Trends in drug delivery (vol1, issue2)

Trends in Drug Delivery

(TDD)

May - August 2014

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Editorial Board

Dr. A.J. VanisreeAssistant Professor, Department of Biochemistry University of Madras,

Chennai, India.

Dr. Anil BansalChairman, Department of

Pharmacology, J. N. Medical College, AMU, Aligarh, India.

Dr. Bhavin Marolia Assistant Prof., Dept. of Quality

Assurance & Pharmaceutical Analysis, Maliba Pharmacy College,

Bardoli, India.

Divya SuaresAssistant Professor, NMIMS

University, India.

Dr. Ashwin KotnisAssistant Professor, Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, India.

Dr. Abhay DharamsiProf. & Head, Dept. of Pharmaceutics,

Maliba Pharmacy College, Gujarat, India.

Gautam SinghviDepartment of Pharmacy,

BITS, Pilani, India.

Dr. Jayarajakumar KalaimaniFaculty of Pharmacy, AIMST University,

Bedong, Malaysia

Dr. Kashmira GohilProfessor and HOD, Shree

Dhanvantari Pharmacy College, Gujarat, India.

Dr. Koteshwara K.BProfessor Dept. of Pharmaceutics, Manipal

College of Pharmaceutical Sciences, Manipal University, India

Dr. Mahalaxmi RathnanandAssociate Prof., Dept. of Pharmaceutics

Manipal College of Pharmaceutical Sciences, Manipal, India.

Dr. Mayur PatelAssociate Professor, Dept. of

Pharmaceutical Science, Institute of Pharmacy, Nirma University, Ahmedabad,

Gujarat, India.

Editorial Board

Dr. NayanaAssociate Professor, Pharmacology,

J N Medical College, Belgaum, India.

Dr. Rafik KaramanFaculty of Pharmacy Al-Quds

University, Jerusalem.

Dr. S. Shanmugam Prof. & Head, Dept. of Pharmaceutics, Adhiparasakthi College of Pharmacy,

T.N, India.

Dr. Shashank K SinghSenior Scientist, CSIR-Indian institute of

Integrative Medicine , Canal Road Jammu, India

Dr. S. K. M. HabeebAssistant Prof., Dept. of Bioinformatics,

School of Bioengineering, SRM University, India.

Dr. Pranav ShahAssociate Professor, Maliba

Pharmacy College, Surat, Gujarat, India.

Soh Yee ChangLecturer, Faculty of Pharmacy, UiTM Puncak Alam Campus,

Malaysia.

Sonia PandeyAssistant Professor, Maliba Pharmacy College Uka Tarsadia University, Surat,

Gujrat, India.

Dr. Srinivas MutalikAssociate Professor, Department of Pharmaceutics, Manipal University,

India.

Dr. Tripura SundariAssistant Professor, SPPSPTM, NMIS,

Mumbai, India.

Dr. V. RavichandranFaculty of Pharmacy, AIMST University, Semeling ,Kedah,

Malaysia.

Dr. Viral Dineshchandra JagiwalaAssistant Professor, Shree Dhanvantary

Pharmacy College,Gujarat, India.

Editorial Board

Dr. Ganga Srinivasan Professor in Pharmaceutics at VES

College of Pharmacy, Mumbai, India.

Dr. Vivek BhosaleScientist, Division of Clinical and

Experimental Medicine CSIR-Central Drug Research Institute,

India.

Dr. Yahaya Bin HassanHead, Faculty of Pharmacy, Universiti Teknologi MARA(UiTM) Malaysia.

Dr. Santanu ChakrabortyAssistant Professor, Department:

Pharmaceutics, Dr. B. C. Roy Engineering College, Kolkata, India.

Dr. Sandip Prabhakar ZineAssistant Professor, Department of

Pharmaceutical Chemistry,Vivekanand Education Society's College of Pharmacy,

Mumbai, India.

Dr. Nahlah Elkudsiah IsmailFaculty of Pharmacy, Universiti

Teknologi MARA (UiTM) Puncak Alam Campus, Bandar Puncak

Alam, Selangor, Malaysia.

