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Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases 1 of 29 Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases The country codes can be found at http://www.wipo.int/pct/guide/en/gdvol1/annexes/annexk/ax_k.pdf 9A-Carbamoyl and Thiocarbamoyl Azalides with Antimalarial Activity (WO2006/087642) Country Code Status Application Number Application Date EP Pending 06744666.6 12-Jan-2006 US Pending 11/813869 12-Jan-2006 9A-Carbamoyl-Y-Aminopropyl and 9A-Thiocarbamoyl-Y-Amonopropyl-Azalides with Antimalarial Activity (WO2006/075256) Country Code Status Application Number Application Date EP Pending 06727577.6 12-Jan-2006 US Pending 11/813868 12-Jan-2006 Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides (WO2006/085228) Country Code Status Application Number Application Date EP Pending 06727593.3 13-Jan-2006 JP Pending 2007-550878 13-Jan-2006 US Pending 11/813875 13-Jan-2006 9A-Substituted Azalides (WO2007/125414) Country Code Status Application Number Application Date AR Pending P070101893 02-May-2007 BD Pending 99/2007 03-May-2007 CL Pending 2007-1242 30-Apr-2007 EP Pending 07734526.2 01-May-2007 GCC Pending GCC/P/2007/8257 02-May-2007 JO Pending 170/2007 01-May-2007 JP Pending 2009-508539 01-May-2007 PE Pending 000544-2007/OIN 02-May-2007 PK Pending 497/2007 02-May-2007 TH Pending 0701002167 01-May-2007 TW Pending 96115520 02-May-2007 US Pending 12/299042 01-May-2007 VE Pending 874-2007-PAT 30-Apr-2007

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Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases The country codes can be found at http://www.wipo.int/pct/guide/en/gdvol1/annexes/annexk/ax_k.pdf 9A-Carbamoyl and Thiocarbamoyl Azalides with Antimalarial Activity (WO2006/087642) Country Code Status Application Number Application Date EP Pending 06744666.6 12-Jan-2006 US Pending 11/813869 12-Jan-2006

9A-Carbamoyl-Y-Aminopropyl and 9A-Thiocarbamoyl-Y-Amonopropyl-Azalides with Antimalarial Activity (WO2006/075256) Country Code Status Application Number Application Date EP Pending 06727577.6 12-Jan-2006 US Pending 11/813868 12-Jan-2006

Novel Antimalarial 9A-Carbamoyl-Aminoalkyl and 9A-Thiocarbamoyl-Aminoalkyl Azalides (WO2006/085228) Country Code Status Application Number Application Date EP Pending 06727593.3 13-Jan-2006 JP Pending 2007-550878 13-Jan-2006 US Pending 11/813875 13-Jan-2006 9A-Substituted Azalides (WO2007/125414) Country Code Status Application Number Application Date AR Pending P070101893 02-May-2007 BD Pending 99/2007 03-May-2007 CL Pending 2007-1242 30-Apr-2007 EP Pending 07734526.2 01-May-2007 GCC Pending GCC/P/2007/8257 02-May-2007 JO Pending 170/2007 01-May-2007 JP Pending 2009-508539 01-May-2007 PE Pending 000544-2007/OIN 02-May-2007 PK Pending 497/2007 02-May-2007 TH Pending 0701002167 01-May-2007 TW Pending 96115520 02-May-2007 US Pending 12/299042 01-May-2007 VE Pending 874-2007-PAT 30-Apr-2007

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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9-Deoxo-9A-Methyl-9A-Aza-9A-Homoerythromycin A Derivatives and Their Use for the Treatment of Malaria (WO2009/016142) Country Code Status Application Number Application Date AR Pending P080103267 28-Jul-2008 BD Pending 222/2008 29-Jul-2008 CL Pending 2008-2223 29-Jul-2008 GCC Pending 2008/11392 28-Jul-2008 JO Pending 337/2008 28-Jul-2008 PE Pending 001268-2008/OIN 25-Jul-2008 PK Pending 903/2008 28-Jul-2008 TH Pending 0801003915 28-Jul-2008 TW Pending 97128544 29-Jul-2008 US Pending 12/180675 28-Jul-2008 UY Pending 31.252 29-Jul-2008 VE Pending 01490 08-Jul-2008 WO Pending PCT/EP2008/059848 28-Jul-2008 Novel Heterocyclic Compounds (WO2007/138048) Country Code Status Application Number Application Date AR Pending P070102297 29-May-2007 AU Pending 2007267093 29-May-2007 BD Pending 113/2007 29-May-2007 BR Pending PI0711783-3 29-May-2007 CA Pending PCT/EP2007/055188 29-May-2007 CL Pending 2007-1534 29-May-2007 CN Pending 200780028261.2 29-May-2007 CO Pending 08-125.886 29-May-2007 CR Pending 10492 29-May-2007 DZ Pending 080769 29-May-2007 EA Pending 200870545 29-May-2007 EG Pending 1290/2008 29-May-2007 EP Pending 07729610.1 29-May-2007 GCC Pending GCC/P/2007/8407 29-May-2007 ID Pending W-00200803836 29-May-2007 IL Pending 195158 29-May-2007 IN Pending 9498/DELNP/2008 29-May-2007 JO Pending 204/2007 29-May-2007 JP Pending PCT/EP2007/055188 29-May-2007 KR Pending 10-2008-7029153 29-May-2007 MA Pending PV/31430 29-May-2007 MX Pending MX/a/2008/015291 29-May-2007 MY Pending PI20084874 29-May-2007

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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NG Pending NG/C/2008/632 29-May-2007 NO Pending 20085087 29-May-2007 NZ Pending 572698 29-May-2007 PE Pending 000667-2007/OIN 29-May-2007 PH Pending 1-2008-502433 29-May-2007 PK Pending 619/2007 29-May-2007 SG Pending PCT/EP2007/055188 29-May-2007 TH Pending 0701002661 29-May-2007 TT Pending TT/A/2008/00263 29-May-2007 TW Pending 96119056 29-May-2007 UA Pending PCT/EP2007/055188 29-May-2007 VE Pending 1136/2007-PAT 29-May-2007 VN Pending 1-2008-03195 29-May-2007 ZA Pending 2008/09385 29-May-2007 US Pending 11/754382 29-May-2007 US Pending 11/755849 31-May-2007

