Supplementary Table 1. Detailed clinical informationdc f o · DNAJC7 DnaJ heat shock protein family (Hsp40) member C7(DNAJC7) 0.601 0.003 UQCC2 ubiquinol-cytochrome c reductase complex

Keun Soo Ahn, et al: Genetic features of intrahepatic cholangiocarcinoma according to FDG uptake

Ann Surg Treat Res 2019;96(4):153-161https://doi.org/10.4174/astr.2019.96.4.153

Supplementary Table 1. Detailed clinical informationSupplementary Table 1. Detailed clinical information

ID Sex Age SUVmax Recurrence Disease free period (mDeath Overall survival (month CEA (mg/dLCA19-9 (U/mDifferenciati Vascular invTumor size( Stage

1T Male 54 8.65 No 112.6 No 112.6 1.14 12.9 Mod No 5 I

2T Male 49 5.47 Yes 3.9 Yes 14.3 1.15 128.5 NA No 16.5 I

4T Male 55 13.79 Yes 1.7 Yes 18.1 2.1 3049 Mod Yes 4.6 II

5T Male 61 6.16 Yes 9.6 Yes 24.3 12.8 26.08 Mod No 4.5 I

6T Male 65 6.1 Yes 57.3 No 99.0 1.84 169.71 Mod No 12 I

7T Male 53 11.89 Yes 3.3 Yes 18.9 1.89 119.43 Mod Yes 4 IVB

11T Male 79 7.73 No 17.3 No 17.3 1.9 40.19 Mod Yes 6 II

13T Male 63 8.5 Yes 9.2 Yes 38.2 1.6 NA Mod No 8.7 I

15T Male 60 4.46 Yes 21.8 Yes 25.6 3.17 831.04 Mod Yes 5 IVA

16T Male 67 7.46 No 65.2 Yes 68.2 2.14 18.85 Poor Yes 8 II

17T Male 69 12.12 Yes 6.9 Yes 28.3 NA 262.08 Mod Yes 5 II

18T Male 75 9.6 Yes 6.1 Yes 26.3 1.5 22.03 Poor Yes 4.5 IVA

19T Male 76 5.58 Yes 16.6 Yes 30.3 1.41 206.26 Mod No 4.3 I

20T Female 76 10.14 Yes 6.0 Yes 6.7 NA 10.1 Mod No 6.5 IVA

21T Male 75 1.82 No 41.7 No 41.7 NA NA Mod No 2.7 I

22T Female 67 2.79 No 54.1 No 54.1 0.5 22.1 Mod No 3.5 I

23T Male 73 11.1 Yes 40.0 No 46.6 4.25 8.3 Mod No 4 I

24T Female 63 8.41 No 49.7 No 49.7 2.74 12.1 Poor No 4.5 I

25T Male 58 12.5 Yes 17.3 Yes 35.5 1.13 4.21 Mod No 3.5 IVA26T Male 51 11.79 Yes 25.7 Yes 29.4 1.6 1.2 Mod No 4.2 I27T Female 74 8.79 Yes 26.7 No 23.1 12.5 5950.55 Poor No 12.5 III

29T Female 59 9.04 No 40.2 No 40.2 1.31 1.2 Mod No 10.5 I

SUVmax, maximum standard uptake value.



Supplementary Table 2. Gene lists of positively correlated with maximum standard uptake valueSupplementary Table 2. Gene lists of positively correlated with SUVmax

Gene symbol Gene name Pearson coefficient PLRRC59 leucine rich repeat containing 59(LRRC59) 0.702 0.000LSM12 LSM12 homolog(LSM12) 0.681 0.000EIF4A3 eukaryotic translation initiation factor 4A3(EIF4A3) 0.675 0.001DTD1 D-tyrosyl-tRNA deacylase 1(DTD1) 0.667 0.001SRP19 signal recognition particle 19(SRP19) 0.661 0.001KIFC1 kinesin family member C1(KIFC1) 0.660 0.001RRP36 ribosomal RNA processing 36(RRP36) 0.656 0.001BYSL bystin like(BYSL) 0.648 0.001RNASEH2A ribonuclease H2 subunit A(RNASEH2A) 0.640 0.001IFI27L1 interferon alpha inducible protein 27 like 1(IFI27L1) 0.638 0.001PFDN2 prefoldin subunit 2(PFDN2) 0.634 0.002ENO1 enolase 1(ENO1) 0.627 0.002LRR1 leucine rich repeat protein 1(LRR1) 0.624 0.002WDR4 WD repeat domain 4(WDR4) 0.620 0.002P4HA2 prolyl 4-hydroxylase subunit alpha 2(P4HA2) 0.610 0.003EME1 essential meiotic structure-specific endonuclease 1(EME1) 0.609 0.003DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1(DYNC1LI1) 0.607 0.003RRM2 ribonucleotide reductase regulatory subunit M2(RRM2) 0.605 0.003PLXNA1 plexin A1(PLXNA1) 0.602 0.003DNAJC7 DnaJ heat shock protein family (Hsp40) member C7(DNAJC7) 0.601 0.003UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2(UQCC2) 0.597 0.003SPC25 SPC25, NDC80 kinetochore complex component(SPC25) 0.597 0.003LMNB1 lamin B1(LMNB1) 0.596 0.003NOC4L nucleolar complex associated 4 homolog(NOC4L) 0.596 0.003NDUFS6 NADH:ubiquinone oxidoreductase subunit S6(NDUFS6) 0.593 0.004CCT5 chaperonin containing TCP1 subunit 5(CCT5) 0.592 0.004GMPS guanine monophosphate synthase(GMPS) 0.592 0.004HJURP Holliday junction recognition protein(HJURP) 0.591 0.004HNRNPA3 heterogeneous nuclear ribonucleoprotein A3(HNRNPA3) 0.590 0.004KPNA2 karyopherin subunit alpha 2(KPNA2) 0.590 0.004NUDT15 nudix hydrolase 15(NUDT15) 0.587 0.004PTTG1 pituitary tumor-transforming 1(PTTG1) 0.582 0.004RNF8 ring finger protein 8(RNF8) 0.582 0.005CENPA centromere protein A(CENPA) 0.581 0.005UBE2D2 ubiquitin conjugating enzyme E2 D2(UBE2D2) 0.580 0.005HMGA1 high mobility group AT-hook 1(HMGA1) 0.579 0.005CDC45 cell division cycle 45(CDC45) 0.579 0.005TRIM59 tripartite motif containing 59(TRIM59) 0.578 0.005GATAD2A GATA zinc finger domain containing 2A(GATAD2A) 0.575 0.005FANCE Fanconi anemia complementation group E(FANCE) 0.573 0.005ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9)(ATP5G1) 0.573 0.005BRCA1 BRCA1, DNA repair associated(BRCA1) 0.572 0.005CDC20 cell division cycle 20(CDC20) 0.571 0.006UCHL3 ubiquitin C-terminal hydrolase L3(UCHL3) 0.568 0.006TRIP13 thyroid hormone receptor interactor 13(TRIP13) 0.568 0.006FBXO32 F-box protein 32(FBXO32) 0.567 0.006DLGAP5 DLG associated protein 5(DLGAP5) 0.567 0.006TPM3 tropomyosin 3(TPM3) 0.566 0.006RNASEH1 ribonuclease H1(RNASEH1) 0.565 0.006PRELID2 PRELI domain containing 2(PRELID2) 0.560 0.007CDK1 cyclin dependent kinase 1(CDK1) 0.558 0.007NOMO1 NODAL modulator 1(NOMO1) 0.558 0.007BIRC5 baculoviral IAP repeat containing 5(BIRC5) 0.556 0.007CKAP2 cytoskeleton associated protein 2(CKAP2) 0.554 0.007GLO1 glyoxalase I(GLO1) 0.554 0.008FEN1 flap structure-specific endonuclease 1(FEN1) 0.553 0.008PDCD5 programmed cell death 5(PDCD5) 0.552 0.008UBE2I ubiquitin conjugating enzyme E2 I(UBE2I) 0.552 0.008PSMC3IP PSMC3 interacting protein(PSMC3IP) 0.551 0.008OLA1 Obg like ATPase 1(OLA1) 0.551 0.008LLPH LLP homolog, long-term synaptic facilitation(LLPH) 0.550 0.008CENPQ centromere protein Q(CENPQ) 0.549 0.008SBP1 Selenium Binding Protein 1 0.548 0.008TMA16 translation machinery associated 16 homolog(TMA16) 0.547 0.008SNRPC small nuclear ribonucleoprotein polypeptide C(SNRPC) 0.547 0.008FOXK2 forkhead box K2(FOXK2) 0.545 0.009FAM110A family with sequence similarity 110 member A(FAM110A) 0.544 0.009MRPS10 mitochondrial ribosomal protein S10(MRPS10) 0.544 0.009CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7(CHCHD7) 0.543 0.009FARSB phenylalanyl-tRNA synthetase beta subunit(FARSB) 0.542 0.009AZI1 Azelaic acid induced 1 0.542 0.009ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4(ST6GALNAC4) 0.541 0.009SNRPF small nuclear ribonucleoprotein polypeptide F(SNRPF) 0.541 0.009HMMR hyaluronan mediated motility receptor(HMMR) 0.540 0.009PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase(PGAM5) 0.539 0.010



