The DART Forum and Reception - Ionsense Inc. · Direct Analysis in Real Time Mass Spectrometry ... Feng Xu2; Yugao Wang1; Bo Chen1; Qiang Hu3; Charles C. Liu3 ... The DART Forum and

The DART Forum

American Society for Mass Spectrometry Annual Conference

May 22, 2012 Vancouver, BC

Presented by

The Annual DART Forum – May 22, 2012 Page 2

Agenda 6:45 – 7:00 AM Registration and Breakfast Buffet 7:00 – 8:15 The State of DART - Presentations Direct Analysis in Real Time Mass Spectrometry (DART-MS) Method for Glucose Quantitation Pertaining to Biofuels Production

Prof. Darrin L. Smith Eastern Kentucky University, Department of Chemistry Center for Renewable and Alternative Fuel Technologies

Rapid Screening for Pesticides Using Ambient Pressure Desorption Ionization with High-Resolution Mass Spectrometry

Dr. Sara E. Robison United States Food and Drug Administration Forensic Chemistry Center

DART-MS for the Detection of Synthetic Cannabinoids

Prof. Jason Shepard The University at Albany Department of Chemistry

Perspectives on DART Chip Cody JEOL USA

The Latest Developments in OpenSpot® and DART Technology

The IonSense Team Program Concludes 8:15 Networking 8:15 – 8:30


Direct Analysis in Real Time Mass Spectrometry (DART-MS) Method for Glucose Quantitation

Pertaining to Biofuels Production

Prof. Darrin L. Smith Eastern Kentucky University, Department of Chemistry

Center for Renewable and Alternative Fuel Technologies


Rapid Screening for Pesticides Using Ambient Pressure Desorption Ionization with High-Resolution Mass Spectrometry

Dr. Sara E. Robison United States Food and Drug Administration

Forensic Chemistry Center



DART-MS for the Detection of Synthetic Cannabinoids

Prof. Jason Shepard The University at Albany Department of Chemistry


Perspectives on DART

Chip Cody JEOL USA


The Latest Developments in OpenSpot Mass Spectrometry and DART Technology

The IonSense Team

Rapid Method Development for Emerging Threats


Fast Phthalate Non-Contact Profiling


Some Basic Questions

Do I really need an LC/MS for DART?

DART + what?

Do I need helium for DART?

What’s the DART-OS?


Selected DART Presentations and Posters

ASMS 2012

Booth 57

Booth 102

MONDAY Detection and Quantitation of Brominated and Chlorinated Hydrocarbons by DART with Linear Ion Trap and Triple Quadrupole Technology Mary Blackburn1; Scott Harrison2; Maria C. Prieto Conaway 1 1Thermo Fisher Scientific, San Jose, CA; 2AgResearch Ltd, Palmerston North, NEW ZEALAND Poster: MP21 - Environmental Analysis: General, poster number: 519, Monday, Poster Hall Molecular Imaging of Plausible Prebiotic Nucleobases by Desorption Electrospray Ionization and Laser Ablation-Direct Analysis in Real Time Mass Spectrometry. Rachel Bennett1; Joel Keelor1; Arthur Weber2; Facundo Fernandez1 1Georgia Institute of Technology, Atlanta, GA; 2SETI Institute, Mountain View, CA Poster: MP15 - Imaging MS: Small Molecules, poster number: 337, Monday, Poster Hall Rapid, Simultaneous Analysis of Organic and Inorganic Substances in Post-Detonation Radiological Debris Using Ambient Ionization Techniques and Mass Spectrometry Amanda Quinto; Tiffanie Hargraves; David Glatter; Kenyon Evans-Nguyen The University of Tampa, Tampa, FL Poster: MP23 - Forensics, poster number: 550, Monday, Poster Hall Comparative study of DESI and DART ionization sources coupled with an Orbitrap mass spectrometer for analysis of explosives on fabrics Cecile Hubert1; Xavier Machuron-Mandard1; Jean-Claude Tabet2 1CEA/DAM-IDF, Arpajon, FRANCE; 2Université Pierre et Marie Curie, Paris, France Poster: MP23 - Forensics, poster number: 554, Monday, Poster Hall Mixed-mode Nanogold Extraction Coupled with DART-MS/MS Mass Spectrometry for Forensic Toxicology Analyses Kenyon Evans-Nguyen; Jonathan Marks; Margaret Donohoe; Richard Garcia University of Tampa, Tampa, FL Poster: MP23 - Forensics, poster number: 565, Monday, Poster Hall


