srdr.ahrq.gov€¦ · XLS file · Web view · 2014-10-29Project ID (SRDR) 135 Creator Gaelen Adam Organization Brown University Title The Relationships of Vitamin D and Calcium

135

Creator Gaelen Adam

Organization Brown University

TitleDescriptionContributorsMethodologyNotesFunding AgencyExtraction Form

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Study ID:EF ID Creator Create Date PMID6304:194 admin Aug 18, 2013 Sep 5, 2014 185059676305:194 admin Aug 18, 2013 Sep 5, 2014 110758746306:194 admin Aug 18, 2013 Sep 5, 2014 126632776307:194 admin Aug 18, 2013 Sep 5, 2014 78928826308:194 admin Aug 18, 2013 Sep 5, 2014 162804276309:194 admin Aug 18, 2013 Sep 5, 2014 182086366311:194 admin Aug 18, 2013 Sep 5, 2014 13303606312:194 admin Aug 18, 2013 Sep 5, 2014 86211986313:194 admin Aug 18, 2013 Sep 5, 2014 97435116314:194 admin Aug 18, 2013 Sep 5, 2014 157673346315:194 admin Aug 18, 2013 Sep 5, 2014 161034506316:194 admin Aug 18, 2013 Sep 5, 2014 179650376317:194 admin Aug 18, 2013 Sep 5, 2014 186895596318:194 admin Aug 18, 2013 Sep 5, 2014 175359856319:194 admin Aug 18, 2013 Sep 5, 2014 181983946320:194 admin Aug 18, 2013 Sep 5, 2014 172438666321:194 admin Aug 18, 2013 Sep 5, 2014 188427716322:194 admin Aug 18, 2013 Sep 5, 2014 83334126323:194 admin Aug 18, 2013 Sep 5, 2014 99219606324:194 admin Aug 18, 2013 Sep 5, 2014 3298936325:194 admin Aug 18, 2013 Sep 5, 2014 76128036326:194 admin Aug 18, 2013 Sep 5, 2014 187553196327:194 admin Aug 18, 2013 Sep 5, 2014 167979036328:194 admin Aug 18, 2013 Sep 5, 2014 176564206329:194 admin Aug 18, 2013 Sep 5, 2014 175025306330:194 admin Aug 18, 2013 Sep 5, 2014 115666566331:194 admin Aug 18, 2013 Sep 5, 2014 19001601

Project ID (SRDR)

The Relationships of Vitamin D and Calcium Background: Since the 1997 Dietary Reference Mei Chung, MPH Ethan M Balk, MD, MPH Michael Search terms that were used to identify outcomes For access to the full report available on the The Office of Dietary Supplements/National Vitamin D and Calcium RelationshipsKey Questions

for this Quality of Interventional StudiesQuality of Cohort or Nested Case-control What is the effect of exposures on functional or What is the effect of exposures on indicators of What is the effect of indicators of exposure or What is the effect of exposures on indicators of What is the effect of indicators of exposure or What is the effect of intermediate indicators of

Last Updated

6333:194 admin Aug 18, 2013 Sep 5, 2014 162804476334:194 admin Aug 18, 2013 Sep 5, 2014 152130386335:194 admin Aug 18, 2013 Sep 5, 2014 82200926336:194 admin Aug 18, 2013 Sep 5, 2014 86824536337:194 admin Aug 18, 2013 Sep 5, 2014 88906616338:194 admin Aug 18, 2013 Sep 5, 2014 171895526339:194 admin Aug 18, 2013 Sep 5, 2014 162782626340:194 admin Aug 18, 2013 Sep 5, 2014 80781156341:194 admin Aug 18, 2013 Sep 5, 2014 153424526342:194 admin Aug 18, 2013 Sep 5, 2014 156684856343:194 admin Aug 18, 2013 Nov 6, 2013 19376626344:194 admin Aug 18, 2013 Sep 5, 2014 173720316345:194 admin Aug 18, 2013 Sep 5, 2014 188386236346:194 admin Aug 18, 2013 Sep 5, 2014 179715266347:194 admin Aug 18, 2013 Sep 5, 2014 183814726348:194 admin Aug 18, 2013 Sep 5, 2014 90612756349:194 admin Aug 18, 2013 Sep 5, 2014 173110576350:194 admin Aug 18, 2013 Sep 5, 2014 88502736351:194 admin Aug 18, 2013 Sep 5, 2014 28573646352:194 admin Aug 18, 2013 Sep 5, 2014 25729006353:194 admin Aug 18, 2013 Sep 5, 2014 74936596356:194 admin Aug 18, 2013 Sep 5, 2014 146522386357:194 admin Aug 18, 2013 Sep 5, 2014 172279966358:194 admin Aug 18, 2013 Sep 5, 2014 105113296359:194 admin Aug 18, 2013 Sep 5, 2014 156712226360:194 admin Aug 18, 2013 Sep 5, 2014 162865196361:194 admin Aug 18, 2013 Sep 5, 2014 145539576362:194 admin Aug 18, 2013 Sep 5, 2014 124993436363:194 admin Aug 18, 2013 Sep 5, 2014 94050296364:194 admin Aug 18, 2013 Sep 5, 2014 39462956367:194 admin Aug 18, 2013 Nov 6, 2013 104714226368:194 admin Aug 18, 2013 Nov 6, 2013 104714226369:194 admin Aug 18, 2013 Sep 5, 2014 152258336370:194 admin Aug 18, 2013 Sep 5, 2014 116417506371:194 admin Aug 18, 2013 Sep 5, 2014 174421306372:194 admin Aug 18, 2013 Sep 5, 2014 82014446373:194 admin Aug 18, 2013 Sep 5, 2014 175528806374:194 admin Aug 18, 2013 Sep 5, 2014 82055386375:194 admin Aug 18, 2013 Sep 5, 2014 93438376376:194 admin Aug 18, 2013 Sep 5, 2014 86107046377:194 admin Aug 18, 2013 Sep 5, 2014 158805326378:194 admin Aug 18, 2013 Sep 5, 2014 175361916379:194 admin Aug 18, 2013 Sep 5, 2014 171064376380:194 admin Aug 18, 2013 Sep 5, 2014 183980336381:194 admin Aug 18, 2013 Sep 5, 2014 192211906382:194 admin Aug 18, 2013 Sep 5, 2014 153541506383:194 admin Aug 18, 2013 Sep 5, 2014 175566976384:194 admin Aug 18, 2013 Sep 5, 2014 18433305

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Alt ID(s) Title Year Author2008200020031995200520081992199619982005200520082008200720082007200819931999-- Not Found --1995200820062007200720012008

Quality [* Serum vitamin D

concentration and Ahn J., Peters U., Albanes D., Purdue MP., Abnet CC., Prostate cancer risk and

prediagnostic serum 25-Ahonen MH., Tenkanen L., Teppo L., Hakama M., A prospective study of

calcium intake from diet Al-Delaimy WK., Rimm E., Willett WC., Stampfer MJ., The influence of

menopause and hormonal Aloia JF., Vaswani A., Russo L., Sheehan M., Low-fat dairy consumption

and reduced risk of Alonso A., Beunza JJ., Delgado-Rodríguez M., Effect of vitamin D

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a randomized clinical trial Baron JA., Beach M., Wallace K., Grau MV., Plasma 25-hydroxyvitamin

D and 1,25-Bertone-Johnson ER., Chen WY., Holick MF., Hollis BW., Vitamin D

supplementation has Björkman M., Sorva A., Risteli J., Tilvis R.Body size and serum 25

hydroxy vitamin D Blum M., Dallal GE., Dawson-Hughes B.Maternal vitamin D

deficiency increases the Bodnar LM., Catov JM., Simhan HN., Holick MF., Vascular events in healthy

older women receiving Bolland MJ., Barber PA., Doughty RN., Mason B., Two-year randomized

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supplementation in Bortolotti M., Rudelle S., Schneiter P., Vidal H., Relation of calcium,

vitamin D, and dairy food Bostick RM., Potter JD., Sellers TA., McKenzie DR., Relation of calcium,

vitamin D, and dairy food Bostick RM., Kushi LH., Wu Y., Meyer KA., Sellers TA., Cinematics of fibroblast

spreading. I. Analysis of a Bliokh ZhL., Smolianinov VV.Prostate cancer and

prediagnostic levels of Braun MM., Helzlsouer KJ., Hollis BW., Comstock GW.Calcium, vitamin D

supplementation, and Brunner RL., Cochrane B., Jackson RD., Larson J., Effects of vitamin D

supplementation and Bunout D., Barrera G., Leiva L., Gattas V., de la Does vitamin D stop

inpatients falling? A Burleigh E., McColl J., Potter J.Calcium plus vitamin D

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20052004-- Not Found ---- Not Found --1996200620061994200420051991 Ford ES., Cooper RS.2007200820072008199620081996198519891995200320071999200520052003200319971986199919992004200120071994200819941997199620052007200620082009200420072008

Effects of calcium, dairy product, and vitamin D

Cheng S., Lyytikäinen A., Kröger H., Lamberg-Allardt Weight loss and calcium

intake influence calcium Cifuentes M., Riedt CS., Brolin RE., Field MP., Vitamin D and prostate

cancer: a prediagnostic Corder EH., Guess HA., Hulka BS., Friedman GD., Calcium chemoprevention

in colorectal cancer.Duris I., Hruby D., Pekarkova B., Huorka M., Dietary calcium, alcohol,

and incidence of treated Dwyer JH., Li L., Dwyer KM., Curtin LR., Feinleib M.Effect of 1-year dairy

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replacement on El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., Seasonal and geographical

variations in the growth Feliciano ES., Ho ML., Specker BL., Falciglia G., Plasma vitamin D

metabolites and risk of Feskanich D., Ma J., Fuchs CS., Kirkner GJ., Hankinson Calcium from diet and

supplements is associated Flood A., Peters U., Chatterjee N., Lacey JV., Risk factors for

hypertension in a national Plasma 25-hydroxyvitamin D levels and risk of

Forman JP., Giovannucci E., Holmes MD., Bischoff-Plasma 25-hydroxyvitamin

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serum vitamin D and Freedman DM., Looker AC., Chang SC., Graubard Serum levels of vitamin D

metabolites and breast Freedman DM., Chang SC., Falk RT., Purdue MP., Dietary factors and risk of

colon cancer: a Gaard M., Tretli S., Løken EB.Maternal vitamin D status

during pregnancy and Gale CR., Robinson SM., Harvey NC., Javaid MK., Circulating vitamin D

metabolites in relation to Gann PH., Ma J., Hennekens CH., Hollis Dietary vitamin D and

calcium and risk of Garland C., Shekelle RB., Barrett-Connor E., Criqui Serum 25-hydroxyvitamin

D and colon cancer: eight-Garland CF., Comstock GW., Garland FC., Helsing The influence of dairy

products on plasma uric Ghadirian P., Shatenstein B., Verdy M., Hamet P.Vitamin D, calcium

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calcium supplementation Grau MV., Baron JA., Sandler RS., Wallace K., Plasma 25-hydroxyvitamin

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and vitamin D with risk of Hartman TJ., Albert PS., Snyder K., Slattery ML., The impact of calcium and

dairy product consumption Harvey-Berino J., Gold BC., Lauber R., Starinski A.Gestational calcium

supplementation and Hatton DC., Harrison-Hohner J., Coste S., Reller Human serum 25-

hydroxycholecalciferol Heaney RP., Davies KM., Chen TC., Holick MF., Long-term vitamin D3

supplementation may Heikkinen AM., Tuppurainen MT., Colon cancer and dietary

fat, phosphorus, and Heilbrun LK., Hankin JH., Nomura AM., Prospective study of

calcium, potassium, and Iso H., Stampfer MJ., Manson JE., Rexrode K., Prospective study of

calcium, potassium, and Iso H., Stampfer MJ., Manson JE., Rexrode K., Plasma levels of 25-

hydroxyvitamin D, 1,25-Jacobs ET., Giuliano AR., Martínez ME., Hollis BW., Prospective study on milk

products, calcium and Järvinen R., Knekt P., Hakulinen T., Aromaa A.Nutritional status and

subsequent all-cause Jia X., Aucott LS., McNeill G.Dietary intakes,

anthropometric Johnson AA., Knight EM., Edwards CH., Oyemade Calcium intake and the

outcome of short-term Kabrnová-Hlavatá K., Hainer V., Gojová M., Fermented dairy products,

calcium, and colorectal Kampman E., Goldbohm RA., van den Brandt PA., Prospective study of diet

and female colorectal Kato I., Akhmedkhanov A., Koenig K., Toniolo PG., Calcium, vitamin D, and

dairy foods and the Kearney J., Giovannucci E., Rimm EB., Ascherio A., Dietary calcium,

phosphorus, vitamin D, Kesse E., Boutron-Ruault MC., Norat T., Riboli E., Dairy products, calcium

and the risk of breast Kesse-Guyot E., Bertrais S., Duperray B., Arnault N., Dairy products, calcium

and prostate cancer risk.Koh KA., Sesso HD., Paffenbarger RS., Lee IM.Dairy product, saturated

fatty acid, and calcium Kurahashi N., Inoue M., Iwasaki M., Sasazuki S., Calcium plus vitamin D

supplementation and LaCroix AZ., Kotchen J., Anderson G., Brzyski R., Girls on a high-calcium

diet gain weight at the Lappe JM., Rafferty KA., Davies KM., Lypaczewski Vitamin D and calcium

supplementation reduces Lappe JM., Travers-Gustafson D., Davies KM., Calcium and vitamin d

supplementation Lappe J., Cullen D., Haynatzki G., Recker R.,

200620062008200920071995 Lijnen P., Petrov V.200520072006200720071986200820052002198719882006198120032005200820082006200620012006 Moschonis G., Manios Y.200920091998200720072007200720072007200920011999200020052003200719972004199919952002

Calcium and dairy food intakes are inversely

Larsson SC., Bergkvist L., Rutegård J., Giovannucci Calcium and dairy food

intakes are inversely Larsson SC., Bergkvist L., Rutegård J., Giovannucci Magnesium, calcium,

potassium, and sodium Larsson SC., Virtanen MJ., Mars M., Männistö S., Long-term dietary calcium

intake and breast cancer Larsson SC., Bergkvist L., Wolk A.A prospective study of

plasma vitamin D Li H., Stampfer MJ., Hollis JB., Mucci LA., Gaziano JM., Dietary calcium, blood

pressure and cell Intakes of calcium and vitamin D and risk of

Lin J., Zhang SM., Cook NR., Manson JE., Lee IM., Intakes of calcium and

vitamin D and breast Lin J., Manson JE., Lee IM., Cook NR., Buring JE., Calcium supplementation

for 1 y does not reduce Lorenzen JK., Mølgaard C., Michaelsen KF., Astrup A.Preventing fractures

among older people living Lyons RA., Johansen A., Brophy S., Newcombe RG., Supplementation with

calcium + vitamin D Major GC., Alarie F., Doré J., Phouttama S., Tremblay Vitamin D

supplementation in Mallet E., Gügi B., Brunelle P., Hénocq A., Basuyau JP., Effect of calcium and

vitamin D supplementation Margolis KL., Ray RM., Van Horn L., Manson JE., Allison Dietary and serum

vitamins and minerals as Marniemi J., Alanen E., Impivaara O., Seppänen Calcium, vitamin D, and

risk of adenoma Martínez ME., Marshall JR., Sampliner R., Wilkinson J., Effect of calcium and

vitamin D supplementation Marya RK., Rathee S., Manrow M.Effect of vitamin D

supplementation during Marya RK., Rathee S., Dua V., Sangwan K.Vitamin D2 dose required

to rapidly increase 25OHD Mastaglia SR., Mautalen CA., Parisi MS., Oliveri B.Vitamin D supplements

enhance weight gain and Maxwell JD., Ang L., Brooke OG., Brown IR.Calcium, vitamin D, dairy

products, and risk of McCullough ML., Robertson AS., Rodriguez Dairy, calcium, and

vitamin D intake and McCullough ML., Rodriguez C., Diver WR., Feigelson 25-hydroxyvitamin D

levels and the risk of Melamed ML., Michos ED., Post W., Astor B.Dietary calcium and

vitamin D intakes in Mishra G., McCormack V., Kuh D., Hardy R., Stephen Dairy products, calcium

and prostate cancer risk.Koh KA., Sesso HD., Paffenbarger RS., Lee IM.Maternal 25-

hydroxyvitamin D and Morley R., Carlin JB., Pasco JA., Wark JD.Nutrient intake and

hypertensive disorders of Morris CD., Jacobson SL., Anand R., Ewell MG., Skeletal site-dependent

response of bone mineral A double-blind, randomized, placebo-

Nagpal J., Pande JN., Bhartia A.Supplements of 20

microg/d cholecalciferol Nelson ML., Blum JM., Hollis BW., Rosen C., Serum vitamin D

metabolite levels and the Nomura AM., Stemmermann GN., Lee J., Calcium and vitamin D

intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.Diet during pregnancy and

risk of preeclampsia or Oken E., Ning Y., Rifas-Shiman SL., Rich-Edwards Plasma vitamin D and risk

of colorectal cancer: the Otani T., Iwasaki M., Sasazuki S., Inoue M., Calcium and vitamin D

intake and risk of Park SY., Murphy SP., Wilkens LR., Nomura AM., Calcium, dairy foods, and

risk of incident and fatal Park Y., Mitrou PN., Kipnis V., Hollenbeck A., Calcium, vitamin D, and

dairy product intake and Park SY., Murphy SP., Wilkens LR., Stram DO., Dairy food, calcium, and

risk of cancer in the NIH-Park Y., Leitzmann MF., Subar AF., Hollenbeck A., Effects of a short-term

vitamin D(3) and calcium Pfeifer M., Begerow B., Minne HW., Nachtigall D., Diet and risk of colorectal

cancer in a cohort of Pietinen P., Malila N., Virtanen M., Hartman TJ., Plasma 1,25-dihydroxy-

and 25-hydroxyvitamin D Platz EA., Hankinson SE., Hollis BW., Colditz GA., Effects of calcium

supplementation on body Reid IR., Horne A., Mason B., Ames R., Bava U., Calcium, dairy products,

and risk of prostate cancer Rodriguez C., McCullough ML., Mondul AM., Jacobs Meat and dairy

consumption and Rohrmann S., Platz EA., Kavanaugh CJ., Thuita L., Prospective evaluation of

dietary and other Ross RK., Yuan JM., Henderson BE., Park J., Serum parathyroid

hormone is associated Sambrook PN., Chen JS., March LM., Cameron ID., Animal products, calcium

and protein and prostate Schuurman AG., van den Brandt PA., Dorant E., Effect of winter oral

vitamin D3 Scragg R., Khaw KT., Murphy S.Intake of dairy products,

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20062006199320081990200920061997200219872003200520062008198620071992200620062006200820081996200819971987200220071995199820082008

Dietary intake of calcium, fiber and other

Shin A., Li H., Shu XO., Yang G., Gao YT., Zheng Vitamin D intake and the

risk for pancreatic cancer Skinner HG., Michaud DS., Giovannucci E., Willett Calcium intake and 28-

year gastro-intestinal Slob IC., Lambregts JL., Schuit AJ., Kok FJ.Supplementation with

cholecalciferol does not Sneve M., Figenschau Y., Jorde R.The influence of dairy and

nondairy calcium on Stemmermann GN., Nomura A., Chyou PH.Serum vitamin D and risk

of pancreatic cancer in the Stolzenberg-Solomon RZ., Hayes RB., Horst RL., A prospective nested case-

control study of vitamin D Stolzenberg-Solomon RZ., Vieth R., Azad A., Pietinen Serum levels of vitamin D

metabolites and the Tangrea J., Helzlsouer K., Pietinen P., Taylor P., Hollis Dietary calcium and

vitamin D intake and risk Terry P., Baron JA., Bergkvist L., Holmberg L., Dietary calcium intake and

blood pressure in Thomsen K., Nilas L., Christiansen C.Effect of four monthly oral

vitamin D3 Trivedi DP., Doll R., Khaw KT.Dairy, calcium, and

vitamin D intakes and Tseng M., Breslow RA., Graubard BI., Ziegler RG.Dietary intake of calcium

in relation to mortality Umesawa M., Iso H., Date C., Yamamoto A., Dietary calcium intake and

risks of stroke, its Umesawa M., Iso H., Ishihara J., Saito I., Kokubo Oral calcium and blood

pressure: a controlled van Beresteyn EC., Schaafsma G., de Waard Childhood dairy intake and

adult cancer risk: 65-y van der Pols JC., Bain C., Gunnell D., Smith GD., Calcium intake and 28-

year cardiovascular and Van der Vijver LP., van der Waal MA., Weterings KG., Low serum concentrations

of 25-hydroxyvitamin D in Visser M., Deeg DJ., Puts MT., Seidell JC., Lips P.Calcium plus vitamin D

supplementation and the Wactawski-Wende J., Kotchen JM., Anderson GL., High-dose vitamin D3

supplementation in a Wagner CL., Hulsey TC., Fanning D., Ebeling M., Dietary intake of dairy

products, calcium, and Wang L., Manson JE., Buring JE., Lee IM., Sesso Vitamin D deficiency and

risk of cardiovascular Wang TJ., Pencina MJ., Booth SL., Jacques PF., Effect of longterm placebo

controlled calcium Weisgerber UM., Boeing H., Owen RW., Waldherr Is ischemic stroke risk

related to folate status or Weng LC., Yeh WT., Bai CH., Chen HJ., Chuang SY., Efficacy of

nonpharmacologic Whelton PK., Kumanyika SK., Cook NR., Cutler JA., Alcohol, physical activity

and other risk factors for Wu AH., Paganini-Hill A., Ross RK., Henderson BE.Calcium intake and risk of

colon cancer in women Wu K., Willett WC., Fuchs CS., Colditz GA., A nested case control

study of plasma 25-Wu K., Feskanich D., Fuchs CS., Willett WC., Hollis Lack of blood pressure

effect with calcium and Yamamoto ME., Applegate WB., Klag MJ., Borhani NO., A prospective cohort study

of intake of calcium, Zheng W., Anderson KE., Kushi LH., Sellers TA., Effects of calcium and

vitamin D supplementation Zhu K., Devine A., Dick IM., Wilson SG., Prince RL.Randomized controlled

trial of the effects of Zhu K., Bruce D., Austin N., Devine A., Ebeling PR.,

Status NotesResults needs to

Men, Women

Name Emailleadlead Mei Chunglead nira hadarlead Ethan Balkleadleadlead Jens Japleadleadlead

User Role SRDR

[email protected]_chun.chung@tuftnhadar@tuftsmedicalcebalk@tuftsmedicalceMeghan

Ingerickmeghan_ingerick@broAneesa

[email protected][email protected]

[email protected]

[email protected]

[email protected]

Study ID:EF ID Creator Create Date PMID6304:194 admin Aug 18, 2013 Sep 5, 2014 185059676305:194 admin Aug 18, 2013 Sep 5, 2014 110758746306:194 admin Aug 18, 2013 Sep 5, 2014 126632776307:194 admin Aug 18, 2013 Sep 5, 2014 78928826308:194 admin Aug 18, 2013 Sep 5, 2014 162804276309:194 admin Aug 18, 2013 Sep 5, 2014 182086366313:194 admin Aug 18, 2013 Sep 5, 2014 97435116314:194 admin Aug 18, 2013 Sep 5, 2014 157673346315:194 admin Aug 18, 2013 Sep 5, 2014 161034506316:194 admin Aug 18, 2013 Sep 5, 2014 179650376317:194 admin Aug 18, 2013 Sep 5, 2014 186895596318:194 admin Aug 18, 2013 Sep 5, 2014 175359856319:194 admin Aug 18, 2013 Sep 5, 2014 181983946320:194 admin Aug 18, 2013 Sep 5, 2014 172438666321:194 admin Aug 18, 2013 Sep 5, 2014 188427716322:194 admin Aug 18, 2013 Sep 5, 2014 83334126323:194 admin Aug 18, 2013 Sep 5, 2014 99219606325:194 admin Aug 18, 2013 Sep 5, 2014 76128036326:194 admin Aug 18, 2013 Sep 5, 2014 187553196327:194 admin Aug 18, 2013 Sep 5, 2014 167979036328:194 admin Aug 18, 2013 Sep 5, 2014 176564206329:194 admin Aug 18, 2013 Sep 5, 2014 175025306330:194 admin Aug 18, 2013 Sep 5, 2014 115666566331:194 admin Aug 18, 2013 Sep 5, 2014 190016016333:194 admin Aug 18, 2013 Sep 5, 2014 162804476334:194 admin Aug 18, 2013 Sep 5, 2014 152130386335:194 admin Aug 18, 2013 Sep 5, 2014 82200926336:194 admin Aug 18, 2013 Sep 5, 2014 86824536337:194 admin Aug 18, 2013 Sep 5, 2014 88906616338:194 admin Aug 18, 2013 Sep 5, 2014 171895526339:194 admin Aug 18, 2013 Sep 5, 2014 162782626340:194 admin Aug 18, 2013 Sep 5, 2014 80781156341:194 admin Aug 18, 2013 Sep 5, 2014 153424526342:194 admin Aug 18, 2013 Sep 5, 2014 156684856344:194 admin Aug 18, 2013 Sep 5, 2014 173720316345:194 admin Aug 18, 2013 Sep 5, 2014 188386236346:194 admin Aug 18, 2013 Sep 5, 2014 179715266347:194 admin Aug 18, 2013 Sep 5, 2014 183814726348:194 admin Aug 18, 2013 Sep 5, 2014 90612756349:194 admin Aug 18, 2013 Sep 5, 2014 173110576350:194 admin Aug 18, 2013 Sep 5, 2014 88502736351:194 admin Aug 18, 2013 Sep 5, 2014 28573646352:194 admin Aug 18, 2013 Sep 5, 2014 25729006353:194 admin Aug 18, 2013 Sep 5, 2014 74936596356:194 admin Aug 18, 2013 Sep 5, 2014 146522386357:194 admin Aug 18, 2013 Sep 5, 2014 172279966358:194 admin Aug 18, 2013 Sep 5, 2014 10511329

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Alt ID(s) Title Year Author20082000200319952005200819982005200520082008200720082007200819931999199520082006200720072001200820052004-- Not Found ---- Not Found --1996200620061994200420052007200820072008199620081996198519891995200320071999

Serum vitamin D concentration and

Ahn J., Peters U., Albanes D., Purdue MP., Abnet CC., Prostate cancer risk and





supplementation on bone Andersen R., Mølgaard C., Skovgaard LT., Brot C., Intake of potassium,











vitamin D, and dairy food Bostick RM., Kushi LH., Wu Y., Meyer KA., Sellers TA., Prostate cancer and







supplementation and the Chlebowski RT., Johnson KC., Kooperberg C., Effects of calcium, dairy

product, and vitamin D Cheng S., Lyytikäinen A., Kröger H., Lamberg-Allardt Weight loss and calcium









supplements is associated Flood A., Peters U., Chatterjee N., Lacey JV., Plasma 25-hydroxyvitamin

D levels and risk of Forman JP., Giovannucci E., Holmes MD., Bischoff-Plasma 25-hydroxyvitamin









products on plasma uric Ghadirian P., Shatenstein B., Verdy M., Hamet P.Vitamin D, calcium

supplementation, and Grau MV., Baron JA., Sandler RS., Haile RW., Prolonged effect of


D responses of younger Harris SS., Dawson-Hughes B., Perrone GA.