Supplementary Table 2. Continued

LHFPL5 lipoma HMGIC fusion partner-like 5(LHFPL5) 0.528 0.012KIAA1524 KIAA1524(KIAA1524) 0.528 0.012BRIX1 BRX1, biogenesis of ribosomes(BRIX1) 0.527 0.012GAPDH glyceraldehyde-3-phosphate dehydrogenase(GAPDH) 0.527 0.012THOC3 THO complex 3(THOC3) 0.526 0.012MRPL28 mitochondrial ribosomal protein L28(MRPL28) 0.525 0.012PLEK2 pleckstrin 2(PLEK2) 0.525 0.012COA3 cytochrome c oxidase assembly factor 3(COA3) 0.524 0.012CDC16 cell division cycle 16(CDC16) 0.523 0.012OGFOD3 2-oxoglutarate and iron dependent oxygenase domain containing 3(OGFOD3) 0.522 0.013SNRPB small nuclear ribonucleoprotein polypeptides B and B1(SNRPB) 0.522 0.013EDARADD EDAR associated death domain(EDARADD) 0.522 0.013RACGAP1 Rac GTPase activating protein 1(RACGAP1) 0.522 0.013FAM64A family with sequence similarity 64 member A(FAM64A) 0.521 0.013PRIM2 primase (DNA) subunit 2(PRIM2) 0.521 0.013CCNB1 cyclin B1(CCNB1) 0.519 0.013MFSD2B major facilitator superfamily domain containing 2B(MFSD2B) 0.519 0.013TRAIP TRAF interacting protein(TRAIP) 0.519 0.013KIF4A kinesin family member 4A(KIF4A) 0.519 0.013CDKN3 cyclin dependent kinase inhibitor 3(CDKN3) 0.518 0.013PPARD peroxisome proliferator activated receptor delta(PPARD) 0.518 0.014HSPB11 heat shock protein family B (small) member 11(HSPB11) 0.517 0.014TONSL tonsoku-like, DNA repair protein(TONSL) 0.515 0.014PRR11 proline rich 11(PRR11) 0.514 0.014MKI67 marker of proliferation Ki-67(MKI67) 0.513 0.015TPX2 TPX2, microtubule nucleation factor(TPX2) 0.513 0.015CDCA4 cell division cycle associated 4(CDCA4) 0.512 0.015NCAPG non-SMC condensin I complex subunit G(NCAPG) 0.512 0.015GINS2 GINS complex subunit 2(GINS2) 0.512 0.015CCDC167 coiled-coil domain containing 167(CCDC167) 0.511 0.015C12orf45 chromosome 12 open reading frame 45(C12orf45) 0.511 0.015SPAG5 sperm associated antigen 5(SPAG5) 0.511 0.015FAM207A family with sequence similarity 207 member A(FAM207A) 0.510 0.015MLX MLX, MAX dimerization protein(MLX) 0.510 0.015CNPY3 canopy FGF signaling regulator 3(CNPY3) 0.510 0.015SHCBP1 SHC binding and spindle associated 1(SHCBP1) 0.509 0.016EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) 0.508 0.016PDXK pyridoxal (pyridoxine, vitamin B6) kinase(PDXK) 0.507 0.016C1orf74 chromosome 1 open reading frame 74(C1orf74) 0.507 0.016TFB1M transcription factor B1, mitochondrial(TFB1M) 0.507 0.016ADA adenosine deaminase(ADA) 0.507 0.016ATP6V1G2-DDX39B ATP6V1G2-DDX39B readthrough (NMD candidate)(ATP6V1G2-DDX39B) 0.507 0.016LSM2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated(LSM2) 0.506 0.016FAM104A family with sequence similarity 104 member A(FAM104A) 0.505 0.016MEA1 male-enhanced antigen 1(MEA1) 0.505 0.016APOL1 apolipoprotein L1(APOL1) 0.505 0.017MAPRE3 microtubule associated protein RP/EB family member 3(MAPRE3) 0.505 0.017SNF8 SNF8, ESCRT-II complex subunit(SNF8) 0.505 0.017NUDT1 nudix hydrolase 1(NUDT1) 0.504 0.017TOP2A topoisomerase (DNA) II alpha(TOP2A) 0.504 0.017U2AF1 U2 small nuclear RNA auxiliary factor 1(U2AF1) 0.503 0.017SAAL1 serum amyloid A like 1(SAAL1) 0.502 0.017TPI1 triosephosphate isomerase 1(TPI1) 0.502 0.017UHRF1 ubiquitin like with PHD and ring finger domains 1(UHRF1) 0.501 0.017AKIP1 A-kinase interacting protein 1(AKIP1) 0.501 0.018GTF2F2 general transcription factor IIF subunit 2(GTF2F2) 0.501 0.018

KIF20A kinesin family member 20A(KIF20A) 0.537 0.010KIF18B kinesin family member 18B(KIF18B) 0.537 0.010PTBP3 polypyrimidine tract binding protein 3(PTBP3) 0.537 0.010ASF1B anti-silencing function 1B histone chaperone(ASF1B) 0.535 0.010UBE2S ubiquitin conjugating enzyme E2 S(UBE2S) 0.534 0.010NDC80 NDC80, kinetochore complex component(NDC80) 0.534 0.010CMAS cytidine monophosphate N-acetylneuraminic acid synthetase(CMAS) 0.534 0.011CCT4 chaperonin containing TCP1 subunit 4(CCT4) 0.532 0.011NUFIP1 NUFIP1, FMR1 interacting protein 1(NUFIP1) 0.532 0.011PPIL1 peptidylprolyl isomerase like 1(PPIL1) 0.531 0.011PGAM1 phosphoglycerate mutase 1(PGAM1) 0.531 0.011HNRNPAB heterogeneous nuclear ribonucleoprotein A/B(HNRNPAB) 0.529 0.011

Gene symbol Gene name Pearson coefficient P



Supplementary Table 3. Gene lists of negatively correlated with SUVmaxSupplementary Table 3. Gene lists of negatively correlated with SUVmax

Gene symbol Gene name Pearson coefficient PSLC27A2 solute carrier family 27 member 2(SLC27A2) -0.686 0.000OXTR oxytocin receptor(OXTR) -0.684 0.000TMEM86B transmembrane protein 86B(TMEM86B) -0.673 0.001HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1(HERPUD1) -0.666 0.001CXCL12 C-X-C motif chemokine ligand 12(CXCL12) -0.661 0.001PARD6B par-6 family cell polarity regulator beta(PARD6B) -0.659 0.001COLEC11 collectin subfamily member 11(COLEC11) -0.652 0.001PRR26 proline rich 26(PRR26) -0.636 0.001ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16(ADAMTS16) -0.632 0.002CYP2B6 cytochrome P450 family 2 subfamily B member 6(CYP2B6) -0.631 0.002TMEM60 transmembrane protein 60(TMEM60) -0.626 0.002SOGA2 Suppressor of glucose autophagy associated 2 -0.626 0.002GIMAP8 GTPase, IMAP family member 8(GIMAP8) -0.622 0.002TPPP3 tubulin polymerization promoting protein family member 3(TPPP3) -0.617 0.002CYYR1 cysteine and tyrosine rich 1(CYYR1) -0.617 0.002ART4 ADP-ribosyltransferase 4 (Dombrock blood group)(ART4) -0.615 0.002FAM200B family with sequence similarity 200 member B(FAM200B) -0.615 0.002NPR1 natriuretic peptide receptor 1(NPR1) -0.613 0.002FXYD6 FXYD domain containing ion transport regulator 6(FXYD6) -0.608 0.003ST7L suppression of tumorigenicity 7 like(ST7L) -0.601 0.003SCAND2P SCAN domain containing 2 pseudogene(SCAND2P) -0.599 0.003DTWD1 DTW domain containing 1(DTWD1) -0.598 0.003GUCD1 guanylyl cyclase domain containing 1(GUCD1) -0.598 0.003GIMAP7 GTPase, IMAP family member 7(GIMAP7) -0.595 0.003BCL2 BCL2, apoptosis regulator(BCL2) -0.595 0.004AKAP9 A-kinase anchoring protein 9(AKAP9) -0.590 0.004LDB2 LIM domain binding 2(LDB2) -0.590 0.004CLEC3B C-type lectin domain family 3 member B(CLEC3B) -0.590 0.004FZD4 frizzled class receptor 4(FZD4) -0.589 0.004SERINC4 serine incorporator 4(SERINC4) -0.588 0.004RERG RAS like estrogen regulated growth inhibitor(RERG) -0.588 0.004IGFBP7 insulin like growth factor binding protein 7(IGFBP7) -0.583 0.004DPYSL2 dihydropyrimidinase like 2(DPYSL2) -0.581 0.005PDGFD platelet derived growth factor D(PDGFD) -0.580 0.005EXOC3L2 exocyst complex component 3 like 2(EXOC3L2) -0.576 0.005ULK3 unc-51 like kinase 3(ULK3) -0.571 0.006COL14A1 collagen type XIV alpha 1 chain(COL14A1) -0.570 0.006ACMSD aminocarboxymuconate semialdehyde decarboxylase(ACMSD) -0.570 0.006RDH5 retinol dehydrogenase 5(RDH5) -0.569 0.006LPIN2 lipin 2(LPIN2) -0.568 0.006CTTNBP2 cortactin binding protein 2(CTTNBP2) -0.567 0.006SERPINA7 serpin family A member 7(SERPINA7) -0.566 0.006RAMP3 receptor activity modifying protein 3(RAMP3) -0.563 0.006MFAP4 microfibrillar associated protein 4(MFAP4) -0.561 0.007KCNH3 potassium voltage-gated channel subfamily H member 3(KCNH3) -0.561 0.007CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1) -0.558 0.007CALCRL calcitonin receptor like receptor(CALCRL) -0.556 0.007SESN2 sestrin 2(SESN2) -0.555 0.007FGD4 FYVE, RhoGEF and PH domain containing 4(FGD4) -0.554 0.007CCDC3 coiled-coil domain containing 3(CCDC3) -0.553 0.008SDPR serum deprivation response(SDPR) -0.552 0.008ASPHD1 aspartate beta-hydroxylase domain containing 1(ASPHD1) -0.551 0.008SLC1A1 solute carrier family 1 member 1(SLC1A1) -0.550 0.008PANK1 pantothenate kinase 1(PANK1) -0.550 0.008CYP4V2 cytochrome P450 family 4 subfamily V member 2(CYP4V2) -0.546 0.009EMCN endomucin(EMCN) -0.545 0.009COLEC10 collectin subfamily member 10(COLEC10) -0.544 0.009BIVM basic, immunoglobulin-like variable motif containing(BIVM) -0.543 0.009MCCC1 methylcrotonoyl-CoA carboxylase 1(MCCC1) -0.543 0.009PLA2G6 phospholipase A2 group VI(PLA2G6) -0.543 0.009NGFR nerve growth factor receptor(NGFR) -0.541 0.009ALDH1B1 aldehyde dehydrogenase 1 family member B1(ALDH1B1) -0.541 0.009MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3(MAGI3) -0.540 0.009CNOT6L CCR4-NOT transcription complex subunit 6 like(CNOT6L) -0.540 0.010RCAN2 regulator of calcineurin 2(RCAN2) -0.540 0.010GIMAP6 GTPase, IMAP family member 6(GIMAP6) -0.539 0.010ITGA9 integrin subunit alpha 9(ITGA9) -0.538 0.010ANGPTL1 angiopoietin like 1(ANGPTL1) -0.538 0.010CLEC10A C-type lectin domain family 10 member A(CLEC10A) -0.536 0.010G6PC glucose-6-phosphatase catalytic subunit(G6PC) -0.536 0.010PEX12 peroxisomal biogenesis factor 12(PEX12) -0.535 0.010S1PR1 sphingosine-1-phosphate receptor 1(S1PR1) -0.535 0.010MZF1 myeloid zinc finger 1(MZF1) -0.535 0.010PDZD8 PDZ domain containing 8(PDZD8) -0.531 0.011MECP2 methyl-CpG binding protein 2(MECP2) -0.531 0.011



