:12,15 100:21

257:18,20 285:16329:1,4

to-treatment 229:15

TPN 203:6 247:20

248:2,4,6,9,15,21,21

249:2,6,11,12,13,14

279:17 285:1 289:2

292:19,19

track 283:4

tracked 249:18

tract 11:21 189:6

190:19 197:19

224:21 287:17

trade 187:6

traditional 51:3 190:18

191:2 192:20 194:19

tragedy 225:4,9

training 146:19

Tram 136:19

transcript 141:7,20

transferred 20:3 91:10

187:18 188:7

translate 264:18

translates 39:13 41:11

transparency 135:17

275:4 330:18

transparent 135:15275:2

transplant 181:20

189:2 191:12 192:8

192:20 193:10

199:10 201:1 203:22

204:10 205:13,20

209:3,7 212:1,14,15

212:18 214:1,5

215:15 217:19 225:4

230:17 232:14

235:16 245:2 247:2,4

252:17 253:18

254:21 255:5 256:12270:5,13 276:7,11,18

276:21 278:22 279:8

283:4,7 284:18 288:1

288:7 289:7 291:8,9

291:11 293:21

294:14 307:7 312:7

322:3 324:20 325:18

transplantation 6:5

184:22 186:4 190:15

254:17 295:3

transplanted 255:11

255:12 267:16transplanter 254:14

269:19 312:21

transplanting 256:14

326:1

transplants 255:22

261:20 270:2

transportation 136:20

145:9

traumatized 281:15

travel 136:6 275:16

278:10 294:20

treat 28:20,22 31:22

104:9 115:12 150:22

186:22 187:2 245:19

306:12 312:2

treated 33:13 44:4

60:14 109:3 118:17

140:2 168:3 187:17

195:10 197:7 229:10

251:1,20 317:4

treating 32:14 53:10

69:11 74:4 87:13

116:9 186:7 198:3

278:7 309:11

treatment 11:19 13:9

20:22 24:9,14 28:1128:15 31:16 33:20,22

35:15 39:15 41:13

43:6,18,21 53:20

54:15 55:15 56:16

60:2 61:12,18 63:1

65:11,13 75:9 77:15

79:6,16 80:15,20

83:7,11 85:18 86:17

87:6 90:16,20 96:20

98:13 99:9 106:12,14

116:14 127:2 139:13

139:16,17 144:15

150:8,19 151:5156:20 161:11

165:20 184:19

185:11 187:6 188:21

188:22 189:5,12,20

191:9 192:6 194:19

201:10,18 202:16,22

203:1 204:3,5,7

205:1,9,11,14 206:1

206:6,8,10,12,15

209:9,15 210:1,1,7

210:12,19 211:4,5,9

211:11,12,19 214:13215:11,12 216:15,19

217:8 218:16 220:11

220:18 221:17 222:5

222:7,10,11,21

223:19 224:20

225:12 226:15,16

230:15 231:14,18

232:18,20 233:18,21

235:8,9,10 236:20

237:20 238:17,20

239:9 241:1 242:9

243:1 244:14 248:10

249:15,16 250:5,20

251:4,10 258:7,13

259:1,4,12 262:2

263:1,3,5 266:12,17

269:22 271:4 292:5

292:13 293:9,10

295:2 296:2 306:10

307:19 308:1,16,18





Page 50

311:4 313:5,8,16

321:1 323:7 325:12

326:12 327:2 330:2

treatments 22:8 24:17

34:11 137:6 167:10

186:8 270:19 290:15treatment-emergent

316:6

treatment-related218:14,14

trembled 280:9

trends 21:17 55:7

trial 9:2 21:3 24:5

26:22 28:7,10 29:2

32:13 44:4 46:2

52:20 53:1,4 55:22

56:9,18,19,20 58:18

59:3,5,18,19,22 60:3

