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1. Regulating blood volume and pressure
2. Regulating plasma concentrations of sodium,potassium, chloride and other ions
3. Stabilising blood pH
4. Conserving nutrients
5. Detoxifying poisons (with the liver)
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Kidneys
Ureters
Urinary bladder Urethra
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CT abdomen with contrast MRI coronal abdomen
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3 layers of connectivetissue:
Inner layer- Renal capsule
Middle layer- Adiposecapsule
Outer layer-Renal fascia
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Renal cortex
Retroperitoneal space
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Hilum is located onthe medial surface
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10 cm
5.5cm
3cm
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Renal pyramids
Renal papilla
Renal Columns
Renal Lobe
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1. Proximal convoluted
tubule
2. Descending loop of
Henle
3. Ascending loop ofHenle
4. Distal convoluted
tubule
5. Collecting duct
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Blood enters the kidney
through the renal artery at
the site of the hilum
The renal artery divides in
to ever smaller arteries and
arterioles
Afferent arterioles take blood to
the glomerulus to be filtered
Once blood is filtered
efferent arterioles take blood
away from the glomerulus
The glomerulus is a
network of capillaries
which filters the blood
Products which are filtered out:
water, mineral salts, amino acids,
glucose, hormones, urea, toxins
Products which do not filter
and remain in the blood:
Leukocytes, erythrocytes,
platelets, plasma proteins
The filtered substances
move into the proximal
convoluted tubule
The PCT is concerned with
reabsorption- organic nutrients are
reabsorbed and water follows
because there is a concentration
gradient
The remaining filtrate moves
into the descending loop of
henle. This is lined with thin
cells so water moves out
Because water has been
reabsorbed the concentration
of the filtrate is not very high
The walls of the ascending loop
of henle are lined with thicker
cells, so water cant pass in or
out. Instead sodium and
chloride is pumped out actively
The filtrate now enters the
distal convoluted tubule- is it
now only 20% of what it
originally was.In the DCT the volume and
composition of the filtratecan be adjusted but this is
controlled by hormones
From the DCT the filtrate now
passes into the collecting duct.
A number of other nephrons join
up to the cleectig duct which
travels through the medulla to therenal papilla wher the filtrate is
emptied in the minor calyx
- minor calyces join up to
make a major calyx
2- major calyces join up
to form the renal pelvisThe renal pelvis joins the
ureter at the hilum
The ureter transport the
filtrate/urine from the kidney
to the bladder
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3 processes involved in the formation of urine.
Simple filtration
Selective reabsorbtion Hormonal control-
Parathyroid hormone, calcitonin
Anti diuretic hormone
Aldosterone
Secretion
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Superiorly Continuous with the renal
pelvis
Inferiorly
Pass through the abdominalcavity, behind theperitoneum, infront of thepsoas muscle, into thepelvic cavity ehere theyenter the posterior wall ofthe bladder
25-30 cm in length
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3 layers of tissue
Outer layer Fibrous tissue
Middle layer Muscle
Inner layer
Epithelium
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3 layers
Outer layer Loose connective tissue
Middle layer Smooth muscle and
elastic fibres
Inner layer Lined with transitional
epithelium
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Extends from thebase of the bladderto the outside world.
Anatomicaldifferences meanthat male and femaleurethras are
different. Female: 4cmlong
Male: 14cmlong
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Muscle layer
Submucosa layer
Mucosa
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