C2orf74 chromosome 2 open reading frame 74(C2orf74) -0.519 0.013RRAGB Ras related GTP binding B(RRAGB) -0.519 0.013C11orf71 chromosome 11 open reading frame 71(C11orf71) -0.519 0.013ABCC3 ATP binding cassette subfamily C member 3(ABCC3) -0.518 0.014CD27 CD27 molecule(CD27) -0.518 0.014HGD homogentisate 1,2-dioxygenase(HGD) -0.518 0.014KDR kinase insert domain receptor(KDR) -0.517 0.014CD81 CD81 molecule(CD81) -0.516 0.014GSTA2 glutathione S-transferase alpha 2(GSTA2) -0.516 0.014ZMYM6 zinc finger MYM-type containing 6(ZMYM6) -0.516 0.014MMP24 matrix metallopeptidase 24(MMP24) -0.516 0.014ZBTB44 zinc finger and BTB domain containing 44(ZBTB44) -0.515 0.014GJB1 gap junction protein beta 1(GJB1) -0.514 0.014C14orf105 chromosome 14 open reading frame 105(C14orf105) -0.514 0.014IL6ST interleukin 6 signal transducer(IL6ST) -0.513 0.015SCMH1 sex comb on midleg homolog 1 (Drosophila)(SCMH1) -0.513 0.015THSD4 thrombospondin type 1 domain containing 4(THSD4) -0.511 0.015FRZB frizzled-related protein(FRZB) -0.511 0.015RPL9P25 ribosomal protein L9 pseudogene 25(RPL9P25) -0.509 0.016MYCT1 myc target 1(MYCT1) -0.509 0.016ARID4A AT-rich interaction domain 4A(ARID4A) -0.508 0.016FAXDC2 fatty acid hydroxylase domain containing 2(FAXDC2) -0.507 0.016LHFP lipoma HMGIC fusion partner(LHFP) -0.507 0.016CYP4A11 cytochrome P450 family 4 subfamily A member 11(CYP4A11) -0.506 0.016KIAA0430 KIAA0430(KIAA0430) -0.504 0.017LTB4R2 leukotriene B4 receptor 2(LTB4R2) -0.503 0.017CLEC14A C-type lectin domain family 14 member A(CLEC14A) -0.503 0.017INSR insulin receptor(INSR) -0.503 0.017SPG20 spastic paraplegia 20 (Troyer syndrome)(SPG20) -0.502 0.017GZMK granzyme K(GZMK) -0.502 0.017COCH cochlin(COCH) -0.501 0.018LAPTM4A lysosomal protein transmembrane 4 alpha(LAPTM4A) -0.500 0.018

SLC5A9 solute carrier family 5 member 9(SLC5A9) -0.530 0.011CRIM1 cysteine rich transmembrane BMP regulator 1(CRIM1) -0.530 0.011TGFBR3 transforming growth factor beta receptor 3(TGFBR3) -0.529 0.011WDR73 WD repeat domain 73(WDR73) -0.529 0.011MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1(MAGI1) -0.528 0.012SLC18A2 solute carrier family 18 member A2(SLC18A2) -0.527 0.012C7 complement C7(C7) -0.526 0.012AQP7 aquaporin 7(AQP7) -0.525 0.012ZNF75D zinc finger protein 75D(ZNF75D) -0.524 0.012SGSM2 small G protein signaling modulator 2(SGSM2) -0.522 0.013FCER1A Fc fragment of IgE receptor Ia(FCER1A) -0.521 0.013KRBOX4 KRAB box domain containing 4(KRBOX4) -0.520 0.013

Gene symbol Gene name Pearson coefficient P




Supplementary Table 4. List of activated pathway in patients with high SUVmax (>9.0) by Gene Set Enrichment AnalysisSupplementary Table 4. List of activated pathway in patients with high SUVmax (>9.0) by Gene Set Enrichment Analysis

NAME SIZE ES NES FDR q-val RANK AT MAX LEADING EDGEHALLMARK_E2F_TARGETS 182 0.672954 3.071104 0 2476 tags=60%, list=17%, signal=72%HALLMARK_G2M_CHECKPOINT 176 0.633055 2.903504 0 2476 tags=55%, list=17%, signal=65%HALLMARK_MYC_TARGETS_V1 198 0.557718 2.56348 0 4237 tags=58%, list=29%, signal=80%HALLMARK_MYC_TARGETS_V2 57 0.560001 2.159657 0 3134 tags=47%, list=21%, signal=60%HALLMARK_MTORC1_SIGNALING 189 0.463553 2.137892 0 2707 tags=38%, list=18%, signal=46%HALLMARK_TNFA_SIGNALING_VIA_NFKB 184 0.450381 2.095417 0 4130 tags=50%, list=28%, signal=68%HALLMARK_INTERFERON_GAMMA_RESPONSE 176 0.459489 2.082617 0 4164 tags=49%, list=28%, signal=67%HALLMARK_SPERMATOGENESIS 56 0.537532 2.074181 0 2437 tags=41%, list=16%, signal=49%HALLMARK_INTERFERON_ALPHA_RESPONSE 92 0.474614 1.980436 1.14E-04 4245 tags=46%, list=29%, signal=64%HALLMARK_MITOTIC_SPINDLE 174 0.396524 1.817037 0.001435221 2051 tags=29%, list=14%, signal=33%HALLMARK_PI3K_AKT_MTOR_SIGNALING 84 0.431341 1.772405 0.001926436 3793 tags=43%, list=26%, signal=57%HALLMARK_INFLAMMATORY_RESPONSE 141 0.391515 1.719219 0.00353271 4329 tags=45%, list=29%, signal=63%HALLMARK_ALLOGRAFT_REJECTION 145 0.35684 1.583373 0.013532296 4245 tags=46%, list=29%, signal=64%HALLMARK_CHOLESTEROL_HOMEOSTASIS 68 0.393893 1.558258 0.01580926 4132 tags=44%, list=28%, signal=61%HALLMARK_GLYCOLYSIS 177 0.338494 1.544647 0.017648138 2766 tags=29%, list=19%, signal=36%HALLMARK_APICAL_SURFACE 29 0.463794 1.518987 0.021857122 379 tags=21%, list=3%, signal=21%HALLMARK_UV_RESPONSE_UP 134 0.334759 1.483864 0.02962938 3323 tags=34%, list=22%, signal=44%HALLMARK_OXIDATIVE_PHOSPHORYLATION 199 0.320804 1.479457 0.029400675 5549 tags=51%, list=37%, signal=80%HALLMARK_HYPOXIA 173 0.311875 1.432663 0.04571888 2707 tags=29%, list=18%, signal=35%HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY 45 0.382013 1.418682 0.049561933 4967 tags=53%, list=33%, signal=80%

