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STROKE - IMAGING
Dr RAJASEKHAR REDDY
2nd Yr P.G. RADIODIAGNOSIS
KIMS,Narkatpalli.
STROKE
• Describes a clinical event that consists of sudden onset of neurological symptoms
Types
• Infarction - occlusion of cerebral arteries and veins(85%)
• Hemorrhage – intraparenchymal , subarachnoid
• Infarction without occlusion of cerebral arteries or veins may also occur-severe sustained hypotension,toxic ,anoxic insult
Imaging manifestations of ischemia -infarction
These vary with time
• Acute (upto-24hrs)
• Subacute –early,late ( 1-7 days. )
• Chronic (after 3 weeks )
CT
Hyperacute (<12hrs)
• 50 to 60 % normal
• Hyperdense middle cerebral artery
• Obscuration of lentiform nuclei
• Insular- ribbon sign
Acute(12 to 24hrs)
• Low density basal ganglia
• Loss of grey –white interface
• Sulcal effacement (gyral swelling)
Hyperdense MCA low density basal ganglia
CT axial plain
Subacute early (1 to 3 days)
• Wedge shaped low density area involving both grey and white matter
• Hemorrhagic transformation may occur
• Increasing mass effect
brain herniation
ventricular trapping(raised Intra Cranial Tension)
• If extensive can result in life threatening-malignant brain edema in cases of Internal Carotid Artery Occlusion,ICA dissection.
CT axial plain
SubAcute infarct
Subacute late (4 to 7 days)
• Gyral enhancement
• Mass effect,edema persist
Chronic
• Encephalomalacic changes,volume loss
• Calcification rare
MRI
• Diffusion weighted sequence is sensitive in acute infarcts
Hyperacute :- Immediate
• Absence of normal flow void
• <12 hrs- gyral edema, sulcal effacement , loss of grey white interface
• In hyperacute – diffusion restriction is seen with low ADC values (decrease to 30 to 40% below normal)
12 to 24hrs : -
• Hyperintensity on T2
• Meningeal enhancement, mass effect
• Intravascular contrast enhancement.
T1W E+ axial
coronal
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DIFFUSION WEIGHTED IMAGING
PRINCIPLE
IN Acute stroke – Due to alteration of
homeostasis results in excess intracellular
water accumulation - cytotoxic edema
- with an overall decreased rate of water
molecular diffusion within the affected tissue
Showing diffusion restriction which appers
bright.
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Late subacute
• Gs effect resolves
• T2 fogging
• Hemorrhagic changes
Chronic
• Enc
• Hemorrhagic residua
• Wallerian degener
T2W axial TIW E+axial
Subacute infarct on MRI
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C.T ANGIOGRAPHY
• C.T Angiography -widely available technique for assesement of both the intracranial and extracranial circulation.
• C.T Angiographic demonstration of a significant thrombus can guide appropriate therapy in the form of intra arterial or mechanical thrombolysis.
• Furthermore ,identification of the carotid disease and visualisation of the aortic arch can provide clues to the cause of the ishemic event and guidance for the I.R
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• Similar findings can be obtained by
MR Angiography.
• Like CT Angio MR Angio is useful for detection of intravascular occlusion due to thrombus and for evaluating the carotid bifurcation in patients with acute stroke.
• Time of Flight MR and contrast enhanced MR angio commonly used to evaluate intra cranial and extracranial circulation
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C.T PERFUSION IMAGING • Used in the assesement of ischemic penumbra
• This is done by measuring,
• -cerebral blood volume
• -cerebral blood flow
• Mean Transit Time - time difference between
arterial and venous (inflow and outflow )
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ARTERIAL
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VENOUS
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• The evaluation of the Brain perfusion is based on the central volume principle which is
• Cerebral Blood Flow= Cerebral Blood Volume /Mean Transition Time.
• Both the arterial and venous Region of Interest are optimally chosen in large vessels that course in a direction nearly perpendicular to the plane of C.T acquisition .
• Arterial ROI Is typically either of two A.C.A or unaffected M.C.A , Venous ROI is placed over the superior sagittal sinus , transverse sinus .
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• Comparision of DWI and PWI
• - The lesion appears smaller on DWI Than on
the Perfusion Weighted Images.This is typically
observed in large vessel strokes.
• -The lesion appears same size on DWI and PWI
when the tissue is irreversibly infarcted and
there is no penumbra.
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• The lesion appears larger on DWI than on PW
Images or the lesion seen only on DW Images
but not on Perfusion Weighted images.
• These findings are usually associated with
early reperfusion of ischemic tissue.
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TAKE HOME MESSAGE
• In case of suspected infarct C.T is the modality of choice to rule out Haemorrhage & to find early signs of infarction.
• However it should be followed by DWI of brain to early visualisation of acute infarct (about 30 min )
• Further advanced imaging modalities like CT/MR Angiography for localisation of Vascular Pathology.
• Perfusion study is done to look for Penumbra (salvagable brain parenchyma ) & planning of interventions.
THANK YOU
• THANK YOU