Bidirectional

STRATAFIX™ Knotless Tissue Control Devices The most versatile portfolio that competitors can’t match

Stratafix™

FeaturesSTRATAFIX Knotless Tissue Control Devices

V-Loc™

Wound Closure Devices

Quill™ Knotless Tissue Closure Devices

Superior tissue-holding strength1* ü No No

Antibacterial properties ü 2,3No 4,5 No 6-9

Extended wound-holding strength ü 10,11No 4,5 ü 7

Appropriate for use in fascia* ü 1, 12-16No 4,5 No 6-9

Superior needle performance17,18 ü No No

Multiple anchor designs/configurations ü No No

*Refers to STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device only.

STRATAFIX™ Symmetric Knotless Tissue Control Device

Unidirectional

STRATAFIX™ Spiral Knotless Tissue Control Devices

Unidirectional

STRATAFIX Symmetric PDS Plus Device

V-Loc™ 180 Wound Closure Device

Mea

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Tissue-holding strength1

78.38

90.06

Antibacterial properties2,3

V-Loc™ Device

STRATAFIX Spiral Device

The petri dish image is for illustrative purposes only, zone of inhibition testing results can vary.

The third-party trademarks used herein are trademarks of their respective owners.

Stratafix™© 2018 Ethicon US, LLC. 035855-180607

Features STRATAFIX Knotless Tissue Control Devices V-Loc™ Wound Closure Devices Quill™ Knotless Tissue Closure Devices

Superior tissue- holding strength

STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device demonstrated superior tissue-holding strength in fascia when compared to Looped PDS® Plus Antibacterial (polydioxanone) Suture, and Coated VICRYL® (polyglactin 910) Suture (interrupted technique)1

Inferior tissue-holding strength when compared to STRATAFIX Symmetric PDS Plus Device in subcutaneous tissue 1

Inferior tissue-holding strength compared to STRATAFIX Symmetric PDS Plus Device in subcutaneous tissue 1,15

Antibacterial properties

STRATAFIX Symmetric PDS Plus Device, STRATAFIX Spiral MONOCRYL Plus Device, and STRATAFIX Spiral PDS Plus Device have been shown in vitro to inhibit bacterial colonization of the suture for 7 days or more2,3

V-Loc™ portfolio does not offer antibacterial products4,5

Quill™ portfolio does not offer antibacterial products 6-9

Extended tensile strength

STRATAFIX™ Spiral PDO Knotless Tissue Control Device, STRATAFIX Spiral PDS Plus Device, and STRATAFIX Symmetric PDS Plus Device can be used in closures that require up to 6 weeks of tissue approximation10,11,19

The V-Loc™ 180 Absorbable Wound Cosure Device is not for use where prolonged (beyond 3 weeks) approximation of tissues under stress is required 4

Quill™ PDO can be used in closures that require up to 6 weeks of tissue approximation7

Appropriate for use in fascia

STRATAFIX Symmetric PDS Plus Device is designed for use in high-tension areas, such as fascia1,12-16

Warning in label states the safety and effectiveness of V-Loc™ has not been established for use in fascial closures4,5

Warning in label states the safety and effectiveness of Quill™ has not been established for use in fascial closures 6-9

Superior needle performance17,18

In benchtop testing versus V-Loc™ and Quill™, Ethicon needles displayed:• Greater strength* regardless of angle• Better penetration from the first to the last pass

Compared to STRATAFIX™ needles, Medtronic V-Loc™ needles showed less strength,* required greater pene-tration force, and showed more variability in penetration force required

Compared to STRATAFIX™ needles, Quill™ needles showed less strength,* required greater penetration force, and showed more variability in penetration force required

Multiple anchor designs/configurations

• Available in spiral designs (unidirectional and bidirectional) and symmetric designs

• Available in “cut” and “punched” technologies

• Available in spiral design only• Only available in “cut” technologies

• Available in spiral design only• Only available in “cut” technologies

With STRATAFIX™ Knotless Tissue Control Devices, Ethicon continues a century-long tradition of advancements in Wound Closure

Only Ethicon offers tissue control devices, with Plus Antibacterial Technology, that provide appropriate strength for closing high-tension areas, such as fascia 1,12-16†

*Overall Strength, measured as Bend Moment, is a product of Surgical Yield, Ultimate Moment, Reshape, and Stiffness characteristics. †Refers to STRATAFIX Symmetric PDS Plus Device only.

