The Anatomic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology Updated 1/2019

ACTH adrenocorticotrophic hormone AFP alpha fetoprotein AIDS acquired immunodeficiency syndrome AJCC American Joint Commission on Cancer ANA antinuclear antibody ANCA anti-neutrophil cytoplasmic autoantibody ASCO/CAP American Society of Clinical Oncology/College of American Pathologists Beta-HCG beta-human chorionic gonadotropin CBC complete blood count CK cytokeratin CLL chronic lymphocytic leukemia CMV cytomegalovirus COPD chronic obstructive pulmonary disease DCIS ductal carcinoma in situ DNA deoxyribonucleic acid EBER Epstein-Barr encoding region EBV Epstein Barr virus EGFR epidermal growth factor receptor EM electron microscopy EMA epithelial membrane antigen ER estrogen receptor EVG elastic van Gieson FISH fluorescent in-situ hybridization 5FU fluorouracil GIST gastrointestinal stromal tumor GMS Gomori methenamine silver HHV8 human herpes virus 8 HIV human immunodeficiency virus HPV human papillomavirus HSIL high grade squamous intraepithelial lesion HSV herpes simplex virus IHC immunohistochemistry INR international normalized ratio IUD intrauterine device IV intravenous LCIS lobular carcinoma in situ LSIL low grade squamous intraepithelial lesion MALT mucosa-associated lymphoid tissue NK natural killer NOS not otherwise specified NUT nuclear in testis PAS periodic acid Schiff PEComa perivascular epithelioid cell PIN prostatic intraepithelial neoplasia PLAP placental alkaline phosphatase PR progesterone receptor PSA prostate specific antigen TTF-1 thyroid transcription factor TUR transurethral resection WBC white blood cell count

WT1 Wilms tumor associated antigen Down the road, Wegener granulomatosis should be changed to granulomatosis with polyangiitis. There is no dash in “S100 protein”; PNET now Ewing sarcoma – 1/2016; Granulocytic sarcoma now myeloid sarcoma – 1/2016; 2019 - Hodgkin lymphoma – classic Hodgkin lymphoma; ALK1 – ALK; myelogenous leukemia – myeloid leukemia; SYT-SSX fusion – SS18-SSX1 fusion; IgG4-related sclerosing disease – IgG4-related disease

Updated 2/2020 The Blood Banking/Transfusion Medicine Test Development and Advisory Committee

Acceptable Abbreviations and Terminology

ACE inhibitors angiotensin converting enzyme inhibitors ADAMTS13 a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 AHF antihemophilia factor AHG antihuman globulin aPTT activated partial thromboplastin time ASFA American Society for Apheresis BMT bone marrow transplant BNP B-type natriuretic peptide CAP College of American Pathologists CBC complete blood count CD cluster designation CFR code of federal regulation CLIA Clinical Laboratory Improvements Amendments CMV cytomegalovirus CONSORT consolidated standards of reporting trials CT computerized tomography CXR chest x-ray DAT direct antiglobulin test DDAVP 1-desamino-8-D-arginine vasopressin (desmopressin) DVT deep vein thrombosis EIA enzyme immunoassay EKG electrocardiogram EPO erythropoietin FDA Food & Drug Administration FFP fresh frozen plasma G-CSF granulocyte colony stimulating factor GI gastrointestinal GVHD graft vs. host disease H1 & H2 histamine 1 & 2 HBV hepatitis B virus HCT hematocrit HCV hepatitis C virus HDFN hemolytic disease of the fetus and newborn Hb or Hgb hemoglobin HIV human immunodeficiency virus HLA human leukocyte antigen HPA human platelet antigen HPC hematopoietic progenitor cell HTLV human T-lymphotropic virus ICU intensive care unit IgG immunoglobulin G INR international normalized ratio ITP immune thrombocytopenic purpura IVIG intravenous immune globulin LDH lactate dehydrogenase LISS low ionic strength solution MRI magnetic resonance imaging NAT nucleic acid amplification test PEG polyethylene glycol

