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Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 101: Black, non−Hispanic, 10.7 y/o at enrollment
TaxonLactobacillus_iners
Lactobacillus_jensenii
Lactobacillus_crispatus
Lactobacillus_gasseri
Lactobacillus_Other
Prevotella
Anaerococcus
Finegoldia
Peptoniphilus
Other_Bacteria
Jonquetella
Bifidobacterium
Clostridiales
Clostridiales_Incertae_Sedis_XI
Megasphaera
Anaerosphaera
Corynebacterium
Dialister
Fusobacterium
Porphyromonas
Atopobium
Segniliparus
Actinomycetales
Gallicola
Campylobacter
● ● ● ● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
● ● ●
4.54 4 4
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11 12 13 14Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 102: Caucasian, non−Hispanic, 10.8 y/o at enrollment
TaxonGardnerella_vaginalis
Lactobacillus_iners
Lactobacillus_gasseri
Gardnerella_Other
Prevotella
Lactobacillus_crispatus
Atopobium
Dialister
Lactobacillus_jensenii
Lactobacillus_Other
Finegoldia
Ureaplasma
Anaerococcus
Megasphaera
Peptoniphilus
Other_Bacteria
Jonquetella
Alloscardovia
Coriobacteriaceae
Olsenella
Anaerosphaera
Veillonellaceae
Corynebacterium
Moryella
Staphylococcus
● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
● ●
●
●● ●
●
●
●
●
76.5 6.5
4.5
6.1 5.8 5.8
7
5.3
6.5
5.3
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11 12Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 103: Black, non−Hispanic, 10.7 y/o at enrollment
TaxonLactobacillus_gasseri
Lactobacillus_crispatus
Lactobacillus_jensenii
Streptococcus_anginosis
Bifidobacterium
Anaerococcus
Prevotella
Lactobacillus_Other
Peptoniphilus
Other_Bacteria
Lactobacillus_iners
Finegoldia
Corynebacterium
Bacteroides
Porphyromonas
Clostridiales_Incertae_Sedis_XI
Faecalibacterium
Clostridiales
Actinomyces
Lachnospiracea_incertae_sedis
Anaerosphaera
Dialister
Murdochiella
Moryella
Mobiluncus
● ● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ● ● ●
●
● ● ●
●
6.5 6.5 6.5 6.55.8
5 5 55.5
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11 12Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 104: Caucasian, non−Hispanic, 10.5 y/o at enrollment
TaxonLactobacillus_crispatus
Streptococcus_agalactiae
Streptococcus_anginosis
Finegoldia
Lactobacillus_iners
Prevotella
Klebsiella
Alloscardovia
Corynebacterium
Lactobacillus_jensenii
Peptoniphilus
Anaerococcus
Other_Bacteria
Lactobacillus_Other
Dialister
Staphylococcus
Segniliparus
Streptococcus_Other
Anaerosphaera
Clostridiales
Lactobacillus_gigeriorum
Gardnerella_vaginalis
Actinomycetales
Varibaculum
Acidovorax
● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●●
●
●
●●
76.5
6.1
7
6.1
7 6.7
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11 12Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 105: Caucasian, Hispanic, 10.2 y/o at enrollment
TaxonLactobacillus_crispatus
Prevotella
Gardnerella_vaginalis
Lactobacillus_gasseri
Anaerococcus
Peptoniphilus
Gardnerella_Other
Dialister
Lachnospiraceae
Clostridiales_Incertae_Sedis_XI
Mobiluncus
Lactobacillus_Other
Streptococcus_agalactiae
Other_Bacteria
Anaerosphaera
Finegoldia
Clostridiales
Actinobaculum
Gallicola
TM7_genera_incertae_sedis
Corynebacterium
Clostridium_sensu_stricto
Varibaculum
Aerococcus
Porphyromonas
● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ●
● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ●
●● ●
7 76.5
6.1 6.1
4
5
6
7
8
1 2 3 4 5 6Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 106: Black, non−Hispanic, 12.3 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Lactobacillus_jensenii
Lactobacillus_Other
Finegoldia
Prevotella
Anaerococcus
Peptoniphilus
Other_Bacteria
Lactobacillus_gasseri
Lactobacillus_gigeriorum
Clostridiales
Dialister
Anaerosphaera
Clostridiales_Incertae_Sedis_XI
Porphyromonas
Peptostreptococcus
Gardnerella_vaginalis
Lactobacillus_coleohominis
Staphylococcus
Bifidobacterium
Bacteroides
Corynebacterium
Segniliparus
Clostridium_XI
● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ●●
● ●●
●
4.5 4.5 4.74 4
4.44
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 107: Black, non−Hispanic, 12.4 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Corynebacterium
Gardnerella_vaginalis
Prevotella
Anaerococcus
Other_Bacteria
Lachnospiraceae
Lactobacillus_Other
Peptoniphilus
Finegoldia
Dialister
Lactobacillus_jensenii
Gardnerella_Other
Lactobacillus_gasseri
Megasphaera
Clostridiales
Actinomycetales
Atopobium
TM7_genera_incertae_sedis
Anaerosphaera
Clostridiales_Incertae_Sedis_XI
Porphyromonas
Veillonellaceae
Helcococcus
● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ● ●
●●
●●
● ● ●
4.5 4.5 4.55 4.7
44.4
4 4 44
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 108: Black, non−Hispanic, 11.5 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_gasseri
Lactobacillus_iners
Lactobacillus_Other
Gardnerella_vaginalis
Lactobacillus_jensenii
Other_Bacteria
Finegoldia
Staphylococcus
Acinetobacter
Acidovorax
Prevotella
Anaerococcus
Gardnerella_Other
Dialister
Cloacibacterium
Peptoniphilus
Corynebacterium
Lactobacillus_gigeriorum
Streptococcus_anginosis
Aerococcus
Actinomycetales
Clostridiales
Bifidobacterium
Segniliparus
● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
●
●
●● ●
●
6.5
4.55
4.54
4.4 4.44
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 109: Black, non−Hispanic, 10.6 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Gardnerella_vaginalis
Lactobacillus_Other
Corynebacterium
Megasphaera
Lachnospiraceae
Sneathia
Prevotella
Other_Bacteria
Atopobium
Gardnerella_Other
TM7_genera_incertae_sedis
Anaerococcus
Finegoldia
Dialister
Peptoniphilus
Ureaplasma
Staphylococcus
Actinomycetales
Veillonellaceae
Facklamia
Clostridiales
Jonquetella
Clostridiales_Incertae_Sedis_XI
● ● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
●
●
●●
●●
●
●
6.57
5
7.5
4.44
4.44
4.54
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10 11Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 110: Black, non−Hispanic, 10.1 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Finegoldia
Prevotella
Peptoniphilus
Dialister
Lactobacillus_gasseri
Lactobacillus_Other
Streptococcus_anginosis
Other_Bacteria
Staphylococcus
Corynebacterium
Fusobacterium
Lactobacillus_jensenii
Streptococcus_Other
Clostridium_sensu_stricto
Actinobaculum
Segniliparus
Actinomycetales
Veillonellaceae
Varibaculum
Anaerococcus
Facklamia
Clostridiales
Atopobium
● ●Menarche
Menarche status
●●
Pre
Post
● ●
● ●Genital
Breast
1 2Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 111: Black, non−Hispanic, 10.4 y/o at enrollment
TaxonLactobacillus_gasseri
Prevotella
Lactobacillus_iners