2005200520032003199719862004200120071994200819941997199620052007200620082009200420072008200620062008200920071995 Lijnen P., Petrov V.20052007200620072007198620082005200219871988200619812003200520082008200620062001

The association of calcium and vitamin D with risk of

Hartman TJ., Albert PS., Snyder K., Slattery ML., The impact of calcium and





fat, phosphorus, and Heilbrun LK., Hankin JH., Nomura AM., Plasma levels of 25-
















supplementation Lappe J., Cullen D., Haynatzki G., Recker R., Calcium and dairy food

intakes are inversely Larsson SC., Bergkvist L., Rutegård J., Giovannucci Calcium and dairy food

























hypertensive disorders of Morris CD., Jacobson SL., Anand R., Ewell MG.,

2006 Moschonis G., Manios Y.20092009199820072007200720072007200720092001199920002005200320071997200419991995200220062006199320082009200619972002198720032005200620081986200720062006200620081996200819971987200220071995

Skeletal site-dependent response of bone mineral A double-blind, randomized, placebo-





















calcium, and vitamin d and Shin MH., Holmes MD., Hankinson SE., Wu K., Dietary intake of calcium,

fiber and other Shin A., Li H., Shu XO., Yang G., Gao YT., Zheng Vitamin D intake and the



cholecalciferol does not Sneve M., Figenschau Y., Jorde R.Serum vitamin D and risk











adult cancer risk: 65-y van der Pols JC., Bain C., Gunnell D., Smith GD., Low serum concentrations



supplementation in a Wagner CL., Hulsey TC., Fanning D., Ebeling M., Vitamin D deficiency and








effect with calcium and Yamamoto ME., Applegate WB., Klag MJ., Borhani NO.,

199820082008

A prospective cohort study of intake of calcium,

Zheng W., Anderson KE., Kushi LH., Sellers TA., Effects of calcium and



Inclusion Exclusion

1986 SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() NIH SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()1986 SUBVALUE()

nd SUBVALUE()Gov SUBVALUE()

RCT SUBVALUE() nd SUBVALUE()nd SUBVALUE() nd SUBVALUE() NIH SUBVALUE()

nd SUBVALUE() NIH SUBVALUE()RCT SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()

1986 SUBVALUE() NCI SUBVALUE()1986 SUBVALUE() NCI SUBVALUE()1974 SUBVALUE()

nd SUBVALUE() WHI SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() none SUBVALUE() WHI SUBVALUE() Govt SUBVALUE()

nd SUBVALUE() 1995 SUBVALUE()WHI SUBVALUE() Gov SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() NIH SUBVALUE()

nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()nd SUBVALUE()

nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() - SUBVALUE()

1976 SUBVALUE() nd SUBVALUE()

AHA SUBVALUE()nd SUBVALUE() 1989 SUBVALUE()

NIH SUBVALUE()NHSS SUBVALUE() nd SUBVALUE()

nd SUBVALUE() - SUBVALUE()nd SUBVALUE() NIH SUBVALUE()

nd SUBVALUE()RCT SUBVALUE() 1994 SUBVALUE() none SUBVALUE()

nd SUBVALUE() 1988 SUBVALUE() nd SUBVALUE()RCT SUBVALUE()RCT SUBVALUE() nd SUBVALUE() - SUBVALUE() USDA SUBVALUE()

Study Design

Enrollment Years

Trial or Cohort

Funding SourceCase-cohort study

SUBVALUE()Non-Hispanic white males, at

No prior history of prostate cancer

1993-2001 SUBVALUE()

Prostate, Lung, Colorectal, and

NIH: National Cancer Institute, Case-cohort study

SUBVALUE()Employees in two Finnish

Previously clinically detected


Helsinki Heart Study SUBVALUE()

Finnish Cancer Foundation, Yrjo Cohort Study

SUBVALUE()Men, 40-75 y, health

Kcal intake outside 800-4200

Health Professionals

Gov t SUBVALUE()Healthy white

women between 6 Cohort Study SUBVALUE()

University graduates or

History of CVD, cancer, DM,

12/99-1/2002 SUBVALUE()

U Navarra Follow-up Study

Govt, University SUBVALUE()General Pakistani

immigrants Medications known to affect

Jan 2002 to Nov 2002 SUBVALUE()Cohort study

SUBVALUE()Male health professionals, 40-

Calorie intake <800 or


Gov t SUBVALUE()RCT-post hoc (Ca

suppl) Cohort Men Details were referred to original

1988 (mentioned) 1992 (inferred)

From Baron NEJM 1999 paper:

NCI and GlaxoSmithKlein Case-cohort study

SUBVALUE()43 to 69 years old female registered

Those who had cancer before

Original cohort 1976 Study cohort

Nurses health study SUBVALUE()Age 65 years,

chronically Markedly elevated creatinine levels

September to December 2005

A special governmental 2 /subgroup

analysis of an healthy 65 y; subgroup from a

conditions/medications Nested case-

control study nulliparity; no preexisting


Pregnancy Exposures & Postmenopausal

>5 yr, age 55 y, Osteoporosis treatment, Ca

~2000 SUBVALUE()

Same as Reid 2005 SUBVALUE()

Govt (suppl supplied by Healthy women

60 years of age Clinical osteoporosis or

UK Food Standards Agency BMI > 27, Ca

intakes < 800 BMI < 27, high intake of Ca

Nestec SA, Switzerland Cohort study

SUBVALUE()Women aged 55-69 Resided in

Hx of cancer (excl. skin cancer)

Iowa Women s Health Study Cohort study

SUBVALUE()Women 55-69 y, post-menstrual

Ischemic heart disease,

Iowa Women s Health Study Case-cohort study

SUBVALUE()Resident of Washington

None (implied) SUBVALUE()

(Washington County)

nd Corresponding/leaRCT-post hoc**

SUBVALUE()Postmenopausal women (50 to 79


NIH, National Heart, Lung and Subjects with a

serum vitamin D Patients were aged 65 years or

Subjects with hypercalcemica, Women 50-79 y,

postmenopausal 1994-1999 SUBVALUE()Cohort

SUBVALUE()Male physicians, subjects who

Physician s Health Study

The CaP Cure Young Investigator RCT Case-cohort

study SUBVALUE()Post menopausal enrolled in WHI

Women with h/o hypercalcemia,

Until March 2005 SUBVALUE()10-12 y old girls;

Tanner 1 to 2; serious medical conditions;

government and industry Weight-stable,

overweight, post-Women with disease states,

2000-2003 SUBVALUE()Case-cohort study

SUBVALUE()Ambulatory, generally healthy

Orientals excluded (for

Vit D screening 1964-71 Cancer

(Kaiser Permanente)

NCI National MS Society Other intervention

study SUBVALUE()Patients with adenomatous

Group with polyps: nd Patients with Cohort study

SUBVALUE()NHANES I 25-74 yo White or black.

HTN at baseline SUBVALUE()

1971-75 SUBVALUE()

NHANES I SUBVALUE()RCT-post hoc**

SUBVALUE()Calcium intakes <800mg/d and

> 20% overweight or 15%

Dairy Management, Inc. 10-17yr girls in

four schools from 2001-2002 SUBVALUE()37 wk gestation

SUBVALUE()gastrointestinal disease;

Fall 1986; Spring 1987 SUBVALUE()

non-profit SUBVALUE()Case-cohort study

SUBVALUE()Ongoing cohort study with

Previous non-cutaneous cancer

Nurses Health Study SUBVALUE()Cohort study

SUBVALUE()Women found to or not to have

Failed to complete dietary


The Breast Cancer Detection

NCI and American Cancer Society Cohort study

SUBVALUE()-participant of HPFS or NHS who

-Cases from case-control studies

NHS: 1990 1998 HPFS: 1994 - 2002

Health Professionals Case-cohort study

SUBVALUE()Fasting for 8 hours; no

Nurses Health Study 2

American Heart Association & Cohort study

SUBVALUE()Noninstitutionalized US population,

No 25(OH)D measurement


NHANES III SUBVALUE()

NIH/NCI, USPHS/DHHS Case-cohort study

SUBVALUE()Cases: All participants of

History of one of the four PLCO

November 1993 and July 2001

Prostate, Lung, Colorectal, and Cohort study

SUBVALUE()Attended NHSS health screening

Previous cancer (n=617)

1977-1983 SUBVALUE()Cohort study

SUBVALUE()Caucasian women 16 y; singleton

1991-92 SUBVALUE()

non-profit SUBVALUE()Case-cohort study

SUBVALUE()US male physicians

Prior history of MI, stroke, TIA,

Physicians Health Study Cohort study

SUBVALUE()Randomly selected from the

Age at first examination less


Western Electric Health Study

American heart association Case-cohort study

SUBVALUE()Community volunteer cohort

Cases: Non-white cases Previous

1974 (Sep-Nov) SUBVALUE()

NCI, The Dairy Bureau of Canada, Post-menopausal

nuns 50 y Acute illness, medical

Dairy Bureau SUBVALUE()Post hoc analysis

of an existing RCT Subjects had at least one

Calcium Polyp Prevention Study Subjects had at

least one Subjects diet during Calcium


Calcium Polyp Prevention Study

National Institute of Health men 20-35 y or

60-75 y travel to southern areas in last

nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() 1996 SUBVALUE()RCT SUBVALUE() nd SUBVALUE() - SUBVALUE()RCT SUBVALUE()

nd SUBVALUE()nd SUBVALUE()nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE() nd SUBVALUE()nd SUBVALUE() nd SUBVALUE()nd SUBVALUE() none SUBVALUE()1986 SUBVALUE()

NCI SUBVALUE()1986 SUBVALUE()1990 SUBVALUE()

Gov SUBVALUE()

WHI SUBVALUE()nd SUBVALUE() - SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() none SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()

RCT SUBVALUE() none SUBVALUE() None SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() - SUBVALUE()RCT SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() none SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() WHI SUBVALUE() NIH SUBVALUE()

nd SUBVALUE()nd SUBVALUE() NCI SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() - SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE() - SUBVALUE() nd SUBVALUE()RCT SUBVALUE() - SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() - SUBVALUE()

nd SUBVALUE()nd SUBVALUE()

Gov SUBVALUE()NIH SUBVALUE()

- SUBVALUE()nd SUBVALUE() nd SUBVALUE()

Cohort study Participants are

Subjects 35 yr with 1 or more

Subjects must not have had resected


The Polyp Prevention Trial Age 18 to 60

years, BMI History of major medical or

National Dairy Council, Northeast Completed CPEP

trial protocol; in CKD, calciuria, hematuria,

Calcium for Prevention of

GSK NIH SUBVALUE()men in good

general health, vitamin supplement

Health Future Foundation 47-56 yo women,

Last menstrual Contraindications for HRT

>=1989 SUBVALUE()

Kuopio Osteoporosis Risk

Schering, Professional Case-cohort study

SUBVALUE()Japanese men living on the Oahu

Food intake determined by a


NCI/NIH SUBVALUE()Case-cohort study

SUBVALUE()Caucasian, male SUBVALUE()

1983, 1989 SUBVALUE()

Nutritional Prevention of

National Cancer Institute Cohort study

SUBVALUE()Participant of a large-scale health


SUBVALUE()75 y or older SUBVALUE()

Terminal illness Severe dementia


SUBVALUE()African American women; 16-35 y;

DM, sickle cell, thalassemia, Hb C

NICHD SUBVALUE()Other intervention

study SUBVALUE()-overweight or obese -female

-diabetes -uncompensated

Supported by grants IGA Cohort study

SUBVALUE()Age 55 to 69 participant of

History of cancer (excluding skin

Netherlands Cohort Study on

Netherlands Digestive Cohort study

SUBVALUE()Women breast exam participants

Prior colorectal cancer (n=58) 8


New York Univ. Women s Health Cohort study

SUBVALUE()Male health professionals Age

Implausibly high (4200-)/low (-800)

The Health Professionals

American Cancer Society, NIH, Cohort study

SUBVALUE()Women living in France, aged 40 to

Subjects who had reported a cancer

Etude Epid miologique aupr s

French League against Cancer, RCT-post hoc

(cohort follow-up 12741 subjects enrolled in the

Subjects with a recent cancer


SU.VI.MAX trial SUBVALUE()Cohort study

SUBVALUE()Harvard male undergraduates

baseline cancer or no data on dairy

1960 s SUBVALUE()

Harvard Alumni Health Study

government SUBVALUE()Cohort study

SUBVALUE()Male Japanese residents age 40-

History of prostate cancer, extreme

Cohort I launched in 1990, Cohort II

Japan Public Health Center-

Japanese Ministry of Health RCT-post hoc**

Case-cohort study Postmenopausal women aged 50-

A predicted survival of less


National Heart, Lung and Blood RCT-post hoc

SUBVALUE()girl scouts SUBVALUE()

significant health problems (see list

Natl Institute of Nursing >55 y women; no

cancer; mentally More detailed inclusion criteria Women entered

basic training at May 2001 to march 2006

Department of Defense Bone Cohort study

SUBVALUE()Men aged 45-79 Resides in

Missing/erroneous registration #

1997 (Autumn) SUBVALUE()

The Cohort of Swedish Men

the Swedish Cancer Cohort study

SUBVALUE()Men aged 45-79 Resides in

Missing/erroneous registration #

1997 (Autumn) SUBVALUE()

The Cohort of Swedish Men

the Swedish Cancer Cohort Study

SUBVALUE()Male smokers, 50-69 y SUBVALUE()

Nonmelanoma cancer, other


ATBC study SUBVALUE()

Gov t SUBVALUE()Cohort study

SUBVALUE()-Women born between 1917 and

-erroneous or missing national


Swedish Mammography

Swedish Cancer Foundation, Case-cohort study

SUBVALUE()Male physicians SUBVALUE()

Hx of MI, stroke, hx of TIA, unstable

1982 - 2000 SUBVALUE()

Physicians Health Study

NIH, US Army Medical Research Male, Normal

Normotensive (not <1994 SUBVALUE()

nd Supplements provided by Cohort study

Participants are US female professionals aged

Excluded (n=2900) did not

1993 (RCT) SUBVALUE()

The Women s Health Study (a

NCI and National Heart, Lung, and Cohort study of

subjects enrolled 39 876 women 45 years or older who

8389 who provided

During 1993 and 1995 SUBVALUE()

Women s Health Study SUBVALUE()

Gov t SUBVALUE()12y 6 mo old

girls with Danish academic and industry All residents living

in care homes People already receiving 400 IU

December 2000 and January 2003

The Wales Office of Research and Women with low

Ca intake (800 mg Ca supplementation

Wyeth, professional term pregnancy,

white, lived in Women aged 50 to 79 years

Women with < 3years of


SUBVALUE()65-99 in 1986-87. Around Turku,

Men<75 in NH Women<70 in NH

1986-87 SUBVALUE()

(Turku, Finland) SUBVALUE()Cohort study

Participants are Men and women 40-80 years of age

Individuals with a personal history of

Wheat Bran Fiber (WBF) trial pregnancy

SUBVALUE()pregnancy SUBVALUE()

preeclampsia, antepartum 50-70 y women;

menopause 1 y; vit D or meds that affect mineral

winter, spring 2002 SUBVALUE()

non-profit and industry pregnant Asians

SUBVALUE()government SUBVALUE()Cohort study

SUBVALUE()Members of CPS II who resided in 21

Men and women lost to follow (until


Cancer Prevention Study (CPS) II Cohort study

SUBVALUE()Women from the CPS II Nutrition

Women who were lost to follow-up

1992- 1993 SUBVALUE()

CPS II Nutrition Cohort Cohort study

SUBVALUE()Adults 20 years or older who had a

Did not have complete data on

Oct 1988-Oct 1994 SUBVALUE()

NHANES III SUBVALUE()

NIH; PJ Schafer CVD Research Cohort study

SUBVALUE()Women from the Medical MRC

Men from the cohort

Since 1946 at birth ages 53 y

Medical MRC NSHD, UK Cohort study

SUBVALUE()male smokers ( 5 cigarettes/d); 50-

previous history of cancer (except for


Alpha-Tocopherol, Beta-Carotene Cohort study

SUBVALUE()Pregnant <16 wk gestation

multiple pregnancies;



SUBVALUE()pregnant women SUBVALUE()

Calcium for Preeclampsia

NICHHD SUBVALUE()

RCT SUBVALUE() 2004 SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE()RCT SUBVALUE() 2005 SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE() 1976 SUBVALUE()

NCI SUBVALUE()

RCT SUBVALUE() 1997 SUBVALUE() - SUBVALUE()nd SUBVALUE()1976 SUBVALUE() NIH SUBVALUE()

RCT SUBVALUE()nd SUBVALUE()

1989 SUBVALUE()None SUBVALUE() NCI SUBVALUE()

1999 SUBVALUE() nd SUBVALUE()-male SUBVALUE()

RCT SUBVALUE() None SUBVALUE() nd SUBVALUE()nd SUBVALUE() 1980 SUBVALUE()

NIH SUBVALUE()

nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE()

PLCO SUBVALUE() NIH SUBVALUE()NIH SUBVALUE()nd SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()RCT SUBVALUE() nd SUBVALUE()

nd SUBVALUE()

1990 SUBVALUE()RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

1996 SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() - SUBVALUE()nd SUBVALUE()

RCT SUBVALUE() nd SUBVALUE() nd SUBVALUE()

RCT SUBVALUE() TOHP SUBVALUE() nd SUBVALUE()1982 SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE() 1986 SUBVALUE()RCT SUBVALUE() nd SUBVALUE()

Greek postmenopausal

Women diagnosed having a T-score

Friesland Foods Hellas Male, apparently

healthy , Fasting plasma glucose > 7.0


Indian Council of Medical Research, Women aged 19-

35 y, living in the Pregnant women, Women planned Case-cohort study

SUBVALUE()men with available blood

baseline prostate cancer;


Honolulu Heart Program


SUBVALUE()Registered nurses 30-55y in the

The Nurses Health Study

National Institute of Health Cohort study

SUBVALUE()pregnancy SUBVALUE()

no outpatient medical records;


Project Viva SUBVALUE()

NIH and others SUBVALUE()Case-cohort study

SUBVALUE()Residents living in several

Cases: Non-adenocarcinoma

1990 (Cohort 1) 1993 (Cohort 2)

The Japan Public Health Centre-

Ministry of Health, Labour, and Cohort study

SUBVALUE()Adults aged 45-75 years from five

Participants who are not in one of


Multiethnic Cohort Study SUBVALUE()


SUBVALUE()AARP members (50-71);

questionnaires completed by


(NIH)-AARP Diet & Health Study Cohort study

SUBVALUE()Male adults aged 45-75 years from

Not in one of the specified ethnic


Multiethnic Cohort Study SUBVALUE()


SUBVALUE()AARP members in 6 specific states

GENERAL***** Provided duplicate


NIH-AARP Diet and Health Study (NIH-

NIH (US) SUBVALUE()25(OH)D < 50

nmol/L -Hypercalcemia or 1

Strathmann, Inc., which markets vit Cohort study

Based on data Male smokers, 50-69 years of age at

History of cancer or other serious

Alpha-Tocopherol, Beta-Carotene

US NCI SUBVALUE()Case-cohort study

SUBVALUE()Participants of NHS (i.e., female

Cases: hyperplastic and

Nurses health study SUBVALUE()5 y post-

menopausal, age Osteoporosis therapy, Ca

~2000 SUBVALUE()

Same as Bolland 2008 SUBVALUE()

Govt (suppl supplied by Cohort study

SUBVALUE()-residing in one of 21 states with

-men with a history of cancer -


Cancer Prevention Study II Nutrition Cohort study

SUBVALUE()men; completed FFQ SUBVALUE()

<35 y in 1989; baseline cancer;

CLUE II study SUBVALUE()

government SUBVALUE()Case-cohort study

SUBVALUE()Men 45-64 yo at screening Cases:

History of cancer SUBVALUE()


SUBVALUE()65 y; resides in nursing homes or

bedridden; bilateral

Fracture Risk Epidemiology in Case-cohort study

SUBVALUE()-Hx of cancer (except skin


Netherlands Cohort Study

Dutch Cancer Society -Subjects

recruited from -vit D medication/supple

Dec. 1991 Jan. 1992 SUBVALUE()Cohort study

SUBVALUE()Registered nurses from 11 states in

Nurses Health Study SUBVALUE()

National cancer institute, national Cohort study

SUBVALUE()Women between the ages of 40 and

Subjects who had a previous history

March 1997 to May 2000

Shanghai Women s Health Study Cohort study

SUBVALUE()Nurses Healthy Study (NHS):

Prior cancers, except

NHS: 1984 HPFS: 1986 SUBVALUE()

1. NHS 2. HPFS SUBVALUE()

NIH and NHS s grant SUBVALUE()Cohort study

SUBVALUE()All civil servants in Amsterdam, aged

Subjects without information on

1953-1954 SUBVALUE()-men and women -

21-70 yrs old -BMI - diabetes, hx of MI, angina


The Northern Norway Regional Case-cohort study

SUBVALUE()Men and women, aged 55 to 74 y,

A personal history of one of the 4

November 1993 July 2001 Case-cohort study

SUBVALUE()All cases of pancreatic cancer

1) history of malignancy other

Trial enroll: 1985 1988 Cases

Alpha-Tocopherol, Beta-Carotene Post-hoc Case-

cohort study on a Participants of ATBC study Male

No serum controls (2 controls for 2


ATBC study SUBVALUE()Cohort study

SUBVALUE()Women born between 1914-

Women > 76 years old; women


Swedish Mammography

Swedish Cancer Society and Early post-

menopausal Men & women*** 65-85 years***

Already Vit D supplements

06/96-03/97 SUBVALUE()

Medical Research Council, UK Cohort study

SUBVALUE()Diagnosis of prostate cancer at


National Health and Nutrition

NIH, American Cancer Society, Cohort study

SUBVALUE()40-79 y SUBVALUE()

Stroke, CHD, cancer, valid FFQ


Japan Collaborative

Gov t SUBVALUE()Cohort Study

SUBVALUE()40-59 y SUBVALUE()

MI, angina, stroke, cancer at baseline

Japan Public Health Center

Gov t SUBVALUE()Female dietetic

students 20-23 yrs Netherlands Institute for Dairy Cohort study

SUBVALUE()Residence in England and

Subjects could not identified through


The Boyd Orr cohort

The World Cancer Research Fund, Cohort study

(posthoc) representative Dutch older

not living independently; no

Longitudinal Aging Study Amsterdam

government SUBVALUE()1. RCT (for

supplement part RCT part: Postmenopausal

RCT part: Predicted survival

1993-1998 (after 1-year run-in

1. Women s Health Initiative

NHLBI, DHHS SUBVALUE()Fully lactating

mothers within 1 DM; HTN; parathyroid

academic; NIH SUBVALUE()Cohort study

SUBVALUE()Framingham Offspring 25(OH)D

Prevalent CVD or CKD SUBVALUE()

1996-2000 (originally 1971)

Framingham Offspring Newly diagnosed

adenomatous Conditions predisposing to

Europe Against Cancer, Sandoz Cohort study

SUBVALUE()> 40 yrs old (n=3282) Total

Hx of cancer, stroke which may


CVD-FACTS SUBVALUE()

National Health Research Healthy, 30-54 yo

DBP 80-89 mm Hg Treatment with antihypertensive


SUBVALUE()Residents who moved into the

Pre-existing CRC were excluded Cohort study 1:

HPFS Cohort HPFS: male dentists,

HPFS: men who failed to fill in the

HPFS: 1986 NHS: 1980 SUBVALUE()

