Incorporation of Sunnybrook Research Institute

By Stephanie Roberts

On June 28, 2010, the Board of Sunnybrook Health Sciences Centre authorized management to proceed with preliminary work toward the incorporation of Sunnybrook Research Institute (SRI).

“This is an important advance for SRI, one with distinct advan-tages to both the corporation and our research staff,” said Dr. Michael Julius, vice-president of research at Sunnybrook. Julius hosted a town hall meeting earlier that day where Michael Young, executive vice-president and chief administrative executive at Sunnybrook, presented on the initiative.

Young answered a list of anticipated questions about the incor-poration, and took queries from the meeting’s attendees, who came from across the research institute.

“The hospital has considered incorporation of SRI in the past and only now, after identifying compelling reasons, are we pursuing this approach,” said Young.

Primary among those reasons is encouraging further investment in SRI by simplifying the process for “contributors” to take advan-tage of federal tax credits available through the Scientific Re-search and Experimental Development (SR&ED) program, he said.

The SR&ED program is a federal tax incentive program designed to stimulate Canadian businesses to conduct research and devel-

opment (R&D) in Canada. It is the largest single source of federal support for industrial R&D. The program gives claimants cash refunds and tax credits for eligible R&D expenses.

Young noted that one can partake of the SR&ED program without SRI being incorporated, but to do so would require individuals to apply to the Canada Revenue Agency on a project-by-project basis. “Such a process is not considered economically or logisti-cally feasible,” he said.

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SUMMER 2010

4 CV: DR. MARC JESCHKE

6 TRAINEES’ POST

7 APPLAUSE

NEWS @ SRI: Cancer research funding; Centre of Excellence for Research and Commercialization; funding agency news3

2 Sunnybrook Research Institute NEXUS SUMMER 2010

New and NoteworthyIn Depth: Highly Qualified Personnel

Online this summer at Sunnybrook Re-search Institute, we look at highly quali-fied personnel (HQP)—who they are and why they matter. Engineers, physicists, research associates, lab managers, tech-nicians, epidemiologists, coordinators and biostatisticians: these are the staff we feature in a probing series of stories and interviews.

Get a rare glimpse into the working lives of HQP. Learn what they did to get where they are. See how the roles, experiences and achievements of these skilled indi-viduals—critical to the economic health of Ontario and Canada—are fundamental to our success in inventing the future of health care.

www.sunnybrook.ca/research

Continued from page 1

Incorporation will streamline the pro-cess. That’s because, owing to its single focus—research—SRI will be eligible to apply for preapproved status, something the hospital with its diversity of activity cannot do. Once SRI receives this status, all contributions to SRI will be eligible for SR&ED credits.

Another compelling reason to incorporate is that researchers will be able to receive grants now beyond their grasp. These are funds administered by federal agencies that require the recipient organization to be compliant with the Employment Equity Act, legislation to ensure equal employ-ment opportunities for women, Aboriginal peoples, persons with disabilities and visible minorities.

“It is not feasible for Sunnybrook to be compliant with the act—indeed, we are not aware that any of our peer hospitals meet the employment equity require-ment,” said Young. With incorporation, SRI will become the first among its academic health sciences centre peers to meet the legislative mandate. This means researchers here will be able to hold grants from the Public Health Agency of Canada, for example.

A third reason, said Young, is that SRI will no longer be viewed as a depart-ment of the hospital, which is currently how it is structured; this may create new “branding” opportunities for SRI. He also emphasized that the transition will be “seamless.” All staff at SRI will be transferred into the new incorporated structure. There will be no impact on existing payroll, benefits or pensions; and incorporation will not change how researchers apply for grants.

Legally, SRI will become a separate not-for-profit non-share capital charitable organization and a wholly owned subsid-iary of Sunnybrook. Operationally, board governance will remain the same, with David Leslie at the helm, as he is now. Dr. Barry McLellan, president and CEO of Sunnybrook, will retain this position for SRI, and Julius will remain as vice-president, research.

Operational details are expected to be finalized by January 1, 2011.

Questions? Go to the SRI section of the Intranet (Sunnynet), located under Education and Research. A section on incorporation has been created under News and Updates. There, you can read FAQs and submit your own.

