The Dana Farber/Harvard Cancer Center and TREC presents…

The 4th annual Celebration of

Junior Investigators In Cancer Research

November 14th, 2016

Sponsored by:

The Dana-Farber/Harvard Cancer Center Programs of Cancer Data Sciences, Cancer Epidemiology, Cancer Care Delivery Research, Cancer Risk and Disparities

Harvard Transdisciplinary Research in Energetics and Cancer (TREC)

CELEBRATION OF JUNIOR INVESTIGATORS IN CANCER RESEARCH

FRIDAY, NOVEMBER 14th, 2016

Yawkey Conference Center, Dana-Farber Cancer Center Introduction from the Organizers Young investigators are a unique reservoir of new ideas, innovation, energy and genius in cancer research. Thus, we organized this half-day symposium to showcase the young talent at the Dana-Farber/Harvard Cancer Center (DF/HCC) who are producing key research in several areas of population science, including epidemiology, biostatistics, outcomes, diversity and survivorship. We look forward to an exciting afternoon of discussion, sharing new discoveries, and building new collaborations. – Lorelei Mucci, ScDHSPH; Meir Stampfer, MD, DrPHBWH, Giovanni Parmigiani, PhDDFCI, Erica FeickDFCI and Sam PeischHSPH Schedule of Events Yawkey Conference Center, Dana-Farber Cancer Center 2:00-2:05pm Introduction 2:05-3:05pm Plenary talk by Karen Emmons, PhD

“Realizing the Potential of Cancer Prevention in a Precision Era.” 3:05-3:20pm Coffee break 3:20-4:45 pm Short oral presentations (overview and schedule on next page) 4:45-5:00 pm Words from Dr. Laurie Glimcher, MD 5:00-6:00pm Poster session (viewings, groups led by faculty, active

discussions) 6:00-6:10pm Closing Remarks by Dr. Frank Hu, MD 6:10-6:15pm Award Announcement by Dr. Giovanni Parmigiani, PhD

Oral Presentations Schedule: 3:20-4:45pm in the Yawkey Conference Center, Dana-Farber Cancer Institute Time Name Institution(s) Title

3:20-3:25 Garcia de Albeniz HSPH Colonoscopy and risk of infective endocarditis in the elderly

3:25-3:30 Peter James HSPH Light at night and breast cancer incidence in the Nurses’ Health Study II

3:30-3:35 Loren Saulsberry DF/HCC The impact of breast density notification laws on the use of supplemental breast cancer screening procedures

3:35-3:40 BREAK FOR QUESTIONS

3:40-3:45 Helian Feng HSPH/DFCI A multi-tissue transcriptome-wide association study of breast cancer identifies 29 novel breast cancer susceptibility loci

3:45-3:50 Kathryn Wilson HSPH Baseline prostate-specific antigen (PSA) levels in midlife predict aggressive prostate cancer in African-American men

3:50-3:55 Salome Kuchukhidze

MGH Knowledge and interest in lung cancer screening among community health center current and former smokers

3:55-4:00 Maud Fagny DF/HCC A network-based approach to eQTL interpretation and SNP functional characterization

4:00-4:05 Catherine Marinac HSPH Associations between timing of meals, physical activity, light exposure, and sleep with body mass index in free-living adults

4:05-4:10 Maxine Sun DF/HCC Cognitive impairment after androgen deprivation therapy for advanced prostate cancer: a retrospective analysis and a pooled-analysis.

4:10-4:25 BREAK FOR QUESTIONS

4:25-4:30 Thomas Madsen DFCI Peeling and paring: an algorithm for computing carrier probabilities for an arbitrary number of loci in pedigree data

4:30-4:35 Mesfin Bekalu DF/HCC

Emotional and cognitive reactions to tobacco graphic health warnings (GHWs) and associated quit attempts among low socioeconomic position (SEP) populations

4:35-4:45 BREAK FOR QUESTIONS

Poster Session: 5:00-6:00pm in the Yawkey Conference Center, Dana-Farber Cancer Institute