HPFS: Health Professionals

HPFS: NCI NHS: NCI SUBVALUE()Case-cohort study

SUBVALUE()Male US health professionals


National Cancer Institute, National -high-normal DBP

(80 to 90 mm Hg) -preexisting cardiovascular or

Trials of Hypertension

NHLBI NIH SUBVALUE()

1986 SUBVALUE()nd SUBVALUE() 1998 SUBVALUE()

RCT SUBVALUE() nd SUBVALUE()

Cohort study SUBVALUE()

Women 55-69 years old who

Baseline history of cancer, including

Iowa Women s Health Study

US NCI SUBVALUE()RCT-post hoc

SUBVALUE()Substudy of the larger Calcium

Substudy of Calcium Intake

Healthway Health Promotion Women between

70 and 90 yr of Current vitamin D consumption,

April 2003 and October 2004

government SUBVALUE()

ExtractorKP/SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()Mc SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()GR SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() HPLC SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() CPBA SUBVALUE() No SUBVALUE() No SUBVALUE()SI SUBVALUE() ELISA SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() No SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL/SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()GR SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE()KP SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE()EB SUBVALUE() No SUBVALUE() nd SUBVALUE()AT SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

RIA SUBVALUE() nd SUBVALUE()TTE SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE()GR SUBVALUE() RIA SUBVALUE() ~5y SUBVALUE() nd SUBVALUE()TTE SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() RIA SUBVALUE() 5 y SUBVALUE()KP/SI SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() HPLC SUBVALUE() 3 wks SUBVALUE()

Background Diet

Background Diet

Background Diet

Background Diet

Background Diet 25(OH)D

determined by y, coefficient of variation in subset Radioimmunoassa

y (Incstar Intra-assay coefficient of

Same day SUBVALUE()

Jan-Feb; March-May; September

HPLC using a diode array

Yes Interassay CV=6.3% and

All seasons (blood were drawn three

See baseline variables

Competitive protein-binding

Interbatch Pearson r for ~3-10 y

SUBVALUE()Within assay CV=5.6% at 21.6

23 (ranged 9-60) nmol/l subjects grouped

by season of Mean Vit D 189 IU/d SUBVALUE()y; interassay CV

10.3% 5-9 years SUBVALUE()

Radioimmunoassay (RIA kit,

Winter (baseline measure only); nd

Vit D+Ca: 25.0 ug/L Placebo: 22.8

25D: RIA (125I) (Hollis 1993)

25D: CV 11.1% interset; 22.0%

~18-20 yr SUBVALUE()

(Late) August through

Using the Nicholas Advantage

25(OH)D 22.0 nmol/L

DiaSorin Liason Chemiluminescent

Y 11.8% SUBVALUE()

Equal % of subjects in both enzyme

immunoassay y; intra and interassay CV:

baseline: Dec to Feb SUBVALUE()

vit D 2.5 g/d SUBVALUE()April and October

SUBVALUE()25(OH)D Nl Ca/Wt maint: 84.1 Competitive

protein binding Mean 11.5 years to diagnosis

25(OH)D: 15-80 ng/ml Not Applicable

SUBVALUE()Not Applicable SUBVALUE()

Not Applicable SUBVALUE()



Immunosorbent assay (Dia-Sorin,

25(OH)D 24.5 ng/mL 25(OH)D -

Competitive Y, intra- and interassay CVs

25(OH)D - 14.0 ng/ml SUBVALUE()86% infant breastfed until 5-6 JHL/TTe

SUBVALUE()Intraset coefficient of variation (CV)

~10 y or 13 y SUBVALUE()

Total Vit D intake: 9.3 g/d, 25(OH)D

25(OH)D measured in

Yes coeff of variation ranged Enzyme

immunoassay Y, coefficient variation=3.2%

26.6 ng/mL SUBVALUE()RIA kit

SUBVALUE()The mean coefficient of

Nd (~7 to ~13 y) (follow-up of the

Vit D intake: 4.7 mcg/d Coeff variation

8.2% for 25(OH)D FFQ for Ca and vit D SUBVALUE()

y; intra and interassay CV

not explicitly reported

UV-B exposure from 2974 RIA for 25-D,

radioreceptor Y; CV = 8.1% for 25-D, 7.9% for

66.4% collected in fall SUBVALUE()

JHL/TTE SUBVALUE()

HPLC and UV absorbance

Inter-assay coefficient of

At least ~9 y (assuming last dx)

Aug-Nov SUBVALUE()

JHL/TTe SUBVALUE()

Radioimmunoassay kit from Nicholas

Y, inter-batch Pearson

11-15y (1988-1992 to ~2003)

inter- and intraassay CV:

February SUBVALUE()

vit D intake Young: 51 IU/d

JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP SUBVALUE()TTE SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE() RIA SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTE SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTE SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()GR SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE() RIA SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()GR SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() None SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()AT SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()AT SUBVALUE()GR SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() nd SUBVALUE()GR SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() RIA SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

VitD 4.4 2.4 g/d SUBVALUE()Not Applicable





Nichols method (Nichols Institute

October to March, 2 successive years

est. <5 g/d intake of vit D Not Applicable





Y, coefficient of variation for

Nd (~6 to ~7 y) (Median f/u of the

April 1999 and March 2000#

Vit D ( g) 2.61 1.28*****





Not Applicable SUBVALUE()DiaSorin Liaison

chemiluminescent dietary vit D 4.5 g/d SUBVALUE()baseline 25(OH)D 71.8 20.3 nmol/L Very little cutaneous

Yes: mean intra-pair coefficients of

Spring or winter: 24.1% of cases

No, Only correlation

Calculated from diet and 25(OH)D: 34.5 mmol/L 25(OH)D

DiaSorin

Competitive protein binding

y; reproducibility at 20 nmol/L 6%

winter, Feb/Mar SUBVALUE()

45% were outside <1 h/d Diasorin Liaison

chemiluminescent 25(OH)D nmol/L <34.4 25.0%, RIA (Incstar)

SUBVALUE()Frozen. Unclear. 10 y SUBVALUE()Not Applicable




Not Applicable SUBVALUE()diet: vit D 40 IU/d SUBVALUE()vit D 35 IU/d (diet?) RIA (DIASORIN)

SUBVALUE()y; interassay and intraassay CV

winter, spring SUBVALUE()

25(OH)D level 42 nmol/L (median, 25(OH)D level at 28-32 wk: 20.1 Not Applicable




Not Applicable SUBVALUE()Total vitamin D (IU/d) included Diasorin

radioimmunoassaCV from quality control samples,

Winter, Jan-Mar: 25% Spring, Apr-

See results SUBVALUE()

y; CV 10.2% SUBVALUE()

winter and summer

25(OH)D in winter: 48.3 nmol/L;

nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() RIA SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() RIA SUBVALUE()SI SUBVALUE() 23 y SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE()AT SUBVALUE()

RIA SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB/SI SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()AT SUBVALUE()MC SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE()GR SUBVALUE() RIA SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE()AT SUBVALUE()KP SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP/SI SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()KP SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()JHL SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() 1-2 y SUBVALUE() nd SUBVALUE() nd SUBVALUE()

RIA SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()SI SUBVALUE() RIA SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() 3 yr SUBVALUE() nd SUBVALUE() nd SUBVALUE()TTe SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()EB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()MC SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()AT SUBVALUE()

RIA SUBVALUE()MB SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE() nd SUBVALUE()

JHL MC SUBVALUE()

VitD intake 0.59 g/d SUBVALUE()Yes: 5% of

samples re-run for Mean (nmol/L) SD in Y, intra-assay and

inter-assay CV, 1 month SUBVALUE()

September and February

Serum 25(OH)D 62.0nmol/L protein-binding

SUBVALUE()Intra-assay CV 5 to 10%

all subjects live in Hawaii

JHL/TTe SUBVALUE()


Intra-assay coefficient of

Inferring 9-14 y (cohort 2) or 12-

VitD intake ( g/d) Men: 6.6 Women: VitD intake 335 IU (men) 340 IU





25(OH)D and 1,25(OH)D via RIA

Coeffs of variation for ALL assays

Serum 25(OH)D = 25 13 nmol/mL. Not Applicable




Not Applicable SUBVALUE()JHL/TTe

SUBVALUE()Intrapair coefficient of

Nd ~6-~11 y(earliest should

Nd (but stratified analyses based on

1,25(OH)2D=31.9 pg/ml

-Intake <700 mg/day of

Diasorin radioimmunoassa

Intra-assay CV=7.6%; Inter-

Mean (SD) = 25 (18-37) nM vit D

25(OH)D competitive

Y, intra-assay coefficient of

At baseline: Tx group mean = Total Vit D intake 306.7 IU/d Not Applicable





electrochemiluminescence

Yes: according to producer, the

Vit D intake (mcg/day)=8.9(6.RIA (Heartland

Assays lab) Yes Overall CV = 4.7% SUBVALUE()

Within 2 hr SUBVALUE()

calendar date of blood draw in 2-

Residential sum exposure at study Y intrabatch and

interbatch The interval between serum

Energy Kcal 2700 Fish 33g Eggs 47 RIA with I125

[25(OH)D] Intraset Coeff of Va: 9.5%

nd~9 to ~12 y inferred)

Vit D intake: 5.3 g/d (4% Not Applicable





53.4 nmol/L SUBVALUE()Not Applicable




Vitamin D dietary intake 172(101)


Y interassay CV <15% JHL/TTe

SUBVALUE()Y, interassay coefficient of dietary vit D 273

IU/d SUBVALUE()RIA (DiaSorin) SUBVALUE()

Yes CoV 8.5% (intraassay); Vit D: 4 (microg/d)

SUBVALUE()





Not Applicable SUBVALUE()JHL/TTe

SUBVALUE()Intrapair coefficient of

~7 to 14 y (based on blood

Winter: 28% Spring/Fall: 21%

455.7 IU/d SUBVALUE()

AT SUBVALUE()No SUBVALUE() nd SUBVALUE()

MC SUBVALUE() No SUBVALUE() nd SUBVALUE() nd SUBVALUE()





Not Applicable SUBVALUE()JHL MC

SUBVALUE()25(OH)D - competitive

September 1998 (end of winter in

68.0 (28.7) nmol/liter RIA (DiaSorin,

Stillwater, MN, Mean 25(OH)D = 44.3 (12.9) nM;

FFQ No nd No ndnd nd nd nd nd ndFFQ nd nd ndnd nd nd nd nd ndFFQ Not Applicable Not Applicable Not ApplicableFFQ No No nd ndFFQ nd Not Applicable Not Applicable Not ApplicableFFQ (Block, 1986) No nd nd ndnd nd nd nd nd ndnd nd No nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd No nd

nd nd nd nd ndnd nd nd Ca balance No nd

Not Applicable Not Applicable ndFFQ nd Not Applicable Not Applicable Not Applicablend nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

(see other article) nd nd ndnd nd nd nd

nd No Not Applicable Not Applicable ndFFQ x 3 d nd No Not Applicable Not Applicable nd

nd No nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd24 hour recall nd nd Not Applicable Not Applicable Not Applicable3-day food records No nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndFFQ nd nd nd nd nd

USDA nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd24HR nd nd ndnd nd nd nd nd ndFFQ Not Applicable Not Applicable ndnd nd nd nd nd ndnd nd nd nd nd nd

nd nd nd ndnd nd nd nd nd ndFFQ & 24 hr recall No Not Applicable Not Applicable ndSFFQ nd nd nd nd nd

nd nd nd nd ndnd nd nd nd nd nd

Background Diet

Background Diet

Background Diet

Background Diet

Background Diet

Background Diet US Department of

Agriculture

USDA, release 10, 1995 + other

Yes Random sample of 127

Spanish food composition

(Previously validated in Spain)General Intake

Estimation System Yes Correlation Ca 0.53nd (need to refer

to NEJM 1999

FFQ, designed for studies of

FFQ (Harvard FFQ by Willet)

USDA Nutrient Database

Yes: reported in Munger et al. Yes Reliability coefficients 0.57-

WHI adaptation of Block FFQ

Yes (not reported here)Short self-

administered Database from the prospective Health Modified block

FFQ

3 day diet record (at baseline and

Food and Nutrient Database 28

62-item National Cancer Institute/

Y (cited two original Block

USDA food composition

Ca intake: 811.8 mg/d

The Norwegian Food Composition

Yes acceptable (reported

28-day diet histories

Food composition table (Ref 2)

Canadian Nutrient File

Semiquantitative food frequency

FFQ USDA nd nd nd7-day food record No Not Applicable Not Applicable Not Applicablenone Not Applicable Not Applicable none Not Applicable ndnd nd nd nd nd ndNot Applicable Not Applicable Not Applicable Not Applicable Not Applicable Not Applicable24HR Nd/n Not Applicable Not Applicable ndnd nd nd nd nd nd

Not Applicable Not Applicable ndnd nd nd nd nd ndFFQ USDA No nd nd ndnd nd nd nd nd nd150 item-FFQ nd No nd nd nd

nd nd nd ndnd nd nd

FFQ nd nd ndnd nd nd nd ndUSDA No nd nd nd

FFQ nd nd ndnd nd nd nd nd nd3-d food records nd No nd nd ndnd nd nd nd nd nd

nd No nd nd ndFFQ nd nd ndFFQ Not Applicable Not Applicable ndFFQ nd nd nd ndFFQ nd nd ndnd nd nd nd nd ndNone Not Applicable Not Applicable nd nd ndFFQ nd nd ndWillet method nd nd nd

nd No nd nd ndnd nd nd nd nd nd

No nd nd ndnd nd nd nd nd nd

nd nd nd nd ndInterview (nd) No nd nd nd

nd nd ndnd nd No nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

USDA nd nd ndnd nd nd

nd nd nd nd nd nd5-day food diaries nd Not Applicable No No

nd nd ndnd nd nd nd nd nd24 h recall nd No nd nd nd

Y (4 day food records from a Other (Food

Processor, version

USDA Handbook #8/supplement,

Diet history Dietary survey

Finnish food composition table

Y (interclass correlation

70-item FFQ slightly modified

Only n=267 assessed; Short FFQ (Rim et al.

1992)USDA and others (Rim et al. 1992)

Correlation of coefficient (energy Conversion of

foods into Y, correlation coefficient for Computerized

questionnaires23 items FFQ (Willett 1985, Standard Tables of

Food Composition Yes, correlation coefficient for

Risk factor questionnaire (no Swedish Food

Administration Yes: by 24HR and correlation Swedish Food

Administration Yes: by 24HR and correlation evaluated previouslySwedish National

Food Y- Pearson correlation

USDA + data from manufacturers

Correlation coefficients (FFQ USDA Nutrient

DatabaseYes, as references to Nurses Health FFQ (88

questions)

3 d dietary record (Tremblay 1983)

Canadian Nutrient File

Food frequency questionnaire Nutrica database

at the Social 113-item Arizona Food Frequency

United States Department of

y assessment of its validity and

68-item semi-quantitative FFQ

y Validated using 4 random 24h FFQ modified from

Questionnaire Diet Analysis System version

Yes. validated using four random

McCance and Widdowson's food 276 item FFQ past

12 modatabase of the Natl Public Health

Yes, intraclass correlation of FFQ

24hr recall nd nd nd ndnd nd nd nd nd nd3-d food records nd No nd nd ndnd nd nd nd nd ndFFQ USDA nd nd nd

No nd nd ndnd nd nd nd nd

nd nd ndUSDA nd nd nd

nd nd ndFFQ (NCI-DHQ) USDA 1994-1996 nd nd ndnd nd nd nd nd ndFFQ nd nd ndSFFQ nd nd nd nd ndnd nd nd nd nd nd

nd nd nd60 item Block FFQ nd No nd nd ndFFQ nd nd nd ndnd nd nd nd nd nd

No nd nd ndnd nd nd nd nd nd

nd nd ndFFQ nd nd ndFFQ (Willet, 1990) nd nd nd

Dutch food tables No nd nd ndFFQ nd nd nd nd

nd nd N/A nd ndnd nd nd nd nd ndFFQ nd nd nd nd nd

nd nd ndnd nd nd nd nd ndnd nd nd Not Applicable Not Applicable ndFFQ No nd nd ndFFQ nd nd ndFFQ nd nd nd nd

No nd nd ndnd nd nd nd

nd nd nd nd nd ndnd nd nd nd nd ndBlock 1998.2 FFQ nd No nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndFFQ nd No nd ndnone Not Applicable Not Applicable nd nd nd

USDA No nd nd ndnd nd nd

FFQ nd nd nd nd ndnd No nd nd nd

Database for Greek food and

Yes, correlation coefficient btw semi-quantitative

FFQHarvard (based on USDA)FFQ (Tsubono et

al, 2003), 44 items Food frequency questionnaire

Data base developed at the

Y, quantitative food frequency 124 item FFQ past

12 moFFQ validated by two 24 h recalls in Self-administered

quantitative FFQFood composition table developed

Y: calibration study comparing Yes (in 1953 participants

Food composition database at the

y Validation study of the dietary

FFQ (modified Block)

Diet Analysis System version

Y, energy-adjusted correlation

Chinese Food Composition

SFFQ (given at baseline to

Dutch food composition table

(1980) 61 item FFQ, (1984, 1986,

USDA Nutrient data base

Y (see other article, Willett et The Chinese Food

Composition Table y Intake levels of major nutrients Harvard University

Food Composition Pearson r between FFQ and 4 1-week FFQ (one-week

recall) Serum Ca was measured at 137 item FFQ

(Deeb, 2007)

Self administered FFQ

Swedish National Food

y Validity evaluated for 129

No specific information, but Japan Food Table v4

No (data from other study Yes Spearman rank correlation Specially

developed Dutch computerized food 7-d household

inventory methodDiet in, data-out program (DIDO

N (but authors state that the FFQ

FFQ 56 foods and coffeeHPFS: FFQ NHS: FFQ

HPFS: USDA and others (REF 33-36)

y (REF 33-36) HPFS: Pearson

24-hr diet recall, FFQ

nd nd ndnd nd nd nd nd

FFQ NUTTAB 90 No No nd nd

Semiquantitative FFQ (by Willet)

USDA Nutrient Database

y For validity and reliability see Semiquantitative

food frequency

ndndndndnd

nd910 mgnd500 mg/dayCa 721 mg/dnd

ndndndndnd

nd

ndndndnd

ndnd

ndndndndnd

ndnd

nd776 mg/dnd876mgnd

Background Diet

Median Ca intake (mg/d) -

Dietary calcium 857 mg/dVit D+Ca: 1078 mg/day Placebo: Ca intake mg/d (SEM) = 586 (137)Total Ca=1118.3 mg/d

See previous table Total Ca 1150

the % of subjects in the placebo arm dietary calcium: 670 mg/d

Total Ca 723.5 mg/d

Total Ca intake: 1049.2 mg/day

907 mg/d (M); 637 mg/d (F)

mg/1000kcal Cancer: 316.7 No

981 435 mg/dNot ApplicablendndNot ApplicableCa: 575 mg/dnd1414 mg/dnd

nd

ndCa=947.0 mg/d

ndnd

nd

ndndnd

nd

nd

ndnd

ndndnd

ndnd

nd

Calcium 933.4 51.8 (SE) mg/d

Ca=1286 mg/d (energy-adjusted

Calcium (mg) 1014.15 Evaluated were calcium, dairy

Daily total calcium, mg CaD dietary intake calcium: 819 mg/d

Mean dairy servings/wk = 6 Ca=809-1665 mg/dCa=809-1665 mg/d

Low Ca diet run-in882 mg/d (median)Calcium dietary intake: Dairy dietary calcium: 957 mg/d

Ca+D: 708.0 (119) mg/d Placebo:

Total Ca intake mg/d <600 19.7%,

diet: calcium 500 mg/dcalcium 429 mg/d (diet?)

68-item food frequency

dietary calcium=1513

dietary calcium pre-intervention:

Ca 679.7 mg/d

nd

ndnd984.5mg/d

Nd 6547130

ndndndnd

ndSee results

ndCa=1.3 g/dndnd

ndndndCa 547.82 mg/dnd

nd

ndnonendNot Applicable939 mg/dCa 970mg/d

Serum Ca (mmol/L) SD = Ca intake 908.2 mg/d

Ca Quintile 1; 510mg Quintile 3: calcium (dietary & supplement): Ca intake (mg/d) Men: 455.7 Ca 960mg (men) 1066mg (women)calcium from non-dairy food (346-7% took calcium supplements Total calcium intake (10th to

Dietary calcium 857 mg/d

25% used calcium supplements

Total Ca intake 773.7 mg/d

Men 929 415mg/d Women Ca intake (mg/day)=940(39Median (IQR) total calcium intake

Mean total Ca intake at 4 year Calcium 730(347) mg/d

Ca (supplements+diecalcium intake: 1125 mg/d

Calcium: 928 (mg/d) by FFQ

1010 mg/dCa mg/d < 800.8 (n=56), 800.8-

Mean calcium intake = 1097

Study ID:EF ID Creator Create Date PMID6304:194 admin Aug 18, 2013 Sep 5, 2014 185059676305:194 admin Aug 18, 2013 Sep 5, 2014 110758746306:194 admin Aug 18, 2013 Sep 5, 2014 126632776307:194 admin Aug 18, 2013 Sep 5, 2014 78928826308:194 admin Aug 18, 2013 Sep 5, 2014 162804276309:194 admin Aug 18, 2013 Sep 5, 2014 182086366311:194 admin Aug 18, 2013 Sep 5, 2014 13303606312:194 admin Aug 18, 2013 Sep 5, 2014 86211986313:194 admin Aug 18, 2013 Sep 5, 2014 97435116314:194 admin Aug 18, 2013 Sep 5, 2014 157673346315:194 admin Aug 18, 2013 Sep 5, 2014 161034506316:194 admin Aug 18, 2013 Sep 5, 2014 179650376317:194 admin Aug 18, 2013 Sep 5, 2014 186895596318:194 admin Aug 18, 2013 Sep 5, 2014 175359856319:194 admin Aug 18, 2013 Sep 5, 2014 181983946320:194 admin Aug 18, 2013 Sep 5, 2014 172438666321:194 admin Aug 18, 2013 Sep 5, 2014 188427716322:194 admin Aug 18, 2013 Sep 5, 2014 83334126323:194 admin Aug 18, 2013 Sep 5, 2014 99219606325:194 admin Aug 18, 2013 Sep 5, 2014 76128036326:194 admin Aug 18, 2013 Sep 5, 2014 187553196327:194 admin Aug 18, 2013 Sep 5, 2014 167979036328:194 admin Aug 18, 2013 Sep 5, 2014 176564206329:194 admin Aug 18, 2013 Sep 5, 2014 175025306330:194 admin Aug 18, 2013 Sep 5, 2014 115666566331:194 admin Aug 18, 2013 Sep 5, 2014 190016016333:194 admin Aug 18, 2013 Sep 5, 2014 162804476334:194 admin Aug 18, 2013 Sep 5, 2014 152130386335:194 admin Aug 18, 2013 Sep 5, 2014 82200926336:194 admin Aug 18, 2013 Sep 5, 2014 86824536337:194 admin Aug 18, 2013 Sep 5, 2014 88906616338:194 admin Aug 18, 2013 Sep 5, 2014 171895526339:194 admin Aug 18, 2013 Sep 5, 2014 162782626340:194 admin Aug 18, 2013 Sep 5, 2014 80781156341:194 admin Aug 18, 2013 Sep 5, 2014 153424526342:194 admin Aug 18, 2013 Sep 5, 2014 156684856343:194 admin Aug 18, 2013 Nov 6, 2013 19376626344:194 admin Aug 18, 2013 Sep 5, 2014 173720316345:194 admin Aug 18, 2013 Sep 5, 2014 188386236346:194 admin Aug 18, 2013 Sep 5, 2014 179715266347:194 admin Aug 18, 2013 Sep 5, 2014 183814726348:194 admin Aug 18, 2013 Sep 5, 2014 90612756349:194 admin Aug 18, 2013 Sep 5, 2014 173110576350:194 admin Aug 18, 2013 Sep 5, 2014 88502736351:194 admin Aug 18, 2013 Sep 5, 2014 28573646352:194 admin Aug 18, 2013 Sep 5, 2014 25729006353:194 admin Aug 18, 2013 Sep 5, 2014 7493659