PLT platelet PO per os (by mouth) PT prothrombin time RBC red blood cell RhIG Rh immune globulin RPM revolutions per minute SBB specialist in blood banking TACO transfusion associated circulatory overload TRALI transfusion related acute lung injury TTP thrombotic thrombocytopenic purpura VWF von Willebrand factor WBC white blood cell/count Change Coombs to AHG Change Aprotinin to DDAVP Rh negative, not Rh-

Updated 3/2020 The Chemical Pathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology ACTH adrenocorticotropic hormone ADH antidiuretic hormone AFP alpha fetoprotein ALT alanine aminotransferase ANA antinuclear antibody ANCA anti-neutrophil cytoplasmic autoantibody AST aspartate aminotransferase BNP B-type natriuretic peptide C-ANCA cytoplasmic anti-neutrophil cytoplasmic autoantibody CBC complete blood count CDC Centers for Disease Control CEA carcinoembryonic antigen CK-MB creatine kinase-muscle or brain type CLIA Clinical Laboratory Improvements Amendments CLSI Clinical Laboratory Standards Institute CMS Center for Medicare and Medicaid Services CNS central nervous system CPT Current Procedural Terminology CSF cerebrospinal fluid DNA deoxyribonucleic acid DRG diagnosis related group ED emergency department EDTA ethylenediaminetetraacetic acid EKG electrocardiogram FDA Food & Drug Administration FSH follicle stimulating hormone GFR glomerular filtration rate HbX etc. hemoglobin A1c, C, D, E, S, etc. hCG human chorionic gonatotrophin HCT hematocrit HDL high density lipoprotein cholesterol HGB hemoglobin HIPAA Health Insurance Portability and Accountability Act HIV human immunodeficiency virus HLA human leukocyte antigen HPLC high performance liquid chromatography ICD-10 international classification of diseases version 10 IDL intermediate density lipoprotein cholesterol IgA etc. immunoglobulin A, D, E, G, M IL-1 etc. interleukin 1 INR international normalized ratio K2 EDTA K2 ethylenediaminetetraacetic acid LC-MS/MS liquid chromatography tandem mass spectrometry LD lactate dehydrogenase LDL low density lipoprotein cholesterol LH luteinizing hormone MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MCV mean corpuscular volume NT-ProBNP N-terminal pro-B-type natriuretic peptide

OSHA Occupational Safety and Health Administration P-ANCA perinuclear anti-neutrophil cytoplasmic autoantibody PAMG-1 placental alpha microglobulin-1 POC point of care PSA prostate specific antigen PTH parathyroid hormone RBC red blood cell rpm revolutions per minute SS-A/Ro Anti-SSA autoantibodies SS-B/La Anti-SSB autoantibodies TSH thyroid stimulating hormone VIPoma vasoactive intestinal polypeptide tumor VLDL very low density lipoprotein cholesterol WBC white blood cell Change “autoanalyzer” to “chemistry analyzer” Enzyme units are always U/L and hormones and proteins of unknown molecular weight are IU/L.

Updated 10/2020 The Cytopathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology AFB acid-fast bacilli AGC atypical glandular cells AIS adenocarcinoma in situ ALTS ASCUS/LSIL triage study ASCCP American Society for Colposcopy and Cervical Pathology ASC-H atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion ASC-US atypical squamous cell of undetermined significance ATA American Thyroid Association ATHENA addressing the need for advanced HPV diagnostics AUS/FLUS atypia of undetermined significance/follicular lesion of undetermined significance BAL bronchoalveolar lavage BCG Bacillus Calmette-Guérin BSO bilateral salpingo-oophorectomy CAIX carbonic anhydrase IX CDC Centers for Disease Control and Prevention CEA carcinoembryonic antigen CK cytokeratin CLIA Clinical Laboratory Improvement Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMS Center for Medicare and Medicaid Services CMV cytomegalovirus COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computerized tomography EBUS endobronchial ultrasound ECC endocervical curettage EMA epithelial membrane antigen ER estrogen receptor ERCP endoscopic retrograde choledochopancreatic duodenography ERG ETS (erythroblast transformation specific)-related gene EUS endoscopic ultrasound FDA Food and Drug Administration FISH fluorescent in-situ hybridization FNA fine needle aspiration FLI1 Friend leukemia integration 1 transcription factor GATA3 guanine adenine thymine adenine transcription factor 3 GFAP glial fibrillary acidic protein GIST gastrointestinal stromal tumor GMS Grocott methenamine silver HCC hepatocellular carcinoma Hep Par-1 hepatocyte paraffin-1 hpf high power field HPV human papilloma virus HSIL high grade squamous intraepithelial lesion HSV herpes simplex virus Continued on next page