U.S. Company Buys SRI Spin-Off

From discovery through to clinical impact: this is the mandate of Sunnybrook Research Institute (SRI), and we’re achieving it. SonoSite Inc., a world leader in bedside and point-of-care ultrasound based in Bothell, Washington, has signed a definitive agreement to acquire SRI start-up company VisualSonics Inc., which began in the lab of Dr. Stuart Foster. In the 1990s, Foster invented high-frequency micro-ultrasound, an imaging tool that made tiny physiological details, such as the blood flow feeding a mouse tumour, visible. It enabled more mice to be scanned, more drugs to be tested and more disease to be researched. Demand for this technology was so great that Foster commercialized it and formed VisualSonics Inc. in 1999. Since then, the device has had extensive impact. Leading universities, medical centres and pharmaceuti-cal companies—more than 600 worldwide—use it for their research, across many domains of investigation, including cardiac, cancer and regenerative medicine.

Upon finalization of the acquisition, SonoSite will continue expanding into pre-clinical markets, and will extend the technology to an array of clinical markets and applications, such as diagnostic radiology, neonatology, pediatric cardiology, orthopedic medicine, tissue regeneration, and dermatology for cosmetic and clinical disease management.

3 Sunnybrook Research Institute NEXUS SUMMER 2010

Province Rewards SRI Researchers

Three Sunnybrook Research Institute (SRI) scientists will receive funding from the Ontario Institute for Cancer Research (OICR) for operating costs and state-of-the-art equipment.

The OICR will invest $250,000 in the One Millimetre Cancer Challenge, led by SRI senior imaging scientist Dr. Martin Yaffe. The funds, which will be divided among five research sites,

will go toward equipment that will further research into the early detection of tumours using advanced imaging and screening techniques. Sunnybrook’s share of the award is $43,000.

Yaffe also co-leads the OICR’s Imaging Pipeline Platform, a program aimed at developing new tools to diagnose and treat cancer, and moving them quickly into the clinic for the benefit of patients. The OICR awarded $218,000 in support of the pro-gram, of which $98,000 will go to SRI.

Dr. Craig Earle, who leads the OICR/Cancer Care Ontario Health Services Research Program, will receive $102,000 to purchase computer servers and related equipment to host the Ontario Cancer Data Linkage Project. This initiative will give researchers access to customized and anonymized data sets of Ontario cancer patients that will enable them to study the orga-nization and delivery of cancer services across the province.

Finally, the OICR awarded senior scientist Dr. Bob Kerbel $608,443 in its latest grant competition. He will use the funds to develop preclinical research strategies to improve the clinical success of antiangiogenic adjuvant therapies.

News @ SRI

Funding Agency News

The Canada Foundation for Innovation (CFI) has named a new president and CEO to succeed Dr. Eliot Phillipson, whose six-year run ended June 30. Dr. Gilles Patry will take over on Aug. 1, 2010. No news yet on the competition dates for the CFI’s flagship funds, the New Initiatives Fund and Leading Edge Fund. Rumour has it that we’ll see a launch by year’s end. Stay tuned.

Kiss those thoughts of a lazy summer goodbye: the Ministry of Research and Innovation has announced a new suite of competitions, including the Ontario Research Fund-Research Excellence program. Notices of intent are due July 30, 2010; full proposals, Oct. 29, 2010. The ministry also launched the next round of its Early Researcher Award program, with a Sept. 20, 2010 deadline. For more, visit the funding section of SRI’s website: www.sunnybrook.ca/research.

An Excellent Proposal

Sunnybrook Research Institute (SRI) has been successful in the first stage of its bid to establish a $30-million Centre for Imaging Technology Commercialization and Research (CITCR) through the federal government’s Centres of Excellence for Commercial-ization and Research (CECR) program.

In February 2010, the SRI team, led by Dr. Martin Yaffe, senior scientist in imaging, submitted a letter of intent jointly with the University of Western Ontario. Upon its review, the team was invited to advance to the second stage—full application—one of only 10 teams thus invited.

If funded, the CITCR will establish incubator nodes at SRI and Western, along with an expert business office charged with de-veloping the commercial potential of tools and devices emerging from research. It will fill a gap in the research-to-market con-tinuum between the labs and the activities of MaRS Innovation, SRI’s partner in tech transfer.