Streptococcus_anginosis
Lactobacillus_jensenii
Lactobacillus_Other
Lactobacillus_crispatus
Anaerococcus
Peptoniphilus
Gardnerella_vaginalis
Finegoldia
Mobiluncus
Streptococcus_agalactiae
Other_Bacteria
Varibaculum
Dialister
Anaerosphaera
Clostridiales_Incertae_Sedis_XI
Bifidobacterium
Lachnospiracea_incertae_sedis
Streptococcus_Other
Propionimicrobium
Corynebacterium
Gardnerella_Other
Clostridiales
● ● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ●
●
● ●●
●5 5
5.8
4.4 4.4 4.7 5
4
5
6
7
8
1 2 3 4 5 6 7 8 9 10Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 112: Black, non−Hispanic, 10.1 y/o at enrollment
TaxonLactobacillus_iners
Lactobacillus_gasseri
Atopobium
Gardnerella_vaginalis
Lactobacillus_jensenii
Lactobacillus_Other
Prevotella
Bradyrhizobiaceae
Fusobacterium
Corynebacterium
Other_Bacteria
Finegoldia
Gardnerella_Other
Bacteroides
Streptococcus_agalactiae
Anaerococcus
Peptoniphilus
Ureaplasma
Parvimonas
Staphylococcus
Helcococcus
Dialister
Porphyromonas
Acidovorax
Dyella
● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ● ●
● ●
●
● ●
4.5 4.5 4.54 4.1
6.5
4 44
5
6
7
8
1 2 3 4 5 6 7 8 9Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 113: Black, non−Hispanic, 11.6 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Lactobacillus_jensenii
Lactobacillus_Other
Clostridium_sensu_stricto
Other_Bacteria
Prevotella
Finegoldia
Peptoniphilus
Clostridiales
Streptococcus_Other
Anaerococcus
Anaerosphaera
Clostridiales_Incertae_Sedis_XI
Clostridium_XI
Lactobacillus_coleohominis
Staphylococcus
Anaerovorax
Lactobacillus_gasseri
Bifidobacterium
Faecalibacterium
Dialister
Ruminococcaceae
Megasphaera
Gemella
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ● ●
● ●●
4.5 4.5 4.54 4
4.44
5
6
7
8
1 2 3 4 5 6Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 114: Black, non−Hispanic, 11 y/o at enrollment
TaxonLactobacillus_iners
Lactobacillus_gasseri
Lactobacillus_Other
Lactobacillus_crispatus
Gardnerella_vaginalis
Prevotella
Finegoldia
Lactobacillus_jensenii
Other_Bacteria
Peptoniphilus
Jonquetella
Sneathia
Atopobium
Fusobacterium
Peptostreptococcus
Dialister
Campylobacter
Veillonella
Gardnerella_Other
Staphylococcus
Corynebacterium
Anaerococcus
Ureaplasma
Clostridium_sensu_stricto
Streptococcus_anginosis
● ● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ● ● ●
● ● ● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●●
●
●
4.44
4.54
4
5
6
7
8
1 2 3 4 5 6 7 8 9Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 115: Caucasian, non−Hispanic, 11 y/o at enrollment
TaxonLactobacillus_iners
Gardnerella_vaginalis
Lactobacillus_gasseri
Lactobacillus_crispatus
Gardnerella_Other
Lactobacillus_Other
Prevotella
Lactobacillus_jensenii
Sneathia
Anaerococcus
Megasphaera
Atopobium
Peptoniphilus
Finegoldia
Other_Bacteria
Coriobacteriaceae
Clostridiales_Incertae_Sedis_XI
Dialister
Clostridiales
Porphyromonas
Ruminococcaceae
Corynebacterium
Veillonellaceae
Staphylococcus
Anaerosphaera
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
1 2 3 4 5 6Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 116: Black, non−Hispanic, 11.2 y/o at enrollment
TaxonLactobacillus_iners
Prevotella
Peptoniphilus
Corynebacterium
Anaerococcus
Gardnerella_vaginalis
Anaerosphaera
Campylobacter
Other_Bacteria
Arcanobacterium
Lactobacillus_Other