Last Updated

6356:194 admin Aug 18, 2013 Sep 5, 2014 146522386357:194 admin Aug 18, 2013 Sep 5, 2014 172279966358:194 admin Aug 18, 2013 Sep 5, 2014 105113296359:194 admin Aug 18, 2013 Sep 5, 2014 156712226360:194 admin Aug 18, 2013 Sep 5, 2014 162865196361:194 admin Aug 18, 2013 Sep 5, 2014 145539576362:194 admin Aug 18, 2013 Sep 5, 2014 124993436363:194 admin Aug 18, 2013 Sep 5, 2014 94050296364:194 admin Aug 18, 2013 Sep 5, 2014 39462956367:194 admin Aug 18, 2013 Nov 6, 2013 104714226368:194 admin Aug 18, 2013 Nov 6, 2013 104714226369:194 admin Aug 18, 2013 Sep 5, 2014 152258336370:194 admin Aug 18, 2013 Sep 5, 2014 116417506371:194 admin Aug 18, 2013 Sep 5, 2014 174421306372:194 admin Aug 18, 2013 Sep 5, 2014 82014446373:194 admin Aug 18, 2013 Sep 5, 2014 175528806374:194 admin Aug 18, 2013 Sep 5, 2014 82055386375:194 admin Aug 18, 2013 Sep 5, 2014 93438376376:194 admin Aug 18, 2013 Sep 5, 2014 86107046377:194 admin Aug 18, 2013 Sep 5, 2014 158805326378:194 admin Aug 18, 2013 Sep 5, 2014 175361916379:194 admin Aug 18, 2013 Sep 5, 2014 171064376380:194 admin Aug 18, 2013 Sep 5, 2014 183980336381:194 admin Aug 18, 2013 Sep 5, 2014 192211906382:194 admin Aug 18, 2013 Sep 5, 2014 153541506383:194 admin Aug 18, 2013 Sep 5, 2014 175566976384:194 admin Aug 18, 2013 Sep 5, 2014 184333056385:194 admin Aug 18, 2013 Sep 5, 2014 165229156386:194 admin Aug 18, 2013 Sep 5, 2014 165229156387:194 admin Aug 18, 2013 Sep 5, 2014 183322896388:194 admin Aug 18, 2013 Sep 5, 2014 190565696389:194 admin Aug 18, 2013 Sep 5, 2014 173886676390:194 admin Aug 18, 2013 Sep 5, 2014 85579656391:194 admin Aug 18, 2013 Sep 5, 2014 158002686392:194 admin Aug 18, 2013 Sep 5, 2014 175332086393:194 admin Aug 18, 2013 Sep 5, 2014 164000446394:194 admin Aug 18, 2013 Sep 5, 2014 174739116395:194 admin Aug 18, 2013 Sep 5, 2014 172091776396:194 admin Aug 18, 2013 Sep 5, 2014 37555176397:194 admin Aug 18, 2013 Sep 5, 2014 188246626398:194 admin Aug 18, 2013 Sep 5, 2014 159554676399:194 admin Aug 18, 2013 Sep 5, 2014 120201026401:194 admin Aug 18, 2013 Sep 5, 2014 36232606402:194 admin Aug 18, 2013 Sep 5, 2014 32436096403:194 admin Aug 18, 2013 Sep 5, 2014 163915876404:194 admin Aug 18, 2013 Sep 5, 2014 67930586405:194 admin Aug 18, 2013 Sep 5, 2014 127087196406:194 admin Aug 18, 2013 Sep 5, 2014 16365007

6407:194 admin Aug 18, 2013 Sep 5, 2014 186950766408:194 admin Aug 18, 2013 Sep 5, 2014 188278116409:194 admin Aug 18, 2013 Sep 5, 2014 171064376410:194 admin Aug 18, 2013 Sep 5, 2014 163526846411:194 admin Aug 18, 2013 Sep 5, 2014 112624666412:194 admin Aug 18, 2013 Sep 5, 2014 171818906413:194 admin Aug 18, 2013 Sep 5, 2014 191257566414:194 admin Aug 18, 2013 Sep 5, 2014 191582266415:194 admin Aug 18, 2013 Sep 5, 2014 97941756416:194 admin Aug 18, 2013 Sep 5, 2014 173796166417:194 admin Aug 18, 2013 Sep 5, 2014 175219216418:194 admin Aug 18, 2013 Sep 5, 2014 176222446419:194 admin Aug 18, 2013 Sep 5, 2014 172153806420:194 admin Aug 18, 2013 Sep 5, 2014 180000206421:194 admin Aug 18, 2013 Sep 5, 2014 179252836422:194 admin Aug 18, 2013 Sep 5, 2014 192377246423:194 admin Aug 18, 2013 Sep 5, 2014 112975966424:194 admin Aug 18, 2013 Sep 5, 2014 105306086425:194 admin Aug 18, 2013 Sep 5, 2014 110457886428:194 admin Aug 18, 2013 Sep 5, 2014 158271036429:194 admin Aug 18, 2013 Sep 5, 2014 128693976430:194 admin Aug 18, 2013 Sep 5, 2014 173153196431:194 admin Aug 18, 2013 Sep 5, 2014 92364166432:194 admin Aug 18, 2013 Sep 5, 2014 155315006433:194 admin Aug 18, 2013 Sep 5, 2014 103621256434:194 admin Aug 18, 2013 Sep 5, 2014 74981006435:194 admin Aug 18, 2013 Sep 5, 2014 122088956436:194 admin Aug 18, 2013 Sep 5, 2014 170197166437:194 admin Aug 18, 2013 Sep 5, 2014 169850316438:194 admin Aug 18, 2013 Sep 5, 2014 84781446439:194 admin Aug 18, 2013 Sep 5, 2014 190569006441:194 admin Aug 18, 2013 Sep 5, 2014 192088426442:194 admin Aug 18, 2013 Sep 5, 2014 170470876443:194 admin Aug 18, 2013 Sep 5, 2014 92424786444:194 admin Aug 18, 2013 Nov 6, 2013 124671336445:194 admin Aug 18, 2013 Sep 5, 2014 33073076446:194 admin Aug 18, 2013 Sep 5, 2014 126099406447:194 admin Aug 18, 2013 Sep 5, 2014 158834416450:194 admin Aug 18, 2013 Sep 5, 2014 163394766451:194 admin Aug 18, 2013 Sep 5, 2014 186358556452:194 admin Aug 18, 2013 Sep 5, 2014 37888356453:194 admin Aug 18, 2013 Sep 5, 2014 180655926455:194 admin Aug 18, 2013 Sep 5, 2014 169601776456:194 admin Aug 18, 2013 Sep 5, 2014 164816366457:194 admin Aug 18, 2013 Sep 5, 2014 176615656458:194 admin Aug 18, 2013 Nov 6, 2013 182590076459:194 admin Aug 18, 2013 Sep 5, 2014 181803956460:194 admin Aug 18, 2013 Sep 5, 2014 8675093

6461:194 admin Aug 18, 2013 Sep 5, 2014 189889096462:194 admin Aug 18, 2013 Sep 5, 2014 90225616463:194 admin Aug 18, 2013 Sep 5, 2014 36203146464:194 admin Aug 18, 2013 Sep 5, 2014 119043166465:194 admin Aug 18, 2013 Sep 5, 2014 176238016466:194 admin Aug 18, 2013 Sep 5, 2014 77958376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 18410225

Alt ID(s) Title Year Author2008200020031995200520081992199619982005200520082008200720082007200819931999199520082006200720072001200820052004-- Not Found ---- Not Found --1996200620061994200420051991 Ford ES., Cooper RS.2007200820072008199620081996198519891995
















































products on plasma uric Ghadirian P., Shatenstein B., Verdy M., Hamet P.

200320071999200520052003200319971986199919992004200120071994200819941997199620052007200620082009200420072008200620062008200920071995 Lijnen P., Petrov V.200520072006200720071986200820052002198719882006198120032005

Vitamin D, calcium supplementation, and

Grau MV., Baron JA., Sandler RS., Haile RW., Prolonged effect of















































vitamin D intake and McCullough ML., Rodriguez C., Diver WR., Feigelson


25-hydroxyvitamin D levels and the risk of

Melamed ML., Michos ED., Post W., Astor B.Dietary calcium and















































controlled calcium Weisgerber UM., Boeing H., Owen RW., Waldherr

200819971987200220071995199820082008

Is ischemic stroke risk related to folate status or

Weng LC., Yeh WT., Bai CH., Chen HJ., Chuang SY., Efficacy of









Calcium Dairy diet0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 1 0 0 0 0 0

Ca intake - Quintile

Vit D intake -


maternal vit D at

Ca (mg/1000

1 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

zero dose0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca (mg/1000

Ca (mg/1000

1,25(OH)D - Tertile



Cholecalciferol 400

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

2-Q2 2-Q10 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Training + Ca



25(OH)D - Quintile


0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Quartile 1: 1,25-D

Ca (mg/1000

Calcium carbonicu

Quartile 1:

Vit D intake -

Cholecalciferol

Quartile 4: highest

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

<32 5000 IU0 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1,25(OH)D - Tertile

Quartile 4: 1,25-D

Quintile 3: 23.5-


Serum 25(OH)D -

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

10000 IU0 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Severe deficiency

Quintile 2: 18.3-

Ca + placebo

Dietary Ca

Ca intake - Quartile

Quintile 3: 51.4-

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Control0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

100 mg of elemental


Baseline 25(OH)D -

Quintile 3: 33.5-

Vit D3 + Ca

Calcium placebo

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

>= 30.0 4-Q10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0


Quartile 4: >75

Urinary Ca 236-


Calcium, both

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

4-Q2 4-Q3 4-Q40 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

High 25(OH)D,


Ca 500 mg/d + vit

Ca Intake - Quartile

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Baseline 25(OH)D -





Vit D + Ca + placebo


0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 1 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Low 25(OH)D,

Quartile 3 + Quartile

1,25(OH)2D -

Baseline 25(OH)D -

1,25(OH)2D -

No training +

1,25(OH)2D -

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 01 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1,25(OH)2D -

1,25(OH)2D -

25(OH)D - Quintile

Quartile 1: 25-D

Quartile 2: 1,25-D

Calcium intake -

Medium dairy

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 0

Vit D3 Vit D20 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Calcium carbonate

Quintile 1: <28.2

1,25(OH)D - Tertile

Quartile 1: lowest

No chemopre

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

< 30.00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

No chemopre

Ca suppleme

Baseline 25(OH)D -


Baseline 25(OH)D -

1,25(OH)2D - Tertile

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

mom 6400

Baseline 25(OH)D -

1,25 OH-D,


Ca intake - Tertile 2



0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1000 IU0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0


No Calcium

Quintile 2: 28.2-

unsupplemented

25(OH)D - Tertile 2

25(OH)D - Tertile 1

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 01 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Vit D0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca intake, per 1

Urinary Ca 169.1-

25(OH)D - Tertile 3

Calcium intake -

1,25(OH)D -

1,25(OH)D -

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 1 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

6-Q4 6-Q5 6-Q2 6-Q30 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1,25(OH)D -

1,25(OH)D -


0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

200 IU 6-Q6 100 IU0 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

25(OH)D >= 15


Baseline 25(OH)D -

Quintile 5: 71.8-

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

6-Q10 0 0 0 0 0 00 0 0 0 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 0

Dairy free diet


Ca + Placebo

25(OH)D - Group 1:

Training + + Ca + Vit

Quartile 2:

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 1 0 0 0

Referent Tertile 2 Tertile 1 Tertile 30 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

>41.1 and <51.1

1,25(OH)D - Tertile

Quartile 2: 25-D

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

High dairy0 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 10 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 0

Urinary Ca 20.3-

Baseline 1,25(OH)2

25(OH)D - Quintile 1

Vit D intake -

Quintile 2: 42.5-

Baseline 1,25(OH)2

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 01 1 1 0 1 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 1 10 0 0 0 0 0 0

25(OH)2D - Quintile


25(OH)2D - Quintile

Baseline 1,25(OH)2

25(OH)2D - Quintile



0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Usual diet Quintile 5 Ca + Vit D0 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0


High dairy (high Ca)

>51.1 and <65.5

25(OH)D - Group 2:

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 1 0 0 0 00 0 0 0 0 1 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Quintile 2 Quintile 1 Quintile 4 Quintile 30 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca intake Categorie

Ca intake (diet +

1.2 million IU

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 01 0 0 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Cases0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Vit D2 supplmen

Ca intake -

Placebo, both



1,25(OH)2D -

0 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1,25(OH)2D -

Quintile 1: <18.3

1,25(OH)2D -

Quartile 2: 30-50

Vit D 1000 IU/d

Quartile 4: 25-D

No chemopre

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca 500 mg/d + vit

25(OH)D <15

Quintile 4: 39-

25 OH-D, quartile



1,25(OH)2D -

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Controls0 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0


25(OH)2D - Quintile

25(OH)2D - Quintile

25(OH)D - Quartile 4


Quartile 3:

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

>65.5 Quartile 3 Quartile 4 Quartile 1 Quartile 20 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca 500 mg/d +

Ca + 10000 D2

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 1 1 1 0 00 1 1 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Dairy product

Vit D intake -

High 25(OH)D,

Quartile 3: 1,25-D

Urinary Ca 125.0-



0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 10 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

3-Q3 calciferol0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0


Quartile 1:<30

Low 25(OH)D,

25(OH)D - Quintile

Quintile 5: >=

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

3-Q1 3-Q2 High Vit D0 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Total daily

Caclium (patients

Quartile cut off

25(OH)D - Quintile

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 1 0 1 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 0

Dairy Ca intake -

Dairy Ca intake -

Ca enriched

Dairy Ca intake -

25(OH)D - Quintile

Dairy Ca intake -

25(OH)D - Group 2

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 01 1 0 1 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Total0 1 0 0 0 0 10 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 1 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 1 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 1 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 01 1 0 0 0 0 00 1 0 0 0 0 0

25(OH)D - Group 1

Quintile 5: >=

Caclium (patients


Vit D3 10 ug/d

Quintile 4: 60.6-

0 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 1 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 0

0 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 0

Vit D + Ca0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca carbonate

Quartile 3: >50-75


Quartile 3: 25-D


Vit D3 20 ug/d

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0

Deficiency0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1,25(OH)D - Tertile

infant placebo


Vit D 200,000

Ca + 5000 D2

Quintile 4: 28.3-

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Dairy Ca0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0



1,25(OH)D - Tertile

>32 and <41.1

Control (low Ca)


0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

400 IU infant 3000 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Vit D2 + Ca

Quartile 4: highest

Calcium intake -

Cholecalciferol 1200

Quintile 2-5

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 1 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Baseline dietary Ca

Baseline dietary Ca

Baseline dietary Ca

No training +

25(OH)D, published


Vit D intake -

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Lactoval mom 4000 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Ca suppleme

Baseline 25(OH)D -

Calcium carbonicu

Dairy group


0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Placebo Low Vit D0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

>= 28 nmol/L


Quartile 1: lowest



0 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 0

0 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 0


Last Updated


6414:194 admin Aug 18, 2013 Sep 5, 2014 191582266423:194 admin Aug 18, 2013 Sep 5, 2014 112975966423:194 admin Aug 18, 2013 Sep 5, 2014 112975966428:194 admin Aug 18, 2013 Sep 5, 2014 158271036428:194 admin Aug 18, 2013 Sep 5, 2014 158271036434:194 admin Aug 18, 2013 Sep 5, 2014 74981006434:194 admin Aug 18, 2013 Sep 5, 2014 74981006439:194 admin Aug 18, 2013 Sep 5, 2014 190569006439:194 admin Aug 18, 2013 Sep 5, 2014 190569006439:194 admin Aug 18, 2013 Sep 5, 2014 190569006445:194 admin Aug 18, 2013 Sep 5, 2014 33073076445:194 admin Aug 18, 2013 Sep 5, 2014 33073076446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406452:194 admin Aug 18, 2013 Sep 5, 2014 37888356452:194 admin Aug 18, 2013 Sep 5, 2014 37888356456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366460:194 admin Aug 18, 2013 Sep 5, 2014 86750936460:194 admin Aug 18, 2013 Sep 5, 2014 86750936462:194 admin Aug 18, 2013 Sep 5, 2014 90225616462:194 admin Aug 18, 2013 Sep 5, 2014 90225616466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 18410225


The influence of menopause and hormonal

Aloia JF., Vaswani A., Russo L., Sheehan M., The influence of

menopause and hormonal Aloia JF., Vaswani A., Russo L., Sheehan M., Effect of vitamin D

supplementation on bone Andersen R., Mølgaard C., Skovgaard LT., Brot C., Effect of vitamin D


supplementation on bone Andersen R., Mølgaard C., Skovgaard LT., Brot C., Risk of prostate cancer in

a randomized clinical trial Baron JA., Beach M., Wallace K., Grau MV., Vitamin D

supplementation has Björkman M., Sorva A., Risteli J., Tilvis R.Vitamin D



hydroxy vitamin D Blum M., Dallal GE., Dawson-Hughes B.Body size and serum 25

hydroxy vitamin D Blum M., Dallal GE., Dawson-Hughes B.Vascular events in healthy

older women receiving Bolland MJ., Barber PA., Doughty RN., Mason B., Vascular events in healthy


controlled trial of vitamin Bolton-Smith C., McMurdo ME., Paterson CR., Mole Two-year randomized


supplementation in Bortolotti M., Rudelle S., Schneiter P., Vidal H., Dairy calcium

supplementation in Bortolotti M., Rudelle S., Schneiter P., Vidal H., Calcium, vitamin D

supplementation, and Brunner RL., Cochrane B., Jackson RD., Larson J., Calcium, vitamin D


supplementation and Bunout D., Barrera G., Leiva L., Gattas V., de la Effects of vitamin D


inpatients falling? A Burleigh E., McColl J., Potter J.Does vitamin D stop


supplementation and the Caan B., Neuhouser M., Aragaki A., Lewis CB., Calcium plus vitamin D

supplementation and the Caan B., Neuhouser M., Aragaki A., Lewis CB., Calcium plus vitamin D


product, and vitamin D Cheng S., Lyytikäinen A., Kröger H., Lamberg-Allardt Effects of calcium, dairy




intake influence calcium Cifuentes M., Riedt CS., Brolin RE., Field MP., Weight loss and calcium

intake influence calcium Cifuentes M., Riedt CS., Brolin RE., Field MP., Calcium chemoprevention

in colorectal cancer.Duris I., Hruby D., Pekarkova B., Huorka M., Calcium chemoprevention

in colorectal cancer.Duris I., Hruby D., Pekarkova B., Huorka M., Effect of 1-year dairy

product intervention on fat Eagan MS., Lyle RM., Gunther CW., Peacock M., Effect of 1-year dairy



replacement on El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., Effect of vitamin D


replacement on El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., The influence of dairy

products on plasma uric Ghadirian P., Shatenstein B., Verdy M., Hamet P.The influence of dairy

products on plasma uric Ghadirian P., Shatenstein B., Verdy M., Hamet P.Prolonged effect of

calcium supplementation Grau MV., Baron JA., Sandler RS., Wallace K., Prolonged effect of


D responses of younger Harris SS., Dawson-Hughes B., Perrone GA.Plasma 25-hydroxyvitamin

D responses of younger Harris SS., Dawson-Hughes B., Perrone GA.The impact of calcium and

dairy product consumption Harvey-Berino J., Gold BC., Lauber R., Starinski A.

200520032003200320032003200319971997200820082008200920042004200720072007200820081995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.200620062007200720072007198619861986200820081987198719881988200620062006198119812006 Moschonis G., Manios Y.2006 Moschonis G., Manios Y.2006 Moschonis G., Manios Y.200920092009

The impact of calcium and dairy product consumption

Harvey-Berino J., Gold BC., Lauber R., Starinski A.Gestational calcium

supplementation and Hatton DC., Harrison-Hohner J., Coste S., Reller Gestational calcium


hydroxycholecalciferol Heaney RP., Davies KM., Chen TC., Holick MF., Human serum 25-




supplementation may Heikkinen AM., Tuppurainen MT., Long-term vitamin D3

supplementation may Heikkinen AM., Tuppurainen MT., Calcium intake and the

outcome of short-term Kabrnová-Hlavatá K., Hainer V., Gojová M., Calcium intake and the


outcome of short-term Kabrnová-Hlavatá K., Hainer V., Gojová M., Calcium plus vitamin D


diet gain weight at the Lappe JM., Rafferty KA., Davies KM., Lypaczewski Girls on a high-calcium


supplementation reduces Lappe JM., Travers-Gustafson D., Davies KM., Vitamin D and calcium



supplementation Lappe J., Cullen D., Haynatzki G., Recker R., Calcium and vitamin d

supplementation Lappe J., Cullen D., Haynatzki G., Recker R., Dietary calcium, blood

pressure and cell Dietary calcium, blood pressure and cell Calcium supplementation for 1 y does not reduce

Lorenzen JK., Mølgaard C., Michaelsen KF., Astrup A.Calcium supplementation


among older people living Lyons RA., Johansen A., Brophy S., Newcombe RG., Preventing fractures


calcium + vitamin D Major GC., Alarie F., Doré J., Phouttama S., Tremblay Supplementation with


supplementation in Mallet E., Gügi B., Brunelle P., Hénocq A., Basuyau JP., Vitamin D



vitamin D supplementation Margolis KL., Ray RM., Van Horn L., Manson JE., Allison Effect of calcium and


vitamin D supplementation Marya RK., Rathee S., Manrow M.Effect of calcium and


supplementation during Marya RK., Rathee S., Dua V., Sangwan K.Effect of vitamin D


to rapidly increase 25OHD Mastaglia SR., Mautalen CA., Parisi MS., Oliveri B.Vitamin D2 dose required



enhance weight gain and Maxwell JD., Ang L., Brooke OG., Brown IR.Vitamin D supplements

enhance weight gain and Maxwell JD., Ang L., Brooke OG., Brown IR.Skeletal site-dependent

response of bone mineral Skeletal site-dependent response of bone mineral Skeletal site-dependent response of bone mineral A double-blind, randomized, placebo-

Nagpal J., Pande JN., Bhartia A.A double-blind,

randomized, placebo-Nagpal J., Pande JN., Bhartia A.Supplements of 20

microg/d cholecalciferol Nelson ML., Blum JM., Hollis BW., Rosen C.,

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Supplements of 20 microg/d cholecalciferol

Nelson ML., Blum JM., Hollis BW., Rosen C., Effects of a short-term

vitamin D(3) and calcium Pfeifer M., Begerow B., Minne HW., Nachtigall D., Effects of a short-term

vitamin D(3) and calcium Pfeifer M., Begerow B., Minne HW., Nachtigall D., Effects of calcium

supplementation on body Reid IR., Horne A., Mason B., Ames R., Bava U., Effects of calcium

supplementation on body Reid IR., Horne A., Mason B., Ames R., Bava U., Effect of winter oral

vitamin D3 Scragg R., Khaw KT., Murphy S.Effect of winter oral

vitamin D3 Scragg R., Khaw KT., Murphy S.Supplementation with

cholecalciferol does not Sneve M., Figenschau Y., Jorde R.Supplementation with


cholecalciferol does not Sneve M., Figenschau Y., Jorde R.Dietary calcium intake and

blood pressure in Thomsen K., Nilas L., Christiansen C.Dietary calcium intake and


vitamin D3 Trivedi DP., Doll R., Khaw KT.Effect of four monthly oral

vitamin D3 Trivedi DP., Doll R., Khaw KT.Oral calcium and blood

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supplementation and the Wactawski-Wende J., Kotchen JM., Anderson GL., Calcium plus vitamin D

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controlled calcium Weisgerber UM., Boeing H., Owen RW., Waldherr Effect of longterm placebo

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nonpharmacologic Whelton PK., Kumanyika SK., Cook NR., Cutler JA., Efficacy of

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vitamin D supplementation Zhu K., Devine A., Dick IM., Wilson SG., Prince RL.Effects of calcium and



trial of the effects of Zhu K., Bruce D., Austin N., Devine A., Ebeling PR., Randomized controlled


Arm Source DoseCa supplement nd about type 1700 mg Ca 2.9 +/- 1.1 yrs. ndCalcium placebo nd nd nd ndVit D3 10 ug/d 10 ug/d 1 yr DailyVit D3 20 ug/d nd 20 ug/d 1 yr DailyPlacebo 0 1 yr Daily

nd nd6 months nd6 months nd

Placebo nd nd nd ndVit D + Ca nd 3 y ndPlacebo nd Placebo 3 y ndCalcium 1 g (elemental) 5 yearsPlacebo nd nd nd nd

2 yearsPlacebo nd nd nd ndCalcium 800 mg/d 5 wksPlacebo - 5 wksPlacebo nd nd nd ndVit D + Ca Average 7.1 yrs two times a dayCalcium nd 800mg of Ca 9 months one time/dayVit D + Ca nd 9 months one time/dayVit D + Ca Once dailyCalcium calcium carbonate Once dailyVit D + Ca 1000 mg 400 IU 7 yearsPlacebo nd nd 7 years 2x/dayVit D3 + Ca GlaxoSmith Kline 7 yearsVit D + Ca 24 moCa + Placebo ndDairy product nd nd ndPlacebo nd ndCalcium 6 weeksPlacebo 6 weeks

2 g ndnd nd

High dairy Foods from dairy 1y ndMedium dairy Foods from dairy 1y ndControl nd 1y ndLow Vit D 200IU/d 1yHigh Vit D 2000IU/d 1yPlacebo Oily solution nd 1yDairy diet Regular food 4 wk 3 mealsDairy free diet nd nd ndCalcium 4y 1 time/dayPlacebo nd nd nd ndPlacebo nd nd nd ndVit D2 supplment 1800 IU/d 3 wk qAM

12 months nd

Arm Description

Intervention Duration

Intervention

Scanphrm A/S (Birkerod,

Cellulosum microcristalliumCa carbonate

supplementCaCO3 3g (= elemental Ca

Mean 44 mo (Compliance >/= Cholecalciferol

400 IU/dayCholecalciferol (Vigantol, Merck

Vitamin D 400 IU/day (group II)Cholecalciferol

1200 IU/dayCholecalciferol (Vigantol, Merck

Vitamin D 1200 IU/day (group III)

vit D3 700 IU + Ca 500 mg/d

Calcium citrate (Citracal)