References: 1. 100326296: Time Zero Tissue Holding - Competitive Claims Comparisons for STRATAFIX Knotless Tissue Control Devices vs Various Products. 2015. Ethicon, Inc. 2. Ming X, Rothenburger S, Yang D. In vitro antibacterial efficacy of Monocryl Plus Antibacterial Suture (poligelcaprone 25 with triclosan). Surg Infect (Larchmt). 2007;8(2):201-207. 3. Ming X, Rothenburger S, Nichols MM. In vivo and in vitro antibacterial efficacy of PDS Plus (polidioxanone with triclosan) suture. Surg Infect (Larchmt). 2008;9(4):451-457. 4. V-Loc™180 Absorbable Wound Closure Device Instructions for Use. Norwalk, CT. Medtronic. 5. V-Loc™ 90 Absorbable Wound Closure Device Instructions for Use. Norwalk, CT. Medtronic. 6. Quill Self-Retaining System (SRS) Comprised of Monoderm (PGA-PCL) Synthetic Absorbable Surgical Suture Material Instructions for Use. Reading, PA: Surgical Specialties Corporation. 7. Quill Self-Retaining System (SRS) Comprised of Dyed PDO (Polydioxanone) Synthetic Absorbable Surgical Suture Material Instructions for Use. Reading, PA: Surgical Specialties Corporation. 8. Quill Self-Retaining System (SRS) Comprised of Polypropylene Non-absorbable Surgical Suture Material Instructions for Use. Reading, PA: Surgical Specialties Corporation. 9. Quill Self-Retaining System (SRS) Comprised of Nylon Non-absorbable Surgical Suture Material Instructions for Use. Reading, PA: Surgical Specialties Corporation. 10. STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device Instructions for Use. Ethicon, Inc. 11. STRATAFIX™ Spiral PDS™ Plus Knotless Tissue Control Device Instructions for Use. Ethicon, Inc. 12. Ethicon study AST-2011-0210. Study to evaluate the tissue holding performance at time zero of DOLFIN PDS PLUS barbed suture sizes 1 and 2-0 vs dyed PDS II Plus suture sizes 1 and 2-0 in a continuous stitch pattern—Project DOLFIN 11822, version 1. Approved on July 15, 2011. Ethicon, Inc. 13. Ethicon study AST-2011-0341. Performance testing of DOLFIN PDS PLUS size 3-0 suture—tissue holding 10 cm incision. Approved on August 22, 2011. Ethicon, Inc. 14. Ethicon study PSE 09-0204, project number 11822. Exploratory histological and biomechanical evaluation of DOLFIN following closure of the ventral abdominal wall in a porcine model at 7±1 days. Approved on July 7, 2010. Ethicon, Inc. 15. Ethicon study PSE 10-0012, project number 11822. Model development: histological and biomechanical evaluation of 3-0 DOLFIN barbed suture prototypes, 3-0 Quill suture, and 3-0 V-loc suture at 7±1 days following closure of the ventral abdominal wall in a rabbit model. Approved on August 8, 2011. Ethicon, Inc. 16. Performance Testing of STRATAFIX SYMMETRIC PDS PLUS Size 0 & 1 Devices – Initiation Strength in Porcine Tissue. AST-2013-0603. Ethicon, Inc. 17. Technical Memo CT12-009. December 12, 2012. Ethicon, Inc. 18. Technical Memo CT09-022. January 20, 2010. Ethicon, Inc. 19. STRATAFIX™ Spiral PDO Knotless Tissue Control Device Instructions for Use. Ethicon, Inc.

For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.