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The Lighter Side They Call the Stuff Urea (To the Tune of ‘‘They Call the Wind Mariah’’) & s Received for publication, June 11, 2010 Kevin Ahern† From the Department of Biochemistry, Oregon State University, Corvallis, OR 97331 Get ATPs, bicarbonate, Ammonia catalyzing To make carba-mo-yl phosphate And then start the synthesizing When joined up with an ornithine In THE mi-TOE-chon-DREE-a It turns into a citrulline When cycling to urea Urea! Urea! They call the stuff urea! On exit to the cytosol There’s bonding aspartat-ic The argininosuccinate Is produced in this schematic Bid farewell to a fumarate Amino panacea Arises when the arginine Gets lysed to form urea Urea! Urea! You’ve just made some urea! The body handles many things Requiring its attention Like balancing aminos for Uremia prevention So if there’s excess nitrogen It is a good idea To rid yourself of surplus by Producing some urea Urea! Urea! Go out and take a pee, yeah! Urea! Urea! Have yourself a pee, yeah! Copyright Ó 2010 Kevin Ahern & s Additional supporting information (an .mp3 file of this song) may be found in the online version of this article. † To whom correspondence should be addressed. ALS 2011, Corvallis, Oregon 97331, USA. Tel.: 541-737-2305. E-mail: [email protected]. This paper is available on line at http://www.bambed.org DOI 10.1002/bmb20449 247 Q 2010 by The International Union of Biochemistry and Molecular Biology BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION Vol. 39, No. 3, pp. 247, 2011

They call the stuff urea (to the tune of “they call the wind Mariah”)

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The Lighter Side

They Call the Stuff Urea (To the Tune of ‘‘They Call the Wind Mariah’’)&s

Received for publication, June 11, 2010

Kevin Ahern†

From the Department of Biochemistry, Oregon State University, Corvallis, OR 97331

Get ATPs, bicarbonate,Ammonia catalyzingTo make carba-mo-yl phosphateAnd then start the synthesizing

When joined up with an ornithineIn THE mi-TOE-chon-DREE-aIt turns into a citrullineWhen cycling to urea

Urea!Urea!

They call the stuff urea!

On exit to the cytosolThere’s bonding aspartat-icThe argininosuccinateIs produced in this schematic

Bid farewell to a fumarateAmino panaceaArises when the arginineGets lysed to form urea

Urea!Urea!You’ve just made some urea!

The body handles many thingsRequiring its attentionLike balancing aminos forUremia prevention

So if there’s excess nitrogenIt is a good ideaTo rid yourself of surplus byProducing some urea

Urea!Urea!Go out and take a pee, yeah!

Urea!Urea!Have yourself a pee, yeah!

Copyright � 2010 Kevin Ahern&s Additional supporting information (an .mp3 file of this

song) may be found in the online version of this article.† To whom correspondence should be addressed. ALS

2011, Corvallis, Oregon 97331, USA. Tel.: 541-737-2305.E-mail: [email protected].

This paper is available on line at http://www.bambed.org DOI 10.1002/bmb20449247

Q 2010 by The International Union of Biochemistry and Molecular Biology BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Vol. 39, No. 3, pp. 247, 2011