DART MS Analysis of Urushiol Oil (Poison Ivy) in Light Aliphatic Oil (WD-40) Causing Accidental Pediatric Allergic Contact Dermatitis (ACD) Ronny Robbins ; William Lagna; James McCarty MD; Daniel Robbins Medallion Industries, Middle River, MD Poster: MP23 - Forensics, poster number: 572, Monday, Poster Hall Field-Assisted Orthogonal Ion Injection in a Direct Analysis in Real Time (o-DART) Ionization Source for Field and Direct Ionization applications. Prabha Dwivedi1; Joel Keelor1; Paula Holmes2; Facundo Fernandez1 1Georgia Institute of Technology, Atlanta, GA; 2Photonis USA, Sturbridge, MA Poster: MP29 - Instrumentation: New Developments in Ionization and Sampling I, poster number: 684, Monday, Poster Hall TUESDAY Identification of Marker Compounds in Herbal medicines on TLC with DART-MS Minkyung Kim1; Do Hoon Kim1; In ho Kang1; Jong Hwan Kim1; Ji Yeon Kim1; Seong Ye Hyeon1; Jong Hwa Lee1; Yoon Jeong Lee1; Sun ho Kim1; Young Pyo Jang2 1National Institute of Food and Drug Safety Evaluat, Chungcheongbuk-Do, SOUTH KOREA; 2College of Pharmacy, Kyung Hee University, Seoul, South Korea Poster: TP16 - Natural Products, poster number: 307, Tuesday, Poster Hall Development of Mobile Ambient Ionization MS for Homeland Security and Defense Mitch Wells; Michael Goodwin; Michael Stump; Miriam Fico; Mark Gildersleeve; Bruce Solomon FLIR Mass Spectrometry, West Lafayette, IN Poster: TP33 - Homeland Security, poster number: 649, Tuesday, Poster Hall Quantitative Analysis of Pesticides in Juice Drinks by Direct Analysis in Real Time (DART®) Mass Spectrometry Elizabeth Crawford; Brian Musselman IonSense, Inc., Saugus, MA Poster: TP37 - Ambient Ionization: Applications I, poster number: 716, Tuesday, Poster Hall Confined DART Ion Source and Its Applications in Analysis of Volatile Organic Compounds of Citrus Limon and Allium Cepa Yue Li The University of Maryland, College Park, MD Poster: TP37 - Ambient Ionization: Applications I, poster number: 719, Tuesday, Poster Hall Evaluation of Direct Analysis in Real Time (DART) Mass Spectrometry for Rapid Identification of Adulterated Edible Oils Charles C. Liu1; Peng Wu2; Dazhou Chen3; Wei Chen4; Qiang Hu1; Lili Niu2; Tanxi Cai2; Fuquan Yang2 1ASPEC Technologies Limited, Beijing, China; 2Inst Biophysics, Chinese Academy of Sciences, Beijing, China; 3National Institute of Metrology, Beijing, China; 4Agilent Technologies, Beijing, China Poster: TP37 - Ambient Ionization: Applications I, poster number: 720, Tuesday, Poster Hall WEDNESDAY Real time lipidomic profiling using desorption ionization with ion mobility separation Jordan Krechmer2; Giorgis Isaac 1; Joseph Tice2; Kieran J Neeson1; Alan Millar1; Michael P. Balogh1; Jim Langridge1; Giuseppe Astarita1 1Waters Corporation, Milford, MA; 2IonSense, Inc., Saugus, MA Poster: WP17 - Imaging MS: Disease Markers, poster number: 372, Wednesday, Poster Hall Thermally Assisted Direct Analysis in Real Time Ionization Ion Mobility Spectrometer (IMS) Joseph Tice1; Jordan Krechmer1; Mike Festa1; Brian Musselman1; Paula Holmes2; Bruce Laprade2 1IonSense, Inc., Saugus, MA; 2Photonis USA, Inc., Sturbridge, MA