KEGG_DNA_REPLICATION 34 0.709484 2.464287 0 2318 tags=71%, list=16%, signal=83%KEGG_CELL_CYCLE 113 0.550076 2.349128 0 3312 tags=53%, list=22%, signal=68%KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 53 0.555476 2.109752 3.60E-04 4245 tags=58%, list=29%, signal=82%KEGG_GRAFT_VERSUS_HOST_DISEASE 24 0.65822 2.091319 2.70E-04 3638 tags=67%, list=25%, signal=88%KEGG_AUTOIMMUNE_THYROID_DISEASE 24 0.621477 1.967446 0.003745345 3638 tags=63%, list=25%, signal=83%KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 64 0.505271 1.962603 0.003848868 2585 tags=44%, list=17%, signal=53%KEGG_NUCLEOTIDE_EXCISION_REPAIR 39 0.535536 1.931594 0.004972761 2539 tags=51%, list=17%, signal=62%KEGG_PROTEASOME 41 0.519293 1.893577 0.007372376 5275 tags=63%, list=36%, signal=98%KEGG_ALLOGRAFT_REJECTION 23 0.613951 1.890946 0.006792713 3638 tags=61%, list=25%, signal=81%KEGG_SPLICEOSOME 124 0.425529 1.864716 0.009102637 3680 tags=40%, list=25%, signal=53%KEGG_BASE_EXCISION_REPAIR 32 0.557279 1.853474 0.009055389 1453 tags=38%, list=10%, signal=41%KEGG_RNA_DEGRADATION 55 0.481265 1.852178 0.008569631 4770 tags=56%, list=32%, signal=83%KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 48 0.493669 1.838481 0.009210958 4113 tags=54%, list=28%, signal=75%KEGG_PARKINSONS_DISEASE 98 0.440691 1.819142 0.011189329 4565 tags=49%, list=31%, signal=70%KEGG_OOCYTE_MEIOSIS 81 0.441284 1.813784 0.011086314 3224 tags=37%, list=22%, signal=47%KEGG_TYPE_I_DIABETES_MELLITUS 27 0.549821 1.793786 0.0130208 3638 tags=56%, list=25%, signal=73%KEGG_ACUTE_MYELOID_LEUKEMIA 49 0.454342 1.689152 0.03836072 4391 tags=55%, list=30%, signal=78%KEGG_MISMATCH_REPAIR 21 0.549854 1.678839 0.03926936 2318 tags=52%, list=16%, signal=62%KEGG_PYRIMIDINE_METABOLISM 87 0.402774 1.670815 0.040788975 4079 tags=44%, list=27%, signal=60%KEGG_PENTOSE_PHOSPHATE_PATHWAY 22 0.53206 1.661243 0.042819418 2371 tags=45%, list=16%, signal=54%

BIOCARTA_CELLCYCLE_PATHWAY 22 0.701386 2.171198 0 3492 tags=77%, list=24%, signal=101%BIOCARTA_G1_PATHWAY 26 0.599599 1.932853 0.01968725 2374 tags=50%, list=16%, signal=59%BIOCARTA_MCM_PATHWAY 18 0.642132 1.882772 0.031457733 2224 tags=56%, list=15%, signal=65%BIOCARTA_MAL_PATHWAY 17 0.63584 1.864167 0.028473558 3137 tags=65%, list=21%, signal=82%BIOCARTA_ATRBRCA_PATHWAY 18 0.624912 1.828677 0.035451584 2332 tags=50%, list=16%, signal=59%

GO_MITOTIC_NUCLEAR_DIVISION 296 0.539809 2.598175 0 2653 tags=45%, list=18%, signal=53%GO_CELL_CYCLE_PHASE_TRANSITION 217 0.559054 2.582036 0 2739 tags=47%, list=18%, signal=57%GO_DNA_DEPENDENT_DNA_REPLICATION 79 0.634064 2.576273 0 2739 tags=57%, list=18%, signal=69%GO_DNA_REPLICATION 171 0.559183 2.540734 0 2402 tags=45%, list=16%, signal=53%GO_CELL_CYCLE_G1_S_PHASE_TRANSITION 93 0.602493 2.534596 0 2739 tags=54%, list=18%, signal=66%GO_ORGANELLE_FISSION 367 0.506111 2.496523 0 2653 tags=41%, list=18%, signal=49%GO_MITOTIC_SISTER_CHROMATID_SEGREGATION 75 0.607904 2.470165 0 1274 tags=37%, list=9%, signal=41%GO_SISTER_CHROMATID_SEGREGATION 141 0.5624 2.46894 0 1927 tags=40%, list=13%, signal=45%GO_SPINDLE_MICROTUBULE 49 0.651289 2.449998 0 851 tags=45%, list=6%, signal=47%GO_DNA_REPLICATION_INITIATION 25 0.749942 2.425618 0 1714 tags=68%, list=12%, signal=77%GO_NUCLEAR_CHROMOSOME_SEGREGATION 160 0.53273 2.41328 0 1927 tags=38%, list=13%, signal=43%GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION 80 0.588661 2.411103 0 4244 tags=70%, list=29%, signal=98%GO_CELL_DIVISION 361 0.493007 2.405026 0 2590 tags=38%, list=17%, signal=45%GO_CHROMOSOME_SEGREGATION 199 0.525114 2.404798 0 1927 tags=36%, list=13%, signal=40%GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS 180 0.516619 2.378795 6.90E-05 2703 tags=42%, list=18%, signal=51%GO_SPINDLE_ASSEMBLY 56 0.625315 2.378491 6.47E-05 2565 tags=57%, list=17%, signal=69%GO_SPINDLE 222 0.496654 2.361111 6.09E-05 2617 tags=41%, list=18%, signal=50%GO_KINETOCHORE 95 0.5638 2.347107 5.75E-05 4331 tags=63%, list=29%, signal=89%GO_SISTER_CHROMATID_COHESION 88 0.558897 2.323198 5.45E-05 4331 tags=65%, list=29%, signal=91%GO_CELL_CYCLE_G2_M_PHASE_TRANSITION 118 0.537788 2.321922 5.18E-05 2713 tags=46%, list=18%, signal=56%GO_REPLICATION_FORK 53 0.616349 2.313915 9.83E-05 2318 tags=53%, list=16%, signal=62%GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_ 138 0.527935 2.309555 9.38E-05 2623 tags=42%, list=18%, signal=51%GO_CHROMOSOME_CENTROMERIC_REGION 140 0.516797 2.295548 8.98E-05 4253 tags=57%, list=29%, signal=79%GO_DNA_RECOMBINATION 154 0.507093 2.28754 8.60E-05 2884 tags=47%, list=19%, signal=57%GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISAS 122 0.524154 2.277924 1.24E-04 2565 tags=43%, list=17%, signal=51%GO_MITOTIC_RECOMBINATION 35 0.658963 2.269058 1.19E-04 2739 tags=69%, list=18%, signal=84%GO_CONDENSED_CHROMOSOME 146 0.510741 2.266629 1.15E-04 4978 tags=69%, list=34%, signal=103%GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATAB 73 0.563607 2.266508 1.11E-04 2383 tags=44%, list=16%, signal=52%GO_MITOCHONDRIAL_TRANSLATION 106 0.532069 2.264106 1.07E-04 4304 tags=62%, list=29%, signal=87%GO_REGULATION_OF_CHROMOSOME_SEGREGATION 70 0.561668 2.250646 1.03E-04 2700 tags=50%, list=18%, signal=61%




GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_ 21 0.706436 2.177082 1.92E-04 1682 tags=57%, list=11%, signal=64%GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLIC 23 0.698266 2.170063 3.05E-04 2739 tags=74%, list=18%, signal=91%GO_TRANSLATIONAL_TERMINATION 92 0.516021 2.165015 2.98E-04 4304 tags=63%, list=29%, signal=88%GO_MITOTIC_SPINDLE_ASSEMBLY 31 0.645612 2.163945 2.92E-04 2186 tags=55%, list=15%, signal=64%GO_SPINDLE_POLE 94 0.515341 2.153462 2.86E-04 1830 tags=40%, list=12%, signal=46%GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATIO 290 0.448908 2.151614 3.01E-04 2649 tags=34%, list=18%, signal=41%GO_NUCLEAR_REPLICATION_FORK 33 0.620492 2.142568 3.79E-04 2915 tags=55%, list=20%, signal=68%GO_CELL_CYCLE_CHECKPOINT 162 0.470335 2.132512 4.94E-04 2895 tags=43%, list=20%, signal=53%GO_DNA_STRAND_ELONGATION 27 0.661452 2.13007 4.85E-04 3101 tags=70%, list=21%, signal=89%GO_MIDBODY 106 0.500832 2.124562 5.34E-04 3170 tags=40%, list=21%, signal=50%GO_CHROMOSOMAL_REGION 248 0.450267 2.124488 5.24E-04 4253 tags=50%, list=29%, signal=68%GO_REGULATION_OF_CENTROSOME_CYCLE 31 0.627762 2.119776 5.72E-04 2935 tags=58%, list=20%, signal=72%GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION 264 0.442091 2.118691 5.61E-04 2721 tags=36%, list=18%, signal=43%GO_DNA_CONFORMATION_CHANGE 178 0.463703 2.114704 5.88E-04 4341 tags=51%, list=29%, signal=71%GO_TRANSLATIONAL_ELONGATION 109 0.487721 2.110237 6.50E-04 4462 tags=58%, list=30%, signal=82%GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY 112 0.496959 2.103936 7.46E-04 4201 tags=57%, list=28%, signal=79%GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION 61 0.542285 2.101399 7.50E-04 2703 tags=46%, list=18%, signal=56%GO_REGULATION_OF_CELL_CYCLE_PROCESS 423 0.419039 2.082306 0.001011293 2721 tags=34%, list=18%, signal=40%GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR 55 0.542407 2.082153 9.95E-04 2739 tags=51%, list=18%, signal=62%GO_ORGANELLAR_RIBOSOME 69 0.522778 2.078424 0.001079056 4304 tags=65%, list=29%, signal=91%GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS 90 0.490701 2.07429 0.001078346 3429 tags=46%, list=23%, signal=59%GO_RESPONSE_TO_IONIZING_RADIATION 113 0.482356 2.063875 0.001270311 3135 tags=43%, list=21%, signal=55%GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS 31 0.608473 2.063258 0.001250768 3033 tags=58%, list=20%, signal=73%GO_DAMAGED_DNA_BINDING 54 0.54147 2.061391 0.001278893 1785 tags=39%, list=12%, signal=44%GO_REGULATION_OF_LIGASE_ACTIVITY 118 0.477499 2.058924 0.001336889 4397 tags=53%, list=30%, signal=75%GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION 55 0.533557 2.054762 0.001453922 2700 tags=47%, list=18%, signal=58%GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT 31 0.60584 2.052627 0.001521955 2784 tags=55%, list=19%, signal=67%GO_CENTROMERE_COMPLEX_ASSEMBLY 27 0.606811 2.047418 0.001588332 4703 tags=70%, list=32%, signal=103%GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS 173 0.448115 2.045258 0.001638392 2494 tags=36%, list=17%, signal=43%GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTIO 24 0.647971 2.045188 0.001615637 2404 tags=54%, list=16%, signal=65%GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GEN 19 0.686199 2.040366 0.001677751 2876 tags=63%, list=19%, signal=78%GO_MEIOTIC_CELL_CYCLE 105 0.480833 2.037539 0.001738357 4640 tags=63%, list=31%, signal=91%GO_CENTROSOME_CYCLE 31 0.594668 2.035194 0.00175642 3197 tags=61%, list=22%, signal=78%GO_ATP_DEPENDENT_CHROMATIN_REMODELING 51 0.539048 2.029844 0.001910235 4719 tags=63%, list=32%, signal=92%GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNO 18 0.690242 2.028631 0.001885427 2539 tags=50%, list=17%, signal=60%GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS 31 0.593181 2.028361 0.0018744 1825 tags=35%, list=12%, signal=40%GO_DNA_BIOSYNTHETIC_PROCESS 90 0.490962 2.025954 0.001942759 2739 tags=43%, list=18%, signal=53%GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY 100 0.475201 2.02152 0.0020598 4397 tags=52%, list=30%, signal=73%GO_NUCLEAR_CHROMOSOME 378 0.408567 2.019601 0.002085225 3217 tags=39%, list=22%, signal=48%GO_INTERCELLULAR_BRIDGE 35 0.569774 2.016868 0.0022111 2479 tags=54%, list=17%, signal=65%GO_CHROMOSOME_LOCALIZATION 46 0.549448 2.016176 0.002258654 851 tags=26%, list=6%, signal=28%GO_RECOMBINATIONAL_REPAIR 51 0.534995 2.013579 0.002366587 1718 tags=43%, list=12%, signal=49%GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_B 124 0.46039 2.011767 0.002399838 4513 tags=52%, list=30%, signal=74%GO_HISTONE_EXCHANGE 31 0.599433 2.006734 0.002694382 4703 tags=74%, list=32%, signal=108%GO_METAPHASE_PLATE_CONGRESSION 36 0.572689 2.00467 0.00275756 1791 tags=33%, list=12%, signal=38%GO_REGULATION_OF_MITOTIC_CELL_CYCLE 375 0.406401 1.999234 0.003077897 2721 tags=34%, list=18%, signal=40%GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT 25 0.615672 1.992699 0.00321667 2872 tags=56%, list=19%, signal=69%GO_DNA_INTEGRITY_CHECKPOINT 124 0.453917 1.987715 0.003363953 2734 tags=41%, list=18%, signal=50%GO_BLASTOCYST_DEVELOPMENT 47 0.53018 1.981405 0.003699871 2294 tags=38%, list=15%, signal=45%GO_MHC_PROTEIN_COMPLEX 25 0.617111 1.9786 0.003861722 4389 tags=68%, list=30%, signal=96%GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 28 0.595792 1.978175 0.003886889 2539 tags=50%, list=17%, signal=60%GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOG 59 0.51093 1.97702 0.003900176 5275 tags=66%, list=36%, signal=102%GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY 163 0.434755 1.97333 0.004011025 4304 tags=52%, list=29%, signal=72%GO_ATP_GENERATION_FROM_ADP 31 0.58406 1.965218 0.004451992 2068 tags=48%, list=14%, signal=56%GO_NEGATIVE_REGULATION_OF_CELL_DIVISION 42 0.543477 1.960403 0.004776797 2778 tags=48%, list=19%, signal=58%GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_ 92 0.470832 1.952475 0.005274523 4397 tags=53%, list=30%, signal=75%GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS 170 0.430901 1.951364 0.005335651 3196 tags=40%, list=22%, signal=50%GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION 33 0.569645 1.951101 0.005323269 2778 tags=52%, list=19%, signal=63%GO_MEIOTIC_CELL_CYCLE_PROCESS 84 0.479981 1.95076 0.0052808 4734 tags=63%, list=32%, signal=92%GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGA 34 0.570221 1.944679 0.005643291 4703 tags=62%, list=32%, signal=90%GO_REGULATION_OF_CHROMOSOME_ORGANIZATION 217 0.412935 1.940324 0.005968813 3101 tags=36%, list=21%, signal=45%GO_MITOTIC_CELL_CYCLE_CHECKPOINT 118 0.446737 1.936766 0.00620982 4244 tags=52%, list=29%, signal=72%GO_CYTOKINESIS 65 0.499648 1.936169 0.006209342 2470 tags=37%, list=17%, signal=44%GO_NUCLEOTIDE_PHOSPHORYLATION 47 0.513379 1.932264 0.006490855 3429 tags=49%, list=23%, signal=63%GO_OXIDOREDUCTASE_COMPLEX 85 0.467599 1.928438 0.006748327 4324 tags=44%, list=29%, signal=61%GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATA 51 0.519661 1.924746 0.007077682 4337 tags=53%, list=29%, signal=75%

GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPH 26 0.585726 1.908522 0.008138795 3213 tags=50%, list=22%, signal=64%GO_CATALYTIC_STEP_2_SPLICEOSOME 86 0.464386 1.907951 0.008113603 3680 tags=44%, list=25%, signal=58%GO_REGULATION_OF_RNA_STABILITY 123 0.435861 1.906145 0.008208764 4532 tags=49%, list=31%, signal=70%GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE 42 0.52189 1.903842 0.00847113 4441 tags=52%, list=30%, signal=75%GO_STRAND_DISPLACEMENT 17 0.657354 1.903384 0.008444214 3521 tags=76%, list=24%, signal=100%GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIO 59 0.494085 1.901772 0.00849265 3595 tags=44%, list=24%, signal=58%GO_DNA_REPAIR 373 0.387481 1.899688 0.008713179 2910 tags=35%, list=20%, signal=43%GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMA 82 0.466626 1.896622 0.008979565 2585 tags=39%, list=17%, signal=47%GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION 366 0.387548 1.893725 0.009249335 3353 tags=36%, list=23%, signal=46%GO_REGULATION_OF_CELL_DIVISION 180 0.413598 1.893461 0.009193401 2778 tags=37%, list=19%, signal=45%GO_SPINDLE_MIDZONE 18 0.640669 1.890374 0.009521869 2449 tags=61%, list=17%, signal=73%GO_GLUCOSE_CATABOLIC_PROCESS 23 0.595127 1.889531 0.009559649 3429 tags=65%, list=23%, signal=85%GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLE 97 0.447645 1.889099 0.009557304 4436 tags=46%, list=30%, signal=66%GO_RESPONSE_TO_AMMONIUM_ION 29 0.566614 1.8861 0.009945842 3793 tags=59%, list=26%, signal=79%GO_DNA_REPAIR_COMPLEX 33 0.547356 1.882816 0.01028175 3086 tags=58%, list=21%, signal=73%GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPT 147 0.418512 1.877398 0.010944219 4397 tags=46%, list=30%, signal=64%GO_ANAPHASE_PROMOTING_COMPLEX 19 0.627302 1.875681 0.011107292 1836 tags=47%, list=12%, signal=54%GO_NUCLEAR_EXPORT 132 0.424093 1.873984 0.011253199 3464 tags=39%, list=23%, signal=51%

