Embed Size (px)
Citation preview
University of Groningen
Towards an optimal clinical protocol for the treatment of moving targets with pencil beamscanned proton therapy Ribeiro, Cássia O.
DOI:10.33612/diss.126443635
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.
Document VersionPublisher's PDF, also known as Version of record
Publication date:2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):Ribeiro, C. O. (2020). Towards an optimal clinical protocol for the treatment of moving targets with pencilbeam scanned proton therapy. University of Groningen. https://doi.org/10.33612/diss.126443635
CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.
Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.
Download date: 21-05-2022
Cover and chapter separators: Jorge Oliveira [email protected]
Layout: Lovebird design. www.lovebird-design.com
Financial support for the publication of this thesis was kindly provided by:• University of Groningen and the Graduate School of Medical
Sciences• University Medical Center Groningen• RaySearch Laboratories
Printed by: Eikon+
ISBN: 978-94-034-2749-2ISBN (e-book): 978-94-034-2750-8
Copyright @C.Oraboni Ribeiro, Groningen, the Netherlands, 2020All rights reserved. No part of this thesis may be reproduced in any form or by any means without prior permission of the author.
Towards an optimal clinical protocol for the treatment of
moving targets with pencil beam scanned proton therapy
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
dinsdag 9 juni 2020 om 11.00 uur
door
Cássia Oraboni Ribeiro
geboren op 7 januari 1991 te Curitiba, Brazilië
PromotoresProf. dr. A.C. Knopf Prof. dr. J.A. Langendijk
CopromotorDr. ir. E.W. Korevaar
BeoordelingscommissieProf. dr. S. Brandenburg Prof. dr. B.W. Raaymakers Prof. dr. J. Widder
CONTENTS
Chapter 1 General Introduction .............................................................7
Chapter 2 Comprehensive 4D robustness evaluation for pencil beam scanned proton plans ................................27
Chapter 3 Assessment of dosimetric errors induced by deformable image registration methods in 4D pencil beam scanned proton treatment planning for liver tumours ...................................................................45
Chapter 4 Towards the clinical implementation of intensity- modulated proton therapy for tho-racic indications: evaluation of 3D vs. 4D robust optimisation by means of patient and machine specific information.............................................................77
Chapter 5 Evaluation of intrinsic ‘rescanning’ (pulsed beam) versus scaled rescanning (continuous beam) for the treatment of moving targets with pencil beam scanned proton therapy ......................... 109
Chapter 6 Deformable image registration uncertainty for inter-fractional dose accumulation of lung can-cer proton therapy ............................................................. 129
Chapter 7 Discussion and future perspectives ............................. 159
Appendices .................................................................................... 183 Summary ...............................................................................185 Samenvatting .......................................................................191 Acronyms .............................................................................. 197 Publications ......................................................................... 199 Acknowledgements ...........................................................202 Curriculum Vitae ................................................................211