Poster: WP30 - Ion Mobility: Applications I, poster number: 641, Wednesday, Poster Hall Schlieren Imaging of Gas Fluid Dynamics at the DART Ion Source-Mass Spectrometer Interface. Matthew Curtis1; Joel Keelor2; Facundo Fernandez2; O. David Sparkman1; Patrick R. Jones1 1University of the Pacific, Stockton, CA; 2Georgia Institute of Technology, Atlanta, GA Poster: WP33 - Ambient Ionization: Fundamentals, poster number: 716, Wednesday, Poster Hall Use of a combination Direct Analysis in Real Time / Atmospheric Pressure Photoionization (APPI-DART) Ionization System for Crude Oil Analysis Brian D. Musselman 1; Jordan Krechmer1; Elizabeth Crawford1; Kaveh Jorabchi2 1IonSense, Inc., Saugus, MA; 2Syagen, Tustin, CA Poster: WP33 - Ambient Ionization: Fundamentals, poster number: 718, Wednesday, Poster Hall TLC/Plasma Assisted Multi-wavelength Laser Desorption Ionization Mass Spectrometry for Facile Separation and Selective Identification of Low Molecular Weight Compounds Jialing Zhang; Zhigui Zhou; Yu Bai; Huwei Liu College of Chemistry, Peking University, Beijing, CHINA Poster: WP34 - Ambient Ionization: Instrumentation, poster number: 737, Wednesday, Poster Hall THURSDAY Monitoring tea fermentation and manufacturing by non-targeted direct analysis in real time (DART) Karl Fraser1; Scott Harrison1; Geoff Lane1; Don Otter1; Siew-Young Quek2; Yacine Hemar2 1AgResearch Ltd, Palmerston North, NZ; 2University of Auckland, Auckland, NZ Oral: ThOD pm - Food "omics": MS Characterization of Food and Nutritional Supplements, time: 4:10, Thursday, Room 118-120 Determination of Organic Species in Lignite Using Direct Analysis in Real Time Mass Spectrometry Xing Fan 1; Xianyong Wei1; Zhimin Zong1; Feng Xu2; Yugao Wang1; Bo Chen1; Qiang Hu3; Charles C. Liu3 1China Univ of Mining and Tech, Xuzhou, CHINA; 2Pennington Biomedical Research Center, Baton Rouge, LA; 3ASPEC Technologies Limited, Beijing, CHINA Poster: ThP23 - Energy: Hydrocarbona nd Petrochemical, poster number: 499, Thursday, Poster Hall Componential analysis of pepper of various origins using DART-MS using ultra-fast polarity switching Teruhisa Shiota1; Manabu Ueda2; Tsubasa Ibushi2; Jun Watanabe2; Kazuo Mukaibatake2; Junko Iida2; Yasuhiko Bando1 1AMR, Inc., Tokyo, JAPAN; 2Shimadzu Corporation, Kyoto, JAPAN Poster: ThP25 - Instrumentation: New Developments in Ionization and Sampling III, poster number: 548, Thursday, Poster Hall High throughput molecular weight confirmation of Pharmaceutical Compounds using DART MS analysis with ultra-fast polarity switching Manabu Ueda1; Tsubasa Ibushi1; Teruhisa Shiota2; Hirotaka Honda2; Jun Watanabe1; Kazuo Mukaibatake1; Junko Iida1 1Shimadzu Corporation, Kyoto, JAPAN; 2AMR, Inc., Tokyo, JAPAN Poster: ThP25 - Instrumentation: New Developments in Ionization and Sampling III, poster number: 554, Thursday, Poster Hall Rapid Identification of Synthetic Cannabinoids in Consumer "Spice" Products John Dane 1; Ling Huang2; Mercurio Veltri2; Robert B. Cody1; Amanda Rivera2; Michael A. Marino2; Woen J. Kim3 1JEOL USA, Inc., Peabody , MA; 2Hofstra University, Hempstead, NY; 3Jericho High School, Jericho, NY Poster: ThP29 - Ambient Ionization: Applications II, poster number: 632, Thursday, Poster Hall