2 x 200 mg before breakfast; 3 x 200

100 mg of elemental calcium

A chewable tablet form contains

100 mg of elemental calcium

2 tablets per day with breakfast

Dairy Ca supplement

Sachets were taken 2 times a Made of

maltodextrin and Sachets were taken 2 times a

500mg calcium carbonate +

1000mg calcium carbonate +

800mg of Ca + 400 IU of vitDcholecalciferol

+calcium 800iu cholecalciferol

The intervention was continued 1200mg calcium

carbonateContinued until time of patient Ca carbonate

Cholecalciferol500 mg/200 IU 2x/day

400 IU vit D 1000 mg Ca

200 IU vit D x twice daily 500 Tums or Kalcipos

(calcium); 1000 mg calcium carbonate + 200

one tab in am; one tab in pm; drops Tums or Kalcipos

(calcium)1000 mg calcium carbonate + vit D

one tab in am; one tab in pm; drops 1000 mg calcium

equivalentcalcium placebo + vit D placebo

one tab in am; one tab in pm; drops Supplement of

calcium citrate, 1.2 g/d in high calcium group

2 Ca tablets in the morning, 3 in the Supplement of

calcium citrate, 0.4 g/d in normal calcium group

2 tablets in the morning, 3 in the Caclium (patients

with polyps)Calcium carbonicum

Mean: 3.1 yr range 1-6 yr Caclium (patients

with CRC)Calcium carbonicum

~50 mo (based on Kaplan Meier 1300-1400mg

Ca/day from dairy1000-1100mg Ca/day from dairyMaintain current dietary Diluted Vigantol

oil, Merck KGaA, Weekly, usually taken on the Vigantol oil, Merck

KGaA, Darmstadt, Weekly, usually taken on the Weekly, usually taken on the Achieved 1242

mg/d (30 g dairy Achieved 377 mg/dayCa

supplementation1200mg of elemental calcium

Drisdol (Sanofi Winthrop, NY)High dairy (high

Ca)3-4 dairy servings/d (milk,

Goal of 1200 to 1400 mg/d Ca

Control (low Ca) 12 months ndPlacebo nd nd nd nd

Ca carbonate 2 gzero dose nd zero dose ~20 wk nd1000 IU 25 g (1000 IU) ~20 wk 1 tab5000 IU Tishcon, NY 125 g (5000 IU) ~20 wk 1 tab10000 IU Tishcon, NY 250 g (10,000 IU) ~20 wk 2 tabsVit D3 + Ca 30 mo ndCalcium 30 mo ndPlacebo Food/tablets 3 wks

3 wksLactoval 3 wksCa + Vit D nd nd nd ndCa enriched diet 1500 mg/d 24 mo ndUsual diet nd nd nd ndPlacebo nd placebo 4 y(?) ndCalcium nd 4 y(?) ndCa + Vit D nd 4 y(?) ndCa + Vit D nd 8 weeksPlacebo nd nd nd ndCa supplement Ca gluconate 2 g 16 wk 1 g 2x/dayPlacebo nd nd nd ndCalcium calcium carbonate 500 mg 1 yPlacebo nd nd nd ndVit D 822IU/d 3 yearsPlacebo nd nd 3 years Every 4 monthsPlacebo nd nd nd ndVit D + Ca 15 wk 1 capsule 2x/dunsupplemented nd nd nd ndVit D 1000 IU/d nd 1000 IU nd

nd nd ndPlacebo nd nd nd ndVit D + Ca 7y 2 times/dVit D + Ca nd 16-20 wk ndPlacebo nd nd nd nd1.2 million IU vit D nd ndPlacebo nd nd nd nd

calcium carbonate 3 mo 1 tablet qd3 mo3 mo

calciferol nd 1000 IU/d 3rd trimester only ndPlacebo nd nd nd ndControl Not Applicable 12 mo Not ApplicableCa supplement 600 mg 12 mo ndDairy group 12 moVit D 6 wkPlacebo - 6 wkVit D3 Vit D3 supplement Vit D3 20 g/d 6 mo One time/day

One dairy serving/d

Goal of 400-500 mg/d Ca

Ca supplement (prenatal)

~20-30 weeks (during pregnancy

2x500 mg capsules 2x/day

Douglas Laboratory,

D-Calsor, Orion Corporation,

300 IU Vit D3/day, 500 mg/day D-Calsor, Orion

Corporation, 500 mg/day calcium lactate350 mg/d from food

Placebo tablets were taken 3x/dayCa carbonate

supplementCalcium carbonate + food

500 mg/d tablet / 350 mg/d from

Tablets were taken 3x/dayLactoval (70% Ca

phosphate, 20% 500 mg/d tablet / 350 mg/d from

Tablets were taken 3x/day

foods, calcium-fortified foods (but

calcium citrate (1400 mg Ca/d) or calcium citrate (1400 mg Ca/d) or 200 mg calcium and 800 IU

4 supplement pills per day made

two 250 mg chewables with

Supplementation ergo-calciferol

Every 4 months (Two 1.25 mg vit

Supplements (Caltrate 600+D)

Ca: 1200 mg (Ca carbonate per

daily for last 3 mo pregnancyVit D 200,000 IU

1x!x at 7 mo pregnancy

Ca-Tablet as calcium carbonate

Ca 1000mg VitD3 400IUcalcium 375 mg and Vit D 1200 IU

unclear if this is oral or parenteral

600,000 IU once each in 7th and

Ca 500 mg/d + No vit D

calcium 500 mg/d + No vit DCa 500 mg/d + vit

D 125 ug/dcalcium carbonate + vit D2 (Spedrog-

calcium 500 mg/d + 5000 IU/d vit D2

2 drop qd of vit D2 + 1 tablet of Ca 500 mg/d + vit

D 250 ug/dcalcium carbonate + vit D2 (Spedrog-

calcium 500 mg/d + 10000 IU/d vit

4 drop qd of vit D2 + 1 tablet of

No intervention, usual dietSupplementary Ca (87% of Calcium Advised to consume 3

400 mg calcium/portion

Advice to consume dairy Calcirol (brand

name of 8571 IU cholecalciferol

120,000 IU sachets given 3 Identical to vit D

in color, taste, and Placebo sachets given 3 times,

Placebo nd nd nd ndCalcium Ca carbonate 8 wksVit D + Ca 8 wksPlacebo nd nd nd ndCa supplement 1 g (elemental) 5 yearsCholecalciferolPlacebo nd ndVit D + Ca 1 yr

1 yrCa + placebo 500 mg Ca 1 yrCalcium 2,000 mg One year ndPlacebo nd nd nd ndVit D 1 cap q 4 moPlacebo Matching placebo nd nd ndCalcium 1500 mg Ca++ 6 weeks Three times a dayPlacebo 0 mg Ca++ 6 weeks Three times a dayPlacebo Not Applicable 7y Taken twice dailyVit D + Ca 7yCalcium supplement 2000 mg/d 9 monPlacebo nd nd nd ndCa supplement Ca carbonate 1 g 18 mo 500 mg 2x/dayPlacebo nd nd nd ndCalcium Calcium carbonate 1 g Ca 6 mo.Placebo nd N/A 6 mo.Ca + Placebo Ca 1200 mg 5yVit D + Ca 5yPlacebo n/a 5y n/aCa + Placebo 1000 mg/d 1 yrVit D2 + Ca 1 yr

1200 mg elemental Ca

Capsules were taken 2x/day Ca carbonate Vit

D31200 mg elemental Ca and

Capsules were taken 2x/day

Calcium citrate (Citracal)

2 x 200 mg before breakfast; 3 x 200 Prepared in

Arachis oil by a 2.5 mg (100,000 IU)

Follow-up assessment 5 wks

One time drink taken in presence Prepared in

Arachis oil by a One time drink taken in presence Vit D capsules

from Jenapharm, 5714 IU cholecalciferol +

2 capsules each containing 20,000 Vit D + Ca +

placeboVit D capsules from Jenapharm,

2857 IU cholecalciferol +

1 capsule containing 20,000 Ca supplement

Nycoplus Ca, 2 placebo capsules taken Sandoz (calcium

lactate-gluconate,

Vit D3 (cholecalciferol)

100,000 IU q 4 months (~833

5 years (15 total doses)

Calcium powder containing calcium Placebo powder containing citric identical appearing placebo VitD GlaxoSmithKline

VitD 400 IU + Ca 1000 mg

200IU of VitD twice daily 500mg A 1000mg tablet was take with

Pills were taken 2 times a dayPills were taken 2 times a dayCa (Caltrate;

Wyeth Consumer 600 mg of Ca twice/dayCa (Caltrate;

Wyeth Consumer Ca 1200 mg + VitD2 1000 IU

600 mg of Ca twice/day + 1000 Placebo Ca (nd) +

Placebo vitD (nd)Calcium citrate (Citracal; Mission

Consume with evening mealOstelin; Boots

Healthcare, North 1000 IU vit D2 + 1000 mg/d Ca

Consume with evening meal

nd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndNoneNonend ndnd ndnd ndnd nd

nd ndnd ndnd ndnd ndnd ndnd nd

nd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndNoneNonend ndnd nd

Co-interventio

Compliance/Adherence

Calcium: 396 (54%) alive, Calcium: 396 (54%) alive,

Hormone therapy, dietary

No information on adherence rate Hormone therapy,

dietary No information on adherence rate

Hormone use was similar in both

60%-63% during first 3 years of

50% (no information on 50% (no information on

Calorie restriction in both groups

7 dropped out from not being

nd ndnd ndnd ndnd ndnd ndnd nd

nd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd nd

ndnd

nd ndnd ndnd ndNoneNonend ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndNoneNoneNonend ndnd ndnd nd

Calorie restriction in both groups

7 dropped out from not being All received

prenatal vitamin nd (but all had to meet a All received

prenatal vitamin nd (but all had to meet a

Only those subjects who

All subjects were advised to eat all Only those

subjects who All subjects were advised to eat all Only those

subjects who All subjects were advised to eat all

Energy restriction diet: -700 Kcal/d, Energy restriction diet: -700 Kcal/d,

60% (proportion taking study 60% (proportion taking study

Dairy group 93% (assessed via Dairy group 93% (assessed via Dairy group 93% (assessed via

nd ndndndNoneNonend ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd ndnd nd

nd ndnd ndnd ndnd ndnd ndnd ndNoneNoneNoneNoneNone

Assessed by pill counts, 95 12% Assessed by pill counts, 95 12% Calcium: 396 (54%) alive, Calcium: 396 (54%) alive,

54%of the participants

During year 1, 60% of the 54%of the

participants During year 1, 60% of the

Measured by counting tablets Measured by counting tablets Measured by counting tablets Tablet counting, 86.7% and 86.8% Tablet counting, 86.7% and 86.8%


Last Updated


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supplementation on bone Andersen R., Mølgaard C., Skovgaard LT., Brot C., Intake of potassium,









































and vitamin D with risk of Hartman TJ., Albert PS., Snyder K., Slattery ML.,


The impact of calcium and dairy product consumption

Harvey-Berino J., Gold BC., Lauber R., Starinski A.Gestational calcium






products, calcium and Järvinen R., Knekt P., Hakulinen T., Aromaa A.Dietary intakes,









fatty acid, and calcium Kurahashi N., Inoue M., Iwasaki M., Sasazuki S., Girls on a high-calcium

































199820072007200720072007200720092001199920002005200320071997200419991995200220062006199320082009200619972002198720032005200620081986200720062006200620081996200819971987200220071995199820082008

Serum vitamin D metabolite levels and the

Nomura AM., Stemmermann GN., Lee J., Calcium and vitamin D
















































Arm Location N enrolled N analyzedTotal Total 1530Total Total 715 ndTotal Total US, various 39,800 ~54 (~9)Total Total 118Total Total 6686 36 (~11)Total Total 199 147Total Total US, various 43,738 43,738 (implied) ndTotal Total 672 61.8 (8.7)Total Total U.S. 57 (7.0)Total Total 218 218 84.5Total Total Boston, US, 42 N 389 (original trial) 70 (4.9)Total Total Pittsburgh, PA 24 (est.)Total Total 1471 1471 74 (~4.2)Total Total UK 123 106Total Total 10 10 22.2 (1.2)Total Total 41837 35216 61.5 (nd)Total Total Iowa ~42 34,486 34,486 61Total Total 183 Mode 55-64 (51%)Total Total US 40 centers ndTotal Total Chile (32.26 S) 96 92 76 (4)Total Total 205 199 83.0 (7.6)Total Total US 36282 36282 ndTotal Total US 22071 20885 53.3Total Total US 38 N 68.132 36,282 ndTotal Total 195 165 11.2Total Total 73 57 61(5)Total 57 (nd)Total TotalTotal Total US, various 6634 6634 46 (~14)Total Total Indiana 40 N 154 51 19.4 1.6Total Total 179 168 13.2 (no sd)Total Total 255 255 newbornTotal Total 576 60 (no SD)Total Total 61431 61.9 (nd)Total various 1811Total Total US 43 (nd)Total Total 16818 16818 44.0 (nd)Total Total 2010 66.5Total 50535 50535 43 (nd)Total Total Southampton, UK 466 440 26.3 (est.)Total Total 62 yrsTotal Total Chicago, US 41 N 2107 1954 48.7 (4.4)Total Total 101 62.8 (no SD)Total Total 265 158 Maybe ~80Total Total 930 822 60.6 (no sd)Total Total Boston, MA 20 18 Young: 26 Old: 69Total Total 2079 1905 61.1(9.9)

Arm Description

Mean (SD) Age, yrUnited States

(various): 1530 749 cases; 781 controls

Case: 67.8 (5.3); Control: 67.6 (5.3)Finland 62

(various cities)715 cases: 149 control: 566 39,800 (415,965

person years)Mineola, NY, USA, 40

64 (+30 in HRT arm)

-Calcium group: 52(0.6) yrs -Navarra, Spain 42

40~7470 (incl missing data)Copenhagen area,

Denmark (55 N )Median age - Adolescent girls:

Cleveland Clinic Dartmouth

672 542 w/ full PSA data (58% of 1459 735 with

breast cancer 724 1425 (701 breast cancer and 724 Helsinki, Finland

60 10' North 257 (for this study)1198 in the

eligible cohort; 55 49 cases; 216 controlsAuckland, New

Zealand 36 Vit D+Ca: 69.4 (6.4) Placebo: 67.8 Lausanne,

Switzerland Iowa, US (40 23 -40 30 N)

Washington County, MD 39.7

183 (61 cases, 122 controls)36,282 joined at the initial stage of

2928 had objective physical

Scotland (55 57' N)

Jyvaskyla, Finland 62 24'NNew Brunswick, NJ, USA 40.486San Francisco Bay area, US 37 46'

200 cases 200 controls

181 cases 181 controlsBratislava, Slovak

Republic (48 40' Patients with polyps and

Patients with polyps and

Patients with polyps and

Greater Beirut area, Lebanon (33 Beijing (40 N); Jiamusi (47 N); US (various latitudes)

Original cohort (N=121,700), 27 cities across

the US (25 46'-54 45354 (details on the reasons for 1811 (613 men,

1198 women)Men: 65 8 years Women: 57 7 116,671 Female

registered nurses 742 cases and 742 controlsUS Mean

latitude=38.3N10 US centers 38 00 N

1,005 cases and 1,005 noncasesNorway (Finnmark

[69 44 N], Sogn

United States (multiple

22,071 in original cohort, 520 cases

232 cases and 414 controls

Washington county, Maryland

Original Cohort (n=25620) Cases Montreal, Canada

45.7US The Cleveland Clinic Foundation

US 38 N, 8 clinical centers

Total Total 54 44 45.2(6.7)Total Total Portland, OR 45.5 497 62 ndTotal Total 67 67 38.7 (11.2)Total Total 464 320 52.9(0.29)Total 519 477 ndTotal Total 249 68Total Total Finland (64 00 N) 9959 9959 39.1 (nd)Total Washington DC 322 322 21.6Total Total 67 67 49.1 12.1Total Total 3500 (see above) 3111 ~61 (nd)#Total Total 14727 14727 ndTotal Total 47935 47239 ndTotal Total France 46 N 100,000 52.7 (nd)Total Total France 46o N 3836 3627 51 (6.3)Total nd 11014 10011 67Total Japan 36 N 46,036 ndTotal Total Omaha, NE 41 N 63 59 9.5Total Total Nebraska, 41.4 N 1180 1179 67 (7.3)Total Total 5201 3700 Median: 19Total Total 48850 45306 60.3 (nd)Total Total 48850 45306 60.3 (nd)Total Total 26556 26556 ~57 (nd)Total Total Sweden 62 N 61,433 36,664 53.7(9.7)Total Total 2684Total Total 32 32 24 1Total Total 36976 36976 Nd (~54 y)Total Total US 26 - 61 31487 31487 55 yTotal Total 113 110 13.2Total Total 3440 3343 84 (7.5)Total Total 84 63 43 (~5.5)Total Total NW France, 48 N 77 77 25Total Total US 36282 36282 62 (7)Total Total Turku, Finland 60 769 755 79 (nd)Total Total 1429 1304Total Total 400 400 ndTotal Total 200 200 24Total Total 45 45 65 (median, est.)Total Total London, UK 51 N 126 126 ndTotal Total US (21 states) 127749 127749Total US 30 N 97,786 68,567 63 (nd)Total 13331 13331 44.8Total Total 54 N 1471 1161 51.5Total Total Finland 64 N 29133 27028 56.7 (est.)Total Total 475 374 29Total 4314 4157 79% age 17-24Total Total 112 101 61 (nd)Total Total 100 44 (8)Total Total Bangor, ME 112 women 86 women 22.2 (3.7)

Vermont, USA 44 N

Omaha, NE 41.2 NKuopio Province, Eastern Finland Oahu, HI [21 19'N]Eastern United States (25 46 N

1312 in original cohort, 249 with

Prague, Czech Republic. 50 NNetherlands (nd) (52 30 N)New York City, NY (40 47 ) or US (25 46 - 54 40 N) Adenoma study:

5320 CRC: 67484

65,801 men in initial cohort

Great Lakes, IL, USA 41 NorthSweden (Vastmanland [59 Sweden (Vastmanland [59 Southwestern Finland ~60

United States- multiple locations

1156 492 cases 664 control

58.9 8.3 at study onset. 69.3 7.3 Leuven, Belgium

51US (25 46 -54 40 )

Frederiksberg, Copenhagen, South Wales (51.96 N)Quebec City, QC, Canada 47

Phoenix, Arizona, metropolitan area

According to calcium intake, Rohtak, India 28

54 NRohtak, India 28 54 NBuenos Aires, Argentina (34 S)

According to calcium intake per

nd (multiple cities in US)

Geelong, Australia 38 SAlbuquerque, NM; Birmingham, AL; Greece (Nea Smyrni, Kalluthea New Delhi, India (28 N)

71 (ITT analysis) 65 (per protocol

Total Total 272 272 58 (nd)Total Total US (38 N) 121700 48115 ndTotal MA 41 42 N 1718 1718Total Total 1125Total Total 215,000 191,011 ndTotal 339671 293888 ndTotal Total 82,483 ndTotal ndTotal Total 148 145 75 4 yrs.Total Total 27111 27111Total Total 652 652 58.5 6.6Total Total 1471 74 (~4.2)Total Total 65,321 ndTotal Total 5620 3892 53.8 (nd)Total Total 18,244 ndTotal 842 842 85 (nd)TotalTotal Total 191 189 69.6 (nd)Total US 88691 88381 46.7 (nd)Total Total 73314 73314TotalTotal Total 3091 2591Total Total 445 334 47.6 (11.4)Total TotalTotal Total Finland 64 N 58Total Total Median 60Total 61463Total Total 28 28 ndTotal Total 2686 2686 75 (5)Total 14407 3779 57.8(14.6)Total Japan, various 53,387 53,387 56Total Total 41,526 41,526 ~49 (nd)Total Total 58 58 21(1.0)Total 1343 families 4374 children 7.6 (sd, nd)Total 1260 1260 65 yTotal Total US (38 N) ndTotal Total 19 19 29Total Total 1739 59 (9)Total Total 44# 30 62 (nd)Total Total Taiwan 3282 1772Total Total 10 sites 471 445 43~+/-6.6Total 11,888 11,644 ndTotal HPFS: nd NHS: USTotal Total US, various 535 66.2Total Total US, various 471 43 6.5Total Total 34702 34702 ndTotal Total Western Australia 120 120 74.8 (2.6)Total Total 302 256 77 (4.5)

Oahu, Hawaii 21 N

68% age 30 to <40Japan (~ 30 40

N)Original cohort (N=133323),

Men 56.9 (no SD) Women 56.4 (no Hawaii (21 N) Los

Angeles, California CA, FL, LA, NJ, NC, PAHawaii (20 N) and California

Original cohort of 215,000 men and California, Florida,

Louisiana, New N=492,810 (M=293,907,

N=492,810 (M=293,907, Lower Saxony,

Germany 52 NSouthwestern Finland

Median, cases: 60.1; non cases: US, various

locationsAuckland, New Zealand (36.5 S)

1471 (ITT), 153 withdrew prior to United States

(various)86,404 male participants in the Washington

County, MarylandShanghai, China 31 N

245 cases 1225 controlsN. Sydney,

AustraliaNetherlands, 52.30 N

2392 (original cohort size =

2167 (642 cases, 1525 controls)

Cases: 63.9 3.8 Controls: 61.4 4.2Cambridge, UK 52

N

urban Shanghai, China (31 14' N)

Cases: 59 (8.5); non-cases: 52 Multiple cities in

USNHS: 121,701 HPFS: 51,529

NHS: 75,427 HPFS: 46,771

NHS: 51 (nd) HPFS: 55 (nd)Amsterdam (52

18' N)Men 53(7.3) Women 52 (7.2)North Norway

(latitude = 70 N)Multicenters in the US: Birmingham,

Original RCT participants:

Cases: 184 Controls: 368

Cases: 66 Controls: 66200 cases 400

controls200 cases 400 controlsSouthwestern

Finland (~ 60 N)438 (146 cases, 292 controls)

436 (146 cases, 290 controls)Vastmanland

county (59 45'N) 61463 This number is smaller

According to calcium intake Copenhagen,

Denmark 55 40 UK (Oxford [52 N] & Ipswich [52 N])United States various, excluding

4 areas Japan Okinawa (24 ) to Netherlands (52 N)England (54 N) Scotland (55 57' W, NE, S of the Netherlands RCT part: 36282

(Ca+vitD RCT part: 36282 Case-cohort part: Charleston, SC 32

47'NProbably mostly still around

1739 (Originally 5124)Heidelberg and

surrounding Stroke group = 62.6(8.1)

About 50 miles south of Los HPFS: 47344

NHS: 87998HPFS: 47344 NHS: 87998

HPFS: 54.4 (nd) NHS: 46.6 (nd)Original cohort

(N=51,129), 447 at 3 mo. 438 at 6 mo.Iowa, US (40 23

-40 30 N)

Perth, Australia (32 S)

Male %nd 100% nd40-57 100% nd nd nd nd40-75 100% ~25.5 ~3.4 Healthy ndnd 0% White 100% nd nd20-90 39% BMI 23.1 No HTN nd

42 Pakistani Generally healthy No hypercalcimia40-75 100 mostly White nd Healthy ndnd 100 nd ndnd 0% nd65-104.3 18.4 nd nd65-86 47 97% white 45% BMI 25-30 healthy20-29 (est.) 0 nd55 y 0 nd BMI 26.4 healthy60 0 nd Mean BMI: 26 Healthy ndnd 30% nd Overweight/obesend 0% nd nd55-69 0 White ~100% ~27 Healthy nd<45 75+ 100% White 100% nd50-79 yr 0 nd nd nd ndnd 11.6% nd Healthy elderlynd 40% nd nd50-79 0nd 100 nd BMI=24.9 nd nd50-79 010-12 0 nd BMI: 18.252-75 0% nd BMI: 26.9(1.9) nd nd38-81 100 nd nd nd

nd nd nd25-74 63% BMI 25.4 No HTN ndnd 0 nd nd nd10-17y 0% nd Healthy ndnd nd Asians nd nd43-70 (inclusion) 0% nd BMI 25.1 ndnd 0% ndnd 34% BMI ~ 25 4 nd40-46 0 nd BMI 24.1 nd ndnd 45.4 ndnd 0 ~90% Caucasian ~2120-53(invited) nd nd ndnd 0 Caucasians nd

100% nd nd nd ndnd 100 BMI 25.5 nd ndnd 49.5% White: 100% nd nd nd

0% 59.7 Kg Healthy ndnd nd nd nd ndnd 100 nd ndnd 64 Caucasian 90% nd nd nd

Age Range/1QR

Race/Ethnicity

Anthropometry data

Health Status

Specific Nutrition Non-Hispanic

whiteBMI case 27.3 (3.6); BMI control

No prior history of cancer before

White close to 100% -Weight: calcium

group 65.8 (1.5) nd (educated Spaniards)Range

Adolescent girls: Median BMI - Adolescent girls:

African American: 5.4%

From Baron NEJM 1999 paper: Had BMI at age

18=21.1 BMI at Post menopausal 68% Ever smokers

Plasma 25 (OH) D at 1989-1990 31.5 All required

assistance of >2 Frail and chronically Mean Vit D 189 IU/d; Ca 721 mg/d78% white (in

cases); 68% white prepregnancy BMI 25 = 58% of

no preexisting medical conditions 25(OD)D 25

nmol/L

Weight(kg) = 78.1 (9.1) Height(m) =

Ca intakes < 800 mg/dBMI=27.0 kg/m2

Height=64.1 Total energy intake=1801.5

No prostate cancer at baseline

<5% with baseline 25(OH)D <15

BMI 28.8 kg/m2 Weight 65.6 kg

serum vitamin D of 16 ng/ml or lessUnder weight 40%

Normal weight Inpatient with high levels of White 83% Black

9% Hispanic 4% BMI <25 28% 25 to <30 35% 30

Healthy, post-menopausal

Total Ca intake <600 mg/d 20%

CaD: White 82.8% Black 9.3%

CaD <25 26.2% 25-<30 35.8%

CaD : Alcohol use in Non drinker

Baseline vitD supplementation: no serious medical

conditionsdietary calcium: 670 mg/d; vit D

Black 91 pairs White 90 pairsPatients with

polyps and Patients with polyps and

Patients with history of polyps, White 86% Black

14% BMI: 22.31 Weight: 62.4kgHeight 152.7cm Weight 47.3 kg % 6 mo weight: 7.8 Kg; length; 67 cm Aspirin user