61:2,7,8,15,16,2262:21,22 64:20,21

65:3 67:9 69:4 70:8

84:7 98:14,14,21

99:3 101:13 109:6,7

109:15,18 114:10

134:5 139:7,9 147:3

149:6 160:8,20

170:12,21 172:1

186:3 187:13 188:3

188:14,19 189:19

202:9 203:11,12,15

203:17 207:11 208:1208:3,4 215:7,8

217:20,21 218:7,11

222:1,9,15 226:12

227:11,12,19 229:17

230:18,22 231:3

233:3 240:15 267:9

267:20 268:3,22

304:14 305:22 307:6

307:8,14 308:1,4,4

309:12,20,22 310:4,8

310:9,15 311:11

313:22 314:1 317:1

317:10 325:22 326:7

326:11,13 328:15

329:16

trials 26:8,20 28:1

32:22 33:4 42:14

43:5 84:21 97:10

131:4 188:13 190:9

190:13 191:19,21

198:19,20 199:6

200:5 217:18 218:9

225:22 226:4 228:6

228:10 229:8 230:1,2

230:3,13 234:13,17

234:18,22 235:3,9,14236:14,19 266:16

311:21 312:6 313:3,6

313:6,7,16 323:9

326:16,18 328:14

tricky 158:22

tried 137:6,15 279:21

282:5 291:18 292:7,8

292:8,9 320:12

tripeptide 58:11

tripeptide-phosphati...29:19

trivial 55:21 107:14

troubled 305:14troubling 279:5

true 100:6 101:4

104:22 110:3 113:15

122:19 172:20

196:21,22 223:16

239:10 252:12 254:6

283:5 320:20,22

321:2

truly 57:14 271:4

277:10 314:16

trust 290:14

try 57:5 91:5 118:21120:14 149:4 169:2

197:21 262:7 282:3

306:12 318:7

trying 91:2 102:9,13

112:15 132:8 173:20

258:10 261:17

266:19 268:5 295:15

tube 285:18

tubing 287:14

tumor 37:22 38:20,20

60:6,7 150:6 151:15

tumorcidal 31:4

tumors 25:5,10 31:19

36:5 67:21,22 68:2

148:16 151:3,11

turf 144:7

turn 89:17,18 178:21

189:14 218:6 300:2,5

327:15,15

turning 185:3 293:8

tutelage 256:18

twelve 33:13 74:11

179:21 313:5

twenty 27:10 39:16

53:9 55:16 56:7,13

60:19 164:20Twenty-eight 213:9

twenty-five 70:5

twice 33:13 64:17

255:10 282:1 285:20

two 24:12 27:5 30:7

35:9,22 36:1 42:15

47:7 48:12,13 49:19

50:2,5,8,16 59:13

62:3,9 63:1,10 65:18

68:13 69:1 75:5

78:17,20 79:1,14

81:22 84:6 85:4 86:5

97:4,13 99:7 101:20101:21 107:13

121:15 127:11,12

139:21 146:19 152:7

170:10 174:1,2 176:7

179:21 183:6 186:21

187:4 188:11 190:13

191:18 194:22 195:3

195:11,14 196:10

198:18 199:6 200:5

202:20 205:6 208:6,6

215:9 217:18 219:9

221:8,22 225:22226:4 227:8 228:6

229:8 230:13 232:22

234:9,11,13,17,18,22

235:2,9,12,13 236:8

236:22 238:2,3,21

241:9 246:12 250:2

263:2,5,8 271:5

277:1,18 281:9 282:1

292:16 296:16

297:10 300:12

304:11 309:8 312:6

316:9 317:21 319:4

320:2 322:22 324:10

326:17 330:16,17,20

two-by-two 48:17 49:9

159:1

two-drug 96:22

two-pill 187:3

two-year 245:8

type 32:20 82:10,22

206:17 207:2 215:3,5

217:8,12,16 233:13

234:7 235:4 237:8,13

251:5 308:19,22

322:15 330:3

types 42:10 50:8 51:2169:5

typical 31:6 37:21 38:1