Direct Analysis in Real Time (DART) Mass Spectral Analysis of Ionic Liquid Media Darrin Smith1; Michael Mazzotta1; Robert Pace1; Samuel Morton III2 1Eastern Kentucky University, Richmond, KY; 2University of Kentucky, Lexington, KY Poster: ThP29 - Ambient Ionization: Applications II, poster number: 637, Thursday, Poster Hall Known-Unknowns, and Unknown-Unknowns: Ambient Ionization and Polymeric Packaging Contaminants Luke K. Ackerman1; Karim Bentayeb2; Gregory O. Noonan1; Rafael Paseiro-Cerrato 3; Timothy H. Begley1 1FDA CFSAN, College Park, MD; 2University of Zaragoza, Zaragoza, ES; 3University of Santiago de Compostela, Santiago de Compostela, ES Poster: ThP29 - Ambient Ionization: Applications II, poster number: 638, Thursday, Poster Hall Enclosed Environment for DART (Direct Analysis in Real Time)-Enabled Derivitization and Chemical Analysis Joseph LaPointe; Brian D. Musselman ; Joseph Tice; Jordan Krechmer IonSense, Inc., Saugus, MA Poster: ThP29 - Ambient Ionization: Applications II, poster number: 641, Thursday, Poster Hall H/D Exchange Combined with Direct Analysis in Real Time (DART) Mass Spectrometry and Collisional Activation for Small Molecule Structure Determination Robert B. Cody; John Dane JEOL USA, Inc., Peabody, MA Poster: ThP29 - Ambient Ionization: Applications II, poster number: 642, Thursday, Poster Hall Exploration of DART (Direct Analysis in Real Time) Mass Spectrometry for reaction monitoring and LC-MS applications in Pharmaceutical Industry Guilong (Charles) Cheng Pfizer, Inc., Groton , CT Poster: ThP29 - Ambient Ionization: Applications II, poster number: 643, Thursday, Poster Hall Identification and quantification of Geniposide in Re Du Ning Injections by DART-QTOF MS/MS Yan-Jing Li1; Zhen-Zhong Wang1; Yu-An Bi1; Gang Ding1; Long-Sheng Sheng2; Jian-Ping Qin1; Wei Xiao1; Jia-Chun Li1; Yong-Xiang Wang1; Xue Wang1 1State Key Lab of New-tech for Chinese Medicine, Lianyungang, CHINA; 2China Pharm Univeristy, Nanjing, CHINA Poster: ThP29 - Ambient Ionization: Applications II, poster number: 644, Thursday, Poster Hall Confirmatory techniques for rapid screening for pesticides using ambient pressure desorption ionization with high-resolution mass spectrometry Sara Robison1; Lorrie Lin1; Lenin Parrales1; Walter Krol2; Brian Eitzer2; Jason White2 1Food and Drug Administration, Cincinnati, OH; 2The Connecticut Agricultural Experiment Station, New Have, CT Poster: ThP29 - Ambient Ionization: Applications II, poster number: 645, Thursday, Poster Hall Rapid Screening and Identification of Traditional Chinese Medicinal Herbs Using DART-Q-TOF MS Lili Niu1; Xiaojing Guo1; Tanxi Cai1; Peng Wu1; Charles C. Liu2; Wei Chen3; Fuquan Yang1 1Institute of Biophysics, CAS, Beijing, CHINA; 2ASPEC Technologies Limited, Beijing, CHINA; 3Agilent Technologies, Beijing, CHINA Poster: ThP29 - Ambient Ionization: Applications II, poster number: 646, Thursday, Poster Hall Rapid Chemical Characterization of Glycosaminoglycans in Medical Device Materials by Ambient Mass Spectrometry Peter Nemes; Dinesh Patwardhan US FDA, Silver Spring, MD Poster: ThP29 - Ambient Ionization: Applications II, poster number: 648, Thursday, Poster Hall