Streptococcus_anginosis
Clostridiales
Clostridiales_Incertae_Sedis_XI
Finegoldia
Fastidiosipila
Porphyromonas
Lactobacillus_crispatus
Gallicola
Dialister
Facklamia
Gardnerella_Other
Mobiluncus
Ureaplasma
Helcococcus
● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ●
● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●7
4
5
6
7
8
1 2 3Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 118: Caucasian, non−Hispanic, 11.3 y/o at enrollment
TaxonPeptoniphilus
Prevotella
Anaerosphaera
Clostridiales
Anaerococcus
Porphyromonas
Clostridiales_Incertae_Sedis_XI
Ruminococcaceae
Moryella
Sneathia
Campylobacter
Porphyromonadaceae
Dialister
Other_Bacteria
Parvimonas
Gardnerella_vaginalis
Arcanobacterium
Finegoldia
Gardnerella_Other
Gordonibacter
Mycoplasma
Fastidiosipila
Mobiluncus
Peptococcus
Atopobium
●Menarche
Menarche status
●●
Pre
Post
●
●Genital
Breast
1Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 120: Black, non−Hispanic, 12 y/o at enrollment
TaxonLactobacillus_iners
Gardnerella_vaginalis
Prevotella
Lactobacillus_crispatus
Anaerococcus
Peptoniphilus
Finegoldia
Dialister
Megasphaera
Lactobacillus_jensenii
Sneathia
Lachnospiraceae
Other_Bacteria
Gardnerella_Other
Lactobacillus_Other
Atopobium
Clostridiales
Anaerosphaera
Mycoplasma
Mobiluncus
Fusobacterium
Clostridiales_Incertae_Sedis_XI
Porphyromonadaceae
Campylobacter
Veillonellaceae
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
● ●
7
5
6.1 6.1
4
5
6
7
8
1 2 3 4 5 6Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 121: Black, non−Hispanic, 10.1 y/o at enrollment
TaxonLactobacillus_crispatus
Gardnerella_vaginalis
Lactobacillus_iners
Prevotella
Atopobium
Anaerococcus
Lactobacillus_Other
Peptoniphilus
Finegoldia
Veillonella
Lactobacillus_jensenii
Gardnerella_Other
Anaerosphaera
Clostridiales
Dialister
Sneathia
Other_Bacteria
Corynebacterium
Gemella
Coriobacteriaceae
Porphyromonas
Ureaplasma
Lactobacillus_gasseri
Clostridiales_Incertae_Sedis_XI
Ruminococcaceae
● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ●
●
●●
6.1 6.16.8
5 5.2
4
5
6
7
8
1 2 3 4 5 6 7 8Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 123: Black, non−Hispanic, 10.1 y/o at enrollment
TaxonLactobacillus_jensenii
Streptococcus_agalactiae
Streptococcus_anginosis
Lactobacillus_gasseri
Anaerococcus
Lactobacillus_crispatus
Corynebacterium
Lactobacillus_iners
Prevotella
Gardnerella_vaginalis
Peptoniphilus
Finegoldia
Lactobacillus_Other
Bifidobacterium
Other_Bacteria
Clostridiales
Dialister
Streptococcus_Other
Staphylococcus
Anaerosphaera
Propionimicrobium
Varibaculum
Actinomycetales
Facklamia
Clostridiales_Incertae_Sedis_XI
● ● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ●
● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
7
4.14
5
6
7
8
1 2 3 4 5 6 7 8Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 124: Black, non−Hispanic, 10.1 y/o at enrollment
TaxonLactobacillus_crispatus
Bifidobacterium
Streptococcus_anginosis
Gardnerella_vaginalis
Lactobacillus_gasseri
Other_Bacteria
Lactobacillus_jensenii
Finegoldia
Corynebacterium
Gemella
Aerococcus
Peptoniphilus
Lactobacillus_Other
Prevotella
Dyella
Dialister
Anaerococcus
Actinomyces
Lactobacillus_gigeriorum
Acidovorax
Gardnerella_Other
Staphylococcus
Escherichia_Shigella
Atopobium
Streptococcus_agalactiae
● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ●
● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●● ● ●4
4.4 4.5 4.5
4
5
6
7
8
1 2 3 4 5 6 7Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 125: Caucasian, non−Hispanic, 10.9 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Lactobacillus_jensenii
Finegoldia
Lactobacillus_Other
Prevotella
Anaerococcus
Other_Bacteria
Peptoniphilus
Corynebacterium
Dialister
Lactobacillus_gigeriorum
Clostridium_sensu_stricto
Clostridiales
Lactobacillus_coleohominis
Anaerosphaera
Lactobacillus_gasseri
Segniliparus
Megasphaera
Atopobium
Actinomycetales
Gardnerella_vaginalis
Fusobacterium
Clostridiales_Incertae_Sedis_XI
Porphyromonas
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
1 2 3 4 5 6Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 126: Caucasian, non−Hispanic, 10.6 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Lactobacillus_jensenii
Gardnerella_vaginalis
Corynebacterium
Lactobacillus_Other
Anaerococcus
Other_Bacteria
Finegoldia
Peptoniphilus
Clostridium_sensu_stricto
Staphylococcus
Clostridiales
Gardnerella_Other
Anaerosphaera
Lactobacillus_coleohominis
Lactobacillus_gasseri
Prevotella
Actinomycetales
Clostridiales_Incertae_Sedis_XI
Porphyromonas
Blautia
Lactobacillus_gigeriorum
Bifidobacterium
Acidovorax
● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
1 2 3 4 5 6 7 8Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 127: Native American, non−Hispanic, 12.1 y/o at enrollment
TaxonLactobacillus_iners
Lactobacillus_gasseri
Gardnerella_vaginalis
Prevotella
Atopobium
Other_Bacteria
Lactobacillus_Other
Gardnerella_Other
TM7_genera_incertae_sedis
Sneathia
Dialister
Megasphaera
Anaerosphaera
Anaerococcus
Clostridiales
Jonquetella
Paraprevotella
Ruminococcaceae
Peptoniphilus
Murdochiella
Porphyromonas
Fusobacterium
Veillonellaceae
Bifidobacterium
Lachnospiraceae
● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ●
● ● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●4
4
5
6
7
8
1 2 3 4 5 6 7Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 128: Native American, non−Hispanic, 11 y/o at enrollment
TaxonLactobacillus_iners
Lactobacillus_crispatus
Gardnerella_vaginalis
Lactobacillus_gasseri
Prevotella
Lactobacillus_Other
Sneathia
Other_Bacteria
Atopobium
Dialister
TM7_genera_incertae_sedis
Megasphaera
Gardnerella_Other
Ruminococcaceae
Finegoldia
Clostridium_sensu_stricto
Lachnospiraceae
Veillonellaceae
Coriobacteriaceae
Anaerococcus
Peptoniphilus
Fusobacterium
Corynebacterium
Acidovorax
Clostridiales
● ● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●● ●
●
44.4 4.4
5.5
4
5
6
7
8
1 2 3 4 5 6 7Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 129: Caucasian, non−Hispanic, 10.6 y/o at enrollment
TaxonGardnerella_vaginalis
Lactobacillus_crispatus
Lactobacillus_iners
Prevotella
Peptoniphilus
Anaerococcus
Clostridiales
Clostridiales_Incertae_Sedis_XI
Anaerosphaera
Gardnerella_Other
Porphyromonas
Jonquetella
Dialister
Lactobacillus_Other
Other_Bacteria
Pyramidobacter
Moryella
Paraprevotella
Porphyromonadaceae
Campylobacter
Lactobacillus_gasseri
Finegoldia
Segniliparus
Murdochiella
Peptococcus
●Menarche
Menarche status
●●
Pre
Post
●
●Genital
Breast
1Visit
Tanner stage
●●●●●
1
2
3
4
5
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 132: Black, non−Hispanic, 10.2 y/o at enrollment