(>10y): 10% HRT BMI=24.7 kg/m2 Ht=64.0 (inches)

Some with previous breast

Total energy intake ~1273 - 95% of men and

85% of women Low vit D intake in part of cohort

Non-Hispanic white: 71.2 Non-

BMI=26.7 kg/m2 %body fat=23.4

Vit D: 4.7 mcg/d Ca: 811.8 mg/dEver smoker ~37-

47% History of Total calcium intake 1.1 to 1.7 49% (male and

female were Male Total energy: 2033.7 prepregnancy wt:

59 Kg (est.)vit D intake (food & supplements): 40-84 yrs at

baseline 65% Americans of Germen, Polish, or

50-69: 25% 70: 75%

Probably almost all whiteMale 71.7%

Female 28.3% BMI Young: 26.6 Old: 31

vit D intake Young: 51 IU/d

18-60 7% nd nd ndnd 0 nd nd Healthy ndnd 100 nd BMI 26.2 (2.4)47-56 0% nd 26.4(0.47) nd nd46-68 100% Japanese nd ndnd 100 white 26 nd15- nd nd BMI=24.8 kg/m2 nd16->31 (est.) 0 African American ndnd 0% nd nd nd

~49%# nd nd nd ndnd 0% nd nd40-75 100% nd BMI=25kg/m2nd 0% nd BMI 23.0kg/m2 nd ndnd 0% ndnd 100 nd 43% with BMI>25 nd nd45-74 100% nd nd nd ndnd 0 BMI 17 ndnd 0 white BMI 2917-35 0nd 100% nd BMI=25.8kg/m2nd 100% nd BMI=25.8kg/m250-69 100 ~26.5 Healthy ndnd 0 Swedish BMI 24.8(3.9) nd ndnd 100% nd20-44 y 100 nd Healthy

0% nd BMI=~2655-56 0% nd BMI = 26nd 0 white wt 51 Kg nd62-107 23.7% nd nd nd nd

0 nd BMI 31.9 (~3) nd18-36 0 white nd nd50-79 0% healthy nd65-99 48% nd nd ndnd 57.1 nd nd20-35 0 Indian nd nd22-35 0 Indian weight 54 Kg nd54.5-77 (IQR, est.) 0 nd BMD T-score < -1nd 0 Asians ndnd 48 ndnd 0 nd>=20 46 Mean BMI: 26.85nd 0 nd nd ndnd 100 Caucasians BMI 26.5 (est.)nd 0 99% white Ht 166 cm ndnd 0 nd55-65 0% 100% Greek nd ndnd 100% Indian19-35 y 0 Healthy nd

BMI = 30(2.5), weight = 81(9),

good general health

est. <5 g/d intake of vit D

Total fat: 75 g/d Ca: 575 mg/dsome subjects

were on Se to Total energy=2602.6Kc42% 90-110% of

ideal Calcium 933.4 51.8 (SE) mg/d BMI=32.2 4.1

Weight=84.5 13 55-69 (per inclusion criteria) [Based on only

11573 [based on only 14724 Family history=8.4%

Total energy intake=1958.7

BMI: <18.5 = 4.4% = 75.8%

Post-menopausal status 52% cases;

Energy adjusted calcium intake

95% white 5% black

dietary intake calcium: 819 mentally and

physically fit to baseline 25(OH)-D 71.8 20.3 nmol/LAmerican Indian:

3%, Asian: 4%, Mean BMI = 24 (ranged 15-43)

Assumed healthy (Navy recruits)

Mean dairy servings/wk = 6 Hx of DM=6.1%

Aspirin Vit D=6.4 g/d Saturated fat 33.5 Hx of DM=6.1%

Aspirin Vit D=6.4 g/d Saturated fat 33.5 Mostly white

(implied)

6% not of European descent

Age at study onset: cases =

-Vit D deficiency (<20 ng/ml) in Weight 75.9 1.3

Kg1 month low Ca diet run-in45 or over

(enrollment of the FH of colorectal cancer=~10%

Total energy intake=~1700 Current smokers

= 8% to 20% Current users of multivitamins, dietary calcium: 957 mg/d

nd (premenopausal)

Healthy, overweight/ obese Ca intake 550 to

1000 mg/d in 55% 83% White, 9% Black, 4%

BMI <25 28.0% BMI 25 to <30 White 100%

(probably) Regular aspirin use in the past 10

According to calcium intake diet: calcium 500 mg/d and vit D 40 Vit D 35 IU/d; calcium 429 mg/d BMI 27.4 (median,

est.)25(OH)D level 42 nmol/L (median, weight at 3rd

trimester: 63.7 Kg25(OH)D level at 28-32 wk: 20.1 According to

calcium intake per According to calcium intake per

According to calcium intake per Mean body mass

index in 1992 = Current smoker 5 to 13%

Total calcium (mg/d) = 706-Non-Hispanic

white: 72.9%, non-Diabetes: 7.4% History of CVD:

Use of vitamin D supplement: Intake levels available as smokers at

baselinevit D 5.4 g/d mean intake (est.)25(OH)D in winter: 49.2 nmol/L; 51% white; 46%

African American38% with BMI 26

dietary calcium pre-intervention: Weight - 72.9 kg

Height 157.2 BMI = 26.4 (4) Waist

apparently healthy ,

Most subjects severely vit D Predominantly

white womenBMI 25.9 % body fat 30.1% Height

49-70 100 Hawaiian Japanese nd ndnd 0% nd BMI 24 nd ndnd 0 nd nd40-69 52% nd ndnd 45% nd nd nd50-71 100 92% white (est.) BMI 27.2 (est.) nd45-75 100% nd nd nd50-71 (range) 60%

0% nd ndnd 100 Finishnd 0% nd nd55 y 0 nd BMI 26.4 healthy50-74 100% nd BMI mean = 26.1 nd ndnd 100 99% white BMI 27.2 nd45-64 100% Chinese nd ndnd 22 nd 60 Kg ndRange: 55-69 yrs 100% nd nd nd nd

46% nd Healthy ndnd 0 nd ndnd 0 Chinese

NHS: 0 HPFS: 100 nd40-65y 50.9% nd nd ndnd 36% nd

65.254-62 100% Caucasian BMI 26 kg/m250-69 100 nd nd ndnd 0 Swedish ndnd 0% nd nd nd nd65-85**** 76 nd BMI=24.425-74 100% nd nd nd40-79 39% Japanese Healthy nd40-59 48% Japanese ~23.5 Healthy nd20-23 0% nd nd nd4-11 yr 49.5% nd nd nd65 to 80 y 51 nd BMI <25 to 30 nd50-79y 0% nd ndnd 0 89% white nd ndnd 45% White 100% BMI 28.1 No CVD, CKD46-75 53## nd ndnd 44% nd nd30-54 68% 86% white ~83 Kg BMI ~27 nd

~33% nd nd ndHPFS: nd NHS: nd HPFS: 100 NHS: 0 HPFS: nd NHS: ndnd 100 nd BMI 25.7Age range: 30-54 69% BMI=27.4 3.7 healthy

0 nd ndnd 0% nd nd70 to 90 0 nd Mean BMI = 29

22 pack-years smoked

72% white; 12% black

67% prepregnancy BMI (Japanese or Asian

~100%)BMI Men: 23.4 Women: 23.6African Americans,

Native Hawaiians, calcium from non-dairy food (346-African Americans,

Native Hawaiians, White (non-Hispanic): M=

BMI: M= ~27.2 F= ~26.7

Family history of any cancer: M=

Ca-containing multivitamin user: Age range = 70

86 yrs.Mean weight = 65 kg. Mean height =

25(OH)D < 50 nmol/LMedian BMI

(kg/m2), cases: Physical activity (moderate), cases:

Median daily energy intake BMI 25.0 kg/m2

Mean physical Regular aspirin use: 26.1% 25(OD)D 25

nmol/L

25% used calcium supplementsBMI quartiles:

<20, 20-<22, 22- 7.2% DM; 62% HTN

Age range: 63 76 yrs.

Mean weight = 70.3 kg. Mean BMI Mean BMI at age 18y: 21.4, Mean

History of osteoporosis: BMI, average

(Kg/m2): 24 Waist Menopause: 49% CRC in first degree

Fruits/vegetables intake (g/day), NHS: 30-55 HPFS:

40-75Mean BMI - NHS: 24 HPFS: 25

Diabetic NHS: 3% HPFS: 1%

Residence in northern state BMI Men 24.7

(2.7) Women 26.4 Weight(kg)=100.1 (14.2)

Overweight or obese, 22%

Serum Ca(mmol/L)=2.31(Cases: IQR 59-72

Controls: IQR 58-90.2% White, 3.3% Black, 1.6%

Mean (IQR) BMI Cases: 26.7

DM: 10.5% Gallbladder

Vit D inadequacy (<40 nol/L): 14%Diabetes 9%

Bronchial asthma Vit D food 5 g Supplement 8% Wt=79.1

BMI=26.3According to calcium intake

Calcium intake, median (mg/day):

Hx of CAD: 16% Hx of stroke: 4%

Mean total Ca intake at 4 year White 88%, Black

11%, Other 1% Men 22.7 Women 22.9

Bodyweight = 49-76 kgHeight z score: -0.01 BMI z score: 31-41% with CVD;

44-59% with White 83.1% Black 9.1% Hispanic

Previous polyps: 8% Family Hx: dietary calcium

intake: 1125 Vit D supplement 4% Multivitamin nd (other than

previously Total: 2638 (kcal/d) Fiber: 33 Mean BMI stroke

group=25.3(3.4) 10.5% diabetics, 4.2% self-report Healthy Borderline DBPnd (to adjust for

age, the cohort 100% Caucasian (upper-middle HPFS: Average

BMI (kg/m2): 25.5 HPFS: %current smokers: 9.6;

HPFS: Average total energy Aspirin use in

1994: 40% Vit D: 455.7 IU/d Ca: 939 mg/d86% white 10.5%

blackCa intake= 970mg/d 24-hr 55-59 years old:

107377 person-yr; Pack-yr of smoking: Never

Total energy intake (tertile, nd (some

subjects, unclear living in sunny climatend (based on the

inclusion and Mean 25(OH)D = 44 nM Only 37%


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Alt ID(s) Title Year Author20082008200020002000200320032003199520052008200820081992199619981998200520052005200520082008200820072008200820082008200820072007200819931999199520082008200820062006200620062006200620072007

OutcomeSerum vitamin D

concentration and Ahn J., Peters U., Albanes D., Purdue MP., Abnet CC.,

Aggressive prostate Serum vitamin D

concentration and Ahn J., Peters U., Albanes D., Purdue MP., Abnet CC.,

Prostate cancer Prostate cancer risk and

prediagnostic serum 25-Ahonen MH., Tenkanen L., Teppo L., Hakama M.,

Prostate cancer Prostate cancer risk and


Prostate cancer in Prostate cancer risk and


Prostate cancer in A prospective study of

calcium intake from diet Al-Delaimy WK., Rimm E., Willett WC., Stampfer MJ.,

Fatal IHD [Including A prospective study of


IHD (fatal + nonfatal) A prospective study of


Nonfatal MI [Self-The influence of

menopause and hormonal Aloia JF., Vaswani A., Russo L., Sheehan M.,

Body weight Low-fat dairy consumption

and reduced risk of Alonso A., Beunza JJ., Delgado-Rodríguez M.,

HTN, incident Effect of vitamin D

supplementation on bone Andersen R., Mølgaard C., Skovgaard LT., Brot C.,

25(OH)D [ContinuouEffect of vitamin D


BMC - whole body Effect of vitamin D


BMD - lumbar A prospective study of

nutritional factors and Ascherio A., Rimm EB., Giovannucci EL., Colditz

Incident HTN Prospective study of

nutritional factors, blood Ascherio A., Hennekens C., Willett WC., Sacks F.,

Hypertension Intake of potassium,

magnesium, calcium, and Ascherio A., Rimm EB., Hernán MA., Giovannucci

Incident stroke Intake of potassium,

magnesium, calcium, and Ascherio A., Rimm EB., Hernán MA., Giovannucci

specific stroke Risk of prostate cancer in

a randomized clinical trial Baron JA., Beach M., Wallace K., Grau MV.,

Prostate cancer risk Risk of prostate cancer in

a randomized clinical trial Baron JA., Beach M., Wallace K., Grau MV.,

Total serum PSA Plasma 25-hydroxyvitamin

D and 1,25-Bertone-Johnson ER., Chen WY., Holick MF., Hollis BW.,

Breast cancer risk Plasma 25-hydroxyvitamin


Breast cancer risk Vitamin D

supplementation has Björkman M., Sorva A., Risteli J., Tilvis R.

25(OH)D level Vitamin D

supplementation has Björkman M., Sorva A., Risteli J., Tilvis R.

Mortality [All Body size and serum 25

hydroxy vitamin D Blum M., Dallal GE., Dawson-Hughes B.

25(OH)D at 1 y Maternal vitamin D

deficiency increases the Bodnar LM., Catov JM., Simhan HN., Holick MF.,

preeclampsia Vascular events in healthy

older women receiving Bolland MJ., Barber PA., Doughty RN., Mason B.,

CVD Composite Vascular events in healthy


Death [Family, Vascular events in healthy


MI [Standard Vascular events in healthy


Stroke [Standard Vascular events in healthy


Sudden death Two-year randomized

controlled trial of vitamin Bolton-Smith C., McMurdo ME., Paterson CR., Mole

25(OH)D [Measured Two-year randomized

controlled trial of vitamin Bolton-Smith C., McMurdo ME., Paterson CR., Mole

Femoral neck BMD Dairy calcium

supplementation in Bortolotti M., Rudelle S., Schneiter P., Vidal H.,

Weight [ContinuouRelation of calcium,

vitamin D, and dairy food Bostick RM., Potter JD., Sellers TA., McKenzie DR.,

Colon cancer Relation of calcium,

vitamin D, and dairy food Bostick RM., Kushi LH., Wu Y., Meyer KA., Sellers TA.,

IHD death [CategoricProstate cancer and

prediagnostic levels of Braun MM., Helzlsouer KJ., Hollis BW., Comstock GW.

Prostate cancer Calcium, vitamin D

supplementation, and Brunner RL., Cochrane B., Jackson RD., Larson J.,

Chair stands Calcium, vitamin D


Grip strength Calcium, vitamin D


Timed walk [The timed Effects of vitamin D

supplementation and Bunout D., Barrera G., Leiva L., Gattas V., de la

25(OH)vitD [No assay Effects of vitamin D


Fall [Fall free Effects of vitamin D


Muscle strength Effects of vitamin D


Physical performanEffects of vitamin D


Timed up and go Effects of vitamin D


Twelve minutes Does vitamin D stop

inpatients falling? A Burleigh E., McColl J., Potter J.

Fall [Defined as Does vitamin D stop

inpatients falling? A Burleigh E., McColl J., Potter J.

fracture [Any

200720012008200520052005200420042004-- Not Found ---- Not Found ---- Not Found ---- Not Found ---- Not Found --1996199620062006200620062006200620062006200619941994200420042004200420052005200520072008200720072007200720072007200720072008199620082008

Calcium plus vitamin D supplementation and the

Caan B., Neuhouser M., Aragaki A., Lewis CB.,

Weight [Kg]Dairy products, calcium,

and prostate cancer risk in Chan JM., Stampfer MJ., Ma J., Gann PH., Gaziano JM.,

Prostate cancer Calcium plus vitamin D


Incident invasive Effects of calcium, dairy

product, and vitamin D Cheng S., Lyytikäinen A., Kröger H., Lamberg-Allardt

areal BMD [ContinuouEffects of calcium, dairy


bone indexes Effects of calcium, dairy


change in BMC (ITT Weight loss and calcium

intake influence calcium Cifuentes M., Riedt CS., Brolin RE., Field MP.,

25(OH)D [ContinuouWeight loss and calcium


Curve 4- Ca Weight loss and calcium


Weight change Vitamin D and prostate

cancer: a prediagnostic Corder EH., Guess HA., Hulka BS., Friedman GD.,

Prostate cancer Vitamin D and prostate


Prostate cancer Vitamin D and prostate


Prostate cancer Calcium chemoprevention

in colorectal cancer.Duris I., Hruby D., Pekarkova B., Huorka M.,

Adenomas recurrence Calcium chemoprevention

in colorectal cancer.Duris I., Hruby D., Pekarkova B., Huorka M.,

Survival [nd (only Dietary calcium, alcohol,

and incidence of treated Dwyer JH., Li L., Dwyer KM., Curtin LR., Feinleib M.

HTN (BP or Rx) [SBP Dietary calcium, alcohol,

and incidence of treated Dwyer JH., Li L., Dwyer KM., Curtin LR., Feinleib M.

HTN (Rx) [HTN Effect of 1-year dairy

product intervention on fat Eagan MS., Lyle RM., Gunther CW., Peacock M.,

BMI [ContinuouEffect of 1-year dairy

product intervention on fat Eagan MS., Lyle RM., Gunther CW., Peacock M.,

Weight [To the nearest Effect of vitamin D

replacement on El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J.,

25(OH)D [ContinuouEffect of vitamin D


Weight [ContinuouEffect of vitamin D


% change in BMC at Effect of vitamin D


% change in total hip Effect of vitamin D


1,25(OH)D [ContinuouEffect of vitamin D


Total body BMC Effect of vitamin D


height [ContinuouSeasonal and geographical

variations in the growth Feliciano ES., Ho ML., Specker BL., Falciglia G.,

length [ContinuouSeasonal and geographical

variations in the growth Feliciano ES., Ho ML., Specker BL., Falciglia G.,

weight [ContinuouPlasma vitamin D

metabolites and risk of Feskanich D., Ma J., Fuchs CS., Kirkner GJ., Hankinson

Colon cancer [nd]Plasma vitamin D


Colorectal cancer Plasma vitamin D


Proximal and distal Plasma vitamin D


Rectal cancer [nd]Calcium from diet and

supplements is associated Flood A., Peters U., Chatterjee N., Lacey JV.,

Colon cancer vs. Calcium from diet and


Colorectal cancer Calcium from diet and


Proximal vs. distal Plasma 25-hydroxyvitamin

D levels and risk of Forman JP., Giovannucci E., Holmes MD., Bischoff-

Incident HTN Plasma 25-hydroxyvitamin

D levels and risk of Forman JP., Curhan GC., Taylor EN.

Hypertension [Self-Prospective study of

serum vitamin D and Freedman DM., Looker AC., Chang SC., Graubard

Breast cancer Prospective study of


Cancer mortality Prospective study of


Colorectal cancer Prospective study of


Digestive cancer Prospective study of


Lung cancer Prospective study of


Non-Hodgkin s Prospective study of


Other cancers Prospective study of


Prostate cancer Serum levels of vitamin D

metabolites and breast Freedman DM., Chang SC., Falk RT., Purdue MP.,

Breast cancer risk Dietary factors and risk of

colon cancer: a Gaard M., Tretli S., Løken EB.

Colon cancer Maternal vitamin D status

during pregnancy and Gale CR., Robinson SM., Harvey NC., Javaid MK.,

9 mo length Maternal vitamin D status


9 mo weight

200820082008199619851989199519951995 SBP/DBP199520072007199919991999200520052005200320032003200319971986200420012001200119941994199420082008199419971996200520052007200620082004200420042007200720082006

Maternal vitamin D status during pregnancy and

Gale CR., Robinson SM., Harvey NC., Javaid MK.,

atopic eczema at Maternal vitamin D status


birth length Maternal vitamin D status


birth weight Circulating vitamin D

metabolites in relation to Gann PH., Ma J., Hennekens CH., Hollis

Prostate cancer Dietary vitamin D and

calcium and risk of Garland C., Shekelle RB., Barrett-Connor E., Criqui

Colorectal cancer Serum 25-hydroxyvitamin

D and colon cancer: eight-Garland CF., Comstock GW., Garland FC., Helsing

Colon cancer The influence of dairy


DBP [ContinuouThe influence of dairy


SBP [ContinuouThe influence of dairy



Weight [Kg:ContinProlonged effect of

calcium supplementation Grau MV., Baron JA., Sandler RS., Wallace K.,

Advance adenomas Prolonged effect of

calcium supplementation Grau MV., Baron JA., Sandler RS., Wallace K.,

All adenomas Plasma 25-hydroxyvitamin


25(OH)D total [sum Plasma 25-hydroxyvitamin


25(OH)D2 [ContinuouPlasma 25-hydroxyvitamin


25(OH)D3 [ContinuouThe association of calcium


Advanced adenomas The association of calcium


Recurrent adenomas The impact of calcium and

dairy product consumption Harvey-Berino J., Gold BC., Lauber R., Starinski A.

Body weight Gestational calcium

supplementation and Hatton DC., Harrison-Hohner J., Coste S., Reller

DBP [ContinuouGestational calcium


SBP [ContinuouGestational calcium


BP (post-partum)Human serum 25-

hydroxycholecalciferol Heaney RP., Davies KM., Chen TC., Holick MF.,

slope [ 25(OH)D/ Long-term vitamin D3

supplementation may Heikkinen AM., Tuppurainen MT.,

Body weight Colon cancer and dietary

fat, phosphorus, and Heilbrun LK., Hankin JH., Nomura AM.,

Colon cancer Plasma levels of 25-

hydroxyvitamin D, 1,25-Jacobs ET., Giuliano AR., Martínez ME., Hollis BW.,

Prostate cancer Prospective study on milk

products, calcium and Järvinen R., Knekt P., Hakulinen T., Aromaa A.

Colon cancer Prospective study on milk


Colorectal cancer Prospective study on milk


Rectal cancer Dietary intakes,

anthropometric Johnson AA., Knight EM., Edwards CH., Oyemade

birth lengthDietary intakes,


birth weightDietary intakes,


gestational ageCalcium intake and the

outcome of short-term Kabrnová-Hlavatá K., Hainer V., Gojová M.,

BMI [ContinuouCalcium intake and the

outcome of short-term Kabrnová-Hlavatá K., Hainer V., Gojová M.,

weight [Analyzed Fermented dairy products,

calcium, and colorectal Kampman E., Goldbohm RA., van den Brandt PA.,

Colorectal cancer Prospective study of diet

and female colorectal Kato I., Akhmedkhanov A., Koenig K., Toniolo PG.,

Colorectal Cancer Calcium, vitamin D, and

dairy foods and the Kearney J., Giovannucci E., Rimm EB., Ascherio A.,

Colon caner Dietary calcium,

phosphorus, vitamin D, Kesse E., Boutron-Ruault MC., Norat T., Riboli E.,

Colorectal cancer Dietary calcium,

phosphorus, vitamin D, Kesse E., Boutron-Ruault MC., Norat T., Riboli E.,

adenoma [Complete Dairy products, calcium

and the risk of breast Kesse-Guyot E., Bertrais S., Duperray B., Arnault N.,

Incident breast Dairy products, calcium

and prostate cancer risk.Koh KA., Sesso HD., Paffenbarger RS., Lee IM.

prostate cancer Dairy product, saturated

fatty acid, and calcium Kurahashi N., Inoue M., Iwasaki M., Sasazuki S.,

Prostate cancer Girls on a high-calcium

diet gain weight at the Lappe JM., Rafferty KA., Davies KM., Lypaczewski

change in BMI Girls on a high-calcium


change in ht Girls on a high-calcium


change in wt Vitamin D and calcium

supplementation reduces Lappe JM., Travers-Gustafson D., Davies KM.,

change in 25 OH(D) Vitamin D and calcium

supplementation reduces Lappe JM., Travers-Gustafson D., Davies KM.,

incident cancer Calcium and vitamin d

supplementation Lappe J., Cullen D., Haynatzki G., Recker R.,

stress fractures Calcium and dairy food

intakes are inversely Larsson SC., Bergkvist L., Rutegård J., Giovannucci

Colon caner

2006200620062006200620062006200620062008200820082008200920071995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.2005200520052007200620062006200720072007200720072007200719861986198619861986200820082005200520021987198819881988


Larsson SC., Bergkvist L., Rutegård J., Giovannucci

Colorectal caner Calcium and dairy food


Distal colon Calcium and dairy food


Proximal colon Calcium and dairy food


Rectal caner Calcium and dairy food


Colon caner Calcium and dairy food


Colorectal caner Calcium and dairy food


Distal colon Calcium and dairy food


Proximal colon Calcium and dairy food


Rectal caner Magnesium, calcium,

potassium, and sodium Larsson SC., Virtanen MJ., Mars M., Männistö S.,

Also separate Magnesium, calcium,


Cerebral infarction Magnesium, calcium,


First stroke (and Magnesium, calcium,


No analysis of total Long-term dietary calcium

intake and breast cancer Larsson SC., Bergkvist L., Wolk A.