Novel Heterocyclic Compounds (WO2006/094799) Country Code Status Application Number Application Date EP Pending 06707486.4 02-Mar-2006 JP Pending 2007-557451 02-Mar-2006 US Pending 11/817508 02-Mar-2006 Novel Substituted Pyrimidines as Cysteine Protease Inhibitors (WO2008/052934) Country Code Status Application Number Application Date AR Pending P070104761 26-Oct-2007 BD Pending 239/2007 28-Oct-2007 CL Pending 2007-3100 26-Oct-2007 EP Pending 07847076.2 26-Oct-2007 GCC Pending 2007/9367 29-Oct-2007 JO Pending 458/2007 30-Oct-2007 PE Pending 1464-2007/OIN 26-Oct-2007 PK Pending 1246/2007 26-Oct-2007 TH Pending 0701005413 26-Oct-2007 TW Pending 96140168 26-Oct-2007 VE Pending 2314/2007-PAT 26-Oct-2007 WO Pending PCT/EP2007/061516 26-Oct-2007

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Purines as Cysteine Protease Inhibitors (WO2008/107368) Country Code Status Application Number Application Date WO Pending PCT/EP2008/052431 28-Feb-2008 Pyrrolo (3,2,1-IJ) Quinoline-4-One Derivatives for Treating Tuberculosis (WO2008/125594) Country Code Status Application Number Application Date WO Pending PCT/EP2008/054363 10-Apr-2008

Heterocyclic Compounds for the Treatment of Tuberculosis (WO2009/000745) Country Code Status Application Number Application Date WO Pending PCT/EP2008/057800 19-Jun-2008

Process for the Preparation of Anti-Malarial Drugs (WO1997/13753) Country Code Status Application Number Application Date AR Patented P960104723 11-Oct-1996 AT Patented EP0871616 11-Oct-1996 AU Patented 72910/96 11-Oct-1996 BE Patented 96934646.9 11-Oct-1996 BR Pending PI9611010-4 11-Oct-1996 CA Patented 2231633 11-Oct-1996 CH Patented 96934646.9 11-Oct-1996 CN Patented 96197564.4 11-Oct-1996 CZ Patented PV1103-98 11-Oct-1996 DE Patented EP0871616 11-Oct-1996 DK Patented 96934646.9 11-Oct-1996 EP Patented 96934646.9 11-Oct-1996 ES Patented EP0871616 11-Oct-1996 FI Patented 96934646.9 11-Oct-1996 FR Patented 96934646.9 11-Oct-1996 GB Patented 96934646.9 11-Oct-1996 GR Patented 96934646.9 11-Oct-1996 HK Patented 99101378.2 07-Apr-1999 HU Pending P9900739 11-Oct-1996 IE Patented 96934646.9 11-Oct-1996 IL Patented 124060 11-Oct-1996 IN Pending 2216/DEL/96 10-Oct-1996 IT Patented 96934646.9 11-Oct-1996 JP Patented 514719/1997 11-Oct-1996 KR Patented 702696/1998 11-Oct-1996 LU Patented 96934646.9 11-Oct-1996

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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MC Patented 96934646.9 11-Oct-1996 MX Patented 982882 11-Oct-1996 NL Patented 96934646.9 11-Oct-1996 NO Patented P981537 11-Oct-1996 NZ Patented 320209 11-Oct-1996 PH Patented 54493 11-Oct-1996 PK Pending 407/98 27-Apr-1998 PK Patented 613/96 10-Oct-1996 PL Patented P326194 11-Oct-1996 PT Patented 96934646.9 11-Oct-1996 SA Patented 97170574 20-Jan-1997 SE Patented 96934646.9 11-Oct-1996 SI Patented 96934646.9 11-Oct-1996 TR Patented 1998/00637 11-Oct-1996 TW Patented 85112489 14-Oct-1996 US Patented 09/051571 11-Oct-1996 VE Pending 1721-96 11-Oct-1996 ZA Patented 96/8550 10-Oct-1996 Process for the Preparation of Quinoline Derivatives (WO2003/093239) Country Code Status Application Number Application Date BE Patented 03725179.0 02-May-2003 DE Patented 1501802 02-May-2003 EP Patented 03725179.0 02-May-2003 ES Patented 1501802 02-May-2003 FR Patented 03725179.0 02-May-2003 GB Patented 03725179.0 02-May-2003 IT Patented 03725179.0 02-May-2003 US Patented 10/513096 02-May-2003 Sitamaquine Tosylate for the Treatment of Leishmaniasis (WO2008/043726) Country Code Status Application Number Application Date EP Pending 07821013.5 08-Oct-2007 WO Pending PCT/EP2007/060640 08-Oct-2007 Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity (WO2002/08224) Country Code Status Application Number Application Date BE Patented 01969509.7 25-Jul-2001 DE Patented 1305308 25-Jul-2001 EP Patented 01969509.7 25-Jul-2001

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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ES Patented 1305308 25-Jul-2001 FR Patented 01969509.7 25-Jul-2001 GB Patented 01969509.7 25-Jul-2001 IT Patented 01969509.7 25-Jul-2001 JP Pending 2002-514130 25-Jul-2001 US Pending 11/219148 02-Sep-2005 US Patented 10/333829 25-Jul-2001 Aminopiperidine Compounds, Process for Their Preparation, and Pharmaceutical Compositions Containing Them (WO2003/064431) Country Code Status Application Number Application Date EP Pending 03734702.8 27-Jan-2003 JP Pending 2003-564054 27-Jan-2003 US Patented 10/502234 27-Jan-2003 Aminopiperidine Derivatives (WO2003/064421) Country Code Status Application Number Application Date EP Pending 03734701.0 27-Jan-2003 JP Pending 2003-564044 27-Jan-2003 US Patented 10/502233 27-Jan-2003 Compounds (WO2004/002490) Country Code Status Application Number Application Date EP Pending 03735685.4 25-Jun-2003 JP Pending 2004-516690 25-Jun-2003 US Pending 10/518655 25-Jun-2003 Aminocyclohexene Quinolines and Their Azaisosteric Analogues with Antibacterial Activity (WO2004/014361) Country Code Status Application Number Application Date BE Patented 03784064.2 23-Jul-2003 DE Patented 1539133 23-Jul-2003 EP Patented 03784064.2 23-Jul-2003 ES Patented 1539133 23-Jul-2003 FR Patented 03784064.2 23-Jul-2003 GB Patented 03784064.2 23-Jul-2003 IT Patented 03784064.2 23-Jul-2003 JP Pending 2004-526773 23-Jul-2003