43:15 92:12 121:11

typically 24:20 25:10

31:12 34:9 43:9 56:4

130:20 150:6

T-cell 221:5

U

UCSD 3:17

ulcerative 194:9 197:7

272:7

ulcers 194:16ultimate 36:14

ultimately 251:20

327:14

unable 49:18 284:20

286:5 296:8

unavoidable 143:16

unaware 20:9

unbiased 37:12

unblinding 171:3

305:4

uncertain 148:17

uncertainty 148:17unclear 82:10

uncomfortable 241:13

uncommon 60:6

uncontrollable 289:5

uncontrollably 285:2

uncontrolled 34:8

uncover 290:15

undergo 96:7 154:20

undergone 154:15

underlying 164:11

209:6 212:8 214:7

219:13 225:7 227:3

227:15 264:21 265:5underperform 168:18

underperformed 97:19

understand 53:12

94:14 102:12,20

105:2,13 107:16

111:20 124:14

135:19 143:6 152:5,6





Page 51

245:10 252:4 258:18

265:14,15 266:19

275:7 306:21

understanding 162:1

265:9 330:18

understands 290:6understood 111:9

underwent 148:5

unethical 57:16 169:14

169:16 311:8

unexpected 168:17

169:2

unfolding 144:10

unfortunate 158:22

unfortunately 156:17

256:9 270:4 299:11

UNG 9:17

uniform 233:20 321:15

uniformly 233:5unique 141:11 154:18

uniquely 145:11 262:9

unit 279:2

United 24:1 55:20 98:9

138:21 161:15

276:15

unity 47:3

universally 205:22

University 2:11 3:8,13

3:21 5:5,9,12,17 8:17

14:4,8,12,15,17

145:13,19 146:9,20149:17 181:1,9,13,18

185:8 186:5 254:13

300:14,22

unmet 10:11 23:13,15

57:21 187:22 224:5

unnoticed 142:8

unpaid 23:3

unproven 54:17

unrealistic 41:4

unrelated 16:18,22

17:2 206:19 214:2

217:12 284:17

unreported 96:5

121:22

unresectable 21:19

35:4 55:8 103:20

unresponsive 205:15

unwanted 285:8

update 40:4 55:2

118:21 122:10

updated 40:7 123:10

312:21

upper 48:12 50:5

127:11 186:22

297:20

upper-intestinal197:20

uptake 30:9,17

up-to-date 220:8

urge 294:6 313:10

Urology 2:7,9

use 26:12 34:10 39:21

49:7 50:20 55:19

56:2,4 57:7,19 65:12

78:4 88:7 99:3

108:14,18 109:4

116:15,16,19 117:3

122:9 134:7,8 140:6

143:3 160:2 161:21166:11 178:6 185:10

193:5 197:3 206:19

235:5 238:8 245:18

253:7 295:1,12,15

297:17 306:7 311:16

311:21 312:11

314:18

useful 236:10 298:18

300:20

usual 50:19 141:13

157:9 158:10,16

194:1 204:11usually 143:18 192:17

193:1 198:13 293:17

296:6 298:1 308:17

utility 190:5

utilized 32:21

U.K 8:18 25:18 27:15

100:6

U.S 1:1 19:22 25:2

27:14,19 37:16 60:9

100:7 187:17

U.S.C 16:14 17:5,5,8

17:13 183:4

U.S.C.208(b)(2) 183:9

V

valid 35:15 232:20

237:15

validated 240:19

validation 118:11

valuable 238:22

value 21:7 38:11 39:10

45:4,5,10 46:4,5,11

47:19 48:21 79:7

80:10,12 81:12,14

82:15 83:9 94:10,12

104:11 126:2,7131:17,20 132:10

152:6 157:10 158:1

175:11 202:10