The government has earmarked $57 million for this competition. The CECR program aims to create globally renowned hubs of commercialization and research expertise in the Canadian gov-ernment’s priority areas. Up to four new national centres of excel-lence will be created. Results are expected in December 2010.

Cancer Researchers Get Funds

Four Sunnybrook Research Insti-tute cancer researchers have been awarded grants by the Canadian Cancer Society Research Institute (CCSRI) and the Canadian Breast Cancer Foundation. Over $1.4 million in grants were awarded by CCSRI to four scientists in the Odette Cancer Research Program through its Octo-ber 2009 competition.

Dr. Lisa Barbera, a scientist in clinical epidemiology, will re-ceive $352,243 over three years to conduct a population-based analysis of vulvar carcinoma.

Dr. Bob Kerbel, a senior scientist in molecular and cellular biology, will receive $427,500 over three years for his research on metronomic chemotherapy and antiangiogenic drugs.

Dr. Martin Yaffe, a senior imaging scientist, will receive $313,066 over three years for his research on improving the ac-curacy of breast cancer detection with digital tomosynthesis.

Dr. Greg Czarnota, an imaging scientist, will receive $389,532 over three years to investigate ultrasound-activated microbub-ble enhancement of response to radiation therapy.

Czarnota was also awarded a grant worth $302,990 over three years by the Canadian Breast Cancer Foundation, for his re-search on optical spectroscopy for improving chemotherapy.

CIHR Gives Nod to Sunnybrook-Led Team

The Canadian Institutes of Health Research (CIHR) has awarded $2.7 million over three years to a team of researchers led by clinician-scientist Dr. Greg Czarnota. The award is a team grant made through CIHR’s Terry Fox New Frontiers Program in Cancer. It will support the group’s development of ultrasound methods to monitor the effects of cancer therapies on cell death. Czarnota and colleagues will also work to develop new ultrasound-based therapeutics to improve conventional cancer treatments.

Dr. Martin Yaffe

Dr. Greg Czarnota

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Tool Kit: BD FACSAria II Upgrade

The BD Biosciences FACSAria II is a cell sorter that provides data and separates cells based on phenotype and other morphologi-cal characteristics. Molecular and cellular biology researchers at Sunnybrook Research Institute (SRI) use the system, which is housed in the institute’s Centre for Cytometry and Scanning Microscopy, to extract cell subsets from a wide range of cellular

information, including antigen expression, morphology, DNA and RNA content, chromosomal composition and protein expres-sion. A high-throughput instrument, the FACSAria II will sort and analyze up to 35,000 cells per second.

In April 2010, BD Biosciences upgraded the cell sorter, a $100,000 enhancement. “The exterior is the same, but the inside has been gutted and replaced with new pieces,” says Gisele Knowles, who manages the centre. Gone are the fluidics valves that sometimes stuck, resulting in lost cells and system down-time. The new valves, the design of which returns to the previous generation of valves, are part of a revamped automated cleaning program that keeps the system’s internal components free of cor-rosive elements. Also new is the geometry of the fluidics nozzle that corrals the cells into a single-file stream suitable for laser-light illumination. An improved nozzle insertion design enables secure, rapid nozzle size changes for different cell sorts.

“This upgrade is a win-win for the facility and users,” says Knowles. “We can re-sterilize the equipment and service users more efficiently, and users can change sort applications on the fly and keep the efficiency they’ve come to expect from this system.”

The Canada Foundation for Innovation funded SRI’s initial pur-chase of the FACSAria II.

CV: Dr. Marc JeschkeBio basics: Medical director of the Ross Tilley Burn Centre at Sun-nybrook, senior scientist in SRI’s Trauma, Emergency & Critical Care Research Program and associate professor of surgery at the University of Toronto. Arrived in May 2010 from Shriners Burns Hospital for Chil-dren. Received MD from Eberhard Karls University, master of medical science from the University of Texas and PhD from the University of Re-gensburg, Germany.

What brought you here from the U.S.?

The Toronto burn unit is a well-known burn centre—the largest in Canada. Paired with opportunities at Sunnybrook Research Institute to establish a translational scientific program, it was an outstanding offer.

Tell me about your current research.

Our research focuses on stress. Of course, burn plays an im-portant role, but we also look at other factors, such as endotox-emia, sepsis and surgical stress. We look at the inflammatory or stress-induced cellular changes. The focus is on how to improve outcomes for burn patients by attenuating this dramatic or vast inflammatory response. In severely burned patients, they lose all their muscle. They’re really sick.

