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2
THE PUREST PROBIOTIC ON EARTH
WITH INNOVATIVE APPLICATIONS AS:
HEALTH AND NUTRITION
FOOD SPECIALTY
TM
THE PUREST PROBIOTIC ON EARTHTM
3
WHAT IS PROVIOTIC?
Plant based good bacteria (L. bulgaricus GLB44) Extracted from the Snowdrop flower in the mountains of Southeast Europe Grown in certified organic vegetable juice. Contains only L. bulgaricus GLB44 and traces
of organic vegetables. There are no carriers, no fillers, no preservatives, no artificial ingredients.
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1. HUMAN HEALTH AND NUTRITION PROVIOTIC AS A DIEATARY SUPPLEMENT
THE ONLY PROBIOTIC THAT IS DISCOVERED ON A FLOWER AND GROWN IN JUICE Certified organic 100% vegan No major allergens (lactose free, gluten free, soy free, nuts free) No artificial ingredients No GMO No bloating (homofermentative) Researched by Harvard Medical School scientists
COMPARISON WITH KEY COMPETITORS
BIOGAIA CULTURELLE
BIO -K PLUS (capsules)
GARDEN OF LIFE
ULTIMATE FLORA
DR. OHHIRA’s
Major Allergens
NO MAJOR
ALLERGENS SOY
GOODBELLY FLORASTOR ALIGN
LACTOSE LACTOSE LACTOSE SOY
LACTOSE AND SOY
LACTOSE AND SOY
LACTOSE
Animal Products
ANIMAL PRODUCTS
ANIMAL PRODUCTS
ANIMAL PRODUCTS
ANIMAL PRODUCTS
ANIMAL PRODUCTS
BEE PRODUCTS
ANIMAL PRODUCTS
Artificial Ingredients
NO ARTIFICIAL
INGREDIENTS
Triglyceride Magnesium
Stearate Titanium Dioxide
Magnesium Stearate Titanium Dioxide
Sodium Ascorbate
Silicon Dioxide
Magnesium Stearate
Trisodium Citrate
Magnesium Stearate Titanium Dioxide
Undefined Glycerin
Carrageenan
Magnesium Stearate
Maltodextrin
Triglyceride Sodium Dioxide
NOT ORGANIC
Certified Organic
NOT ORGANIC
NOT ORGANIC
NOT ORGANIC
NOT ORGANIC
NOT ORGANIC
NOT ORGANIC
NOT ORGANIC
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HARVARD MEDICAL SCHOOL AND BRIGHAM AND WOMEN’S HOSPITAL Researchers: Dr. Onderdonk, Dr. Fichorova Inhibition of E. coli, Listeria, Salmonella in raw foods with ProViotic Eradication of H. pylori in infected patients with ProViotic Control of vaginal infections with ProViotic
SCIENCE AS A CORE COMPETITIVE ADVANTAGE
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Harvard Medical School Inhibition Test: Inhibition of E. coli 0157:H7
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GROUP A:
Alcohol Free Beverages
Harvard Medical School Inhibition Test: Inhibition of Salmonella typhimurium
9
Confocal Microscope Images of How ProViotic
Destroys E-coli Biofilm
10
Con
tro
l w
ith
ou
t G
LB
44
Con
tro
l w
ith
ou
t G
LB
44
GL
B4
4
GL
B4
4
Confocal Microscope Images of How ProViotic
Destroys E-coli Biofilm
11
Apple Cider Organic Alcohol Free
% Inhibition using G-LB-44 @ 1X
Inhibition Rate
Organism Strain
Acinetobacter baumanii ATCC 19606 >99
Enterococcus faecalis ATCC 29200 >99
Enterococcus faecalis ATCC 29212 >99
Enterococcus faecium ATCC 51559 >95
Esherichia coli ATCC 25922 100
Esherichia coli ATCC 35150 >99
Listeria monocytogenes ATCC BAA-751 100
Listeria monocytogenes Clinical Isolate 100
Psuedomonas aeruginosa ATCC 27853 100
Salmonella typhimurium Clinical Isolate
Shigella sonnei ATCC 325931 100
Staphylococcus aureus ATCC 12600 >99
Staphylococcus aureus ATCC 25923 >99
Staphylococcus aureus ATCC 29213 >98
SUMMARY OF PATHOGEN INHIBITION TESTS
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More products in 0.0% CONTINUOUS RESEARCH ON GUT PATHOGENS WITH NOBEL PRIZE WINNER FOR MEDICINE DR. MARSHALL
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GROUP B:
Ultra-Low-Alcohol Beverages 0.45%vol.
