US Food and Drug Administration: 2006-4250T1-Index

8/14/2019 US Food and Drug Administration: 2006-4250T1-Index

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00.2 [1] 286:3

0.4 [1] 286:1

0.9 [1] 33:7

0.997 [1] 35:9

0.999 [1] 58:15

11 [44] 20:18 31:6,18 33:12 38:21 58:

21 66:9 69:4,17 72:2 73:18 109:9

111:16,17 113:10 114:4 143:1156:19 174:16 178:6 199:1 202:4

231:17 240:13 244:20,21,21 245:

7,10 247:4,5,6,12,16 249:5,12 250:

14 251:2,13 252:12,17,21 304:4

306:19

1,700 [1] 228:13

1.a [1] 258:6

1:05 [1] 171:12

10 [6] 19:6 101:7 104:5 117:22 217:

11 228:16

10,000 [2] 10:21 18:16

10-20 [1] 49:1

10-30 [1] 74:4

10:35 [1] 106:4

100 [14] 30:19 31:20 35:8 43:19 65:

10 87:9 120:21 123:10,20 127:2

231:11 247:14 248:22 269:7

102 [1] 236:4

1029 [1] 49:5

103 [1] 236:4

106 [1] 3:25

11 [2] 20:3 49:5

12 [27] 17:17 19:7 40:18 41:5 65:10,

19 91:19 99:21,22 116:2,7 121:20,

21 122:2,5 132:21 133:1 163:17

164:6 166:22 228:16 263:7 264:6

286:2,4 300:14 301:4

12-week [6] 40:16 64:16 92:3 168:

22 169:9 261:1412-year [1] 298:1

12:00 [1] 171:11

120 [1] 33:9

12A-30 [1] 8:6

13 [1] 310:10

13,500 [1] 217:1

14 [5] 34:18 36:13 133:13 298:17

301:4

14-29 [1] 240:13

14-year [3] 299:9,11 300:2

142 [1] 3:26

15 [11] 12:16 45:2 107:1,13 109:22

129:10 146:7,8 151:12 204:14

298:1715,000 [1] 87:7

15-20 [1] 88:2

15-minute [1] 257:22

150,000 [1] 86:13

16 [2] 3:13 166:22

17 [1] 46:13

17,000 [2] 79:3 216:22

170 [1] 108:10

174 [1] 3:28

18 [2] 148:14,15

18-gauge [1] 67:17

180 [1] 3:29

186 [1] 3:30

19 [2] 1:7 187:2

191 [1] 3:31

197 [1] 3:32

1980 [1] 50:1

1980s [1] 174:7

1985 [1] 191:5

1987 [1] 23:15

1992 [1] 23:19

1995 [2] 84:14 85:3

1996[1]

86:41997 [1] 216:20

22 [27] 37:1 38:22 46:14 58:20 66:11

67:5 69:3 73:18 94:20 109:10 114:

21 125:5 143:1 148:19 156:20

157:20 202:11 244:21,21 245:6,7

247:6 248:14,19 249:6,10 250:13

20 [7] 84:13 92:18 101:7 104:5 181:

22 204:14 313:2

20-25 [1] 66:10

20-27 [1] 64:9

20-30 [4] 54:3 57:2 74:5 274:17

200 [4] 11:2 21:7 108:10 201:2

200-250 [1] 286:72003 [1] 22:6

2004 [1] 153:20

2006 [3] 1:7 287:19 313:3

2009 [1] 168:11

2010 [1] 49:5

208,500 [1] 49:1

20s [1] 204:12

21 [1] 49:6

22 [3] 127:21 187:2 262:22

23 [2] 84:13 306:17

24 [27] 15:6 39:11 58:20 65:10 70:

11 100:7 109:10 116:3 118:9 119:

3 120:21 121:4,9,21 122:1 139:15,

16 143:2 155:11 156:19,21 157:

19,22 159:12 162:18 168:17 252:

13

24-week [4] 63:18 155:11 156:3

157:1

25-plus [1] 87:7

25-year [2] 298:2 300:2

26 [1] 50:1

2b [1] 97:6

33 [28] 12:20 38:22 58:20 66:12 69:3

73:18 101:8 109:10 114:21 143:2

148:20 156:20 157:20 167:5,11

202:11 244:21,22 245:6,7 247:6

248:3,3,14,19 249:7,10 250:133.2 [1] 22:13

3.4 [1] 23:8

3:00 [1] 237:22

30 [3] 37:19 117:20 199:11

30-80 [2] 109:14 199:1

300 [2] 34:4 301:4

300-400 [1] 58:16

33 [1] 310:9

35 [1] 17:18

35-40 [1] 204:11

36 [1] 128:5

3A4 [2] 227:15 230:5

44 [31] 3:4 20:20 21:8 70:9 72:1 73:

18 109:9 111:16 114:14 123:7,11

156:19 163:17 164:6 167:6,11,12

169:8 202:4,5,8 244:21,21 245:7,

10,14,16,20 246:13 247:5,20

4-12 [1] 118:16

4-8 [1] 37:18

4-week [1] 40:5

4.1 [1] 22:8

4.7 [1] 23:7

4:25 [1] 313:1

40 [2] 117:20 164:22

40,000 [1] 10:17

40-50 [2] 113:15 199:6

400 [3] 34:2,4 301:3

48 [11] 58:21 72:1 109:9 118:9 143:

2 155:10 156:19 168:17 192:13

252:12,21

48-week [2] 40:2 162:18

55 [1] 17:19

5-10 [1] 136:8

5-7 [2] 74:7 274:18

5-prime [1] 18:17

5.1 [1] 23:8

50 [8] 3:19 55:2 72:7 117:10 120:

21 123:8,11 238:10

50-60 [1] 174:16

50-70 [1] 231:18

500-600 [1] 20:22

5071 [1] 310:7

54 [1] 17:18

55-year [1] 299:10

56 [1] 35:1

66 [2] 3:6 20:19

60 [1] 31:860-plus [1] 286:22

600 [2] 33:21 255:21

600-700-day [1] 162:7

64 [1] 34:22

77,200 [1] 216:20

7-14-day [1] 103:11

70 [3] 31:8 299:8,10

70-75 [1] 66:8

72 [4] 32:16 35:18 40:11 155:13

72-week [1] 156:3

8

8,000-10,000[1]

22:148:00 [3] 1:8 312:4 313:3

80 [8] 71:7,8,9 87:8 116:9 176:1

191:21 199:11

80-80-80 [3] 71:13 237:9 254:12

800,000 [1] 69:6

800-1000 [1] 301:5

83 [1] 3:22

85 [4] 53:15 247:11,14 248:21

99 [1] 3:10

90 [5] 31:9 33:7,20,20 311:11

900 [2] 86:7,8

95 [2] 75:21 136:1

97-99 [1] 175:17

98 [3] 64:15 65:9 121:18

99 [1] 33:8

99.9 [2] 31:9 34:1

99.99 [1] 34:2

>>90s [1] 174:14

]]s [1] 44:21

AA-2-ALL [1] 152:8

a.m [2] 312:4 313:3

Aadult@ [1] 299:17

Aall [1] 296:18AASLD [1] 116:19

Abbott [2] 6:1 8:19

abbreviations [1] 70:18

abide [1] 219:16

ability [15] 19:9 33:4 52:21 53:3 56:

2 70:21 71:6 75:19 78:22 183:1

228:18 277:19,21 286:12 299:3

able [25] 12:3 30:5 40:8,9 105:3,15

112:9 149:18 150:22 163:16 167:

17,19 168:2 169:17,18 174:13

176:19 198:5 208:21 245:15 278:

15 280:3 302:10 304:2 305:2

abnormal [1] 26:16abnormalities [2] 188:10,11

abort [1] 274:15

aboutB-all [1] 110:14above [1] 125:18

Aboy [1] 37:7

absence [5] 75:4,10 76:8 78:6 80:

5

absolute [6] 200:4 220:8 230:20

232:2 252:7 281:6absolutely [9] 50:5 162:20 223:19

231:6 252:14 254:9 283:20 306:

22 307:4

abuse [1] 189:7

abusers [2] 99:3,4

academic [2] 7:10 309:22

academics [1] 191:3

accelerate [2] 96:7 217:5

accelerated [5] 74:2 93:14,19 224:

13 274:15

accelerating [2] 96:12 150:15

acceleration [1] 224:22

accept [2] 252:15 265:8

acceptable [7] 118:13,15 119:11,

13,17,21 138:19

accepted [1] 251:21

access [12] 8:2 85:5,12 90:14 93:

13,19 94:2 96:21 114:21 205:16

207:4 225:8

accordingly [1] 30:10

account [4] 43:7 247:19 249:16

306:12

accounting [1] 75:21

accrual [1] 308:21accrued [1] 206:10

accumulation [1] 81:7

Sheet 1 0.2 - accumulation



accuracy [1] 67:13

accurate [2] 23:5 124:14

achieve [25] 39:13 40:17 41:4 48:

6 62:5 65:7,21 67:5 71:7,12 77:22

80:5 116:1 118:1 128:1 137:2 141:

17 154:5 174:21 184:4 274:6,12

279:7 302:10,17

achieved [8] 56:18 80:3 83:10

120:10 127:21 128:5,12 163:9

achievement [1] 128:7

achieving[2]

69:2 75:8acid [1] 277:20

acknowledge [3] 9:17 108:11

154:22

acknowledges [1] 8:8

acquainted [1] 87:12

acquired [2] 287:1 290:6

acquiring [1] 279:9

across [7] 19:15 36:4 37:10 122:5

188:17 257:14 275:4

Act [5] 88:16 89:3,3 185:1 222:7

ACTG [3] 84:15 105:13 310:7

Acting [3] 2:2 3:4 8:15

Action [9] 5:4 32:13 51:11 59:3 62:

3 133:10 181:11 183:13 185:9

activation [1] 53:2active [10] 23:8 73:3 75:4 77:8 78:

7 118:14 144:5 180:11 260:1 312:

16

actively [2] 215:2 217:1

activity [7] 68:14 132:14 133:13

140:20 161:15 245:6 298:7

actual [6] 34:9,20 35:12,18 39:19277:4

actually [60] 20:1 29:6 34:17 35:4,

9,13,17,21 37:1 41:17 55:16 61:

16 65:19 67:20 68:18 84:17 85:2,

5 90:5 106:15 120:19 134:14 146:

15,19 147:10 150:13 152:14 153:

15 154:14 155:5 156:6 158:2,6160:14 172:9 175:19 182:1,6,11

194:8 205:6 206:7 213:21 214:5

215:1,5,6 220:6,18 238:7,14 241:

15 247:3 248:13 250:4 281:10

286:5 292:19 299:18,22

Acure@B-for [1] 84:22

acute [6] 22:6 26:4 45:4 50:22 181:

21 183:3

acutely [2] 182:1,16

adapt [1] 277:11

adaptable [1] 280:21

adapted [1] 278:2

adaptive [1] 60:8

adapts [1] 19:14

adazanovir [1] 301:3add [14] 14:13 130:21 152:1 158:4

176:9 224:21 225:4 228:1 235:4

240:20 281:16 282:2 301:10 307:

17

add-on [2] 159:14 262:6

added [4] 31:6 169:9 264:17 269:7

adding [12] 14:10 129:21 130:2

131:15 132:1 140:14 159:13 171:

2 179:8 193:11 252:12 255:14

addition [14] 4:14 8:4 130:20 160:

21 179:5 195:20 215:22 221:2,5

233:3 246:2 252:22 275:11,17

additional [10] 16:5 48:4 146:4

168:4,5,11 232:9 273:12 274:5

312:5

Additionally [1] 187:20

additive [1] 132:19

address [19] 9:4 70:3,4 95:19 142:

7,20 143:18 173:9 184:13 185:22

193:22 196:4 197:14 208:9 258:2

271:19 273:21 290:10 303:22

addressed[7]

88:20 185:6 190:10193:18 195:15 209:21 304:19

addresses [2] 6:15 70:8

addressing [4] 17:13 90:1 181:12

224:2

adds [3] 28:5 59:21 256:16

Adefovir [1] 272:19

adequacy [1] 170:22

adequate [16] 67:9,12 70:21 91:7

92:9,22 93:6 104:2 164:6 191:21

245:19 246:12 260:6,7 263:13,18

adequately [3] 98:16 195:12 305:

21

adherence [2] 71:4 266:21

adjourn [2] 171:10 312:3

adjourned [1] 313:2adjunct [1] 277:21

ADMINISTRATION [6] 1:2 7:16

61:20 118:13 132:20 172:11

adolescent [1] 301:4

adolescents [2] 299:15 301:8

adopt [1] 125:10

Adrian [1] 44:20

adult [11] 5:11,14 53:15 186:13,17

298:18 299:11 300:3,4,5 301:2

adults [11] 114:3 137:16 285:22

286:9,14 287:3,9,13 288:6 290:16,

22

advance [3] 76:2 282:5 298:13

advanced[16]

53:4 69:11 76:21113:19 143:11 153:12 167:5 187:

12 194:21 195:10 211:6 222:4

266:9,9 293:5 298:20

advances [2] 50:3 112:15

advancing [3] 60:1 66:19 205:3

advantage [2] 254:11 255:4

adverse [7] 76:19,20 82:1 151:18

210:17 211:1 279:19

adversely [1] 224:20

advice [3] 12:3,4 250:12

advise [2] 172:20 173:7

ADVISORY [10] 1:4 3:4 4:4 6:20 9:

18,20 52:4 106:11 172:15 186:18

Advocacy [2] 3:22 83:18

advocate [13] 77:19 78:3 187:17,20 188:12 189:21 217:20 234:10

236:19 248:1 276:20 280:13 281:

1

advocateB-we [1] 207:2

advocated [1] 216:18

advocates [1] 138:1

advocating [4] 228:7 278:5 279:5

305:2

AE [2] 252:4,8

AEs [5] 83:1 252:1 255:6,8 256:3

affect [7] 32:11 34:6 39:4 42:3 43:

3 46:17 143:5

affected [4] 88:8 91:5 98:21 188:3

affects [5] 43:2 60:5,6 267:7 286:1

affiliated [2] 186:13,17

affiliations [1] 173:20

afford [1] 78:21

African [20] 71:20 75:18 98:10,15

112:21 114:6 188:22 199:5,8 200:

16,22 201:8 302:20 304:8 306:10,

16 307:19 309:4 310:9,17

afternoon[2]

180:5 233:21age [16] 17:18 21:17 286:2,4 287:

19 289:17 291:7 292:5,8,10,11

293:19 298:19 300:13,17 301:11

aged [2] 108:21 301:4

agencies [1] 88:17

agency [17] 16:19 107:14 121:10

139:17 142:8 155:7 156:20 157:1,

3,8 170:3 171:3,9 210:14 243:15

255:21 311:15

agency=s [2] 8:6 185:17

agenda [2] 8:22 15:11

agent [39] 14:11,19 30:5 31:10 36:

14 100:15 124:12 129:21 130:2,

16,19,22 131:3,15,22 132:2,11,11,

13,20 133:2,12 140:14,19 158:22169:9,21 179:9 197:12 235:4 242:

14,16 248:2,6 252:12 253:9 256:

12,16 277:21

agent-to-agent [1] 36:10

agents [60] 14:22 19:22 29:22 38:

8 42:1 51:14,18,20 64:22 75:8 81:

13,13 94:17,20 97:7 100:13 101:3,

6 104:4 114:21 117:7 119:16 124:

8 125:8 131:6 133:7,21,22 140:2,

20,22 141:13 145:14 154:5 158:

12 159:19 160:13 161:12,19 179:

16 184:17 185:11 191:14 195:20

218:19 236:2 239:6 247:3 251:2

253:1 260:22 275:5,17,17 276:14,15 277:3 278:17 282:7,7

ages [1] 286:20

aging [3] 108:14 199:14 217:4

ago [9] 20:22 25:17 26:20 85:18

89:1 92:14 105:8 112:8 148:4

agonists [1] 12:10

agree [26] 113:21 194:2 203:15

205:14 216:9 220:11 223:18 237:

3,6,14,15,18 238:4 240:5 243:14

255:2 256:2 257:5 277:5 281:6,21

283:20 296:6 297:7 305:10 307:

15

agreed [3] 85:11 214:20 270:9

agreement [9] 115:17 116:12 122:

10 130:2 140:13 211:4 225:16244:2 311:16

ahead [11] 90:1,7 91:1 96:2,3,11

99:7 209:4 231:2 254:7 301:12

Ahold [1] 224:5

AIDS [7] 3:22 83:18 87:5 97:19 98:

4 186:13,17

aim [1] 200:21

akin [1] 235:6

Alan [1] 42:6

Albany [3] 5:15,16 10:2

Albrecht [8] 3:28 173:19,22 174:1

180:2 191:15 220:7 236:10

Albrecht=s [1] 197:17

albumins [1] 110:22

alcohol [4] 18:1 46:3 99:3 189:7algorithm [2] 20:4 166:21

algorithms [1] 19:21

allograft [1] 274:8

allow [10] 60:12 80:15 82:3 162:10

163:19 164:4,10 262:7 264:8 267:

21

allowing[1]

51:2allows [4] 56:9 81:6 164:8 182:16

almost [10] 11:2 35:9 74:7 199:3

275:15 276:6 277:3,11,18 279:1

alone [11] 11:10 100:13 101:3,6

153:7 233:13,14 286:7 289:6 292:

18 304:4

alpha [2] 11:9 72:15

alpha-2a [1] 42:1

alpha-2b [4] 41:3 42:2,5 71:2

alpha/beta [1] 59:11

already [23] 8:21 90:20 98:18,18

100:6 109:3,5 111:8 113:2 115:2

119:8 128:15 132:11 140:19 170:

19 190:9 237:18 258:8,11 262:19

280:18 287:6,7ALT [4] 53:16,21 75:1,19

Alter [41] 2:14 16:13,13 21:15 49:

21 142:18,19 146:15 150:9 151:

14 166:21 205:5,6 206:17,18 213:

11,12 215:3,10,12 216:19 245:12,

13 246:8 249:12,13 251:7 253:12,

13 254:2,12,18 303:16,17 304:7,

10 305:6,10 307:5 309:12,13

altered [3] 47:18,19 145:2

alternatives [1] 194:5

although [12] 47:9 71:1 72:3 84:8

135:18 167:16 218:9 239:22 266:

12 289:15 292:11 306:21

ALTs[1]

136:12Amany [1] 83:8

amazing [1] 50:2

amazingly [1] 280:6

American [5] 66:14 188:22 306:16

309:4 310:9

Americans [20] 66:10 71:20 75:18

98:10,15 112:21 114:7 199:5,8

200:16 201:1,9 216:21 302:20

304:8,11,19 306:10 307:19 310:

17

Amiles [1] 49:21

Among [16] 17:18 21:20 28:3 62:2

107:4 117:16 123:10 132:5 140:

13 166:14 199:1 210:1 235:15

276:15 310:17,18amongst [2] 98:4 99:5

amount [7] 31:7 91:7,12 92:22 93:

7 166:14 261:13

amounts [4] 33:5 67:19 69:5 70:

22

ample [1] 15:20

amplification [2] 25:11,12

amplify [1] 261:18

amplitude [1] 182:11

analogous [3] 131:5 242:11 282:4

analogs [3] 12:9 151:16 153:11

Sheet 2 accuracy - analogs



analogy [4] 22:10 125:9 163:2 239:

1

analyses [2] 153:4 213:9

analysis [19] 22:20,21 42:15 58:2

61:12 64:16 76:19 77:17 145:19

146:2 161:17 163:19 167:7 170:

11,11 268:11 275:7 277:22 289:8

analyzed [2] 71:18 195:9

analyzing [2] 67:11 180:21

ancestor [1] 20:8

ancillary[2]

152:12 168:8and/or [4] 13:10 81:15 131:11 170:

13

Andersen [32] 2:5 5:19,19 7:19

158:4 169:5,6 212:15,16 229:8,9

239:9,10 246:14,15 248:16,17

251:9,10 265:2,3,13 266:1 272:6,

7,19 303:2,3 305:1,7 308:5,6

Andy [1] 42:5

anemias [1] 81:1

Angeles [1] 86:7

animal [3] 96:7,9,17

Annals [1] 98:1

announcement [1] 6:14

Another [23] 33:16 103:9 115:12

122:9 128:4 131:2 152:6,7 162:21168:12 169:10 176:14 179:9 227:

2 235:4 237:20 255:14 282:18

283:1 284:4 289:12 303:14 310:

21

answer [28] 101:9 123:14 137:21

145:5,9 146:14,16 149:10,17 156:

9 157:11 159:5 167:16,19 171:3

198:5 200:7 208:1 218:11 220:6

225:14 244:10,15 248:7,10 264:

13 285:7 296:5

answers [5] 44:16 94:22 96:22 99:

7 198:21

antagonize [2] 57:15 60:22

Anthony[4]

3:30 186:12,15,16anti-HCV [1] 132:14

antibody [1] 26:5

anticipate [3] 154:4 183:5 278:15

anticipation [1] 307:18

antigen [1] 56:5

antigen-specific [1] 184:9

antihepatic [1] 282:8

antimicrobials [1] 277:12

antiretorviral [1] 260:2antiretroviral [6] 73:3 259:15 260:21 261:3 263:1 267:21

antiretrovirals [2] 260:16 264:2

antisense [1] 12:10

ANTIVIRAL [28] 1:4 3:4,10,25 4:3

6:6,10,19 29:22 51:14 59:3,19 89:21 133:13 159:14 160:5 161:1

163:4 169:21 181:8 183:7 184:17

185:10 186:3,5 282:4,5,22

antiviral-based [2] 89:18 159:17

Antivirals [4] 6:8 159:21 183:14

251:8

anybody [1] 158:11

Anyway [5] 148:10 166:11 213:19

267:1 278:4

Apelian [4] 3:29 180:3,4,7

apoptotic [1] 57:7

apparent [2] 117:15 269:20

apparently [1] 170:3

appear [5] 109:19 112:22 227:15

236:1 309:8

appearance [1] 6:17

appears [7] 19:4 24:12 35:22 46:5

103:13 132:7,13

applaud [1] 180:17

applicability [3] 7:8 66:13 100:20

applicable [2] 124:2 165:2

applicably[1]

145:21application [7] 13:8,9 215:18,19,

20,22 248:15

applications [1] 13:14

applied [1] 125:11

applies [1] 311:1

apply [7] 7:12,15 124:1 205:11

208:5 210:10 229:5

applying [1] 230:6

appreciate [3] 93:21 190:15 196:

11

appreciated [2] 156:16 185:19

approach [12] 88:7 95:3 134:6

154:18 162:22 170:2 177:20 209:

3 221:20 248:20 256:6 294:12

approachable [1] 209:14approaches [3] 185:18 216:22

264:15

approaching [1] 64:8

appropriate [20] 7:3 14:10 26:3

118:8 121:16 125:19 156:22 203:

13 207:5 209:17 213:17 239:15

245:7 248:20 265:15 276:17 278:

2 281:3 283:14 311:20

appropriately [1] 194:3

appropriations [1] 167:18

approvable [3] 132:16 248:4 257:

17

approval [94] 13:6 93:14,19 95:22

137:15 138:7 162:22 177:7,11,19,22 197:1,12,18,18 205:19 206:13,

16 208:9,10 209:22 211:19 212:8

215:21 216:4,12 217:21 218:21

224:14 225:15,19 226:6,11,11,13

227:17,21 228:9,12 230:15 233:9,

13 234:8 235:11 241:22 243:9

244:3,20 245:1,14 246:6 247:22

249:6,7 250:13 251:16 253:11,21

257:10,13,13 258:19 260:10,13

263:16 264:9,11,21 268:8 269:2

270:21 271:1 281:4 282:1 284:13,

16,17 285:19 288:9,18,22 294:2,6,

14 295:18 296:14,20 297:2,3,5

301:17 305:13,14 311:7

approvals [2] 207:16 311:5approve [2] 250:7 283:17

approved [23] 11:10 13:16 86:5

91:11 138:17 205:16,20,22 230:

10 235:10 239:3 262:22 269:10

287:15 288:1,5 289:3,17,21 290:2

295:8 296:2 299:16

approving [1] 285:8

Approximately [11] 10:17,19,21

18:16 48:3 79:3 201:2 286:1,3,6

308:13

approximation [1] 164:16

Aprior [1] 270:15

arbitrarily [2] 67:3 69:5

arbitrary [2] 41:11 166:8

area [18] 16:21 98:11 111:9,10 177:

1 187:6 192:12 196:13 250:11

252:5,8 271:18 274:9 280:17,22

282:3 285:11 301:20

areas [11] 18:22 44:14 47:16 68:1

97:21 107:5 108:2 130:5 135:20

204:12 279:1

aren=t[6]

135:21,22 195:12 207:13 226:9 307:8

arena [4] 187:6 224:7,8 280:21

argue [3] 76:11 262:12 267:9

argued [1] 89:21

arguing [3] 296:21,22 297:1

argument [8] 78:16 89:19 90:4

227:3 235:19 261:9 291:2 298:13

arise [2] 210:12,17

arising [1] 19:12

arm [5] 86:10 117:18 143:6,6 278:

21

armamentarium [1] 184:14

arms [7] 7:3 59:6 131:22 155:10,

21 266:4 278:21

around [11] 33:17 41:21 42:17 86:6 87:8 133:3 144:15 187:6 211:14

273:3 277:22

arrive [2] 244:15 246:5

arsenicals [2] 82:22 83:1

article [2] 98:1 151:5

articles [1] 135:17

articulated [3] 119:4 132:10 135:7

articulation [1] 219:15

ascertain [1] 278:10

ascites [2] 45:13 110:20

Asia [1] 20:18

Asians [1] 304:21

aside [1] 297:8

aspect[1]

32:21aspects [2] 69:1 154:20

aspiration [1] 67:18

assay [2] 34:22 41:18

assays [5] 25:8 26:8 27:2 97:8

193:1

assembly [1] 108:10

assess [3] 67:2 161:11 233:5

assessed [1] 166:1

assessing [1] 19:21

assist [1] 107:21

associated [8] 18:3 21:9 25:21 30:

15 47:19 49:17 51:4 151:7

assume [3] 43:7 161:4 300:1

assumes [4] 43:9,13,16,19

assuming [7] 146:22 191:12 206:19 228:9 252:21 297:20 298:2

assumption [4] 207:1 224:1,2

242:13

assured [1] 118:14

asterisk [1] 120:8

at-risk [1] 167:5

attack [1] 56:12

attempt [1] 57:19

attempted [1] 127:16

attempts [2] 127:21 275:1

attendance [1] 173:5

attendant [2] 11:19 109:12

attendees [1] 87:7

attention [9] 26:2 58:14 85:9 108:

3 142:4 152:15 186:9 202:4 217:

15

attract [1] 204:9

attributable [3] 22:14 210:11,12

AUC [1] 164:3

augment [3] 56:11 62:20,22

augmentation [1] 62:4

augmenting[1]

58:22author [1] 40:15

authors [1] 128:8

availabilities [1] 78:5

availability [1] 280:8

available [23] 7:22 8:2 27:2 41:1

53:17 54:8 69:19 148:6 165:16

179:2 205:22 212:18 214:17,19

218:21 232:16 244:22 260:12 262:

21 264:10,19 289:5 294:11

average [4] 88:3 113:19 114:20

194:13

aviremic [4] 274:6 279:7 282:15,

16

avoid [5] 103:20 120:5 190:7 212:

18 274:8avoidance [1] 126:17

Award [1] 9:20

aware [8] 83:3 117:9 168:21 169:

14 182:20 190:10,14 291:15

away [5] 122:12 133:1 163:21 189:

16 255:21

Awell [1] 249:21Awouldn=t [1] 125:14

axis [1] 71:22

Ayou=re [1] 136:6

BB-we [1] 270:7

B/hepatitis [1] 112:14

back [20] 4:15 28:5 38:16 41:17

106:9 132:1 157:17 165:19 166:

10,22 169:6 173:14,16 176:3 207:

19 208:18 226:19 241:4 254:19

267:14

backbone [6] 159:9 175:6 176:8

179:17 209:11 290:15

background [2] 17:1 84:11

bad [6] 47:4 104:19 108:13 258:7

272:3 279:19

balance [5] 55:20 56:18 213:7 280:

7 299:3

bar [2] 242:6 289:2

Baraclude [1] 180:15

barest [1] 261:12barrage [1] 57:17

barriers [3] 200:19 309:2,8

base [1] 40:2

based [34] 19:20 22:18 23:11,12,

21 25:14 26:6 39:13 41:9,11 48:

13 49:11 66:7 69:3,8 75:1,2 81:21

109:15 122:11,17 123:21 151:8

159:19 165:8 166:12 168:13 169:

1 180:8 187:5 233:13 236:15 250:

18 292:17

baseline [3] 40:18 113:10 269:13

bases [1] 72:14

Sheet 3 analogy - bases



basic [3] 29:12 225:21 263:14

basically [15] 40:16 106:20 113:6

116:13 125:14 128:18 134:15 137:

3 138:7 139:2 154:15 187:6 189:

13 212:16 272:20

basis [15] 12:15 66:19 71:18 75:20

136:18 141:22 150:19 156:5 180:

20 201:19 246:11 277:13 279:1

308:15 311:22

bat [1] 212:7

bathroom[1]

42:22Baylor [1] 6:2

bearing [1] 117:3

became [1] 92:14

become [11] 27:20 40:2 56:3,6 87:

11 120:9 170:14 176:3 181:17

187:10,12

becomes [5] 26:8 121:4 129:3

187:12 303:5

becoming [1] 167:11

began [3] 23:16 49:22 148:4

begin [13] 9:9,16 29:9 30:22 33:3

51:8 142:7 164:16 197:14 232:22

233:5 292:6 309:14

beginning [4] 163:12 172:19 173:

6,10beginnings [1] 47:15

begs [1] 266:19

behalf [2] 8:15 198:16

behave [4] 42:2 117:4,8 298:18

behind [1] 4:16

believe [30] 87:15 108:6 121:7 126:

5 129:3 130:10 145:12,13 150:14

151:19 170:10 172:12 175:9 176:

7 177:6 184:2,11,19 200:16 224:

16 229:1 234:6 255:15 264:16

280:17 285:6 304:17 307:1,1,3

believes [1] 172:16

Bellevue [1] 84:17

below[2]

34:21 165:10benefactors [1] 109:21

beneficial [2] 159:1 169:11

benefit [19] 124:19 128:4 134:5

142:2 146:5,6 153:21 166:17 168:

21 169:4 185:3 192:3,21 204:19

205:4 250:2 269:20 284:9,11

benefits [1] 184:5

best [6] 81:4 119:7 123:16 178:20

242:1 286:11

bestow [1] 9:19

bet [1] 299:6

bets [1] 121:22

better [22] 42:6,12 74:14 95:10

112:17 148:21 151:11 164:8 175:

4 179:5 181:1 190:1 217:9 219:14222:16 237:11 241:20 250:5 261:

6 290:17,22 298:21

between [25] 17:18 34:3 37:21 38:

7 47:16 49:5 52:8 68:16 101:21

117:5 141:11 184:21 199:11 204:

14 207:12 211:15 213:2 237:7

245:20 250:19 251:22 266:3 280:

8 294:6 312:14

beyond [3] 95:4 116:3 165:12

bias [1] 205:18

Biceglie [1] 44:20

big [7] 17:12 38:20 42:11 191:16

269:5 296:18 309:3

bigger [1] 297:2

bilirubins [1] 110:22

Bill [3] 6:5 13:1 15:17

billion [3] 49:5,6 88:16

biochemical [5] 15:5 99:18 125:6,

18 140:2

biochemistry [1] 54:7

biologic [1] 308:2

biologically[3]

144:9 297:18 298:18

biology [5] 265:22 297:21 298:3

299:8 300:21

biomarkers [1] 168:8

biopsies [6] 46:22 61:11 67:15 68:

9,16 281:10

biopsy [14] 47:1,1 54:5,8 66:17 67:

8,18,21 68:3 75:2,3 101:13,21

293:1

biphasic [2] 58:1 183:10

Birnkrant [28] 2:22 3:9 6:9,9 9:10,

15 10:6 16:18 21:11 22:4 108:13

157:14 211:3,4 214:16 215:16

216:11 248:12 250:9,11 271:4,5

288:12,13 292:4,5 300:11,12bit [23] 22:17 28:12 47:2 66:5 68:

21 84:11 85:18 98:9 100:4 112:11

132:8 158:18 163:11 207:20 208:

2 210:15,22 216:5 242:12 262:18

294:7,8 300:18

bits [1] 135:19

black [3] 188:22 307:13 311:9

blacks [4] 21:21 304:7,14 307:4

blamed [1] 94:21

Blatt [1] 66:7

bleeding [3] 45:14 110:20 167:9

blip [2] 35:18,22

blocked [1] 43:1

blocking[2]

30:20 31:4blocks [1] 30:21

blood [11] 23:18 47:18,19 53:17

57:1 160:21 183:16,20 195:14

260:6,7

bloodstream [1] 27:16

blue [3] 47:4 52:19 69:3

blunted [1] 55:1

board [3] 100:18 106:22 186:19

Bob [1] 16:11

body [2] 24:19 302:22

bolus [2] 21:17 48:14

bone [1] 127:13

boosting [1] 266:17

born [1] 24:2

Boston [2] 5:21 16:10both [45] 13:8 15:21 17:8 18:12 21:

9 32:5 36:22 41:20 48:12 50:22

55:10 57:8 71:9 72:5 87:17 111:

22 119:12 122:21 123:1,13 125:

16 155:13 156:3 172:12 177:8

188:13 191:6 208:14 233:14,21

234:7,10,19 237:4 238:4 243:20

244:12 261:18,22 262:13 266:8

267:19 268:21 281:18 302:17

bottom [1] 75:9

Boulder [1] 180:9

box [1] 265:4

Boy [1] 251:17

Branch [2] 16:15 20:6

branches [2] 20:10,12

brave [2] 119:19 197:16

breadth [1] 137:20

break [7] 83:16 89:9 106:4 142:6,

15 257:22 258:6

breaks [1] 4:13

breakthrough [1] 65:14

Brian[2]

22:16 307:6bridges [1] 47:15

brief [4] 16:21 106:5 258:4 285:13

briefly [7] 15:10 18:7 29:12 51:8

74:18 312:6,7

bring [12] 30:5 123:2 138:20 166:

10 213:1 222:7 229:12 247:14

248:17 260:20 261:10 310:22

bringing [1] 266:2

brings [1] 81:3

broad [3] 177:4 182:5 207:16

broaden [1] 225:3

broader [2] 7:8 259:19

broadly [1] 234:16

brought [7] 108:3 118:19 125:9

142:8 148:3 282:5 303:3bugaboo [1] 248:18

Building [1] 8:7

bulk [2] 107:2,12

bump [3] 25:20 26:12 169:11

burden [4] 10:15 24:13 217:6 230:

1

burst [1] 43:12

bursts [1] 57:13

button [1] 4:7

CC-specific [1] 282:7

calcineurin [1] 277:9

calculates [1] 29:17

calculations [1] 238:11

California [3] 5:12 190:18 191:3

Call [12] 3:2 4:2 19:12,17 37:15 47:

6,20 58:14 173:17 179:11 197:15

237:22

called [6] 4:4 31:18 32:8,19 116:5

152:7

came [7] 23:4 102:16 142:15 143:

16 148:6,10 190:19

camera [1] 295:7

camp [2] 113:7,16

camps [1] 113:7

can=t [23] 42:20 43:22 94:10 100:

10 101:8 124:18 128:12 143:14

149:16 189:19 217:13 240:17 241:12,18 244:15 246:3,3 260:19 261:

1 288:20 289:4,4 309:18

cancel [1] 27:4cancer [4] 149:16 180:10 195:6

222:22

candidacy [1] 74:18

candidate [1] 59:1

candidates [5] 75:7 137:15 138:7

151:12 266:16

cannot [3] 94:11 154:14 307:1

capabilities [1] 38:10

capable [3] 81:5 82:4 167:15

capacities [1] 277:8

capacity [13] 28:1 56:12 57:14 60:

18 61:9,17 62:4,9,12,21 63:6 145:

2 170:12

carcinoma [16] 21:10 45:16 48:6,

12 54:16 80:5 82:11 108:16 124:

21 154:2 166:19 167:13 168:7,10,

21 217:6

cardiovascular [1] 188:10

care [80] 11:12,14,17 13:21 14:11

49:6 51:13 59:6 70:5 73:14 75:976:3 77:8 82:5 85:19 86:2 88:15,

19 89:3,3 94:13 103:3,8 109:7

111:17 113:3 118:11 129:22 130:

20 131:4,11,21 132:2,16 134:7,8,

18 139:4 140:15,21 143:3,7,10,15

147:7 148:22 149:3,21 156:18

157:2 158:11 166:16 169:10 189:

15 207:22 209:11,13 217:17 240:

19 242:2 252:11,20 253:5 262:7

264:17 269:7 272:21 275:9,12,13,

16 276:19 278:3 287:8,12,12,13

289:5 290:4 292:22

careful [8] 124:1 153:4 170:11 210:22 242:4 259:7 295:15 296:19

carefully [5] 189:21 238:14 267:13278:14 307:22

carinomas [1] 136:4

carry [2] 128:4 188:2

cartoon [1] 28:8

case [13] 24:13 34:18 91:6 92:7 97:

21 98:2,5 181:12,18 198:11 208:1

215:5 297:9

cases [7] 31:21 49:15 123:1 125:3

154:16 163:4 272:1

catch [1] 126:7

categorically [2] 283:13,17

categories [13] 25:1 66:3 69:16

206:5 215:17 218:9 219:14 227:1

235:16 283:18 294:1 295:19 296:16

category [7] 134:17 154:21 181:8

206:7 218:19 273:7 296:10

Caucasian [1] 72:6

Caucasians [2] 71:20 304:6

cause [9] 27:19 52:21 59:7 97:18,

22 98:3 99:2 187:10 230:8

caused [1] 261:5

causes [3] 17:15 57:7 132:22

causing [3] 44:3 73:4 127:14

cautious [1] 141:12

caveat [2] 205:21 287:10

caveats [1] 67:7

CD4 [5] 55:11,20 56:1,21 60:8

CD8 [1] 55:12CDC [5] 21:14 22:7 23:6,11 24:4

cell [10] 43:16 56:2,4,5,13,18 57:859:8,20 82:5

cells [21] 30:9,11 32:1 52:10 53:2

56:7,15 57:3,18 58:9,17 60:10,11,

14 68:8,8 82:4 135:20 162:16 184:

7 246:20

cellular [6] 181:20 182:4,10,15,22

185:2

CENTER [8] 1:3 3:19 5:8 6:18 10:

2 21:22 210:6 281:16

Sheet 4 basic - CENTER



centers [8] 32:18 129:1 185:17

225:6 267:18 272:22 274:4 281:

21

certain [28] 11:18 13:17 62:14 87:

20 88:9 90:16,16 91:9,12,12 92:2

93:1,2 97:20,21 120:9 125:12 141:

2 165:10 181:2 204:8 210:20 225:

6 226:22 238:21 239:2 245:8 302:

11

certainly [36] 43:15 52:1 81:13 83:

13 99:4,16 117:8 121:14 135:8140:8 145:8 147:9 151:20 152:19

155:19 175:9 179:17,21 193:20

196:14 198:14 201:14 203:11 207:

13 209:19 210:19 216:17 277:3

280:13 285:15 291:10 292:10 293:

1 295:3 311:5,7

Chair [2] 2:2 3:4

Chairman [1] 173:22

challenge [6] 95:9,18 138:15 224:

19 236:9,14

challenges [1] 94:18

challenging [1] 97:2

Chalmers [1] 297:8

chance [4] 45:9 65:21 145:1 157:9

chances [1] 119:9change [18] 29:16 30:6 31:22 46:7

57:8 67:6 85:20,22 89:7,11 122:2

125:5 136:14 140:6 157:4 218:3

233:19 277:13

changed [4] 95:4 170:13 206:18

255:18

changes [10] 19:15 31:4 33:7 47:

19 67:4 68:17 113:10,20 140:10

277:10

changing [4] 63:5,6 234:13,14

characteristic [2] 56:21 182:5

characteristics [4] 18:7 109:16

130:19 180:22

characterizations[1]

96:1characterize [6] 98:16 102:9,20

230:2,13 261:7

characterized [10] 22:22 58:7 66:

22 177:5,8 191:19 193:17,20 219:

10 236:12

characterizes [1] 38:6

characterizing [1] 102:3

charge [1] 152:15

charges [1] 117:14

chief [1] 180:7

Child [4] 128:15 129:1,7 287:2

child=s [1] 293:14

children [24] 24:1 45:3 154:12 286:

2,3,6,7,9,12 287:15,18 288:10 290:

17 291:3,5,7,21 292:17,21 293:9294:19 295:1,7,8

choices [3] 251:22 281:17 298:12

cholestatic [1] 284:9

cholesterol [1] 104:13choose [4] 173:8 207:8,8 269:14

chosen [1] 42:13

Chronic [38] 3:15 6:22 10:20 17:

16,21 18:2 21:7 22:12 23:19 25:

19 26:14 27:5 28:16 50:13 51:1

53:14 76:22 80:20 82:2 106:19

108:22 109:3 110:6,14 118:7 129:

4,6 134:2 152:11 174:6,10 180:11,

12,15 183:3 186:8 306:16,18

chronically [3] 11:2 181:17 182:9

chronicity [2] 45:5,6

Chung [42] 2:16 7:18 16:8,8 89:19

151:4 158:1,2 159:7 163:2 209:18,

19 220:18 233:19,20 235:12,13

236:19 242:8,9 243:19 247:1,2,21

248:6 249:4 250:15,16 251:17

252:18 253:4,22 254:9 257:4,5

261:17,18 272:15 281:5,6 307:14,15

Chung=s [1] 211:5

chute [1] 102:17

Cicely [4] 2:3 3:6 5:9 6:11

Cincinnati [1] 3:19

circles [1] 47:3

circumstance [3] 162:8,14 275:

19

circumstances [1] 52:14

cirrhosis [65] 21:10 38:22 39:2 45:

6,11 46:14,18 47:6,6,8,10,12,17

48:7 54:2,11,20 55:4 66:22 69:11,

22 74:5 76:16 88:4 108:17 110:16,

17,17,18 111:2,3 114:1 124:20

147:17,22 148:20,21 194:20 195:4,8 197:9,22 198:4 201:20,20 203:

9,11,18 208:4 209:10,13,15 210:6

212:5 213:14 216:10 218:20 225:

17 232:12,14 258:11 263:22 273:

8,9 274:17

cirrhotic [12] 45:11 48:1 54:15 93:

4 136:16 145:22 152:3 153:19

168:19 209:20,21 270:9

cirrhotics [10] 78:20 80:17 88:10

137:18 150:10 153:12 208:12 222:

3 224:11 226:2

cited [1] 125:20

cities [4] 87:4,5,7 97:20

City[4]

5:5 87:3,10 98:4claimed [1] 25:6

clarification [5] 142:14 155:7 157:

11 271:3 272:15

clarifications [1] 142:16

clarify [1] 226:20

clarifying [2] 235:13 236:18

clarity [2] 155:19 211:14

class [6] 152:4 184:22 268:18 304:

3 309:10 310:1

classes [2] 185:6 276:15

classification [2] 18:9 19:16

clear [31] 20:7 22:12 33:18,22 38:3

39:11,12 40:20 53:3 55:16 56:13,

22 57:19 58:17 68:8 72:3 101:12

109:17 180:19 182:2,6,17 184:20185:5 244:15 254:10 270:5,14

294:5 297:21 301:1

clear-cut [1] 237:8

clearance [54] 28:13,14 29:15 30:

8,12,15 32:1,3,5,6,7,8,10 34:6,21

37:10,14,21 40:11 43:8,8,12,22

51:9 53:11 57:5,10,17 58:8,13 64:

1 81:1 82:6 120:5,6,12 121:3 122:

21 124:9 144:1 161:21 163:1,5,5,

9 169:3 183:19,22 184:1,16 253:3

286:17 299:15 301:1

cleared [8] 27:17 30:12 35:1,9 44:

2 162:16 242:19 293:13

clearing [2] 165:17 184:7

Clearly [33] 14:3 37:20 42:14 46:

16 73:22 74:20 80:6 95:16,22 109:

15 111:3 117:18 144:7 160:16

163:5 169:16 181:3,13,16 199:13

201:18 204:13 212:20 214:19 232:

6 239:5 253:5 258:12 259:1 263:2

265:18 274:20 277:17

clinic[2]

182:19 212:12Clinical [55] 3:14 5:22 6:20 11:14

12:17,21 13:1 21:1 37:4 39:17 41:

8,14 47:7 50:8,12 51:17,19,20 52:

3 55:5 60:2 65:16 75:16 80:15 81:

12 96:11 100:8,9 106:18 130:3

135:3 137:4 139:1 157:16 166:9

174:2 176:11 179:15 186:14,17

190:21 191:4 192:12 194:12 242:

4 245:11 250:4 253:19 266:10

278:3 281:20 282:19 300:13 309:

2 311:3

clinically [3] 47:10 140:5,10

clinician [1] 265:14

clinicians [1] 166:11

clinics [1] 88:17clock [3] 45:12 54:12 121:8

close [4] 19:21 20:5 33:21 302:13

closely [1] 85:6

closer [2] 33:11 87:9

clotting [2] 23:14,16

clue [1] 212:12

cluster [1] 69:18

Cmax [1] 277:8

Cmin [1] 164:3

co-chair [1] 186:19

co-factors [1] 114:1

co-infected [15] 189:3,5 231:21

240:12,15 260:21 261:15 262:8,

10 266:8 267:5 268:10 271:13272:5 310:7

co-infection [6] 221:16 258:18

262:1,2,13 271:21

co-infections [2] 187:16,17

co-morbidities [4] 13:12 196:2

258:3,17

co-morbidity [1] 188:5

co-pilot [1] 167:9

co-primary [1] 123:13

cocaine [1] 24:17

cocktail [1] 81:22

cohort [4] 73:6 111:15 153:22 217:

4

cohorts [3] 104:8,10 105:6

coincide [1] 58:11coinfected [21] 34:13 35:6 36:5,

18 37:2,11 38:1 46:13 72:22 73:

10 76:14 78:11 92:1,4 93:3 98:6

99:5,20 115:6 136:17 137:22

coinfection [23] 46:4 72:19 84:18,

20 87:13,16,19 88:15,21 89:2,6,8,

12 97:15 98:20 99:13 100:1 104:9,

12,17 112:8,14 114:2

coinfectionB-I [1] 104:15coli [1] 251:4collaborating [1] 105:11

collaboration [1] 105:9

collagen [2] 53:3 61:19

collagenase [2] 61:17 68:14

colleagues [4] 67:16 70:7 186:21

312:12

collect [3] 34:15,16 215:2

collected [1] 212:9

collecting [1] 97:11

College [3] 5:2,15 6:3

color [1] 306:4

Colorado[1]

180:9combination [11] 11:11,12,15 133:

11 162:19 185:11 240:3,3 244:22

249:15 252:22

combinations [4] 11:16 160:13

185:16 254:21

combine [2] 94:19 213:4

combined [6] 153:7 161:4 179:20

246:22 256:22 264:1

combines [1] 17:22

combining [2] 94:16 97:7

come [24] 9:22 16:5 17:1 26:2 42:

22 85:15,17 93:6 94:17 95:21 100:

2 105:19 122:4 155:22 162:18

165:19 169:21 203:7 208:18 219:

15 226:19 256:4 287:5 296:15comes [3] 17:17 37:6 283:15

comfortable [2] 122:16 226:21

coming [4] 176:3 230:18 273:9

285:21

commend [1] 190:12

comment [16] 9:6 114:6 145:18

155:7,14 167:21 205:11 216:7

218:7 219:17 234:20 250:10 251:

12 284:5 292:5 312:5

commentary [4] 172:2,8 196:18

232:10

commented [3] 119:18 127:18

230:9

commenting[1]

12:6comments [13] 153:2 158:3 191:1

223:21 233:16 243:22 244:1 268:

1,7 273:12 283:2 288:2 292:3

commit [1] 221:15

commitment [5] 124:7 220:8 221:

8 230:20 232:2

commitments [3] 212:14 230:11

285:4

committed [1] 177:21

COMMITTEE [52] 1:4 3:4 4:4,6,18

6:20 7:6,10 8:11,17 9:18,20 64:13

106:11 117:14 121:15 138:20 140:

9 142:11 171:10 172:15,21 173:7

178:8,12 179:4 180:17 184:21

185:5,13,21 186:6,9,20 187:4 189:6 190:9 192:10 196:20 197:4 232:

8 243:8 244:1,16 246:9 249:10

257:11 270:2 273:12 283:3 288:3

309:6

committee-wide [1] 142:17

committee=s [5] 7:1 175:21 176:

15 181:7 232:11

committees [1] 185:5

common [8] 10:22 20:8,18 75:20

109:4 187:10 247:20 268:14

commonly [4] 21:19 44:21 120:19

Sheet 5 centers - commonly



260:17

communications [2] 4:10,12

communities [2] 98:22,22

Community [23] 3:20 15:17 44:21

75:16 80:11 83:19,20 84:16 86:6,

8,21 87:6 95:7 102:11 105:17 112:

11 185:20 186:18 187:5 234:12

274:20 275:22 312:13

community-based [1] 88:18

companies [19] 44:10 85:3,11 90:

12 92:8,20 93:11 96:16 97:3 105:9,16 176:22 177:21 182:21 257:1

269:18 289:2 296:1 300:9

company [6] 8:18 172:22 180:8

214:20,22 246:4

company=s [2] 173:3 177:15

comparability [1] 79:9

comparator [4] 36:10 117:18 131:

22 139:5

compare [2] 121:13 200:22

compared [14] 55:14 59:22 69:4

73:18 117:17 132:15 134:8 163:7

183:7 252:19 265:19 286:8,14

298:2

comparison [4] 36:11,16 68:4

152:8comparisons [2] 38:7 165:22

compartment [2] 43:20 160:7

compartmentalization [1] 144:3

compassionate [2] 222:18 223:3

compelling [3] 87:19,20 197:20

compensated [30] 13:9 54:22

110:13,16,16,17 111:7 113:22

118:6 120:2 126:6 137:17 147:18,

22 197:8 202:20 203:5,9,17 208:

11 209:13,20 213:4 216:9 217:22

224:11 228:4 231:17 232:12 285:

10

competition [1] 132:15

complementary[2]

133:22 185:8complete [6] 32:15 149:17 150:22

167:7 204:15 239:12

completed [4] 211:15,18 243:10

284:1

completely [11] 62:16 78:17 122:5

151:15 223:18 225:18 228:17 231:

3 237:6 286:18 297:7

completing [1] 216:2

completion [3] 159:13 160:8 270:

12

complex [7] 10:9 16:21 31:1,15

164:18 166:5 186:7

complexity [3] 171:2 181:4 281:

16

compliance [7] 65:3,14 116:4,7253:15 310:15,17

compliant [1] 70:22

complicated [2] 203:3 221:4

complication [1] 167:8

complications [6] 49:11 88:4 108:

22 126:18 187:12 206:8

comply [1] 249:19

component [1] 60:7

components [1] 66:11

composite [1] 129:13

compound [1] 210:12

compounded [1] 246:11

comprised [1] 66:11

compromise [1] 216:18

compromises [1] 156:2

concentrate [1] 175:11

concept [7] 27:15 38:16 63:10

114:20 161:14 194:5,6

conceptualize [1] 208:22

concern [15] 103:12,16,18 118:18

121:11 130:9 135:4,7 210:16,20

228:20 234:12 259:4 277:15 290:10

concerned [8] 130:12 132:5 178:3

188:21 190:5 206:22 230:22 235:

22

concerning [2] 14:13 64:21

concerns [16] 82:17 134:20 135:8

181:9 189:11 211:7 232:17 244:4,

7,14,19 259:17 260:1 292:9 308:3

311:1

concludes [2] 142:3 196:17

concluding [2] 108:4 137:14

conclusion [2] 23:6 230:19

concomitant [2] 259:11,20

concur [1] 118:12

Concurrent [1] 134:11concurrently [1] 225:9

condensing [1] 64:14

condition [1] 145:11

conduct [2] 138:22 191:4

conducted [2] 157:16 267:18

conducting [1] 243:20

confer [1] 166:17

conference [2] 86:16 150:5

conferences [1] 86:18

confidence [6] 135:15 141:9,10

162:8 166:7 216:14

confident [2] 122:5 191:8

confine [2] 111:20 247:6

confined[2]

91:14 117:6confirm [2] 116:8 121:22

confirmation [1] 25:9

Confirmed [1] 24:7

Conflict [5] 3:5 6:12,13,15 9:8

conflicts [5] 7:14 8:9,11 173:20

191:9

confusion [1] 120:5

congruity [2] 107:4 130:6

connection [1] 173:4

consensus [10] 107:20 110:3 118:

7 131:18 143:21 226:15 232:11

246:8 273:4 275:21

consent [1] 213:17

consequence [1] 144:10

consequences [3] 110:19 205:1242:17

Consequently [3] 64:19 146:7

289:22

consider [28] 68:2 88:7 90:22 91:

3 93:8,13 95:2 96:6 99:6,9 100:10

101:3 103:12 129:7 158:5 170:7

178:12 183:13 187:4 188:13 192:

10 195:3 229:2 246:5 253:20 280:

14 294:2 308:18

considerable [2] 40:5 109:12

consideration [11] 70:1 78:3 81:3,

8 83:6 101:11 165:4 188:16 233:

15 276:2,13

considerations [2] 78:13 246:1

considered [12] 40:21 76:6 80:13

121:2 125:7,12,19 133:18 134:1

138:19 189:12 257:17

considering [4] 91:4 98:14 100:

19 110:7

consistent [1] 12:4

consolidated [1] 63:20

consortium[2]

105:8,12constant [8] 28:2 30:14,15 43:8,9,

17 57:17,18

constitute [1] 257:13

constituted [1] 115:18

constitutes [2] 176:5 245:1

constrained [1] 225:3

constructive [1] 180:18

CONSULTANT [1] 2:19

CONSULTANTS [2] 2:13 309:19

consumed [1] 276:9

Consumer [2] 2:9 16:11

contact [1] 27:18

contacted [2] 106:19 198:10

contain [3] 13:9 67:12 89:5

contend [1] 58:17contended [1] 277:7

content [1] 230:2

context [10] 164:7 172:16 209:12

256:13 263:22 264:2 269:9 294:

21,22 295:2

continue [13] 40:4 66:1 68:6 131:

3 137:3 157:7 159:12 188:18 189:

18 190:8,14 221:1 296:12

continuing [3] 45:8 112:10 167:1

continuous [1] 308:15

contra [2] 56:16,18

contradiction [1] 187:14

contraindicated [3] 127:12 134:

20 140:21contraindication [1] 79:8

contraindications [1] 75:5

contrast [2] 71:11 184:6

contravene [1] 63:2

contribute [1] 243:17

contributor [1] 24:12

control [11] 7:3 14:1 79:16 118:8119:3,20 134:10 143:6 144:4 150:

2,3

controlled [4] 78:17 79:6 105:1

218:13

controls [7] 12:20 13:20,21 42:14

118:5 139:4 192:15

controversial [2] 32:21 110:11

controversies [1] 51:21controversy [3] 58:10 100:9 244:

4

conundrum [2] 55:14 288:21

conundrums [1] 82:21

conversation [2] 187:5 264:14

Conversion [1] 68:13

convert [1] 182:14

convinced [1] 297:14

copies [2] 8:4 120:21

core [1] 18:19

corner [2] 110:5 246:20

Corporation [1] 174:3

correct [8] 124:7 155:14,17 156:5

162:20 220:10 245:3 270:6

correction [1] 19:9

correlations [1] 101:21

correspondingly [1] 243:4

cost [4] 11:20 49:4 81:17 217:7

costs [5] 48:18 49:6,6,16,17

couldn=t [1] 213:15

counseling [1] 24:14

counterbalancing[1]

90:10counterpoint [1] 151:4

country [14] 34:11 86:6 87:2,9 109:

5 199:4 202:5 204:4,8,12 306:9,

15,18 309:12

county [1] 194:19

couple [12] 48:4 85:3,10 89:19 90:

10 103:9 176:22 190:22 191:10

192:10 287:21 290:9

course [22] 25:18 39:12 59:9 76:

22 115:8 116:14 130:22 149:7

150:22 160:2 168:7 183:12,18

192:6 201:11,13 210:2 221:10

227:2 237:17 252:12 282:17

cover [4] 84:4 120:4 202:17 266:

22coverage [5] 86:17 182:5,12 234:

13,13

crafty [1] 60:21

create [3] 39:17 101:6 210:22

created [3] 39:15 41:11 178:5

creates [3] 37:20 38:10 88:6

Crippen [1] 151:6

criteria [8] 26:17 138:18 150:18

175:13 176:20 189:3 269:1 279:

13

critical [3] 50:5 226:9 264:9

criticize [1] 95:12

crop [1] 257:20

cross-inhibit[1]

56:15cross-resistance [4] 96:1 102:10,

13,21

crossover [1] 118:13

crucial [3] 51:13 94:6 299:13crushable [1] 291:8

crushed [1] 291:9

crystalize [1] 223:22

CTP [1] 140:7

CTPA [1] 152:4

cure [6] 37:21 50:22 84:18 91:18

99:15 101:7

cured [6] 51:3 84:20 100:11 104:

21 176:4 231:7

curiosity [1] 117:2

current [19] 9:4 43:22 89:3 109:7113:14 143:2,10,15 147:6 156:17

157:2 160:22 166:16 184:14 189:

14,18 207:13 290:13 312:10

Currently [14] 11:9 35:20 65:2 79:

3 82:20 122:10,16 123:21 138:17

186:20 217:12 247:3 291:16,17

curve [6] 32:18 36:11,22 37:1 169:

17 183:11

cutoff [1] 166:9

cutoffs [1] 41:12

cutting [1] 96:18

Sheet 6 commonly - cutting



cyclosporin [1] 12:9

CYP [1] 230:5

cytochrome [4] 227:15 259:6 261:

20 268:16

cytokine [5] 56:3,17 57:8 63:5 170:

17

cytokines [4] 53:1 56:10,14 63:3

cytopathic [1] 52:15

cytoplasmic [1] 144:10

cytotoxic [4] 55:12 57:7,9,15

Ddaily [6] 58:3 135:4 163:15 164:6,

12,15

damage [1] 110:9

danger [1] 264:19

dangerous [6] 208:3 209:1,5 212:

20 213:18 219:6

dark [1] 104:3

data [108] 13:9,13,15 17:15 21:14

23:3 28:17 29:6 33:17 34:9,10 39:

16,19 40:1 41:1,2 43:3 64:14 66:7

68:19 70:16 71:1,13 74:10 77:16

80:15 90:16 91:8,8,12,19 93:1,7

96:2,3,17 97:11 98:6 136:19 138:

2 144:12 146:19,21 149:2 154:15164:6 167:3,6 168:13 169:8 176:6,

10,12 177:12 182:13 205:22 206:

3,5,6 208:11 211:16 212:9,11,17

215:2 217:3 218:12,20 225:22

226:22 227:1,5,10,11,12,14,16,17,

18 229:4,10,17 230:5 234:6 243:

10 246:21 260:3,10 261:13,14

262:20 263:3,6,9,13,18,20 264:1,

10 267:2 271:6,20 288:17 292:1

294:1 305:12,14,19

dataB-we [1] 271:6

database [2] 74:11 146:2

databases [3] 97:8,12 105:20

date [4] 144:12 169:14 257:2 291:

13

David [2] 3:29 180:7

Davis [1] 49:11

Davis= [1] 41:2

day [6] 10:10 19:6 197:13 258:7

287:19 312:4

days [15] 33:9,21 34:2,4,15,18,22

35:1 36:13 38:17 58:16 92:14 133:

14 191:11 282:15

dead [1] 216:21

deal [11] 42:18 95:10 175:2 188:7189:4 192:7,9 222:21 231:14 235:

3 307:10

dealing [9] 49:7 134:14 155:1 205:

7 230:21 231:13 233:12 235:6273:2

deals [1] 195:18

dealt [4] 95:11 114:19 199:17 303:

8

death [11] 17:15 43:16 73:9 97:18,

22 98:3 187:11 213:22 218:4 220:

2 230:8

deaths [8] 10:21 22:6,14 49:1 73:8

228:13,16 261:5

debate [3] 77:7,20 228:8

debated [2] 62:17 63:21

Debra [5] 2:22 3:9 6:9 9:10 21:6

decade [2] 48:17 174:12

decades [2] 27:12 293:18

deceased [1] 152:9

decide [1] 40:3

decided [1] 140:4

decision [6] 25:4 165:5 166:12

200:5 219:19 246:1

decision-making [1] 172:13

decisions [1] 24:20

decline [14] 31:17,19 32:17,19 33:

12,15 34:5 36:11,22 164:18 165:9,9 169:17 183:18

declines [2] 159:21,22

declining [1] 35:22

decompensate [1] 74:8

decompensated [70] 13:10 49:15

76:16 78:20 80:4,17 111:2,8,9

115:9 119:19 120:3 126:3,8,10

127:10,13,20 128:15 134:16 145:

7 150:8 151:9,11 153:18 197:9,22

198:3 202:21 203:2,22 204:2,20

206:15 208:3,12 209:9,14 210:5

212:5 213:4,14 218:20 219:6,20

220:12,13 224:3,7,7 225:4,17 226:

1 228:6,22 232:1,14 233:2 258:11

263:22 270:9 273:7,8,19 274:1276:1 278:19,22 295:14 298:10

decompensatedB-it [1] 126:1

decompensation [15] 48:2 54:14

55:2 79:7 80:1 88:11 93:4 127:15

150:13 151:10 195:5 217:5 218:2

225:5 274:19

decrease [2] 49:16 61:14

decreased [4] 34:2 56:16,17 128:

7

decreases [1] 49:14

decreasing [5] 61:10 108:13 124:

19 166:17,18

decrement [1] 71:10

deeper[1]

186:6deeply [2] 155:18 161:12

defensible [1] 252:14

defer [2] 167:2 288:11

deferred [4] 14:2 118:12 134:9

139:6

deficits [2] 72:12 136:17

define [13] 26:4 64:11 65:1,2 92:9

93:21 178:9,10 236:6 243:3 252:5

253:9 281:8

defined [11] 26:14 37:20 55:9 56:8

95:22 120:19,20 123:7 147:2 150:

18 277:9

defines [1] 21:22

defining [4] 64:5 158:12 236:10

252:3definite [1] 200:5

definitely [2] 245:7 306:4

definition [8] 47:7 77:22 115:12,

14 116:6 121:4 130:14 160:12

definitional [1] 117:1

definitions [6] 107:21 110:3,4,7

116:13 159:11

definitive [4] 44:16 123:16 177:12

268:22

degree [5] 27:6 125:12 154:5 166:

7 268:21

degrees [1] 194:8

dehydrogenase [1] 62:10

delay [8] 118:15 119:3,20 206:9

230:15 243:5 260:8 288:22

delayed [1] 177:12

deleterious [2] 209:8 242:16

deliberate [1] 229:3

deliberations [1] 7:2

delineating [1] 303:6

delivered [1] 292:14

demand[1]

294:13demanding [1] 294:14

demographics [1] 188:2

demonstrate [4] 133:12 137:9

142:1 257:8

demonstrated [8] 18:12 28:17 38:

9 110:21 112:20 115:2 132:12

140:20

demonstration [1] 58:15

DEPARTMENT [1] 1:1

departments [1] 87:4

depend [2] 263:12 285:4

dependent [2] 14:12 15:8

Depending [13] 44:22 56:3 118:10

130:18 134:21 172:6 174:14 199:

11,12 207:17 238:6 251:18 308:20

depends [3] 14:3 97:19 218:22

Deputy [1] 6:7

derive [1] 42:6

derived [5] 22:20 41:2 58:2 170:9

228:4

describe [1] 191:8

described [1] 210:2

describing [3] 32:19 251:18 253:

22

deserve [1] 194:3

deserves [3] 106:16 199:22 276:

13

Design[42]

3:14 6:21 12:18,21 14:1 15:15 50:9,12 51:13,20 66:12

88:7 92:12,16,19 95:2 96:15 103:

10 105:17 129:18,20 130:4 140:

14 145:15 191:4 209:16 215:6

224:10 225:3 228:7 239:11 253:

17 254:3,3,5 255:20 267:17 276:

12 278:2 279:12 280:18 282:19

designated [1] 5:9

designed [8] 157:20 225:9 248:3

250:17,21 257:12 267:21 311:4

designing [3] 88:7 251:11 274:3

designs [13] 14:7,10 59:5 75:17

77:4,18 79:5 80:16 105:11 167:1

185:14 309:8 311:19

desirability [1] 143:22desirable [2] 167:17 219:9

desire [1] 218:10

desires [1] 242:5

desk [1] 172:3

desperate [1] 219:3

desperately [1] 214:18

despite [2] 65:3 100:8

destined [1] 152:16

detail [3] 156:10 168:3 191:8

details [1] 263:7

detect [1] 305:3

detectability [2] 34:22 144:22

detectable [2] 116:3 161:3

detection [1] 63:12

deterioration [1] 204:4

determination [1] 157:15

determinations [1] 166:20

determine [2] 41:19 172:7

determined [2] 64:16 303:1

determining [1] 20:5

devastating [1] 112:9

develop[19]

22:12 29:9,12 37:1345:12 48:5 50:21 55:22 74:5 90:8

128:14 164:13,16 165:11,13 166:

11 182:14 206:21 215:1

developed [5] 39:20 128:17 140:1

206:10 246:21

developers [2] 185:3,12

developing [5] 164:17 168:20 169:

22 182:21 290:14

Development [39] 3:8 5:22 6:21 9:

12,14 10:12 11:4 12:14 21:9 45:

16 51:15 72:17 80:12 90:14,22 91:

2 96:21 103:5 114:22 117:7 130:

11 135:6 149:16 180:13 181:4,6

185:19 186:3 189:13,22 206:7

209:7 211:10 232:19 241:9 260:19 266:16 300:15,17

developments [2] 83:9 241:21

develops [1] 190:7

devices [1] 4:11

devil=s [2] 207:2 248:1

Di [1] 44:20diabetes [2] 104:12 188:10

dialysis [2] 80:21 311:9

dictating [1] 72:14

didn=t [11] 38:2,18,20 42:22 122:4

126:14 135:20 146:15 213:22 259:

17 296:13

die [7] 27:21 28:6 45:17 213:14,19

215:7 231:20Diego [1] 5:13

difference [26] 33:10 36:20 37:8

42:11,14 52:8,22 53:1 54:2 117:5

119:2 121:7 128:21 144:20 182:9

213:2 214:13 219:3 234:15 253:

19 277:6 287:4 294:6 301:7 303:

11 305:20

differences [9] 21:3 34:4 53:3,20

71:17,19 143:9 219:5 306:13

different [72] 19:20,20 20:1,17 33:

17 36:17 38:8,8,11 41:22 42:16,

17 43:21 69:16 85:19 93:16,19,22

99:12,21 114:12 116:17 119:10

132:11 133:10 140:1 145:13,16

147:5 151:14,16 162:17,21 179:18,19 181:11,13 183:6 188:5,14,

15 207:12 208:2,5 221:12 223:17

226:12 238:12,15,22 239:8,10,11

240:6 245:21 247:10 265:18,20

277:12 279:1 287:12 294:7 295:

13,13 297:22 298:3 299:9 300:22

301:2 309:18,20 310:11

differential [10] 29:12 37:10 69:7

117:13 138:22 139:8 158:8 164:

14,21 266:3

differentiated [3] 116:18 120:2

Sheet 7 cyclosporin - differentiated



122:22

differently [4] 42:3 98:14 117:8

304:18

differing [3] 107:8 121:12 133:9

differs [1] 72:22

difficult [35] 90:7 92:17 114:10

115:4,15 134:1 143:13 144:18

174:17 178:19 187:13 189:17 192:

11 193:14 201:6 218:8 219:13

220:22 221:4 224:5 237:16 244:6

252:2,5,7,8 262:9 272:13 275:19280:17 281:19,20 283:8,19 309:

15

Difficulties [4] 3:14 15:16 50:9,12

dig [1] 186:6

Digestive [1] 3:18

direct [6] 49:5 62:22 159:21 160:5

183:13 241:8

directing [1] 77:6

direction [2] 302:2 303:18

directions [1] 122:2

directly [2] 22:14 184:22

Director [7] 3:10,18 6:8,10 16:8,

13 83:17

Director/Founder [1] 3:21

disagree [1] 203:21disappeared [2] 149:14 159:2

disclaim [1] 52:1

disclose [1] 8:13

disclosure [1] 180:6

discontinuation [1] 73:20

discounting [1] 144:15

discovered [1] 198:9

discovery [2] 169:7 224:13

discretion [1] 24:6

discuss [14] 4:5 6:20 7:2 12:14 37:

12 53:14 64:12 142:18 143:5 146:

20 155:21 157:13 178:8 205:12

discussed [17] 7:7 21:2 78:13 94:

3 98:18 144:14 151:21 190:3 197:3 234:22 246:19 258:12 273:11,

18 275:10 277:15 280:11

discussing [7] 10:11 19:2 50:8 84:

7 110:14 235:10 293:6

discussion [33] 9:16 16:20,21 25:

3 40:5 51:7 52:4 74:20 77:6 82:18

97:17 139:14 150:4 154:10 155:6

156:8 157:10 159:20 162:13 163:

11 170:5 196:20 229:22 233:21

241:5 258:8,13 264:2 272:4 298:9,

10 302:1,19

discussions [11] 8:10,20 15:20

17:2 26:21 106:11 174:8 180:18

234:22 263:12 302:4

disease [116] 5:17 17:17,21 18:323:9,20 24:13 28:22 29:2 45:11,

13,15 46:16 47:21 48:3 49:15 50:

21 51:2 52:9,16 56:22 66:20 73:8

74:15 77:1 78:22 82:10 89:17,18,

21 90:3 101:14 108:12,15,16,19

110:13,19 111:7 112:4,4,9 113:22

119:19 120:2 124:11,20 126:4,6,8

127:7,10 128:17 135:12 136:4

137:17 143:11 144:5 151:19 162:

4 163:6 174:14 175:1 180:11 181:

14 183:3 184:7 187:10 194:14,14

196:14 197:8 199:16 200:14 202:

16 203:2,16,17 204:5 212:6 218:3

219:20 222:4 223:10 228:4,6 230:

7,9,21 231:10,14,21 232:1 233:2

265:6 274:8 276:1,8 279:17 280:5

285:10,13,14 286:10,14 292:21

293:5 298:11,14,20 300:7,22 306:

21 309:11 311:2,18

diseased [1] 153:17

Diseases [12] 3:18 5:2,7,12,15 16:

14 51:5 55:15 76:21 87:15,18 95:5

disorders [2] 312:11,17

disparate [1] 114:15

disparities [1] 73:19

disparity [3] 72:7 107:5 204:9

disproportionate [1] 307:11

dissolution [1] 51:3

dissolve [1] 61:18

distinct [3] 153:21 192:19 235:20

distinction [3] 184:20 237:7 251:

22

distinctions [1] 186:2

distinctly [2] 236:9,22

distribute [1] 245:20

distribution [1] 20:16divergence [2] 20:9,22

divergent [1] 119:15

diverse [1] 188:20

divide [1] 215:16

divided [2] 113:7 236:15

Division [12] 3:10,18,25 6:6,9,10

121:6 130:10 132:22 135:8 186:4,

5

doable [1] 201:3

dockets [1] 8:1

doctors [1] 102:12

doctors= [1] 126:6

document [1] 191:10

documented[4]

76:5,9 116:4,7documents [1] 7:22

dodged [1] 146:12

doesn=t [19] 31:19 38:21 60:12 88:

22 91:13 92:1 158:19 165:17 208:

13 236:17 247:21 248:11 256:13

257:3 297:11 298:13 301:12 309:

16,18

doing [24] 32:21 63:1 94:15 96:13

103:16 128:9 137:10 142:9 154:7

177:21 178:17 201:12 220:20 241:

14 253:9 254:17 255:11 256:18

262:3 278:6 281:19 301:15 304:

21 307:3

dollars [2] 49:7 88:16

dominate [1] 66:15don=t [109] 31:21 39:1,1,5 41:4,10

43:17 46:21 53:22 79:9 84:7 92:9,

19 94:7,22 95:12 96:20,22 97:15

99:7,15 101:4 102:4 103:19 104:3

110:10 111:3 132:8 136:7,19 139:

20 143:3 145:4,8 146:13 147:4,15

153:9 155:17 157:4 164:12,20

165:11,12 168:15 176:12 177:10

178:6 191:7 193:9 194:9 195:7

197:19,19 198:11 202:5 207:10

214:3,14 220:17 221:12 223:8

224:15 230:15 231:12 233:18 242:

7 244:9 245:5,9,19 249:22 251:3

253:10 254:4 256:14 258:7 260:

11 261:4 264:5 270:11 271:16

277:14,19 278:14 282:20 283:12,

22 285:4,7 288:17,21 289:1,18

290:8 293:5 294:17 297:10,13

299:6,7 300:1,21 304:12,13 305:6

310:19 311:12 312:7

donated [1] 276:11

donation[1]

204:10done [51] 4:8 39:16 67:16 68:10

73:14 77:3 122:7 133:15 136:6

170:8 175:16 192:22 194:11 197:

10 199:8 200:21 204:2 206:13

221:7 222:9,13 226:8 236:21 237:

18 247:15,21 256:9 258:21 260:

18 261:6 264:22 270:19 276:18

280:6 283:7,14,16,21,21 285:5,5

296:15 297:2,12 298:7 306:1,3,5

309:18 311:21 312:18

donor [4] 152:9,9 214:13 223:9

dormant [1] 144:11

dose [19] 14:17 71:2,8,8 78:5 131:

10 150:15,15,21 178:22 223:4

255:7,12,22 256:4,12 278:16 299:11,17

dose-response [1] 163:22

doses [5] 73:21 150:16 184:17

275:16 301:9

dosing [4] 69:8 81:5 170:22 191:

21

dossier [1] 177:4

dots [1] 34:19

double [2] 48:22 87:10

doubt [1] 97:16

Doug [2] 7:20 261:19

Douglas [2] 2:6 5:14

down [14] 26:12 31:8 33:12,15 34:

2,3 42:22 101:7 165:19 169:11263:5 285:21 297:6 300:14

downside [1] 147:18

downstream [1] 242:17

dramatic [3] 48:19 224:10 301:7

dramatically [8] 22:5 223:17 226:

12 297:22 298:3 299:9 300:22

301:2

drift [2] 19:10,10

driven [1] 242:4

drop [11] 26:11 30:10 33:13 35:11

40:17 55:2 58:4 63:16 70:9 165:

19 282:14

dropout [1] 310:10

dropped [1] 22:5

dropping [1] 165:14drove [1] 298:9

Drs [1] 7:18

DRUG [140] 1:2,3 3:8 6:19 7:16 9:

12,14 10:11 12:14 24:18 31:20 42:

7,8 59:10 70:22 72:16 77:9 78:7

80:12 85:3,4 90:22 91:1,8,9 92:5

93:6,10 94:5,11,14,21 95:15,18

96:13 97:5 98:7 99:1 103:6 105:9,

18 115:1 118:16 138:12 155:2

162:10 164:4,9 165:21,22 169:7

172:11 185:3,6,12,19 186:3 187:

15 189:7 190:5 197:21 205:19,20

209:6 212:12 217:21 218:22 221:

5 222:7 223:4 224:18 227:20 230:

7,15 231:4 233:1,3,4 234:16,17

239:21 241:8,20 242:3 245:8 247:

17 249:1,5,15 250:20 252:16,18

255:14,15 259:18 260:19 261:3,

16 263:21 264:17,19,22 265:20

267:9 268:11 269:2,9,13,17 270:

17 277:2,13,16 278:6 283:5 285:8

288:18,22 289:2,3,16 294:10 296:9 297:10,18 299:12,12,14 300:15,

16 301:6,6,9,9,12,14 304:2 311:5

312:10,16

drug-drug [4] 259:5 260:3,16 277:

9

drug-suppressed [1] 162:1

Drug-to-drug [2] 133:17 187:21

drug=s [1] 198:2

DRUGS [99] 1:4 3:4 4:4 11:4 19:1

23:14 30:19 32:11 55:22 60:1 69:

8 89:16 90:7,8,12,14 91:3,7 93:2,

9,13 95:21 96:14,22 97:9 102:4,

21 105:10,19 133:18 138:16 142:

1 143:8 151:14,16 160:17 170:12,

18 174:22 175:13 179:18 181:8188:15 189:12 195:12 199:19 205:

15 206:21 207:1,3,22 219:1,4,10

221:2,13 223:16 227:14 239:2,4

240:20 241:12,13,18 242:6 245:5

250:17,19 251:6,11 256:4,22 257:

11,20 260:17,20,22 263:1 265:18

266:16 268:13,13,14 272:20 282:

4 284:2 285:6,20 288:20 289:21,

22 290:21 291:3 293:11 295:4,8

299:4,16 301:2

dual [1] 57:22due [10] 58:4 74:15 76:20 82:22

127:13 204:4,22 231:5 276:1,8

durability[3]

100:4 135:15 141:13durable [4] 64:7,7 135:18 163:9

duration [21] 14:18 39:3 66:20 68:

16 71:9 73:17 78:15 118:15 119:

10 121:4 131:12 135:10 156:19

170:22 192:20 224:9 251:20 252:

10,11,20 255:3

durations [4] 119:2 121:12 139:7

160:11

during [7] 4:12 32:2 39:9 160:2

181:5 183:12 185:6

dying [2] 102:18 217:12

dynamic [3] 28:7 45:8 55:20

dynamics [6] 27:15 158:15 180:20

224:18 227:6,9

Eeach [20] 7:15 10:18 19:22 20:5 35:

5 56:15 129:19 133:12 172:1 197:

6 201:2 206:4 230:3 241:6 246:20

293:22 295:19 296:1,16 305:3

eaerlier [1] 121:18

earlier [30] 43:16 55:8 69:9 108:21

109:1 116:15 118:19 123:6 125:9

126:11 134:6 135:11 153:19 154:

12 159:20 181:22 187:7,15 235:

16 236:11 259:1,5 265:6 270:9

292:20 298:10,21 306:8,14 312:

Sheet 8 differentiated - earlier



12

earliest [3] 70:12 80:14 189:1

early [56] 26:8 29:11 31:3 32:13 34:

5 35:17,17 36:21,22,22 38:17 43:

11 44:2 63:17 64:10 65:7,18 70:

10 72:3 97:6 98:16 102:14 113:9

123:16 149:17 154:18 160:4,14

166:1 168:1,10 169:7 170:15 174:

14 176:11 179:1,14 183:18 187:

18,21 192:17,18 217:10 232:19

233:2,5 241:18,20 259:3,19 260:18 262:14 268:9,18 282:8 286:19

ease [1] 253:16

easier [8] 201:4 238:7 241:1 249:1,

14,15,19 296:10

easiest [6] 201:21 202:1 221:22

264:15,18 297:17

easily [6] 206:10 212:22 234:1 251:

20 290:22 291:7

easy [4] 200:20 225:21 249:22 264:

4

ebb [2] 282:11,12

echo [1] 158:3

edges [1] 67:22

Edlin [1] 22:16

education [1] 86:22educational [1] 86:8effect [13] 38:6 61:4 81:6 100:20

104:13 160:6 167:10 170:13 203:

20 209:8 217:4 290:15 302:12

effective [13] 30:20 44:15 49:13

50:22 109:14 190:1 199:19 203:5

221:14 232:15 275:5 285:9 296:

11

effectiveness [4] 63:6 73:2,5 220:

14

effects [11] 61:1,3 132:20 153:9

196:2 200:2 222:1 255:16 268:16

290:20,20

efficacious[6]

33:11 36:13 83:4132:12 229:6,14

efficacy [43] 11:18 31:3 33:5 58:5

80:15 83:1 91:9 93:1 96:7,10,19

98:6 103:18 104:11 115:2 130:18

145:8 177:5 224:14 228:11 229:

12 248:2 251:15 253:2,9 256:1

261:14 267:7 268:19,22 269:1,7

271:13 275:3 277:4 285:22 288:

10,14 303:1,6,7,22 305:3

efficiency [6] 31:3 33:6,21 34:5

35:8 187:22

efficient [4] 31:20 184:18 205:21

267:16

efficiently [2] 38:12 44:4

efforts [4] 192:16 217:9 268:8 311:16

eh [1] 78:16

eight [2] 148:4 291:7

either [15] 25:11 143:8 144:2 147:

17 148:7 183:2 213:21 232:6 240:

6 255:6,7 256:4 259:11 275:16

310:19

elapse [1] 279:2

elect [1] 141:17

elects [1] 137:7

elegantly [1] 183:8

element [3] 211:22 224:21 248:5

elements [3] 55:1 59:13 142:13

elevated [4] 53:21 54:16 75:3,19

ELI [1] 181:19elicit [1] 181:21

eligible [2] 253:20 279:18

eliminate [4] 23:17 81:14 100:16

176:17

eliminated [2] 84:22 162:9

ELISA [1] 26:7

eloquently[1]

302:7elsewhere [1] 144:6

elucidate [1] 154:11

email [1] 86:12embark [1] 50:4

embraced [1] 143:21

emerge [1] 118:17

emergence [3] 26:5 235:7 267:11

emergency [2] 24:1,8

emerging [1] 82:20

emphasis [1] 101:17

emphasize [1] 102:2

emphasizes [1] 66:8

emphasizing [1] 18:4

employed [2] 124:12 125:2

employee [1] 8:19employees [1] 7:18

employment [1] 189:18

empty [1] 280:2

enable [1] 181:1

encephalopathy [2] 45:14 110:20

encompassed [1] 258:10

encompassing [1] 250:14

encouraged [1] 284:12

encourages [2] 172:18 173:6

encouraging [1] 309:7

end [23] 18:17 20:11 23:6 30:7 42:

8 51:18 54:11 65:7 68:10 76:9

108:3 116:13 117:11 122:6 147:

20 152:18 163:11 176:8 197:5223:9 276:1 300:18 308:15

end-of-treatment [1] 292:1

end-stage [11] 45:13,15 47:20 48:

3 108:16 124:20 128:16 135:12

136:3 187:9 311:2

endeavor [1] 11:5

ended [1] 201:1

ending [1] 200:13

endorsement [1] 118:20

endpoint [28] 47:13 51:21 54:21

67:8 77:19 121:1 122:20 124:6

127:17 129:12,13 136:2 139:11,

14 145:19 146:10 155:20 156:21,

22 157:1,4 158:8 159:11 166:20

238:6,15 239:8,10endpoints [46] 7:4 12:21 15:3,5,6

78:8,16 79:17,18 80:18 81:8 82:7,

8 99:11,12,14,16,18,18,19,20 120:

1,4,11,15 121:13 122:19 125:3,16,

18,19 128:14 129:8 140:3,3 155:

20 169:1 181:3 185:14 196:4,5

236:7 238:21 243:4 252:3 308:2

endpointsB-as [1] 196:6

ends [1] 53:4

engender [1] 82:18

England [1] 153:20

enhance [2] 183:1 309:21

enhancement [1] 184:12

enjoy [2] 145:10 161:11

enlarging [1] 225:1

enough [10] 40:8 67:12 124:11

126:8 144:21 205:21 227:17 233:

9 261:2 264:6

enroll [5] 84:19 114:10 115:5 241:1 305:22

enrolled [5] 13:1 259:16,19 291:

22 306:3enrolling [1] 246:12

enrollment [4] 115:18 291:22 309:

2 310:9

ensure [3] 172:14 189:21 267:19

ensuring [1] 308:19

enter [1] 259:9

entering [3] 50:1 62:7 174:18

entertain [1] 77:4

entertained [1] 77:5

entertainment [1] 204:1

enthusiasm [2] 131:19 141:6

entire [1] 111:21

entirely [1] 248:20

entry [3] 18:18 300:13 309:21

envelope [1] 18:20environment [3] 60:15 62:22 170:

17

Enzyme [3] 25:5,9 230:5

enzymes [3] 25:20 26:11,12

epi [1] 16:19epidemic [1] 22:1

epidemiologic [2] 27:9 245:22

Epidemiology [5] 3:11 15:13 16:2,

14 17:8

epithelial [1] 59:8

epitope [3] 55:9 182:5,12

epsilon [7] 31:2,6 33:6,18,20 58:

16 161:18

equal[5]

66:11 116:2 212:21 251:14 286:12

equals [2] 28:14 29:15

equation [4] 29:13,17 30:6 31:5

equation-based [2] 164:14,22

equations [3] 29:10 31:15 42:4

equilibrium [3] 28:15,15 29:10

equivalence [2] 248:18 255:10

equivalent [6] 249:2 250:3 252:16

255:5 256:5 290:19

era [2] 174:18 250:16

eradicate [1] 124:18

eradication [5] 120:7,10,12 144:2

175:8

error [1] 19:9

errors [1] 44:6especially [5] 170:18 209:20 222:

3 228:17 307:19

essential [1] 285:3

essentially [10] 83:5 86:20 119:6

127:2 130:4,21 132:9 176:4 210:

18 253:22

establish [3] 103:17 134:10 269:

12

established [3] 27:6 183:3 269:1

establishment [1] 26:13

esteemed [1] 186:9

estimate [4] 22:6 23:6 86:13 307:

8

estimated [3] 22:7 48:15 49:4

estimates [7] 10:18 22:13,20 23:5

48:19 54:17 64:8

etc [8] 151:17 168:9 220:15 221:18,

18 266:22 296:4,4

ethical [1] 215:14ethically [1] 214:5

ethics [4] 214:6,8,8 241:14

ethnic[12]

13:18 76:12 112:20188:20 258:15 301:22 302:4 303:

19 304:1 307:16 311:1,17

etiology [2] 17:21 21:12

ETR [1] 76:8

Eugene [3] 2:10 5:22 8:14

evaluate [2] 150:10 192:20

evaluate-Band [1] 30:22

evaluated [2] 267:12 312:1

evaluating [2] 101:14 211:1

EVALUATION [8] 1:3 6:19 25:13

155:9,12 158:5 267:8 268:15

Evelyn [1] 307:6

even [32] 6:16 11:16 42:16 43:2 47:

10 60:18 68:15 84:8 98:20 112:21

117:10,12 120:10 128:3 144:17149:13 153:21 186:2 196:8 221:

17 224:9 228:10 230:6 237:11

239:11 247:4,6 249:18 250:5 298:

16 307:1 308:17

event [3] 8:20 82:1 210:17

events [5] 76:19,20 86:8 87:8 211:

1

eventually [3] 26:5 149:8 165:15

eventuate [1] 274:17

Everson [1] 274:10

Everson=s [2] 150:14 151:5

everybody [7] 88:5 92:6 99:15

138:7 180:5 199:22 206:21

everyone[18]

17:3,7 46:18 64:18109:8 114:19 120:8 121:2 130:10

132:5 175:10 216:10 243:8 244:

18 257:21 269:2 284:13 312:8

everything [4] 85:21 105:22 246:3,

4

evidence [10] 23:20 70:13 110:8,

19 192:21 194:10 204:19 229:6

246:22 274:11

evident [1] 160:8

evoke [1] 58:13

evolve [1] 256:20

evolved [1] 39:8

EVR [3] 123:21 165:8 261:15

EVR12 [7] 124:5,14 130:8,14 134:

12 139:19 140:16exact [1] 299:22

exactly [8] 32:2 92:10 132:8 156:

12 226:21 263:2 271:16 299:19

example [12] 42:1,4 91:15 105:4

164:1 165:21 173:2 222:19 223:1

226:1 263:15 285:9

exceedingly [1] 309:4

excellent [9] 65:14 67:2 146:16

156:16 159:4 161:9 171:1 194:6

203:7

except [7] 52:14 97:19 125:17 135:

Sheet 9 earlier - except



10 140:3 178:11 275:6

exciting [3] 50:2 174:19 181:5

exclude [2] 179:2 201:5

excluded [1] 311:3

exclusions [1] 9:2

exclusive [3] 56:6,9,14

Excuse [1] 203:5

Executive [2] 3:21 83:17

exhibit [1] 35:14

exist [2] 20:11 44:1

existence[1]

55:4existing [1] 52:11

exogenously [1] 59:10

expand [1] 81:18

expanded [5] 85:5,11 93:13,18 94:

1

expanding [1] 217:8

expect [10] 38:1 107:4 135:20 160:

13 191:22 225:19 246:4 260:11

287:22 308:12

expectancy [3] 54:22 55:3 276:8

expectation [1] 262:22

expectations [1] 68:15

expected [1] 238:10

expenses [1] 173:4

expensive [1] 109:11Experience [12] 3:14 35:7 50:8,12

100:8,10 104:4,18 151:1 220:17

236:13 309:20

experienced [16] 13:7 14:5 52:2

140:18 233:11,14 234:5 235:14,

15 238:5,21 244:14 246:17 273:2

308:9 310:2

experienced-patient [1] 239:7

experienced-treatment [1] 217:

22

experimental [3] 207:21 212:4

213:16

expert [1] 198:4

expertise[1]

267:19explain [3] 29:6 39:19 72:9

explanation [3] 58:18 106:16,17

expose [1] 133:1

exposed [4] 44:22 181:17 182:1,

17

exposure [11] 23:22 24:1 25:19

144:17 164:5 242:13 297:5 299:

12 301:6,9,14

exposure-response [5] 163:20

164:9 263:14,17 264:3

express [1] 198:8

expressed [2] 135:9 306:7

expressing [1] 198:17

expression [1] 61:11

extend [5] 68:12 77:21 167:18 168:3 279:6

extended [7] 27:11 78:4 130:9,12

168:11 242:20 308:18

extending [1] 224:6

extension [1] 262:9

extensively [1] 273:11

extent [3] 169:6 206:6 256:19

external [1] 46:7extra [6] 122:2 269:18,20 270:19

294:7,8

extrahepatic [1] 51:2

extraordinarily [3] 191:18 194:4

275:20

extrapolated [1] 170:9

extremely [8] 19:5 40:19 44:9 50:

2 55:4 72:20 95:1 160:4

FF.A.C.P [1] 3:16

F4 [1] 69:12

face [2] 102:12 181:5

faced [1] 242:5

facilities [1] 4:15

facing [5] 95:18 236:14 239:21

243:15 248:13

fact [50] 23:7 25:22 27:6 30:11 35:

1 37:9 38:12 40:19 41:11 43:11

57:1 58:19 64:7 67:10 73:13 95:5

130:17 149:12,14 150:1,1 151:5

152:13 157:22 174:3 175:16 182:

20 196:11 199:3 207:5 214:11

215:14 222:22 223:6,11 231:13

232:16,21 233:7 235:5 242:19

249:13,19 250:2 256:3 257:12

289:14 299:8,10 307:7

factor [5] 70:1 194:15 195:9 259:2

293:6factors [13] 23:11,15,16 24:7 46:7,

17 61:13 144:16 160:16 221:5

267:7 286:11 287:3

fail [3] 43:6,6 137:2

failed [1] 116:1

failing [1] 14:14

fails [2] 35:13,16

failure [6] 22:6 76:22 80:20 164:2

191:15 194:3

Fair [1] 233:9

fairly [8] 17:17 33:10 41:12 160:18

166:7 231:20 242:20 249:11

fairness [1] 9:4

faith [1] 242:12

fall [2] 25:1 134:17

familiar [2] 142:22 143:3

families [2] 290:6 293:9

family [3] 62:15 230:5 287:6

far [13] 74:14 93:17 101:14 113:13

117:20 193:4 217:16 247:11,15

273:1 289:11 292:13 296:7

fare [1] 76:2

fashion [4] 96:14 205:17 297:12

300:10

fast [5] 85:13 91:3 93:9,12 228:11

fastest [3] 113:18 138:5 224:12

fat [1] 47:2

favorable [2] 82:2 128:10

favored [1] 127:17FDA [32] 2:21 3:7,10,25 6:8,10 8:3,

8,22 9:10,13 13:2 83:22 84:3 85:6,

6,12 92:20 95:21 96:16 97:2 172:

15,18 173:5 226:6,8 230:1 250:7

283:11 295:9 299:16 309:7

FDA=s [2] 7:22 8:12

fear [1] 118:19

feasibility [1] 214:7

feature [2] 165:15,16

features [2] 122:8 267:4

federal [1] 5:10feedback [2] 4:9 108:6

feel [20] 4:14 77:10 118:14 122:16177:2,3,10,14 179:17 188:6 191:8

212:3 222:5 226:21 244:12 250:

13 280:19 291:2 297:14 300:12

feeling [6] 197:7 222:11 244:11

268:7 285:16 301:17

Feigle [1] 85:14

fell [1] 154:21

felt [4] 119:15 122:5 136:11,15

fences [1] 163:7

Ferenci[1]

70:7few [17] 4:5 26:9 32:18 34:15 44:

19 55:16 90:20 119:18 126:2 168:

16 203:8 231:7 276:10 286:6 287:

22 295:1 301:10

fewer [2] 113:2 200:2

fewest [1] 222:1

fibrogenesis [6] 52:22 60:19 61:

14,15 68:13,18

fibrosing [1] 284:8

fibrosis [20] 45:20 51:3 53:4 61:10

67:3 69:9,11 128:6 147:16,17,21,

22 148:20 166:18 167:5 194:8,21

195:10 231:18 281:12

fibrotic [2] 46:6 67:20

fidelity [1] 135:5field [3] 49:22 85:2 155:18

figure [6] 97:3 105:17 133:2 243:

11 289:8 306:17

figures [5] 10:15 11:7 147:19 161:

18 162:6

fill [1] 302:14

filled [2] 302:9,16

filling [1] 12:2

final [2] 167:22 285:7

finally [12] 25:13 37:15 73:13 74:2

80:20 85:17 179:13 190:9 195:17

258:14 295:17,20

financial [7] 7:11 8:22 9:5 172:21

173:2,8,9find [12] 27:5 140:10 179:3 200:15

218:8 219:12 249:13 251:15 254:

5 261:12 272:7,11

finding [4] 47:12 135:19 236:11

308:15

findings [1] 185:4

finds [3] 69:17 73:8 74:11

fine [2] 121:20 297:15

firm [1] 9:5

firms [1] 8:21

First [51] 4:6 32:15,16 34:15,18 35:

18 36:12,12 40:15 51:8 58:3 59:

16 67:9 84:12,18,19 86:8 104:16

111:6 116:7 119:6 126:9 129:20

147:7 159:21 169:8 174:5 198:14199:13 200:12 201:16 203:1 213:

20 218:18 237:3 239:4 241:7 256:

9,11,18 257:20 260:15 274:13

276:5,11 279:22 282:6,10,15 283:

11 297:9

Fish [17] 2:6 5:14,14 7:20 9:21 10:

2,5 166:12,13 216:6,7,8 258:22

292:15,16 310:20,21

fit [1] 44:2

fits [1] 218:7

five [21] 11:9 27:7 48:4 54:14,17

55:3 87:8 92:14 129:19 137:11

141:12 142:1 172:5 175:17 176:2

186:12 241:11 288:7 289:5 292:8

297:5

five-year [1] 126:12

fixed [6] 37:22 39:14 43:10 45:7

71:2 157:19

flat [3] 191:22 193:4 308:3

flavivirididate [1] 62:13

flavivirus [1] 62:15

flaviviruses[1]

18:10fleshy [1] 67:21

flexibility [2] 208:4,8

flip [2] 33:16 163:13

flow [3] 47:18,20 195:14

focus [11] 38:15 94:4 111:18 152:

15 174:3 176:14 181:8 202:3 217:

14 301:19 303:10

focused [1] 147:16

focuses [1] 174:20

focusing [3] 114:4 195:20 302:3

folks [3] 136:21 141:1 308:1

follow [7] 104:8,10 136:12 186:5

261:9 286:6 293:18

follow-on [1] 257:19

follow-up [22] 7:5 12:22 80:6,7 82:12 100:7 104:1,2 120:22 131:7,8

135:14 136:6,8 137:1,6 141:11,16,

18 155:12 156:14 168:1

followed [6] 15:14 26:22 105:5

136:19 157:21 168:5

following [17] 6:14 7:17 12:7 25:

19 27:7 39:16 43:11 45:4 115:14

154:19 155:9 169:2 171:8,19 172:

1 193:2 273:19

FOOD [4] 1:2 7:16 172:11 214:14

forced [1] 275:15

forecast [1] 207:11

foreign [1] 155:19

forever[1]

158:20forget [1] 312:2

forgiveness [1] 210:14

forgotten [2] 237:20 239:19

form [7] 28:8 62:9,12 106:10 107:2

132:10 257:17

Forman [1] 74:10

formation [1] 43:10

former [1] 312:10

forms [1] 19:11

formula [1] 206:20

formulation [3] 290:12 291:4 292:

13

forth [1] 196:2

forthcoming [4] 68:11,19 153:6

278:3forums [2] 86:6 87:6

forward [9] 17:12,13 21:17 50:11

101:18 102:6 186:3 229:2 266:12

found [3] 44:10 84:12 253:18

foundation [1] 263:12

founded [1] 84:13

founder [1] 83:17

four [16] 13:11 48:3 64:20 70:13

86:1 89:1 92:14 103:2 137:11 141:

22 142:12 149:9 166:4 236:3 282:

15 301:22

Sheet 10 except - four



four-week [2] 166:8 227:5

fraction [1] 131:3

frame [3] 229:4 242:7,21

framework [1] 38:11

frankly [2] 290:5 291:6

free [3] 4:14 153:9 183:16

Freedom [1] 8:6

frequency [5] 42:10,10 57:2 194:

20 307:20

frequent [2] 141:16 166:6

frequently[2]

203:12 278:13Friday [1] 313:2

Fried [1] 40:15

front [7] 157:20 196:10 199:10 214:

10 215:15 245:8 299:1

Frost [1] 49:20

full [11] 86:18 137:19 150:22 180:6227:17 256:12 263:3 280:2,3 302:

13 305:3

full-blown [1] 271:12

fully [1] 307:15

function [6] 110:21 126:18 127:14

128:19,20 204:21

functional [3] 14:14 18:20 47:5functions [1] 79:22

fundamental [2] 161:9 162:12fundamentally [2] 145:22 161:20

funded [3] 191:6 194:18 234:13

further [13] 17:1 33:13 40:20 83:6

114:15 141:11,17 151:22 154:11

199:15,16 247:5 295:16

futility [2] 40:21 41:4

future [8] 50:6 154:9 176:7 185:5

190:14 229:17 244:8 257:2

fuzzy [1] 211:17

GGalveston [1] 16:15

Gary [2] 41:1 49:10

gate [1] 239:5

gathering [2] 172:13 211:20

gauge [1] 70:17

gave [1] 306:17

gemischt [1] 191:17

gender [4] 201:12,13 308:18,19

genders [1] 188:13

gene [2] 56:8 61:12

general [17] 7:12,13,17 8:10,18 16:9 44:5 114:8 130:1 140:13 195:9

197:7 205:10 211:13 212:19 244:

2 273:4

generalizable [2] 207:11,14

generalize [2] 218:8 219:13

generally [5] 38:19 47:3 112:3

287:5 293:10generate [1] 44:15

generated [1] 34:17

generating [3] 36:19 44:11 82:4

generation [3] 26:7 50:4 256:17

genetic [3] 72:14 303:11 311:22

genome [2] 18:16 25:15

genotype [58] 13:11 20:12,19,19

25:14 38:21,22 58:20,21 66:9 69:

4,17 72:2 109:15 111:16,17 112:

22 113:10 114:4 118:10 174:16

188:2 199:12 202:8 229:15,16

231:17 240:13 244:19,20,21,21,21

245:14 246:13,18 247:4,5,12,16,

20 248:3,3 249:5,6,10,12 250:8

251:2,13 252:11,17,21 257:10,12,

14 304:4 306:19

genotypes [31] 18:11 19:17 20:1,

2,3,16 66:5,11,12,15 69:3 73:17

75:20 109:9,10 111:21 114:3 137:

21 143:1 148:19 188:1 199:1 202:

3,4,11 245:6,9 250:14,18 251:11

257:15

gentlemen[1]

174:1genuine [1] 135:6

gets [7] 53:12 64:18 94:21 161:9

228:17 234:15 240:18

getting [13] 96:14 220:4 232:3 238:

17 246:15 267:1,14 272:22 294:6,

16 296:8 298:21 310:2

GI [1] 290:1giong [1] 145:16

give [29] 10:1 25:8 33:3 39:6 44:16

59:10 75:14 84:11 93:10 107:7

119:7 122:1 124:5 131:6 142:10

149:16 154:3 157:8,12 165:20

172:1 195:6 208:21 210:21 216:

14 226:6 268:20 280:16 285:12

given [18] 26:13 27:22 33:4 41:1946:7 47:9 74:7 139:16 149:9 156:

2 158:13,18 261:15 266:18 276:6

301:6 307:19 308:3

gives [1] 36:10

giving [4] 92:11 119:14 167:15

185:22

glad [2] 83:22 84:3

glass [1] 280:2

gleaned [1] 126:15

global [1] 11:6globally [1] 10:17

Globe [1] 3:29

GlobeImmune [2] 180:8,13

goal[12]

100:14 120:5,11 122:21175:8,11 176:16,18 182:22 274:

12 291:22 295:21

goals [6] 50:20 107:6 126:16,21

302:10,17

god [1] 64:4

gold [1] 101:13

Gordon [1] 26:19

Gordon=s [1] 28:18

gosh [1] 123:2

got [6] 105:10 131:1 152:10 177:22

226:14 240:1

gotten [1] 155:2

Gould [1] 3:17

government [1] 7:18

grade [4] 67:2,13 69:12 125:5graft [2] 282:6,10

grant [1] 223:5

granted [1] 309:14

graph [1] 21:22

graphic [1] 181:18

gratigied [1] 153:13

great [14] 27:6 28:1 82:18 111:10

130:9,17 135:15 139:19 192:7

204:9 222:21 228:8 240:19 307:

10

greater [15] 11:15 19:6 26:14 36:

12 45:9 56:11,12,20 67:6 110:10

116:1 136:1 138:6 151:12 234:3

greatest [10] 66:13 75:2 78:21 113:

11,16 179:22 207:4 266:10,11

274:21

greatly [3] 185:12,19 301:10

green [3] 55:2 65:13 69:13

Greg [3] 150:14 152:14 274:10

Greg=s [1] 152:2

grew [1] 297:8

grey[1]

292:12groundwork [1] 261:21

Group [112] 5:5 21:16 22:21 26:22

28:18 37:11 38:2 46:11 47:14 52:

5 65:2,3,6,9,12 66:1 69:21 72:6

75:2 79:7,12,16 80:6,16 83:7 105:

10 107:4 111:14 113:15,19 115:3,

16,16 125:7 148:13 154:17 155:6

157:18 172:22 174:4 186:14,18

188:20 191:17 193:11 195:3,6

200:10 201:15,16,21 207:10 211:

11 213:13 214:9 215:12 217:16,

18 221:17,18,21 224:22 227:18

234:4 235:5,8,17,20,21,22 238:8,9

239:7 240:6 241:6,7 242:2 243:1

244:7,15 247:12 259:3,11,11,14,21 262:4,11 263:14 264:18 266:8

269:6 278:10 279:4,6,12,14,16,22

281:8 284:6,19 285:9 289:17 302:

14 303:13 304:11,20 306:11 308:

17 310:21 311:6

group=s [2] 173:3 234:11

grouping [1] 235:14

groups [46] 24:4,16 34:11 36:4 38:

8 42:17 71:17 72:5 76:12 112:20

114:10 116:16 122:21 147:5 155:

13 194:16 207:6 210:3,10 220:9,

12 222:7,9 225:4,18,22 227:10

234:16 236:10 237:19 238:13 241:

21 243:12 245:21 246:16 258:15264:20 302:1,4,19 303:20 304:1,

15 305:3 307:17 311:17

grow [1] 228:15

growing [3] 113:18 138:5 228:15

grows [1] 228:14

guaranteed [1] 225:8

guarantees [1] 103:6

guess [9] 103:1 132:5 150:4 176:

