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Forward looking statements
Cellibre, Inc. (“Cellibre” or the “Company”) has provided certain information set forth in this memorandum that contains “forward-looking
information”, including “future oriented financial information” and “financial outlook”, under applicable securities laws (collectively referred to
herein as forward-looking statements). Except for statements of historical fact, information contained herein constitutes forward-looking
statements and includes, but is not limited to, the (i) projected financial performance of the Company; (ii) completion of, and the use of proceeds
from, the sale of the shares being offered hereunder; (iii) the expected development of the Company’s business, projects and joint ventures; (iv)
execution of the Company’s vision and growth strategy, including with respect to future M&A activity and global growth; (v) sources and
availability of third-party financing for the Company’s projects; (vi) completion of the Company’s projects that are currently underway, in
development or otherwise under consideration; (vi) renewal of the Company’s current customer, supplier and other material agreements; and
(vii) future liquidity, working capital, and capital requirements. Forward-looking statements are provided to allow current and potential future
investors the opportunity to understand management’s beliefs and opinions in respect of the future so that they may use such beliefs and
opinions as one factor in evaluating an investment.
These statements are not guarantees of future performance and undue reliance should not be placed on them. Such forward-looking
statements necessarily involve known and unknown risks and uncertainties, which may cause actual performance and financial results in future
periods to differ materially from any projections of future performance or result expressed or implied by such forward-looking statements.
Although forward-looking statements contained in this presentation are based upon what management of the Company believes are reasonable
assumptions, there can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could
differ materially from those anticipated in such statements. The Company undertakes no obligation to update forward-looking statements if
circumstances or management’s estimates or opinions should change except as required by applicable securities laws. The reader is cautioned
not to place undue reliance on forward-looking statements
2
A track record of execution and a passion for programming life
Industry experience focused on sourcing and execution of strategic initiatives to create value and drive growth
Strategic consultant specializing in corporate strategy and financial advisory to emerging growth companies
5-year career on Wall Street advising clients in the healthcare and technology industries, executing over $6 billion in transactions across mergers and acquisitions, debt, and equity capital markets
Over 10 years of industrial leadership experience with an emphasis on challenging and complex biological problems
Led the design and engineering of one of the world’s highest volume cellular production strains
Successfully led development of multiple commercial technology packages while securing key program intellectual property
Classically trained as a bacterial geneticist with industrial experience engineering a wide range of prokaryotic and eukaryotic organisms
16 publications and 9 issued patents
Part of the initial team in two start-up companies: one developed and commercialized enzymes and one developed chemo-enzymatic routes for the synthesis of chemicals
Developed fermentation and fermentation-chemical hybrid routes for synthesis of commodity and high value chemicals
Broad scientific experience and expertise in organic chemistry, biochemistry, and protein engineering
18 publications and 12 issued patents
A career focused on strategy, resource allocation and asset monetization with a passion for building businesses
Founder of Scrypt Health and Divitempus Ventures
Board member, shareholder of American Made Systems and 83bar
Former owner and board member of ASCA Inc.
Eight-year tenure on Wall Street executing transactions with an aggregate value of over $20 billion
Ben Chiarellichief executive officer
Dr. Nicky Caiazzachief scientific officer
Scott Zingheimchief operating officer
Dr. S. Kambourakischief technology officer
3
Cellibre’s vision for a sustainable future
programming biology to make products
more sustainably, efficiently, and
reliably across industries
4
Speed to proprietary solution
Large, established,and growing market
A mission to drive the cost of cannabinoids below $100 per kilogram
$
Clear path to monetization
Cellibre to transform the supply chain
5
Monetization across a broad spectrum of evolving products
Reinventing the supply chain for markets totaling over $500 billion
6
Molecule economics allow for accelerated commercialization
$3.80 $4.75
$30-40
Nutritional protein
Omega-3 DHA oil Squalane(cosmetic)
CBD
Cost to produce ($/kg)
Market price ($/kg)
$715
Based on equity research, publicly disclosed metrics and management estimates
Example products made in bio-based production processes
Current estimated price for CBD isolate ($/kg)
$290
$50,000+
$3,000+
$80-90
We did that!