Dr. Mudit DixitAssistant Professor,

(Pharmaceutics) (Senior Grade), NGSM Instituteof Pharmaceutical

Sciences, Mangalore, India.

I take the privilege to present the print version for the Volume 1 Issue (2) of Trends in Drug Delivery.

The intension of TDD is to create an atmosphere that stimulates creativeness, research and growth in

the area Drug Delivery.

The development and growth of the mankind is the consequence of brilliant Research done by

eminent Scientists and Engineers in every field. TDD provides an outlet for Research findings and

reviews in areas of Drug Delivery found to be relevant for National and International recent

developments & research initiative.

The aim and scope of the Journal is to provide an academic medium and an important reference for

the advancement and dissemination of Research results that support high level learning, teaching and

research in the domain of Drug Delivery.

Finally, and Authors for their continued support and invaluable contributions and suggestions in the

form of authoring I express my sincere gratitude and thanks to our Editorial/ Reviewer board write

ups/ reviewing and providing constructive comments for the advancement of the journals. With

regards to their due continuous support and co-operation, we have been able to publish quality

Research/Reviews findings for our customers base.

I hope you will enjoy reading this issue and we welcome your feedback on any aspect of the Journal.

Dr. Archana Mehrotra

Director

STM Journals

Director's Desk

STM JOURNALS

1. Synthesis and Electrochemical Study of 1-[2', 4'-dinitrophenyl)-3, 5-dimethyl-4- [4''-(substituted)sulphonamoylphenyl] Azopyrazoles Shrinarayan Karaiya, Ritesh Mishra, Ramji Lal Yadav, Virendra K. Arya, Hitesh Malvia 1

2. Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam Mudit Dixit, P. K. Kulkarni, R Narayana Charyulu 8

3. Regenerative Endodontics: Nano 3D scaffolds as Dental Materials and Stem Cells for Dental Tissue Regeneration

Rachna Dhani, Shashank K Singh 14

4. Intrapocket Drug Delivery System: A Spatial Tool for Periodontitis Jain J., Srinivasan G. 24

ContentsTrends in Drug Delivery

TDD (2014)© STM Journals 2014. All Rights Reserved


Volume 1, Issue 2

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Synthesis and Electrochemical Study of

1-[2′, 4′-dinitrophenyl)-3, 5-dimethyl-4-

[4′′-(substituted)sulphonamoylphenyl] Azopyrazoles

Shrinarayan Karaiya1*, Ritesh Mishra

2, Ramji Lal Yadav

1,

Virendra K. Arya1, Hitesh Malvia

3

1School of Studies in Chemistry, Jiwaji University, Gwalior, India

2Analytical Research & Development Department, Medilux Laboratories Pvt. Ltd.

Pithampur, Dist. Dhar, India 3School of Chemical Sciences, DAVV, Indore, India

Abstract Electrochemical behavior of 1-(2',4'-dinitrophenyl)-3,5-dimethyl-4-[4"-(substituted)

sulphonamoylphenyl] azopyrazole (DDSPA) was studied in Britton-Robinson (BR) buffer range of pH 3.5–12 at dropping mercury electrode (DME) and glassy carbon electrode

(GCE). Cathodic differential pulse polarographic peak is obtained at DME in the pH

range 3.5–12. Cyclic voltammogram exhibited a well-defined, irreversible cathodic and anodic peak at GCE. At pH 3.5–12, the reduction peak exhibited a tendency to split into

two peaks. The first 8e- peak has been assigned to the reduction of two nitro groups to

hydroxylamine group and second 2e-

peak has been assigned to the reduction of azo

group to hydrazono group (–NH–NH–). A product of controlled potential electrolysis

(CPE) was characterized by elemental and spectral analysis.