207:12 209:22 210:4

210:16 231:20

233:11

valued 17:10

values 206:9 221:17,19

221:21 260:12 316:2

316:6

variability 43:2 297:19

variable 209:17 265:3

variables 210:19214:21

varied 205:19 228:6

variety 176:9 197:8

various 26:16,21 100:2

144:13 172:17 191:4

292:6

vast 126:11

ventilator 285:18

verbal 15:13 154:9

241:18 302:2 303:18

305:11 324:7

verified 93:8verify 76:18 93:2

version 220:8

versus 35:12 48:4,6

78:18,19 79:2,5,21

81:6 97:21 104:7

107:8,10 117:15,16

117:21,22 124:16

126:22 127:2 129:4

159:10 160:20 196:5

206:18 208:2,9,12

209:5,10,13 211:2,6

212:5 215:7,13

216:20 217:6,16

219:17 231:2,2

244:15 252:21

259:10 270:3 293:2

294:16 310:21

314:15

versus-host 184:20

189:21 191:9 193:1

212:10 256:5,17

267:6 292:6

vertical 39:1 210:22

viable 151:13

vial 200:8

vice 4:5 32:10Vice-Chairman8:20

victim 284:1

Vietnam 137:1

Vietnamese 138:15

view 41:18 161:3

224:15 227:4 239:10

262:3 306:3,15

viewed 71:14 213:19

viewpoint 177:13

Viral 221:2

virtually 150:11

221:21

virtue 208:16virulent 144:7

visit 288:11 315:21

visited 139:5

visitors 286:7

visits 137:18

vital 40:4

vividly 149:9 198:13

volume 199:19

voluntary 43:8 50:1

119:6

volunteers 19:19,20

218:10 274:7vomiting 87:20 194:13

199:11 204:19

249:10 277:8,9

292:14,14 312:3

vote 175:9 178:16

179:2,2,17,21 180:3

307:15 308:8,9,10

317:17 318:8,13,16

319:10 331:10

voted 322:5

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voting 2:4 3:2 4:9 6:1

171:13 178:20 180:2

317:15 318:12

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wait 132:17 162:10

327:6

waiting 289:16 317:3

waiver 17:9,13,14,18





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183:5,9,10,14

waivers 16:15 17:4

walk 137:8 243:9

286:12

walked 287:7,11

wall 284:21walls 29:22

want 13:10 28:21

29:11 90:7 98:19

103:11 106:9 114:4

116:22 117:1 124:7

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159:2 172:15 175:6

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Wednesday 1:7 147:11

week 64:17 201:12

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weight 279:18,19 280:4

281:2 292:17

Weiss 145:5,6,9 148:13

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welcoming 180:18

well-balanced 227:16well-conducted 84:7

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59:14 170:10,16

304:17

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142:8 147:10 172:13

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175:10 247:11

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319:7,11 328:3 331:1

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wide 160:2widely 28:18 47:11

