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Structure and dynamics of brain networks in common epilepsies
Current research focus on a single broad and important question in epilepsy:
How do epileptic seizures emerge suddenly from the normal activity of brain networks?
Emphasis on common epilepsies and multidisciplinary approach (imaging, electrophysiology, computational modelling)
We seek to answer this question using data obtained directly from people with epilepsy
This question has three main elements:
Which brain networks are implicated in the mechanisms of epileptic seizures?How do these networks differ between people with epilepsy and without?Why are these abnormal networks able to suddenly generate seizures?
Here illustrated by a study of primary generalised epilepsy ………
39 IGE patients40 1st-degree relatives42 normal controls
EEG signal filtered into 5 bands: delta, theta, alpha, beta, gamma
Network of connections between EEG electrodes derived for each frequency band
METHOD
NETWORK TOPOLOGY
DYNAMICMODEL
28 IGE patients55 controlsDiffusion tensor imaging (DTI)Analysed using TBSS
People with IGE have abnormal structural and functional brain networks
These network abnormalities are heritable
Dynamic modelling reveals that these abnormal networks are inherently unstable and spontaneously generate seizure-like activity