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TABLE OF CONTENTS Volume 6, Number 6, November 2019 Neurology.org/NN Editors Corner e630 Learning from adverse treatment eects J. Dalmau Open Access Editorials e617 Untangling normal aging from disease-related brain atrophy in MS T. Sinnecker and J. Wuerfel Open Access Companion article, p. e616 e629 Pembrolizumab as a treatment for PML? Waiting for Godot R.A. Du Pasquier Open Access Companion articles, p. e627 and e628 Articles e604 Increased frequency of anti-Ma2 encephalitis associated with immune checkpoint inhibitors A. Vogrig, M. Fouret, B. Joubert, G. Picard, V. Rogemond, A.-L. Pinto, S. MuñizCastrillo, M. Roger, J. Raimbourg, C. Dayen, L. Grignou, M. Pallix-Guyot, J. Lannoy, F. Ducray, V. Desestret, D. Psimaras, and J. Honnorat Open Access e605 HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease C. Gaig, G. Ercilla, X. Daura, M. Ezquerra, R. Fern´ andez-Santiago, E. Palou, L. Sabater, R. H¨ oftberger, A. Heidbreder, B. H¨ ogl, A. Iranzo, J. Santamaria, J. Dalmau, and F. Graus Open Access e607 Late-onset neuromyelitis optica spectrum disorder: The importance of autoantibody serostatus M. Sepulveda, G. Delgado-Garc´ ıa, Y. Blanco, N. Sola-Valls, E.H. Martinez-Lapiscina, T. Armangu´ e, C. Montejo, I. Pulido-Valdeolivas, E. Martinez-Hernandez, H. Ariño, D. Escudero, R. Ruiz-Garc´ ıa, S. Llufriu, J. Dalmau, F. Graus, and A. Saiz Open Access e609 Glutamine antagonism attenuates physical and cognitive decits in a model of MS K.R. Hollinger, M.D. Smith, L.A. Kirby, E. Prchalova, J. Alt, R. Rais, P.A. Calabresi, and B.S. Slusher Open Access e612 Neurochondrin neurological autoimmunity S. Shelly, T.J. Kryzer, L. Komorowski, R. Miske, M.D. Anderson, E.P. Flanagan, S.R. Hinson, V.A. Lennon, S.J. Pittock, and A. McKeon Open Access e614 Lymphocyte counts and infection rates: Long-term ngolimod treatment in primary progressive MS E.J. Fox, F.D. Lublin, J.S. Wolinsky, J.A. Cohen, I.M. Williams, X. Meng, M. Ziehn, S. Kolodny, and B.A.C. Cree Open Access Class of Evidence e615 Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitides: Insights from the DCVAS study A. Bischof, V.K. Jaeger, R.D.M. Hadden, R.A. Luqmani, A.-K. Pr¨ obstel, P.A. Merkel, R. Suppiah, A. Craven, M.P. Collins, and T. Daikeler Open Access e616 Contribution of normal aging to brain atrophy in MS C.J. Azevedo, S.Y. Cen, A. Jaberzadeh, L. Zheng, S.L. Hauser, and D. Pelletier Open Access Editorial, p. e617 e618 Progressive multifocal leukoencephalopathy: A 25-year retrospective cohort study P. Anand, G.C. Hotan, A. Vogel, N. Venna, and F.J. Mateen Open Access e621 Eects of natalizumab therapy on intrathecal antiviral antibody responses in MS F. Largey, I. Jelcic, M. Sospedra, C. Heesen, R. Martin, and I. Jelcic Open Access e622 Vitamin D enhances responses to interferon-β in MS X. Feng, Z. Wang, Q. Howlett-Prieto, N. Einhorn, S. Causevic, and A.T. Reder Open Access e623 Elevated levels of miR-181c and miR-633 in the CSF of patients with MS: A validation study S. Kramer, A. Haghikia, C. Bang, K. Scherf, A. Pfanne, A. Duscha, J. Kaisler, B. Gisevius, R. Gold, T. Thum, and A. Haghikia Open Access Class of Evidence Cover Image Similar microbiome proles in patients with anti-NMDAR encephalitis and control subjects. The gure shows multidimensional scaling plots of Bray-Curtis distances at genera and Operational Taxonomic Units level, demonstrating a high level of similarity regarding inter-individual dierences between anti-NMDAR encephalitis patients and healthy subjects. See page e632 Continued

The importance of autoantibody serostatusAcademy Officers JamesC.Stevens,MD,FAAN,President OrlyAvitzur, MD,MBA,FAAN,PresidentElect AnnH.Tilton,MD,FAAN,VicePresident CarlayneE.Jackson,

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Page 1: The importance of autoantibody serostatusAcademy Officers JamesC.Stevens,MD,FAAN,President OrlyAvitzur, MD,MBA,FAAN,PresidentElect AnnH.Tilton,MD,FAAN,VicePresident CarlayneE.Jackson,