2015: First Human Trial – 22 patients Eradicating of H. pylori with 92% Success Rate
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Apple Cider Ultra-Low-Alcohol 2015: Second Human Trial – 52 patients
Eradicating of H. pylori with 92% Success Rate
To evaluate the effect of Lactobacillus
delbrueckii subsp. bulgaricus GLB44 in
commercially available form on Helicobacter
pylori infection in combination with a proton-
pump inhibitor.
Methods
Conclusions
Lactobacillus bulgaricus GLB44 - promising results in
Helicobacter pylori infection
Bibliography
Fifty two patients (57.7% female) at mean age
43.52±13.4y were enrolled in our study after
esophagogastroduodenoscopy. All patients
were Helicobacter pylori (HP) positive
diagnosed either by rapid urease test, stool
antigen test and histology examination, or by a
combination of these methods. Ten (19.2%) of
the patients had HP eradication at some point
in the past. Every patient was given
Lactobacillus bulgaricus GLB44 (capsules and
tablets) in daily doses of 15x109 living cells
together with a proton pump inhibitor
(rabeprazol, pantoprazol, esomeprazol or
omeprazol) 20 mg bid for 7 days, followed by
GLB44 alone for 3 days at the same dose. All
patients were retested for HP after at least 43
days.
1. Boyanova, L.; Stephanova-Kondratenko, M.; Mitov, I. (May 2009). "Anti-
Helicobacter pylori activity of Lactobacillus delbrueckii subsp. bulgaricus
strains: preliminary report". Letters in Applied Microbiology 48 (5): 579–84.
After the administration of Lactobacillus
bulgaricus GLB44 92.3% of all HP positive
patients had negative HP control tests
(p<0.001). Four patients were still HP positive
and one of them had previous unsuccessful
antimicrobial eradication course.
Lactobacillus delbrueckii subsp. bulgaricus
has in vitro inhibitory properties against H.
pylori.1 Per oral route of administration of
adequate probiotic dose in combination with
PPI is a promising treatment modality in HP
positive patients.
Objective Results
E-mail: [email protected]: None
HP positive beforeGLB44 HP positive after
GLB44
100%
7,7%
HP/+/pos. patients before and after Lactobacillus bulgaricus GLB44 + PPI course
Heartburn Epigastricpain
Dyspepsia Bleeding Other
32.70%
11.50%
48.10%
3.80% 3.80%
Clinical Presentation
Yana Valerieva1, Borislav Vladimirov1, Ivan Terziev2, Lyudmila Boyanova3
1 Clinical Centre of Gastroenterology, 2Department of Pathology, University Hospital “Queen Joanna – ISUL”, Sofia, Bulgaria3 Department of Microbiology, Sofia, Bulgaria
Medical University of Sofia
0%10%20%30%40%50%60%70%80%90%
HP Tests Used
Diagnostic test
Control test
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Grape Cider Ultra-Low-Alcohol PROVIOTIC HAS THE STRONGEST PATHOGEN
INHIBITION PROPERTIES
55.9%
22.5%
15.0%
100.00%
100.00%
100.00%
100.00%
78.4%
0.00%
0.00% Inhibits
(no rates found)
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
BIOGAIA CULTURELLE
BIO -K PLUS (capsules)
GARDEN OF LIFE
ULTIMATE FLORA
DR. OHHIRA’s GOODBELLY FLORASTOR ALIGN
E. coli
Salmonella t.
Listeria m.