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Quinolines and Nitrogenated Derivatives Thereof And Their Use As Antibacterial Agents (WO2004/050036) Country Code Status Application Number Application Date BE Patented 03787253.8 03-Dec-2003 DE Patented 1567520 03-Dec-2003 EP Patented 03787253.8 03-Dec-2003 ES Patented 03787253.8 03-Dec-2003 FR Patented 03787253.8 03-Dec-2003 GB Patented 03787253.8 03-Dec-2003 IT Patented 1567520 03-Dec-2003 JP Pending 2004-571000 03-Dec-2003 US Patented 10/537034 03-Dec-2003 Antibacterial Agents (WO2006/081179) Country Code Status Application Number Application Date EP Pending 06733804.6 24-Jan-2006 JP Pending 2007-553157 24-Jan-2006 US Pending 11/814609 24-Jan-2006 Antibacterial Agents (WO2006/081264) Country Code Status Application Number Application Date EP Pending 06719406.8 24-Jan-2006 JP Pending 2007-553182 24-Jan-2006 US Pending 11/814610 24-Jan-2006 Antibacterial Agents (WO2006/081178) Country Code Status Application Number Application Date EP Pending 06719228.6 24-Jan-2006 JP Pending 2007-553156 24-Jan-2006 US Pending 11/814612 24-Jan-2006 Antibacterial Agents (WO2006/081182) Country Code Status Application Number Application Date EP Pending 06719234.4 24-Jan-2006 JP Pending 2007-553158 24-Jan-2006 US Pending 11/814614 24-Jan-2006

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Carbamoyloxy Derivatives of Mutilin and Their Use as Antibacterials (WO1997/25309) Country Code Status Application Number Application Date BE Patented 96944684.8 19-Dec-1996 DE Patented EP0874809 19-Dec-1996 EP Patented 96944684.8 19-Dec-1996 ES Patented EP0874809 19-Dec-1996 FR Patented 96944684.8 19-Dec-1996 GB Patented 96944684.8 19-Dec-1996 IT Patented 96944684.8 19-Dec-1996 JP Patented 524826/1997 19-Dec-1996 US Patented 09/101210 19-Dec-1996 US Patented 09/467695 21-Dec-1999

Azabicyclic Carbamoyloxy Mutilin Derivatives for Antibacterial Use (WO1998/05659) Country Code Status Application Number Application Date BE Patented 97940050.4 29-Jul-1997 DE Patented EP0934316 29-Jul-1997 EP Patented 97940050.4 29-Jul-1997 ES Patented EP0934316 29-Jul-1997 FR Patented 97940050.4 29-Jul-1997 GB Patented 97940050.4 29-Jul-1997 IT Patented 97940050.4 29-Jul-1997 JP Patented 507584/1998 29-Jul-1997 US Patented 09/230715 29-Jul-1997

Heterocyclic Mutilin Esters and Their Use as Antibacterials (WO2002/12199) Country Code Status Application Number Application Date BE Patented 01971856.8 02-Aug-2001 DE Patented 1309565 02-Aug-2001 EP Patented 01971856.8 02-Aug-2001 ES Patented 1309565 02-Aug-2001 FR Patented 01971856.8 02-Aug-2001 GB Patented 01971856.8 02-Aug-2001 IT Patented 1309565 02-Aug-2001 JP Pending 2002-518177 02-Aug-2001 US Patented 10/343596 02-Aug-2001

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Pleuromutilin Derivatives with Antimicrobial Activity (WO2002/38528) Country Code Status Application Number Application Date BE Patented 01993595.6 12-Nov-2001 DE Patented 1355873 12-Nov-2001 EP Patented 01993595.6 12-Nov-2001 ES Patented 1355873 12-Nov-2001 FR Patented 01993595.6 12-Nov-2001 GB Patented 01993595.6 12-Nov-2001 IT Patented 01993595.6 12-Nov-2001 US Patented 10/416432 12-Nov-2001

Pleuromutilin Derivatives, Process for Their Preparation and Uses Thereof (WO2004/089886) Country Code Status Application Number Application Date EP Pending 04725941.1 06-Apr-2004 JP Pending 2006-505075 06-Apr-2004 Novel Intermediates And Their Use (WO2007/062332) Country Code Status Application Number Application Date EP Pending 06839944.3 18-Nov-2006 JP Pending 2008-541494 18-Nov-2006 US Pending 12/093745 18-Nov-2006 Peptide Deformylase Inhibitors (WO2002/070653) Country Code Status Application Number Application Date US Patented 10/469515 01-Mar-2002 Peptide Deformylase Inhibitors (WO2005/005456) Country Code Status Application Number Application Date US Patented 10/563777 08-Jul-2004 Quinolines and Nitrogenated Derivative Thereof Substituted in 4-Position by a Piperidine-Containing Moiety and Their Use as Antibacterial Agents (WO2002/056882) Country Code Status Application Number Application Date BE Patented 02702296.1 22-Jan-2002 DE Patented 1359908 22-Jan-2002 EP Patented 02702296.1 22-Jan-2002 ES Patented 1359908 22-Jan-2002

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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FR Patented 02702296.1 22-Jan-2002 GB Patented 02702296.1 22-Jan-2002 IT Patented 02702296.1 22-Jan-2002 JP Pending 2002-557390 22-Jan-2002 US Patented 10/466394 22-Jan-2002 Nitrogen-Containing Bicyclic Heterocycles for Use as Antibacterials (WO2003/087098) Country Code Status Application Number Application Date BE Patented 02807202.3 24-May-2002 DE Patented 1399443 24-May-2002 EP Patented 02807202.3 24-May-2002 ES Patented 1399443 24-May-2002 FR Patented 02807202.3 24-May-2002 GB Patented 02807202.3 24-May-2002 IT Patented 02807202.3 24-May-2002 JP Pending 2003-584054 24-May-2002 US Patented 10/478154 24-May-2002 Compounds (WO2004/002992) Country Code Status Application Number Application Date EP Pending 03747857.5 25-Jun-2003 JP Pending 2004-548887 25-Jun-2003 US Pending 10/518653 25-Jun-2003 Antibacterial Agents (WO2004/041210) Country Code Status Application Number Application Date EP Pending 03783156.7 04-Nov-2003 JP Pending 2004-550496 04-Nov-2003 US Pending 10/533501 04-Nov-2003 Antibacterial Agents (WO2004/096982) Country Code Status Application Number Application Date EP Pending 03816120.4 04-Nov-2003 JP Pending 2004-571466 04-Nov-2003 US Patented 10/533502 04-Nov-2003

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Antibacterial Agents (WO2004/087145) Country Code Status Application Number Application Date EP Patented 04758428.9 26-Mar-2004 JP Pending 2006-509364 26-Mar-2004 Antibacterial Agents (WO2006/002047) Country Code Status Application Number Application Date EP Pending 05785327.7 15-Jun-2005 JP Pending 2007-516640 15-Jun-2005 US Pending 11/628705 15-Jun-2005 Antibacterial Agents (WO2006/017326) Country Code Status Application Number Application Date EP Pending 05769569.4 13-Jul-2005 JP Pending 2007-521595 13-Jul-2005 US Pending 11/570600 13-Jul-2005 Antibacterial Agents (WO2006/017468) Country Code Status Application Number Application Date EP Pending 05782987.1 02-Aug-2005 JP Pending 2007-524898 02-Aug-2005 US Pending 11/572929 02-Aug-2005 Pyrrolo-Quinoxalinone Derivatives as Antibacterials (WO2007/115947) Country Code Status Application Number Application Date EP Pending 07727528.7 29-Mar-2007 JP Pending 2009-503546 29-Mar-2007 US Pending 12/295749 29-Mar-2007 Tryclic Nitrogen Containing Compounds and Their Use as Antibacterials (WO2007/122258) Country Code Status Application Number Application Date EP Pending 07728534.4 25-Apr-2007 JP Pending 2009-507076 25-Apr-2007 US Pending 12/298326 25-Apr-2007