TABLE OF CONTENTS Volume 6, Number 6, November 2019 Neurology.org/NN

Editor’s Corner

e630 Learning from adverse treatment effectsJ. Dalmau

Open Access

Editorials

e617 Untangling normal aging from disease-related brainatrophy in MST. Sinnecker and J. Wuerfel

Open Access Companion article, p. e616

e629 Pembrolizumab as a treatment for PML? Waitingfor GodotR.A. Du Pasquier

Open Access Companion articles, p. e627 and e628

Articles

e604 Increased frequency of anti-Ma2 encephalitisassociated with immune checkpoint inhibitorsA. Vogrig, M. Fouret, B. Joubert, G. Picard, V. Rogemond, A.-L. Pinto,S. Muñiz‐Castrillo, M. Roger, J. Raimbourg, C. Dayen, L. Grignou,M. Pallix-Guyot, J. Lannoy, F. Ducray, V. Desestret, D. Psimaras, andJ. Honnorat

Open Access

e605 HLA and microtubule-associated protein tau H1haplotype associations in anti-IgLON5 diseaseC. Gaig, G. Ercilla, X. Daura, M. Ezquerra, R. Fernandez-Santiago,E. Palou, L. Sabater, R. Hoftberger, A. Heidbreder, B. Hogl, A. Iranzo,J. Santamaria, J. Dalmau, and F. Graus

Open Access

e607 Late-onset neuromyelitis optica spectrum disorder:The importance of autoantibody serostatusM. Sepulveda, G. Delgado-Garcıa, Y. Blanco, N. Sola-Valls,E.H. Martinez-Lapiscina, T. Armangue, C. Montejo,I. Pulido-Valdeolivas, E. Martinez-Hernandez, H. Ariño, D. Escudero,R. Ruiz-Garcıa, S. Llufriu, J. Dalmau, F. Graus, and A. Saiz

Open Access

e609 Glutamine antagonism attenuates physical andcognitive deficits in a model of MSK.R. Hollinger, M.D. Smith, L.A. Kirby, E. Prchalova, J. Alt, R. Rais,P.A. Calabresi, and B.S. Slusher

Open Access

e612 Neurochondrin neurological autoimmunityS. Shelly, T.J. Kryzer, L. Komorowski, R. Miske, M.D. Anderson,E.P. Flanagan, S.R. Hinson, V.A. Lennon, S.J. Pittock, and A. McKeon

Open Access

e614 Lymphocyte counts and infection rates: Long-termfingolimod treatment in primary progressive MSE.J. Fox, F.D. Lublin, J.S. Wolinsky, J.A. Cohen, I.M. Williams, X. Meng,M. Ziehn, S. Kolodny, and B.A.C. Cree

Open Access Class of Evidence

e615 Peripheral neuropathy in antineutrophil cytoplasmicantibody-associated vasculitides: Insights from theDCVAS studyA. Bischof, V.K. Jaeger, R.D.M. Hadden, R.A. Luqmani, A.-K. Probstel,P.A. Merkel, R. Suppiah, A. Craven, M.P. Collins, and T. Daikeler

Open Access

e616 Contribution of normal aging to brain atrophy in MSC.J.Azevedo,S.Y.Cen,A. Jaberzadeh,L. Zheng,S.L.Hauser,andD.Pelletier

Open Access Editorial, p. e617

e618 Progressive multifocal leukoencephalopathy:A 25-year retrospective cohort studyP. Anand, G.C. Hotan, A. Vogel, N. Venna, and F.J. Mateen

Open Access

e621 Effects of natalizumab therapy on intrathecal antiviralantibody responses in MSF. Largey, I. Jelcic, M. Sospedra, C. Heesen, R. Martin, and I. Jelcic

Open Access

e622 Vitamin D enhances responses to interferon-β in MSX. Feng, Z. Wang, Q. Howlett-Prieto, N. Einhorn, S. Causevic, andA.T. Reder

Open Access

e623 Elevated levels ofmiR-181c andmiR-633 in theCSF ofpatients with MS: A validation studyS. Kramer, A. Haghikia, C. Bang, K. Scherf, A. Pfanne, A. Duscha,J. Kaisler, B. Gisevius, R. Gold, T. Thum, and A. Haghikia

Open Access Class of Evidence

Cover ImageSimilar microbiome profiles in patients with anti-NMDAR encephalitisand control subjects. The figure shows multidimensional scaling plotsof Bray-Curtis distances at genera and Operational Taxonomic Unitslevel, demonstrating a high level of similarity regarding inter-individualdifferences between anti-NMDAR encephalitis patients and healthysubjects.See page e632