S. aureus
A. baumanii
E. faecalis
E. faecium
No information found
Inhibits (no rates found)
No information found
Inhibits (no rates found)
PATHOGEN INHIBITION RATE IN VIVO
Dr. Onderdonk Harvard
Medical School Professor
PROBIOTIC STRAIN RESEARCH
Dr. Casas University
Laboratory at Lima, Peru
Dr. Gorbach, Dr. Goldin
Tuft University
Dr. Millette Université du
Québec, Canada
Dr. Mulin Lund
University Sweden
Dr. Delmasso University of
Nice France
Dr. Rao University of
Toronto Canada
Dr. Brenner University Feinberg School of
Medicine, USA
Dr. Smith Renew Life
Florida, USA
Dr. Ohhira Okayama
University, Japan
90.0%
23.5%
0.00% 0.00%
100.0%
84.7%
75.3%
73.5%
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
No information found
Inhibits (no rates found)
Inhibits (no rates found)
Inhibits (no rates found) 100.00%
100.00%
99.86%
99.68%
77.2%
no information found
98%
Inhibits (no rates found)
Inhibits (no rates found)
No information found
No information found
P. aeruginosa
16
Pear Cider Ultra-Low-Alcohol PROVIOTIC 35 CAPSULES
Flavor free 100% Vegan (plant cellulose capsule) Certified organic No major allergens (lactose free, gluten
free, soy free, nuts free) No GMO No bloating (homofermentative)
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GROUP C:
Low-Alcohol Beverages 4.5% vol.
PROVIOTIC 30 TABLETS
No other ingredients (100% Pure ProViotic Tablet)
Blendable tablet (perfect for smoothies) 100% Vegan Certified organic No major allergens (lactose free, gluten
free, soy free, nuts free) No GMO No bloating (homofermentative)
18
Apple Cider Low-Alcohol 4.5% vol. PROVIOTIC TRAVEL PACK – 10 CAPSULES
Flavor free 100% Vegan (plant cellulose capsule) Certified organic No major allergens (lactose free, gluten
free, soy free, nuts free) No GMO No bloating (homofermentative)
19
PROVIOTIC FEATURED IN:
20
Pear Cider Ultra-Low-Alcohol OPRAH’S CHOICE
FEATURED IN O-MAGAZINE
21
CORE TARGET MARKET
ProViotic Product Core Target: 1) Women 20 to 65 2) Health conscious 3) Nutritious conscious – focused on organic food 4) Weight conscious 5) Focused on clean eating lifestyle 5) 6) Would not appreciate allergens in the food
22
Пробиотик
Canada: Ecotrend distributes ProViotic to over 1,000 retail stores including Whole Foods Canada.
Juice Press in Manhattan averages 14 bottles per store per week in sales – our best selling retail chain! We are in over 200
independent stores in California
In the UK we are in Planet Organic and Whole Foods
In Spain we are in over 500 independent stores.
In Austria, ProViotic is selling the in the Rauch stores. (Rauch is the largest Austrian juice manufacturer and the manufacturer of Red Bull worldwide)
In Bulgaria, we hold 20% market share.
We recently entered Switzerland
We are in 4000 CVS stores across USA
GLOBAL PROVIOTIC FOOTPRINT
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Pear Cider Ultra-Low-Alcohol ProViotic’s Multi-Spoke Marketing Strategy
Coordinates Six Strategic Programs
Multi-spoke
Marketing Strategy
In-store activities
Key Opinion Leaders
Coordination
Print Publications
Social Media Marketing
Ivy League Continuous
Research
Juice Press Cross
Marketing
Program Example of ProViotic Activity
Print Publications Featured in The Wall Street Journal, Oprah Magazine, The New Yorker, Gotham Magazine, etc.
In Store Activities Employee training, in-store booth, in store brochures, shelf-talkers
Ivy League Research Harvard Medical School findings create news opportunities. This year, we are investing $250,000 in our science program with the best Harvard researchers who will create interesting news opportunities if the scientific findings reconfirm our initial expectations.
Social Media ProViotic actively manages its Instagram and Facebook presence. We were recently featured by a prominent youtuber visiting Manhattan as a cool product in New York
Juice Press Cross Marketing ProViotic appears with Juice Press in major events such as the US Open Tennis Tournament, as well as stars such as Leonardo DiCaprio have become ProViotic consumers through Juice Press
Key Opinion Leaders ProViotic attends conferences such as the American Pediatrics Conference in Washington, where we present the advantages of ProViotic, we are also featured by some bloggers in the nutritional space
Sammi International Ltd.
+ 359 879 200 470 Tsvetomira Savova [email protected]