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Substituted 1-Methyl-1H-Quinolin-2-Ones and 1-Methyl-1H-1,5-Naphthyridin-2-Ones as Antibacterials (WO2008/006648) Country Code Status Application Number Application Date EP Pending 07819894.2 08-Jun-2007 JP Pending PCT/EP2007/055643 08-Jun-2007 US Pending 12/303997 08-Jun-2007 Azatricyclic Compounds and Their Use (WO2008/003690) Country Code Status Application Number Application Date EP Pending 07786995.6 03-Jul-2007 JP Pending PCT/EP2007/056664 03-Jul-2007 US Pending 12/305405 03-Jul-2007 Antibacterial Agents (WO2006/081289) Country Code Status Application Number Application Date EP Pending 06733883.0 24-Jan-2006 JP Pending 2007-553200 24-Jan-2006 US Patented 11/814611 24-Jan-2006 Antibacterial Agents (WO2007/118130) Country Code Status Application Number Application Date EP Pending 07760148.2 05-Apr-2007 JP Pending 2009-504471 05-Apr-2007 US Pending 12/296119 05-Apr-2007 Compounds (WO2007/081597) Country Code Status Application Number Application Date AR Pending P060104571 19-Oct-2006 AU Pending 2006335042 17-Oct-2006 BD Pending 236/2006 19-Oct-2006 BR Pending PI0617467-1 17-Oct-2006 CA Pending 2626641 17-Oct-2006 CL Pending 2006-2832 19-Oct-2006 CN Pending 200680048695.4 17-Oct-2006 CO Pending 08-040841 17-Oct-2006 CR Pending 9930 17-Oct-2006 DZ Pending 080314 17-Oct-2006 EA Pending 200801128 17-Oct-2006 EG Pending 624/2008 17-Oct-2006 EP Pending 06849235.4 17-Oct-2006

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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GCC Pending GCC/P/2006/7114 28-Oct-2006 HK Pending 08110046.5 10-Sep-2008 ID Pending W00200801273 17-Oct-2006 IL Pending PCT/US2006/060023 17-Oct-2006 IN Pending 3126/DELNP/2008 17-Oct-2006 JO Pending 378/2006 19-Oct-2006 JP Pending 2008-536625 17-Oct-2006 KR Pending 10-2008-7012082 17-Oct-2006 MA Pending PV/30851 17-Oct-2006 MT Patented 3834 20-Oct-2006 MX Pending MX/a/2008/005177 17-Oct-2006 MY Pending PI20081178 17-Oct-2006 NG Pending NG/C/2008/214 17-Oct-2006 NO Pending 20082191 17-Oct-2006 NZ Pending 567315 17-Oct-2006 PE Pending 001266-2006/OIN 19-Oct-2006 PH Pending 1-2008-500911 17-Oct-2006 PK Pending 1403/2006 19-Oct-2006 SG Pending 200802798-9 17-Oct-2006 TH Pending 0601005163 19-Oct-2006 TT Pending TT/A/2008/00071 17-Oct-2006 TW Pending 95138495 19-Oct-2006 UA Pending a200805152 17-Oct-2006 US Pending 11/550005 17-Oct-2006 US Pending 12/090947 17-Oct-2006 VE Pending 2379/2006 20-Oct-2006 VN Pending 1-2008-01204 17-Oct-2006 ZA Pending 2008/03275 17-Oct-2006 Heterocyclic Compounds, Their Preparation and Their Use as Antibacterials (WO2007/071936) Country Code Status Application Number Application Date EP Pending 06831388.1 15-Dec-2006 JP Pending 2008-546579 15-Dec-2006 US Pending 11/611214 15-Dec-2006 US Pending 12/158397 15-Dec-2006 Novel Pleuromutilin Derivatives (WO2002/30929) Country Code Status Application Number Application Date BE Patented 01986687.0 08-Oct-2001 BE Patented 05075608.9 09-Mar-2005 DE Patented 1351959 08-Oct-2001

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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DE Patented 1538150 09-Mar-2005 EP Patented 01986687.0 08-Oct-2001 EP Patented 05075608.9 09-Mar-2005 ES Patented 1351959 08-Oct-2001 ES Patented 1538150 09-Mar-2005 FR Patented 01986687.0 08-Oct-2001 FR Patented 05075608.9 09-Mar-2005 GB Patented 01986687.0 08-Oct-2001 GB Patented 05075608.9 09-Mar-2005 IT Patented 01986687.0 08-Oct-2001 IT Patented 05075608.9 09-Mar-2005 JP Patented 2002-534315 08-Oct-2001 US Patented 10/399023 08-Oct-2001 US Patented 11/004751 03-Dec-2004 2-Hydroxy-Mutilin Carbamate Derivatives for Antibacterial Use (WO2001/74788) Country Code Status Application Number Application Date EP Pending 01938069.0 29-Mar-2001 JP Pending 2001-572483 29-Mar-2001 US Patented 10/240908 29-Mar-2001

Novel Polymorph of (5-Amino-6-Methoxy-3-Pyridincarbonyl)Carbamic Acid 2-(S)-Hydroxymutilin 14-Ester (WO2006/063801) Country Code Status Application Number Application Date EP Pending 05818991.1 09-Dec-2005 US Pending 11/721465 09-Dec-2005 Polypeptide Deformylase Inhibitors (WO2001/85170) Country Code Status Application Number Application Date BE Patented 01935094.1 04-May-2001 DE Patented 1283711 04-May-2001 EP Patented 01935094.1 04-May-2001 ES Patented 1283711 04-May-2001 FR Patented 01935094.1 04-May-2001 GB Patented 01935094.1 04-May-2001 IT Patented 1283711 04-May-2001 JP Pending 2001-581824 04-May-2001 US Patented 10/275522 04-May-2001 US Patented 10/818074 05-Apr-2004

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Peptide Deformylase Inhibitors (WO2001/85160) Country Code Status Application Number Application Date BE Patented 01933082.8 04-May-2001 DE Patented 01933082.8 04-May-2001 EP Patented 01933082.8 04-May-2001 ES Patented 1283709 04-May-2001 FR Patented 01933082.8 04-May-2001 GB Patented 01933082.8 04-May-2001 IT Patented 01933082.8 04-May-2001