Continued

Page 2: The importance of autoantibody serostatusAcademy Officers JamesC.Stevens,MD,FAAN,President OrlyAvitzur, MD,MBA,FAAN,PresidentElect AnnH.Tilton,MD,FAAN,VicePresident CarlayneE.Jackson,

e625 Identification of circulating MOG-specific B cells inpatients with MOG antibodiesS. Winklmeier, M. Schluter, M. Spadaro, F.S. Thaler, A. Vural,R. Gerhards, C. Macrini, S. Mader, A. Kurne, B. Inan, R. Karabudak,F.G. Ozbay, G. Esendagli, R. Hohlfeld, T. Kumpfel, and E. Meinl

Open Access

e626 Classifying the antibody-negative NMO syndromes:Clinical, imaging, and metabolomic modelingT. Yeo, F. Probert,M. Jurynczyk,M. Sealey, A. Cavey, T.D.W. Claridge,M. Woodhall, P. Waters, M.I. Leite, D.C. Anthony, and J. Palace

Open Access

e631 IL6 receptor358Ala variant and trans-signaling aredisease modifiers in amyotrophic lateral sclerosisM. Wosiski-Kuhn, M. Robinson, J. Strupe, P. Arounleut, M. Martin,J. Caress, M. Cartwright, R. Bowser, M. Cudkowicz, C. Langefeld,G.A. Hawkins, and C. Milligan

Open Access

e632 Normal gut microbiome in NMDA receptorencephalitisJ. Herken, C. Bang, M.C. Ruhlemann, C. Finke, J. Klag, A. Franke, andH. Pruss

Open Access

Clinical/Scientific Notes

e606 Steroid-sparing agents for the treatment ofinflammation in complicated neurocysticercosisP. Anand, S.S. Mukerji, J. Thon, S. Gunaratne, T.A. Cho, and N. Venna

Open Access

e608 CNS-disseminated Angiostrongylus cantonensismimicking atypical demyelinating diseaseD. Long, K. Green, T. Derani, N. Decker, R.J. Pace, and R. Aburashed

Open Access

e611 Toll-like receptor 3 deficiency in autoimmuneencephalitis post–herpes simplex encephalitisT. Armangue, B.J. Baucells, A. Vlagea,M. Petit-Pedrol, A. Esteve-Sole,A. Deya-Martınez, R. Ruiz-Garcıa, M. Juan, R. Perez de Diego,J. Dalmau, and L. Alsina

Open Access

e613 CSF orexin-A levels after rituximab treatment inrecent onset narcolepsy type 1P. Wasling, C. Malmestrom, and K. Blennow

Open Access

e619 Expanding the MOG phenotype: Brainstemencephalitis with punctate and curvilinearenhancementS. Matesanz, C. Kotch, C. Perrone, A.J. Waanders, B. Hill, andS. Narula

Open Access

e620 Overnight loss of pigmented hair in autoimmuneautonomic neuropathy treated with IVIgL.E. Turner, S.J. Pittock, M.T. McEvoy, and E.P. Flanagan

Open Access

e624 Fatal PCR-negative herpes simplex virus-1encephalitis with GABAA receptor antibodiesS. Schuster, L. Abrante, J. Matschke, M. Lutgehetmann, B. Holst,M. Gelderblom, H. Braass, F. Leypoldt, and T. Magnus

Open Access

e627 Ineffective treatment of PML with pembrolizumab:Exhausted memory T-cell subsets as a clue?M. Pawlitzki, T. Schneider-Hohendorf, L. Rolfes, S.G. Meuth,H. Wiendl, N. Schwab, and O.M. Grauer

Open Access Editorial, p. e629

e628 Pembrolizumab for progressive multifocalleukoencephalopathy due to primaryimmunodeficiencyC. Kupper, J. Heinrich, K. Kamm, V. Bucklein, S. Rothenfusser, andA. Straube

Open Access Editorial, p. e629

Views & Reviews

e610 Generation of neuroinflammation in human AfricantrypanosomiasisJ. Rodgers, I. Steiner, and P.G.E. Kennedy

Open Access

TABLE OF CONTENTS Volume 6, Number 6, November 2019 Neurology.org/NN

Page 3: The importance of autoantibody serostatusAcademy Officers JamesC.Stevens,MD,FAAN,President OrlyAvitzur, MD,MBA,FAAN,PresidentElect AnnH.Tilton,MD,FAAN,VicePresident CarlayneE.Jackson,

Academy OfficersJames C. Stevens, MD, FAAN, PresidentOrly Avitzur, MD, MBA, FAAN, President ElectAnn H. Tilton, MD, FAAN, Vice PresidentCarlayne E. Jackson, MD, FAAN, SecretaryJanis M. Miyasaki, MD, MEd, FRCPC, FAAN, TreasurerRalph L. Sacco, MD, MS, FAAN, Past President

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