GO_REPLISOME 27 0.678611 2.23784 1.33E-04 2915 tags=67%, list=20%, signal=83%GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY 164 0.499077 2.235385 1.29E-04 2623 tags=41%, list=18%, signal=49%GO_MITOTIC_SPINDLE_ORGANIZATION 53 0.596226 2.229397 1.25E-04 938 tags=43%, list=6%, signal=46%GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS 34 0.643133 2.223044 1.52E-04 665 tags=35%, list=4%, signal=37%GO_MITOTIC_CYTOKINESIS 27 0.672667 2.219045 1.48E-04 665 tags=41%, list=4%, signal=43%GO_REGULATION_OF_NUCLEAR_DIVISION 117 0.511252 2.206203 1.72E-04 2778 tags=46%, list=19%, signal=56%GO_CHROMOSOME_CONDENSATION 22 0.698863 2.20421 1.68E-04 2381 tags=59%, list=16%, signal=70%GO_DNA_PACKAGING 111 0.510489 2.194886 1.63E-04 4703 tags=56%, list=32%, signal=81%GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION 230 0.464126 2.18924 1.86E-04 2704 tags=37%, list=18%, signal=45%GO_SOMATIC_CELL_DNA_RECOMBINATION 26 0.676615 2.186795 1.81E-04 2876 tags=65%, list=19%, signal=81%GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZ 158 0.484793 2.181968 1.77E-04 2631 tags=39%, list=18%, signal=46%GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION 29 0.655754 2.180986 1.72E-04 2318 tags=62%, list=16%, signal=73%

NAME SIZE ES NES FDR q-val RANK AT MAX LEADING EDGE



Supplementary Table 4. ContinuedSupplementary Table 4. List of activated pathway in patients with high SUVmax (>9.0) by Gene Set Enrichment Analysis

NAME SIZE ES NES FDR q-val RANK AT MAX LEADING EDGEGO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION 108 0.451421 1.924025 0.007107236 3595 tags=43%, list=24%, signal=56%GO_NADH_METABOLIC_PROCESS 30 0.56575 1.921518 0.007314275 3429 tags=57%, list=23%, signal=74%GO_NEGATIVE_REGULATION_OF_CELL_KILLING 15 0.678176 1.9197 0.007396926 2661 tags=67%, list=18%, signal=81%GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRAN 50 0.516003 1.919177 0.007386225 1836 tags=38%, list=12%, signal=43%GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION 38 0.533257 1.918906 0.007339059 2404 tags=42%, list=16%, signal=50%GO_SPINDLE_CHECKPOINT 20 0.637176 1.918488 0.007328777 2585 tags=55%, list=17%, signal=67%GO_IMMUNOGLOBULIN_PRODUCTION 34 0.562338 1.914158 0.007678179 3090 tags=44%, list=21%, signal=56%GO_MICROTUBULE_BASED_PROCESS 335 0.390403 1.912349 0.007860475 2704 tags=31%, list=18%, signal=37%GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS 23 0.598738 1.911379 0.007934153 2876 tags=52%, list=19%, signal=65%GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT 25 0.58969 1.910076 0.00799809 4304 tags=72%, list=29%, signal=101%GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPH 26 0.585726 1.908522 0.008138795 3213 tags=50%, list=22%, signal=64%GO_CATALYTIC_STEP_2_SPLICEOSOME 86 0.464386 1.907951 0.008113603 3680 tags=44%, list=25%, signal=58%GO_REGULATION_OF_RNA_STABILITY 123 0.435861 1.906145 0.008208764 4532 tags=49%, list=31%, signal=70%GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE 42 0.52189 1.903842 0.00847113 4441 tags=52%, list=30%, signal=75%GO_STRAND_DISPLACEMENT 17 0.657354 1.903384 0.008444214 3521 tags=76%, list=24%, signal=100%GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIO 59 0.494085 1.901772 0.00849265 3595 tags=44%, list=24%, signal=58%GO_DNA_REPAIR 373 0.387481 1.899688 0.008713179 2910 tags=35%, list=20%, signal=43%GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMA 82 0.466626 1.896622 0.008979565 2585 tags=39%, list=17%, signal=47%GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION 366 0.387548 1.893725 0.009249335 3353 tags=36%, list=23%, signal=46%GO_REGULATION_OF_CELL_DIVISION 180 0.413598 1.893461 0.009193401 2778 tags=37%, list=19%, signal=45%GO_SPINDLE_MIDZONE 18 0.640669 1.890374 0.009521869 2449 tags=61%, list=17%, signal=73%GO_GLUCOSE_CATABOLIC_PROCESS 23 0.595127 1.889531 0.009559649 3429 tags=65%, list=23%, signal=85%GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLE 97 0.447645 1.889099 0.009557304 4436 tags=46%, list=30%, signal=66%GO_RESPONSE_TO_AMMONIUM_ION 29 0.566614 1.8861 0.009945842 3793 tags=59%, list=26%, signal=79%GO_DNA_REPAIR_COMPLEX 33 0.547356 1.882816 0.01028175 3086 tags=58%, list=21%, signal=73%GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPT 147 0.418512 1.877398 0.010944219 4397 tags=46%, list=30%, signal=64%GO_ANAPHASE_PROMOTING_COMPLEX 19 0.627302 1.875681 0.011107292 1836 tags=47%, list=12%, signal=54%GO_NUCLEAR_EXPORT 132 0.424093 1.873984 0.011253199 3464 tags=39%, list=23%, signal=51%GO_REGULATION_OF_CHROMATIN_SILENCING 17 0.632045 1.871112 0.011577061 2314 tags=53%, list=16%, signal=63%GO_COP9_SIGNALOSOME 31 0.550889 1.869737 0.011776852 4082 tags=58%, list=28%, signal=80%GO_POSITIVE_REGULATION_OF_CELL_CYCLE 238 0.395368 1.868333 0.01188478 2700 tags=33%, list=18%, signal=40%GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_P 16 0.65699 1.868035 0.011821872 1107 tags=38%, list=7%, signal=40%GO_REGULATION_OF_DNA_BINDING 64 0.476662 1.867351 0.011862382 3323 tags=44%, list=22%, signal=56%GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_P 16 0.643346 1.866595 0.011895124 2625 tags=44%, list=18%, signal=53%GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY 167 0.41444 1.865663 0.011962856 4397 tags=47%, list=30%, signal=66%GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING 17 0.634196 1.863314 0.012243621 2764 tags=53%, list=19%, signal=65%GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRO 18 0.623772 1.86326 0.012187533 2401 tags=50%, list=16%, signal=60%GO_MICROTUBULE 267 0.392036 1.861141 0.012372167 2580 tags=30%, list=17%, signal=36%GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_P 240 0.394177 1.860418 0.012421226 4284 tags=45%, list=29%, signal=62%GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE 165 0.409863 1.860364 0.012351089 4529 tags=45%, list=31%, signal=65%GO_ADP_METABOLIC_PROCESS 38 0.525642 1.851923 0.013734726 2068 tags=42%, list=14%, signal=49%GO_PEPTIDE_ANTIGEN_BINDING 25 0.571749 1.8481 0.014343379 2971 tags=52%, list=20%, signal=65%GO_MITOCHONDRIAL_PROTEIN_COMPLEX 122 0.420441 1.847359 0.014370341 4324 tags=43%, list=29%, signal=61%GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRAN 123 0.422076 1.846703 0.014363645 2642 tags=36%, list=18%, signal=43%GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZAT 117 0.428163 1.846221 0.014370613 4757 tags=51%, list=32%, signal=75%GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING 81 0.450062 1.84605 0.014297308 3337 tags=40%, list=22%, signal=51%GO_PROTEIN_HYDROXYLATION 17 0.642743 1.845049 0.014364667 3144 tags=65%, list=21%, signal=82%GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY 118 0.426147 1.843878 0.014549865 4397 tags=47%, list=30%, signal=66%GO_DOUBLE_STRAND_BREAK_REPAIR 115 0.432275 1.843771 0.014469997 2841 tags=39%, list=19%, signal=48%GO_RNA_LOCALIZATION 157 0.406711 1.839622 0.015146831 4331 tags=46%, list=29%, signal=65%GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITI 40 0.513857 1.834408 0.015907375 2642 tags=40%, list=18%, signal=49%GO_CHROMATIN_REMODELING 108 0.425923 1.8338 0.01589863 4869 tags=53%, list=33%, signal=78%GO_REGULATION_OF_CENTROSOME_DUPLICATION 24 0.586884 1.8309 0.016407663 2935 tags=54%, list=20%, signal=67%GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE 163 0.405985 1.829528 0.016586382 3197 tags=39%, list=22%, signal=49%GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISIO 27 0.562542 1.829061 0.016604494 2778 tags=52%, list=19%, signal=64%GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUC 50 0.480645 1.828213 0.016716253 3213 tags=40%, list=22%, signal=51%GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACT 28 0.556799 1.827418 0.016783293 2615 tags=46%, list=18%, signal=56%GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS 188 0.394424 1.825955 0.016954983 3193 tags=35%, list=22%, signal=44%GO_CENTRIOLE 63 0.462167 1.823001 0.017649602 1465 tags=30%, list=10%, signal=33%GO_MULTI_ORGANISM_LOCALIZATION 62 0.46523 1.820057 0.01822622 3064 tags=44%, list=21%, signal=55%GO_TELOMERE_ORGANIZATION 73 0.458404 1.819523 0.01820337 2739 tags=38%, list=18%, signal=47%GO_MRNA_BINDING 124 0.412686 1.819069 0.018199239 4201 tags=44%, list=28%, signal=61%GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS 116 0.415723 1.818751 0.018189065 3793 tags=46%, list=26%, signal=61%GO_DNA_DEPENDENT_ATPASE_ACTIVITY 61 0.471764 1.818343 0.018191142 3101 tags=44%, list=21%, signal=56%GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RR 33 0.52658 1.812463 0.019324034 4201 tags=52%, list=28%, signal=72%GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 102 0.431496 1.808917 0.020089041 4869 tags=50%, list=33%, signal=74%GO_POSITIVE_REGULATION_OF_CYTOKINESIS 18 0.600906 1.80787 0.02018635 2470 tags=50%, list=17%, signal=60%GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO 30 0.544106 1.807308 0.020217644 3213 tags=47%, list=22%, signal=59%GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION 144 0.406836 1.807137 0.020126734 2691 tags=33%, list=18%, signal=39%GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE 87 0.432174 1.805685 0.020349115 2700 tags=38%, list=18%, signal=46%GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY 60 0.464108 1.804845 0.02042031 5002 tags=53%, list=34%, signal=80%GO_NIK_NF_KAPPAB_SIGNALING 74 0.44706 1.804008 0.020512544 5275 tags=54%, list=36%, signal=83%GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 223 0.383957 1.800186 0.021287745 4151 tags=46%, list=28%, signal=63%GO_SITE_OF_DOUBLE_STRAND_BREAK 25 0.549674 1.799008 0.021420369 3101 tags=44%, list=21%, signal=56%GO_ENDORIBONUCLEASE_ACTIVITY 42 0.502646 1.798836 0.021337252 1837 tags=33%, list=12%, signal=38%GO_CELLULAR_GLUCURONIDATION 17 0.623589 1.798543 0.021282895 3688 tags=71%, list=25%, signal=94%