Peptide Deformylase Inhibitors (WO2004/098584) Country Code Status Application Number Application Date BE Patented 03719773.8 16-Apr-2003 DE Patented 03719773.8 16-Apr-2003 EP Patented 03719773.8 16-Apr-2003 ES Patented 03719773.8 16-Apr-2003 FR Patented 03719773.8 16-Apr-2003 GB Patented 03719773.8 16-Apr-2003 IT Patented 03719773.8 16-Apr-2003 JP Pending 2004-571636 16-Apr-2003 US Patented 10/553142 16-Apr-2003

Peptide Deformylase Inhibitors (WO2002/070541) Country Code Status Application Number Application Date AU Patented 2002335490 01-Mar-2002 EP Pending 02748375.9 01-Mar-2002 GCC Patented GCC/P/2002/1882 01-Mar-2002 JP Pending 2002-569860 01-Mar-2002 NG Patented 95/2002 19-Mar-2002 NZ Patented 527728 01-Mar-2002 PE Patented 000170-2002/OIN 01-Mar-2002 SG Patented 200304530-9 01-Mar-2002 US Patented 10/469433 01-Mar-2002

Peptide Deformylase Inhibitors (WO2002/070654) Country Code Status Application Number Application Date BE Patented 02725047.1 01-Mar-2002 DE Patented 1363623 01-Mar-2002 EP Patented 02725047.1 01-Mar-2002

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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ES Patented 1363623 01-Mar-2002 FR Patented 02725047.1 01-Mar-2002 GB Patented 02725047.1 01-Mar-2002 IT Patented 02725047.1 01-Mar-2002 JP Pending 2002-570682 01-Mar-2002 US Patented 10/469560 01-Mar-2002

Peptide Deformylase Inhibitors (WO2002/070540) Country Code Status Application Number Application Date BE Patented 02728382.9 01-Mar-2002 DE Patented 1370258 01-Mar-2002 EP Patented 02728382.9 01-Mar-2002 ES Patented 1370258 01-Mar-2002 FR Patented 02728382.9 01-Mar-2002 GB Patented 02728382.9 01-Mar-2002 IT Patented 02728382.9 01-Mar-2002 JP Pending 2002-569859 01-Mar-2002 US Patented 11/683089 07-Mar-2007 Peptide Deformylase Inhibitors (WO2003/002522) Country Code Status Application Number Application Date EP Pending 02770378.4 04-Apr-2002 JP Patented 2003-508705 04-Apr-2002 US Patented 10/473060 04-Apr-2002

Peptide Deformylase Inhibitors (WO2002/098901) Country Code Status Application Number Application Date EP Pending 02756123.2 04-Jun-2002 JP Pending 2003-502021 04-Jun-2002 US Patented 10/478620 04-Jun-2002

Peptide Deformylase Inhibitors (WO2003/077913) Country Code Status Application Number Application Date BR Pending PI0308321-7 12-Mar-2003 CA Pending 2478331 12-Mar-2003 CN Patented 03810650.7 12-Mar-2003 CO Pending 04090188 12-Mar-2003 EP Pending 03744644.0 12-Mar-2003 HK Pending 05104115.7 17-May-2005 IL Pending 163899 12-Mar-2003

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IN Pending 2442/DELNP/2004 12-Mar-2003 IS Pending 7441 12-Mar-2003 JP Pending 2003-575966 12-Mar-2003 KR Pending 10-2004-7014184 12-Mar-2003 MX Patented MX/A/2007/000622 16-Jan-2007 MX Patented PA/A/2004/008799 12-Mar-2003 MY Pending PI20030842 11-Mar-2003 NO Pending 20044186 12-Mar-2003 NZ Patented 534839 12-Mar-2003 PH Pending 1-2004-501387 12-Mar-2003 PK Pending 214/2003 11-Mar-2003 PL Pending P371016 12-Mar-2003 RU Patented 2004130454 12-Mar-2003 SG Patented 200404862-5 12-Mar-2003 TW Patented 92105141 11-Mar-2003 US Pending 11/675788 16-Feb-2007 VE Pending 374/2003 11-Mar-2003 ZA Patented 2004/6973 12-Mar-2003

Peptide Deformylase Inhibitors (WO2003/101442) Country Code Status Application Number Application Date AM Patented EA200401628 30-May-2003 AP Patented AP/P/2004/003156 30-May-2003 AU Pending 2003247445 30-May-2003 AZ Patented EA200401628 30-May-2003 BB Pending 2001/1098 30-May-2003 BR Pending PI0311318-3 30-May-2003 BY Patented EA200401628 30-May-2003 CA Pending 2487805 30-May-2003 CL Patented 2003-1102 29-May-2003 CO Pending 04120.065 30-May-2003 DZ Pending 040392 30-May-2003 EA Patented EA200401628 30-May-2003 EC Pending SP-04-5466 30-May-2003 EG Pending 473/2003 20-May-2003 EP Pending 03756286.5 30-May-2003 GCC Pending GCC/P/2003/2688 31-May-2003 HK Pending 05107089.2 16-Aug-2005 ID Pending W00200402945 30-May-2003 IL Pending 164973 30-May-2003 IN Patented 3241/DELNP/2004 30-May-2003 IS Pending 7610 30-May-2003

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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JP Pending 2004-508800 30-May-2003 KG Patented EA200401628 30-May-2003 KR Pending 10-2004-7019400 30-May-2003 KZ Patented EA200401628 30-May-2003 LK Pending 13517 30-May-2003 MD Patented EA200401628 30-May-2003 MX Patented PA/A/2004/011951 30-May-2003 MY Patented PI20031983 29-May-2003 NG Patented 216/2003 25-May-2003 NO Pending 20045675 30-May-2003 NZ Patented 536103 30-May-2003 OA Patented 1200400313 30-May-2003 PE Patented 00518-2003/OIN 29-May-2003 PH Pending 1-2004-501890 30-May-2003 PK Pending 480/2003 29-May-2003 PL Pending P373798 30-May-2003 RU Patented EA200401628 30-May-2003 TH Pending 082721 29-May-2003 TJ Patented EA200401628 30-May-2003 TM Patented EA200401628 30-May-2003 TW Patented 92114496 29-May-2003 UA Patented 20041109829/M 30-May-2003 US Pending 10/512926 30-May-2003 UY Pending 27.813 19-May-2003 VE Pending 878/2003 29-May-2003 VN Pending 1-2004-01383 30-May-2003 ZA Patented 2004/8315 30-May-2003

Peptide Deformylase Inhibitors (WO2004/052919) Country Code Status Application Number Application Date EP Pending 03812968.0 11-Dec-2003 JP Pending 2004-558725 11-Dec-2003 US Patented 10/538625 11-Dec-2003

Peptide Deformylase Inhibitors (WO2005/032550) Country Code Status Application Number Application Date EP Pending 03818063.4 18-Dec-2003 US Patented 10/539674 18-Dec-2003