166:8 186:16

wife 152:7 278:15

280:11 281:12

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Wilmot 3:12

win 82:22

wisdom 321:5

wise 106:19

wish 18:9 153:6 163:9

184:5 220:13

withdraw 54:15 119:10

withdrawal 50:1 119:6withdrawals 43:8

woman 292:3

wonder 314:14

wondered 99:13 101:2

241:15 252:2

wonderful 135:4

272:20

wondering 321:22

325:21 326:3

won’t 124:3 306:9,10

306:13

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268:10 273:17 321:5

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149:2 158:19 163:6

178:6 254:6 282:14

297:15 300:14

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worked 20:20 145:17

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working 185:14 201:12

256:8

works 31:21 242:10

world 23:20 29:3,7,8

29:10 35:17 56:20

100:3 149:11 197:6

198:3 276:16 290:21

worldwide 313:3

worried 172:21 317:2

worrying 90:18

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159:14 164:17,17

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wrenching 287:22

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183:11 236:3 245:11

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year 16:19 17:1,3 25:3

26:22 38:7 55:18,19

57:7 60:9 108:17

145:16,21 146:2,11

189:3 191:7 213:2,6

214:1,5,17 215:19

217:22 218:2 222:16223:3,5 224:3 230:4

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270:3,8 279:12

289:21 291:15

293:19 307:8 321:12

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26:18 27:6,10 28:17

32:20 34:7,22 38:16

39:16,19 40:16,21,22

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71:9 72:16,17,20,22

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Page 53

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311:7 313:2 317:21

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24:16,19 27:19 28:16

28:20 29:5,6,1132:15 35:1 37:15

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131:4 152:18,22

208:2 281:10

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you’re 89:18 132:15

133:4,6 158:19

256:19 266:16

300:12 302:10,15,19

320:1 324:15 325:21

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242:22 287:6 291:20

301:15

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zero 192:12 260:10,12

$

$10,001 16:19,22 17:3

$25,000 17:7 183:7

$5,001 17:7,10 183:6

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0.065 81:12

0.067 79:7

0.11 82:16

0.125 229:11

0.55 321:2

0.6 320:22

0.62 79:6

0.63 209:14

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231:14 234:9

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01 212:3

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60:22 61:7,21,22

62:2,21 65:8,22 68:5

75:3 77:18 85:3,5,10

87:502 210:12 226:1,1,11

226:20 227:19,19

228:8,13,19,20

229:10,14 232:4

233:17 234:16,19

235:4,10 236:13,16

237:4 238:15 257:3

271:15 314:1 322:21

0244 45:4

0245 46:5 131:17

03 202:10

034 46:6

04 46:6 126:7046 126:2

05 83:10 233:11 242:7

0525 47:19

06 46:11 104:11

065 131:20 132:10

1

1 10:5 43:11,13 45:10

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82:10,22 114:12

186:21 187:1 195:10

196:5,6 233:13 279:7

296:71.01 126:5

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1.4 72:16

1:00 180:9,11