Direct Analysis in Real Time (DART) Screening of the Chemical Compositions of Turmeric (Curcuma longa Linn.) Rhizome A. F. M. Motiur Rahman; Pervez Ahmad; Adnan A. Kadi King Saud University, Riyadh, SAUDI ARABIA Poster: ThP29 - Ambient Ionization: Applications II, poster number: 650, Thursday, Poster Hall Innovative methods for DART-MS enabling simultaneous identification of components in industrial products such as cream and plastic materials Haruo Shimada2; Satoru Kamikubo1; Tokimasa Kawanishi2; Yoshimasa Nakatani2; Yuka Noritake2; Rakan Matsui2; Kazumasa Kinoshita1; Yasuo Shida3 1Bio Chromato, Inc, Fujisawa-shi, Japan; 2Shiseido Research Center, Yokohama, Japan; 3University of Yamanashi, Koufu, Japan Poster: ThP29 - Ambient Ionization: Applications II, poster number: 655, Thursday, Poster Hall


DART Publications 2011-2012

2011

T. Aboul-Fadl, H. A. Abdel-Aziz, A. Kadi, P. Ahmad, T. Elsaman, M. W. Attwa, and I. A. Darwish, “Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity,” Molecules, vol. 16, no. 6, pp. 5194–5206, 2011.

J. Adams, “Analysis of printing and writing papers by using direct analysis in real time mass spectrometry,” International Journal of Mass Spectrometry, vol. 301, no. 1–3, pp. 109–126, 2011.

H. V. Botitsi, S. D. Garbis, A. Economou, and D. F. Tsipi, “Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices,” Mass Spectrom. Rev., vol. 30, no. 5, pp. 907–939, 2011.

T. Cajka, K. Riddellova, P. Zomer, H. Mol, and J. Hajslova, “Direct analysis of dithiocarbamate fungicides in fruit by ambient mass spectrometry,” Food Additives & Contaminants: Part A, vol. 28, no. 10, pp. 1372–1382, 2011.

CHENG, Xian-lon, LI ,Wen-jie, LI, Wei-jian, XIAO, Xin-yue, LIN, Rui-chao, and WEI, Feng, “Study on rapid and direct analysis of illegally added six PDE5 inhibitors in health food by DART-MS/MS method,” Chinese Journal of Pharmaceutical Analysis, vol. 31, pp. 438–442, 2011.

E. Chernetsova, P. Bochkov, G. Zatonskii, and R. Abramovich, “New approach to detecting counterfeit drugs in tablets by DART mass spectrometry,” Pharmaceutical Chemistry Journal, vol. 45, no. 5, pp. 306–308, 2011.

E. Chernetsova, M. Ovcharov, G. Zatonskii, R. Abramovich, and I. Revelskii, “Clafication of the composition of [M+18] ions in DART mass spectra of polyethylene glycol using high-resolution mass spectrometry,” Journal of Analytical Chemistry, vol. 66, no. 13, pp. 1348–1351, 2011.

E. Chernetsova and G. Morlock, “Ambient desorption ionization mass spectrometry (DART, DESI) and its bioanalytical applications,” Bioanalytical Reviews, vol. 3, no. 1, pp. 1–9, 2011.

E. S. Chernetsova, G. E. Morlock, and I. A. Revelsky, “DART mass spectrometry and its applications in chemical analysis,” Russian Chemical Reviews, vol. 80, no. 3, p. 235, 2011.

E. S. Chernetsova and G. E. Morlock, “Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry,” Mass Spectrom. Rev., vol. 30, no. 5, pp. 875–883, 2011.

D. S. Cho, S. C. Gibson, D. Bhandari, M. E. McNally, R. M. Hoffman, K. D. Cook, and L. Song, “Evaluation of direct analysis in real time mass spectrometry for onsite monitoring of batch slurry reactions,” Rapid Commun. Mass Spectrom., vol. 25, no. 23, pp. 3575–3580, 2011.

E. Crawford, J. Gordon, J.-T. Wu, B. Musselman, R. Liu, and S. Yu, “Direct analysis in real time coupled with dried spot sampling for bioanalysis in a drug-discovery setting,” Bioanalysis, vol. 3, no. 11, pp. 1217–1226, 2011.

S. E. Edison, L. A. Lin, and L. Parrales, “Practical considerations for the rapid screening for pesticides using ambient pressure desorption ionisation with high-resolution mass spectrometry,” Food Additives & Contaminants: Part A, vol. 28, no. 10, pp. 1393–1404, 2011.


S. E. Edison, L. A. Lin, B. M. Gamble, J. Wong, and K. Zhang, “Surface swabbing technique for the rapid screening for pesticides using ambient pressure desorption ionization with high-resolution mass spectrometry,” Rapid Commun. Mass Spectrom., vol. 25, no. 1, pp. 127–139, 2011.