Peptide Deformylase Inhibitors (WO2005/017124)

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Country Code Status Application Number Application Date EP Pending 04781288.8 12-Aug-2004 JP Pending 2006-523966 12-Aug-2004 US Patented 10/568026 12-Aug-2004 Novel Use (WO2006/055663) Country Code Status Application Number Application Date EP Pending 05826045.6 17-Nov-2005 JP Pending 2007-543208 17-Nov-2005 US Pending 11/718400 17-Nov-2005

Peptide Deformylase Inhibitors (WO2007/016364) Country Code Status Application Number Application Date EP Pending 06788825.5 29-Jul-2006 JP Pending 2008-524207 28-Jul-2006 US Pending 11/996994 28-Jul-2006 Derivatives and Analogs of N-Ethylquinolones and N-Ethylazaquinolones (WO2008/009700) Country Code Status Application Number Application Date AR Pending P070103200 18-Jul-2007 AU Pending 2007275188 18-Jul-2007 BD Pending 162/2007 18-Jul-2007 BR Pending PCT/EP2007/057422 18-Jul-2007 CA Pending PCT/EP2007/057422 18-Jul-2007 CL Pending 2007-2100 18-Jul-2007 CN Pending PCT/EP2007/057422 18-Jul-2007 CO Pending 09-004.535 18-Jul-2007 CR Pending 10587 18-Jul-2007 DZ Pending PCT/EP2007/057422 18-Jul-2007 EA Pending PCT/EP2007/057422 18-Jul-2007 EG Pending 71/2009 18-Jul-2007 EP Pending 07802383.5 18-Jul-2007 GCC Pending 2007/8741 21-Jul-2007 ID Pending W-00200900128 18-Jul-2007 IL Pending PCT/EP2007/057422 18-Jul-2007 IN Pending PCT/EP2007/057422 18-Jul-2007 JO Pending 293/2007 18-Jul-2007 JP Pending PCT/EP2007/057422 18-Jul-2007 KR Pending 10-2009-7003427 18-Jul-2007 MA Pending PV/31632 18-Jul-2007

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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MX Pending MX/A/2009/000797 18-Jul-2007 MY Pending PCT/EP2007/057422 18-Jul-2007 NG Pending NG/C/2008/734 18-Jul-2007 NO Pending 20090313 18-Jul-2007 NZ Pending 573644 18-Jul-2007 PE Pending 000927-2007/OIN 18-Jul-2007 PH Pending 1-2009-500092 18-Jul-2007 PK Pending 855/2007 18-Jul-2007 SG Pending PCT/EP2007/057422 18-Jul-2007 TH Pending 0701003593 18-Jul-2007 TT Pending TT/A/2009/00013 18-Jul-2007 TW Pending 96126271 19-Jul-2007 UA Pending PCT/EP2007/057422 18-Jul-2007 US Pending 12/374389 18-Jul-2007 VE Pending 01538 18-Jul-2007 VN Pending 1-2009-00354 18-Jul-2007 ZA Pending 2008/10632 18-Jul-2007 Compounds (WO2008/116815) Country Code Status Application Number Application Date WO Pending PCT/EP2008/053350 20-Mar-2008 Tricyclic Nitrogen Containing Heterocycles as Antibacterial Agents (WO2008/128953) Country Code Status Application Number Application Date WO Pending PCT/EP2008/054655 17-Apr-2008

Tricyclic Nitrogen Containing Compounds as Antibacterial Agents (WO2008/128942) Country Code Status Application Number Application Date AR Pending P080101605 18-Apr-2008 BD Pending 96/2008 20-Apr-2008 CL Pending 2008-1122 18-Apr-2008 GCC Pending 2008/10613 16-Apr-2008 JO Pending 181/2008 17-Apr-2008 PE Pending 000682-2008/OIN 18-Apr-2008 PK Pending 422/2008 18-Apr-2008 TH Pending 0801001972 18-Apr-2008 TW Pending 97114042 18-Apr-2008 UY Pending 31038 18-Apr-2008 VE Pending 708/2008 17-Apr-2008 WO Pending PCT/EP2008/054621 16-Apr-2008

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Tricyclic Compounds as Antibacterials (WO2008/128962) Country Code Status Application Number Application Date WO Pending PCT/EP2008/054667 17-Apr-2008

Compounds (WO2008/128961) Country Code Status Application Number Application Date WO Pending PCT/EP2008/054666 17-Apr-2008

Naphthoquinone Derivatives (US5175319) Country Code Status Application Number Application Date AT Patented SZ19.96 20-Aug-1996 AU Patented 2679684 13-Apr-1984 BE Patented 95C0009 29-Sep-1995 BW Patented BW.A.97.00065 13-May-1997 CH Patented CO12323801 08-Sep-1995 CY Patented 98.009 24-Sep-1998 DE Patented 19475021.3 05-Dec-1994 DK Patented CA1998.00013 24-Mar-1998 FR Patented 94C0025 16-Dec-1994 GB Patented SPCGB95004 31-Jan-1995 GI Patented 445 14-Apr-1984 HN Patented 3779 24-Aug-1990 IT Patented UB95CCP518 04-Dec-1995 LU Patented 88579 25-Jan-1995 NL Patented 950002 26-Jan-1995 SE Patented 1288669 31-Aug-1995 US Patented 07.758629 12-Sep-1991

Medicaments (US4981874) Country Code Status Application Number Application Date AP Patented APP8900136 15-Aug-1989 AT Patented 0362996 15-Aug-1989 AU Patented 3994889 15-Aug-1989 BE Patented 89308268.5 15-Aug-1989 BW Patented APP8900136 15-Aug-1989 CA Patented 608367 15-Aug-1989 CA Patented 616681 30-Jun-1993 CH Patented 89308268.5 15-Aug-1989