What are the most rewarding parts of your work?

I’m a very big supporter of clinical translation science. So, I do clinical research, but I also do basic science research in cell cul-tures, with preclinical models. When you operate [on patients] or

do patient care, questions can arise that have not been answered in the literature. The benefit of being an academic clinician is that you are able to think about the questions, educate yourself and then ask, “Is this important enough to design an experiment around?” My fascination is driven by saving patients’ lives, based not only on what is known, but also on what can be discovered.

What do you do outside of work?

I have a big family—I’m married, have four children and a dog. That’s the centre of my life as well. In whatever time is left, I enjoy literature, music, opera and the symphony. I try to conduct sports and get outdoors.

Have you found any new hobbies in Canada?

Not yet—I’m sure it will come! The outdoors here are very beauti-ful. Of course, I like good food.

Toronto is pretty good for that.

Oh, yeah. Fantastic, fantastic food.

Gisele Knowles, manager of SRI’s Centre for Cytometry and Scan-ning Microscopy, operates the upgraded BD FACSAria II cell sorter

PEOPLE @ SRINewly Appointed:

Dr. Paul Binhammer, CE, TECC (associate scientist)Dr. Saulo Castel, CE, Brain Sciences (associate scientist)Dr. Simon Graham, Imaging, Brain Sciences (senior scientist)Dr. Marc Jeschke, MCB, TECC (senior scientist)Dr. Laurent Milot, Imaging, Cancer (associate scientist)Dr. Helen Razmjou, CE, MSK (associate scientist)

Moving Within SRI:

Dr. Eugene Crystal, Imaging, CardiacDr. Nick Daneman, CE, TECC

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Government Investment Puts State-of-the-Art Tools in Hands of SRI ScientistsBy Alisa Kim

The Canada Foundation for Innovation, the country’s largest funding agency for research infrastructure, has awarded $771,586 to three Sunnybrook Research Institute (SRI) scientists through its Lead-ers Opportunity Fund.

The program aims to help Canadian universities attract and retain world-class researchers by providing faculty with the fundamentals to carry out cutting-edge research. The award is matched dollar for dollar by the province’s Ministry of Research and Innovation, bringing total funding awarded to $1.5 million. The grants will pay for the equipment, build-ings, laboratories and databases required to conduct research, in contrast to oper-ating grants, which support day-to-day costs of running a lab.

“Technology is everything in this field,” says Dr. Jonathan Rast, a scientist in molecu-lar and cellular biology at SRI and one of the three award recipients. “Different labs around the world complement each other, but you can have a situation where other labs can do things more efficiently than you. You run the risk of having as good an idea as everyone else, but they’re the ones doing interesting stuff because they have the equipment to do it and you don’t.”

Rast, who is also a professor in medical biophysics at the University of Toronto, is studying how genes operate in the im-mune response of the purple sea urchin, whose immune system bears similarities to our own. He will use the award, worth $117,435, to examine how the microbial environment of the sea urchin gut is con-trolled by its immune system.

“The grant provides us with microscopy equipment that we’ll use to film immune re-actions in the [urchin] larvae. We can watch all the cells in the organism, and how they behave in response to an immune reaction. It also gives us equipment that allows us to quantify gene activity; we can watch how genes go on and off during the course of a simple immune response,” says Rast.

His colleague, Dr. Bojana Stefanovic, an imaging scientist at SRI and a professor in medical biophysics at U of T, seeks to understand the link between brain function and the vascular state. She was awarded $254,151, the bulk of which she’ll use to buy the latest two-photon fluorescence scanning laser microscope so that she can study how fine blood vessels in the brain support abnormal activity in preclinical models of Alzheimer’s disease.

“The microscope allows imaging not just of the surface of the brain, but up to one millimetre below the surface; relative to other optical microscopy methods, that’s quite deep,” says Stefanovic. “We can look at the effect, in real time, of neuronal firing patterns on the smallest brain ves-sels. It’s a very powerful platform for doing investigation into brain function.”

In addition to furthering her own work, Stefanovic says acquiring the equipment will stimulate collaborative research: “A unique strength of this infrastructure is that it complements a lot of the imag-ing systems we already have at SRI. It brings a new type of information to our studies, not just in my work, but in oth-ers’ work as well—at SRI and among our colleagues downtown.”