NAME SIZE ES NES FDR q-val RANK AT MAX LEADING EDGEGO_INTERSTRAND_CROSS_LINK_REPAIR 34 0.5182 1.793112 0.022627989 2642 tags=47%, list=18%, signal=57%GO_REGULATION_OF_INTERLEUKIN_1_SECRETION 20 0.575016 1.790128 0.023342606 2401 tags=45%, list=16%, signal=54%GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST 71 0.445314 1.790057 0.023234114 2494 tags=35%, list=17%, signal=42%GO_MITOCHONDRION_ORGANIZATION 492 0.357751 1.789685 0.0232417 4353 tags=41%, list=29%, signal=56%GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY 122 0.409856 1.787912 0.023587052 4176 tags=45%, list=28%, signal=62%GO_G1_DNA_DAMAGE_CHECKPOINT 64 0.450682 1.787806 0.023495499 2494 tags=38%, list=17%, signal=45%GO_AGING 188 0.392037 1.786813 0.023668915 3105 tags=35%, list=21%, signal=44%GO_NEGATIVE_REGULATION_OF_CELL_CYCLE 337 0.365155 1.786397 0.023647262 3199 tags=36%, list=22%, signal=44%GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDO 15 0.637975 1.785451 0.023871046 4520 tags=73%, list=30%, signal=105%GO_MEIOSIS_I 44 0.487539 1.784974 0.023849044 1974 tags=39%, list=13%, signal=44%GO_ANTIGEN_PROCESSING_AND_PRESENTATION 168 0.390585 1.78457 0.02381657 4520 tags=45%, list=30%, signal=64%GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PRO 237 0.37892 1.783659 0.023910353 4397 tags=45%, list=30%, signal=63%GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY 147 0.397895 1.783161 0.023883766 4397 tags=46%, list=30%, signal=64%GO_DNA_GEOMETRIC_CHANGE 70 0.447886 1.783117 0.023773609 3134 tags=44%, list=21%, signal=56%GO_URONIC_ACID_METABOLIC_PROCESS 21 0.58919 1.782887 0.023736905 3688 tags=67%, list=25%, signal=89%GO_KERATINOCYTE_DIFFERENTIATION 44 0.483066 1.78163 0.023860693 4047 tags=48%, list=27%, signal=65%GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PRO 15 0.634233 1.780746 0.024003105 1825 tags=40%, list=12%, signal=46%GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION 94 0.428975 1.779126 0.024343934 4980 tags=51%, list=34%, signal=76%GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCES 51 0.474635 1.775822 0.0252352 2068 tags=35%, list=14%, signal=41%GO_BASE_EXCISION_REPAIR 33 0.518781 1.775008 0.025333414 1453 tags=30%, list=10%, signal=34%GO_MAGNESIUM_ION_BINDING 146 0.399748 1.769566 0.026884038 3448 tags=39%, list=23%, signal=50%GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT 85 0.435762 1.769082 0.026944254 2642 tags=38%, list=18%, signal=46%GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_ 27 0.533529 1.768532 0.027018279 2661 tags=48%, list=18%, signal=59%GO_MICROTUBULE_END 19 0.587071 1.768201 0.027002487 1839 tags=42%, list=12%, signal=48%GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS 197 0.379032 1.768095 0.026922613 3780 tags=38%, list=25%, signal=50%GO_CELLULAR_RESPONSE_TO_LIPID 302 0.370141 1.7667 0.027177107 3647 tags=38%, list=25%, signal=50%GO_NUCLEASE_ACTIVITY 147 0.391192 1.765878 0.027287431 3213 tags=35%, list=22%, signal=45%GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_ 30 0.533204 1.763445 0.027930625 4596 tags=60%, list=31%, signal=87%GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZA 78 0.434254 1.760367 0.02876248 3086 tags=40%, list=21%, signal=50%GO_RESPONSE_TO_BACTERIUM 327 0.362193 1.756208 0.029923374 4156 tags=44%, list=28%, signal=59%GO_DNA_HELICASE_ACTIVITY 41 0.496885 1.755872 0.029932559 3134 tags=49%, list=21%, signal=62%GO_RESPONSE_TO_RADIATION 269 0.368712 1.75442 0.030261595 2887 tags=34%, list=19%, signal=42%GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TR 18 0.592328 1.753865 0.030259741 1636 tags=39%, list=11%, signal=44%GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION 43 0.483535 1.753115 0.030291077 3086 tags=44%, list=21%, signal=56%GO_REGULATION_OF_CELL_CYCLE_ARREST 87 0.426207 1.751336 0.030777855 2494 tags=32%, list=17%, signal=38%GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 56 0.458237 1.749956 0.031073641 4201 tags=46%, list=28%, signal=65%GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING 23 0.558286 1.745239 0.03264952 2318 tags=48%, list=16%, signal=57%GO_TRNA_METABOLIC_PROCESS 155 0.388146 1.743441 0.03308701 3400 tags=34%, list=23%, signal=44%GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_O 15 0.609709 1.741365 0.033677634 4408 tags=73%, list=30%, signal=104%GO_CELLULAR_COMPONENT_DISASSEMBLY 411 0.352138 1.740196 0.03393662 4353 tags=43%, list=29%, signal=59%GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPR 368 0.353778 1.739656 0.034019563 4580 tags=42%, list=31%, signal=60%GO_PROTEIN_K11_LINKED_UBIQUITINATION 25 0.544004 1.739065 0.034028664 1836 tags=36%, list=12%, signal=41%GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCE 31 0.515089 1.738847 0.033974387 1957 tags=32%, list=13%, signal=37%GO_RESPONSE_TO_ANTIBIOTIC 35 0.494587 1.735688 0.034845974 2884 tags=43%, list=19%, signal=53%GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY 23 0.55093 1.735024 0.034950186 1777 tags=35%, list=12%, signal=39%GO_MATURATION_OF_SSU_RRNA 41 0.480742 1.734585 0.035035875 4201 tags=49%, list=28%, signal=68%GO_ENDONUCLEASE_ACTIVITY 87 0.42155 1.734515 0.034902167 3213 tags=38%, list=22%, signal=48%GO_SPERM_PART 59 0.446499 1.733244 0.035147224 1944 tags=29%, list=13%, signal=33%GO_RIBONUCLEASE_ACTIVITY 79 0.428211 1.732588 0.0352488 3213 tags=37%, list=22%, signal=47%GO_HELICASE_ACTIVITY 120 0.395392 1.732326 0.035221428 3134 tags=37%, list=21%, signal=46%GO_NUCLEAR_TRANSPORT 296 0.359154 1.732055 0.035168093 3595 tags=35%, list=24%, signal=45%GO_KINESIN_COMPLEX 31 0.510156 1.731647 0.03521115 593 tags=26%, list=4%, signal=27%GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPT 82 0.420734 1.731565 0.035088576 4513 tags=50%, list=30%, signal=71%GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PR 118 0.393275 1.730806 0.03520113 4337 tags=41%, list=29%, signal=57%GO_NAD_METABOLIC_PROCESS 46 0.473373 1.730402 0.035225857 3429 tags=46%, list=23%, signal=59%GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS 20 0.573889 1.727758 0.035976026 1825 tags=35%, list=12%, signal=40%GO_REGULATION_OF_CIRCADIAN_RHYTHM 63 0.44227 1.727401 0.035967782 2651 tags=37%, list=18%, signal=44%GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLIC 17 0.586702 1.72321 0.03744035 4645 tags=71%, list=31%, signal=103%GO_PYRUVATE_METABOLIC_PROCESS 50 0.460126 1.722612 0.0374893 3429 tags=50%, list=23%, signal=65%GO_CHROMATIN_BINDING 303 0.357178 1.717366 0.039463993 3217 tags=32%, list=22%, signal=40%GO_MICROTUBULE_ORGANIZING_CENTER_PART 97 0.409008 1.717298 0.039340846 1944 tags=31%, list=13%, signal=35%GO_U1_SNRNP 17 0.596566 1.714583 0.040399984 1692 tags=35%, list=11%, signal=40%GO_PROTEIN_DNA_COMPLEX 97 0.406926 1.713297 0.040770542 3197 tags=36%, list=22%, signal=46%GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS 65 0.441097 1.712895 0.04075552 2068 tags=32%, list=14%, signal=37%GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA 92 0.410322 1.710585 0.041518483 3055 tags=36%, list=21%, signal=45%GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDEN 127 0.388486 1.71013 0.04154587 4337 tags=46%, list=29%, signal=64%GO_SUPRAMOLECULAR_FIBER 370 0.351778 1.707702 0.042521853 2580 tags=28%, list=17%, signal=33%GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION 94 0.405297 1.706686 0.0428484 3101 tags=38%, list=21%, signal=48%GO_POSTREPLICATION_REPAIR 46 0.466744 1.706508 0.042731747 2585 tags=41%, list=17%, signal=50%GO_RESPONSE_TO_X_RAY 22 0.553637 1.705689 0.042847447 2846 tags=36%, list=19%, signal=45%GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE 48 0.460191 1.705119 0.04295782 4384 tags=50%, list=30%, signal=71%GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX 36 0.483551 1.70402 0.043253396 1293 tags=28%, list=9%, signal=30%GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONS 31 0.49819 1.703452 0.04334151 3642 tags=48%, list=25%, signal=64%GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT 41 0.472192 1.703361 0.043213446 2494 tags=37%, list=17%, signal=44%GO_NECROTIC_CELL_DEATH 25 0.528053 1.702995 0.043237716 799 tags=20%, list=5%, signal=21%GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION 31 0.503359 1.702572 0.043217897 2846 tags=42%, list=19%, signal=52%GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY 289 0.35393 1.702368 0.043139182 4513 tags=43%, list=30%, signal=60%

GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_P 47 0.458467 1.682281 0.048531007 4329 tags=47%, list=29%, signal=66%GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 61 0.428813 1.682092 0.048454694 4861 tags=52%, list=33%, signal=78%GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 247 0.356242 1.681883 0.048371475 3596 tags=35%, list=24%, signal=46%GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT 70 0.422366 1.68071 0.04873936 4914 tags=53%, list=33%, signal=79%GO_MICROTUBULE_MOTOR_ACTIVITY 36 0.475007 1.680623 0.04861596 593 tags=25%, list=4%, signal=26%GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINAS 78 0.410243 1.680305 0.048586965 3492 tags=42%, list=24%, signal=55%GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS 19 0.560025 1.680281 0.048433214 3429 tags=63%, list=23%, signal=82%GO_FC_RECEPTOR_SIGNALING_PATHWAY 175 0.366731 1.680255 0.048276924 5275 tags=53%, list=36%, signal=81%GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION 63 0.431248 1.678986 0.0487309 3197 tags=35%, list=22%, signal=44%




NAME SIZE ES NES FDR q-val RANK AT MAX LEADING EDGEGO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CE 19 0.558881 1.701797 0.043225512 1734 tags=26%, list=12%, signal=30%GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGAT 22 0.547358 1.701368 0.043209724 2653 tags=50%, list=18%, signal=61%GO_RIBOSOME_BINDING 38 0.477521 1.700826 0.04328843 3337 tags=50%, list=22%, signal=64%GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY 19 0.561416 1.700236 0.043413073 2739 tags=47%, list=18%, signal=58%GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMER 48 0.45419 1.698675 0.043994468 4742 tags=67%, list=32%, signal=98%GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PA 37 0.482083 1.698627 0.043860547 2186 tags=30%, list=15%, signal=35%GO_PROSTANOID_METABOLIC_PROCESS 22 0.540476 1.697084 0.044346824 4204 tags=59%, list=28%, signal=82%GO_CELLULAR_SENESCENCE 25 0.533696 1.696717 0.044342577 2895 tags=44%, list=20%, signal=55%GO_PRERIBOSOME 59 0.444364 1.694774 0.045018245 5339 tags=58%, list=36%, signal=90%GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITIO 122 0.387392 1.694397 0.045045882 2623 tags=32%, list=18%, signal=39%GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS 195 0.366112 1.694313 0.04494094 3213 tags=34%, list=22%, signal=43%GO_MITOTIC_SPINDLE 41 0.471716 1.69292 0.04540238 3185 tags=46%, list=21%, signal=59%GO_REGULATION_OF_DNA_METABOLIC_PROCESS 258 0.357353 1.69283 0.045281667 3197 tags=36%, list=22%, signal=45%GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING 18 0.574148 1.692289 0.045375437 4331 tags=61%, list=29%, signal=86%GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS 104 0.393382 1.692208 0.04524094 3548 tags=38%, list=24%, signal=50%GO_RESPIRATORY_CHAIN 74 0.430297 1.691765 0.045289762 4324 tags=42%, list=29%, signal=59%GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGAT 21 0.538651 1.690305 0.045760605 2585 tags=48%, list=17%, signal=58%GO_B_CELL_ACTIVATION 78 0.411709 1.688135 0.046620738 2946 tags=35%, list=20%, signal=43%GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONS 189 0.367137 1.688101 0.046469014 4529 tags=42%, list=31%, signal=59%GO_REGULATION_OF_LEUKOCYTE_MIGRATION 112 0.390678 1.686073 0.04716464 4024 tags=46%, list=27%, signal=63%GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KIN 26 0.529346 1.685924 0.047066994 1628 tags=35%, list=11%, signal=39%GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_P 47 0.458467 1.682281 0.048531007 4329 tags=47%, list=29%, signal=66%GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 61 0.428813 1.682092 0.048454694 4861 tags=52%, list=33%, signal=78%GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 247 0.356242 1.681883 0.048371475 3596 tags=35%, list=24%, signal=46%GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT 70 0.422366 1.68071 0.04873936 4914 tags=53%, list=33%, signal=79%GO_MICROTUBULE_MOTOR_ACTIVITY 36 0.475007 1.680623 0.04861596 593 tags=25%, list=4%, signal=26%GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINAS 78 0.410243 1.680305 0.048586965 3492 tags=42%, list=24%, signal=55%GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS 19 0.560025 1.680281 0.048433214 3429 tags=63%, list=23%, signal=82%GO_FC_RECEPTOR_SIGNALING_PATHWAY 175 0.366731 1.680255 0.048276924 5275 tags=53%, list=36%, signal=81%GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION 63 0.431248 1.678986 0.0487309 3197 tags=35%, list=22%, signal=44%GO_ANTIGEN_BINDING 75 0.412983 1.678523 0.048842497 3915 tags=47%, list=26%, signal=63%GO_ORGANELLE_INNER_MEMBRANE 430 0.337606 1.677468 0.04919663 4462 tags=41%, list=30%, signal=57%GO_REGULATION_OF_GENE_SILENCING 35 0.486706 1.676464 0.04952372 2314 tags=40%, list=16%, signal=47%GO_CONDENSED_NUCLEAR_CHROMOSOME 58 0.442884 1.675297 0.04989431 3196 tags=47%, list=22%, signal=59%GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SI 30 0.49524 1.675121 0.049802527 4329 tags=53%, list=29%, signal=75%



Supplementary Table 5. Significant genes associated with disease-free survivalSupplementary Table 5. Significant genes associated with disease-free survival







































Supplementary Table 6. Significant genes associated with overall survivalSupplementary Table 6. Significant genes associated with overall survival
















Documents

Supplementary Table 1. Detailed clinical informationdc f o · DNAJC7 DnaJ heat shock protein family (Hsp40) member C7(DNAJC7) 0.601 0.003 UQCC2 ubiquinol-cytochrome c reductase complex