10 55:20 65:2 70:21

121:6 124:16 125:2

135:8 147:11 150:10

172:1 174:17,18

195:7 200:11,18

202:16 215:12 229:7

234:15 248:4 249:17

257:15 258:17 259:2

260:14 289:2 291:8310:14,16,19 323:14

323:16 324:14

10-by-10 286:6

10-day 200:21 203:1

325:9

10-year-old 289:14

10:30 131:9

100 152:8 273:16 280:2

11 34:7 49:14 125:1

174:13

11:00 135:8

11:44 180:7113 296:18

118 207:12 209:16

231:20

12 10:7 33:21 64:17

121:6 125:4 136:21

193:2 259:9 291:16

12A30 17:16

12-A30 183:12

12-patient 142:13

120 321:3

127 279:18

129 188:16

13 126:19 127:6 147:16

172:3

130 206:12

136 11:8

14 10:10 68:5 117:21

15 26:2 73:18 86:13

135:7 193:2 195:7

197:11 249:3 251:1

257:4,7 261:2

15-year 139:19

15-year-old 147:4

152 72:20

154 279:18

155 72:21157 11:9

16 81:20 124:16 198:1

212:6 223:15 229:9

160 321:1

167 45:18 82:6,13

17 138:12

17-BMP 273:4,6,12,20

274:10,15

177 218:10

178 34:20 56:19

18 16:14 17:5,13

120:15 142:16

147:12 183:9 209:11213:10,14

180 286:4

183 11:11,12

185 11:14

187 11:18

19 10:13 73:18 279:11

296:20

19.4 250:22

192 12:4

1962 59:9

1970s 26:6

1975 27:17 138:191986 27:17 84:22 121:5

1987 27:18

1988 61:4

1989 52:22 147:4,11,16

1990 149:9,20

1990s 21:6

1991 137:20 138:12

187:8

1992 138:14,22 139:5

139:12,15,17,18

1993 19:21 61:9 62:8

1994 84:1

1995 70:2 227:21

1996 23:22 61:5,5 70:2

227:14

1997 61:9 62:8 81:20

84:2 107:18 145:12

163:17 291:8

1998 145:15 174:20

187:13 227:21





Page 54

1999 82:6 187:18

2

2 10:8 43:11,13 64:7,10

64:12,13 86:7,21

114:11,11,12,12,21187:4 196:6 229:10

248:15 296:8 297:2

2-by-2 46:11

2-milligram194:21

273:13

2.5 273:17 274:1

2/03 83:19

20 26:18 41:13 60:10

86:14 120:10 168:4,5

200:20 216:22 228:8

239:5 249:17 272:19

297:4

200 189:2 192:19 193:3199:19 206:5 212:1

212:11,13,21 213:10

217:8,19 226:18

229:18 232:12

237:15 270:3 313:14

2000 84:4 174:21

2001 226:13 237:1

2002 175:1

2003 20:7 23:22 28:4

37:9,10 38:6 40:12

40:18 45:3 48:9 49:2

54:20 61:6 70:1576:3,12,20,22 77:11

77:11 82:12,14 83:20

84:7 91:11,13,13

93:5,11 94:6,8 104:9

104:22 108:11

113:19 114:1 126:2,9

132:4,5,22 139:18

146:7 173:20 174:10

175:3,6 177:18

278:20 279:7 281:7

2004 20:14 28:2 56:15

2005 41:14 68:5 70:18

94:7 102:15,21 103:1103:7,17 105:2,17

107:19 109:12 141:1

141:7 144:18 164:2

188:2 226:13 282:13

295:4

2006 40:4,8,11,15,18

41:8 48:9 49:1,7 55:2

61:9 76:6,15,17

94:14,16,17,18,20

104:22 106:8 119:15

120:1,5,8,11 123:18

125:4,8,14 126:6,9

129:15 130:7 142:7171:19 172:18 175:4

175:4,5,7 188:9

2007 1:7 76:7 98:9

111:12 163:16

208(b)(2) 17:13

208(b)(3) 16:15 17:5

21 17:5,8 19:18 131:21

132:9,9 183:4 248:5

22 83:19 208:12 210:8

227:10 288:5

22-092 11:3

228 45:6,21 82:7

229 12:723 220:10 278:19

235 12:9

24 25:21 33:21 64:18

95:18 285:1

24-hour 200:7

24-week 34:4

242 12:11

244 12:12

248 84:20

25 25:14 28:12 73:20

174:14 191:22 239:5

259:9 311:6 313:225-year 311:2

26 10:15 71:7,9 73:3

84:13 124:11 125:1

174:20 257:8

2640.201 17:12 183:8

27 213:21

28 10:17 80:10 114:17

136:20 295:8 297:2

28-day 297:4

281 12:13

29 202:5 217:21

33 11:3 42:8,12 85:11

86:3,19 120:6 259:9

279:12 297:2

3-week 27:3

3:05 261:2

30 25:3 34:5,22 41:12

67:17 72:21 194:20

