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TIBCO Spotfire for Discovery Research

How Visual Analysis Can Accelerate Insights

David Mosenkis, Solutions Consultant September, 2010

http://spotfire.tibco.com/spotfire-for-you/by-industry/life-sciences/lead-discovery.aspx

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The power of Visual Analytics

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How many 3’s?

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ValidationHTS

Lead

OptimizationADME Toxicology Clinical Manufact

Spotfire Across the Pharma Enterprise

PV

One user experience for analytics - Unified data retrieval - Configurable

to any business process

Sales &

Marketing

Proteomics

Systems

Biology

Biomarker Research

Pharmacokinetics

Compound

Profiling

Pharmacology

Biostatistics

Exploratory

Development

Toxicology.

Animal Studies

Screening

Safety and Risk Mgmt

Portfolio Assessment

Competitive

Efficacy

Physician Targeting

Segmentation

Gene

Expression,

Bioinformatics

Adverse Events

Data Monitoring

Call Planning

Sales Force

Effectiveness

Hit Selection

Combinatorial Chemistry

Computational Chemistry

Clinical Pathology

Biostatistics

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What is Spotfire?

Unique interactive visual

analytics to spot trends, outliers

and other hidden relationships in

data

Applicable to many different

types of data

Easily accesses data from

multiple, disparate sources

(Oracle, Excel, SAP, etc.)

Helps deploy best practices

Extensible platform with an open

SDK

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TIBCO Spotfire: One Platform, Many Applications

HCS, HTS Project KPIs

SAR Competitive Intelligence Gene Expression

Kinase Inhibitors

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Spotfire Integration with ChemAxon

JChem Cartridge

Spotfire Server

MarvinView

Spotfire Client

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Chemistry Project Dashboard

For: Team Leaders, Project Managers, Scientific Management

How is my project doing vs. goals?

Which series looks most promising?

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SAR

For: Medicinal Chemists, Computational Chemists, Biologists

Are there trends? Outliers?

What’s the structural basis for observed activity?

What should I make next?

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Selectivity Analysis

For: Screening Biologists, Lead Chemists

How do my compounds behave across targets?

Which compounds are selective, and why?

Which compounds should advance?

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Dose Response

For: Screening Biologists, Team Chemists

How do my lead compounds behave in different assays?

How do my lead compounds compare to a reference compound?

How reliable are my IC50 values?

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High Throughput Screening

For: Screening Biologists, Team Chemists, Team Biologists

How do I detect systematic quality issues?

How do I identify hits?

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Competitive Analysis

For: Researchers, Managers

Where is my company strong and weak?

What therapeutic areas, diseases, mechanisms are best to

target?