Keywords: azopyrazoles, polarography, voltammetry, CPE, electrochemistry



Volume 1, Issue 2

www.stmjournals.com

Formulation and Evaluation of Transdermal Drug

Delivery of Piroxicam

Mudit Dixit1*, P. K. Kulkarni

2, R Narayana Charyulu

1

1Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Nitte University,

Mangalore, Karnataka, India 2Department of Pharmaceutics, J.S.S College of pharmacy, J.S.S University, Mysore, India

Abstract The aim of the present study was to formulate transdermal films loaded with Piroxicam

(PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum

(XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for

thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam was found to be compatible and stable with the prepared

formulation as confirmed by Fourier transform infrared spectroscopy (FTIR) and

Differential Scanning Calorimetry (DSC), studies. Invitro release studies revels effectiveness after 24 h. The study results suggest that biopolymer based Transdermal

films are potential vehicles for improved transdermal delivery of PX for effective therapy.

Keywords: Piroxicam, Sodium alginate, Xanthan gum, Transdermal release, Skin

permeation



Volume 1, Issue 2

www.stmjournals.com

Regenerative Endodontics: Nano 3D scaffolds as Dental

Materials and Stem Cells for Dental Tissue Regeneration

Rachna Dhani1, Shashank K Singh

2* 1Department of Conservative Dentistry & Endodontics Indira Gandhi Government Dental

College and Hospital, Jammu, India 2Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine

Canal road, Jammu, India

Abstract In dentistry, for maintaining any tissue in a healthy state, focus is on prevention,

treatment and repair of the diseased tissue. Current treatments for diseases of tooth

structures rely on the use of classical endodontic procedures which in some cases are

limited success rate. The use of stem cells in regenerative therapies have been shown to have promising applications in various debilitating diseases like neurodegenerative

disease, diabetes, cancer and dental diseases etc. Regenerative dentistry is addressing various complications involves the in vitro creation of cells/tissues for replacement

therapy that stimulate the body’s own regenerative capabilities. Regenerative dentistry

represents an attractive multidisciplinary therapeutic approach that combines traditional restorative/surgery techniques and benefits from recent advances in stem cell biology,

genomics, proteomics and material sciences. Dental Pulp Stem Cells or (DPSCs) are well characterized multipotent stem cells that have the potential to differentiate into a variety

of cell types used for regenerating the tooth. Regenerating and reengineering the decayed

pulp structure requires the design of scaffolding materials that mimic the architecture of a natural dental extracellular matrix (ECM) and provide suitable environments for the

attachment, proliferation, differentiation, and biomineralization of dental pulp stem cells

(DPSCs) to grow. Three-dimensional (3D) biocompatible hybrid scaffolds mimic the nano-structured architecture and chemical composition of a natural dental ECM. DPSCs

had a significantly higher proliferation rate on 3D hybrid scaffolds. Hybrid scaffolds significantly promote the differentiation and bio mineralization of the human DPSCs. In

summary, using the Hybrid Nano 3D scaffolds which provides an excellent environment

for the growth and differentiation of human DPSCs and are promising treatment modality in endodontic procedures for dentin/pulp tissue regeneration and restoration of

natural tooth.

Keywords: Embryonic Stem Cells (ESC), pluripotent stem (iPS), Dental Pulp Stem

Cells, or (DPSCs), (3D) scaffolds



Volume 1, Issue 2

www.stmjournals.com

Intrapocket Drug Delivery System: A Spatial Tool

for Periodontitis

Jain J., Srinivasan G.* VES College of Pharmacy, Chembur, Mumbai, India

Abstract Periodontitis is a disease attributable to multiple infectious agents. It results from

extension of the inflammatory process initiated in the gingiva to the supporting

periodontal tissues. Periodontal pockets provide natural reservoir bathed by gingival crevicular fluid that is easily accessible for the insertion of a delivery device. Intra-

pocket, sustained release systems have emerged as a novel paradigm for the future

research. Controlled release delivery of antimicrobials is a therapeutic intervention directly into periodontal pockets and is available in various forms like gels, monolithic

devices, irrigation systems, chips, films, strips, microspheres, fibers, etc. It is an effective monotherapy that has evoked a great interest and appears to hold a sound promising

result in periodontal treatment these local agents bypass the adverse effects of

systemically administered antimicrobial agents, as well stabilize the attachment apparatus and reduce the probing depth thereby allowing better control and management

of periodontal disease.

Keywords: gingivitis, periodontitis, local drug delivery, periodontal pocket

Documents

Trends in drug delivery (vol1, issue2)