197:1 200:3 201:10

202:22 204:9 205:3

209:2,10 218:16

225:4 228:19 229:16

229:21 235:11

248:14 249:4,17,17277:17 297:22 313:2

313:6 323:11

30-day 205:2,11

210:20 322:16

30-year 312:13

300 289:7

300-day 289:6

309 12:15

31 84:1,2,3 174:19,21

175:1 209:13 220:20

32 73:21 213:20 292:2

329 141:19

33 281:7,9330 320:21

332 85:8

336 85:6

338 38:3

34 217:21

340 12:16 38:2

345 85:7,8

35 212:19 254:14,21

355 17:5,8 183:4

36 259:11 292:18

365 193:1

37 209:14 212:19 222:638 217:14

39 210:7,10 287:13

4

4 42:8 72:17,20,22

85:11 86:3,19 183:4

187:4 215:13 220:21

274:7

4.8 38:16 39:18

4:28 1:8 333:6

40 24:12 27:18 201:19

202:16 205:10 209:2

219:12 220:19229:22 251:9 258:19

268:11 285:5

40-some 216:11

400 60:9 273:16

41 10:19 310:13

42 208:12 227:9 286:3

43 49:21 208:9

431 296:17

44 219:11

45 218:1 223:4

46 117:21 119:5 165:10

210:11 213:5 216:11

218:1 222:8,15 289:4313:15

47 218:3

48 64:19 202:18 209:13

49 10:21

5

5 17:11 84:9 120:7,10

124:10 129:11,14,20

130:14 131:5 141:7

142:14 165:12 183:8

207:7 212:7 219:11

239:6 263:3 281:7

5/6 284:1750 34:6 40:21 55:19

60:12 84:5 85:22

129:8 196:5 204:10

204:14 205:10,15

209:9,12 210:17

211:2,8 218:18 220:6

222:7 226:15 228:4

228:18 229:15

231:15 235:10

238:20 250:21 251:1

251:9 254:22 256:11

259:13 261:22265:20,22 266:10,12

266:13,21 268:18

269:20 270:9 271:17

285:5 289:15 312:16

325:15

50-day 187:5 204:7

323:8,13

500 27:2 55:20

505 174:17

506 292:12

51 84:2 238:19 239:9

519 72:21

53 48:22 282:17530 83:21 84:5 129:9

54 210:11 215:22

217:22 286:2

55 27:7 126:5,7 206:14

217:22 292:18

310:15

56 11:4 171:17




Page 55

569 258:3

57 38:8 196:5 220:10

281:17

58 217:6,16 220:6

585 70:9

59 202:5

6

6 138:21 259:10 281:10

6:00 287:8

60 26:9 27:7 40:19,21

188:14 191:5 255:5

298:3

60-cc 287:3

60-year-olds 326:2

600 25:2 55:17

61 48:21 218:22 219:17

243:4

615 198:2062 74:15 196:3 208:2

63 46:22

645 70:9

65 150:15 208:8 210:9

255:5

66 38:7 39:7 72:5 77:6

218:21 219:17

671 71:19

677 71:1

678 34:21 36:5 37:14

49:14 56:19 68:6,16

71:1 73:1368 72:6 77:7

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7 11:7

7,000 187:17 191:6

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70 192:17 201:15 203:2

255:5 260:15 268:11

700 19:17

71 217:6,16 218:3

222:9 263:4 313:1473 11:6 216:21 282:18

74 49:14 196:3

75 25:5 60:12 126:3

76 48 20 131 17

793 85:4

8

8 11:8 83:22 187:5

199:2 215:13

8:00 1:88:30 13:2

80 25:21 41:1 55:13

57:12 116:21 120:6

124:10 129:10,13,19

129:21 131:4 165:8

192:17 196:7 204:11

206:13 210:7,15

211:6,17 222:8,11

229:16 241:1 245:7

250:21 251:14

262:20 263:1 265:9

265:20 266:5,14,21

268:9,11,17,21 269:2312:16 320:4 322:4

325:15 328:12

815 199:7

83 45:10 202:17

85 148:2

86 80:10 220:6

8727 1:11

875 186:3 187:14

188:13 202:14 205:6

223:4 226:1 227:11

227:19 228:2,9,15,19

228:21 229:2,20232:4 234:10,14,20

235:6,11 236:14

247:19 258:21,22

259:2 310:13 313:8

322:14

88 296:21

89 11:7

9

9 1:7 10:5,6 11:9 34:7

77:11 82:12 134:5,6

172:3 281:10 291:16

90 74:9,16 228:792 212:2

93 99:20

9351 61:21

95 38 12 39 11 41 2

98 70:10 126:8 293:15

293:16,19

Documents

US Food and Drug Administration: 2007-4301t1-Index