Invasive breast A prospective study of

plasma vitamin D Li H., Stampfer MJ., Hollis JB., Mucci LA., Gaziano JM.,

Prostate cancer Dietary calcium, blood

pressure and cell 1,25(OH)D [RadioreceDietary calcium, blood

pressure and cell 25(OH)D [CompetitiDietary calcium, blood

pressure and cell DBP (supine) Dietary calcium, blood

pressure and cell SBP (standing) Dietary calcium, blood

pressure and cell SBP/DBP [Standing Intakes of calcium and

vitamin D and risk of Lin J., Zhang SM., Cook NR., Manson JE., Lee IM.,

Colorectal cancer Intakes of calcium and


Distal colon Intakes of calcium and


Proximal colon Intakes of calcium and

vitamin D and breast Lin J., Manson JE., Lee IM., Cook NR., Buring JE.,

Breast cancer Calcium supplementation

for 1 y does not reduce Lorenzen JK., Mølgaard C., Michaelsen KF., Astrup A.

25(OH)D [ContinuouCalcium supplementation


height [ContinuouCalcium supplementation


body weight Preventing fractures

among older people living Lyons RA., Johansen A., Brophy S., Newcombe RG.,

First fracture Preventing fractures


Fractures (hip/wrist/fPreventing fractures


Mortality [nd:CategoSupplementation with

calcium + vitamin D Major GC., Alarie F., Doré J., Phouttama S., Tremblay

BMI [ContinuouSupplementation with


DBP [ContinuouSupplementation with


SBP [ContinuouSupplementation with


Weight [Kg:ContinVitamin D

supplementation in Mallet E., Gügi B., Brunelle P., Hénocq A., Basuyau JP.,

birth weight Vitamin D


cord blood 1,25 Vitamin D


cord blood 25(OH)D at Vitamin D


maternal 1,25 Vitamin D


maternal 25(OH)D at Effect of calcium and

vitamin D supplementation Margolis KL., Ray RM., Van Horn L., Manson JE., Allison

Hypertension [Self-Effect of calcium and

vitamin D supplementation Margolis KL., Ray RM., Van Horn L., Manson JE., Allison

Systolic BP [ContinuouDietary and serum

vitamins and minerals as Marniemi J., Alanen E., Impivaara O., Seppänen

AMI [ICD 9 codes from Dietary and serum

vitamins and minerals as Marniemi J., Alanen E., Impivaara O., Seppänen

Stroke [Same:CatCalcium, vitamin D, and

risk of adenoma Martínez ME., Marshall JR., Sampliner R., Wilkinson J.,

Adenoma recurrence Effect of calcium and

vitamin D supplementation Marya RK., Rathee S., Manrow M.

toxemia [nd:CategoEffect of vitamin D

supplementation during Marya RK., Rathee S., Dua V., Sangwan K.

crown-heel length Effect of vitamin D


gestational age Effect of vitamin D


newborn birth


Vitamin D2 dose required to rapidly increase 25OHD

Mastaglia SR., Mautalen CA., Parisi MS., Oliveri B.

25(OH)D [ContinuouVitamin D supplements

enhance weight gain and Maxwell JD., Ang L., Brooke OG., Brown IR.

birth weight Vitamin D supplements

enhance weight gain and Maxwell JD., Ang L., Brooke OG., Brown IR.

weight gain 3rd Calcium, vitamin D, dairy

products, and risk of McCullough ML., Robertson AS., Rodriguez

CRC [CategoricCalcium, vitamin D, dairy


Colorectal cancer Calcium, vitamin D, dairy


Distal colon Calcium, vitamin D, dairy


Proximal colon Calcium, vitamin D, dairy


Rectal cancer 25-hydroxyvitamin D

levels and the risk of Melamed ML., Michos ED., Post W., Astor B.

All-cause mortality 25-hydroxyvitamin D


CVD mortality 25-hydroxyvitamin D


Cancer mortality 25-hydroxyvitamin D


Infectious disease Dietary calcium and

vitamin D intakes in Mishra G., McCormack V., Kuh D., Hardy R., Stephen

Mammography Dairy products, calcium


fatal prostate Dairy products, calcium


prostate cancer Maternal 25-

hydroxyvitamin D and Morley R., Carlin JB., Pasco JA., Wark JD.

birth weight Maternal 25-


crown-heel length Maternal 25-


gestation lengthNutrient intake and


Pregnancy-induced Nutrient intake and


preeclampsia [HTN Skeletal site-dependent

response of bone mineral BMD [DXA:ContiA double-blind,

randomized, placebo-Nagpal J., Pande JN., Bhartia A.

25(OH)D [ContinuouA double-blind,


BMI (per protocol) A double-blind,


DBP [Same as A double-blind,


SBP [AutomateA double-blind,


Weight (ITT) Supplements of 20


Serum 25(OH)D Serum vitamin D

metabolite levels and the Nomura AM., Stemmermann GN., Lee J.,

prostate cancer Calcium and vitamin D

intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.

Colorectal adenoma Calcium and vitamin D

intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.

Distal colon Diet during pregnancy and

risk of preeclampsia or Oken E., Ning Y., Rifas-Shiman SL., Rich-Edwards

gestational HTNDiet during pregnancy and

risk of preeclampsia or Oken E., Ning Y., Rifas-Shiman SL., Rich-Edwards

preeclampsia [BP Plasma vitamin D and risk

of colorectal cancer: the Otani T., Iwasaki M., Sasazuki S., Inoue M.,

Colon cancer Plasma vitamin D and risk


Colorectal cancer Plasma vitamin D and risk


Rectal cancer Calcium and vitamin D

intake and risk of Park SY., Murphy SP., Wilkens LR., Nomura AM.,

Colorectal cancer Calcium, dairy foods, and

risk of incident and fatal Park Y., Mitrou PN., Kipnis V., Hollenbeck A.,

incident prostate Calcium, vitamin D, and

dairy product intake and Park SY., Murphy SP., Wilkens LR., Stram DO.,

Prostate cancer Dairy food, calcium, and

risk of cancer in the NIH-Park Y., Leitzmann MF., Subar AF., Hollenbeck A.,

All cancers [Identified Dairy food, calcium, and


Bladder cancer Dairy food, calcium, and


Brain and other Dairy food, calcium, and


Brain cancer Dairy food, calcium, and


Breast cancer Dairy food, calcium, and


Colorectal cancer Dairy food, calcium, and


Digestive system Dairy food, calcium, and


Endocrine system Dairy food, calcium, and


Endometrial cancer Dairy food, calcium, and


Esophageal cancer

200920092009200920092009200920092009200920092009200920092009200920012001200119992000200020002000200020052005200520052005200320071997200419991995199519952002200620062006200619931993199320082008

Dairy food, calcium, and risk of cancer in the NIH-

Park Y., Leitzmann MF., Subar AF., Hollenbeck A.,

Head and neck Dairy food, calcium, and


Kidney cancer Dairy food, calcium, and


Leukemia [The same Dairy food, calcium, and


Liver cancer Dairy food, calcium, and


Lung cancer Dairy food, calcium, and


Myeloma [The same Dairy food, calcium, and


Non-Hodgkin Dairy food, calcium, and


Others [A combined Dairy food, calcium, and


Ovarian cancer Dairy food, calcium, and


Pancreatic cancer Dairy food, calcium, and


Reproductive system Dairy food, calcium, and


Respiratory system Dairy food, calcium, and


Stomach cancer Dairy food, calcium, and


Thyroid cancer Dairy food, calcium, and


Urinary system Dairy food, calcium, and


Women [A Effects of a short-term

vitamin D(3) and calcium Pfeifer M., Begerow B., Minne HW., Nachtigall D.,

25(OH)D [ContinuouEffects of a short-term


DBP [Same as Effects of a short-term


SBP [Measured Diet and risk of colorectal

cancer in a cohort of Pietinen P., Malila N., Virtanen M., Hartman TJ.,

Colon cancer or Plasma 1,25-dihydroxy-

and 25-hydroxyvitamin D Platz EA., Hankinson SE., Hollis BW., Colditz GA.,

Distal colon Plasma 1,25-dihydroxy-


Distal colorectal Plasma 1,25-dihydroxy-


Rectal adenoma Plasma 1,25-dihydroxy-


high-risk distal colon Plasma 1,25-dihydroxy-


low-risk (distal) Effects of calcium

supplementation on body Reid IR., Horne A., Mason B., Ames R., Bava U.,

BMI [ContinuouEffects of calcium


DBP [ContinuouEffects of calcium


SBP [ContinuouEffects of calcium


BP [SBP, DBP]Effects of calcium


Weight [Kg, Calcium, dairy products,

and risk of prostate cancer Rodriguez C., McCullough ML., Mondul AM., Jacobs

Prostate cancer Meat and dairy

consumption and Rohrmann S., Platz EA., Kavanaugh CJ., Thuita L.,

incident prostate Prospective evaluation of

dietary and other Ross RK., Yuan JM., Henderson BE., Park J.,

Fatal stroke Serum parathyroid

hormone is associated Sambrook PN., Chen JS., March LM., Cameron ID.,

Total mortality Animal products, calcium

and protein and prostate Schuurman AG., van den Brandt PA., Dorant E.,

Prostate cancer Effect of winter oral

vitamin D3 Scragg R., Khaw KT., Murphy S.

25(OH)D [As Effect of winter oral


DBP [BP was Effect of winter oral


SBP [BP was Intake of dairy products,

calcium, and vitamin d and Shin MH., Holmes MD., Hankinson SE., Wu K.,

Breast cancer Dietary intake of calcium,

fiber and other Shin A., Li H., Shu XO., Yang G., Gao YT., Zheng

Colon cancerDietary intake of calcium,


Colorectal cancer Dietary intake of calcium,


Rectal cancerVitamin D intake and the

risk for pancreatic cancer Skinner HG., Michaud DS., Giovannucci E., Willett

Pancreatic cancer Calcium intake and 28-

year gastro-intestinal Slob IC., Lambregts JL., Schuit AJ., Kok FJ.

All-cause mortality Calcium intake and 28-


Cancer mortality Calcium intake and 28-


Gastrointestinal Supplementation with

cholecalciferol does not Sneve M., Figenschau Y., Jorde R.

BMI [ContinuouSupplementation with

cholecalciferol does not Sneve M., Figenschau Y., Jorde R.

weight [Continuou

200820092006199719971997199719972002200220022002200219872003200320032003200320032003200320032003200320032003200320032003200320052006200620062006200820082008200819861986200720062006200620062006

Supplementation with cholecalciferol does not

Sneve M., Figenschau Y., Jorde R.

Serum 25(OH)D Serum vitamin D and risk

of pancreatic cancer in the Stolzenberg-Solomon RZ., Hayes RB., Horst RL.,

Pancreatic cancer A prospective nested case-

control study of vitamin D Stolzenberg-Solomon RZ., Vieth R., Azad A., Pietinen

Pancreatic cancer Serum levels of vitamin D

metabolites and the Tangrea J., Helzlsouer K., Pietinen P., Taylor P., Hollis

Colon cancer Serum levels of vitamin D


Colon cancer Serum levels of vitamin D


Colorectal cancer Serum levels of vitamin D


Rectal cancer Serum levels of vitamin D


Rectal cancer Dietary calcium and

vitamin D intake and risk Terry P., Baron JA., Bergkvist L., Holmberg L.,

Colon cancer Dietary calcium and


Colorectal cancer Dietary calcium and


Distal colon Dietary calcium and


Proximal colon Dietary calcium and


Rectal cancer Dietary calcium intake and

blood pressure in Thomsen K., Nilas L., Christiansen C.

Bodyweight [Change Effect of four monthly oral

vitamin D3 Trivedi DP., Doll R., Khaw KT.

All cancers incidence Effect of four monthly oral


All cancers mortality Effect of four monthly oral


All cause mortality Effect of four monthly oral


Breast cancer Effect of four monthly oral


Breast cancer Effect of four monthly oral


Cardiovascular Effect of four monthly oral


Cardiovascular Effect of four monthly oral


Cerebrovascular Effect of four monthly oral


Cerebrovascular Effect of four monthly oral


Colorectal cancer Effect of four monthly oral


Colorectal caner Effect of four monthly oral


Falls incidence Effect of four monthly oral


Ischemic heart Effect of four monthly oral


Ischemic heart Effect of four monthly oral


Respira-ry [CategoricEffect of four monthly oral


Respiratory cancer Effect of four monthly oral


Respiratory cancer Dairy, calcium, and

vitamin D intakes and Tseng M., Breslow RA., Graubard BI., Ziegler RG.

Prostate cancer Dietary intake of calcium

in relation to mortality Umesawa M., Iso H., Date C., Yamamoto A.,

Coronary heart Dietary intake of calcium


Total CVD mortality Dietary intake of calcium


Total stroke Dietary intake of calcium


specific stroke data Dietary calcium intake and

risks of stroke, its Umesawa M., Iso H., Ishihara J., Saito I., Kokubo

CHD [CategoricDietary calcium intake and


Coronary heart Dietary calcium intake and


Fatal stroke Dietary calcium intake and


Stroke incidence Oral calcium and blood

pressure: a controlled van Beresteyn EC., Schaafsma G., de Waard

BMI [ContinuouOral calcium and blood

pressure: a controlled van Beresteyn EC., Schaafsma G., de Waard

Body weight Childhood dairy intake and

adult cancer risk: 65-y van der Pols JC., Bain C., Gunnell D., Smith GD.,

Colorectal cancer Low serum concentrations

of 25-hydroxyvitamin D in Visser M., Deeg DJ., Puts MT., Seidell JC., Lips P.

mortality [by death Calcium plus vitamin D

supplementation and the Wactawski-Wende J., Kotchen JM., Anderson GL.,

(Invasive) colon Calcium plus vitamin D


(Invasive) colorectal Calcium plus vitamin D


(invasive) rectal Calcium plus vitamin D


All cause mortality

2006200620062006200620062006200620062006200620081996199619961996200819971997199719872002200220022007200720072007200719951995 in DBP199519982008200820082008


Wactawski-Wende J., Kotchen JM., Anderson GL.,

Cancer related Calcium plus vitamin D


Death from colorectal Calcium plus vitamin D


Intestinal polyps Calcium plus vitamin D


Kidney stone Calcium plus vitamin D


Total cancer High-dose vitamin D3

supplementation in a Wagner CL., Hulsey TC., Fanning D., Ebeling M.,

25(OH)D level in High-dose vitamin D3


25(OH)D level in High-dose vitamin D3


anti-rachitic High-dose vitamin D3


at 2 mo [ContinuouHigh-dose vitamin D3


infant weight and High-dose vitamin D3


vit D3 level in mom Vitamin D deficiency and

risk of cardiovascular Wang TJ., Pencina MJ., Booth SL., Jacques PF.,

First cardiovascEffect of longterm placebo


Calcium balance Effect of longterm placebo


PI [Change in PI% of Effect of longterm placebo


PI [Change in PI% of Effect of longterm placebo


PI [Change in curve of Is ischemic stroke risk

related to folate status or Weng LC., Yeh WT., Bai CH., Chen HJ., Chuang SY.,

stroke [Self-Efficacy of

nonpharmacologic Whelton PK., Kumanyika SK., Cook NR., Cutler JA.,

DBP [ContinuouEfficacy of


SBP [ContinuouEfficacy of


Change in SBP/DBPAlcohol, physical activity

and other risk factors for Wu AH., Paganini-Hill A., Ross RK., Henderson BE.

Colorectal cancer Calcium intake and risk of

colon cancer in women Wu K., Willett WC., Fuchs CS., Colditz GA.,

Distal (left sided) Calcium intake and risk of


Primary adenocarciCalcium intake and risk of


Proximal (right A nested case control

study of plasma 25-Wu K., Feskanich D., Fuchs CS., Willett WC., Hollis

Distal colon A nested case control


Colon cancer A nested case control


Colorectal cancer A nested case control


Proximal colon A nested case control


Rectal cancer Lack of blood pressure


BMI [ContinuouLack of blood pressure



in SBP [ContinuouA prospective cohort study

of intake of calcium, Zheng W., Anderson KE., Kushi LH., Sellers TA.,

Rectal cancer Effects of calcium and

vitamin D supplementation Zhu K., Devine A., Dick IM., Wilson SG., Prince RL.

25(OH)D [Measured Effects of calcium and

vitamin D supplementation Zhu K., Devine A., Dick IM., Wilson SG., Prince RL.

BMD [Measured Randomized controlled


25(OH)D [ContinuouRandomized controlled


BMD [Hip and total

Unit(s) Type NotesN/A (years) Categorical secondary

nd N/A (years) Categorical secondarynd N/A (years) Categorical Nd

N/A (years) CategoricalN/A (years) Categorical12 (years) Categorical 112 (years) Categorical 212 (years) Categorical 1

kg N/A (years) Continuous 22 (years) Categorical

Continuous primaryContinuous primaryContinuous primary

1 CategoricalCategorical

N/A (years) 1N/A (years) Stroke Categorical

Secondary CategoricalSecondary Categorical

N/A (years) Categorical PrimaryN/A (years) Secondary

nmol/l N/A (years) Continuous PrimaryAll cause N/A (years) Continuous secondary

nmol/L N/A (years) Continuous Primary30 (weeks) Categorical primaryN/A (years) CategoricalN/A (years)N/A (years) CategoricalN/A (years) CategoricalN/A (years) Categorical

ug/L N/A (years) Continuous ndmg/cm2 N/A (years) Continuous ndkg N/A (years) Continuous 2

N/A (years) CategoricalN/A (years) CategoricalN/A (years) Categorical

Counts N/A (years) Continuous SecondaryKg N/A (years) Continuous Secondaryseconds N/A (years) Continuous Secondary

N/A (years) secondaryN/A (years) Categorical secondary

kg N/A (years) Continuous primaryN/A (years) secondary

m N/A (years) Continuousm N/A (years) Continuous

N/A (years) Fall Categorical primaryN/A (years) Fracture Categorical primary

Description

Timepoint(s)

Subgroup(s)Gleason

sum >=7 All ParticipantAll ParticipantAll ParticipantAll ParticipantAll ParticipantIncluding

sudden All ParticipantImplied

combinatioAll ParticipantSelf-

reporting All ParticipantChange in

kg/yrAll ParticipantPhysician

diagnosis All ParticipantEnter a

numeric All ParticipantDXA, whole

body, or Enter a numeric

All ParticipantDXA, whole

body, or Enter a numeric

All ParticipantEnter a

numeric All Participant

self-reported Enter a

numeric All ParticipantFatal or

nonfatal All Participantnot

extracted Enter a numeric

All Participant

Incident cases were Enter a

numeric All Participant

Prostate-specific Risk of

developing All ParticipantRisk of

developing All ParticipantChanges

from All ParticipantAll ParticipantAll Participantgestational

HTN & All Participantcomposite

All Participant

1 (this analysis; 2 Family,

hospital, All Participant

1 (this analysis; 2 Standard

criteria All Participant





1 (this analysis; 2 Measured

at baseline All ParticipantDEXA of

the femur All ParticipantAll ParticipantState

Health All Participant

Not explicitly All

ParticipantDiagnosed 1980-

All Participant

Primary (in post hoc Conducted

if the Chair stands Two

measuremGrip strength The timed

walk Timed walk (year 2), No assay

informatioNo subgroups Fall free

survival Fall free survival Isometric

quadriceps Right quadriceps Endurance

(The No subgroups Timed up and goTwelve minutes Defined as

the patient Any fracture

Kg N/A (years)N/A (years) Categorical SecondaryN/A (years) Categorical

g/cm2 N/A (years) areal BMD ContinuousN/A (years) primary

g N/A (years) Continuouspmol/L N/A (years) Continuous

N/A (years) SecondaryKg N/A (years) Continuous Primary

N/A (years) SecondaryN/A (years) PrimaryN/A (years) SecondaryN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical 2N/A (years) Categorical 1

Kg/m2 N/A (years) Continuous ndKg N/A (years) Continuous ndng/ml N/A (years) Continuouskg N/A (years) Continuous

N/A (years) PrimaryKg N/A (years) Continuous Primary

N/A (years) ContinuousN/A (years) Continuous

cm N/A (years) ContinuousN/A (years) Continuous primaryN/A (years) Continuous primary

nd N/A (years) ndN/A (years) Categorical nd

nd N/A (years) ndnd N/A (years) nd

N/A (years) ndN/A (years) NdN/A (years) CategoricalN/A (years)N/A (years) Categorical PrimaryN/A (years) Continuous SecondaryN/A (years) Continuous PrimaryN/A (years) Continuous SecondaryN/A (years) Continuous SecondaryN/A (years) Continuous SecondaryN/A (years) Continuous SecondaryN/A (years) Continuous SecondaryN/A (years) Continuous SecondaryN/A (years) CategoricalN/A (years)

cm N/A (years) ContinuousKg N/A (years) Continuous

No subgroups

2 (1 for this article)Requested

permission Prostate cancerConfirmed

by both Invasive breast

Not clear. Most likely

by dual-energy X-

All Participantchange in BMC (ITT 25(OH)D, 1,25(OH)DChange in

25(OH)D No subgroups Change in

weight in Body weightDeath

recordAll ParticipantInvasive

adenocarciAll ParticipantGleason

gradeAll Participantnd (only

for patients Adenomas recurrencend (only

for patients Survival, SurvivalSBP 160

or DBP 95 All ParticipantHTN

medication All ParticipantBMI, BMI, BMITo the

nearest 0.5 Weight, Weight, All ParticipantAll ParticipantAll ParticipantTotal body BMCAll ParticipantAll ParticipantAll ParticipantLength gain in weight gain in All ParticipantReported

by a All ParticipantAll ParticipantAll ParticipantSame as

aboveAll ParticipantSelf

reports, All ParticipantSame as

above (not Colorectal cancer Subject

reporting No subgroups

1 (for this post hoc Self-

reported All ParticipantBased on

ICD-10 All ParticipantBased on







ICD-10 All ParticipantIncident

breast Incident breast

Primary outcomeNorwegian

cancer No subgroups

Primary (only 9 mo

length9 mo weight

N/A (years) Categoricalcm N/A (years) Continuous primaryKg N/A (years) Continuous

N/A (years) Categorical NdN/A (years) Categorical ndN/A (years) Categorical nd

mm Hg N/A (years) DBP Continuousmm Hg N/A (years) SBP Continuous

N/A (years) 2Kg Kg N/A (years) Weight Continuous 2

N/A (years) Categorical ndN/A (years) Categorical Primary

nmol/L N/A (years) Continuous secondarynmol/L N/A (years) Continuous primarynmol/L N/A (years) Continuous primary

N/A (years) Categorical ndN/A (years) Categorical nd

Kg N/A (years) Continuous Primarymm Hg N/A (years) DBP Continuousmm Hg N/A (years) SBP Continuous

N/A (years) 2N/A (years) primary

kg N/A (years) Continuous secondaryN/A (years)

nd N/A (years) Categorical secondaryN/A (years)N/A (years)N/A (years) CategoricalN/A (years)N/A (years) primaryN/A (years)

Kg/m2 N/A (years) BMI Continuous ndkg N/A (years) Weight Continuous nd

N/A (years) Categorical ndN/A (years) CategoricalN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) ndN/A (years) Categorical ndN/A (years) Categorical primaryN/A (years) nd

kg/m2 N/A (years) BMI Continuous secondarycm N/A (years) ht Continuouskg N/A (years) wt Continuous

N/A (years) ContinuousN/A (years) Categorical secondaryN/A (years) Categorical primaryN/A (years) nd

modified UK

atopic eczema at birth lengthbirth weightMedical

records Total prostate Medical

and Colorectal cancerICD-8

153.0-All Participant

No subgroups

Advanced lesions

Advanced adenomas, For each

colonoscopAll adenomas, sum of D2

and D3change in total change in 25(OH)D2 change in 25(OH)D3 Subjects

had Advanced adenomas, Ascertaine

d by Recurrent adenomasChange in

bodyweighBody weight

No subgroups 25(OH)D/

vitD doseNo subgroups Change in

kg over 30 Body weightConfirmed

through No subgroups

Only reported Prostate

cancer, Finish cancer

No subgroups

Not explicitly Finish

cancer No subgroups

Not explicitly Finish

cancer Colorectal cancer

Not explicitly No

subgroups No subgroups No subgroups

Analyzed by a Record linkage to

Colorectal cancer Self

reports (in Colorectal cancer

Not explicitly Response

to the Colon cancer Mostly

diagnosed Colorectal cancerComplete

colonoscopNo subgroups Self

reported Breast cancer, self-

reported of prostate cancer, Active

patient No subgroups

change in 25 OH(D) from

medical incident cancer Stress

fractures Stress fracture National

Swedish No subgroups

N/A (years) Categorical ndN/A (years) Categorical ndN/A (years) ndN/A (years) Categorical ndN/A (years)N/A (years) CategoricalN/A (years) CategoricalN/A (years)N/A (years) CategoricalN/A (years)N/A (years) CategoricalN/A (years) 1N/A (years)N/A (years) Categorical PrimaryN/A (years) Categorical secondary

pg/mL N/A (years) 1,25(OH)D Continuousng/mL N/A (years) 25(OH)D Continuous 2mm Hg N/A (years) Continuousmm Hg N/A (years) Continuous

N/A (years) 2N/A (years) ndN/A (years) Categorical ndN/A (years) ndN/A (years) Categorical Primary

mmol/L N/A (years) Continuous secondarycm N/A (years) ContinuousKg N/A (years) Continuous primary

N/A (years) Categorical PrimaryN/A (years) Secondary

nd N/A (years) mortality Categorical SecondaryKg/m2 N/A (years) BMI Continuous 2mmHg N/A (years) DBP Continuous 2mmHg N/A (years) SBP Continuous 2