The third of SRI’s Leaders Opportunity Fund award winners is Dr. Marc Jeschke. Recruited from the Shriners Burns Hos-pital for Children and University of Texas Medical Branch, Jeschke joined SRI in May as a senior scientist in the Trauma, Emergency & Critical Care Research Program. He is also the medical director of the Ross Tilley Burn Centre at Sunnybrook and a professor in surgery at U of T.

Jeschke aims to determine what causes stress-induced diabetes. Specifically, he will look at how burns cause cellular changes that lead to dysfunction in how the liver metabolizes glucose.

He will receive $400,000, which will en-able him to establish his laboratory and purchase an imaging system that lets him study changes in cell organelles that pro-duce insulin resistance in the body.

“I’m very honoured and humbled,” says Jeschke of the award. “It opens the doors to start my research in partnership with many outstanding scientists at SRI. We have a unique setup here at Sunnybrook with the burn unit, the critical care facilities and the division of plastic surgery, all of which gives us patient access. The award is wonderful for the group.”

Dr. Jonathan Rast is one of three scientists at SRI to receive an award from the Canada Foundation for Innovation through its Leaders Opportunity Fund

6 Sunnybrook Research Institute NEXUS SUMMER 2010

What is your background and research focus?

I took biochemistry as an undergraduate student at the University of Waterloo. I started in a master’s program at the department of laboratory medicine and pathobiology at U of T, and last summer I transferred to the PhD program. The focus of my thesis is on the use of ultrasound technology to deliver a therapeutic agent to the brain in a preclinical model of Alzheimer’s disease.

When did you find out your paper was accepted and what was your reaction?

I found out around mid-April that it was accepted. I was really excited, and it felt so good because it took a lot of work to get that paper out. I worked so hard on this—going to conferences and presenting it—and we went through so many drafts of the paper. It was such a great feeling to finally have it published and out there for people to read.

Was there anything you found surprising?

I didn’t expect reviewers to sometimes be as negative as they are. Sometimes they give constructive feedback, but it can sound harsh and negative. I think people who’ve been doing this for a long time get used to it. Over time I may grow a thicker skin. I know every single criticism helped improve the paper, but the negative tone of the reviewers was sometimes hard to take.

Did you receive any guidance from your supervisors?

Both my supervisors strongly feel that as a first author I should be in charge of writing the first draft of the paper and involved in the whole process. Dr. Aubert made sure that I was the one to submit the paper—filling out the online forms and clicking the “send” but-ton. I relied on their expertise a lot [for things like] where to submit and how to write the paper. Even though I’ve read papers, when you go to write your own paper sometimes it’s hard because you spend so much time focusing closely on the project; it’s hard to step back and tell your story appropriately to your audience.

What did you learn about the process?

[Dr. Aubert] always says if you want to achieve something big, aim bigger. Also, when you’re building your paper, you should start with figures that represent the main experimental findings because they tell your story. Write around these figures. Draw the most important conclusion, then go back and introduce the work accordingly.

Is there anything you wish you had known beforehand?

Start writing earlier. The process can be longer than you origi-nally anticipate it to be. Writing once was not so bad, but what followed was tedious. There were revisions and waiting for [the reviewers] to get back to us. We were refining the details of the figures and rewriting until it was concise. And wording is always so important; you have to make sure everything is clear.

Trainees’ PostFor Students by StudentsA first-time lead author shares her thoughts on getting published

“There’s no great writing, only great rewriting,” said U.S. Su-preme Court Justice Louis Brandeis. Jessica Jordão, a PhD student training in the labs of brain scientist Dr. Isabelle Aubert and Dr. Kullervo Hynynen, director of imaging at Sunnybrook Research Institute, learned this lesson firsthand with the recent publication of her paper. After numerous revisions and back-and-forth sessions with reviewers, the paper—on which she is the first author—was accepted and published in May in PLoS ONE, an online journal of the California-based Public Library of Science. “For Jessica, this first paper is a great achievement,” says Aubert. “It represents close to three years of work from be-ginning to end. This publication represents her official authorship ‘birth date’—an important milestone in Jessica’s career.”