IHC immunohistochemistry INR international normalized ratio INSM1 insulinoma-associated protein 1 IPMN intraductal papillary mucinous neoplasm ISH in-situ hybridization LCA leukocyte common antigen LDH lactate dehydrogenase LEEP loop electrocautery excision procedure LEF1 lymphoid enhancer binding factor 1 LSIL low grade squamous intraepithelial lesion LMP last menstrual period MALT mucosa associated lymphoid tissue MASC mammillary analogue secretory carcinoma MEN multiple endocrine neoplasia MYB V-Myb Avian Myeloblastosis Viral Oncogene Homolog N/C ratio nuclear cytoplasmic ratio NF neurofibromatosis NGS next generation sequencing NIFTP non-invasive follicular thyroid neoplasm with papillary-like nuclear features NILM negative for intraepithelial lesion or malignancy NK natural killer OSHA Occupational Safety and Health Administration panCK pancytokeratin panNET pancreatic neuroendocrine tumor PAS periodic acid Schiff PET positron emission tomography PLAG1 pleomorphic adenoma gene 1 PLAP placental alkaline phosphatase PNET primitive neuroectodermal tumor PR progesterone receptor PSA prostate specific antigen PSMA prostate specific membrane antigen PTAH phosphotungstic acid hematoxylin PTH parathormone RCC renal cell carcinoma (where appropriate) ROSE rapid onsite evaluation RPMI Roswell Park Memorial Institute medium SMA smooth muscle actin SSTR2A somatostatin receptor 2A TAH total abdominal hysterectomy TB tuberculosis TJC The Joint Commission TTF1 thyroid transcription factor 1 VHL Von Hippel-Lindau Pap test – should be - liquid-based cervical cytology (don’t summarily change old questions). Anal Pap – should be - liquid-based anal cytology. For Pap/GYN/anal/urine screening questions, the stem should read “What is the best interpretation (not dx)?”. Diagnostic cytology the stem should read “What is the most likely diagnosis?”. All GYN questions that have “recommended follow-up” should include “most recent ASCCP guidelines”. 2007 NCI Thyroid Conference = National Cancer Institute Thyroid FNA State of the Science Conf. Continued on next page

This is now changed to “The Bethesda System for Reporting Thyroid Cytopathology”. MFH – now – pleomorphic undifferentiated sarcoma. Metastatic goblet cell carcinoid tumor – now- metastatic mixed adenoneuroendocrine carcinoma. When appropriate, answer order should be: unsatisfactory, benign, atypical, suspicious, and malignant – not alpha. Virtual slides should be FNAs, not scrapes. Avoid SurePath for virtual microscopy. New term – secretory carcinoma (MASC – mammillary analogue secretory carcinoma). Per 2019 TDAC, change terminology from “32-year-old HIV positive male/female” to “32-year-old male/female living with HIV”.

Updated 9/2020 The Dermatopathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology AGEP acute generalized exanthematous pustulosis AJCC American Joint Commission on Cancer CAP College of American Pathologists CD cluster designation CK cytokeratin CLIA Clinical Laboratory Improvements Amendments CMV cytomegalovirus CPT current procedural terminology DNA deoxyribonucleic acid EBV Epstein-Barr virus EMA epithelial membrane antigen ERG erythroblast transformation-specific [ETS]-related gene FDA Food & Drug Administration FISH fluorescent in-situ hybridization GCDFP gross cystic disease fluid protein GFAP glial fibrillary acidic protein HHV human herpes virus HPV human papillomavirus HSV herpes simplex virus IgA immunoglobulin A IgD immunoglobulin D IgE immunoglobulin E IgG immunoglobulin G IgM immunoglobulin M ILVEN inflammatory linear verrucous epidermal nevus LEOPARD lentigines, EKG abnormality, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retarded growth, deafness (congenital syndrome) MiTF microphthalmia transcription factor MUM-1 multiple myeloma oncogene 1 MYC myelocytomatosis NF neurofibromatosis PAS periodic acid Schiff PEComa perivascular epithelioid cell PLEVA pityriasis lichenoides et variolaformis acuta SMA smooth muscle actin TNF- tumor necrosis factor alpha VZV varicella zoster virus “follicular lymphoma” not “follicle cell lymphoma” according to WHO Hailey-Hailey disease is now benign familial pemphigus

