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Swerdlow S et al . Blood 2016
Hong JY et al Curr opin Oncol 2015
Epidemiology
• Age cutoff
• Percentage of EBV+ tumor cells
• Morphologic heterogeneity
Hong JY et al Cur opinion in Oncol 2015
Immunosenescence• The gradual deterioration of the immune system caused by the ageing process• Continuous remodeling process of immune system
(not just decline of immune function): decrease of B-cell diversity & increase of clonal expansions of B-cells: decrease of CD4+/CD8+ T cell counts
Swerdlow S et al . Blood 2016
Hong JY et al. Ann Oncol 2015
EBV+ large B-cell lymphoma in young patients
Nicolae A et al Blood 2015
Hong JY et al Cur opinion in Oncol 2015
EBV+ large B-cell lymphoma
Nicolae A et al Blood 2015
Study of Ibrutinib in Combination With Rituximab-CHOP in
Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma
Brentuximab Vedotin + Rituximab as Frontline Therapy for
Pts w/ CD30+ and/or EBV+ Lymphomas
Cellular Immunotherapy for Viral Induced Cancer - EBV
Positive Lymphomas (CIVIC)
Study Of Durvalumab and Lenalidomide In R/R EBV
Associated DLBCL Subtypes, Primary CNS And Testicular
DLBCL
Kataoka K et al. Leukemia 2018
Kataoka K et al. Leukemia 2018
Kim SJ et al . Cancer Res and Tx 2018
SMC lymphoma teams
CISL members