Between her research, coursework and planning a spring wed-ding, it has been a busy year for Jordão. Here, she tells Alisa Kim what she discovered about the process of getting a paper published, including what to expect next time. Jessica Jordão is a PhD student training in the labs of Drs. Isabelle

Aubert and Kullervo Hynynen

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Applause

Amy BakerCanadian Institutes of Health Research Canada Graduate Scholarship

The Canadian Institutes of Health Research awarded Amy Baker, a PhD student in the lab of brain sciences re-searcher Dr. Miles Johnston, a Canada Graduate Scholarship worth $105,000 over three years. Baker is study-ing a potential new therapy for the prevention of lymphedema. This condition is common among breast cancer survivors, in whom lymphatic system disruption can lead to fluid retention that results in infections, impaired limb function and sometimes death.

Melissa HillCanadian Breast Cancer Foundation Doctoral Fellowship

The Canadian Breast Cancer Foundation awarded Melissa Hill a doctoral fellowship worth $75,000 over two years. Hill, a student in the lab of imaging senior scientist Dr. Martin Yaffe, is researching ways to improve mammographic screening through contrast-enhanced breast tomosynthesis, a digital X-ray technique that produces three-dimensional images.

Dr. Jacob LevmanCanadian Breast Cancer Foundation Postdoctoral Fellowship

The Canadian Breast Cancer Foundation awarded Dr. Jacob Levman a postdoctoral fellowship worth $95,000 over two years to study early breast cancer detection by computer-aided diagnosis of magnetic resonance imaging. Levman is a postdoc in the lab of imaging senior scientist Dr. Anne Martel.

Dr. Mario MasellisCanadian Institutes of Health Research Clinician Scientist Award

Dr. Mario Masellis, an associate scientist in the discipline of clinical integrative biology, was awarded a Phase 1 Clinician Scientist award from CIHR. The award, worth $57,500 over one year, provides training support to highly qualified individuals who are recognized as having strong potential to become clinician scientists. Masellis will use the funds for his research on the drug rivastigmine to treat neurodegenerative disorders such as Parkinson’s disease and Lewy Body disease.

Dr. Bojana StefanovicCanadian Institutes of Health Research New Investigator Award

Dr. Bojana Stefanovic, an imaging scientist in the Brain Sciences Research Program, received a New Investi-gator award from CIHR. The aim of the award is to help new researchers demonstrate their independence in conducting health research through provision of a contribution to their salary. Stefanovic will receive $300,000 over five years for her research on the biophysics of functional magnetic resonance imaging.

Dr. Jill TinmouthCanadian Institutes of Health Research New Investigator Award

Dr. Jill Tinmouth, a scientist in clinical epidemiology, received a New Investigator award from CIHR. Tinmouth will use the award, worth $300,000 over five years, to investigate the transmission and progression of anal cancer in HIV-infected men, toward development of a screening program.

WHAT’S ON

Editor: Stephanie RobertsContributors: Dilys Chan, Alisa Kim, Jim Oldfield Photography: Doug Nicholson

Nexus is published by the office of communications, Sunnybrook Research Institute: www.sunnybrook.ca/research. We welcome your suggestions. Please send them to Jim Oldfield at jim.oldfield@sri.utoronto.ca.

June 9–August 4Summer student seminar seriesWednesdays, 1:30–2:30 p.m.SG 22

July 12Hospital for Sick Children Alternative Careers in Science Symposium1:00–5:00 p.m.MaRS Centre, 101 College Street

July 26MaRS Future of Medicine: Lessons Learned as an Entrepreneur12:00–1:30 p.m.MaRS Centre, 101 College Street

August 11Summer student research programPoster presentations2:00–4:30 p.m.McLaughlin auditorium EG 18a

August 22Labour of Love: Walk for Women and Babies9:00 a.m. Women’s College Hospital, 95 Grosvenor Streetwww.sunnybrooklove.ca

On June 11, Dr. Graham Wright (right) moderated Sunnybrook Research Institute’s third annual Canadian CTO Summit, a re-search day devoted to chronic total occlusions. Dr. Bradley Strauss (left) gave two talks and reported results from the first-in-man trial of collagenase, a promising new formulation that can loosen arterial blockages; Dr. Olivier Bertrand (centre-left) and Dr. José P.S. Henriques (centre-right) presented keynote lectures. For more on the event, visit www.sunnybrook.ca/research.