The Ocean Genome The Ocean Genome LegacyLegacy

Daniel L. Distel, Ph.D.,Executive Director, Ocean Genome Legacy Foundation

Goals for this presentationGoals for this presentation

• Recruit collaborators among CoML participants

• Propose a meeting to facilitate CoML collaborations

OGLOGL

OGL is a publicly supported non-profit, non-governmental organization:

• US public agencies

• Private agencies

• Corporate sponsors

• Individual donors

Richard Lounsbery Foundation Francis Goelet Charitable Lead Trust

Ocean Genome LegacyOcean Genome Legacy

Mission: to explore, preserve and protect the genetic biodiversity of the oceans

by creating a network of marine-dedicated public DNA banks

OGL HeadquartersOGL Headquarters

Center for Marine Genomic Research

Cryogenic storage facility

LaboratoriesSample processingCryogenic storageData management

DNA laboratory

Biobanking: not such a new ideaBiobanking: not such a new idea

BiobanksBiobanks

• Blood• Tissue• Reproductive products• Embryos• Tumors• Genetic materials

Biobank’s purposeBiobank’s purpose

Preserve biomaterials for future use and retrospective studies

To bring together biomaterials, data and researchers

Promote research, stimulate new ideas, and make better use of available resources.

Proven value for medical research but few repositories dedicated to natural biodiversity

Ocean Genome ResourceOcean Genome Resource

First public biological repository dedicated to preserving genomic materials from marine organisms

Directly serving the scientific community

Independent of government agencies and other private and public institutions.

Value of archived genomesValue of archived genomes

• Physiological capabilities

• Evolutionary history

• Population biology

• Ecological functions

• Species identification

• Forensic information

• Valuable Genes

How OGL worksHow OGL works

Collection & Identification

Collection & Identification

Preservation & StoragePreservation & Storage

DNA extractionDNA extraction

DistributionDistribution

Sample Submission KitSample Submission Kit

• Barcoded tubes• Sample spreadsheet• Fixative• Instructions• Shipping materials• Prepaid shipping labels

Ocean Genome ResourceOcean Genome Resource

Summary of Collection HoldingsTotal accessioned samples (as of 8/15/08)All types............................................ > 1300Number of species............................ > 200Number of phyla................................ 13Number of contributors...................... 36

OGL PartnersOGL Partners

• New England Aquarium

• Bermuda Museum of Natural History

• Philippine Marine Mollusk International Cooperative Biodiversity Group (ICBG)

Philippine Marine Mollusk ICBGPhilippine Marine Mollusk ICBG

• 5-year, $4 million project that combines• a large scale biodiversity survey• biodiversity-based drug discovery efforts

• Funded by US NIH, NSF, DOE•$250K for DNA archiving

• 5 institutions: Oregon Health Sciences UniversityUniversity of UtahUniversity of the PhilippinesAcademy of Natural Sciences, PhiladelphiaOcean Genome Legacy

• Partnership with Philippine Govt. and Institutions

SummarySummary

• OGL has developed basic methods, capabilities and policies for DNA archiving

• Seeking collaborators• specimens and taxonomic expertise • partners in efforts to gain grant support to integrate research and archival activities

• DNA archiving workshop

Finis

The ICBG ModelThe ICBG Model

Biodiversity as a source potential therapeutic compounds• supports new drug discovery• enhancing biodiversity conservation

Incentives for host nations• Economic development and building of research capacity• Formalized access and benefit sharing agreements• Intellectual property agreements prior to start of research

Workshop goalsWorkshop goals

Focus of practical considerations • Priorities for archiving• Methods development• Strategies for coordination of activities• Development of resources

OGR databaseOGR database

Results ZoneResults Zone

Location SpecimenSamples Voucher

Advanced Search

Participant …

Last Ten…

Database filters

Social Bookmarking

External Links

Taxonomically Intelligent Search Box(also can search any other database field)

Serendipity Browsinge.g., “last ten samples”, “most popular specimens”

Tabbed database results

ICBGICBG

Project title:

• Drug and energy lead compounds from Philippine mollusks

Project description:

• Biodiversity survey and conservation management plan

• Search for new drug and bioenergy compounds derived from marine mollusks and their bacterial symbionts

OGL ProgressOGL Progress

NEAq

Bermuda

ICBG

10s Fish Internal USA

100s Invertebratesmany phyla

International(permissive)

CITES

1000s Mollusks International(restrictive)

CITESand others

What is a Genome?What is a Genome?

Genome = sum of all the genetic material (DNA) in an individual cell

Contains all of the information needed to build and operate a complete living organism

Population HistoryPopulation History

Roman & Palumbi, Science. 2003 Jul 25;301(5632):451 Photo: Brandon Cole/Nature 424:479 (2003)

OGR goalsOGR goals

– Archive: to preserve and make available at cost genomic materials for future use and retrospective studies

– Forum: for sharing biomaterials, data, information, and ideas, to simulate collaboration and to make better use of available resources.

– Catalyst and Community Resource: to promote research that can protect species and environments

– For more information www.oglf.org

Who benefits?Who benefits?

Funders More productivity for research dollars

Researchers For recipients: –Easy inexpensive access validated to research materials and data

For depositors: –Safe storage

–Collaborative opportunities

– Improved funding opportunity.

States , Institutions and Public

Better science and education in support of the environment

Documentation of resources

ICBGICBG

• Margo Haygood (Lead PI): Oregon Health Sciences

• Toto Olivera & Eric Schmidt: University of Utah

• Gisselle Concepcion: University of the Philippines

• Gary Rosenburg: Academy of Natural Sciences

• Dan Distel: Ocean Genome Legacy