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Kidneys Your kidneys are bean-shaped organs, each about the size
of your fist. They are located near the middle of your back, just below the rib cage. The waste and extra water become urine.
Each kidney is about 11 cm long 5 cm wide and 3 cm thick and weighs 130 grams.
kidneys The filtration occurs in nephrons, every kidney has about 1
million nephrons. The driving force of the filtration is blood pressure. The 4 basic components are renal corpuscle, proximal
convoluted tubule, loop of henle, and distal convoluted tubule.
Definition Notch on the inner border of the kidney where the renal
artery, renal vein, and ureter connect with the kidney Nerves and renal artery enter renal vein and ureter exit Opens into renal sinus
Cavity filled with tissue Structures that enter and leave kidney pass through
Connections Renal artery
Carries all blood from body into the kidneys Nerves
Sympathetic neurons regulate renal blood flow and filtrate formation Osmoreceptor cells detect changes in osmolality and stimulate ADH
secreting neurons Regulates osmolality
Renal Vein Takes filtered blood away from kidney and to the heart through inferior
vena cava Ureter
Carries urine (waste) from kidney to the urinary bladder
Ureter Function: Tube that carries urine from kidney to the bladder Ureteral stones (concentrated materials that form into solid
crystals in the urine) Kidney stone that’s left kidney and now in ureter
Urinary tract cancer Cancer cells found in tissues lining in ureter
Structure: Originates from base of kidney and terminates in the base of the bladder Each kidney has one ureter measuring from 28-34 cm
long (right’s slightly longer than left)
Urethra Urine is transported outside the body through this opening inferiorly and anteriorly.
It is a triangular area of wall between the 2 ureters posteriorly; the anterior urethra is called the trigone.
In females is id 1.5 inches long and only part of the urinary system
In males it is much longer- 8 inches and part of both the urinary and reproductive systems.
Disorders of the UrethraHypospadias- urethra opens on the under surface of the penis instead of at the end (in males only-obviously)
Urethritis- inflammation of mucous membrane and glands of uretha
“Straddle” injuries- ruptured urethra
Life • First step towards urine formation
• Cleans out plasma• Blood plasma spills out of glomerular capsule
• Blood comes from kidneys via renal artery smaller arteries afferent arteriole Glomerulus Plasma spills out Glomerular capsule
• Made of:• Electrolytes• Nutrients (ex: Monomers)• Wastes• Small hormones• Water
• Can’t fit through:• Cells• Plasma
WHAT YOU NEED TO KNOW Occurs when the nephron specifically returns water and
some filtered molecules to the blood The filtered molecules leave the bowman capsule and go
through PCT, Loop of Henle, DCT, collecting ducts putting the molecules into the interstitial fluid then into the bloodstream
MORE STUFF TO KNOW Removes toxins from blood Without proper tubular reabsorption the body would become
dehydrated and deficient
Urine Can be diluted or very concentrated
Concentration and volume are regulated by mechanisms that maintain the extra cellular fluid osmolality and volume within narrow limits.
If water must be conserved to maintain homeostasis, water is reabsorbed from the filtrate as it passes through the distal convoluted tubules and collecting ducts. This results in a small volume of very concentrated urine.
Hormonal Mechanisms Renin-angiotensin-aldosterone hormone
renin is an enzyme secreted If secretion decreases blood pressure increases
Antidiuretic Hormone Without it makes tubules and collecting ducts impermeable If not enough produced 19% of filtrate becomes part of the urine
Called diabetes insipidis Too much is diabetes mellitus
Diseases/Disorders Glomerulonephritis Acute Glomerulonephritis Chronic Glomerulonephritis Pyelonephritis Renal Failure Acute Renal Failure Chronic Renal Failure Urinary Bladder Cancer Kidney stones
Cystitis Nephrongenic Diabetes
Insipidus Diabetic Nephropathy Polycystic Kidney Disease
Urinary BladderLibby and Brittany
Temporary reservoir for urine; hollow, muscular container
Location: pelvic cavity just posterior to the symphysis pubis Males: anterior to the rectum; Females: anterior to the
uterus Volume increases and decreases depending on amount
of urine Max volume is 1 L (about 1 quart) Uncomfortable feeling at 500 mL
Wall is thicker than wall of ureter Contraction of smooth muscle forces urine out
All You Need to Know The movement of non-filtered substances, toxic by-products
of metabolism and drugs or molecules not normallly produced by the body, from the blood into the filtrate
The main types are active and passive transport Passive example– Ridding the body of ammonia because it is
toxic Active– para-aminohippuric acid is forced out of the body
because it is not being used