# Name Institution(s) Title Faculty

Discussant

1 David Cheng HSPH

Inverse probability weighting with a response-informed calibrated propensity score: a robust and efficient approach for treatment effects in

large observational studies

Mucci

2 Claire Kim BWH Stability and reproducibility of proteomic

profiles measured with SOMAscan platform Mucci

3 Anupriya Dutta DFCI Racial differences in prostate cancer risk in

young HIV-positive and HIV-negative men: a prospective cohort study

Mucci

4 Peter James HSPH GPS-based exposure to greenness and objectively measured physical activity

Mucci

5 Prasanna Ananth DF/BCC and

Blood Disorders Center

Providers perspectives on use of medical marijuana in pediatric oncology patients

Mucci

6 Anish Mehta BWH Mediators of disparities in survival among patients with non-small cell lung cancer

Stampfer

7 Xia Jiang HSPH Analysis of shared heritability and functional

enrichment based on genome-wide association studies for five common cancers

Stampfer

8 Trang VoPham HSPH Environmental radon and breast cancer risk in

the Nurses’ Health Study II Stampfer

9 Dana Footer DF/BCC and

Blood Disorders Center

Pain in survivors of pediatric brain tumors

Stampfer

10 Claire Pernar HSPH Physical activity and risk of prostate cancer

defined by TMPRSS2:ERG Stampfer

11 Ericka Ebot HSPH Gene expression profiling of prostate tissue identifies biological pathways

associated with TMPRSS2:ERG gene fusion Hu

12 Sarah Markt HSPH

Age ≥ 40 years is associated with adverse outcomes in metastatic germ cell cancer

despite appropriate intended chemotherapy

Hu

13 Aymen Elfiky DFCI Short-term mortality prediction using a machine learning algorithm for patients

initiating chemotherapy Hu

14 Giselle Perez-

Lougee MGH

Promoting resiliency among palliative care clinicians: stressors, coping strategies, and

training needs Hu

15 Giselle Perez-

Lougee MGH

Mental health insurance preferences, coverage and utilization among childhood

cancer survivors Hu

16 Zoe Guan DFCI/HSPH BRCA-Gail: a combination model for breast

cancer risk prediction Parmigiani

17 Theo Huang DFCI/HSPH Using frailty models to improve familial

cancer risk prediction Parmigiani

18 Jiabei Yang DFCI/HSPH A tool to predict cancer risk with

uncommon genetic mutations Parmigiani

19 Shoshana

Rosenberg DFCI

Employment trends in young women following a breast cancer diagnosis

Parmigiani

20 Maxine Chen CDNM—

BWH/HMS Transcriptome-wide association study of

prostate cancer risk. Parmigiani

21 Joseph Paulson DFCI/HSPH Tissue-aware RNA-Seq processing and normalization for heterogeneous and

sparse data Parmigiani

22 Marieke Kuijjer DFCI Modeling the effects of gene regulation on

glioblastoma survival using individual patient networks

Trippa

23 Camila Lopes-

Ramos DFCI

Sexual dimorphism in colon cancer revealed by gene regulatory networks

Trippa

24 Evan Busch BWH/HMS/HSPH Mutations in genes related to epithelial-mesenchymal transition in carcinomas

Trippa

25 Candice Chow DFCI Relapse as a risk factor for anxiety in

adolescent and young adult survivors of pediatric brain tumors

Trippa

26 Mary Kathryn

Downer HSPH

Aspirin use and the risk of lethal prostate cancer in the Physicians' Health Study

Trippa

27 Kevin Kensler HSPH Androgen receptor expression and breast cancer survival in the Nurses’ Health Study

cohorts Mack

28 Megan Rice MGH/HMS Texture variation on a mammogram and

risk of breast cancer Mack

29 Natalie DuPre HSPH Particulate matter exposures in relation to

breast cancer survival Mack

30 Ilaria Domenicano DFCI A Bayesian information-driven phase I/II

dose-finding design

Mack

31 Mollie Barnard HSPH Analgesic use and risk of ovarian cancer in

the Nurses’ Health Studies Mucci

32 Sarah Mantwill DFCI

Interpersonal communication about graphic health warning labels in a

vulnerable population – Predictors and smoking-related consequences of

conversations

Hu

Notes:

DF/HCC Population Sciences Programs