18 202:7,10 237:12 273:14 296:

17

guidance [2] 10:3 185:16

guide [1] 229:17

guidelines [1] 23:12

gun [2] 67:17,19

HHAART [7] 78:18 81:22 112:9 265:

6 266:13,13 277:16

HAI [1] 125:5half [9] 10:11 27:3,4 74:8 178:6

280:2,2,3 301:5

half-life [9] 58:12 68:4,9 82:3 160:

17 161:5,21 162:2 170:12

half-lives [2] 160:19 170:11

hallway [1] 173:16

halt [1] 211:10

HALT-C [4] 147:12,15 167:4,18

hammer [1] 97:14

hand [12] 7:12 53:12,12 207:9 214:

4 226:19 227:17 238:19 258:14

259:4 263:9,13

handle [2] 117:15 139:2

handled [1] 298:17

hands [1] 201:6

hang [1] 176:1

happen [9] 100:17 144:14 169:19

184:11 254:4 268:17 297:3 300:

10 306:19happened [2] 36:8 105:1

happening [3] 32:2 133:20 308:13

happens [4] 34:17 37:14 49:12

113:11

happy [2] 157:6,7

hard [8] 111:20 126:1 208:20 221:

4 223:14 239:8 309:21 310:3

harder [4] 209:8 249:18 259:22

294:13

harness [1] 182:22

Harvard [1] 5:20

hate [1] 283:5

Haubrich [25] 2:7 5:11,11 7:19

158:9,10 205:9,10 209:2 218:16

226:4,18,20 238:2,4 245:2,3 256:7,8 262:17,18 267:13,14 302:5,6

haveB-and [1] 92:8

haven=t [8] 37:20 106:1 173:13

234:21 240:1 271:20 275:5 283:7

Havens [54] 2:8 5:1,1 156:13,14

163:10 165:20 166:2 207:18,19

208:15,18,20 221:19,20 223:2,14

225:12,13 226:18 241:3,4 250:6,7

251:3 263:10,11 265:16,17 269:3,

4,17,22 270:4,7,14 271:2,9 284:14

288:3,4,8,15 293:21 294:4,21 295:

3,20 296:17 297:16 299:5,6 300:

19,20

HBV[5]

112:7,11 115:6 258:18282:5

HCC [1] 21:10

HCV [46] 3:16 24:11 25:10,12,13

26:8 27:1 35:5 36:17 40:18 44:19

50:14 51:9 52:7,9 55:11 58:1,4 59:

22 60:2 72:19 83:11 103:13 112:8

116:2 120:20 127:1 128:2 129:14

135:4,19 136:12 175:19 178:6

180:14 182:5 185:3,12 262:3 265:

7 268:5 276:16 282:14 286:8 300:

16 310:12

HCV-infected [2] 60:9 61:12

HCV-positive [1] 24:2

HCV-related [1] 48:22

HCV-specific [1] 185:2HCV/HIV [3] 34:13 262:2 267:5

head [3] 28:9 174:4 261:4

head-to-head [1] 132:15

headed [1] 148:13

HEALTH [13] 1:1 5:18,20 48:9 73:

4 87:4 144:4 153:15 170:20 189:8

293:15,16 298:22

health-related [1] 82:13

healthcare [5] 23:22 24:8 26:3

194:18 228:20

healthy [3] 273:20,20 293:14

Sheet 11 four-week - healthy



hear [5] 22:4 50:7 176:15 289:14

302:4

heard [12] 52:10 63:16 81:16,17

107:17 108:9 112:8 123:17 143:

20 187:14 226:5 233:20

Hearing [12] 3:27 15:19 84:3 85:6,

10 171:6,15,17 172:14,19 223:6

307:6

hearings [1] 95:22

heart [1] 213:22

heat[1]

23:16hedged [1] 121:22

held [7] 6:18 85:6 86:6 118:6 257:

1 283:22 308:17

help [10] 10:7 29:6 38:5 62:22 105:

19 140:9,10 175:20 179:5 216:4

helper [1] 56:7

helpful [4] 142:21 146:18 201:5264:17

helping [1] 10:9

hematologic [1] 290:20

hemodialysis [1] 23:19

hemodynamic [1] 205:1

hemolysis [1] 81:7

hemophilic [1] 27:10

hemotract [1] 68:7hence [10] 22:10 52:16 54:3 55:3

56:12,18 57:15 64:2 72:15 300:7

hep [13] 71:21 91:15 93:9 95:16

104:8 105:12 187:2 200:21 259:

13 271:21 307:21 310:14,18

hepatic [16] 51:1 52:9 61:10 126:

18 127:15 184:1,7,15 194:8 195:4,

10,14 196:7 219:5,7,10

Hepatitis [114] 3:8,11 6:22 9:11,14,

16 10:12,16,22 12:2,4 14:15 16:2

17:9 18:1,1,4 21:19 23:17 24:22

25:19,22 26:1 29:1 49:2 50:20 55:

7 57:14 58:8 59:7 60:21 63:9 73:1

74:13 85:17 88:21,21 89:2,2,5,6,16,17,17 91:1,3,18 93:14,17,20 95:

10,14 97:9,17,22 98:2,19 102:21

105:7 106:19 109:1,3 110:6,9,15

112:10,12,14 115:7 118:7 129:4,6

134:2 152:11 153:12 163:3 174:6,

10 180:12,15 181:6 182:12 184:2,

10 186:8,20 187:2,8 188:1 190:6

191:5 199:5 215:10 228:22 251:6

260:6 266:9 267:19 271:19 274:

16 280:10 284:9 286:1,21 287:11

290:6,12 299:8 304:21,22 306:14,

16,19 311:10

hepatocellular [17] 21:10 45:16

48:6,12 54:16 80:5 82:11 108:16

124:21 136:4 154:1 166:19 167:13 168:7,10,20 217:6

hepatocyte [10] 27:19,20 43:10,12

57:6 61:5 161:22 162:11 170:19,

21

hepatocytes [13] 28:3 30:13,17

32:7,11 52:10,13 58:12 59:8 62:8

64:1 162:2 170:14

hepatologists [1] 90:2

hepatology [6] 4:21 6:3 16:9 80:

11 174:3 290:2

here-Bof [1] 69:15

here-Bshow [1] 73:16

hesitate [1] 242:22

heterogeneity [3] 117:16 138:21

161:21

heterogeneous [4] 115:16 116:

16 138:4,18

HGV [1] 62:14

Hi [2] 4:20 190:19hidden [2] 17:11 135:19

high [32] 19:5 25:7 29:4 57:2 69:

17 70:15 73:20 76:17 77:1 78:591:18 113:10 135:4 151:6 166:7

170:2 174:16 177:16 194:4,16

210:12,20 211:1 216:15 232:15

242:6 267:6,12 289:3 298:11 307:

20 312:15

high-level [1] 186:1higher [20] 22:18 45:1,3 69:6,10,

20 72:5 146:8 177:12 194:22 235:

8 249:17 279:6 299:11,15,16 301:

8 307:10,10,11

highest [2] 75:22 200:13

highlighted [1] 88:13

highlights [1] 11:5

highly [12] 21:9 28:21 45:20 60:2

73:3 79:20 185:8 260:1 266:5 273:2 287:7 293:9

Hilton [1] 1:9

hinder [1] 206:7

Hispanic [1] 311:10

Hispanics [6] 114:7 304:9,10,17,

18 306:10

histologic [12] 15:4 47:7,12 54:8

113:9,20 125:4,18 129:15 140:2

196:5 246:10

histological [1] 54:1

histologies [1] 76:2

histology [6] 52:20 99:17 125:21

196:8 201:19 292:17

histopathology[2]

76:1 82:9historically [4] 20:21 115:4 210:

17 277:7

History [14] 3:11 15:13 16:2,20 24:

9,17,18 44:19 74:6 194:10,22 242:

21 312:11,17

hit [3] 4:7 91:7 250:16

hits [3] 91:10 92:5 98:7

HIV [102] 5:15 14:16 23:21 28:20,

22 36:18,21 46:3 72:19 73:1,4 76:

15 78:11,17 82:19 84:12,13,16 85:

18 87:16,19 88:5,17,20 90:4,22

93:3,15,16 94:2,15 95:4,4,7,11,13

97:10,17,19,22 98:11 102:14,17

103:15 105:9 112:7,8,10 115:6

125:9,11 158:19 187:2,9,11 190:6227:13 230:4,9,9 231:21 239:1

240:13,15 241:17 242:11 251:10

258:3,9,18,18 259:2,14,16 260:5,

11,18 262:8,10 263:4 265:3,11,19,

19,21 266:9,18 267:15,19 268:3,4,

18 269:8,10 277:1,16 295:7 296:3

298:10 300:15 306:3 311:8

HIV-positive [2] 187:11 265:5

HIV/HCV [1] 219:22

hoc [1] 39:16

hold [6] 96:21 159:12 220:3 221:6

243:19 283:5

holder [1] 124:4

holders [41] 12:16 14:9,21 15:4

106:18 107:1,14 108:7 111:13,19

113:6,6 115:13 116:12 118:5,21

119:5 120:14 121:6,7,20 122:3,9

123:2,5,10,11 126:2,15 130:1 135:

7 136:5,10,15 137:16 139:15 140:

8,22 154:12 194:1 198:10

holding [2] 84:3 203:21

holds[1]

71:14home [1] 97:14

homeless [1] 23:1

homes [1] 23:2

homogeneous [4] 113:13 138:2

251:1 297:17

honestly [3] 200:15 207:10 306:22

Hong [1] 129:5

Hoofnagle [2] 25:17 198:12

hope [7] 102:6 106:1 151:21 152:

17 153:4 160:1 255:8

hopeful [1] 186:4Hopefully [4] 17:12 82:8 229:5

288:1

horizon [1] 50:19

horse [1] 144:8Hospital [3] 16:9 194:20 214:12hospitalization [1] 97:18

hospitalizations [1] 98:3

hospitalized [1] 23:2

host [5] 59:13 75:11 77:4 180:22

181:14

host=s [1] 53:3

hostages [1] 312:8

Hotel [1] 1:9hours [4] 32:16 35:18 40:12 42:21

House [1] 89:4

housekeeping [1] 4:5

housing [1] 189:9

However[18]

11:11 37:21 42:1857:12 80:18 83:3 114:6 121:5 123:

4 128:9 129:8 138:16 145:18 176:

13 177:14 262:21 290:16 304:18

huge [5] 196:10 234:12,15 268:13

288:22

HUMAN [5] 1:1 96:7,9,11,17

hurt [1] 77:16

hypertension [2] 195:13 205:1

hypertensive [1] 167:8

hypotheses [5] 36:19 38:11 44:11,

12,15

hypothesis [2] 58:18 124:17

hypothetical [1] 38:10

Ii.e [2] 159:12 253:6

I=ll [1] 249:22

Ib [1] 180:11

ICAC [1] 104:17

ICC [1] 105:8

iceberg [3] 17:7,10 22:10

idea [10] 39:7 136:8 158:14 197:17,

20 198:11 210:21 230:12 266:14

282:10

ideal [3] 113:8 148:11 194:6

Ideally [4] 133:9 218:10,11 259:10

identical [2] 78:16 106:21

identifiable [2] 25:21 234:1

identification [1] 7:3

identified [4] 65:16 113:8 225:10

295:14

identify [5] 187:22 188:2 192:17

193:14 237:16

identifying [2] 246:12 281:11

II [1] 305:18IIb [1] 232:19

III [6] 22:19,22 211:15 215:22 232:

19 305:20ill [2] 214:1 231:20

illegal [2] 23:14 24:18

illustrate [1] 71:3

illustrated [3] 53:9 57:13 63:12

illustrates [1] 181:4

illustrating [1] 73:7

illustration [1] 181:18

illustrative [1] 64:21

imagine [1] 160:3

imaging-based [1] 47:11

immediate [3] 14:2 143:12 262:8

immediately [5] 35:10 68:10 160:

8 193:2 294:11

imminently [1] 200:14

immumomodulation [1] 160:6Immune [33] 3:29 29:21 52:16,18

53:11 55:9 58:13 59:1 60:6,7,12

61:6 63:7 68:7 72:12 100:19 136:

17 144:3 162:3 180:8 181:15,19,

20 182:10,14,21,22 184:6 185:1,2,

9 186:1 286:16

immune-based [4] 89:17,22 183:

6 186:7

immune-mediated [1] 57:5

immunoassays [2] 25:5,10

immunoblot [1] 25:8

immunoglobulin [1] 282:20

immunologic [6] 32:8,9 58:8 145:

16 161:16 182:15immunopathogenesis [1] 55:7

immunopathology [3] 56:11,21

60:17

immunosuppressed [1] 52:15

immunosuppression [3] 39:3

278:12 281:18

immunosuppressive [4] 56:5

277:3 278:17 281:17

Impact [24] 3:12 7:13 15:14 16:2,

20 17:9 53:22 66:13 74:15 76:20

79:1 117:19 149:12 151:18 153:8

166:20 169:18 170:21 181:10 184:

7 188:7 224:10,21 229:5

impacted [2] 170:14 173:1

impacts [3] 181:2 278:11 293:14impaired [1] 195:14

imperfect [1] 44:13

implementation [1] 262:8

implies [1] 255:6

importance [4] 18:5 102:3 261:2

281:7

important [79] 23:3 42:15 44:9 46:

3,4 49:8 52:7 55:4,19 56:20 59:4

61:19 62:10 64:6,13 65:1 67:7 72:

20 73:22 78:12 79:19 80:10 81:14,

17 84:5 87:18 90:13 92:7,22 95:2

Sheet 12 hear - important



96:15 98:15 108:11 109:4,5 122:8

134:1 138:10,15 145:4 154:22

156:11 164:1,19 165:4 167:19

170:10 172:16 184:20 193:5 195:

15 196:3,13 209:7,15 210:13 216:

13 221:16 223:15 224:22 230:16

231:19 232:18 235:5 236:13 242:

18 243:13 247:12 253:7,8 254:22

266:4 275:20 280:6 281:8 282:19

284:6 295:12 298:8

importantly[6]

52:13,18 80:2 116:4 127:22 204:21

impose [1] 281:22

impossible [2] 193:15 245:13

impression [1] 200:10

improve [6] 97:10 153:14 175:5

184:3,15 196:7

improved [3] 82:13 99:17 132:17

improvement [8] 79:19,22 82:9

99:16 125:4,6 128:20 129:15

improvements [1] 129:7

improving [1] 126:17

inadequate [3] 275:2 276:7 289:7

inadvertently [1] 283:10

inapparent [1] 47:10

incapable [1] 80:21incarcerated [3] 194:17 307:8,12

incentive [1] 93:10

incentivize [1] 271:12

incidence [3] 51:4 82:11 124:19

incident [1] 108:12

include [25] 24:16 42:7 75:16 114:

1 131:21 137:18 154:12 173:2

193:6 200:16 202:3 203:10 208:7

223:14 224:3 234:3 246:9 253:17

268:11,15 271:7 278:18 284:20

303:19 311:20

included [11] 88:8 115:21 130:7

189:10 203:12 215:19 217:10 225:

17 232:13 302:22 307:8includes [4] 88:10,11,11 263:20

including [12] 23:1 35:17 62:14

89:5 110:15 216:9 224:11 257:17

258:3 284:7 302:8 308:2

inclusion [18] 72:17 76:11 77:9,11

78:3 137:15 138:6,18 188:13,22

189:2 196:22 197:11 241:22 249:

5,6 279:13 281:14

inclusive [4] 75:17 76:6,11 203:16

incompatible [1] 224:16

incomplete [1] 72:10

incorporated [1] 134:13

incorrectly [1] 224:1

increase [8] 27:11 48:18 61:16 72:

4 211:9 231:16 248:21 303:9increased [5] 10:15 23:13 48:11

65:17 74:3

increasing [5] 60:16,18 108:17

150:16 236:4

increasingly [2] 187:10 276:2

increment [1] 71:12

IND [44] 12:16 14:9,20 15:4 106:17

107:1,13 108:7 111:13,19 113:5,6

115:13 116:12 118:5,21 119:4

120:14 121:5,7,20 122:3,9 123:1,

5,10,11 124:4 126:2,15 130:1 135:

7 136:5,10,15 137:15,16 139:15

140:7,22 154:11 194:1 198:10

260:13

Indeed [8] 56:13 58:10 73:5 135:

18 141:3 175:15 247:8 296:9

independent [4] 29:2 79:1 105:13,

14

indicate [3] 125:8 135:17 227:6

indicated [4] 108:13 117:9 234:17

268:20

indicates[2]

108:11 181:3indication [13] 11:1,4 74:13 91:12

92:3 153:22 182:13 229:1 233:7

234:14 269:15,16 271:8

indications [1] 74:12

individual [19] 19:11 20:11 24:6,19 30:16 31:10 45:9 46:8 53:7 63:

14,19 64:9 66:19 145:14 156:5

218:18,22 276:14 286:20

individual=s [1] 172:17

individualization [1] 24:14

Individually [1] 9:22

individuals [27] 45:22 67:20 69:

21 79:3 81:19 116:5 127:3 147:16

148:22 149:2,21 151:18 152:15

186:11 189:7,8,9 192:17,17 194:15 203:22 215:15 224:11 228:22

245:16 286:22 307:12

INDs [1] 12:7

induced [1] 58:5

induction [1] 281:18

industrial [1] 7:9

Industry [15] 2:10 3:23 8:12,15,16,

17 13:2 15:18 106:7,14,16 170:4

187:15 191:6 256:10

ineffective [2] 57:16 276:21

ineligible [1] 276:2

inevitable [1] 126:22

inexorably [1] 81:12

infect[1]

82:5infected [38] 11:2 21:19 22:9 23:8

27:21 28:4 30:9,11,13 32:1,7 36:

17 43:16 46:11 53:15 56:13 57:6,

8,18 58:9 63:13 64:1 73:1 81:19

82:3 108:14 112:2 161:22 162:16

170:13 181:18 182:9 184:7 187:1

199:4 228:22 272:16 287:2

Infection [59] 3:16 10:20,22 18:4

22:11,12 23:13 25:22 26:4,9,14,

15 27:5,20 28:17,20 32:4 38:3 39:

3 43:16,20 44:3,20 45:4 48:16 50:

14,20 51:9 52:8 53:14 55:8 59:7

62:11 66:9 72:2 74:4,7 78:18 80:9

83:11 99:2 108:12 109:1 180:12,

16 181:17,21 182:2,6,17 187:9,12231:10 279:11 286:13,16,19 287:

1 290:6

infections [11] 5:6 6:22 10:17 21:

7,8 22:4 51:1 58:20,21 75:21 183:

2

infectious [5] 5:2,12,14 16:14 231:

10

infectivity [1] 28:5

infects [3] 44:4 52:9,13

infer [1] 162:15

inference [1] 154:4

infiltrates [1] 68:5

inflamation [1] 75:4

inflame [1] 68:7

inflamed [2] 63:1 67:1

inflammation [7] 52:19 67:2,6 69:

10 166:18 169:2 170:17

inflammatory [5] 53:19 57:18 68:

5 170:15 196:6

inflection [1] 33:14

influence [1] 170:18

inform[4]

70:16 74:19 161:18 164:10

information [40] 8:3,6 36:4 42:7

74:17 86:21 142:21 147:13 149:

19 168:2 169:12 170:9 172:13

173:2 178:14,21 216:15 220:4,12,

14 223:16 225:21 228:4 246:19

260:12 266:4 269:19 283:19 285:

3,18 290:14 293:7,10 294:7,9,15

295:11 296:9 300:9 301:13

informative [1] 68:11

informed [3] 213:17 287:6 293:10

informing [1] 77:6

inhibit [4] 61:9 63:4 183:14 184:21

inhibition [2] 153:7 277:9

inhibitor [5] 91:15,16,20 102:15266:17

inhibitors [18] 12:8,9 85:4,13 86:5,

9 95:16,18 102:7,8,16 103:5,13,15

145:17 151:17 260:5 266:19

initial [53] 13:6 16:6 31:17 63:14

112:5 113:21 114:2 137:15 177:6

191:19 197:1,12 200:10 207:15

209:22 215:18 225:14,19 226:13

233:13 234:8 235:11 241:4,22

243:9 244:3,17,20 245:1 246:6

247:7,22 253:11 257:13 258:19

259:12,13 263:16 264:10 265:10

268:8 269:2 270:22 284:13 285:

17,19 294:9,14 296:20 297:2,3,16311:7

initially [7] 13:16 33:13 111:11,15

222:14 223:12 264:21

initiate [4] 215:14 228:6 232:20

268:9

initiated [6] 174:5 177:18 232:22

254:17 259:12 270:10

initiation [6] 179:14 228:3 243:5

262:2 301:18 305:15

injectable [2] 253:17 254:10

injected [1] 23:14

injection [1] 99:1

innate [3] 60:7,11 72:12

input [7] 10:7 118:3 121:14 129:12

133:4 185:13 197:3inquired [2] 12:18 13:20

insert [1] 294:9

insights [1] 154:10

insisted [1] 89:20

insistent [1] 131:20

insofar [1] 159:9

instance [4] 120:6 253:6 289:17

307:7

instances [3] 120:12 140:4 231:

11

Instead [3] 29:3 97:11 166:21

Institutes [1] 5:18

institutions [3] 7:10,13 194:19

instructions [1] 8:1

instructive [2] 61:8 181:15

insufficient [1] 269:16

Insurance [1] 234:12

integrate [1] 158:19

intended [1] 297:20

intent [1] 254:17

intention-to-treat [2] 249:17 275:

7interaction [16] 91:8 133:17,19

230:5 233:3 260:16 261:1,3,7,13

262:15 264:7 277:2,16 303:5,12

interactions [14] 187:21 212:13

224:18 227:20 259:6,6,18 260:4

265:1,20 268:11 277:10 303:4

312:14

interactive [1] 4:10

Interest [12] 3:5 6:12,13,15 7:15 8:

9 9:1,4,8 168:6 172:4 191:9

interested [4] 140:8 173:15 176:5

196:13

interesting [5] 169:16,19 176:15

178:8 249:8

Interestingly [1] 127:22interests [2] 7:11 8:17

interfere [2] 62:9,12

interferon [89] 11:9,13 13:22 14:

18 29:21 30:21 34:14 36:6,9 38:

17 42:1,2 51:11 58:3,6 59:11,12,

21 61:5,21 71:8 72:15 80:22 81:

15 91:22,22 100:12,16,18,20,22

101:4 112:16 115:22 116:10 117:

6 118:2,9 122:16 123:20 125:1

131:11,13 135:10 139:16,21 141:

1,3,5,6 148:5,8,8,9,10 149:1,4,10

151:7 159:9 163:8 175:6,14 176:8,

13,17 179:17 191:13 192:2 193:7,

8 196:1 231:3 247:9 254:1,4,10255:8,13,16 256:1,11,21 287:16

289:6 290:15 291:1,10 292:9

interferon-alpha [6] 59:4,9 60:5,

10,22 61:9

interferon-based [31] 21:4 29:4

37:3 63:10 72:13 109:8 113:1 114:

16 117:17 122:11,12 123:22 131:

5 134:18 135:16 139:13 141:10

150:7 156:18 158:14 159:8,15

161:2 162:19,19 179:8 183:10

192:1 195:21 196:9 221:2

interferon-containing [1] 115:21

interferon-free [1] 124:12

interferon-gamma [2] 60:15 62:

21interferon-regulated [1] 59:14

interferon-resistant [1] 193:10

interferon-ribavirin [10] 91:21

130:3 151:8 208:1 233:11,14 234:

4 235:3 287:20 290:13

interferon-treated [1] 61:12

interferon=s [2] 62:4 139:20

interferons [4] 12:9 73:15 112:13

127:12

interim [1] 167:7

intermediate [1] 262:19

Sheet 13 important - intermediate



intermittently [2] 53:21 137:9

internal [2] 18:18 98:1international [1] 247:17internet [2] 86:11,16

interpose [1] 70:17

interpretability [1] 134:15

interpretable [2] 138:3 139:3

interpretation [3] 107:21 155:14,

16

interrupt [1] 202:12

intervals[1]

193:2intervenes [1] 29:19

intervenesB-interferon [1] 29:

20

intervention [2] 38:7 55:22

interventional [1] 67:16intolerability [1] 11:19

intolerance [3] 125:1 174:21 175:

3

intranasal [1] 24:17introduce [3] 16:1,7 27:14

introduced [1] 153:10

introduces [1] 38:9

introducing [1] 206:8

introduction [6] 4:17 107:18,19

108:9 156:17 180:5introductions [1] 16:6

Introductory [3] 3:7 9:11,13

Intron-A [1] 174:5

intrude [1] 117:6

intuition [1] 136:18

inverted [1] 308:10

investigational [15] 14:11,19,2294:5,11 97:5 129:21 130:16 131:2,

15 133:6,21 179:15 214:17 247:2

investigator [1] 114:13

Investigators [1] 178:20

invited [2] 8:12 85:8

inviting [1] 83:21

involve[4]

7:9 8:20 161:20 203:1involved [14] 18:21 34:10 35:20

94:18 147:11 151:2 177:1 201:9,

10 220:20 289:16 291:20 292:8

293:3

involvement [2] 9:1,5

involves [1] 31:14

involving [2] 56:15 71:17

ionosine [1] 62:9

Ireland [1] 46:10

IRES [1] 18:19

ironed [1] 94:3

Ischak [1] 125:6

isn=t [4] 136:21 160:11 234:11

302:13

isolated [2] 19:14 20:21issue [75] 6:15 28:9 37:5 49:8 64:

10 66:17 71:4 76:22 79:9 112:12

121:15 143:12,18 144:7 145:6

150:2,7,12 156:11 161:10 162:1

164:2 167:10,13 173:9 192:9 193:

17,21,22 197:8,14 199:7,12,17

201:11 214:4,6 223:7 226:9 241:

19 244:5,10 245:21 246:12 249:9

251:13,17 258:2,11 267:8 271:19

272:9 273:14,16 274:2,5,13,14

275:14,20 276:10 284:17 298:15

299:1,2,7 301:1,22 303:4,5 308:

11 309:1,3 310:16,19

issued [1] 23:12

Issues [66] 3:9 4:5 6:21 7:2,6,7 9:

12,14 10:9,11 11:17,19 12:15,17,

21 17:13 42:18 49:11 50:9 54:6

61:20 70:8 74:18 79:11 80:17 84:

7 87:12 90:1,2 96:8 98:14 109:12

118:3 125:21 143:16 145:8 146:

12 156:11 158:12 181:5 186:1,7

188:5,7,9 189:7,8,17 190:11 193:7 195:18 202:18 212:13,21 217:1

225:10 233:3 234:21 235:1 252:4

258:9 274:1 298:4 309:1,7 311:22

itB-do [1] 254:7

itself [7] 27:21 29:1 57:14 122:6

132:12 255:15 275:12

IUs [2] 123:8,11

IUs/ml [2] 69:6 120:21

IV [3] 230:11 232:20 270:13

JJak [1] 59:12

Jan [2] 220:7,10

Janet [5] 2:5 5:19 7:19 272:15 302:

7Janice [3] 3:28 173:19 174:1

Japan [1] 168:14

Jay [1] 198:12

Jeff [1] 151:5

Joe [1] 25:17

John [16] 2:20 3:16 6:2 7:20 15:15

50:7 71:3 151:12 196:6 210:4 220:

17 273:15,21 281:13,15,21

joining [1] 180:12

journal [2] 86:18 153:20judiciously [1] 107:12

Jules [5] 3:20 15:16 83:16,17 230:

9

July [1] 23:19

jump [3] 171:8 238:2 289:2

jumping [1] 102:14

jumps [1] 17:19

jury [1] 299:19

justB-I [1] 214:14

justification [1] 154:18

KKaren [6] 2:15 3:31 4:19,20 7:19

190:17

Katherine [1] 2:23

Katie [1] 6:7

keep [11] 17:7 28:8 47:16 59:20 95:

20 102:19 126:2 170:10 193:10

199:3246:

2

keeping [1] 77:12

Ken [7] 15:12 16:1 84:6 159:20

162:6 191:2 240:2

Kenneth [4] 2:2 3:3,13 7:20

Kessler [1] 85:14

key [5] 25:15 54:5 94:4 280:15 284:

16

kibosh [1] 210:18

kid [1] 298:17

kids [6] 294:17 296:4 298:14 299:7,

20 301:15

kill [1] 197:21

killer [2] 60:7 181:20

kilo [2] 299:9,10

kind [13] 34:12 43:1 150:2 151:1

166:13 175:3 195:19 207:20 230:

20 235:22 241:5,6 277:11

kinds [5] 164:13 179:19,19 185:18

218:14

kinetic [13] 31:18 32:22 35:10,14

39:18,21 40:7 41:9 42:17 59:16

159:20 243:3 285:1

Kinetics[21]

3:12 15:14 16:3,2228:10 35:7 58:1 134:22 164:8,11

169:9 181:13 183:5 184:13 222:2

223:16 228:5 265:1,18 282:14

288:10

king [1] 120:17

Knodell [1] 125:5knot [1] 56:2

knowing [2] 54:3 78:7

knowledge [4] 83:9 137:19 158:

15 275:3

knowledgeable [1] 62:2

known [4] 77:14 170:19 178:13

245:8

knows [2] 109:8 120:8

Kong [1] 129:5

LL-aminotransferase [1] 53:17

label [2] 138:9 294:10

labeling [1] 271:7

Laboratories [2] 6:1 8:19

lack [6] 79:15 108:20 124:22 125:

20 192:7 264:6

lacking [1] 189:9

lacks [1] 19:8

ladies [1] 173:22

Laessig [3] 2:23 6:7,7

lag [2] 26:5 212:13

laid [1] 261:21

language [5] 84:21 89:5,7,8,10

languishing [2] 89:4 96:20

large [22] 27:9 46:11 66:7 67:11,12,

14 76:7 94:1 135:22 178:17 191:

17 195:21 220:16 221:21 222:9

265:5 266:8 274:18 287:21 291:

15 300:5 305:5

large-scale [1] 228:3

largely [6] 20:4 32:4 57:6 74:15

148:19 153:18

larger [6] 67:19 96:11 146:21 177:

16 225:11 259:12

largest [5] 69:19 144:13 229:1 230:

8 264:16

Larry [1] 66:7last [9] 22:16 81:10 88:14 139:16

141:9 189:2 211:5 269:5 301:20

Lastly [11] 111:2 112:18 115:8 116:

3 120:13 124:8 125:8,16 131:4

133:6 135:2

late [1] 162:15

latency [1] 108:19

later [23] 25:3 38:3 50:1 57:2 71:

13 120:3 121:9 139:17 144:12

155:6 157:7,19 163:20 164:11

187:16 208:10,18 212:9 234:22

241:18 242:1 299:5 311:21

lateral [2] 56:16,18latest [1] 86:19

Latinos [3] 75:18 98:11,16

latter [1] 51:22

laudatory [1] 276:20

Laughter [8] 146:17 198:19 238:1

272:8 295:5,10 299:21 305:8

launch [1] 272:4

launched [2] 89:1 197:17

law [1] 171:19

layers[1]

171:2lead [11] 47:20 161:5 185:10,17

186:5 224:17 233:7 270:20 288:

17 295:17 309:9

lead-in [1] 240:18

leading [12] 21:12 52:19 55:11 57:

16 81:7 86:10 97:18,22 98:3 99:2

114:11 152:14

leads [13] 19:9,16 31:1,13,22 33:

14 37:15 44:5 49:14 57:9 70:15

72:6 81:10

leap [1] 242:12

learn [5] 37:9 104:10 222:20 241:

19 256:20

learned [3] 51:10 190:5 211:8

learning [1] 109:3least [47] 16:21 21:6,7 40:8,10 54:

1 66:2 71:7 94:18 114:10 115:17

116:9 127:18,20 128:2 132:9 136:

13 145:20 206:2,6 216:12 222:5,

11 226:22 227:3,18 232:6 242:19

245:11 261:14 262:20 268:9,18

269:15 291:1,14 292:1 293:2 297:

5,20 301:18 303:19 304:13,19

307:21 308:1 310:17

leave [2] 49:19 64:14

leaving [1] 77:15

led [1] 70:2

leeway [2] 210:15,22

left[8]

30:8 31:21 44:3 54:13 56:762:20 83:8 110:5

legitimate [1] 274:9

length [2] 21:2 166:15

Leonard [4] 2:18 5:17 202:12 223:

22

less [34] 29:5 37:7 38:2 39:1 44:2

62:1 65:16 68:14 117:22 120:9,9,

20 123:16 129:3 136:3 146:7 150:

18 151:17 165:12 170:14 172:6

174:21 187:13 190:1 203:12 212:

6 214:1 219:1,2,6 244:8 286:13

298:14 310:16

lesser [4] 194:7 218:1 286:2 292:

21

lesson [1] 190:8lessons [1] 51:9

Let=s [13] 4:18 63:9 91:16 95:13

102:19 106:4,6 136:12 209:3 253:

16 254:2,4 258:17

lethal [1] 127:14level [8] 27:8 33:11,13 95:10 165:10 251:5 277:15,22

levels [14] 19:5 33:17 42:8 58:4 61:

16 127:5 140:6 165:8 260:6,7 277:

8,13 278:12,13

Levin [5] 3:20 15:16 83:16,21 230:

Sheet 14 intermittently - Levin



9

Liauw [1] 153:19

licensed [2] 178:4 207:6

licensing [1] 262:7

lie [1] 187:6

life [7] 54:22 55:3 82:13 250:4 252:

4 276:7 293:18

life-saving [1] 213:21

life-threatening [1] 261:2

lifestyles [1] 189:5

lifetime[1]

93:17light [1] 100:19

likelihood [8] 49:12 149:15,22

152:18,20 195:11 238:15 262:5

likely [32] 11:5 29:5 39:1,7 65:16

108:22 117:20,22 125:2 134:5

136:2 141:1 143:12 165:10,12

170:1 173:1 184:6 185:8 192:2

219:11 220:5 221:22 227:7 231:

20 235:8 249:21 257:19 262:9

268:17 286:15 306:20

Likewise [1] 173:5

limit [2] 63:12 292:8

limited [10] 11:18 23:4 72:2 101:

15,16,16 135:2 141:4 206:14 210:

5limiting [1] 172:5

Lindsay [4] 3:31 190:17,19 204:21

line [4] 34:19 101:7 110:12 211:15

lipids [6] 104:17,19,22 105:1,2,3

liquid [1] 291:5

Lisa [1] 74:10

list [16] 75:7 76:15 79:4 142:7 153:

13,16 199:22 205:8 210:3 216:20

217:12 228:14,14,17 276:4 312:9

listed [5] 78:21 204:2 217:1 218:1

274:3

listened [1] 264:13

listening [1] 106:2

listing[1]