A. H. Grange and G. W. Sovocool, “Detection of illicit drugs on surfaces using direct analysis in real time (DART) time-of-flight mass spectrometry,” Rapid Commun. Mass Spectrom., vol. 25, no. 9, pp. 1271–1281, 2011.

H. Gu, Z. Pan, B. Xi, V. Asiago, B. Musselman, and D. Raftery, “Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer,” Analytica Chimica Acta, vol. 686, no. 1–2, pp. 57–63, 2011.

J. Hajslova, T. Cajka, and L. Vaclavik, “Challenging applications offered by direct analysis in real time (DART) in food-quality and safety analysis,” TrAC Trends in Analytical Chemistry, vol. 30, no. 2, pp. 204–218, 2011.

G. A. Harris, M. Kwasnik, and F. M. Fern n dez, “Direct Analysis in Real Time Coupled to Multiple ed Drift Tube Ion Mobility Spectrometry for Detecting To ic Chemicals,” Anal. Chem., vol. 83, no. 6, pp. 1908–1915, 2011.

M. Haunschmidt, W. Buchberger, C. W. Klampfl, and R. Hertsens, “Identification and semi-quantitative analysis of parabens and UV filters in cosmetic products by direct-analysis-in-real-time mass spectrometry and gas chromatography with mass spectrometric detection,” Anal. Methods, vol. 3, no. 1, pp. 99–104, 2011.

S. E. Howlett and R. R. Steiner, “Validation of Thin Layer Chromatography with AccuTOF-DARTTM Detection for Forensic Drug Analysis*,” Journal of Forensic Sciences, vol. 56, no. 5, pp. 1261–1267, 2011.

K. Kalachova, J. Pulkrabova, L. Drabova, T. Cajka, V. Kocourek, and J. Hajslova, “Simplified and rapid determination of polychlorinated biphenyls, polybrominated diphenyl ethers, and polycyclic aromatic hydrocarbons in fish and shrimps integrated into a single method,” Analytica Chimica Acta, vol. 707, no. 1–2, pp. 84–91, 2011.

M. KAWAMURA, R. KIKURA-HANAJIRI, and Y. GODA, “Simple and Rapid Screening for Methamphetamine and 3,4-Methylene- dioxymethamphetamine (MDMA) and Their Metabolites in Urine Using Direct Analysis in Real Time (DART)-TOFMS,” YAKUGAKU ZASSHI, vol. 131, no. 5, pp. 827–833, 2011.

H. J. Kim, W. S. Baek, and Y. P. Jang, “Identification of ambiguous cubeb fruit by DART-MS-based fingerprinting combined with principal component analysis,” Food Chemistry, vol. 129, no. 3, pp. 1305–1310, 2011.

H. J. Kim, M. S. Oh, J. Hong, and Y. P. Jang, “Quantitative analysis of major dibenzocyclooctane lignans in schisandrae fructus by online TLC-DART-MS,” Phytochemical Analysis, vol. 22, no. 3, pp. 258–262, 2011.

S. Kim, H. Kim, J. Kim, Y. Kwon, M. Ahn, Y. Jang, and J. Liu, “A rapid, simple method for the genetic discrimination of intact Arabidopsis thaliana mutant seeds using metabolic profiling by direct analysis in real-time mass spectrometry,” Plant Methods, vol. 7, no. 1, p. 14, 2011.

K. Kpegba, A. Agbonon, A. G. Petrovic, E. Amouzou, M. Gbeassor, G. Proni, and N. Nesnas, “Epiafzelechin from the Root Bark of Cassia sieberiana: Detection by DART Mass Spectrometry, Spectroscopic Characterization, and Antio idant Properties,” Journal of Natural Products, vol. 74, no. 3, pp. 455–459, 2011.


R. Kubec, P. Krejc ov , P. S imek, L. V c lav k, J. Hajs lov , and J. Schraml, “Precursors and Formation of Pyrithione and Other Pyridyl-Containing Sulfur Compounds in Drumstick Onion, Allium stipitatum,” J. Agric. Food Chem., vol. 59, no. 10, pp. 5763–5770, 2011.