Updated 5/2019 The Forensic Pathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology 25I-NBOMe derivative of the phenethylamine hallucinogen 2C-I (N-bomb, Smiles, 25I, 25C, 25B) ACLS advanced cardiovascular life support ACTH adrenocorticotrophic hormone AIDS acquired immune deficiency syndrome AV atrioventricular AVM arteriovenous malformation CMV cytomegalovirus CPR cardiopulmonary resuscitation CT computed tomography D-MORT Disaster Mortuary Operational Response Teams ED emergency department EDTA ethylenediaminetetraacetic acid EEG electroencephalogram EKG electrocardiogram EPA environmental protection agency HACEK Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella HBV hepatitis B virus Hib Haemophilus influenzae, serotype b HIPAA Health Insurance Portability and Accountability Act HPV human papilloma virus IHC immunohistochemical IVDA intravenous drug abuser MDMA methylenedioxymethamphetamine (Ecstacy) MRI magnetic resonance imaging MVC motor vehicle collision NAME National Association of Medical Examiners NYCLAD nylon clad bullet OSHA Occupational Safety and Health Administration OTC over the counter PTSD post-traumatic stress disorder THC Tetrahydrocannabinol TORCH (T)oxoplasmosis, (O)ther agents, (R)ubella, (C)ytomegalovirus, and (H)erpes simplex “TASER” should be changed to electronic control device. Use “dead” not “deceased”.

The Hematopathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology - Updated 1/2020

ADP adenosine diphosphate ALK anaplastic lymphoma kinase ALL acute lymphoblastic leukemia AML acute myeloid leukemia aPTT activated partial thromboplastin time ATP adenosine triphosphate BAP break-apart CAE chloroacetate esterase CAP College of American Pathologists CBC complete blood count CLIA Clinical Laboratory Improvements Amendments CLL chronic lymphocytic leukemia CLL/SLL chronic lymphocytic leukemia/small lymphocytic leukemia CML chronic myelogenous leukemia CMML chronic myelomonocytic leukemia CMV cytomegalovirus CNS central nervous system CSF cerebrospinal fluid DIC disseminated intravascular coagulation DNMT3A DNA methyltransferase 3 alpha DLBCL diffuse large B-cell lymphoma DRVVT dilute Russell viper venom time DVT deep vein thrombosis EBER EBV-encoded RNA EBV Epstein-Barr virus ED emergency department EDTA ethylenediaminetetraacetic acid ELISA elisa assay EMA epithelial membrane antigen FDA Food & Drug Administration FISH fluorescence in-situ hybridization G-6-PD glucose-6-phosphate dehydrogenase GMS Gomori methenamine silver Hb or Hgb hemoglobin HHV8 human herpesvirus 8 HIV human immunodeficiency virus HPLC high-performance liquid chromatography IHC immunohistochemistry INR international normalized ratio ISI international sensitivity index MALT lymphoma mucosa-associated lymphoid tissue lymphoma MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDS myelodysplastic syndrome MDS/MPN myelodysplastic/myeloproliferative neoplasms MGUS monoclonal gammopathy of undetermined significance Continued on next page