210:8literally [1] 297:13

literature [9] 40:4 58:8 126:14,16

129:5,16 135:16 164:21 165:18

little [37] 22:17 28:12 35:22 38:21

47:2,3 84:11 98:9,20 100:4 101:2

131:14,14 156:10 158:18 163:11

169:3 178:14 207:20 208:2 210:

15,22 211:17 216:4 218:8 219:12

242:11 243:6 245:4 262:18 277:

21 294:7,8 300:18 301:21 307:9,

11

liver [93] 5:17 6:3 11:1 13:13 17:16,

21 18:2,12 21:12 22:6 23:20 25:

20 26:11,12 28:1 45:10,13,15 46:

22 47:4,5,18,20 48:3 54:5 55:1561:17 62:20 66:17 68:7,8 71:15

73:8 75:2 101:14 105:3 108:16

109:4 110:9,13,19 111:22 113:22

119:19 120:2 124:20 126:3,6 127:

4,6,10,14 128:16,19,20 134:16

136:3 137:17 143:11 144:5 152:9,

16,19 160:20 187:9 195:5,5,13

199:16 203:2 212:6 213:15 215:8

219:20 221:11 222:20 223:8,9

228:4,6 230:7 231:14 232:1 273:6,

20 276:7 284:18 285:10 286:14

293:5,13 296:3 298:20

liver-related [1] 48:13

livers [1] 61:11

lives [2] 261:7,11

living [5] 84:14 145:3 152:8 260:

18 293:16

load [30] 27:1,2,11 28:21 29:1 30:5,

10 31:18 33:5,10,20 37:6 41:19

43:14 63:13 69:4,18 113:10 127:4

135:22 140:11 162:11 163:16 165:

14 166:22 169:21 183:10,22 184:13 267:12

loads [6] 28:13,15 29:5 69:6 267:6

282:13

lobule [1] 47:4

localized [1] 60:15

lodging [1] 173:4

log [7] 27:3,5 37:8 116:2 129:14

236:3 238:19

logical [1] 212:3

long [25] 12:22 33:18 37:19 41:12

63:21 64:11 68:9 77:21 80:3 96:

20 103:17 106:1 108:19 142:7,10

144:21 163:1,12 214:20 228:12

239:3 246:22 264:3 288:4 293:15

long-term [23] 7:4 24:10 49:16 61:20 80:6,7 82:12 104:7,9 105:6

135:14 137:1,7 141:19 149:8,12

162:14 163:3 167:10 169:4 175:

16 184:5 244:7

longer [16] 20:12 28:6 45:8 68:15

73:17 82:4 119:2,10,16 133:15

136:19 141:15 157:16 192:20 217:

13 249:22

look [54] 17:15 27:4 33:2 36:4,8,16

39:22 46:21 50:18 51:10,16 54:19

59:16 64:6,20 66:17 69:5 73:13

74:10 79:5,11 90:3 93:15,19,22

111:21 143:22 145:7,20 148:18

149:18 157:19 168:2 174:20 181:15 182:13 233:1,2,17 236:20,20

240:11 241:10 243:3 260:3 277:

20 280:3 304:2 305:18 307:22

309:7 311:8 312:9,13

looked [4] 27:1 149:2 254:19 286:

10

looking [30] 22:21 33:16 39:17 45:

21 46:10 49:11 59:5 79:2 102:5

113:3 115:17 137:8 143:7 146:3

151:15 152:6,21 168:8 171:3 184:

8 193:6 205:18 211:16 213:5 238:

4,12 246:18 264:22 273:3 275:16

looks [8] 53:18 57:22 61:20 73:6

91:17 227:18 271:17 280:1

Los [1] 86:7lose [1] 175:22

losing [1] 199:3

loss [5] 25:7 30:16 42:8 175:15

237:13

lot [31] 29:11 39:15 84:7 90:19 93:

11,12 94:9 95:11 98:17 104:10

131:19 178:1 192:20 196:7 213:

20 218:9 226:9 227:14 238:5 240:

14,22 263:11 266:18 267:16 278:

14 289:22 298:12 309:14,15 310:

2,3

lots [1] 104:11

loved [1] 121:2

low [18] 23:7 24:7,12 69:5 135:5

149:22 150:15 204:12 238:9,18

271:22 275:8 278:22 280:4 282:

11,12,13 309:4

lower [21] 14:17 33:13 63:12 72:7

104:18 112:22 123:9 131:11,14

146:8 169:20 194:16 195:11 255:

6 266:3 275:16 300:17,18 301:11

302:20 303:6lowering [1] 300:13

lowest [1] 111:17

LSU [1] 5:7

lucky [1] 280:10

lunch [3] 142:6 171:10,12

lymphocyte [1] 55:12

lymphocytes [3] 18:13 52:10 55:

20

MM.D [21] 2:2,6,7,8,10,12,15,16,18,

20,22,23,24 3:3,9,13,16,24,28,29,

31

made [22] 6:16 24:20 48:10 53:4

90:20 95:11,12 98:2 102:14 155:7,13 156:2 157:15 184:20 192:16

214:19 218:7 224:1 239:19 268:9

288:15 292:20

magnitude [1] 182:4

main [7] 25:1 29:3 39:9 90:18,21

108:2 302:22

mainly [1] 194:12

maintain [2] 260:5 282:16

maintains [1] 260:7

maintenance [2] 167:4 281:18

major [16] 67:10 75:1 76:12 87:3,4

88:19 119:1 135:4 241:7,9 245:11

268:11 303:19,22 307:16 309:3

majority [5] 107:6 194:9 298:19

304:16 311:10

make?@ [1] 37:8

makeB-because [1] 90:19

malignant [1] 51:5

managed [1] 168:3

management [3] 23:22 163:6 203:

19

mandate [2] 243:16 293:2

mandated [2] 273:5 284:12

mandating [1] 299:1

manifest [1] 45:13

manifestations [2] 51:2 80:1

manipulating [1] 131:13

manner [4] 18:3 81:6 205:21 282:

4manufacturers [2] 85:8 254:3

many [47] 7:9,13 20:1 22:12 44:9,

14 46:1 61:13 67:15 73:7 75:15

76:13 77:3,10,13 88:16 89:16,16

90:2,2 99:1 105:5 111:8 143:14

150:19,21 152:10 172:8 179:1

189:5 197:4 210:2 215:7 219:13

234:1 242:19 247:2 251:2 261:5

274:22 276:3 289:19 295:2,7,7

299:15 306:2

March [3] 86:4 106:17 126:5

marches [2] 120:8 135:18

marginalized [2] 98:22 99:1

mark [1] 40:16

marker [2] 29:2 53:19

markers [2] 61:15 181:14

market [18] 11:10 90:13,15 91:7,

10 92:5 93:6 94:17 98:7 100:2

103:6 105:19 155:3 199:20 200:8

207:3 242:7 299:4

marketB-I [1] 207:2marketing [8] 13:8,14 215:18,19,

22 248:15 264:10 285:17marrow [2] 127:13 150:12

marvelous [1] 231:6

Maryland [2] 1:10,11

mass [1] 161:22

Massachusetts [1] 16:9

master [2] 19:15 25:15

matched [2] 35:5 36:9

maternal [1] 112:3math [3] 29:11 31:1 286:5

mathematical [4] 19:21 29:9 31:

14 41:17

mathematics [1] 35:19

matter [4] 151:10 161:3 186:2 252:

6

matters [1] 7:17maximum [2] 172:5 299:17

maxing [1] 217:2

McHutchinson [1] 71:4

mean [32] 33:3 91:13 104:4,5 112:

7 117:13 128:8 165:17 177:17

200:21 213:19 221:11 223:7 231:

13 236:17 245:17 247:11,13 251:

19 282:12 283:15,20 294:10 297:

14 298:13 303:17 304:2,11 308:8

309:16,18 312:7

meaning [5] 30:13 44:3 197:8 227:

11 302:10

meaningful [4] 140:6,10 163:21

238:21means [8] 77:7 122:13 155:10 211:

18 214:16 227:13 307:9 308:14

meant [1] 17:2

measure [4] 53:18 79:20 164:3,7

measured [2] 121:16 156:21

measurement [3] 25:13 35:18

121:18

measurements [1] 183:11

measuring [3] 27:2 147:3 253:15

mechanism [5] 32:6 132:6 181:11

183:13 185:9

mechanisms [11] 27:17 32:9 51:

11 57:22 59:3,19 62:3 72:10 133:

10,22 192:8

median [1] 26:6mediated [3] 52:16,22 60:18

Medical [17] 3:19,24 5:2,7,15 6:5

10:2 16:15 24:8 49:5 86:21 179:

22 180:7 198:4 217:17 219:4 300:

8

medication [1] 292:13

medications [3] 290:18 291:1

312:14

Medicine [5] 3:17 5:15 6:3 98:1

192:12

medicines [2] 189:20,22

Sheet 15 Levin - medicines



meet [5] 103:8 111:4 175:13 215:7

291:22

meeting [18] 4:3,12 6:17,18 7:9,21

8:3,14 12:13,15 15:11,12 17:12

50:5 172:15 173:1,5 312:3

meets [1] 6:20

MEL [1] 151:12

MELD [15] 79:20 128:17 129:8 140:

7,11 145:21 146:7,8 204:9,11 225:

6 278:22 279:2,6 280:4

member[3]

7:15 62:15 186:18MEMBERS [10] 2:4 4:6,18 7:10 9:

17 16:5 114:8 142:11 197:4 288:2

membership [1] 105:16

men [4] 38:18 188:14 201:14 308:

20

mental [2] 189:8 293:16mention [8] 84:8 88:14 95:15 100:

4 101:12 188:10 293:18 312:10

mentioned [21] 21:6,11 72:19 88:

1 98:17 99:12 100:6 103:2 115:5

135:11 145:6,19 160:11 174:11

178:10 181:22 191:2 195:19 210:

4 280:18 312:12

messes [1] 35:19

met [2] 87:3 150:17metabolic [2] 51:4 188:11

metabolics [1] 104:12

metabolism [6] 133:18 219:5,10

233:1,4 277:10

metabolized [2] 170:19 227:15

metallo-matrix [1] 61:18

methadone [1] 99:4

method [1] 29:20

methods [1] 25:11

Mexican [2] 304:11,19

mg [3] 255:22 301:3,5

mid [1] 174:7

middle [7] 59:10 158:21 212:16

304:3,3 309:10,22might [62] 20:10 37:7 58:16 85:22

100:16 101:1 103:8 107:3,8 114:

22 119:11,17,21 128:14 130:13

132:16 133:17,19 134:17,19,19

142:21 143:5 144:14 153:6,22

154:4 162:6 163:17 166:19 169:

18 178:12 181:2 185:14 192:21

204:11 206:10 208:2,5 209:5 212:

17 214:13 221:11 222:7 229:13,

15,17 238:7,20 241:5 242:15 243:

6 249:13 266:16 267:10 269:12

279:17 284:9,11 290:10,10 295:

17

Mike [1] 40:15

mikes [1] 4:7milder [1] 112:3

mildly [1] 127:19

miles@ [1] 83:8

milieu [3] 56:3 63:5 170:15

military [1] 23:1

million [10] 10:19 11:2 21:7,8 22:8,

13 23:8,8 108:10,10

Milwaukee [1] 5:3

mind [20] 17:8 47:17 59:20 74:17

82:15 94:10 95:20 102:20 143:16

170:10 182:22 206:4,18 214:6

223:22 224:20 232:1 246:2 290:8

309:13

minds [1] 136:14

mine [1] 116:17

minimal [5] 147:21 166:14,15 231:

18 290:20

minimally [1] 151:11

minimize [4] 46:15 134:20 276:18,

20

minimizing [1] 298:20

minimum[4]

168:15,16 177:7 261:12

minor [2] 33:7 34:4

Minorities [1] 137:18

minority [1] 201:3

minus [2] 29:14 31:6

minutes [5] 92:18 172:1,5 186:12

203:8

Miriam [9] 2:14 16:13 49:21 146:

13 147:10 216:19 223:7 306:8,14

mirrored [1] 48:18

Miss [2] 259:5 290:18

missing [2] 43:3 290:19

mistake [3] 102:13 126:4 223:3

mistakes [4] 95:11,13,14 102:4

misunderstand [1] 294:3misunderstanding [1] 157:3

misunderstood [1] 205:6

mitigated [1] 8:11

mix [1] 281:19

mixed [3] 185:15,18 304:10

mobilizing [1] 185:1

modality [2] 185:15,18

model [18] 34:20 35:2,13,16 36:142:11 43:4 49:14 90:4,22 94:12

95:3 125:11 128:16 165:2,6 242:

11 290:3

Modeling [17] 19:5 29:6 31:14 32:

22 36:3 37:9 38:6 39:21 41:9,16,

17 42:4,17 81:21 161:18 166:1170:8

models [21] 34:17 35:20 39:19 42:

7,12 43:6 44:1,8,13 59:8 60:17

160:22 164:14,18,20,22 166:5

184:8,10 275:10 290:13

modifiable [2] 43:18 46:8

modification [1] 278:16

modified [1] 255:19

modifier [3] 46:3,4,5

modifiers [1] 46:2

modulators [1] 29:21

molecule [4] 29:22 221:3 241:13

242:3

molecules [4] 12:8 160:18 240:3

247:9moment [4] 112:19 147:1 191:7

271:16

momentB-and [1] 221:10

moments [1] 112:8

money [1] 214:7

moninfection [1] 88:3

monitor [2] 179:10 278:13

monitored [1] 141:21

monitoring [3] 211:9 277:8 308:

14

mono-infected [3] 35:5 91:19

272:20

mono-infection [15] 87:14,16,21,

22 88:10 91:13 99:21,22 100:7

187:19 261:22 262:4,13 271:15

310:12

mono-specific [1] 60:3

monophosphate [2] 62:8,10

monotherapy [28] 14:14 15:1 58:

3 61:13 64:10 80:22 103:11,16

118:19 119:12,16 130:9,13 132:

21 135:3,10 140:17 141:4,7 148:8,9 163:12,15 190:3 209:6 236:2

240:21 282:21

monotherapyB-agreement [1]

135:2

month [2] 71:14 166:10

months [6] 26:15 37:11 110:10

119:3 175:18 252:20

moot [1] 231:12

more.@ [1] 136:7

morning [22] 9:15 10:10 29:11

106:9,10 111:9 142:3,12 174:9,12

175:7 177:14 178:2,7 190:4,20

191:16 193:22 198:9 233:21 237:

22 312:22

mortality [7] 48:13,17,18,22 74:379:21 151:6

most [59] 10:22 20:18,20 21:18 22:

19 27:1 30:19 31:21 43:15 47:9

64:22 70:14 71:21 75:20 76:19 77:

19 78:12 90:9 98:21 99:5 109:3

113:13 118:8 120:19 125:2 134:5

138:2,3 143:12,13 146:12 154:16

166:11 175:10 189:13 192:11 204:

21 205:17,17,20 207:4 210:1 211:

22 216:10 219:13 222:7 232:17

235:21 272:1,3 283:7 286:15 292:

10,21 293:4 297:17 298:15 304:

22 306:19

mostly[2]

126:13 310:12mother [2] 109:2 287:2

mothers [1] 24:2

motivated [2] 287:7 293:9

move [19] 17:13 50:10 90:1 96:2,3,

10 99:7 100:14 101:18 105:15

108:4 122:12 163:21 176:20 200:

9 209:4 264:8 266:11 305:20

moved [1] 80:15

moving [12] 21:17 81:11 110:12

118:5 122:19 126:1 131:10 137:

14 146:7 176:21 199:15 229:2

mRNA [1] 61:10

MS [11] 5:4 197:16 211:13 212:2

234:10 240:10 260:15 266:7 271:

11 305:17 312:7much [58] 10:3,7 15:22 17:10 31:

15 32:12 36:11 37:8 38:3 41:19

45:3 50:15 58:7 67:18 83:14 86:

15 88:18 103:20 105:22 118:16

126:3,14 127:9 142:4 160:12 177:

1 180:1 194:21,21 198:2 201:9

202:5 209:6 235:8 237:11 242:12

252:2,4 258:9 264:7 271:3,20 275:

19 277:19 279:2 281:1 285:18

289:13 290:16,22 298:18 299:15

301:5,8 304:13 311:15,17 312:21

multi-drug [1] 134:7

multi-investigational [2] 96:13

105:18

multi-phase [1] 164:18

multi-specificity [1] 59:21

multiple [16] 18:11 19:12 24:10,22

34:15 94:5,11 97:4 100:14 121:13

179:15 214:21 246:20 257:15 275:

17 276:15

multispecific [1] 55:14

Munk[5]

2:9 16:11,11 229:21 268:2

Murray [18] 2:15 4:19,20,20 7:19

154:8 272:6 285:12,15 289:12

291:14,20 292:7,16,19 294:18

295:1 299:18

must [6] 58:22 188:8,16,18,19 209:

21

mutagenic [1] 62:15

mutation [1] 235:1

mutational [2] 179:20 235:7mutations [1] 170:1

mutually [3] 56:6,9,14

mycophenolic [1] 277:20

myself [4] 52:2 84:12 126:2 286:6

mysterious [1] 117:12

Nnaive [36] 13:7 14:4 56:1 118:6

139:7,8 140:16 143:8 201:21 202:

1 206:9 210:18 211:9,10 217:21

233:11,13,22 234:7 235:9 237:5

238:5 240:7 244:2 246:17 259:13,

16 262:2,3 263:15 264:5 272:12

275:11 280:19 283:6 285:9

naive-treated [1] 143:1

naivete [1] 283:4

name [4] 173:13 174:1 180:6 186:

16

Namely [2] 12:18 149:3

narrow [4] 182:11 247:4 296:21

297:1

NATAP [6] 3:22 83:18 84:13 86:5,

10,12

National [4] 3:22 5:18 74:10 83:18Natural [13] 3:11 15:13 16:2,19 44:19 58:11 60:6 74:6 82:3 194:10,

22 204:5 242:21

naturally [1] 181:16

nature [9] 8:10 22:18 87:19,20 99:

19 154:15 257:11 274:15,16

NDA [1] 180:15

near [4] 163:5 176:7 218:4 225:9

near-term [1] 185:10

nearly [1] 72:7neat [1] 234:1

necessarily [17] 58:13 59:22 92:3

105:13,14 206:12 211:10 233:6

236:17 256:18 257:14 260:9 284:

12 291:9 293:8 300:21 303:9

necessary [6] 62:11 141:11 165:

14 230:2 304:12 311:21

necessity [2] 41:14 260:8

necroinflammatory [1] 203:16

need [137] 4:7 11:3 13:14 23:22 24:

5 44:12 47:16 50:10 67:14 68:2

72:15 81:15 88:6 90:3,16,22 91:2

Sheet 16 meet - need



93:10 95:20,22 96:2,6,9,18 98:5

99:6,8 100:1,18,21 101:2,17 102:

8,20 104:7,8,9 105:5,12 111:10

113:17,21 114:12 122:13 124:4

126:19 133:12 136:7 138:6,9 141:

15 142:13 146:9 156:12 157:18

166:3,4 174:19 176:19 177:7 179:

10,16,22 184:2,13 187:21 188:6

190:7 192:3 197:3 198:2 199:18

200:3,15 201:8,14 202:3,7 203:3,

11 210:1,21 212:11 214:18 215:7,19,20 217:5 220:4,9,11,16 229:11

230:14 234:3 237:19 238:22 239:

13 242:3 243:1,10,16 246:19 247:

13 248:10 249:22 258:12 260:2,

18 261:11 266:10 267:2 268:22

280:8 284:1 285:5,7 289:1 294:15

295:15 296:12,19,21 299:11,16

301:3,5,8 303:9,14 305:18 309:19,

20 310:4 312:1,13,18

needed [5] 109:18 206:16 232:10

256:21 263:3

needing [1] 291:5

needles [2] 67:14,17

needless [1] 138:14

needs [16] 54:20 69:22 80:7 94:296:4,16 120:7 139:12 195:15 199:

17 201:17 225:17 232:16 246:18

308:16 309:1

negative [13] 26:10 35:11,11,11

40:15,18 70:14 123:18 147:2 175:

19 181:10 243:4 265:11

negativity [2] 70:9,11

neighboring [1] 82:5

neighbors [1] 20:5

net [2] 210:7 274:5

never [3] 95:8 240:7 276:4

New [77] 5:5,16 10:17 11:4 22:4 31:

6 32:4 43:10 50:4 51:14,17,19,20

55:22 57:17 64:22 72:16 75:8 77:8,13,15 80:12 81:13 82:16,20 83:

9 86:1,6 87:9 89:16,20 94:14 95:3

98:4 102:4 103:3,7 109:17 117:7

118:16 133:2 138:16 143:8 153:

20 158:11 160:20 169:9 174:18

175:8,12 176:9 177:3 179:6 187:3

189:22 191:14 194:4 206:21 210:

12,14 217:19 218:19 221:3 242:2

247:9 250:11,16 256:12,15,22

266:15 276:16 290:3 291:3 303:7,

12 304:2

newer [4] 117:9 140:2 157:4 285:

20

newest [1] 54:17

news [6] 86:19 89:15 90:6 108:12,14 109:18

next [24] 10:10 37:12 48:22 50:7,

18 83:16 95:9 149:17 158:1 168:1

180:3 190:16 191:10 203:8,14

216:6 233:10 238:3 244:19 256:

17 258:2 274:19 285:11 287:22

NHANES [2] 22:19,22

NIAID [1] 198:13

nice [2] 58:15 304:18

nice.@ [1] 125:14

nicely [1] 84:6

NIDDK [5] 5:18 71:21 147:11 152:

7 198:13

NIH [7] 105:14 191:6 198:10,16,16

202:1 220:19

NIH/Roche [3] 291:17,21 292:7

Nile [1] 20:19

nine [2] 20:1 291:7

NK [1] 60:14

Nobody [1] 125:13

nodding [1] 272:6

nodular[1]

66:22non-A/non-B [1] 191:5

non-alcoholic [1] 46:12

non-C [1] 74:12

non-fibrotic [1] 69:9

non-Hispanic [7] 21:21 71:20 72:

6 304:6,7,14,14

non-immunosuppressed [1] 46:

12

non-inferior [2] 132:17 253:18

non-inferiority [12] 79:10 248:18

249:9,12 251:14 252:6,13,16,19

256:13 257:2,18

non-injecting [1] 24:18

non-interferon-based [3] 122:14

124:2 136:9non-invasive [3] 101:15,19,21

non-nucleosides [1] 260:4

non-pegylated-interferon [1]

254:21

non-placebo [1] 150:3

non-responder [15] 115:18,19

116:15 117:21,22 124:22 134:14

138:14 143:19 178:18 235:3,17

236:18 237:4 239:12

non-responders [34] 65:5 75:10

76:5 113:18 115:14,15 116:6,19

125:17 134:7 139:2 140:21 141:3

148:2 149:8 166:15 168:18 178:9,

11,14 179:7 190:11 193:12 194:2200:11,12 201:18 235:20 236:20

237:8 239:20 240:15 243:2 287:

17

non-response [8] 40:1 42:19 64:

20 66:2 68:22 69:20,22 70:3

non-responses [1] 307:21

non-responsive [3] 70:2,5 308:9

non-structural [2] 55:10 61:2Non-Voting [3] 2:10,19 8:15

none [3] 122:3 128:1 167:6

noon [1] 171:11

normal [7] 26:11,15 32:10 47:1110:21 111:1 162:2

normalization [1] 125:7

North [2] 66:9,14Northwest [1] 286:7

note [2] 23:3 56:20

noted [3] 9:2 125:17 187:7

notice [4] 16:4 107:10 116:16 182:

3

notorious [1] 266:21

notoriously [1] 281:20

novel [25] 117:7 119:12,16 124:8,11 130:19 131:22 132:13,20 133:

12,21,22 134:9 138:16 140:20,22

141:13 152:22 159:18 160:13 180:

21 181:10 239:6 255:14 282:3

nucleocide [1] 151:16

nucleocide/nucleotide [1] 153:

11

nucleotide [1] 18:17

null [6] 116:20 238:13 239:6,20240:16 307:20

number [37] 14:8 17:17,19 25:17

26:20 39:10 41:20 49:14 66:7 67:

12 69:1 76:7 102:7,8 125:13 130:

22 142:15 152:3 168:8 172:6 174:8 186:21 188:4,5 189:11 190:3

212:18 217:2 220:16 245:16,20

258:9 268:13 286:13 290:11,11

302:11

Numbers [6] 19:7 35:12 41:21 48:

13 263:19 296:22

numerous [1] 274:22

nursing [1] 23:2

NUY [1] 84:16

Oo=clock [3] 15:19 171:4,5

o=clockB-is [1] 301:22

obesity [1] 46:5

objectives [1] 7:1obligated [1] 14:22

obligation [1] 215:14

observe [1] 182:8

observed [3] 19:10 32:20 183:9

obstacle [2] 291:10,11

obtained [1] 8:5

obviate [1] 254:10

obviously [28] 69:17 78:12 82:12,

18 93:16 96:8 110:8 115:15 118:2

123:4 128:9 134:16 152:10,22

156:11 178:4 191:22 192:14,22

199:21 211:6 213:16 228:8 236:9

238:7 279:15 280:7 291:6

occasion [1] 155:21

occasional [1] 163:9occult [1] 126:8

occur [11] 10:18 22:7 27:12 42:9

43:13 65:9 112:5 160:4 170:1 187:

17 222:6

occurred [1] 102:16

occurring [2] 32:5,13

occurs [4] 72:4 160:14,20 161:3

October [2] 1:7 313:2

off-label [2] 289:9 298:16

off-treatment [2] 131:7 268:3

offer [4] 163:4 213:15 241:2 311:

12

offered [12] 83:5 124:5 125:4,13

129:9,10,15 130:21 138:19 140:7217:13 279:4

Office [1] 8:6

Officer [4] 3:25 5:10 6:5 180:7

offices [2] 87:5 126:6

often [16] 25:5,20,22 32:7 38:12,22

41:13 86:17 114:11 150:21 153:

14,15 161:2 221:5 282:13,15

okay [9] 131:18,19 203:6 226:8

244:18 257:21 269:2,22 284:13

old [7] 82:16 190:8 299:9,10,11

300:2,2

older [1] 21:20

olds [2] 298:1,2

oligonucleotides [1] 12:11

OLT [1] 80:9

on-Band [1] 176:14

onB-is [1] 176:16

once [14] 27:5 48:1,6 53:4 54:19

55:1 83:3 91:9 121:8 169:16 187:

11 206:21 212:9 230:10

one [146] 8:18 11:6 13:11 15:19 17:

22 18:10 20:11 27:15 29:19,20 32:

17 37:21,22 39:9 40:14 43:20 45:9,14 53:15 56:6 61:19 64:11 65:

20 66:12 69:17,22 70:12 73:5,7,8

74:11 76:11 77:4,5,21 78:15 79:1,

5 80:11 88:19 89:22 94:19 95:3

96:8 101:20 103:4 107:6 113:7

115:20 117:14 118:17 119:19 122:

8,15 123:9 124:4 125:4 127:17

129:13,14,19 130:5,21 135:8 144:

7,13,19 147:20 155:10,11 158:4,

12,17 159:18 160:2,3,16 171:5

174:20 175:20 176:22 177:2 178:

11 179:18 182:14,15 186:22 188:

17 189:2 192:11 194:19 198:9

200:18 202:13,17 205:12,14 206:

15,20 212:20 213:1 218:7,16 221:20 222:16 224:6 226:17 229:9

231:6 234:1,21 239:21 240:20

252:20,21 253:1 256:4 262:1 263:

7 264:14 265:4 267:4,7 270:15

272:1 275:20 279:4,14 280:1 281:

10 282:2 290:8,11 291:4,21 298:9

299:7 302:2 303:13,14,18 305:11

306:17 308:6,17,22

one-by-one [1] 229:22

one-stop [1] 206:19

one-way [1] 158:20

ones [4] 43:15 239:4 273:9 295:13

ongoing [17] 57:18 90:4 110:9

147:12 149:7 162:3 177:18 180:10 183:2 215:21 216:3,13,18 217:

21 224:20 233:8 264:14

ongoing-Blet=s [1] 136:11

only [34] 43:20 46:14 56:14 65:20

66:6 68:10 114:3 117:5 122:10

139:12 140:5 145:21 149:10 153:

4 157:18 159:14 161:19 165:16

187:3 206:22 219:19 225:5,6,7

249:10 254:13 255:9 257:13 265:

11 272:18 279:7 293:15 294:21

306:9

OPEN [9] 1:5 3:27 15:19 171:6,15,

17 172:14,19 308:17

Opening [2] 3:2 4:2

opinion [11] 107:7 121:7 175:21176:15 198:8 205:13 208:7,15,21

280:16 303:18

opinions [4] 107:9 115:13 122:4

211:21

opportunities [1] 51:21

opportunity [10] 80:14 108:15

138:16 142:11,17 171:7,17,20

180:1 276:5

opposed [6] 111:19 154:13 184:

22 238:9 302:15 303:6

opt [2] 137:3 249:20

Sheet 17 need - opt



opted [1] 141:20

optimal [2] 68:2 290:4optimist [1] 83:11

optimistic [2] 133:15 136:5

optimistically [1] 280:1

option [4] 129:20 140:5 179:12

217:17

options [5] 102:19 113:2 129:18

140:14 268:4

oral [12] 94:19 97:7 100:15 101:3,6

104:4 130:16,17 172:20 176:17291:6 292:14

Order [11] 3:2 4:2,4 68:8 142:19

161:10 192:9 200:7 229:18 296:

13 309:21

organ [6] 204:10 217:13 225:8 276:

9 279:4 280:8

organization [2] 84:15 86:5

organizations [2] 87:6 88:18

organs [2] 23:18 276:10

orient [2] 51:7 74:19

original [5] 152:2 215:18 224:21229:3 232:13

orphan [1] 215:4

other [115] 8:21 9:3 11:16 17:11

18:14 19:22 20:5 24:4,17 29:2130:4 34:16 35:5,16 46:13 52:2,12

55:15 59:8 60:10 78:5 80:21 86:

10,15 94:4 98:14 99:18 103:4 104:

13 107:5,8 113:16 114:1 115:2

117:2 118:10,15 122:4 128:9 130:

7 131:12 132:1 135:20 149:1 151:

15 157:14 158:15 160:10 163:10

164:15 165:3,7,13 173:4 182:20

184:5 193:13 196:5 204:11 207:9

210:3,10 213:12 214:4,6,7 215:17

219:21 220:9,19 222:10 232:5

233:3 237:15 238:19 239:4,6 243:

22 244:1,22 245:17 247:19 249:7

252:16 257:16 259:4 260:17,22266:13,15,18 268:1,6 272:2 277:2,

12 278:19 279:15 282:2 283:2,18

284:20 286:11 287:2,10 288:2

290:8,9 291:4 292:3 295:21 302:

14 305:4 307:21 312:1

other=s [1] 56:15

others [15] 12:11 78:13 92:4 136:7

146:3 151:6 195:19 206:8 213:5

221:15 239:16 274:10 286:10 293:

1 310:1

otherwise [4] 95:17 103:14 141:6

255:12

ought [3] 159:11 262:20 307:22

ourselves [2] 221:15 294:15

out [63] 23:17 27:4,8 30:7 32:6 33:9 58:9 66:18 77:7 84:12 94:3 96:

14 97:3 102:16,19 105:17 136:1,3

137:8 144:20 147:5 158:11 162:7

164:22 172:9 183:8,21 191:16

196:6 199:19 200:8,15 204:22

217:2 220:15 222:7 227:4 230:10

239:4 243:11 257:21 263:8 268:

13 269:13 270:7,17 272:10,14,20

281:14 283:10,15 284:2 285:8

289:8 293:8 296:15 299:4,20 300:

20 308:15 310:5,6

outcome [12] 39:4 42:11 53:16 54:

1,9,21 116:14 149:13 168:6 224:9

253:2 279:19

outcomes [3] 43:2 44:17 233:6

outliers [1] 42:15

outline [1] 107:17

outlined [1] 68:22

outside [7] 8:2 67:22 172:3 180:9

198:12 294:22 295:2

outstanding [2] 190:21,22

over[33]

10:3 19:14 27:11,12 29:13 36:12 37:11 46:1 48:22 50:19

74:5 86:13 87:1,2,11 100:15 107:

20 110:12 112:7 117:10 129:19

133:13 150:16 170:15 175:22 248:

21 254:18 263:7 286:2,10,15,15

289:3

over-call [1] 160:12over-representation [1] 21:20

overall [7] 25:14 71:5 148:14 230:15 249:16 271:21 310:10

overcome [1] 200:19

overlap [1] 210:2

overlaps [1] 273:7

overly [1] 240:10

overnight [1] 86:17overview [2] 16:19 285:13

overwhelmed [1] 92:15

overwhelming [1] 298:19

owing [1] 73:2

own [6] 198:17 201:22 242:4 248:7

271:8 285:16

Pp.m [3] 1:8 171:13 313:1

P450 [3] 259:6 261:20 268:16

Pacific [1] 286:7

package [2] 271:15 294:9

page [4] 8:1,2 17:3 142:22

paid [3] 92:19 234:15 289:10

paired [2] 239:3,5

panels [1] 95:7

paper [2] 26:19 41:2

paradigm [6] 14:16 39:10 95:4

162:17 240:16 280:12

paradigms [2] 37:13 82:16

parallel [4] 37:1 261:22 262:12

263:3

parameter [4] 31:2,6 37:22 43:9

parameters [4] 40:1 41:5 43:7

266:13

paraphrased [2] 49:20 222:15

paraphrasing [1] 302:18

parenchyma [1] 67:22

parenteral [2] 118:8,20parenthetically [1] 49:20

Parklawn [1] 8:7

parroting [1] 302:7

part [32] 6:16 30:7 38:15 52:20 96:

12 107:10 108:3 112:5 113:1 138:

12 145:18 152:12 163:18 191:13

192:15 193:8 223:11 224:4 229:

18 232:2 235:9 237:5 244:3,17

256:21 262:15 269:5 281:3 287:8

289:18 292:21 294:19

partial [5] 116:20 192:5 193:4 235:

18 236:21

partially [2] 30:21 68:11

PARTICIPANTS [7] 2:1 8:22 9:1,

3,21 194:12 241:18

participate [1] 137:18

participating [2] 7:21 8:14

participation [1] 137:20

particular [22] 7:7 8:18 19:22 22:

11 30:16 31:9 33:22 72:16 74:22

79:7,8 93:3 121:15 159:5 168:6

205:12 206:6 219:8 242:16 258:

17 261:16 312:14particularly [22] 19:13 25:4 27:9

35:19 45:2 60:6 67:15 79:19 91:4

146:20 158:13 178:3 188:21 190:

4 220:20 238:13 246:8 248:2 267:

20 268:12 275:18 285:13

partly [2] 208:20 274:4

partners [2] 24:10,11

parts [4] 17:10,11 245:17 247:19

passes [2] 89:6,11

past [5] 87:1,8 114:9 148:7 186:19

pathogenesis [3] 51:10 52:7 303:

10

Patient [62] 2:17 12:19 13:5 14:3,

12 15:7 19:11 20:11 25:18 33:22

34:13 35:1,6,6,8,13,21 41:13 42:13,21 44:21 51:19 64:21 70:21 74:

4 78:14 87:3,12 90:9,15 115:3

116:1 121:8 126:22 127:13 134:2,

4 137:7 144:21 153:8 166:10 181:

21 182:17 192:13 193:10 194:6,

13 196:21 197:11 204:18 206:15

208:5 209:10 210:7 219:19 241:6,

15 242:17 259:13 278:22 281:7

283:6

patient=s [1] 27:8

patients [218] 10:19 13:1 23:2,19,

20 24:9 26:2,22 27:7,12 34:9 35:4

36:21 37:2,11 38:1,22 40:9 43:15

45:12,17,22 46:1,4 47:8,9 48:1451:3 52:15 53:7,15 58:11 61:13

64:8,9 65:19 66:19 71:15 76:7,14

77:10,12 78:2 79:13 80:3,20 82:

19 86:22 93:3 102:11 110:15,18

111:3 112:2 115:6,9 116:18 117:4,

8 118:7 119:7,18 121:11 123:13

126:5 127:1,20 128:1,5 130:4 134:

4,17 135:21 136:1,15 137:2,5,22

138:11 141:16,19,21 142:2 143:1,

9,12 145:7,11 150:8,17,22 151:11

152:3 153:13,18 154:22 160:1

164:20 165:1,1,3,18 167:5 168:5,

19 174:15,17 175:22 176:2,3 177:

9 178:2,3,5,6,13,19 179:1,3,7,12,

21 181:16 182:1,3,6,8 183:1 184:4 187:9 190:12 191:17,18 192:3,

14 193:6,14,15,16 194:3,7,9,12,17

195:3,10,22 196:8,15 201:22 203:

5,9,10 204:2 207:5,10,13 213:13

214:17 216:2 217:22 218:12 222:

4 224:3 232:12,14 233:1,12 234:5

236:11 238:5 241:17 244:2,7,8

247:16 249:18,20 252:17 259:8,

18 267:20,22 268:4,10,18,20 269:

8 270:10 272:3,5,16 273:8 274:2,

3 275:6,8,14 276:7 277:11 278:19,

19 280:4,7 281:13 282:14 283:8

284:8 285:19 290:5 292:2 293:5

298:11 301:11 311:2,3,8,9

patients= [1] 128:6

pattern [1] 236:15

patterns [2] 64:20 133:11

pause [1] 132:22

pay [1] 288:19

paying [1] 102:17

payment [1] 173:3

PCR[1]

70:11peak [1] 21:16

peaks [1] 48:16

pediatric [12] 4:20 5:1 112:2 115:

1 164:10 180:14 285:14,19 286:

21 287:11 290:4 298:15

pediatricians [2] 289:20 290:4

pediatrics [16] 13:16 112:1 114:

20 154:20 164:3 258:13 285:11

287:22 289:15,19,21 290:11,17

292:22 295:15 300:5

pedigree [1] 240:17

pedigreed [2] 236:12,17

pedigreeing [1] 178:19

peer [1] 50:18

peers [1] 189:5PEG [11] 36:9 84:18 91:20,22 100:

11,18 103:3 104:5,21 151:7 288:1

PEG-interferon [4] 41:3 42:5 287:

21 291:13

PEG-interferon-ribavirin [2] 94:

15 234:5

PEG-ribavirin [2] 84:19 308:4

pegylated [17] 11:12 13:22 14:18

34:14 71:2 73:15 115:22 116:10

118:1,9 130:2 131:10 148:5,10

149:1,3 254:20

pegylated-interferon [7] 287:13,

15 288:5,9 290:14 294:17,19

pegylated-interferon-ribavirin[1] 134:11

penchant [1] 125:21

pending [1] 177:12

penicillin [2] 83:4 251:4

people [128] 4:14 17:18 20:2 22:8,

12 23:1 38:19 47:13 55:16 56:22

86:7,8,14 88:2,11 91:10,19 92:1,4

93:3,4 94:10 95:6,12 98:4 99:3,5

100:10 101:5 102:11,14,18 103:

19 104:8,10,14,17,21 112:14 142:

15 147:4,11,21 148:3,6,10,15,18,

19,20,21 150:9 152:10 171:6,19

172:8,9 186:22 187:11 199:4,15

200:13 201:2,6,17 203:1 205:17

206:1 212:12 214:1 215:7 216:21219:21 220:1,5,16,18 222:10,18

223:7,11 226:5 230:8,22 231:17,

19,21,21 239:20 240:7,12 241:2

242:5 244:12 245:3 258:1 260:17,

21 261:15 264:20 265:19,19,21

266:8 269:14 271:13 273:1 275:

22 276:3 283:9 285:10 288:19

289:1 292:10 296:12 297:19 302:

11 306:3,15,18 309:19,20 310:2,

15 312:10,15,17,20

peopleB-I [1] 223:6

Sheet 18 opted - peopleB-I



peptides [3] 55:10 56:1 182:12

per [9] 10:21 19:6 22:4,14 48:4,5

54:15,17 160:6

percent [79] 30:20 31:8,8,9,9,20

33:7,8,20,21 34:1,3 35:8 43:19 44:

22 45:2 46:14 48:4,5 53:15 54:14,

17 55:3 58:16 64:15 65:9,10,21

66:8,10 71:7,8,9 72:7 74:5 75:21

88:2 109:14 113:15 116:9 117:10,

21,22 121:18 123:20 127:3,21

128:5 136:2 144:15 148:14,15149:5 165:1 174:16 175:17 176:1

181:22 191:21 199:1,6,11 217:11

228:16,16 231:11,18 238:10 240:

14 247:11,14 248:21,22 274:17

286:2 306:17 310:9,10 311:11

percentage [9] 22:9 45:5 91:18

194:17 195:21 286:3,22 307:9,12

percentages [2] 69:14 287:2

perfect [4] 240:17 261:13 305:17

310:13

perfectly [1] 281:14

performed [1] 156:4

perhaps [60] 32:16 52:22 63:6 64:

13 69:8 72:14 85:20 97:6,19 98:2,

15 101:20 111:18 112:17 114:13117:10 122:3 123:6,12 124:14

125:10 131:14 140:1 141:15 143:

9 146:20 147:18 152:17 155:1

156:9 157:18 161:13 163:13,15

169:20 181:9 184:16,17 210:1,5,7,

14 211:9 220:18 222:5 225:21

235:13,17 236:3 240:3 241:8,21

242:12 250:21 253:1 274:2 281:

13 285:12 298:12 307:17

period [25] 22:5 27:12 38:13 39:14

40:11 45:7,18 63:14,21 67:5 68:

12 114:18 115:10 128:3 131:6

133:13 134:10,12 136:13 147:2

157:19 158:21 230:22 238:20 252:17

periodic [1] 141:22

periods [7] 26:10 119:13,17 130:

12 157:17,21 169:4

peripheral [2] 183:16,19Perleson [1] 42:6

permit [1] 164:13

permits [1] 38:7

perplexing [1] 76:19

persistence [1] 57:16

persistently [2] 53:21 70:14

person [6] 48:1 84:19 115:20 147:

2 198:3,5

person=s [1] 53:11

personal [5] 75:14 82:17 104:18198:17 201:22

Personally [3] 77:10 201:7 291:20

personnel [1] 24:1persons [1] 269:10

Perspective [17] 3:8,20,24 9:11,

14 10:13 15:17 82:17 83:19,20 84:

5 106:8,15 107:11 138:8,9 300:8

persuade [1] 167:17

pertinent [2] 62:3,16

perturbation [2] 30:1 31:17

perturbed [1] 56:19

pestiviruses [1] 18:10

Peter [3] 2:8 5:1 242:9

Peter=s [1] 158:3

Ph.D [6] 2:2,9,14 3:3,13,29

Pharm [1] 3:6

pharmaceutical [2] 44:10 210:16

pharmacodynamics [1] 222:13

pharmacogenetics [1] 98:12

pharmacokinetic [4] 260:3 264:7

266:17 285:1

pharmacokinetics[6]

224:17227:14,20 268:12 301:7,14

pharmacologic [1] 50:22

pharmacologically [1] 42:2

Phase [34] 12:20 31:18 32:3,8,15,

17,19 33:15 35:7,10 36:12 37:1

48:11 72:3 94:20 97:6 101:8 114:

14,21 159:21 183:22 184:12 211:

15 212:9 215:22 230:11 232:19,

19,20 257:6 270:13 282:8 305:18,

20

phases [2] 154:12 241:20

phenomena [1] 204:22

phenomenon [1] 65:15

Philip [3] 3:30 186:12,16

phosphorylated [1] 62:8phrase [3] 229:10 232:8 296:18

PhRMA [1] 262:15

phylogenetic [2] 19:19,20

physical [1] 293:15physicians [4] 201:4 207:7 272:

22 310:1

physiologic [1] 47:19

pick [1] 233:17

picture [3] 17:6 28:7 47:16

piece [2] 216:13 293:7

pieces [1] 135:19

piercing [1] 24:19

pike [1] 285:21

pill[1]

291:8pills [1] 291:8

pilot [16] 212:17 216:2 217:20 222:

2 226:22 227:1,10 229:10,13,17

230:3,12 254:6 262:20 263:6 268:

19

pipeline [1] 12:1

pivotal [6] 40:14 41:3 131:21 270:11 309:3 310:12

PK [22] 206:6 222:5,12 225:22 226:

12 227:12 261:20 262:20,22 263:

18 288:16 296:21 297:5 298:4

299:8,10,12 300:9 301:19 305:12,

19 311:22

PK/PD [2] 227:5 285:18

place [8] 33:8 41:15 101:17 177:17,17 276:11 282:6,10

placebo [15] 13:21 77:9,11 78:4

79:15,16 118:12,20 119:3,10,20

130:17 139:6 143:6 150:3

placebo-like [1] 134:10

placed [2] 106:22 277:12

places [2] 20:17 43:21

placing [1] 195:3

plan [3] 235:4 243:2 307:22

planned [1] 232:6

planning [3] 83:14 226:5 307:18

plans [1] 177:15

plaques [1] 10:1

plausible [1] 262:1

play [1] 218:6

playing [2] 69:7 207:2

plea [2] 195:18 311:7

pleasant [1] 231:8

please [7] 4:11 173:16,19 186:13

197:15 216:1 305:9

pleased [1] 198:22

pleasure[1]

50:17plot [1] 31:13

Plough [5] 3:28 174:2,4 179:14

291:16

plunge [1] 107:22

plus [8] 14:18 77:8 94:15,16 103:3

149:4 242:2 287:14

plus/minus [2] 94:14 256:12

point [77] 20:7 26:13 28:6 33:14

37:22 44:8,8,16 45:18 46:18 52:3

63:16 64:2,15 66:8 77:7 85:16 88:

14 97:13,15 98:5 101:2,16 103:10

144:18 146:4 149:18 152:11 155:

6 156:8 157:14 159:6 168:1 171:1

176:20,21 177:15 189:2 191:16

192:15 197:1,2 202:22 203:3 206:14 210:9 211:14 212:17 214:22

223:13 226:20 231:9 232:4 237:

20 239:19 240:2 242:9 244:16

246:21 250:3 253:14,20 254:22

267:4 271:2 288:15 289:6,13 290:

9 292:20,20 298:4 299:2 300:1,20

310:6 311:13

pointed [8] 58:9 66:18 147:5 183:

8,21 191:16 196:6 204:22

pointing [1] 270:17

points [16] 11:3 20:6 43:3 81:10

90:18,19,21 108:6 124:13 165:8

181:1 187:4 203:7 229:22 290:9

310:8politician [1] 146:16

poly-drug [1] 99:4

polyclonal [1] 55:13polymerase [7] 12:8 19:8 94:16

95:17 102:8 145:17 153:7

polymerases [1] 176:10

pool [6] 27:15 28:5 31:22 44:5 79:2 178:13

pooled [2] 34:10 192:19

poor [4] 202:9,9 266:21 275:13

poorly [4] 27:17 76:2 174:22 191:

18

populated [1] 305:21

population [128] 10:16 14:3,12 15:

8 19:15 21:18,18 36:5,9 42:13 54:15 55:5 63:2 65:17 69:19 72:16,

22 73:1,5,10,11 74:21,22 78:11

80:10 88:9 90:10 91:14 94:1 98:7

99:20 108:21 109:15 113:8,12,21

114:2,9 115:3,4 116:15 124:22

138:10,14 145:12,22 146:9 151:9

153:9,17 162:4 163:8 187:7 188:

19 189:1,3 190:13 193:19 194:21

197:11,19 199:14 206:9 209:4,5,

15,20,21,22 210:13 211:6,8 213:8

214:22 216:15 217:4,8 224:19

225:20 227:13 229:14 230:7,13,

14 232:15 233:9,22 234:2,16 235:

4,14,15 236:8,8 237:4,5 238:7

239:15 240:17 243:6,10 248:19

259:13 261:10 262:9,20 264:4

265:3,5 267:5,10 270:18 273:2,13

279:5,9 281:7 286:21 287:5 288:

22 297:18 299:13 300:3,6 304:16

308:20 309:6 311:19

population-specific [1] 305:19

populations[92]

7:4 12:19 13:619:13,14 21:1 22:21 27:10 36:17

45:2 50:10 51:19 64:21 66:14 75:

12,15,17 76:13,15,18 78:10 87:3,

21 88:13 90:11,15 91:4,9 92:2 93:

1,2,7 98:9,13,21 99:6 111:7 117:5,

16 119:12 121:2 134:2,5 135:11

141:5,15 177:4,13,13,16 188:21

189:10 196:21 206:1 208:6 210:1,

20 211:2 212:2,8,18,20,22 213:3

226:1 229:11 230:4 233:15 234:7

237:1,4,16 238:22 242:20 243:21

251:1 262:10 263:21 270:20 285:

14 297:4 298:15 308:8 309:9,10,

16,22 310:3,13 312:2,12,15

populationsB-the [1] 69:14pormise [1] 92:6

portal [7] 47:16 67:13,19 68:1 167:8 195:13 205:1

portends [1] 287:4

portions [1] 25:15

posed [8] 14:8 106:20 107:15 110:

1 111:12 115:12 171:9 216:11

position [2] 243:19 290:3

positive [9] 18:8 23:21 24:11 26:8

117:11 136:14 178:16 229:18 266:

5

positively [1] 293:14

possibilities [1] 169:16

possibility[7]

129:16 144:16 169:22 222:17 239:22 240:4 296:8

possible [25] 80:14 82:1 103:21

107:7 112:13 120:13 123:3 131:

20 136:20 139:5,6,21 189:1 197:4

199:18,20 200:7,9 201:13 207:3

221:14 225:10 281:2 298:7 311:

17

possibly [10] 14:13 52:11 127:22

128:14 129:10 132:17 158:21 159:

1 239:11 296:7

post [43] 13:13 39:16 64:16 68:17

71:14 76:16 77:21 80:9 88:12 93:

5 100:7 127:6 128:3 138:7 144:21

221:17 226:10,10,11 228:9 258:

10 273:6,10 274:7,13,14,16 275:9276:8,12,17,19 277:18 278:9 279:

13,18 280:14,21 281:9 282:8 284:

6,10,18

post-approval [1] 114:18post-market [1] 124:6

post-marketing [5] 114:14 154:

13 212:14 230:22 285:4

poster [2] 104:16,19

postoperative [1] 112:1

potency [2] 165:21 166:1

potent [1] 219:1

Sheet 19 peptides - potent



potential [23] 7:14 8:9,11 44:6,1467:8 69:4 79:13,15 81:11 102:9

162:9 191:9 196:7 204:7,19 219:2

241:11 277:16 279:12 280:11 282:

2 293:11

potentially [17] 81:14 132:14 133:

2,19 162:22 184:5 200:14 209:2,5,

11 210:11 213:18 222:12 246:16

282:12 303:12 308:10

potentials [1] 203:20

power[3]

213:7,9 238:11powered [2] 167:15 302:8

practical [2] 7:14 66:6

practice [1] 311:9

practices [1] 281:17

practitioners [1] 288:19

pre [14] 13:13 68:16 88:12 93:5

111:22 220:19 221:17 258:10 273:

6 275:10 284:5,11,18 293:1

pre-approval [1] 271:15pre-INDs [1] 12:7

pre-intent [1] 279:8

preambles [1] 295:21

precede [1] 277:4

precipice [1] 89:15

preclude [2] 6:16 173:11precondition [1] 281:22

predicated [1] 70:20

predict [8] 29:3 40:9 92:3 124:11

164:6 168:9 181:1 279:1

predictability [1] 268:17

predicted [5] 34:6,20 71:18 82:9

163:16

prediction [4] 34:19 38:9,16 39:

20

predictions [4] 39:8 48:10 49:10

169:19

predictionsB-future [1] 48:21

predictive [6] 28:21 33:4 35:2 40:

16 41:7 123:18predictor [1] 164:1

predictors [4] 38:18 39:5 40:6

177:5

predicts [1] 36:1

predominance [1] 20:17

preexisting [1] 242:14

preface [1] 107:18

prefer [9] 139:18 155:8,12 156:3,4,

6 187:16 189:16 289:16

preferably [1] 187:18

preference [1] 228:2

preferred [4] 121:1 130:3 140:15

155:21

preformed [1] 61:19

preliminarily [1] 72:11preliminary [1] 274:11

premature [1] 124:14

prepared [4] 7:17 9:7 156:9 190:

20

preparing [1] 126:21

prerequisite [1] 197:18

prescribed [1] 116:9

present [7] 9:10 15:16 71:13 126:

9 144:9 160:7 284:7

presentation [9] 56:1 107:17 112:

6 161:5 172:17 180:19,22 183:8

194:1

presentations [1] 271:21

presented [5] 22:16 72:11 94:12

99:14 256:10

presenters [1] 88:2

presenting [4] 11:6 15:12 83:19

184:10

president [1] 174:2

presumably [10] 30:1 49:15 65:13

119:9 152:16 155:9 202:4 247:18

273:20 279:18presume [2] 198:12 306:11

presumptively [1] 282:12

pretreatment [2] 38:18 39:5

pretty [10] 35:2 84:6 85:5 88:18

100:5 105:22 218:18 238:18 273:

1 311:15

prevalence [7] 21:16 24:7,16 77:1

309:5 311:18 312:15

prevalent [2] 20:20 99:6

prevent [6] 81:20 130:9 140:17

279:11,20 282:9

preventable [1] 50:21

preventing [2] 154:1 282:6

prevention [3] 82:10 167:11 282:

22previous [3] 9:5 116:8 236:12

previously [8] 108:2 115:5,20 148:

1,16 237:9 287:17,18

pricing [1] 234:11

primarily [6] 18:22 21:2 194:14

244:14 309:9 311:4

primary [21] 7:1 25:5 77:19 78:7

79:17 82:6 120:4,11 122:19,20

124:5 126:16 127:17 139:11 175:

8,11 232:13 233:4 257:20 263:20

272:21

principal [1] 74:13

principally [3] 65:19 67:6 73:9

principles[1]

219:16prior [18] 23:15 43:14 51:17 59:17

133:11 142:6,9 197:18 268:8 271:

20 272:12 274:7 278:6,15 297:2,4

298:6 301:17

priorities [1] 221:9

prioritize [2] 128:18 276:17

priority [8] 75:15,22 76:17 129:2

194:4 195:6 247:16 253:11

prisoners [1] 23:1

pristine [1] 218:13

probability [2] 70:15 79:21

probable [1] 202:2

probably [42] 20:8,21 30:12 39:2

59:4 77:19 84:17 86:14 87:9,10

93:22 95:8 127:11 136:18 137:11138:6 143:21 152:5 169:3 176:1

179:16 205:13 206:11 210:16 213:

3 227:2 232:18 238:18 244:3 260:

8 263:1,5,17 267:7 268:19 269:15

277:1 278:3 286:19 298:1 307:9,

10

problem [13] 30:19 53:6 67:10 68:

4 96:12 129:6 179:9 221:3 223:2

245:11 274:21 293:17 306:4

problematic [6] 67:15 79:12 80:

12 121:5 241:16 275:12

proceed [3] 91:1 122:2 293:12

proceedings [2] 171:11 313:1

process [24] 22:1 23:17 25:4 28:7

29:19 38:3 44:1 45:8 46:16 54:20

172:12 204:5 215:3 228:12,12

232:3,6 244:4 260:13,19 263:6

281:4 296:6 298:6

processB-is [1] 220:10

processes [2] 96:21 249:7

prodrug [1] 81:5

produce[3]

28:4,6 266:5produced [3] 11:15 56:10,10

product [7] 7:7 13:16 71:2 187:22

248:14 294:10 296:1

production [18] 28:13,14 29:14

30:4,7,9,20,21 31:4,7 32:3 56:16

59:7 60:14 61:18 62:21 63:5 183:

15

productive [5] 27:19 67:18 75:22

77:12 189:18

productively [2] 27:21 28:4

Products [18] 3:10,15,25 6:6,10,

21 8:21 9:6 10:12 11:10 12:2,5 21:

4 50:13 134:22 138:17 177:3 306:

2

Professor [1] 3:17profile [9] 70:1 82:1 83:2 132:18

133:18 194:16 285:22 290:16 308:

7

profiles [2] 179:19,20

program [1] 210:19

programs [2] 86:12 180:10

progress [9] 45:10,22 46:2 54:4

66:20 78:22 88:4 174:13 298:19

progressed [1] 268:5

progresses [1] 46:18

progressing [2] 108:15 220:2

progression [16] 28:22 45:20 46:

6,17 53:5 54:5 74:3 75:1 82:10

126:17 128:7 149:15 259:2 280:5281:12 285:13

progressive [5] 187:8 274:15 284:

8 286:9 306:20

progressors [1] 281:9

proinflammatory [1] 63:4

Project [3] 3:22 83:18 89:1

projected [1] 196:1

prolonged [2] 140:17 153:16

promise [5] 124:6 226:6,11 227:

11,12

promised [1] 263:9

promising [2] 114:21 177:11

promote [2] 57:16 61:14

prone [1] 103:14

prophylactic [1] 182:19prophylaxis [2] 282:22 284:10

proportion [2] 306:15 311:18

proportions [1] 308:12

proposal [1] 263:7proposals [1] 192:11

proposed [1] 276:14

proposing [1] 248:13

prospect [1] 279:8

prospective [1] 254:16

prospectively [2] 215:5 254:14

protease [22] 12:8 85:4,8,13 86:4,

9 91:15,16,20 95:16 102:7,15,16

103:4,13,15 145:17 151:17 153:6

260:5 266:17,19

proteases [1] 176:9

protect [1] 204:18

protected [1] 144:11

protein [1] 61:18

protein-mediated [1] 57:9

proteins [6] 18:19,20,21 55:11 59:

14 61:2

prothrombins[1]

110:22protocol [3] 210:18 215:1 281:10protocols [3] 106:18 122:3 280:20

proud [1] 295:9

prove [6] 96:18 100:21 101:8 124:

7 132:16 134:13

proved [2] 83:4 242:1

proven [4] 61:11 95:17 103:14

283:12

proves [1] 297:18

provide [11] 12:3 16:19 41:8 85:4,

11 86:20 117:15 205:16 214:20

249:1 268:16

provided [3] 28:17 173:14 274:10

providing [3] 86:16,22 142:2

psychiatric [2] 312:11,17pt [1] 126:4

Public [16] 3:27 5:20 15:19 24:8

85:9,10 171:6,15,17 172:12,14,19

173:15 196:17 228:20 298:22

publication [1] 128:3

publications [1] 86:18

publicly [2] 194:18 234:13

published [10] 25:18 26:19 71:21

97:16 129:5 146:3 147:14 148:13

153:20 164:21

Pugh [3] 128:16 129:1,8

purely [1] 70:2

purine [1] 62:11

purpose[3]

137:12 156:7 173:12purposes [4] 65:15 77:5 110:6

213:7

pursue [1] 248:11

pursued [1] 257:7

purview [2] 57:6 234:11

push [1] 300:9

pushed [1] 265:4

put [6] 10:13 92:13 124:8 210:18

235:20 271:5

putative [1] 62:2

putting [5] 35:20 85:13 230:1 240:

21 270:7

Q

qualitative [1] 25:10quality [4] 43:3 82:13 252:3 293:

17

quantifiable [1] 251:21

quantification [1] 286:18

quantitative [1] 25:12

quarter [1] 306:17

quasispecies [3] 19:13 20:9 242:

15

question [72] 14:8 18:13 83:7 111:

6,19 142:11 144:8 145:4 147:7

150:6 154:5,8 155:4 156:1,15 157:

6 158:16 161:8 163:11,18 164:5

Sheet 20 potential - question



166:2,13 167:19 168:14 169:8,13

178:11 179:11 195:15 197:9 198:

1 200:6 208:10 211:14,17 212:1

216:11 220:3,13 221:9 225:13

226:3 233:10 240:12 243:8,14

244:6,19 246:3 247:12 248:8,10

249:9 258:14,19 264:12 265:7

266:20 267:14 269:4 272:11 277:

14 280:15 282:15 284:15,15 292:

16 293:20 305:22 306:1,21

questioned[2]

14:20 15:3questions [29] 12:16,17 15:20 36:

19 95:1 97:1,2 106:20 107:2,14

109:22 111:12 114:12 115:13 137:

21 138:20 142:8,20 144:19 149:

11 154:16 159:4,5 169:7 171:9

195:7 196:19 197:2 200:18

Questions/Clarifications [2] 3:

26 142:5

Questions/Discussion [2] 3:32

196:16

quickest [1] 205:16

quickly [15] 27:21 35:12 46:2 105:

15 108:4 133:3 160:21 195:17

199:18,20 200:7 220:1,14 222:8

281:2quite [17] 48:19 64:7 72:2 77:1 85:

15,18 111:10 160:14 174:12 182:

10 183:6 190:10 282:13 286:5

290:5 291:6 296:5

quits [1] 179:11

quote [1] 49:19

RRAC [1] 84:16

race [2] 71:19 199:11

racial [10] 13:18 76:12 112:19 258:

14 301:22 302:3 303:13,19,22

311:17

radio [1] 89:20

radiology [1] 67:16

raise [5] 101:10 103:16,18 211:7

235:2

raised [7] 149:11 178:7 193:22

223:7 259:5 309:1 310:16

raises [4] 150:1 169:15 201:11

277:14

raising [2] 36:19 210:9

ran [1] 102:19

randomize [1] 297:9

randomized [6] 80:16 218:13 239:

13,14 297:12 298:5

range [4] 27:3 34:3 111:1 301:11

ranges [2] 26:12 141:11

ranging [1] 199:1rapid [12] 31:17 40:5 42:19 63:17

70:8 159:22 183:17,19 209:6 264:

8 271:12 281:12

rapidity [1] 63:15

rapidly [6] 46:19 112:15 187:8 277:

22 278:10 284:8

rare [2] 22:7 65:15

rarely [1] 290:18

rate [33] 27:22 30:12,15 43:10,17

45:1 48:2 54:2,14,16 69:10 72:21

111:18 127:21 128:6 148:13,15

149:4 151:7 184:3 199:6,10 231:

16 237:10 238:9,10 247:10 255:5,

6 256:5 266:3 274:18 310:10

rates [19] 11:15 22:17 43:21 45:4

71:5 73:19,20 143:4 174:21 187:

13 198:22 240:13 249:16 256:1

271:22 275:8 291:12 294:1 302:

20

rather [13] 70:3 114:4 121:21 211:

22 212:5 225:19 237:12 240:20

242:1 257:19 273:11 299:4 308:

15ratio [1] 188:20

rationale [2] 81:13 260:20

ravage [1] 112:11

Ray [8] 16:7,8 89:19 151:2 220:18

233:18 251:12 281:5

Raymond [2] 2:16 7:18

re-emergence [1] 162:10

re-prove [1] 122:13

re-transplantation [1] 276:3

reach [5] 33:14 279:3 309:15,22

310:3

reaches [1] 86:13

reaching [1] 195:12

read [5] 6:12 89:8 171:18 172:9

245:4readily [4] 53:17 54:7 184:4 251:

21

ready [2] 206:16 241:21

real [12] 20:15 42:20 43:2 188:4226:10 237:7 250:4 282:4 289:11,

11 292:9 295:17

real-live [1] 312:19

real-world [1] 189:4

realistic [3] 189:2 260:11 263:1

reality [4] 269:13 289:12,14,19

realize [5] 101:18 188:6 189:4 242:

18 308:6

really [73] 17:2 21:22 32:12 35:19

37:20 39:19 52:3 63:19 65:4 79:8,10 82:15 92:11,14 95:20 97:14

118:3 127:19 136:10 144:20 145:

1 151:10 154:9,21 158:2,13,16

159:16 160:11 162:12 163:13 166:

4,8 174:6 184:1 190:19 193:5 195:

2,7,19,22 196:3,8,11,12 200:10

201:17 202:3,16 214:6 218:22

219:18 225:16 234:21 239:2,13

240:11 242:3 253:13 272:13 273:

7 274:11 275:15 287:3 290:3 293:

14 294:16 296:11,19 304:13 305:

18 311:12 312:13

reason [17] 70:4 109:4 127:11 129:

2 151:19 172:18 197:21 199:2

204:7 206:22 217:10 255:14 265:10 281:1 283:8 303:2 304:17

reasonable [12] 120:14 129:12

133:1 166:10 212:10 217:14 242:

7 244:11 246:5 257:10 262:5 285:

22

reasoning [1] 119:4

reasons [9] 35:16 125:20 146:11

165:3 184:19 265:17,22 298:22

300:3

Rebitrone [1] 180:14

rebounds [2] 42:9 135:22

receive [3] 109:9 138:12 141:17

received [11] 23:14,18 85:9 116:8

118:20 148:11,22 149:3 191:20,

21 214:21

receiving [1] 77:14

Recent [4] 21:14 39:22 40:4 98:1

recently [1] 71:21

receptor [1] 12:10

receptors [1] 59:11

recess [2] 106:5 258:4

recessed[1]

171:12recipients [2] 136:16 146:1

recite [1] 7:14

recognition [3] 44:13 190:13 301:

8

recognize [10] 47:8 52:8 80:12 87:

19 181:7 188:8,19 189:6 283:4

295:16

recognized [3] 26:1 188:14,18

recognizing [1] 76:18

Recombinant [1] 25:8

recomendationB-that [1] 137:5

recommend [1] 93:8

recommendation [3] 137:4 232:9,

21

recommendations [3] 87:17 185:4,7

recommended [8] 134:12,19 139:

5 141:14,19,21 196:22 249:4

recommends [1] 24:5

reconvene [6] 106:4 171:5,12 258:

2 312:4 313:2

record [5] 6:16 9:2 100:6 104:6

198:18

recorded [1] 123:19

recording [1] 173:12

recurrence [4] 160:20 161:2 276:

1 279:17

recurrent [7] 74:3,15 80:9 274:8,

16 276:8 279:11recurring [2] 122:9 135:21

recurs [1] 279:13

red [1] 65:6

reduce [8] 51:4 127:6 169:22 183:

15 184:16 255:7,15 256:3

reduced [8] 82:11 126:19 149:14,

15 162:16 178:22 255:17,18

reducing [7] 127:5 131:14 152:18,

19 236:4 255:8 256:3

reduction [11] 58:12 59:15 116:2

127:4 129:14 153:5 167:7,12 168:

19 237:12 238:20

reductions [2] 150:21 236:3

reemerge [2] 144:4,12

reemphasized [1] 54:21Reese [6] 2:3 3:6 5:9,9 6:11,14

referenced [1] 256:10

referred [2] 150:14 218:16

referring [3] 151:13 159:16 272:

16

refers [1] 116:19

reflect [1] 188:20

reflected [1] 95:5

reflex [2] 277:11 307:2

reframe [1] 198:1

regard [8] 13:5,20 14:7 15:3,4 60:

21 67:8 162:18

regarding [12] 69:1 78:14 82:19,

21 98:10 111:6 138:21 185:16

189:11 234:6 244:5 277:15

regardless [1] 208:12

regeneration [4] 28:1,2 43:13 67:

1

regime [1] 189:15

regimen [20] 14:14 78:18 81:16

121:12 124:13 134:9 150:16 158:

14 159:15 191:13 193:8 208:13249:5,19 253:5,17 256:14 266:20

278:12 303:7

regimens [14] 63:10 77:9 115:21

151:8 159:9,18,18 162:18 163:4

194:5 195:21 207:12 275:3,4

regions [3] 204:3,8 225:7

register [3] 172:7 177:2 285:6

registered [1] 249:3

registration [21] 211:15 224:4

226:10 229:19 232:13 233:16 237:

6 239:15 243:18 244:18 258:20

262:21 265:9,11 270:17,21 278:6

281:3 283:15,22 296:8

registrational [12] 114:8 138:12

221:21 222:8 223:15 225:20 227:7,9 263:4 288:18 295:17 297:16

registrationB-initial [1] 243:17

registry [1] 146:1

regular [1] 150:19

regulated [1] 8:16

Regulatory [7] 3:23 106:8,14 107:

10 138:8 177:7,11

reinfected [1] 152:20

reinfection [3] 144:17 282:6,10

relapse [11] 65:8 75:9 121:19,19

127:3 147:4 160:3,4,14 192:14,18

relapsed [3] 190:11 192:6 237:10

relapser [1] 235:18

relapsers[7]

76:9 116:21 117:10,19 139:1 192:18 240:7

relapsers/rebounders [1] 116:

22

relate [2] 61:4,6

related [16] 7:2 10:11 12:7,17 18:9

20:4 21:3 49:1 73:8 88:15 158:18

258:13 268:12 273:12 309:8 310:

8

relates [1] 166:13

relation [1] 22:11

relationship [5] 163:20,22 164:9

172:21 264:4

relationships [5] 173:8,9 250:19

263:14,17

relative [2] 48:15 309:5relatively [10] 45:17 50:3 67:5 68:

16 127:12 187:3 202:9,9 271:22

286:8

relearn [1] 190:8

release [2] 183:16 283:5

released [1] 267:10

relevance [1] 51:16

relevant [7] 25:4 26:21 90:5 185:

15 235:1 291:6 312:19

reliance [1] 228:21

reluctance [1] 154:11

Sheet 21 question - reluctance



reluctant [2] 223:12,13

remain [8] 28:15 54:22 142:13 144:

11 175:19 190:4 191:13 193:8

remained [1] 104:18

remains [5] 22:10 32:12,21 144:9

151:22

Remarks [7] 3:2,7 4:2 9:11,13 108:

5 137:14

Remember [6] 27:22 74:21 145:

21 164:19 237:21 267:4

remembered[2]

123:22 139:12remind [2] 11:22 243:7

reminiscent [1] 82:21

remission [1] 161:15

remodeling [1] 167:12

removal [1] 253:1removed [2] 153:16 217:16

renal [5] 76:22 80:20 81:1 135:12311:2

repeating [1] 126:2

repetition [1] 109:2

replace [1] 247:8

replete [2] 135:17 165:18

replicase [1] 135:5

replicate [2] 19:4 52:11

replicating [1] 160:7replication [19] 18:11,14,21 52:12

56:17 58:5 59:15 62:13 63:19 68:

6 110:9 144:11 153:5 154:6 161:

13,13,20 170:2 184:22

Replicon [1] 176:11

reported [2] 19:8 194:22

reports [3] 32:18 151:5 252:4

represent [7] 8:17 107:6 117:4

198:15 232:15 304:20,22

representation [1] 13:17

Representative [9] 2:9,11,17 8:

13,15 16:12 84:16 138:10 309:11

represented [2] 81:22 114:3

represents[5]

18:18 20:12 107:13 183:19 184:1

request [3] 8:5 154:15 300:15

requesting [1] 186:11

requests [1] 214:21

require [11] 96:16 193:16 226:7

238:14 245:10 247:6 264:21 265:

8 271:14 288:16 298:6

required [12] 73:17 96:4 150:21

166:17 171:18 235:11 258:20 272:

5 284:16,22 301:13 302:21

requirement [5] 205:18 232:22

260:9 297:1 303:21

requirements [3] 245:1 288:8

296:21

requires [1] 262:14requiring [8] 82:12 193:18 206:12

226:12 245:14 246:16 272:14 302:

9

rescue [2] 78:22 204:6

RESEARCH [6] 1:3 5:18 6:19 96:

12 174:2 272:22

researched [1] 234:17

researchers [1] 105:16

resemble [1] 106:21

reserve [1] 115:1

reservoirs [1] 100:9

residual [5] 66:10 128:19,20 145:

3 161:22

resistance [41] 81:20 95:15,19 96:

1 97:8,8,11 102:2,3,9,13,15,20

103:12,14 118:18 130:11 132:9

133:11,16 135:6 158:20 159:2

176:12 179:10 190:5,6 193:7 200:

3 209:7 220:15 236:5,7 239:22

240:5,22 241:10,10 266:21 267:

11 308:2

resistant[2]

103:19 242:15resolution [3] 45:1 108:20 114:12

resolve [3] 44:22 45:3 169:2

resource [1] 86:11

respect [10] 8:12 9:3 147:19 153:3

203:21 204:20 217:11 228:10,18

280:18

respectB-it [1] 231:5

respectfully [1] 217:20

resplendent [1] 59:19

respond [23] 29:5 37:2 38:19,20,

21 39:1,7 40:10,10 92:4 98:13,13

147:4,8 157:9 178:6 183:2 199:9

203:12 220:5 249:21 278:16 304:

17

responded [6] 107:1 109:22 148:16,17 192:6 237:9

respondents [3] 107:13 109:22

132:6

responder [3] 235:18,18 239:7

responders [9] 42:19 116:20,21

175:18 193:5 236:21 238:13 239:

21 240:16

responding [3] 150:1 153:14 168:

13

response [127] 29:4 31:3 35:14 36:

1 37:16 38:2 39:9 40:6 51:12 52:

17,18 53:12,13 55:9,12,13 57:15

58:20 59:1,13 60:8,12,16 61:6 63:

7,11,17,17,18 64:3 65:4,7,8,18 68:7 69:7,10 70:9,10,13,14 71:5,12

72:4,7,8,10,15 73:4 75:8,11 76:9

98:17 101:7 111:18 112:17,22

113:5,14 114:15 116:19 117:20

120:18 123:17 125:1 139:18 143:

10,18 147:6 148:12,15 149:4 154:

16 155:8 156:1 157:13 161:11

162:3 163:17 164:7 174:21 175:3

177:6 181:13,20,21 182:4,10,15,

16 184:3 187:13 191:19 192:1,4,5

198:22 199:6,10 200:22 202:11

227:8 231:16 235:15 236:15 237:

10 238:9,10,18 240:13 247:10

248:21,22 249:16 255:5 256:5

257:9 266:2 275:8 284:5 286:16291:12 294:1 297:5 302:20 308:7

311:15

responseB-not [1] 202:9

Responses [26] 3:23 13:3 15:18

36:21 37:4 106:7,14,16 107:2,5

108:1 117:13 138:22 170:4,16

175:4,5 181:16 182:10 185:2 187:

15 188:15 203:19 243:3 307:20

308:4

responsible [1] 59:16

responsive [2] 57:3 69:15

responsiveness [4] 21:3 53:1 72:

13 262:6

rest [2] 18:20 258:6

restrict [1] 265:10

restricting [2] 240:4 268:3

restrooms [1] 4:15

result [7] 10:21 29:13 30:7 33:9 42:

13 54:11 85:9

results [6] 29:14 42:16 55:8 134:

16 291:18 312:19

resumption[1]

128:2Retanovir [1] 266:18

retard [1] 81:20

retarding [1] 154:1

retesting [1] 141:14

retreated [3] 149:22 193:16,19

retreating [1] 192:2

retreatment [9] 118:1 134:8 143:4,

8,18 147:6 158:22 192:4 237:11

retrospectively [2] 195:9 254:13

return [1] 170:20

reversal [1] 128:20reverse [1] 280:4

reversing [1] 126:18

review [2] 15:10 25:2

reviewing [1] 12:6revolutionary [1] 73:4

ribavirin [48] 11:11,13 13:22 14:20

29:21 34:14 51:11 62:3,7,19 63:3

71:2,3,7 79:11 81:4,5,6,15 84:18

91:22 100:12,12,16,22 103:4 104:

5,21 115:22 116:9 118:2,9 132:4

140:18 148:9 149:4,10 253:6 255:

8,13,16,22 256:12,21 261:4 275:

18 287:14 291:13

ribavirin-Bfour [1] 73:15

ribavirin=s [2] 81:1 132:6

ribosomal [1] 18:18Richard [6] 2:7 5:11 7:19 229:10

257:5 303:3rid [3] 231:3,10 298:21

rigor [1] 156:6

rigorous [1] 218:14

risk [43] 23:11,13 24:7,12 28:22 70:

1 75:1,3 88:3 102:12 127:13 144:

16 146:9 150:12 166:18 167:13

168:19 177:12,16 192:18 194:15

195:4 200:13 201:15 210:13,20

211:1 216:15 219:21 220:2 232:

15 235:7 236:5 240:22 241:7,9

266:21 268:2 279:19 281:11 287:

3 298:11 309:5

River [1] 20:19

RNA [12] 18:8,17 19:8 26:8 40:18

72:1 116:2 120:20 135:4 144:10175:19 282:14

RNA-dependent [1] 19:8

RNAs [3] 25:10,12 136:12

road [1] 297:6

Robert [2] 2:9 49:20

robust [7] 55:16 69:3 70:14 79:17

182:4 183:18 290:18

role [7] 8:16 29:3 32:10 54:5 55:19

69:7 185:17

Ron [1] 5:6

Ronald [1] 2:12

roof [3] 104:22 105:2,4

Room [7] 1:10 4:16 8:3,6 84:14

216:17 289:13

rotating [1] 9:18

roughly [1] 18:2

route [2] 112:3 254:16

routine [2] 24:5 137:6

routinely [1] 277:18

rsistance [1] 105:20

rule [2] 45:21 71:13

rules[7]

38:16 39:15,18,20 41:7,10 70:18

run [3] 188:17 300:14 312:16

running [1] 152:7

RVR [5] 123:7,21 130:8 165:8 240:

18

RVR4 [5] 123:14 130:13 134:21

139:19 140:16

Ryan [2] 88:15 89:3

SSAE [2] 82:1 83:2

SAEs [1] 204:6

safe [6] 50:21 83:4 154:6 163:12

229:5,13

safely [2] 268:21 269:8safer [2] 209:4 249:1

safety [59] 24:9 80:14 91:8 93:1 96:

7,9,9,18,20 98:6 104:11 109:12

130:18 132:18 134:20 143:10 145:

8 150:7,11 177:5 179:19 197:21

198:2 205:22 206:2,5 210:7 212:

13,21 214:3,8 224:13 225:10,22

226:12 228:5,11 232:18 233:2

246:22 249:14 263:18,20 264:1,1

267:20 271:6,13 274:2,5 275:3

285:22 288:10,16 290:11 292:9

296:22 298:4 301:19

sake [3] 91:17 227:3 235:19

salient [2] 108:6 310:8

salt [1] 107:11

salutary [1] 153:8

salvage [1] 102:18

same [52] 17:3 28:16 30:12 33:8,

17,20 69:20 71:14 80:17 92:1,2

95:14 104:20 112:22 115:22 122:

15 128:6 142:22 155:20 156:15

157:6 158:22 163:8 164:17 175:4

201:12 202:8 208:13 220:8 221:

15 230:19 232:5 249:15 251:3

252:17,18,20 253:2 255:12 262:3

271:18 279:19,21 287:3 290:15

299:12,19 300:1,2,4 301:6,9

sample [6] 42:21 121:9 303:9,15,

21 305:2samples [2] 34:15,16

sampling [13] 40:8 42:10,10,12

122:6 125:21 138:11 139:17 156:

6 164:13,15 166:6 210:5

San [1] 5:12

Santa [1] 123:2

satisfied [7] 133:16 156:20 157:1

208:22 216:12 226:4 263:6

save [1] 261:11

saved [1] 261:8

saw [6] 36:20 52:20 54:13 127:18

140:22 169:10

Sheet 22 reluctant - saw



saying [21] 40:17 44:7 104:15,20

107:3 121:22 127:19 177:20 199:

21 209:12 225:3,16 254:8,14 271:

14 275:2 294:4 295:11 296:14

302:15 305:5

says [3] 103:1 226:8 306:8

saysB-the [1] 149:6

Sc.D [1] 2:5

scar [2] 47:6 67:1

scenario [2] 262:1 276:6

scheduled[1]

4:13schema [1] 20:2

scheme [1] 19:16

Schering [4] 174:2,4 179:13 291:

15

Schiffman [1] 148:14

School [1] 5:20schoolB-the [1] 290:19

science [1] 190:21

scientific [2] 86:21 146:1

scope [1] 12:13

score [12] 79:20 125:6 129:8 146:

7,8 204:9,11 278:22 279:2,3,7

280:4

scores [2] 145:21 225:6

scoring [1] 128:13screen [2] 53:10 76:18

screened [2] 7:11 23:12

screening [6] 23:21 24:5,6 25:6

26:16 53:18

se [1] 160:6

seats [1] 258:1

Seattle [1] 4:21

second [21] 32:17 33:15 35:10 45:

12 54:12 58:6 76:10 79:18 107:10

150:6 158:18 163:18 183:22 184:

12 193:21 198:20 202:13 230:8

274:14 279:15 283:12

second-string [1] 200:9

secondary[7]

82:8 120:14 125:16,19 126:21 140:3 166:20

section [1] 196:18

see [81] 4:18 17:16 18:2 19:11 20:

15,19 25:19 26:4 31:5,17 33:6,19

34:16 37:22 42:16 47:18 48:16 50:

18 53:10,20 54:1,19 58:6 61:1 71:

11,19,22 73:18,19 106:13 108:1,

15 110:5 115:8,19 131:1 137:11

142:10 148:18 153:13 155:2 168:

9 172:8 176:12 183:17 184:11

197:5,19 202:5,10 204:1 206:5

208:11 209:8 210:4 213:9,10 214:

12 216:2,17 218:12 224:15 227:

11 228:3,15 232:3,4 254:8 255:10,

21 260:9 266:10 270:2 279:10285:18 286:5 290:21 291:3 305:

19 312:9,22

Seef [46] 2:18 5:17,17 147:8,10

152:1 167:3,20,22 198:7,8,20 202:

14,19,22 203:10 219:17,18 222:15

223:5,18 230:17,18 233:16,18

237:2,3 239:17,18 247:7 248:7

255:1,2 256:2 273:14 283:3,4 284:

14,22 293:20 295:19,22 297:7

306:6,7 310:14

seeing [2] 135:22 150:19

seeking [3] 12:3 77:13 250:12

seem [4] 29:2 128:4 240:16 285:

21

seems [12] 32:13 39:3 111:10 126:

19 212:10 230:1 250:16 256:8

257:10,18 273:3 298:14

seen [16] 20:22 28:16 53:5 57:21

66:21 74:6 104:16 114:16 119:9

137:5 151:22 241:17 271:20 272:

12 287:3 310:11

sees[2]

45:14 53:15segments [1] 51:22

segregated [1] 74:22

segue [1] 106:10

select [3] 12:22 84:9 279:5

selected [2] 194:11 204:1

selection [4] 51:18 78:14 82:19

242:14

semi-normal [1] 47:1

Senate [1] 89:5

senescent [1] 32:10

sense [20] 41:4 75:14 90:9 98:21

145:9 160:4 162:8 165:9,21 166:9

178:5 221:9 234:18 238:6 245:9

256:13 257:3 267:16 268:20 270:

1sensitive [7] 25:9 34:22 86:17

112:12 124:10 144:22 192:22

sensitivities [1] 41:22

sensitivity [1] 25:7

sent [1] 12:16

separate [12] 87:17 112:11 192:19

212:21 213:6 224:8 237:1 249:7

279:12 280:22 302:21 306:11

separated [2] 237:19 302:21

separately [3] 192:4 225:8 258:18

separation [1] 303:2

seque [1] 305:17

sequence [3] 19:16 25:15 212:3

sequential[1]

169:15serial [1] 102:6

series [5] 67:11 168:14 197:2 203:

1 254:2

serious [9] 76:20 88:4 145:11 167:

13 175:1 199:16,17 200:14 230:

20

seriously [5] 88:8 91:5 92:12 214:

1 231:19

serotype [1] 18:11

serum [6] 32:6 58:4 61:16 63:13

129:14 183:11

serve [3] 13:22 17:1 18:22

served [2] 180:13 186:19

Service [1] 9:20

SERVICES [1] 1:1SESSION [3] 1:5 172:15 227:3

set [13] 31:15 55:9 56:9 84:6 94:10

104:9 105:19 147:10 154:9 204:

13 242:6 287:6 290:3

sets [2] 68:19 251:22

setting [16] 41:8 50:6 150:20 160:

19 165:15 166:9 169:10 183:3,4,9

186:6 206:11 210:6 267:12 276:

18 277:19

settings [1] 161:1

seven [6] 26:7 148:4 175:17 176:2

182:20 291:7

several [6] 34:11 57:12 72:20 168:17 171:6 274:19

severe [7] 81:1 83:1 112:4 150:9

151:18 286:14 300:7

severely [1] 153:17

severity [8] 29:3 46:15 127:6 218:

2 285:14 286:10 298:11,14

sex [2] 24:10,10

shame [1] 179:2

share[6]

105:10 139:21 157:2 209:19 230:11 271:22

sharply [1] 128:7

Shering [1] 3:28

Sherman [177] 2:2 3:3,13 4:3 6:11

7:20 9:9,22 10:8 11:6 15:12 16:1,

4,16 52:21 54:12 58:9 68:22 83:

15 84:6 106:3,6 142:6 143:17 147:

9 150:6,11 151:20 153:2 155:4

156:7 157:8 158:1,9 159:3 160:15

162:20 164:12 165:22 166:5 167:

20 168:12 169:13 171:1,16 174:

11 180:2,4 183:7 186:10,15 190:

16 196:17 198:7,18 202:12,15,21

203:6,14 205:5,9 206:17 207:15

208:7,17,19 209:18 211:3,12,20212:15 213:11 215:9,11 216:6,16

217:3 218:5 219:17 221:19 223:

20 225:12 226:16 227:22 229:8,

20 230:17 232:7 234:9,20 236:16

237:1 238:2 239:9,17 240:9 241:3

242:8 243:7,22 245:12,22 246:14

247:1 248:1,9,16 249:8 250:6,9,

15 251:9,12 252:15,19 253:12

255:1,20 256:7 257:4,9 258:5 260:

14 261:17 262:17 263:10 265:2,

12,16 266:6 267:3 268:1,6 269:11,

21 270:1,6,8,22 271:4,10,18 273:3,

18 276:22 278:5,18 281:5 283:2

284:4 285:11 288:2,7,11 291:12,18 292:3,15 298:8 300:11,19 301:

16 302:18 303:16 304:5,8 305:9,

16 306:6 307:14 308:5,22 310:6,

20 311:14 312:21

Sherman=s [5] 57:22 58:14 83:8

161:17 180:19

shooting [1] 104:3

shopping [1] 206:19

short [17] 37:18 38:12 40:11 45:18

50:3 67:5 68:16 96:18 107:20 119:

13 135:9 160:18 161:4 166:6 205:

2 240:18 282:17

short-term [2] 79:21 243:2

shorten [3] 184:16 252:10,12

shortened [2] 229:7 255:3shortening [2] 251:19 252:11

shorter [9] 14:17 131:12,14 139:7,

9 157:21 168:22 169:4 264:7

shortest [1] 163:14

shot [6] 104:22 105:2,4 119:6,7

139:16

shouldn=t [7] 248:11 257:1 270:

12 281:22 304:2 309:17 312:2

show [27] 10:15 11:22 26:20 34:9,

19 35:10 46:22 60:9 66:6,9 68:17

72:11 73:7 89:20 120:17 165:1

174:10 227:5,17,18 229:11 238:8

248:21,22 256:15 264:6 302:12

showed [10] 22:4 31:16 40:7 41:9

42:6 48:14 59:17 167:7 217:3 269:

6

showing [6] 36:11 41:3 60:13 136:

14 252:13 288:10

shown [26] 17:22 21:21 44:21 54:

12 55:2 59:9 60:9 62:19 65:6,12

69:2,13,15 71:5,10 73:16 108:21

109:1 123:6 144:14 168:22 175:14 184:8 254:12,13 286:15

shows [8] 21:15 34:19 40:14 70:

12 146:5 181:19 229:13 275:7

showsB-we [1] 146:2

Shreveport [2] 5:7,8

shunting [1] 204:22

shut [1] 31:8

sick [2] 150:18 189:19

side [13] 123:15 153:9 163:13 196:

1 200:2 203:20 209:8 213:12 222:

1 255:15 290:15,20,20

sign [2] 172:4 173:17

signal [2] 25:11 305:20signaling [2] 59:13 72:13

signature [1] 56:10signed [4] 171:7,20 173:18 186:11

significance [1] 21:1

significant [10] 17:17 22:9 33:10

67:4 71:10,11 129:6 147:16,22

238:19

significantly [2] 34:6 169:22

signs [2] 48:2 229:11

silence [1] 127:9

silent [1] 127:11

Silver [1] 1:11

similar [13] 14:16 28:16 37:1 41:1,

4 78:8 80:18 81:8 83:10 161:5

186:6 256:1 270:8

similarly[5]

25:12 26:11 37:3 276:22 290:21

simple [2] 164:17 238:11

simplified [1] 28:8

simplifying [1] 235:19

simplistic [1] 218:11

simply [6] 30:8 39:6 154:16 165:

16 176:10 255:13

simulate [1] 59:11

simultaneous [1] 244:13

simultaneously [4] 45:15 187:18

278:7 300:14

since [17] 16:5 51:12 79:7 85:15

113:2 143:11 155:18 159:1 163:

22 174:5 191:5 198:4 220:22 246:

8 247:10 256:14 271:14single [7] 51:14 179:9 202:17 242:

13 257:14 275:17 281:13

single-agent [4] 179:6 209:9 235:

6 238:16

single-arm [1] 239:14

single-stranded [1] 18:8

sirolomus [1] 278:1

sit [1] 186:20

site [2] 18:18 144:11

sites [1] 57:13

sitting [2] 95:7 214:2

Sheet 23 saying - sitting



situation [5] 31:13 87:13 88:6 214:

19 219:9

situations [1] 137:6

six [15] 20:2 26:14 27:7 42:21 54:

14 84:15 87:1,8 92:14 108:2 110:

10 149:5 175:18 187:3 252:20

size [4] 218:7 303:9,21 305:2

sizes [2] 213:8 303:15

skepticism [1] 230:11

skews [1] 60:15

skip[1]

112:7slap [1] 240:1

sleep.@ [1] 49:22

Slide [165] 10:14 11:3,8,21,22 12:

12 13:4,19 14:6,8 15:2,9 16:17 17:

5,14,20 18:6,15 19:3,18 20:14 21:

5,13 22:2,3,15 23:10 24:3,21 25:

16 26:18 27:13 28:11 29:8,18 30:

3,18 31:11 33:1 35:3,15 36:2,7,15

37:17 38:4,14 40:13,22 41:6 43:5

44:18,20 45:19 46:9,20 47:22 48:

8,20 49:3,9,18 50:16 51:6 52:6 53:

8,9 54:10,13 55:6,18 57:4,11,20,

21 58:2 59:2,17,18 60:4,20 61:7,

22 62:6,18 63:8 64:17 66:4,16 68:

20 70:6,7,19 71:16 72:18 73:1274:1,9,16 75:13 77:2 78:1,9,19 80:

8,19 81:9 82:14 83:8 84:2,10 86:3

88:15 89:13 90:17 96:5 98:8 99:

10,13 100:3 102:1,22 103:1,22

105:21 106:12 107:16 108:8 109:

6,20 110:2 111:5 113:4 114:5,17

115:11 116:11 118:4,22 119:22

120:16 122:18 124:15 125:15,22

127:8 128:11 129:17 131:9,17

132:3 133:5,8 134:3 135:1,13 136:

22 137:13 138:13 139:10 140:12

141:8,9 156:17 174:11

slide-Bwe [1] 145:20

slides[5]

21:15 52:20 66:21 92:1394:13

slightly [1] 23:7

slope [10] 31:22 32:11 33:15 36:12

58:4,6,7,11 164:17 184:15

slow [2] 27:11 263:5

slower [1] 124:9

slowing [1] 126:17

slowly [2] 46:1 286:9

small [11] 20:10 29:22 42:9 65:12

84:14 153:22 160:18 241:12 246:

16 296:22 300:4

smaller [6] 225:22 226:7 263:18

264:5,22 288:17

smallerB-the [1] 222:1

sNDA [1] 180:14so-called [2] 134:1 235:17

societal [4] 48:18 49:6,16 276:10

society [1] 16:20

socioeconomic [1] 194:16

softer [1] 99:19

sold [1] 234:18

sole [2] 26:16 253:19

solely [4] 61:4 71:1 159:17 161:19

solicit [1] 118:3

solid [1] 136:21

someB-again [1] 119:14

somebody [4] 218:7 219:11 239:

12 240:17

somehow [4] 199:2 230:19 237:

14 272:2

someone [9] 146:19 197:15,21

212:5,6 221:10 240:21 248:10,13

sometimes [2] 42:20 156:2

somewhat [5] 42:3 107:12 116:17

119:10 155:18

somewhere [1] 199:10

soon[8]

103:20 139:15 207:3 220:17 221:14 228:5 229:3 231:20

sooner [1] 299:4

sophisticated [1] 62:1

sorry [2] 107:18 202:15

sort [12] 32:21 39:16 59:21 104:2

106:10 137:4 163:7 209:2 215:1

252:7 266:19,22

soul [2] 119:19 129:13soul=s [1] 127:21

sounded [1] 156:20

sounds [1] 225:15

source [1] 121:10

sources [2] 88:19 258:9

Southeast [1] 20:18

Southern [2] 190:17 191:3Southwest [1] 204:10

speaker [5] 83:16 172:6,19 180:3

190:16

speakers [3] 142:12 173:18 191:

15

speaking [5] 4:8 52:1 95:6 173:11

286:8

speaks [1] 164:2

special [19] 7:18 52:14 75:12 76:

13 78:10 135:11 141:5,15 195:6

222:6 226:1 229:11 230:3 263:21

270:20 276:13 284:20 289:4 297:

4

species[1]

19:12Specific [27] 8:1 29:22 48:21 56:5

59:22 60:2 159:13 161:1 171:8

182:12 188:1 196:19 204:3 207:

16 229:14 233:7 240:10 243:8

246:19 247:4 251:11 252:9 257:

10 258:14 275:6 304:5 311:22

Specifically [9] 13:5 181:11 188:9

207:21 248:17 250:18 272:11 284:

18 306:13

specifications [1] 111:4

specificity [2] 25:7 125:20

specifics [1] 159:17

specified [1] 133:13

specimens [2] 67:10,11

spectrum [3] 111:21 147:20 275:4speculate [1] 158:11

speculating [1] 159:8

speculation [2] 91:17 161:8

speed [1] 298:6

spell [1] 173:13

spend [1] 112:19

spent [1] 84:15

spinning [1] 193:10

spirit [2] 161:7 180:6

spoke [1] 198:22

spoken [2] 106:1 127:10

sponsors [5] 7:9 12:4 95:21 155:

22 306:2

spontaneous [3] 53:11 108:20

286:17

spontaneously [2] 55:17 56:22

Spot [1] 181:19

Spring [1] 1:11

spur [1] 191:7

squirming [1] 258:1

stability [1] 27:7

stable[1]

189:9STAFF [2] 2:21 9:8

stage [21] 50:6 54:4 67:3,13 69:9

101:14 111:7 113:9 125:5 154:9

167:5,11,11,12,12 197:8 202:16

203:15 211:21 243:4 268:9

stages [9] 32:13 45:10 47:14 69:9

153:19 189:1 203:17 214:10 246:

10

staggering [1] 158:6

stain [1] 47:4

stalking [1] 144:7

stance [2] 210:14 262:19

stand [2] 92:18 93:20

standard [77] 11:12,14,17 13:21

14:11 36:5 40:2 51:12 59:6 64:570:5 73:14 75:9 76:3 77:8 85:19

86:1 94:13 101:13 103:3,7 109:7

111:17 113:3 118:11 129:21 130:

20 131:4,11,21 132:2,15 134:7,8,

18 139:4 140:15,21 143:2,7,10,15

147:6 148:22 149:3,21 156:18

157:2 166:16 169:10 189:14 201:

18 203:18 207:22 209:11,13 240:

19 242:2 252:11,20 253:5 262:7

264:17 269:7 275:5,9,12,13,16

276:19 278:16 287:8,11,12,13,16

292:22

standards [2] 189:18 217:16

standpoint[5]

66:6 236:7 242:10252:3,8

stands [1] 232:8

star [1] 57:13

stark [1] 182:9

start [30] 4:19 17:6 33:4 44:5 79:

10 97:4,6,11 110:4 136:14 142:9,

14,18 158:6,7 173:19 180:21 186:

12 195:22 196:9,21 197:7 203:8

212:4 214:11 233:18 251:4 258:

16,21 261:20

started [5] 85:2 92:11,12 106:6

233:8

starting [7] 16:7 31:16 33:8,19

110:4 169:20 193:2

starts [3] 45:12 54:11 121:9STAT [1] 59:12

state [23] 28:19,21 29:10,14,16,17

30:2 43:14 53:6,14,19 80:4 144:5

151:9 162:5 173:19 219:4,7,12

274:6 279:8 282:17 283:17

stated [5] 199:10 216:20 259:1

262:19 281:15

Statement [13] 3:5 6:12,13 9:7

171:18 172:10,20 173:6,10,15

194:7 211:5 269:5

States [12] 17:16,22 20:18 22:8 74:

14 79:2 97:20 113:12 208:14 245:

19 280:9 304:1

statistical [1] 156:10

statistically [3] 71:10,11 245:16

statistician [2] 5:20 213:1

statistics [1] 155:17

status [1] 153:15

staunch [1] 112:10

STDs [1] 24:9

steady [9] 24:10 28:19,21 29:10,

14,16,16 30:1 43:13steatosis [1] 46:5

steeper [1] 36:11

stellate [1] 53:2

stems [1] 12:15

step [3] 17:12 95:3 207:19

stepped [1] 177:20

steps [1] 50:18

Stewart [1] 26:19

still [30] 17:11 24:12 27:17 44:13

49:21 55:14 58:16,18 62:17 63:21

66:1 73:18 78:11 88:22 102:17

124:19 145:3,4 147:12 167:14

231:13 243:19 266:3,5 275:2 292:

22 293:11 299:19 301:12 303:7

stimulates [1] 60:13stimulatory [1] 60:11

stop [10] 40:21 41:14 64:2 131:1

179:1,5 213:10 220:7 295:16 296:

8

stopped [3] 30:4 32:4 76:7

stopping [7] 37:22 38:16 70:18

156:22 157:2 162:10 166:21

stops [1] 121:8

story [2] 116:14 247:10

STR [1] 74:11

straight [2] 4:15 33:12

straightforward [3] 126:20 157:

11 222:10

strain-specific[1]

251:7strand [1] 18:8

strata [8] 201:3 302:8,8,9,12,13,14,

16

strategies [6] 109:18 163:6 174:

15 257:7,16 282:21

strategize [1] 145:12

strategy [3] 145:14 153:7 206:11

stratification [6] 265:8 266:2,12

267:15 303:8 307:16

stratifications [1] 311:21

stratified [4] 76:1 213:2,6 237:15

stratify [3] 75:19 201:19 246:11

stratum [2] 265:8 268:3

stream [1] 57:1

street [2] 158:20 213:13stress [1] 261:1

strict [1] 41:12

strong [3] 78:15 232:21 301:17

strongly [9] 80:13 87:14 91:2 179:

14 187:16 188:12 196:22 229:2

244:12

structural [3] 18:19 55:10 61:1structure [1] 25:14

structure-function [1] 250:19

struggling [1] 219:18

stubborn [2] 183:21 184:12

Sheet 24 situation - stubborn



studied [17] 12:19 111:11,15 115:

8 137:22 157:21 169:14 197:11

206:2 211:16 220:9 225:18 242:1

264:21 277:17 281:1 311:8

studies [160] 12:20 23:4 27:9 32:

20 37:4 47:11 51:10 66:9,12 72:9,

17 73:7,14,15 92:12,17,19 94:5,12

96:8,9,10,10,11,13,16,17 97:5,16

103:10,12,16 105:17,18 114:14

128:9 131:21 133:11,17 134:13

137:8 141:20 153:4 157:4 158:5,7167:14 168:8,14,17 175:16 177:

16,21 178:18 187:19 194:10 195:

1 197:10,17 199:8 200:9 203:1,22

204:1,13 206:9,12 207:17,20 209:

17 213:6,7 216:1,3,18 217:20 218:

14 220:7,10,19 222:2,13,22 226:8

227:10,12 229:17 230:3,13 231:1

232:5 233:3,5,8 237:17 241:18

243:2 248:19 253:10,11,14 254:6,

15 256:9,11,17,17 257:19,20 260:

16 261:6,14,20,21 262:16 264:5,

22 267:18 268:9,10 270:10,19

272:5 273:4 274:3 277:2 278:6

281:14 283:7,14,16 284:11 285:1

289:16 291:15 295:16,21 296:12,15 297:3,4 299:1,3,13 301:18 302:

22,22 303:10,11 304:21 305:21

306:1,3,12 307:18,22 308:9,9,14,

14

studies= [1] 261:1

studies@ [1] 296:18

studiesB-I [1] 265:9study [109] 7:4 14:4 22:19 46:10

51:17 69:19 71:22 75:17 77:4 84:

20 88:7 98:9,15 100:1 101:20 105:

7,11,12 111:6 115:1 127:17,18,19

128:4 129:18,20 144:13 145:15

147:12 148:3,4 149:6,7,17 150:13,

14,18 152:2,6,8,12,21 154:13 167:9,18,22 180:11 187:7,17,21 188:6,

9,19 189:10 200:21 204:16,18

208:5,22 209:1,9 211:9,18,18 212:

7 213:2 214:5 215:6,15 216:2 217:

19 218:19 225:9,20 227:5 228:3,7

236:8 239:13,14 241:5,14 248:14

251:1 253:8 255:11 264:4,8,16

265:11 266:5 267:17 274:9 276:

15 278:2,15 280:22 291:16 293:2

294:22,22 295:2 296:3 305:4 307:

4 308:16 310:7,10 311:19

studying [2] 140:14 205:2

stuff [1] 34:8

sub-specialists [1] 289:20

subcutaneously [1] 291:11subgroup [7] 81:3 193:19 259:12,

20 289:7 294:15 295:14

subgroups [17] 11:18 13:18 23:4

197:2 246:13 269:19 284:7,20

288:17,19,20 289:4 294:8,11,13

295:13 308:1

subject [6] 14:15 55:21 77:15 94:4

157:10 228:8

subjecting [1] 240:21

subjects [3] 13:10 16:22 272:12

submit [3] 191:10 217:18 218:21

submitted [1] 107:14

submitting [1] 8:5

suboptimal [1] 179:8subpopulation [1] 72:21

subpopulations [4] 87:20 88:9

263:19 298:1

subsequent [1] 144:17

subsequently [3] 152:21 168:20

170:21

subset [4] 45:6 72:9 179:3 227:9

substance[2]

99:3,4substantial [2] 138:15 304:20

substantiated [1] 129:11

substitutes [2] 79:14 81:4

substituting [3] 132:10 254:1 255:

9

substitution [7] 14:20 132:4 140:

18 253:10,14 256:16 257:7

substitutions [1] 275:18

substudies [3] 193:6 195:16 270:

19

substudy [1] 213:8

subtract [2] 253:5,6

subtype [1] 20:13

subvert [1] 61:3

succeed [1] 217:8success [5] 83:10,12 119:6 125:

13 262:5

successful [4] 141:2 229:19 279:

20 282:21

successfully [1] 312:16

sudden [1] 308:16

sufficient [9] 65:22 137:20 213:9

269:12 303:21 305:2,14 308:19,

20

suggest [11] 22:13 27:10 83:11 97:

5,7 103:11 104:7 105:7 129:13

144:13 269:9

suggested [14] 43:11 97:13 114:

13 123:6,12 125:10 132:21 141:22 156:17 170:3 226:4 236:5 238:

16 262:14

suggesting [11] 22:17 36:13 37:2

49:13 221:1 241:6 265:12 269:11

270:2,18 293:22

suggestion [1] 192:16

suggestions [2] 40:6 130:7

suggests [5] 18:9 19:5 58:21 133:

19 245:5

sum [3] 257:9 301:16 302:6

summarize [5] 13:2 15:18 108:5

197:6 232:7

summarized [1] 275:1

summarizing [1] 51:8

Summary [5] 3:23 106:7,14 108:1181:3

summation [1] 268:7

Sun [7] 2:10 5:22,22 8:14,19 218:5,

6

Sun=s [2] 8:16 246:2

superb [1] 228:10

superior [1] 262:6

superiority [4] 79:6 238:8 252:5

257:8

support [7] 88:17 129:16 135:9

179:14 207:17 226:17 249:10

supportable [1] 253:7

supported [1] 129:11

supportive [1] 270:16

supportiveB-very [1] 270:16

suppose [4] 159:7 163:2 209:12

210:9

suppresion [1] 125:12

suppress [3] 124:17,18 161:12

suppressed [1] 162:11

suppresses [1] 272:2

suppression[10]

