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Sudden Death and Sickle Cell Trait: How Knowing Your Genes Can Save Your Life
Dale Lloyd II, No. 39. (The Rice Football Webletter)
2006
After running 16 consecutive sprints of 100 yards each, he collapsed.He died the next day from acute exertional rhabdomyolysis (ER) associated with a genetic condition called sickle cell trait.
Learning Set 4 : Lesson 1 : Slide 1
Normal Blood Cells
Sickle Cell Trait Blood Cells
Sickle Cell Disease Blood Cells
Learning Set 4 : Lesson 1 : Slide 2
Blood Cells
• View video on sickle cell trait
• Interview with sickle cell patient: pain
Learning Set 4 : Lesson 1 : Slide 3
• View Video on sickle cell anemia
Sickle Cell Disease
Red Blood Cell
Oxygen molecule
Hemoglobin subunit
o o
Learning Set 4 : Lesson 1 : Slide 4
Hemoglobin
Red Blood Cell
oxygen molecule (O2)Hemoglobin
subunit
Learning Set 4 : Lesson 1 : Slide 5
Hemoglobin (transport protein)
• Charge– Positive and negative charged amino
acids attract each other– Amino acids with the same kind of charge
repel each other• Hydrophobicity
– Hydrophilic amino acids attract water– Hydrophobic amino acids repel water and
hydrophilic amino acids– Hydrophobic amino acids attract other
hydrophobic amino acids.• Cysteines
– Cysteines are a type of amino acid. When two Cysteines are next to each other they attract and form a strong bond. These strong bonds contribute to protein shape formation.
Red = positive charge (+)K, R, H
Yellow = negative charge (-)D, E
Green = hydrophobicA, V, L, I, P, M, F, W
Blue = hydrophilicG, S, T, N, Q, Y
White = cystine C
Learning Set 4 : Lesson 2 : Slide 12
“Rules” that amino acids follow
L T P E E K S L T P V E K S
DNA
order of amino acids
protein shape
cell function
Learning Set 4 : Lesson 2 : Slide 14
Effects of Sickle Cell Mutation
http://www.pbs.org/wgbh/evolution/library/01/2/l_012_02.html
Learning Set 4 : Lesson 4 : Slide 17Learning Set 4 : Lesson 4 : Slide 17
Frequency of Sickle Cell Causing Mutation vs. Frequency of Malaria Causing Microbe
Analyzing RNA Using Gel Electrophoresis
Learning Set 4 : Lesson 5 : Slide 18Learning Set 4 : Lesson 5 : Slide 18
Who has lactose intolerance in Jason’s family?
Learning Set 4 : Lesson 5 : Slide 19Learning Set 4 : Lesson 5 : Slide 19
DNA Sequence Analysis of Lactase Protein Gene
Learning Set 4 : Lesson 5 : Slide 20Learning Set 4 : Lesson 5 : Slide 20
Gel Electrophoresis: Lactase Protein Samples from Jason’s Family
Learning Set 4 : Lesson 5 : Slide 21Learning Set 4 : Lesson 5 : Slide 21
RNA Analysis of Lactase Protein Gene
Learning Set 4 : Lesson 5 : Slide 22Learning Set 4 : Lesson 5 : Slide 22