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Transforming the CTRI and UCSD:From Silo to Collaboration
Gary S. Firestein, M.D.
Clinical and Translational Research Institute
• Organized Research Unit, est. 2010• Funded by institutional funds, CTSA, CTSA supplements,
UCOP, industry funding and NHLBI U54• ~$59 M extramural funding
• Informatics, clinical research and laboaratory infrastructure• Pilot project and Catalyst grants• KL2/TL1/CREST programs• co-funding of investigator initiated projects (30-60%)
• ~$50 M in grants requiring CTRI letter of support• 782 members
• 655 UCSD• SDSU, Sanford Burnham, Salk, LIAI, Venter, others
2010 2011 2012 2013
Nurses/Coord Nurses/Coord Nurses/Coord Nurses/Coord
Clinical Cores--DEXA--Exercise
Clinical Cores--DEXA--Exercise
Clinical Cores--DEXA--Exercise--Skin biopsy
Clinical Cores--DEXA--Exercise--Skin biopsy--Cardiac phenotype
Biostatistics Biostatistics Biostatistics Biostatistics
IRB service IRB service IRB service
Clinic Space (ECOB)
Clinic Space (ECOB)
Phase I unit
Center for Clinical Research 2010-2013
Clinical and Translational Research Institute
• Clinical services since 2011• 261 protocols in CCR (108 currently active)
• ~3000 visits/year• 93 infusions (56 in first half of 2013)• 220 skin biopsies • 45 IRB submission consultations
New CTRI to break down silos• Phase I unit
• Collaboration with the Cancer Center• Standard of Care billing• Experimental Pharmacy• Overnight stays• Begin in ECOB, then move to ACTRI
2010 2011 2012 2013
Biomarker Biomarker Biomarker Biomarker
Biorepository--Storage
Biorepository--Storage--Collection--Velos
Biorepository--Storage--Collection--Velos--Management
Affiliated Cores--Mass Spec
Affiliated Cores--Mass Spec--HT screening
Affiliated Cores--Mass Spec--HT Screening--Genomics
Launching Pad
Translational Research Technology 2010-2013
2010 2011 2012 2013
CDWR CDWR CDWR CDWR
CRIQueT CRIQueT CRIQueT
REDCap REDCap REDCap
ReX ReX
Biocomp Center--Genomics
Biocomp Center--Genomics--Epigenomics--Systems Biology
Velos Enterprise Velos
Data Concierge
Biomedical Informatics 2010-2013
Clinical and Translational Research Institute
• Informatics and Biomarker services since 2011• 485 protocols in Velos (252 active)• 62 Bioinformatics projects• 99 Biomarker projects• 19,027 biosamples processed or collected• 18,392 biomarker assays performed
New CTRI to break down silos
• Genomics and bioinformatics• Consolidate individual efforts at various centers in
the Institute for Genomic Medicine• Re-engineer BIOGEM• Center for Bioinformatics Analysis• Integrated assistance with study design, data
analysis, systems biology, ‘omics data• Collaboration and service models
CTRI Funding Education
• CTRI TL1 Program• 3 m or 1 yr training for medical and pharmacy students
• CTRI KL2 Program• Institutional K award $100 K/yr• 10 Scholars funded since 2010• ~80 participants
• CTRI CREST Program• Modular program that can lead to MAS• Co-funding by the CTRI to lower tuition• >100 participants
Simplifying access: ctri.ucsd.edu
2010 2011 2012 2013
Translational Translational Translational Translational
Clinical Clinical Clinical Clinical
Innovation Innovation Innovation Innovation
Catalyst--CTRI services
Catalyst --CTRI services
Catalyst --CTRI services--Biomarkers--Drug discovery
Personalized Medicine
Engineering in Medicine
Co-funding with other centers
Pilot project grant program 2010-2013
Resources available at the CTRI: Catalyst grants
New CTRI to break down silos
• Drug Discovery at Sanford-Burnham• High throughput screening• Catalyst grants
Resources available at the CTRI: Pilot project grants
CTRI Funding Innovation
Bringing engineers and clinicians together to apply technology to unmet medical needs
GEM Program:Galvanizing Engineering in Medicine
Altman CTRI Building: Designed to break down silos