T cell ontology Revision

T cells

• 34 terms for types of T cell currently exist in the Cell Ontology.

• Broadly divided into immature and mature subsets, and into alpha-beta and gamma-delta subsets.

• The genus term ‘T cell’ is the parent term for all types of T cell.

Immature T cells

Mature T cells

T Cell Ontology

General issues for T cells– Introduce “thymocyte” to replace immature– Make definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25-

– Introduce the concept of naïve versus antigen experienced T cell - instead of “mature”

– Add additional T helper subsets - introduce transcription factors as part of the definition

Changes made– Collapsed immature and mature T cell into the T cell term– Made definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25-

– Added some generic terms such as helper T cell, memory T cell– A few cells have two parents– Expanded the development stages

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T cell overview

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T cell development

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NK T cells

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Definitions include CD markers and TFs