120:11 124:16137:7 140:5,6 141:20 150:12 162:

14 175:12 196:5

surely [1] 283:15

surprised [1] 312:9

surprising [1] 183:17

surrogate [4] 53:19 61:15 120:7

121:3

surrogate-Bit [1] 53:18

surrogately [1] 70:4

surrounded [1] 47:5

surrounding [2] 186:7 190:11

survey [1] 154:15

survival [6] 72:21 80:2 126:12 146:4,6 153:21

survive [1] 188:7suspect [5] 151:9 159:10 169:3

199:21 302:2

suspected [1] 36:20

sustained [18] 37:16 51:12 58:19

63:11 64:3 101:6 117:19 120:18

160:1,2,9 161:11,14,15 175:15,18

227:8 238:18

SVR [70] 11:15 39:13 62:5 64:6,18

65:22 69:2,3 70:15 71:5,19 73:19

77:20,22 80:3 101:21 104:2 118:1

120:10,18 121:2,10,16,17,21 122:

1,5,10,14,20,21 123:2,14,16,21

127:16,21 128:1,4,5,8,12 135:15,

17 136:20 137:2 139:11,11,11141:9,13,17 143:22 144:20 147:1

156:21 158:12,13 159:10,11 160:

12 161:19 165:11,13,15,18 184:4

195:11 253:3 279:9

SVR12 [1] 15:6

SVRs [2] 64:15 143:1

swallow [1] 291:8

Swan [20] 2:17 5:4,4 197:15,16

211:13 212:2 234:10 240:9,10

259:5 260:14,15 266:6,7 271:10,

11 305:9,17 312:7

swinging [1] 163:7

switch [1] 163:10

switching [1] 56:8

sympathetic [1] 217:15symptoms [2] 25:21 48:2

synergistic [1] 132:19

synthesis [1] 62:11

synthesize [1] 105:3

synthetic [3] 79:22 110:21 204:20

syphilis [1] 82:22

system [7] 4:9 60:6,7 176:11 183:

1 227:16 228:21

systems [2] 67:2 128:13

TT-alpha-1 [1] 56:7

T-alpha-2 [1] 56:8

T-cell [1] 181:20T-helper [3] 55:12,20 56:2

T-helper-1 [4] 56:11 60:8,16 62:

22

T-helper-2 [1] 63:2

T-lymphocyte [1] 57:7

T-regulatory [1] 56:4

t.i.d [1] 266:20

table [3] 8:3 84:6 310:22

take-Beven[1]

249:14takeB-if [1] 231:9

Talal [1] 42:5talked [8] 66:5 68:21 175:7 177:13

178:1 235:16 241:7 274:1

talks [2] 88:13 190:20

target [8] 25:11 55:5 225:20 282:2,

19 283:1 303:15 311:17

targeted [4] 213:8 250:21 257:12

263:2

targeting [1] 184:9

targets [3] 19:1 250:20 276:16

targetsB-to [1] 196:7

task [4] 90:8 92:16 106:10 196:10

tAttAt [1] 85:12

tattooing [1] 24:19tau-like [1] 12:10

Tauber [17] 2:24 3:24 6:5,5 13:2

15:17 106:9 144:1 145:19 150:11

154:9,14 155:5,16 156:15 178:10

198:22

Tauber=s [1] 181:3

teams [1] 180:13

technique [2] 67:17,20

techniques [1] 145:1

technology [4] 117:9 120:8 123:9

135:18

teeth [1] 226:10

tempered [1] 205:19

temporary[1]

277:13temptation [1] 78:6

ten [4] 85:18 101:9 141:12 172:1

ten-fold [1] 54:2

tend [5] 98:21 175:21 176:12 187:

13 286:13

tendency [1] 267:6

tends [2] 21:19 187:8

tenofovir [2] 272:10,17

term [4] 80:3 163:1 222:2 293:15

terminate [4] 68:5 161:10,13,19

terminated [1] 167:22

terminates [1] 63:19

terminating [1] 51:1

termination [6] 58:5 59:15 79:18

154:6 162:15 170:16terminology [1] 28:12

terms [45] 17:8,9 23:21 40:10 41:

12,20 46:6 48:12,17 64:13 66:2

73:19 79:14 86:16 96:17 97:14 99:

11,14,17,17 104:1,5 112:2 139:4

143:13,22 144:13 145:15 156:10

162:4 166:17 168:22 191:19 194:

4 228:5 251:19 252:1 253:2,3,15

267:8,16 275:3 279:12 308:18

terrible [2] 231:4 288:21

terribly [3] 55:1 220:22 241:15

Sheet 25 studied - terribly



terrific [2] 231:8,18

test [6] 25:6 41:22 54:8 70:11 132:

19 181:19

tested [3] 38:12 44:12 151:22

testing [5] 24:14 26:4 163:15 193:

1 247:3

tests [8] 24:22 25:2,6 26:6 54:7

101:15,19,22

Texas [1] 16:15

text [1] 86:18

Th1[1]

56:21Thanks [2] 83:22 261:16

that=s [1] 37:7

theme [1] 122:9

themes [1] 118:17

themselves [3] 58:12 100:11 287:

7

theoretically [1] 33:9

theory [1] 63:22

Therapeutic [8] 3:15 50:13,19 51:

18 55:21 181:12 182:18 278:11

therapeutically [1] 56:19

therapies [28] 40:3 69:16 70:20

77:13 82:20 150:8 175:9,14 178:4

180:21 181:2,10 182:21 183:6,7

184:6,21 185:1,9,10 186:8 207:7,13 209:14 214:17 217:19 254:3

266:11

therapy [102] 14:2,2 29:4 34:18 37:

3 39:12,14 51:13 57:1 58:2 63:9,

20 64:2,5,16 65:3,4,13,20 68:10,

17,17 70:5,10,11,18 71:9 73:3,6

76:8 79:1 81:22 82:19 83:5 93:17

98:17 100:15 102:18 109:11,12

116:8 143:13 145:2 151:1 153:14,

17 159:10,13,14 160:2,9 161:2,10

166:14,16,16 168:18,22 169:15

170:22 176:9,17 177:11 179:6,8

180:8 182:14 183:12 186:1 192:1,

20 196:1,9 205:3 208:3 212:4 213:16 214:11 217:9 235:7 238:17

240:3 252:22 253:18 259:11,13,

15,17,18,20 260:2,7 262:6 267:21

275:9,11,14 276:16 279:20 280:

10 282:5,18

thereafter [1] 228:6

thereby [2] 184:13 242:6

Therefore [17] 35:12 53:6 61:15

133:10 138:2 146:9 188:8 189:6

199:5 207:7 215:13 217:19 219:2

265:20 279:17 289:18 306:20

thinking [7] 92:10 214:3 215:5

253:13,15 258:22 307:2

third [7] 26:7 32:19 130:2 132:1

140:14 199:3 279:14this-Bthat [1] 146:3

thisB-12-week [1] 40:1

though [14] 11:16 25:2 26:5 103:

13 125:14 150:17,21 157:15 160:

16 233:6 257:18 268:22 276:22

302:2

thoughtful [2] 233:17 259:8thoughts [4] 81:18 211:21 222:17

235:10

Thousands [1] 215:9

three [34] 9:20 10:19 13:11 54:17

65:21 66:14 75:20 76:12 85:1,20

86:1,4 101:6 103:2 104:1 125:3

130:19,22 136:13 141:14 160:10

167:4,6 175:22 236:3 237:19 241:

12 292:11,11 303:20,22 304:1

305:4 307:16

threshold [1] 129:9

threw [1] 164:22

through-BI [1] 301:21throughout [1] 202:7

throw[3]

158:10 227:4 272:14Thursday [1] 1:7

tied [1] 39:2

tight [1] 41:20

till [3] 88:20 154:13 270:13timely [3] 96:14 205:17 300:10

timing [4] 15:6 68:2 121:17 139:14

tired [1] 176:3

tissue [2] 63:1 67:19

tissues [2] 18:14 52:12

title [2] 106:13,15

to.@ [1] 270:15

today [29] 12:1,6,14 15:19,21 17:2

47:13 84:1,4,5 85:22 89:14 90:5

92:11,18 95:6 97:17 99:3,8 106:

22 107:3,6 180:18 181:5 187:7188:18 195:19 257:1 309:4

today=s [5] 7:8,21 8:3 9:16 15:11

together [4] 35:21 105:10 112:16

241:13

tolerability [6] 81:16 251:14,18,19

252:1,7

tolerance [2] 175:5 275:13

tolerate [2] 70:21 150:20

tolerated [5] 73:22 119:2 174:22

290:17,22

tolerating [1] 290:18

Tom [1] 297:8

tomorrow [3] 15:21 312:4,22

tomorrow=s[1]

15:11tonight [1] 237:21

took [3] 128:8 224:19 239:2

tool [2] 67:8 182:18tools [5] 44:9 123:22 139:19,20

140:1

top [5] 75:6 76:15 110:12 207:22

261:4

topic [6] 7:8,12 9:16 10:13 173:1

294:12

topics [1] 7:13

total [6] 24:13 31:7 120:10 172:6

237:12 283:4

totally [1] 162:21

touched [2] 98:10 112:18

tough [1] 251:17tougher [1] 73:16

toward [1] 81:12

towards [5] 42:8 153:21 199:16

264:9 267:6

toxicities [6] 81:2 222:3,6 223:17

224:18 293:11

toxicity [16] 11:19 94:19,20 131:15

132:18 176:18 189:12,16 206:8

210:11 241:8,8,9,11 263:21 265:1

Tracey [1] 2:17

track [7] 85:13 91:3 93:9,13 100:5

104:6 228:11

tract [1] 67:19

tracts [1] 67:13

Tracy [14] 5:4 197:15 199:21 211:

12 234:9 240:9 260:14 261:19

262:14 266:6 271:10 305:9,16

312:5

tradeoff [1] 218:17

tradeoffs [1] 218:15

traditional [1] 159:11

traditionally[1]

222:22traffic [2] 86:11,15

trajectory [2] 218:3 280:5

transiently [1] 26:10

translate [3] 136:3 165:5 279:15

transparency [1] 172:14

transparent [1] 172:12

transplant [71] 21:12 45:17 71:15

74:4 80:11 88:12 93:5 109:4 115:

9 126:16,22 127:6 128:3,22 129:2

136:16 146:1,10 150:20 152:19

160:19,22 195:5 210:6,8 216:21

217:6,17 218:1 219:21 220:19

221:11,17,18 225:6 228:19 258:

10 273:10 274:4,4,7,7,13,14,16,20

275:9,11,21 276:5,8,13,17,19 277:19 278:9 279:10,14,18 280:13,14,

21 281:9,11,21 282:8 284:6,10,11,

19 296:3

transplant-free [1] 80:2

transplantation [23] 6:4 11:1 13:

13 76:17 78:21 111:22 126:11,19

127:2 128:18 146:6 152:9,16 204:

3,7 222:19 225:7 228:21 273:6,10,

16,19 280:9

transplanted [5] 74:12 127:4 146:

5 204:15 274:22

transplanters [1] 129:3

transplants [5] 74:14 213:20,22

217:2 231:22travel [1] 173:3traveled [1] 87:2

Treat [27] 3:15 39:6,6 50:13 73:16

83:7 111:20 112:13,16 130:22

134:2 143:14,14 145:10 157:18

174:14,17 220:22 222:11 242:5

249:18 262:10 283:8,19 295:7

296:10 298:16

treated [34] 26:22 34:14 36:5 41:

13 64:9 115:20 148:1,7,11,12 153:

19 178:15,21,22 199:13,22 200:6

201:17 203:13 212:22 220:16 221:

1 223:12 231:7 237:8 239:21 240:

8 259:14 268:21 269:8 287:17,18

292:17 295:1treating [10] 47:14 76:14 81:19

140:17 151:2 192:12 220:18 243:

1 274:1 278:9

Treatment [125] 3:22 5:4 6:22 14:

4 23:16 39:4,9 40:3,20 43:14 44:

17 49:12,13 63:15 64:22 65:8 73:

17 76:9 77:21 78:14 82:2,22 83:

18 86:22 88:19 100:7 106:19 109:

7,17 113:14 114:16 117:11 118:6,

14 119:9,20 121:4,8 122:15 124:3

131:1,13 134:9,11,18 136:10 137:

3,10 139:6,7,8 140:15,16,18 141:

10,18 144:21 148:12,16 149:9,12,

13 152:14 153:11 155:9,10,20

158:6 160:22 161:14 162:7 165:5

166:21 168:4 169:4 174:6,9 175:

18 182:2,7 183:10,18 184:3,16

191:14,14,20 193:1,3 194:3 196:

14 200:11,22 201:18 207:11 210:

20 232:17 233:5,22 234:2 235:9

236:1 240:16 242:20 243:13 255:

3 259:3 262:4 263:15 264:5 267:9268:4,15 272:12 273:15 279:18

280:14 287:11,20 292:6 293:1,6,8

297:10 303:13

treatment-experience [1] 233:

10

treatment-experienced [23] 14:

15 75:6 76:4 78:2 111:13 113:17

119:1,8 123:1,4,15,19 138:4 177:

9 178:2 179:21 234:3,7 236:16

241:15 244:5,17 280:20

treatment-expreienced [1] 130:

8

treatment-naive [14] 74:21 75:16

111:14 113:9 119:5 122:22 123:5,

18 125:17 130:4 138:1 177:8 269:6 270:18

treatment-race [1] 303:5

treatmentB [1] 294:20

treatments [18] 113:1 117:17 122:

11,13 131:6 135:3,16 138:17 139:

13 151:3 153:1 184:14,18 232:16

244:9 249:11 261:10 272:10

tree [3] 19:19,22 166:12

trees [1] 19:20

tremendous [2] 92:16 185:3

trespass [1] 154:20

tri-infected [1] 187:1

Trial [67] 3:14 6:20 12:18,21 14:7,

10 15:15 41:3,14 50:9,12 51:2070:17 77:16,18,21 78:6 106:18

139:1 147:13,13,15 149:9 152:7,

13 167:1 176:11 185:14 186:14

192:19 211:16 220:21 221:21 223:

15 224:6,8,10,21 225:3,11 237:6

250:4 253:19 254:7,18 259:19,20

260:8 262:2,3 263:4 267:20 268:5

269:6 278:11 281:4 282:19 289:

19 291:17 292:7 297:17 302:13

309:8 310:8,14,18 311:4

trials [63] 11:14 13:1 39:17 40:14

51:14,17,19 60:2 64:14 65:16 73:

20 77:12 79:6 80:16 81:12 114:8,

13 135:3 138:12 146:21 157:16

167:4,6 174:5 179:15 185:11 186:17 191:4 192:15 194:13 212:10

218:13 222:8 227:7,9 232:14,20,

22 241:1 243:5,16,20 244:12 259:

9 261:22 262:12 268:19,19 270:

12 271:13 277:4 281:20 287:21

288:13,14 291:13 298:5 300:13

309:2,3,13 310:12 312:16

tricky [1] 294:12

tried [1] 189:14

triglycerides [1] 104:13

trillion [2] 19:6,7

Sheet 26 terrific - trillion



trim [2] 67:21,22

triphosphate [1] 62:12

triply [1] 272:16

trough [3] 277:8,22 301:4

true [18] 43:15,18,18 62:19 63:3 69:

20 71:14 116:19 117:21 160:15

165:5 200:11 235:3 239:12,20

272:19 285:20 300:6

truly [5] 54:21 65:5 81:18 167:18

280:4

try[17]

76:10 84:4 95:2,13 97:3103:20 105:17 124:1 168:9 192:

16 197:6 219:11,15,16 272:11

282:8 301:20

trying [12] 121:13 145:10 152:13

163:21 224:12 243:11 248:21,22

255:4 270:4 294:5 295:22

tumors [1] 184:10

Turcotte [3] 128:16 129:1,7

turn [7] 4:8,11 63:9 74:17 129:20

196:19 277:22

turned [1] 23:17

turnover [2] 82:3 135:4

turns [1] 285:8

twelve [1] 171:4

Twenty-four [1] 64:4twice [2] 137:5 141:18

two [49] 13:11 14:21 19:10 35:4,7

37:11 51:22 56:6 81:10,12 85:11

87:15 88:16 90:18,21 94:19 101:5

113:7 116:2 119:14,17 133:6 140:

20 144:15 155:10 158:12 159:18

166:3 168:4,5,11 171:19 174:19

175:16 186:10 201:2 240:20 251:

22 266:3 273:22 278:21 290:12

291:14 292:10,11 301:5 303:19

304:1 310:8

two-day [1] 227:2

two-fold [1] 162:2

two-log[2]

40:17 70:9two-part [1] 106:15

two-plus [1] 133:21

two-thirds [2] 18:2 255:22

type [15] 32:22 35:14 36:3 70:1

125:21 166:12 169:15 182:16,17

208:4 214:21 218:16 248:9 271:5

295:17

types [11] 56:6 62:14 151:14,16

169:1 181:2 182:3 185:13,15 309:

19,20

typical [2] 25:18 27:8typically [2] 119:13 160:18

U

U.S [10] 10:16 18:3 21:8,12 22:1975:22 245:11,18 303:20 304:22

ultimate [6] 50:19 59:15 82:6 176:

16,18 224:14

ultimately [8] 30:10 56:19 80:1 83:

13 93:15 170:16 247:13,18

unable [2] 195:22 196:8

unaddressed [1] 17:11

unanimous [1] 311:16

unapproved [1] 295:3

unavoidable [1] 217:7

unbalanced [1] 228:18

unboosted [1] 301:3

unclear [2] 32:12 142:13

uncommon [1] 19:7

Unconfirmed [1] 24:16

unconscionable [1] 201:7

under [17] 14:4 63:20 65:3,13 116:

6 144:3 189:22 210:8 211:19 212:

7 270:11 286:3 287:21 288:13

291:16,17 292:10

under-represented [1] 114:11

undergo [3] 23:16 24:6 45:17

underlie[1]

58:1underlying [1] 76:21

underscore [2] 216:19 246:7

understand [31] 94:17 96:3 102:5,

10,12 109:16 113:14 114:15 156:

12 164:4,9 172:16 176:19 179:5

185:12 189:13,15 192:3 193:9

195:8 215:4 218:2,10 220:21 222:

12 224:17 227:19 229:4 242:9

303:11 311:6

understandably [1] 219:3

understanding [10] 45:7 62:17

114:9 192:7 251:5 264:18 266:7

267:11 293:12 300:4

understands [1] 94:9

understood [6] 27:18 68:14 132:7220:6 286:18 293:21

undetectability [1] 71:22

undetectable [4] 120:20 127:5

165:19 238:17

undetectableB-again [1] 123:8

undiagnosed [1] 22:10

unduly [1] 230:15

unequal [1] 113:7unequivocal [1] 217:3unequivocally [1] 146:2

unforeseen [1] 204:6

unfortunate [1] 186:22

unfortunately [4] 60:17 64:18

150:17 275:22uniform [2] 139:18 155:8

uninfected [3] 27:19 28:2 30:13

unintended [1] 181:9

unique [1] 300:5

uniqueness [1] 281:4

unit [3] 43:1 47:5 286:11

United [11] 17:16,22 20:17 22:8 74:

14 79:2 97:20 113:12 245:18 280:

9 304:1

University [6] 3:19 4:21 5:12 16:

14 190:17 191:2

unknown [2] 141:13 167:14

unless [4] 132:11 197:20 284:4

289:18

Unlike [2] 7:6 36:20unlikely [2] 39:12 40:19

unmet [3] 179:22 184:2,13

unnecessary [1] 261:6

UNOS [1] 79:4

unproven [2] 52:12 136:4

unpublished [1] 146:21

unrealistic [1] 263:5

unreasonable [1] 256:6

until [15] 30:10 38:3 95:17 103:14

115:1 151:22 232:20 239:3 256:

15 272:22 283:12,14,19 296:15

297:12

untilB-and [1] 104:19

untreated [2] 112:15 120:22

unusual [1] 98:20up [70] 4:14 9:22 10:20 12:2 17:1,3,

19 19:7 26:12 27:3 32:16 34:1 35:

19 49:1 53:5 82:15 88:20 96:21

104:9 105:19 110:5 118:19 119:3

125:9 132:21 133:13 136:14 141:

14 142:8 147:10 152:18 157:20

164:22 165:15 171:7,20 172:4173:17,18 176:8 186:6,11 199:10

200:13 201:1 203:7 206:12 212:1

213:1 214:10 215:15 220:4 221:6

226:19 228:16 229:12 245:8 248:

18 256:4 257:9 266:2 276:1 283:5,

22 297:8 299:1 301:16 302:6 303:

4 304:15

up-front [1] 262:14

up@ [1] 224:5

upcoming [1] 26:21

update [1] 167:3

updated [3] 11:7 15:13 22:3

updating [1] 21:15

upper [7] 53:12,12 63:4 110:5 304:

3 309:10,22upwards [1] 247:11

urban [1] 97:21

urge [1] 80:13

urgency [4] 73:10 228:19 266:11

300:7

urgent [2] 113:20 261:11

urging [1] 296:11

usage [2] 102:6 288:1

useful [6] 24:15 44:11 130:13 140:3 207:9 285:17

usefulness [1] 229:6

users [4] 99:2,3 312:10,16

uses [1] 37:22

using[28]

37:9 40:7 63:12 65:18118:15 120:6 123:8 130:8,13,20

133:6 144:22 147:1 155:20 158:

15 160:12 164:21 166:5 185:11

192:22 223:3 255:12 263:16 283:

18 290:12 291:10 299:14 312:15

usual [1] 152:17usurp [2] 52:4 74:19

utility [4] 66:18 93:18 101:16 182:

19

utility-Bnot [1] 101:15

utilization [4] 67:9 77:8 79:15 276:

19

utilize [1] 181:10

utilizing [1] 138:17

VVA [1] 5:7

vaccine [1] 50:21

vaccines [3] 181:12 186:4 251:8

valid [5] 136:2 146:10 176:5 245:

16 246:1

validate [1] 136:11

validated [5] 79:20 139:13,22 240:

18 261:15

validity [1] 122:15

Valley [1] 20:19

valuable [1] 211:22

value [5] 40:16 121:14 123:18 129:

12 185:13

values [1] 129:9

vantage [1] 206:14

variabilities [1] 41:16

variability [7] 27:3 41:18,21 44:14

53:16 69:1,14

variable [6] 43:21 45:21 52:21 53:

5,6 83:1

variation [1] 27:1

variations[1]

281:17variceal [2] 110:20 167:9varices [1] 45:14

variety [11] 25:10 52:9 61:2 78:4

79:5 205:13 214:7 216:22 245:20

277:2 298:22

various [8] 21:1 32:9 45:10 76:5

165:3 181:14 184:8 290:1

variously [1] 120:19

vary [1] 162:4

varying [2] 20:16 33:5

veering [1] 229:21

venous [1] 167:8

venture [1] 119:20

versus [13] 14:2 36:18 42:1 69:6

71:20 74:12 111:7,14 201:1 215:20 235:17 246:17 259:15

vertex [2] 91:16,20

vertical [1] 287:1vertically [1] 290:5

viable [5] 163:6 179:12 244:8 251:

15 255:20

vice [1] 174:1

Videx [1] 261:3

Vierling [39] 2:20 3:16 6:2,2 7:20

15:15 37:12 50:7,15 83:15 84:7

99:14 129:10 143:17,20 153:2,3

161:6,7 167:2 170:6,7 203:14,15

216:16,17 220:17 223:20,21 227:

22 228:2 246:6,7 254:15,20 273:22 277:5 278:8,20

Vierling=s [3] 112:21 116:16 180:

21

view [9] 52:3 177:15 201:8,22 221:

12 250:3 253:14,20 306:7

viewB-I [1] 306:22

viewed [1] 280:22

viewing [1] 242:10

viewpoints [1] 119:15

views [1] 198:17

vigorous [1] 55:13

Viral [99] 3:12 15:13 16:3,22 18:1627:1,2,8,11,15 28:9,12,15,19,21

29:1,5 30:5,10,21 31:18 32:22 33:

4,10,20 34:21 37:5,16 39:18,2140:5,7,11 41:9,19 42:16 43:14,20

55:15 56:1 57:16 62:14 63:13 69:

4,6,17 71:21 90:3 113:10 118:18

120:4,11 121:3 122:21 124:9,16

125:11 127:4 130:11 134:21 135:

22 140:5,6,11 144:1 153:5 158:15

162:11,22 165:9,14 166:22 169:2,

20 170:1 175:8 180:11,19,22 181:

14 183:5,10,22 184:12,21 200:2,

21 220:15 239:22 240:5 243:3

253:2 267:6,12 282:13 285:1 307:

Sheet 27 trim - Viral



21 310:14,18

virally [1] 56:12

viremia [7] 54:6 127:1 128:2 144:

22 160:21 161:3 279:10

viremic [1] 279:16

virions [3] 19:6 29:15 162:1

virologic [26] 15:5 51:12 58:19 63:

11,17,17 64:3 65:4,7,18 70:8,10,

12 72:3 75:11 117:20 120:18 123:

17 161:11,15 166:14 192:1,5 193:

4 196:4 236:7virological [1] 82:7virology [1] 292:17

virtually [4] 35:8 225:7 278:9 303:

18

virtue [1] 132:17

virus [63] 18:5,7,8,22 19:4,10,14

20:20 23:18 27:16,16 28:4,6 29:

13 31:7 32:5 33:18,22 34:7 35:9

37:14 39:11 40:20 44:2,2,3,4 52:9,

16 55:11,17 57:14 61:3,5 63:20

69:5 82:4,6 84:21 133:2 144:2,8,

10 145:1 147:2 149:13 158:19

160:7 163:15 165:17 175:15 183:

15,16,20 188:1 237:13 242:18

272:1 282:11 287:1 293:13,17297:21

virus-specific [1] 282:17

virusB-you [1] 124:18

viruses [2] 46:13 231:7

visible [2] 17:10 160:20

vitro [2] 176:10 184:9

voice [3] 107:7 119:14 124:5

voices [1] 107:8

VOLUME [2] 1:6 86:11

vote [1] 226:17

Voting [1] 2:13

VX950 [2] 94:16 103:3

Wwait [5] 64:11 205:8 232:20 249:22

270:12

waiting [17] 79:4 153:12,16 154:

13 214:12 215:8 216:21 217:12

219:20 221:11 222:19 223:8 228:

13,14,17 231:22 276:4

Waiver [1] 7:22

waivers [2] 7:17 8:4

walking [1] 213:12

wall [1] 109:21wanes [1] 286:20

wanted [10] 66:12 115:1 126:2

141:2 158:2 190:22 193:21 218:6

284:14 312:6

wants [2] 172:2 243:15warrants [1] 200:11

wasB-and [1] 137:4

Washburn [5] 2:12 5:6,6 9:21 10:

6

Washington [2] 4:21,22

washout [1] 158:21

wasn=t [7] 131:19 157:11,20 160:

9 253:13 254:12 305:11

waterfront [1] 267:1

way [52] 10:18 29:11 33:16 52:4 85:

15 90:8 95:10 13 106:17 109:19

164:8 168:12 179:3 180:5 181:1

192:13 193:18 198:1 202:10 204:

17 205:2 211:19 212:7,10 214:4

220:3 224:13 229:3,9 250:20 251:

3 254:5 255:9 265:3 270:11 271:

20 277:18 287:21 288:14 289:8

291:16,17 298:5 302:18 308:11

311:20

ways [9] 47:7 60:13 61:3 99:1 130:

19 155:1 234:1 271:12 310:4

weak[2]

182:11,15web [2] 8:1,2

website [3] 86:9,12,15

week [7] 32:16 42:9 116:2 163:17

164:6 166:3,7

week=s [1] 164:5

weekly [1] 193:2

weeks [62] 26:7,9 37:19,19 39:11

40:18 41:5 58:20,21 64:4 65:10,

11,19 70:9,11,13 72:1,1 85:10 91:

19 99:21,22 100:7 109:9,10 116:3,

7 118:10,16 119:14,17 120:21

121:4,9,20 122:2 123:11 132:21

133:1 139:15,16 143:2 155:11,11,

13 156:19,19,21 157:19,22 159:12

161:3 166:3,22 168:17,18 192:13252:13,13,22 263:7 264:6

Weight [3] 69:7,21 164:1

weight-based [1] 71:3

welcome [1] 106:9

well-characterized [1] 193:15

weren=t [2] 104:19 254:16

whatever [14] 29:20 31:9 84:21

129:2 146:22 191:20 198:15 205:

15 220:2 221:2 250:1 256:19 269:

8 276:18

wheels [1] 193:11

whereas [1] 119:7

Whereupon [2] 171:11 313:1

wherever[1]

139:5whether [43] 13:7,8,15,21 14:9 32:

11 36:21 40:3 62:15 80:4 124:13

136:2 139:20 143:5 150:3 153:5

160:10 161:10 162:13 168:9 191:

20 197:10 201:20 203:4 205:3

216:1 218:2 224:2 244:6 246:19

247:13 265:9,14 267:15 274:6

279:10 282:16 284:15 296:14 297:

13 299:20 304:12 305:22

whichever [1] 295:15

white [4] 47:3 88:15 89:3 309:10

whites [9] 75:18 201:1,9 304:3,14

306:9,9 307:3 310:19

whoever [1] 207:8

whole [11] 38:2 50:4 59:13 77:4157:9 205:7 227:2,14 231:11 299:

1 309:11

whom [8] 134:18 141:19 222:19

235:22 264:20 279:7 297:19 306:

19

widely [1] 148:6

will [179] 4:17 6:11 9:2,9,10,18 10:1,11 11:5,6 13:2 15:12,14,16,17,

18,20 16:22 17:3,6 19:1 21:2 25:3

28:4,6 37:12 39:22 48:5 49:19 50:

16 64:12 66:9,13 68:9,17 77:7 78:

13 83:10,12,12,16,19 84:4,8 89:7,

9,11 90:1,11,20 93:17,19 99:12

101:3,6 102:5,6 106:3 107:19 108:

4 109:9,10 117:6,7,18 120:3 121:

22 126:7 127:3 133:2 136:3 138:

11 139:21,22 140:1 142:10 149:

17,18 151:14,21 152:18,20 153:4

154:5,6 157:8 158:16 160:18 168:

1,2,5,10 170:20 171:4,6,8,10,20

172:4,7 173:10,14 175:2 176:4177:15,19 178:7 181:13 183:5,15

184:4,11,11 185:10 186:2,4,11

191:9 193:10 197:6,16 204:9 205:

8,10,12,14,16 206:1 208:9,18 210:

15 213:10 217:8 219:11 220:3

226:19 228:15,15 229:6 234:22

237:21,22 238:2 245:3 247:13

249:21 251:4 255:15 256:18,20

257:19 258:1,12 262:18 264:20

269:15 272:4,13 278:15 280:6,10

283:13 285:15 288:1 291:3 296:4

299:14 302:1,2,6 312:4,21

William [2] 2:24 3:24

willing [3] 175:2,12 298:16

window [2] 37:18,21Wisconsin [1] 5:2

wish [4] 9:6 52:1 172:8 208:8

withB-if [1] 230:21

Within [32] 19:11 22:22 27:4 32:16

40:11 45:6 59:6,20 61:5,11 62:20

63:1,13 64:12 65:10 67:1 73:20

74:7 85:10 121:19 162:10 234:11

257:14 262:8,10 271:18 274:18,

19 284:7 292:2 302:12 308:12

without [27] 57:1 81:6 93:6 100:22

126:10 129:16 131:22 148:20 149:

10 160:6 161:1 168:4 182:2,7 208:

21 212:11,13 217:12 240:10 247:

5 265:19,21 279:10 297:4 298:12304:21 306:4

woefully [1] 275:2

women [7] 38:19 45:3 46:11,12

188:14 201:14 308:19

won=t [4] 101:1 207:9 288:19 300:

10

wonder [2] 159:19 160:9

wondering [3] 85:21 211:17 300:

16

word [2] 84:22 307:17

words [18] 30:5 44:19 65:1 114:1

118:10,15 131:12 132:1 149:1

151:15 164:15 165:14 176:22 215:

17 224:5 249:7 252:16 305:4

work [27] 22:16 34:8,12 42:5 73:2292:1,2 132:7 164:20 189:19,21

190:12 194:19 200:1,20 227:19

229:16 245:9 256:15 262:14 269:

18 284:2 290:19 303:13 309:14,

15,17

worked [8] 85:5,7,12 165:1 191:4

242:3 263:8 310:5

worker [1] 26:3

workers [2] 24:8,9

working [7] 49:22 59:12 85:2 125:

works [10] 130:17 200:1 231:5 232:

4 245:10 254:6 297:11,15,18 303:

14

world [15] 17:9 20:15 28:20 29:1

42:18,20 43:2 89:7,11 188:4 202:

7 236:1 245:17 247:19 277:1

worldwide [2] 11:1 21:7

worms [1] 252:2

worried [1] 283:9

worries [1] 301:10

worry[1]

231:12worsening [2] 127:14 150:13

worst [2] 217:18 276:6

worth [6] 159:7 164:5 210:9 230:6

235:13 255:11

worthy [2] 170:5 243:12

wouldn=t [9] 64:19 154:19 157:7

204:13 211:10 212:4 245:9 266:

22 271:7

wrist [1] 240:2

write [1] 138:9

writing [1] 173:14

written [3] 8:5 132:10 172:20

wsd [1] 310:18

Xxenograft [1] 184:9

Yyear [24] 10:18,21 22:14,17 23:15

45:7 48:4,5 54:15,18 74:7 86:14

106:17 136:8 137:6 141:18 146:4

149:18 168:1 215:7 228:14 252:

21 281:10 292:2

year,@ [1] 250:1

year-Bwell [1] 252:21years [68] 10:4 17:18 20:22 25:17

26:20 27:7 39:10 46:1,14 49:1 50:

1 54:3 55:3 57:2 64:9 73:6 74:5

84:13,13,15 85:1,18,21 86:1 87:2,

8,11 89:1 100:15 101:7,9 103:2,9104:1,5,9,15 105:8 136:1,13 137:

11 141:12,14 142:1 148:4 149:9

160:10 168:4,6,11 175:17,22,22

176:2 187:2,2,3 241:11 274:18,19

286:4,13,19 288:1,7 289:5 296:4

297:5

years-Band [1] 39:22

yellow [2] 69:2 71:6

York [6] 5:5,16 86:7 87:10 89:20

98:4

young [3] 45:2 46:12 291:5

younger [1] 292:8

yourself [2] 16:7 165:15

Zzero [5] 29:15,17 30:6 31:19,20

zone [1] 292:12

Documents

US Food and Drug Administration: 2006-4250T1-Index