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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CY Patented EP 362996 15-Aug-1989 DE Patented 0362996 15-Aug-1989 DE Patented 0580185 15-Aug-1989 DK Patented 399989 15-Aug-1989 DK Patented PA200401402 15-Sep-2004 EP Patented 89308268.5 15-Aug-1989 EP Patented 93113704.6 15-Aug-1989 ES Patented 0362996 15-Aug-1989 ES Patented 93113704.6 15-Aug-1989 FR Patented 89308268.5 15-Aug-1989 FR Patented 93113704.6 15-Aug-1989 GB Patented 89308268.5 15-Aug-1989 GB Patented 93113704.6 15-Aug-1989 GH Patented APP8900136 15-Aug-1989 GM Patented APP8900136 15-Aug-1989 GR Patented 89308268.5 15-Aug-1989 HK Patented EP362996 15-Aug-1989 HU Patented 100491 15-Aug-1989 HU Patented 418889 15-Aug-1989 IE Patented 261689 15-Aug-1989 IL Pending 91308 15-Aug-1989 IL Patented 107407 26-Oct-1993 IT Patented 89308268.5 15-Aug-1989 IT Patented 93113704.6 15-Aug-1989 JE Patented EP362996 15-Aug-1989 JP Patented 21054389 15-Aug-1989 KE Patented APP8900136 15-Aug-1989 KR Patented 89-11556 14-Aug-1989 LU Patented 89308268.5 15-Aug-1989 LV Patented P.95.113 26-Apr-1995 MC Patented PV02070 16-Aug-1989 MW Patented APP8900136 15-Aug-1989 MY Patented PI8901112 15-Aug-1989 NL Patented 89308268.5 15-Aug-1989 NL Patented 93113704.6 15-Aug-1989 NZ Patented 230313 15-Aug-1989 PH Patented 39099 15-Aug-1989 PT Patented 101734 06-Jul-1995 PT Patented 91456 16-Aug-1989 SA Patented 95160138 05-Aug-1995 SD Patented APP8900136 15-Aug-1989 SE Patented 89308268.5 15-Aug-1989 SG Patented 9590420-7 15-Aug-1989 SZ Patented APP8900136 15-Aug-1989

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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TH Patented 009168 15-Aug-1989 TW Patented 78106324 15-Aug-1989 TW Patented 79110353 15-Aug-1989 UG Patented APP8900136 15-Aug-1989 US Patented 394378 15-Aug-1989 US Patented 619880 29-Nov-1990 ZA Patented 896227 15-Aug-1989 ZM Patented APP8900136 15-Aug-1989 ZW Patented APP8900136 15-Aug-1989

Medicaments (US5206268) Country Code Status Application Number Application Date US Patented 394224 15-Aug-1989 US Patented 796324 22-Nov-1991 US Patented 886028 20-May-1992

Medicaments for the Treatment of Toxoplasmosis (WO1991/04021) Country Code Status Application Number Application Date AT Patented 89912648.6 26-Oct-1989 AU Patented 4519189 26-Oct-1989 BE Patented 89912648.6 26-Oct-1989 CA Patented 2001568 26-Oct-1989 CH Patented 0445141 26-Oct-1989 DE Patented 0445141 26-Oct-1989 DK Patented 93091 26-Oct-1989 EP Patented 89912648.6 26-Oct-1989 FR Patented 89912648.6 26-Oct-1989 GB Patented 89912648.6 26-Oct-1989 IE Pending 940659 23-Aug-1994 IE Patented 345189 26-Oct-1989 IT Patented 89912648.6 26-Oct-1989 JP Patented 51168089 26-Oct-1989 LU Patented 89912648.6 26-Oct-1989 MC Patented 23133 26-Oct-1989 NL Patented 89912648.6 26-Oct-1989 SE Patented 89912648.6 26-Oct-1989 US Patented 08.466235 02-Sep-1994

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Medicament for Treatment of Protozoal Infections (WO1993/11756) Country Code Status Application Number Application Date DE Patented 0572615 17-Dec-1992 EP Patented 93900295.2 17-Dec-1992 ES Patented 0572615 17-Dec-1992 FR Patented 93900295.2 17-Dec-1992 GB Patented 93900295.2 17-Dec-1992 IT Patented 93900295.2 17-Dec-1992 US Patented 08.104034 17-Dec-1992 US Patented 08/335990 08-Nov-1994 US Patented 08.680835 16-Jul-1996

Use of 2-(4-(4-Chlorophenyl)Cyclohexyl)-3-Hydroxy-1,4-Naphthoquinone for the Treatment of Cancer (WO1994/03163) Country Code Status Application Number Application Date AU Patented 47224.93 06-Aug-1993 BE Patented 94906748.2 06-Aug-1993 DE Patented 0653936 06-Aug-1993 EP Patented 94906748.2 06-Aug-1993 ES Patented 0653936 06-Aug-1993 FR Patented 94906748.2 06-Aug-1993 GB Patented 94906748.2 06-Aug-1993 IT Patented 94906748.2 06-Aug-1993 US Patented 08.379617 06-Aug-1993 Atovaquone Pharmaceutical Compositions (WO1994/14426) Country Code Status Application Number Application Date AR Patented 327028 23-Dec-1993 AT Patented 0675711 23-Dec-1993 AU Patented 16279.97 14-Mar-1997 AU Patented 5710594 23-Dec-1993 BE Patented 94902952.4 23-Dec-1993 BG Patented 99723 23-Dec-1993 BY Patented 950492 23-Dec-1993 CA Patented 2152615 23-Dec-1993 CH Patented 94902952.4 23-Dec-1993 CN Patented 93121376.2 23-Dec-1993 CZ Patented PV145195 23-Dec-1993 DE Patented 0675711 23-Dec-1993 DK Patented 94902952.4 23-Dec-1993 EP Patented 94902952.4 23-Dec-1993

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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ES Patented 94902952.4 23-Dec-1993 FI Patented 953139 23-Dec-1993 FR Patented 94902952.4 23-Dec-1993 GB Patented 94902952.4 23-Dec-1993 GE Patented 002072 20-Dec-1993 GR Patented 94902952.4 23-Dec-1993 HK Patented 98103299.5 23-Dec-1993 HR Patented P931516A 23-Dec-1993 HU Patented P9501812 23-Dec-1993 IE Patented 94902952.4 23-Dec-1993 IL Patented 108154 23-Dec-1993 IT Patented 94902952.4 23-Dec-1993 JP Patented 51496894 23-Dec-1993 KR Patented 95702217 23-Dec-1993 KZ Patented 951649.1 23-Dec-1993 LU Patented 94902952.4 23-Dec-1993 MC Patented 94902952.4 23-Dec-1993 MX Patented 9308106 16-Dec-1993 MY Patented PI9302823 23-Dec-1993 NL Patented 94902952.4 23-Dec-1993 NO Patented P952522 23-Dec-1993 NZ Patented 258995 23-Dec-1993 PH Patented 47537 23-Dec-1993 PL Patented P309629 23-Dec-1993 PT Patented 94902952.4 23-Dec-1993 RO Patented 9501191 23-Dec-1993 RU Patented 95122758 23-Dec-1993 SA Patented 94140644 03-Apr-1994 SE Patented 94902952.4 23-Dec-1993 SG Patented 9604546.3 23-Dec-1993 SI Patented P9300678 23-Dec-1993 SK Patented PV0828.95 23-Dec-1993 TH Patented 021064 23-Dec-1993 TW Patented 82110927 23-Dec-1993 TW Patented 88101847 06-Feb-1999 UA Patented 95062971 23-Dec-1993 US Patented 08.974248 19-Nov-1997 US Patented 09.411381 04-Oct-1999 UZ Patented IHAP9500474.2 23-Dec-1993 YU Patented P808.93 22-Dec-1993 ZA Patented 939673 23-Dec-1993 Combination of Atovaquone with Proguanil for the Treatment of Protozoal Infections (WO1994/12164)