MLL (KMT2A) mixed lineage leukemia MPN myeloproliferative neoplasms MPO myeloperoxidase MRD minimal residual disease NGS next generation sequencing NOS not otherwise specified NPM1 nucleophosmin gene NSE nonspecific esterase PAS periodic acid Schiff PCR polymerase chain reaction PMF primary myelofibrosis PNH paroxysmal nocturnal hemoglobinuria POEMS polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes Ph’ chromosome Philadelphia chromosome Plt platelet PT/INR prothrombin time/international normalized ratio PTLD post-transplant lymphoproliferative disorders QC quality control RAEB refractory anemia with excess blasts RARS refractory anemia with ring sideroblasts RBC red blood cell RDW red cell distribution width RNA ribonucleic acid RT-PCR reverse transcriptase polymerase chain reaction SLL small lymphocytic lymphoma SNP single nucleotide polymorphism TCR T cell receptor TdT terminal deoxynucleotidyl transferase TEMPI telangiectasias, erythrocytosis, elevated erythropoietin, monoclonal gammopathy of unknown significance, perinephric fluid, and intrapulmonary shunt TIA1 T cell intracellular antigen 1 TIBC total iron binding capacity VWF von Willebrand factor WBC white blood cell Terminology changes: MUM1 – IRF4/MUM1; indeterminate cell histiocytosis – indeterminate dendritic cell tumor; interdigitating dendritic cell tumor – interdigitating dendritic cell sarcoma Refractory anemia changed to myelodysplastic syndrome when used as a diagnosis. If refractory anemia is used in the clinical history, leave as is.

Updated 11/2020

The Management and Informatics Test Development and Advisory Committee Acceptable Abbreviations and Terminology

ABN advanced beneficiary notice ACGME Accreditation Council for Graduate Medical Education ACO accountable care organization AMR analytical measurement range aPTT activated partial thromboplastin time ASAP as soon as possible ASCII American Standard Code for Information Interchange CAP College of American Pathologists CBC complete blood count CDC Centers for Disease Control CLIA Clinical Laboratory Improvements Amendments CMS Centers for Medicare/Medicaid CPOE computerized provider order entry CPT Current Procedural Terminology PCU central processing unit CSF cerebrospinal fluid CV coefficient of variation DICOM Digital Imaging and Communications in Medicine EHR electronic health record ER estrogen receptor FDA Food and Drug Administration FTE full-time equivalent H & E hematoxylin and eosin HHS Health & Human Services HIPAA Health Insurance Portability and Accountability Act HIS hospital information system HL7 Health Level 7 HMO health maintenance organization HPV human papillomavirus HTML hypertext markup language HTTP hypertext transfer protocol ICD International Classification of Diseases IHC immunohistochemistry INR international normalized ratio IQCP individualized quality control plan IRB institutional review board ISBT 128 international standard based on the Code 128 Barcode for the transfer of information associated with blood transfusion, cellular therapy and tissue transplantation IT information technology JPEG joint photographic experts group LIS laboratory information system LOINC Logical Observation Identifiers Names and Codes MCV mean corpuscular volume OSHA Occupational Safety and Health Administration PDF portable document format PHI protected health information PR progesterone receptor PT proficiency testing (in context)

QA quality assurance QC quality control RFP request for proposal RBC red blood cells ROC receiver operator curve SD standard deviation SNOMED Systemized Nomenclature of Medicine STAT from the Latin word statum, meaning 'immediately' SWOT strengths, weaknesses, opportunities, threats TAT turn-around time TIFF Tagged Image File Format VPN virtual private network WBC white blood cells Per the 2017 TDAC, it is now back to The Joint Commission. Per the 2014 TDAC, TJC will no longer be used as an abbreviation for The Joint Commission. It will be referred to as Joint Commission, with no abbreviation. Per the 2019 TDAC, EMR is now EHR and an item bank change will be made.

Updated 3/2020 The Medical Microbiology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology

ADH arginine dihydrolase (SS only) AFB acid-fast bacilli AIDS acquired immunodeficiency syndrome AML acute myeloid leukemia ARDS acute respiratory distress syndrome BAL bronchoalveolar lavage BCYE buffered charcoal yeast extract BSL biosafety level CAMP Christie-Atkins-Munch-Petersen test CLSI Clinical Lab Standards Institute CMV cytomegalovirus CNA colistin nalidixic acid CNS central nervous system COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computed tomography DFA direct fluorescent antibody DNA deoxyribonucleic acid EBV Epstein-Barr virus EIA enzyme immunoassay ELISA enzyme-linked immunosorbent assay ESBL extended spectrum beta-lactamase G6PD glucose-6-phosphate dehydrogenase deficiency GMS Gomori (or Grocott) methenamine silver H & E hematoxylin & eosin HAART highly active antiretroviral therapy HBV hepatitis B virus HHV human herpes virus HIV human immunodeficiency virus HSV herpes simplex virus IgA etc. immunoglobulin A, D, E, G, M IGRA interferon gamma release assay LDC lysine decarboxylase test (SS only) MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MIC minimal inhibitory concentration MRI magnetic resonance imaging MRSA methicillin-resistant Staphylococcus aureus NAAT nucleic acid amplification test NGS next generation sequencing NIST National Institute of Standards and Technology ODC ornithine decarboxylase ONPG 2-nitropheynyl-β-D-galactopyranoside PAS periodic acid Schiff PCR polymerase chain reaction PPD purified protein derivative PYR pyrrolidonyl amidase reactivity RNA ribonucleic acid RPR rapid plasma reagin RSV respiratory syncytial virus

SBA sheep blood agar (SS only) TCBS agar thiosulfate-citrate-bile salts-sucrose agar TPPA treponema pallidum agglutination assay TSI triple sugar iron UTI urinary tract infection VDRL venereal disease research laboratory test VZV varicella zoster virus WBC white blood cell WHO World Health Organization When referring to the Gram stain, it should be capitalized. When referring to the gram reactivity of an organism, gram-negative or gram-positive, it is not capitalized. When writing a “sp.” or “spp.”, the entire name is not italicized.

Updated 11/2020

The Molecular Genetic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology

aCGH array comparative genomic hybridization ACMG American College of Medical Genetics and Genomics AFP alpha fetoprotein ALL acute lymphoblastic leukemia AML acute myeloid leukemia BAC baculovirus array CAP College of American Pathologists CBC complete blood count CLIA Clinical Laboratory Improvement Amendment CLL chronic lymphocytic leukemia CML chronic myeloid leukemia CMV cytomegalovirus CNV copy number variant CpG CpG (?) islands CPT current procedural terminology CSF cerebrospinal fluid CT computed tomography CT or Ct cycle threshold ctDNA circulating tumor DNA ddPCR digital droplet PCR DNA deoxyribonucleic acid EBV Epstein-Barr virus ES exome sequencing FDA Food and Drug Administration FFPE formalin fixed paraffin embedded FISH fluorescent in-situ hybridization GIST gastrointestinal stromal tumor GS genome sequencing HbF hemoglobin F HbS hemoglobin S HBV hepatitis B virus HCV hepatitis C virus HGVS Human Genome Variation Society HIV human immunodeficiency virus HPV human papillomavirus HSV herpes simplex virus IGH immunoglobulin heavy chain IGV integrative genomics viewer IHC immunohistochemical IS international scale ITD internal tandem duplication LOH loss of heterozygosity MCV mean corpuscular volume MDS myelodysplastic syndrome MEN multiple endocrine neoplasia miRNA micro-RNA MLPA multiplex ligation-dependent probe amplification

MPN myeloproliferative neoplasm MRI magnetic resonance imaging MSI microsatellite instability NGS next generation sequencing NIPS noninvasive prenatal screening NSCLC non-small cell lung cancer PCR polymerase chain reaction qPCR quantitative PCR RFLP restriction fragment length polymorphism RNA ribonucleic acid RR reference range rRNA ribosomal ribonucleic acid RT-PCR reverse transcription polymerase chain reaction SNP single nucleotide polymorphism STR short tandem repeat TKD tyrosine kinase domain Tm melting temperature TMB tumor mutational burden • Translocation genetic nomenclature rules. • For translocations, fusion genes (producing a fusion protein) are written with a hyphen between the two

genes, e.g., BCR-ABL1. • Translocations that result in gene deregulation, without producing a fusion protein, are designated with a

slash between the partner genes, e.g., IGH/MYC. The gene that provides the promoter or regulatory region is designated first, e.g., IGH/MYC, rather than MYC/IGH.