P. Kuc erov , R. Kubec, P. S imek, L. V c lav k, and J. Schraml, “Allium Discoloration: The Precursor and Formation of the Red Pigment in Giant Onion (Allium giganteum Regel) and Some Other Subgenus Melanocrommyum Species,” J. Agric. Food Chem., vol. 59, no. 5, pp. 1821–1828, 2011.

Á. Kuki, L. Nagy, M. Zsuga, and S. Kéki, “Fast identification of phthalic acid esters in poly(vinyl chloride) samples by Direct Analysis In Real Time (DART) tandem mass spectrometry,” International Journal of Mass Spectrometry, vol. 303, no. 2–3, pp. 225–228, 2011.

M. D. Likar, G. Cheng, N. Mahajan, and Z. Zhang, “Rapid identification and absence of drug tests for AG-013736 in 1 mg Axitinib tablets by ion mobility spectrometry and DARTTM mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 3, pp. 569–573, 2011.

A. Mess, J.-P. Vietzke, C. Rapp, and W. Francke, “Qualitative Analysis of Tackifier Resins in Pressure Sensitive Adhesives Using Direct Analysis in Real Time Time-of-Flight Mass Spectrometry,” Anal. Chem., vol. 83, no. 19, pp. 7323–7330, 2011.

A. M. Pfaff and R. R. Steiner, “Development and validation of AccuTOF-DARTTM as a screening method for analysis of bank security device and pepper spray components,” Forensic Science International, vol. 206, no. 1–3, pp. 62–70, 2011.

W. C. Samms, Y. J. Jiang, M. D. Di on, S. S. Houck, and A. Mozayani, “Analysis of Alprazolam by DART-TOF Mass Spectrometry in Counterfeit and Routine Drug Identification Cases,” Journal of Forensic Sciences, vol. 56, no. 4, pp. 993–998, 2011.

L. Vaclavik, V. Hrbek, T. Cajka, B.-A. Rohlik, P. Pipek, and J. Hajslova, “Authentication of Animal Fats Using Direct Analysis in Real Time (DART) Ionization−Mass Spectrometry and Chemometric Tools,” J. Agric. Food Chem., vol. 59, no. 11, pp. 5919–5926, 2011.

J. L. Wood and R. R. Steiner, “Purification of pharmaceutical preparations using thin-layer chromatography to obtain mass spectra with Direct Analysis in Real Time and accurate mass spectrometry,” Drug Test Analysis, vol. 3, no. 6, pp. 345–351, 2011.

J. Zhang, Z. Zhou, J. Yang, W. Zhang, Y. Bai, and H. Liu, “Thin Layer Chromatography/Plasma Assisted Multiwavelength Laser Desorption Ionization Mass Spectrometry for Facile Separation and Selective Identification of Low Molecular Weight Compounds,” Anal. Chem., vol. 84, no. 3, pp. 1496–1503, 2011.

Z. Zhou, J. Zhang, W. Zhang, Y. Bai, and H. Liu, “Rapid screening for synthetic antidiabetic drug adulteration in herbal dietary supplements using direct analysis in real time mass spectrometry,” Analyst, vol. 136, no. 12, pp. 2613–2618, 2011. 2012

R. Abramovich and I. Revel’skii, “DART mass spectrometry: rapid analysis of soft medicinal formulations,” Pharmaceutical Chemistry Journal, vol. 45, no. 11, pp. 698–700, 2012.

Y. Bai, J. Zhang, Y. Bai, and H. Liu, “Direct analysis in real time mass spectrometry combined with single-drop liquid–liquid–liquid microextraction for the rapid analysis of multiple phytohormones in fruit juice,” Analytical and Bioanalytical Chemistry, pp. 1–8, 2012.

K. Bentayeb, L. K. Ackerman, and T. H. Begley, “Ambient Ionization–Accurate Mass Spectrometry (AMI-AMS) for the Identification of Nonvisible Set-off in Food-Contact Materials,” J. Agric. Food Chem., vol. 60, no. 8, pp. 1914–1920, 2012.


E. Chernetsova, M. Bromirski, O. Scheibner, and G. Morlock, “DART-Orbitrap MS: a novel mass spectrometric approach for the identification of phenolic compounds in propolis,” Analytical and Bioanalytical Chemistry, pp. 1–9, 2012.