TaxonPrevotella
Lactobacillus_iners
Anaerococcus
Lactobacillus_crispatus
Peptoniphilus
Lactobacillus_gasseri
Clostridiales_Incertae_Sedis_XI
Anaerosphaera
Porphyromonas
Clostridiales
Jonquetella
Other_Bacteria
Mobiluncus
Campylobacter
Moryella
Actinomyces
Peptococcus
Corynebacterium
Saccharofermentans
Anaerovorax
Dialister
Fusobacterium
Streptococcus_anginosis
Finegoldia
Segniliparus
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ● ●
● ● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
● ● ●
●
●
7 7 7
5.86.5
4
5
6
7
8
1 2 3 4 5 6Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 133: Black, non−Hispanic, 11.6 y/o at enrollment
TaxonLactobacillus_crispatus
Lactobacillus_iners
Anaerococcus
Prevotella
Corynebacterium
Mobiluncus
Peptoniphilus
Lactobacillus_Other
Other_Bacteria
Actinomyces
Dialister
Jonquetella
Clostridiales
Anaerosphaera
Lactobacillus_jensenii
Finegoldia
Fusobacterium
Actinomycetales
Bifidobacterium
Moryella
Clostridiales_Incertae_Sedis_XI
Porphyromonas
Streptococcus_anginosis
Campylobacter
Ruminococcaceae
● ● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ●
● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●●
●
6.5
4.44
4.44
5
6
7
8
1 2 3 4 5 6Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 134: Black, non−Hispanic, 10.8 y/o at enrollment
TaxonAnaerococcus
Alloscardovia
Prevotella
Lactobacillus_iners
Peptoniphilus
Finegoldia
Corynebacterium
Clostridiales_Incertae_Sedis_XI
Other_Bacteria
Anaerosphaera
Gallicola
Lactobacillus_gasseri
Porphyromonas
Clostridiales
Actinomyces
Streptococcus_anginosis
Facklamia
Campylobacter
Dialister
Lactobacillus_Other
Fastidiosipila
Actinomycetales
Actinobaculum
Peptococcus
Segniliparus
● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ●
● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●4.7
4
5
6
7
8
1 2 3 4 5Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
Mother Vagina
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00
Pro
port
ion
Subject 135: Black, non−Hispanic, 11.1 y/o at enrollment
TaxonGardnerella_vaginalis
Prevotella
Lactobacillus_iners
Gardnerella_Other
Mobiluncus
Peptoniphilus
Anaerococcus
Lactobacillus_gasseri
Dialister
Porphyromonadaceae
Other_Bacteria
Clostridiales
Clostridiales_Incertae_Sedis_XI
Porphyromonas
Anaerosphaera
Finegoldia
Campylobacter
Murdochiella
Varibaculum
Lactobacillus_Other
Corynebacterium
Aerococcus
Peptococcus
Atopobium
Gallicola
● ● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ● ●
● ● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
5.3
6.5
4
5
6
7
8
1 2 3 4 5Visit
Vag
inal
pH
Girl Vagina
Girl Vulva
0.00
0.25
0.50
0.75
1.00
0.00
0.25
0.50
0.75
1.00Pro
port
ion
Subject 136: Black, non−Hispanic, 10.6 y/o at enrollment
TaxonLactobacillus_gasseri
Prevotella
Lactobacillus_crispatus
Escherichia_Shigella
Streptococcus_anginosis
Anaerococcus
Peptoniphilus
Mobiluncus
Other_Bacteria
Clostridiales
Moryella
Porphyromonas
Dialister
Anaerosphaera
Bifidobacterium
Clostridiales_Incertae_Sedis_XI
Lactobacillus_Other
Finegoldia
Streptococcus_Other
Jonquetella
Actinomyces
Campylobacter
Murdochiella
Lachnospiracea_incertae_sedis
Faecalibacterium
● ● ● ●Menarche
Menarche status
●●
Pre
Post
● ● ● ●
● ● ● ●Genital
Breast
Tanner stage
●●●●●
1
2
3
4
5
●
●
●
7
5.85
4
5
6
7
8
1 2 3 4Visit
Vag
inal
pH