• ABL is now ABL1. • Next generation sequencing “NGS” (not high-throughput or massively parallel). • Chromosomal microarray, not chromosome microarray. • For all proteins, add “p.” after the gene; ex. BRAF p.V600E • The word “whole” has been removed from “whole exome sequencing data”, now just “exome sequencing

data”. • “Chronic myelogenous leukemia” in now “chronic myeloid leukemia”. • Use three letter codes for amino acids (instead of one letter codes). • Terminology: change “mutation” to “pathologic variant” when talking about inherited conditions,

including specific inherited forms of cancers, not other cancers.

Updated 3/2019 The Neuropathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology ACTH adrenocorticotropic hormone AIDS acquired immune deficiency syndrome ALS amyotrophic lateral sclerosis ATRX alpha thalassemia/mental retardation syndrome X-linked CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy CD cluster designation CEA carcinoembryonic antigen CJD Creutzfeldt Jakob disease CMV cytomegalovirus CNS central nervous system COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computerized tomography DNA deoxyribonucleic acid EBV Epstein-Barr virus EEG electroencephalogram EGFR epidermal growth factor receptor EM electron microscopy EMA epithelial membrane antigen EMG electromyography FDG-PET fluoro-deoxyglucose positron emission tomography GFAP glial fibrillary acidic protein GI gastrointestinal GMS Gomori (or Grocott) methenamine silver H & E hematoxylin & eosin HIV human immunodeficiency virus HPV human papillomavirus HSV herpes simplex virus IHC immunohistochemical LFB luxol fast blue MDMA methylenedioxymethamphetamine (Ecstasy) MR magnetic resonance MRI magnetic resonance imaging NMO neuromyolitis optica PAS periodic acid Schiff PCR polymerase chain reaction PDGFR platelet-derived growth factor receptor Pit1 growth hormone factor 1 PLAP placental alkaline phosphatase PPD test purified protein derivative PTAH phosphotungstic acid hematoxylin SF1 splicing factor 1 SPECT single photon emission tomography TDP-43 TAR DNA binding protein 43 TTF1 thyroid transcription factor WHO World Health Organization

Immunoreactive “to” not “for”. EM only for nerve and muscle and selected diseases in which EM is required. 2017 – Lhermitte-Duclos is now dysplastic cerebellar gangliocytoma; new term - solitary fibrous tumor/hemangiopericytoma 2018 - Status marmoratus is now remote hypoxia/ischemia, but not a universal change. Embryonal tumor with abundant neuropil and true rosettes is now embryonal tumor with multilayered rosettes.

Updated 5/2020

The Pediatric Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology

ALT alanine aminotransferase AST aspartate aminotransferase CA 125 cancer antigen 125 CBC complete blood count CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness. CPAM congenital pulmonary airway malformation CSF cerebrospinal fluid DHEA dehydroepiandrosterone DNA deoxyribonucleic acid EBV Epstein-Barr virus EBER EBV-encoded RNA ESR erythrocyte sedimentation rate FISH fluorescent in-situ hybridization G-6-PD glucose-6-phosphate dehydrogenase deficiency GM-CSF granulocyte-macrophage colony-stimulating factor HCG human chorionic gonadotropin HUS hemolytic uremic syndrome HVA/VMA homovanillic acid/vanillylmandelic acid IgA immunoglobulin A IgD immunoglobulin D IgE immunoglobulin E IgG immunoglobulin G IgM immunoglobulin M IPEX immunodysregulation polyendocrinopathy enteropathy x-linked syndrome IUGR intrauterine growth restriction MEN IIb multiple endocrine neoplasia type 2 mRNA messenger ribonucleic acid NF neurofibromatosis PAS periodic acid Schiff PEComa perivascular epithelioid cell tumor PTLD post-transplant lymphoproliferative disorder SIDS sudden infant death syndrome SUDI sudden unexpected death in infancy VACTERL vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities VMA vanillylmandelic acid WAGR Wilms tumour, aniridia, genitourinary anomalies, and retardation WBC white blood cell If a syndrome is named after a patient, there is an apostrophe – Lou Gehrig’s disease. If it is named after the doctor, there is no apostrophe.