E. S. Chernetsova, E. A. Crawford, A. N. Shikov, O. N. Pozharitskaya, V. G. Makarov, and G. E. Morlock, “ID-CUBE direct analysis in real time high-resolution mass spectrometry and its capabilities in the identification of phenolic components from the green leaves of Bergenia crassifolia L.,” Rapid Commun. Mass Spectrom., vol. 26, no. 11, pp. 1329–1337, 2012.

E. S. Chernetsova and G. E. Morlock, “Assessing the capabilities of direct analysis in real time mass spectrometry for 5-hydro ymethylfurfural quantitation in honey,” International Journal of Mass Spectrometry, vol. 314, no. 0, pp. 22–32, 2012.

R. B. Cody, A. J. Dane, B. Dawson-Andoh, E. O. Adedipe, and K. Nkansah, “Rapid classification of White Oak (Quercus alba) and Northern Red Oak (Quercus rubra) by using pyrolysis direct analysis in real time (DARTTM) and time-of-flight mass spectrometry,” Journal of Analytical and Applied Pyrolysis, vol. 95, no. 0, pp. 134–137, 2012.

E. Crawford and B. Musselman, “Evaluating a direct swabbing method for screening pesticides on fruit and vegetable surfaces using direct analysis in real time (DART) coupled to an Exactive benchtop orbitrap mass spectrometer,” Analytical and Bioanalytical Chemistry, pp. 1–6, 2012.

H. Danhelova, J. Hradecky, S. Prinosilova, T. Cajka, K. Riddellova, L. Vaclavik, and J. Hajslova, “Rapid analysis of caffeine in various coffee samples employing direct analysis in real-time ionization–high-resolution mass spectrometry,” Analytical and Bioanalytical Chemistry, pp. 1–7, 2012.

G. Harris, C. Falcone, and F. Fern ndez, “Sensitivity ‘Hot Spots’ in the Direct Analysis in Real Time Mass Spectrometry of Nerve Agent Simulants,” Journal of The American Society for Mass Spectrometry, vol. 23, no. 1, pp. 153–161, 2012.

C. Lancaster and E. Espinoza, “Analysis of select Dalbergia and trade timber using direct analysis in real time and time-of-flight mass spectrometry for CITES enforcement,” Rapid Commun. Mass Spectrom., vol. 26, no. 9, pp. 1147–1156, 2012.

S. M. Lee, H.-J. Kim, and Y. P. Jang, “Chemometric Classification of Morphologically Similar Umbelliferae Medicinal Herbs by DART-TOF-MS Fingerprint,” Phytochem. Anal., p. n/a, 2012.

J. Lojza, T. Cajka, V. Schulzova, K. Riddellova, and J. Hajslova, “Analysis of isoflavones in soybeans employing direct analysis in real-time ionization–high-resolution mass spectrometry,” J. Sep. Science, vol. 35, no. 3, pp. 476–481, 2012.

E. Moravcova, L. Vaclavik, O. Lacina, V. Hrbek, K. Riddellova, and J. Hajslova, “Novel approaches to analysis of 3-chloropropane-1,2-diol esters in vegetable oils,” Analytical and Bioanalytical Chemistry, vol. 402, no. 9, pp. 2871–2883, 2012.

G. Morlock and E. Chernetsova, “Coupling of planar chromatography with Direct Analysis in Real Time mass spectrometry,” Central European Journal of Chemistry, vol. 10, no. 3, pp. 703–710, 2012.

R. A. Musah, R. B. Cody, A. J. Dane, A. L. Vuong, and J. R. E. Shepard, “Direct analysis in real time mass spectrometry for analysis of se ual assault evidence,” Rapid Commun. Mass Spectrom., vol. 26, no. 9, pp. 1039–1046, 2012.

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Y. Shen, T. A. van Beek, F. W. Claassen, H. Zuilhof, B. Chen, and M. W. F. Nielen, “Rapid control of Chinese star anise fruits and teas for neurotoxic anisatin by Direct Analysis in Real Time (DART) high resolution mass spectrometry,” Journal of Chromatography A, no. 0, 2012.

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