7
Today’s production is inefficient, expensive, and low-quality
Clone✓ Uniformity Foreign
contaminants
Inputs
Seed✓ Sterile Results in multiple
variants
- RFID / sophisticated tracking requirements
- Specific strains for specific extracts
Outdoor✓ Lower startup costs Arable land requirement Limited productivity Weather / pest risk
Indoor✓ Controlled✓ Enhanced productivity Capital intensive Energy intensive
- Massive water and labor requirements
- Long production cycles
Extraction
Light hydrocarbon extraction (LHC)✓ Lower capital equipment costs✓ Faster extraction cycles Extremely volatile Little control over outputs Banned in several states (BHO)
Supercritical CO2
✓ Tunable✓ Improved safety profile Capital intensive Longer extraction cycles
- Multiple downstream processing steps
- Lack of scalability
Result
Imperfect product✓ Plant-derived✓ Full / broad spectrum Impure Inconsistent Susceptible to
contaminants (chemical residue, pesticides, fungal)
Long, unpredictable production cycle from seed to product
Cultivation
8
Inputs
Reinventing the cannabinoid supply chain at scale
Cellibre cells✓ Proprietary✓ “Custom”✓ Fully characterized
Carbon + water✓ Inexpensive✓ Simple✓ Existing, efficient supply chain
Scalable✓ Water filtration and reuse✓ Semi-continuous or continuous processing✓ Fast and precise cycle times✓ Weather independent✓ Relatively low energy requirements
Quality control✓ Reproducible✓ Define inputs and outputs✓ Minimal steps to product✓ Defined, non-toxic byproducts
Pure cannabinoid✓ High-quality✓ Sustainable✓ Specific✓ Pharmaceutical-
grade Isolate forms Cultured vs. plant-
derived
Fermentation Result
9
Synthetic Agriculture Bio-industrial Cellular agriculture
Chemical production and often non-natural molecules
Product is defined on a plant by plant basis according to the unique genetic profile + growth conditions of each
Chemicals converted into cannabinoids using cell machines (enzymes) outside of a cell
Using cells as factories to convert low cost inputs directly into the product of interest via fermentation
Quality
Consistency
Resource utilization
Capital costs $$$
COGS $$$
Quality
Consistency
Resource utilization
Capital costs $$$$ ➔ $$
COGS $$$$ ➔ $$
Quality
Consistency
Resource utilization
Capital costs $$$
COGS $$$
Quality
Consistency
Resource utilization
Capital costs $$ ➔ $
COGS $
Synthetic Analogs Natural Products
[NAME] - [EMAIL] - 03/2020
Each method of cannabinoid production has unique traits
10
Glucose
Metabolism
Acetyl-CoA
GPP Olivetolic acid (OA)
CBGA
CBDATHCACBCA
FA bios
Hex-CoA
MVA
Develop strains with high flux to GPP
GPP
Hex-CoA
OA
CBGA
Engineer hexanoic acid biosynthesis form Acetyl-CoA
Develop OA producing strain
Condensing GPP and OA to produce CBG/CBGA
THCA / CBDA / CBCA
Improve expression and activity of synthetases
Derivatives production
SUGAR
THCA / CBDA / CBCA
Cell selection for an advantaged starting point
Acetyl-CoA
Engineering a cannabinoid cell factory
11
We went from napkin to foundational patent in less than eight months
NOV2019
FEB2020
SEPT2019
DEC2019
JAN2020
MARCH2020
● Closed seed round
● Moved into an empty lab space on July 15
● Full lab built with all requisite capabilities by the end of August
● Engineered selected host strain for improved production of GPP
● Completed characterization of CBGA synthases from informed search based on initial discovery data
● Successfully expressed APT73 in host strain
● Engineered lead candidate CBGA synthase variant for improved selectivity and activity
● Completed characterization of potential host strains and identified top candidate
● Completed characterization of CBGA synthases from discovery search
● Filed
foundational
patent for
novel and
advantaged
CBGA
synthases
12
CBGA formation has been the key IP battle ground for almost a decade
Glucose
Metabolism
Acetyl-CoA
GPP Olivetolic acid (OA)
CBGA
CBDATHCACBCA
FA bios
Hex-CoA
MVA
PT1
PT4
NphB
13
Significantly advantaged for the most contested area of IP
0.0x
2.0x
4.0x
6.0x
8.0x
10.0x
12.0x
14.0x
16.0x
18.0x
NphB
WT
NphB
Mutant
CLBR
APT-E
CLBR
APT-D
CLBR
APT-C
CLBR
APT-A
CLBR
APT-B
Ac
tiv
ity
re
lati
ve
to
WT
Np
hB
CBGA
Other
The top five proprietary enzymes were identified and characterized
0.0x
0.5x
1.0x
1.5x
2.0x
2.5x
3.0x
3.5x
CLBR
APT-A
CLBR
APT-A.1
CLBR
APT-A.2
Ac
tiv
ity
re
lati
ve
to
CL
BR
-AP
T-1
(W
T)
CBGA
Other
14
A dual track financing process to accelerate scientific breakthroughs
15%administrative and general corporate
purposes
64%talent (team of 14)
21%capital expenditures
and lab supplies
$3 million amend and extend on current convertible note
$10 million preferred equity raise
18%administrative and general corporate
purposes
56%Talent (growing to team
of 28 by the end of 2021)
26%capital expenditures
and lab supplies
15
● Optimized TKS and OAC
JUNE 2021
An efficient workplan accelerating the path to profitability
DEC 2020
DEC 2021
SEPT 2020
MARCH 2021
● GPP producing strain
● CBGA production strain
● CBGA lab scale launch
● Optimized fermentation conditions and DSP for CBGA
● CBGA pilot scale launch
● Cell engineering to produce hexanoic acid from glucose
● Develop an OA producing strain
SEPT 2021
● CBDA pilot scale launch
● CBGA demo scale launch
MARCH 2022
16
A better tomorrow in cannabinoid-based medicines and products
TODAY: 2,000,000 sq. ft.
TOMORROWLess than 30,000 sq. ft.
TODAY: $3k to $100k per kg
TOMORROW100s of $s per kg
TODAY: Defined by the plant
TOMORROWDefined by the brand