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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Country Code Status Application Number Application Date AG Patented 06/2000 28-Sep-2000 AM Patented AM96250 25-Nov-1993 AP Patented APP9300592 25-Nov-1993 AT Patented 0670719 25-Nov-1993 AU Patented 55322.94 25-Nov-1993 BE Patented 94900254.7 25-Nov-1993 BG Patented 99656 25-Nov-1993 BH Patented 207.98 17-Feb-1998 BI Patented 188/BUR 25-Nov-1993 BM Patented 218 12-Feb-2003 BN Patented GB 0670719 25-Nov-1993 BR Patented PI1100056.2 27-Sep-1996 BW Patented APP9300592 25-Nov-1993 BY Patented 950461 25-Nov-1993 CA Patented 2150234 25-Nov-1993 CD Patented NP.27.EXT.2000 31-Oct-2000 CH Patented 94900254.7 25-Nov-1993 CL Pending 2004-1554 22-Jun-2004 CN Patented 93114723.9 25-Nov-1993 CY Patented CY00.00044 25-Nov-1993 CZ Patented PV119295 25-Nov-1993 CZ Patented PV805.99 09-Mar-1999 DE Patented 0670719 25-Nov-1993 DK Patented 94900254.7 25-Nov-1993 DO Pending GB 0670719 06-Feb-1998 EC Patented SP931002 25-Nov-1993 EP Patented 94900254.7 25-Nov-1993 ES Patented 0670719 25-Nov-1993 FR Patented 94900254.7 25-Nov-1993 GB Patented 94900254.7 25-Nov-1993 GG Patented GB 0670719 25-Nov-1993 GH Patented APP9300592 25-Nov-1993 GI Patented 470 25-Nov-1993 GM Patented APP9300592 25-Nov-1993 GR Patented 94900254.7 25-Nov-1993 GY Patented 1406 07-Feb-2003 HK Patented 98103412.7 25-Nov-1993 HT Pending TBN 25-Nov-1993 HU Patented P9501537 25-Nov-1993 ID Patented P007094 25-Nov-1993 IE Patented 94900254.7 25-Nov-1993 IL Patented 107755 25-Nov-1993

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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IR Patented 38111063 08-Feb-2003 IT Patented 94900254.7 25-Nov-1993 JE Patented P643 25-Nov-1993 JP Patented 51291494 25-Nov-1993 KE Patented APP9300592 25-Nov-1993 KR Patented 10.2002.0032229 08-Jun-2002 KR Patented 95702071 25-Nov-1993 KY Patented 0670719 25-Nov-1993 KZ Patented 951632.1 25-Nov-1993 LK Patented 10818 25-Nov-1993 LS Patented APP9300592 25-Nov-1993 LU Patented 94900254.7 25-Nov-1993 MC Patented 94900254.7 25-Nov-1993 MG Patented 1395 25-Nov-1993 MW Patented APP9300592 25-Nov-1993 MX Patented 9307402 25-Nov-1993 MY Patented PI93002479 25-Nov-1993 NG Patented 28893 25-Nov-1993 NL Patented 94900254.7 25-Nov-1993 NO Patented P951995 25-Nov-1993 NZ Patented 257901 25-Nov-1993 OA Patented PV60668 25-Nov-1993 PE Patented 231837 25-Nov-1993 PH Patented 47322 25-Nov-1993 PL Patented P309222 25-Nov-1993 PT Patented 94900254.7 25-Nov-1993 RO Patented 9500963 25-Nov-1993 RU Patented 95113501.14 25-Nov-1993 SA Patented 93140434 22-Dec-1993 SC Patented 0670719 25-Nov-1993 SD Patented APP9300592 25-Nov-1993 SE Patented 94900254.7 25-Nov-1993 SG Patented 9605505.8 25-Nov-1993 SI Patented P9300614 25-Nov-1993 SK Patented PV57095 25-Nov-1993 SZ Patented APP9300592 25-Nov-1993 TCYP Patented 74 25-Nov-1993 TH Patented 020764 25-Nov-1993 TW Patented 82109940 25-Nov-1993 UA Patented 95058430 25-Nov-1993 UG Patented APP9300592 25-Nov-1993 US Patented 08.962273 31-Oct-1997 US Patented 09.409871 01-Oct-1999 US Patented 09/678485 04-Oct-2000

Current GSK patents and patent applications for small molecules and their formulations, uses and processes for neglected tropical diseases

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UZ Patented IHAP9500459.2 25-Nov-1993 VN Patented S112195 25-Nov-1993 ZA Patented 938832 25-Nov-1993 ZANZ Patented 9.2000 25-Nov-1993 ZM Patented APP9300592 25-Nov-1993 ZW Patented APP9300592 25-Nov-1993

Combination Preparation for Treating Malaria (WO2000/61133) Country Code Status Application Number Application Date AT Patented EP1171108 05-Apr-2000 AU Patented 42022.00 05-Apr-2000 BE Patented 00921746.4 05-Apr-2000 BR Pending PI0009676.8 05-Apr-2000 CH Patented 00921746.4 05-Apr-2000 CN Patented 00806064.9 05-Apr-2000 CY Patented CY03/1100784 05-Apr-2000 CZ Patented PV2001-3646 05-Apr-2000 DE Patented EP1171108 05-Apr-2000 DK Patented 00921746.4 05-Apr-2000 EP Patented 00921746.4 05-Apr-2000 ES Patented EP1171108 05-Apr-2000 FI Patented 00921746.4 05-Apr-2000 FR Patented 00921746.4 05-Apr-2000 GB Patented 00921746.4 05-Apr-2000 GR Patented EP1171108 05-Apr-2000 HK Patented 02102862.9 29-Oct-2003 HU Pending P0200842 05-Apr-2000 IE Patented 00921746.4 05-Apr-2000 IL Patented 145609 05-Apr-2000 IN Pending IN/PCT2001/00988 05-Apr-2000 IT Patented 00921746.4 05-Apr-2000 JP Pending 2000-610466 05-Apr-2000 KR Patented 10.2001.7012799 05-Apr-2000 LU Patented 00921746.4 05-Apr-2000 MC Patented 00921746.4 05-Apr-2000 MX Patented PA/a/2001/010125 05-Apr-2000 NL Patented 00921746.4 05-Apr-2000 NZ Patented 514353 05-Apr-2000 PL Pending P-350987 05-Apr-2000 PT Patented 00921746.4 05-Apr-2000 SE Patented 00921746.4 05-Apr-2000 SG Patented 200105834.6 05-Apr-2000

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SI Patented EP1171108 05-Apr-2000 TR Patented 2001.02843 05-Apr-2000 US Patented 09.958402 05-Apr-2000 ZA Patented 2001/8254 05-Apr-2000