Kg Kg N/A (years) Weight Continuous 2g N/A (years) Continuous secondarypmol/L N/A (years) Continuous

N/A (years)N/A (years) primary

nmol/L N/A (years) Continuous primaryN/A (years) Categorical primary

mmHg N/A (years) ContinuousN/A (years) Categorical 1

Same N/A (years) CategoricalN/A (years) Categorical primary

nd N/A (years) toxemia Categorical primarycm N/A (years) Categorical secondarywk N/A (years) ContinuousKg N/A (years) Continuous primary

National Swedish

Colorectal cancer National

Swedish Colon cancer National

Swedish No subgroups National

Swedish Rectal cancer National


Not explicitly National

Swedish Colorectal cancer


Swedish Colon cancer




Swedish Rectal cancer

Not explicitly No

subgroups Cerebral infarctionHospital

discharge No subgroups No subgroups Linkage

with Invasive breast Tumor

Gleason Total prostate Radiorecep

tor assay Competitive protein DBP

(supine)SBP (standing), Standing

and supineNo subgroups Follow-up

questionnaNo subgroups Not fully

defined Colorectal cancer Not fully

defined No subgroups Incident

cases of Invasive breast 25(OH)D Δ in medium height Δ in medium weight Δ in medium Confirmed

by First fracture Confirmed

by No subgroups

birth weightcord 25(OH)D, No subgroups No subgroups maternal 25(OH)D at Self-report

of HypertensionSystolic BP, Diastolic ICD 9

codes from AMI, AMI, AMIStroke, Stroke, One or

more Adenoma recurrence,

crown-heel lengthgestational agenewborn birth

nmol/L N/A (years) Continuous primaryg N/A (years) Continuous secondary

N/A (years) primaryN/A (years) CRC CategoricalN/A (years) primaryN/A (years)N/A (years)N/A (years)N/A (years) primaryN/A (years) PrimaryN/A (years) PrimaryN/A (years) primaryN/A (years) Categorical NDN/A (years) CategoricalN/A (years) Categorical primary

g N/A (years) Continuous primarycm N/A (years) Continuous

N/A (years)N/A (years) CategoricalN/A (years) Categorical primary

DXA g/cm2 N/A (years) Continuous primarynmol/L N/A (years) Continuous nd

N/A (years) ContinuousmmHg N/A (years) Continuous 2mmHg N/A (years) Continuous 2kg/m2 N/A (years) Continuousnmol/L N/A (years) 25(OH)D Continuous Primary

N/A (years) Categorical primaryN/A (years) Adenoma Categorical ndN/A (years) CategoricalN/A (years)N/A (years) primaryN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical primaryN/A (years) Categorical ndN/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***

25(OH)D at 2 mo, maternal weight No subgroups

Confirmed incident

No subgroups Cancer at

descending No subgroups Cancer at

cecum to No subgroups Cancer at

rectum No subgroups Linked

National No subgroups Cause-

specific No subgroups Including

all No subgroups Including

deaths No subgroups Ratio of

the Mammographic All ParticipantFinnish

Cancer All Participantbirth weightcrown-heel lengthNo subgroups Pregnancy-induced HTN (DBP

90 mm) preeclampsiaTotal body BMD, Total 25(OH)D (ITT), BMI (per protocol)Same as

SBPDBP (ITT), DBP (per Automated

OMRON SBP (ITT analysis), Weight (ITT),

biopsy or surgical

prostate cancerReviewed

the Distal colon No subgroups BP

>140/90 & No subgroups See above

(ICD180-Men, WomenAdenocarci

noma Men, WomenSee above

(ICD199 Men, WomenIdentified

by means Colorectal cancer 8 state

cancer total prostate Identified

by linkage Prostate cancer, Identified

thorough a No subgroups The same

as all No subgroups A

combined No subgroups The same

as all No subgroups The same



combined No subgroups A



as all No subgroups

N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***N/A (years) Nd***

nmol/L N/A (years) 25(OH)D ContinuousmmHg N/A (years) DBP Continuous 1mmHg N/A (years) SBP Continuous 1

N/A (years) CategoricalN/A (years) CategoricalN/A (years) Categorical ndN/A (years) CategoricalN/A (years) CategoricalN/A (years) Categorical

kg/m2 N/A (years) BMI Continuousmm Hg N/A (years) DBP Continuousmm Hg N/A (years) SBP Continuous

SBP, DBP N/A (years) 2Kg, BMI Kg N/A (years) Weight Continuous 2

N/A (years) Categorical NdN/A (years) Categorical primaryN/A (years) Categorical 1N/A (years)N/A (years) nd

ng/mL N/A (years) 25(OH)D Continuous 2N/A (years) DBP Continuous 1

mmHg N/A (years) SBP Continuous 1N/A (years) ndN/A (years) secondaryN/A (years) Categorical primaryN/A (years) secondaryN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) nd

Kg/m2 N/A (years) BMI Continuous 2kg N/A (years) weight Continuous 1

The same as all

No subgroups The same


as NHLNo subgroups The same



as NHLNo subgroups Identified

through No subgroups A









combined No subgroups

Same as SBPMeasured after at Incident cases of

Colorectal cancer

Secondary outcomeAdenomat

ous polyps All ParticipantAdenomat

ous polyps All ParticipantAdenomat

ous polyps All ParticipantLarge (1

cm or All ParticipantSmall (<1

cm), All Participant

No subgroups

Incident cases

Prostate cancerCancer

Registry; incident prostate Fatal strokeMortality

and cause No subgroups

Secondary (assumed Computeri

zed record No subgroups As

measured BP was measured BP was measured Medical records

No subgroups No subgroups Cohort

members Colorectal cancer, No subgroups Self-

reported Pancreatic cancer, The

residence All cause mortality – The

residence Gastrointestinal The

residence No subgroups

nmol/L N/A (years) Continuous 2N/A (years) CategoricalN/A (years) Categorical CancerN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) secondaryN/A (years) primaryN/A (years) secondaryN/A (years) secondaryN/A (years) secondary

Kg N/A (years) Continuous ndN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) SecondaryN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) SecondaryN/A (years) SecondaryN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) SecondaryN/A (years) Respira-ry CategoricalN/A (years) Categorical SecondaryN/A (years) SecondaryN/A (years) NdN/A (years) 2N/A (years) 2N/A (years) 1N/A (years)N/A (years) CHD CategoricalN/A (years) 2N/A (years) Categorical 1N/A (years) 1

Kg/m2 N/A (years) BMI ContinuousKg N/A (years) Continuous Secondary

N/A (years) ndN/A (years) Categorical primaryN/A (years) ndN/A (years)N/A (years) nd

nd N/A (years) Categorical nd

Serum 25(OH)DVital status

of cohort Pancreatic cancerodds ratios

(OR) for pancreatic cancer, All ParticipantDiagnosis

of primary All ParticipantDiagnosis

of primary All ParticipantAll ParticipantDiagnosis

of primary All ParticipantCancer

occurring No subgroups Matching

two No subgroups Cancer

occurring No subgroups Cancer

occurring No subgroups Cancer

occurring No subgroups Change in

kg/yrBodyweight changesame as

aboveAll Causes, All same as

aboveNo subgroups Death

certificate No subgroups same as

aboveBreast, Cancer same as

aboveNo subgroups Death

certificate No subgroups same as

aboveNo subgroups same as

aboveCardiovascular same as


aboveColorectal, Colorectal, same as


aboveSelf Reported same as


aboveNo subgroups

same as above

Respiratory, same as

aboveNo subgroups Confirmati

on through No subgroups Death

certificates No subgroups Death

certificates No subgroups Death

certificates No subgroups not

extractedNo subgroups

MI, sudden cardiac

No subgroups Death

certificates Total strokeParticipant

reporting No subgroups

Body weight in

Body weightDerived

from the No subgroups by death

certificatemortality, mortality, Excluded

in situ and No subgroups Verified in

a blinded No subgroups

Secondary (primary: Excluded

in situ and No subgroups All cause mortality

N/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) ndN/A (years)N/A (years) primaryN/A (years)N/A (years) ContinuousN/A (years)

ng/mL N/A (years) ContinuousN/A (years) Categorical Primary

% change N/A (years) Continuous UnlcearN/A (years) Unlcear

% change N/A (years) Continuous UnlcearN/A (years) UnlcearN/A (years) stroke Categorical nd

mm Hg N/A (years) DBP Continuousmm Hg N/A (years) SBP Continuous

N/A (years) 1N/A (years) ndN/A (years) Categorical primaryN/A (years) Categorical primaryN/A (years) Categorical primaryN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical ndN/A (years) Categorical nd

kg/m2 N/A (years) Continuous ndN/A (years) 1

mmHg N/A (years) Continuous 1N/A (years) Categorical secondary

nmol/liter Continuous Secondarymg/cm2 Continuous Primarynmol/L N/A (years) Continuous Secondarymg/cm2 N/A (years) Continuous primary

Kidney stone

Invasive colorectal Death from

colorectal Death from colorectal Intestinal

polyps Intestinal PolypKidney

stone Kidney stone (UL)Intestinal

polyps No subgroups No subgroups No subgroups vit D3 and

25 (OH)D No subgroups at 2 mo, at 3 mo, at 4 No subgroups mom 25 (OH)D at 1 MI,

coronary CV event, CV eventTotal fecal

calcium Total fecal calcium, Change in

PI% of all No subgroups Change in

PI% of PI (total), PI (highest Change in

curve of PINo subgroups Self-

reported

No subgroups Pathologic

al No subgroups Colon

cancer All ParticipantReported

as All ParticipantColon

cancer All ParticipantAll ParticipantAll ParticipantThe vast

majority of All ParticipantAll ParticipantAll ParticipantAll ParticipantAll ParticipantSBP in white State

Health All ParticipantMeasured

by 1 (years), 3 (years), 5

All ParticipantMeasured

at the hip 12 (months),

All ParticipantAll ParticipantHip and

total body. All Participant

Study ID:EF ID Creator Create Date PMID6304:194 admin Aug 18, 2013 Sep 5, 2014 185059676305:194 admin Aug 18, 2013 Sep 5, 2014 110758746306:194 admin Aug 18, 2013 Sep 5, 2014 126632776307:194 admin Aug 18, 2013 Sep 5, 2014 78928826308:194 admin Aug 18, 2013 Sep 5, 2014 162804276309:194 admin Aug 18, 2013 Sep 5, 2014 182086366311:194 admin Aug 18, 2013 Sep 5, 2014 13303606312:194 admin Aug 18, 2013 Sep 5, 2014 86211986313:194 admin Aug 18, 2013 Sep 5, 2014 97435116314:194 admin Aug 18, 2013 Sep 5, 2014 157673346315:194 admin Aug 18, 2013 Sep 5, 2014 161034506316:194 admin Aug 18, 2013 Sep 5, 2014 179650376317:194 admin Aug 18, 2013 Sep 5, 2014 186895596318:194 admin Aug 18, 2013 Sep 5, 2014 175359856319:194 admin Aug 18, 2013 Sep 5, 2014 181983946320:194 admin Aug 18, 2013 Sep 5, 2014 172438666321:194 admin Aug 18, 2013 Sep 5, 2014 188427716322:194 admin Aug 18, 2013 Sep 5, 2014 83334126323:194 admin Aug 18, 2013 Sep 5, 2014 99219606325:194 admin Aug 18, 2013 Sep 5, 2014 76128036326:194 admin Aug 18, 2013 Sep 5, 2014 187553196327:194 admin Aug 18, 2013 Sep 5, 2014 167979036328:194 admin Aug 18, 2013 Sep 5, 2014 176564206329:194 admin Aug 18, 2013 Sep 5, 2014 175025306330:194 admin Aug 18, 2013 Sep 5, 2014 115666566331:194 admin Aug 18, 2013 Sep 5, 2014 190016016333:194 admin Aug 18, 2013 Sep 5, 2014 162804476334:194 admin Aug 18, 2013 Sep 5, 2014 152130386335:194 admin Aug 18, 2013 Sep 5, 2014 82200926336:194 admin Aug 18, 2013 Sep 5, 2014 86824536337:194 admin Aug 18, 2013 Sep 5, 2014 88906616338:194 admin Aug 18, 2013 Sep 5, 2014 171895526339:194 admin Aug 18, 2013 Sep 5, 2014 162782626340:194 admin Aug 18, 2013 Sep 5, 2014 80781156341:194 admin Aug 18, 2013 Sep 5, 2014 153424526342:194 admin Aug 18, 2013 Sep 5, 2014 156684856343:194 admin Aug 18, 2013 Nov 6, 2013 19376626344:194 admin Aug 18, 2013 Sep 5, 2014 173720316345:194 admin Aug 18, 2013 Sep 5, 2014 188386236346:194 admin Aug 18, 2013 Sep 5, 2014 179715266347:194 admin Aug 18, 2013 Sep 5, 2014 183814726348:194 admin Aug 18, 2013 Sep 5, 2014 90612756349:194 admin Aug 18, 2013 Sep 5, 2014 173110576350:194 admin Aug 18, 2013 Sep 5, 2014 88502736351:194 admin Aug 18, 2013 Sep 5, 2014 28573646352:194 admin Aug 18, 2013 Sep 5, 2014 25729006353:194 admin Aug 18, 2013 Sep 5, 2014 7493659

Last Updated

6356:194 admin Aug 18, 2013 Sep 5, 2014 146522386357:194 admin Aug 18, 2013 Sep 5, 2014 172279966358:194 admin Aug 18, 2013 Sep 5, 2014 105113296359:194 admin Aug 18, 2013 Sep 5, 2014 156712226360:194 admin Aug 18, 2013 Sep 5, 2014 162865196361:194 admin Aug 18, 2013 Sep 5, 2014 145539576362:194 admin Aug 18, 2013 Sep 5, 2014 124993436363:194 admin Aug 18, 2013 Sep 5, 2014 94050296364:194 admin Aug 18, 2013 Sep 5, 2014 39462956367:194 admin Aug 18, 2013 Nov 6, 2013 104714226368:194 admin Aug 18, 2013 Nov 6, 2013 104714226369:194 admin Aug 18, 2013 Sep 5, 2014 152258336370:194 admin Aug 18, 2013 Sep 5, 2014 116417506371:194 admin Aug 18, 2013 Sep 5, 2014 174421306372:194 admin Aug 18, 2013 Sep 5, 2014 82014446373:194 admin Aug 18, 2013 Sep 5, 2014 175528806374:194 admin Aug 18, 2013 Sep 5, 2014 82055386375:194 admin Aug 18, 2013 Sep 5, 2014 93438376376:194 admin Aug 18, 2013 Sep 5, 2014 86107046377:194 admin Aug 18, 2013 Sep 5, 2014 158805326378:194 admin Aug 18, 2013 Sep 5, 2014 175361916379:194 admin Aug 18, 2013 Sep 5, 2014 171064376380:194 admin Aug 18, 2013 Sep 5, 2014 183980336381:194 admin Aug 18, 2013 Sep 5, 2014 192211906382:194 admin Aug 18, 2013 Sep 5, 2014 153541506383:194 admin Aug 18, 2013 Sep 5, 2014 175566976384:194 admin Aug 18, 2013 Sep 5, 2014 184333056385:194 admin Aug 18, 2013 Sep 5, 2014 165229156386:194 admin Aug 18, 2013 Sep 5, 2014 165229156387:194 admin Aug 18, 2013 Sep 5, 2014 183322896388:194 admin Aug 18, 2013 Sep 5, 2014 190565696389:194 admin Aug 18, 2013 Sep 5, 2014 173886676390:194 admin Aug 18, 2013 Sep 5, 2014 85579656391:194 admin Aug 18, 2013 Sep 5, 2014 158002686392:194 admin Aug 18, 2013 Sep 5, 2014 175332086393:194 admin Aug 18, 2013 Sep 5, 2014 164000446394:194 admin Aug 18, 2013 Sep 5, 2014 174739116395:194 admin Aug 18, 2013 Sep 5, 2014 172091776396:194 admin Aug 18, 2013 Sep 5, 2014 37555176397:194 admin Aug 18, 2013 Sep 5, 2014 188246626398:194 admin Aug 18, 2013 Sep 5, 2014 159554676399:194 admin Aug 18, 2013 Sep 5, 2014 120201026401:194 admin Aug 18, 2013 Sep 5, 2014 36232606402:194 admin Aug 18, 2013 Sep 5, 2014 32436096403:194 admin Aug 18, 2013 Sep 5, 2014 163915876404:194 admin Aug 18, 2013 Sep 5, 2014 67930586405:194 admin Aug 18, 2013 Sep 5, 2014 127087196406:194 admin Aug 18, 2013 Sep 5, 2014 16365007

6407:194 admin Aug 18, 2013 Sep 5, 2014 186950766408:194 admin Aug 18, 2013 Sep 5, 2014 188278116409:194 admin Aug 18, 2013 Sep 5, 2014 171064376410:194 admin Aug 18, 2013 Sep 5, 2014 163526846411:194 admin Aug 18, 2013 Sep 5, 2014 112624666412:194 admin Aug 18, 2013 Sep 5, 2014 171818906413:194 admin Aug 18, 2013 Sep 5, 2014 191257566414:194 admin Aug 18, 2013 Sep 5, 2014 191582266415:194 admin Aug 18, 2013 Sep 5, 2014 97941756416:194 admin Aug 18, 2013 Sep 5, 2014 173796166417:194 admin Aug 18, 2013 Sep 5, 2014 175219216418:194 admin Aug 18, 2013 Sep 5, 2014 176222446419:194 admin Aug 18, 2013 Sep 5, 2014 172153806420:194 admin Aug 18, 2013 Sep 5, 2014 180000206421:194 admin Aug 18, 2013 Sep 5, 2014 179252836422:194 admin Aug 18, 2013 Sep 5, 2014 192377246423:194 admin Aug 18, 2013 Sep 5, 2014 112975966424:194 admin Aug 18, 2013 Sep 5, 2014 105306086425:194 admin Aug 18, 2013 Sep 5, 2014 110457886428:194 admin Aug 18, 2013 Sep 5, 2014 158271036429:194 admin Aug 18, 2013 Sep 5, 2014 128693976430:194 admin Aug 18, 2013 Sep 5, 2014 173153196431:194 admin Aug 18, 2013 Sep 5, 2014 92364166432:194 admin Aug 18, 2013 Sep 5, 2014 155315006433:194 admin Aug 18, 2013 Sep 5, 2014 103621256434:194 admin Aug 18, 2013 Sep 5, 2014 74981006435:194 admin Aug 18, 2013 Sep 5, 2014 122088956436:194 admin Aug 18, 2013 Sep 5, 2014 170197166437:194 admin Aug 18, 2013 Sep 5, 2014 169850316438:194 admin Aug 18, 2013 Sep 5, 2014 84781446439:194 admin Aug 18, 2013 Sep 5, 2014 190569006441:194 admin Aug 18, 2013 Sep 5, 2014 192088426442:194 admin Aug 18, 2013 Sep 5, 2014 170470876443:194 admin Aug 18, 2013 Sep 5, 2014 92424786444:194 admin Aug 18, 2013 Nov 6, 2013 124671336445:194 admin Aug 18, 2013 Sep 5, 2014 33073076446:194 admin Aug 18, 2013 Sep 5, 2014 126099406447:194 admin Aug 18, 2013 Sep 5, 2014 158834416450:194 admin Aug 18, 2013 Sep 5, 2014 163394766451:194 admin Aug 18, 2013 Sep 5, 2014 186358556452:194 admin Aug 18, 2013 Sep 5, 2014 37888356453:194 admin Aug 18, 2013 Sep 5, 2014 180655926455:194 admin Aug 18, 2013 Sep 5, 2014 169601776456:194 admin Aug 18, 2013 Sep 5, 2014 164816366457:194 admin Aug 18, 2013 Sep 5, 2014 176615656458:194 admin Aug 18, 2013 Nov 6, 2013 182590076459:194 admin Aug 18, 2013 Sep 5, 2014 181803956460:194 admin Aug 18, 2013 Sep 5, 2014 8675093

6461:194 admin Aug 18, 2013 Sep 5, 2014 189889096462:194 admin Aug 18, 2013 Sep 5, 2014 90225616463:194 admin Aug 18, 2013 Sep 5, 2014 36203146464:194 admin Aug 18, 2013 Sep 5, 2014 119043166465:194 admin Aug 18, 2013 Sep 5, 2014 176238016466:194 admin Aug 18, 2013 Sep 5, 2014 77958376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 18410225

Alt ID(s) Title Year Author2008200020031995200520081992199619982005200520082008200720082007200819931999199520082006200720072001200820052004-- Not Found ---- Not Found --1996200620061994200420051991 Ford ES., Cooper RS.2007200820072008199620081996198519891995

















































200320071999200520052003200319971986199919992004200120071994200819941997199620052007200620082009200420072008200620062008200920071995 Lijnen P., Petrov V.200520072006200720071986200820052002198719882006198120032005

Vitamin D, calcium supplementation, and

Grau MV., Baron JA., Sandler RS., Haile RW., Prolonged effect of















































vitamin D intake and McCullough ML., Rodriguez C., Diver WR., Feigelson


25-hydroxyvitamin D levels and the risk of

Melamed ML., Michos ED., Post W., Astor B.Dietary calcium and
















































200819971987200220071995199820082008

Is ischemic stroke risk related to folate status or

Weng LC., Yeh WT., Bai CH., Chen HJ., Chuang SY., Efficacy of









0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Coronary heart

All adenomas

Sudden death

Endocrine system

Gastrointestinal

Colorectal caner

Invasive breast

0 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

slope0 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

IHD (fatal +

Rectal caner

Colorectal adenoma

Change in SBP/DBP

Prostate cancer

Kidney stone

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

CHD0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Distal colon

birth length

Recurrent adenomas

Distal colon

Brain and other

BP (post-partum)

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

areal BMD0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Advance adenomas

Colorectal caner

25(OH)D at 1 y

Bladder cancer

Other cancers

First cardiovas

0 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Fatal IHD Death0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Proximal vs. distal

Weight (ITT)

Hypertension

Brain cancer

Ischemic heart

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Survival Leukemia0 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Prostate cancer in

bone indexes

change in 25 OH(D)

Infectious disease

Digestive system

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Stroke0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

birth weight

Distal colorectal

1,25(OH)D

Lung cancer

Ovarian cancer

All-cause mortality

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

HTN (Rx) SBP mortality0 0 0 0 0 1 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 0

DBP (supine)

Curve 4- Ca

SBP (standing)

Prostate cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 1 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Cancer mortality

BMI (per protocol)

Intestinal polyps

Total cancer

(Invasive) colon

Colon cancer or

Death from

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 1 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

in DBP Women height0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Advanced adenomas

cord blood

Fatal stroke

Chair stands

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

SBP/DBP0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 0

Body weight

Total mortality

Cerebrovascular

Stroke incidence

All cause mortality

change in BMC (ITT

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

% change in total

Femoral neck BMD

All cancers

gestational age

newborn birth

Breast cancer

Total serum

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

CVD Composit

Timed walk

Stomach cancer

(Invasive) colorectal

Total CVD mortality

Ischemic heart

(invasive) rectal

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Cancer related

Nonfatal MI

Breast cancer

BMC - whole

anti-rachitic

Respiratory cancer

Distal (left

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

weight0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Respiratory system

Cardiovascular

Proximal colon

25(OH)D level in

stress fractures

Kidney cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 1 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

BP0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Twelve minutes

weight gain 3rd

Respiratory cancer

Endometrial cancer

Lung cancer

Weight change

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

crown-heel

Colon cancer vs.

atopic eczema at

Coronary heart

25(OH)D level

Incident HTN

Breast cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Myeloma0 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Colorectal cancer

Non-Hodgkin

specific stroke

Total body BMC

Prostate cancer in

Incident breast

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

fracture in SBP stroke0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 1 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Breast cancer

25(OH)vitD

Muscle strength

infant weight

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Weight MI0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 0

9 mo weight

Proximal colon

incident cancer

Rectal cancer

Primary adenocarc

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 1 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

gestational HTN

vit D3 level in

maternal 1,25

Rectal cancer

Pancreatic cancer

cord blood

Cardiovascular

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 1 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Calcium balance

Prostate cancer

Physical performa

Distal colon

high-risk distal

Total stroke

Colon cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

adenoma at 2 mo length BMI0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Pregnancy-induced

Prostate cancer

preeclampsia

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

BMD Others 1 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Aggressive prostate

HTN (BP or Rx)

Systolic BP

Incident invasive

Prostate cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 1 0 0 0 0 0

PI0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

First stroke

incident prostate

No analysis

Rectal adenoma

low-risk (distal)

gestation length

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

toxemia Fall0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 1 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Colorectal cancer

BMD - lumbar

Timed up and go

change in ht

Adenoma recurrenc

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 11 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Proximal and distal

HTN, incident

change in wt

change in BMI

Colorectal cancer

Cerebrovascular

Proximal (right

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

25(OH)D0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 0

25(OH)D level in

prostate cancer

% change in BMC at

Breast cancer

Esophageal cancer

Colon cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 1 0

Respira-ry AMI0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Falls incidence

Thyroid cancer

Digestive cancer

Urinary system

Serum 25(OH)D

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

CVD mortality

9 mo length

Incident stroke

Breast cancer

All cancers

Grip strength

Liver cancer

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

1 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Non-Hodgkin

Serum 25(OH)D

Colon caner

fatal prostate

Reproductive

Bodyweight

Mammography

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 10 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Mortality 25(OH)D20 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Head and neck

body weight

25(OH)D total

Cerebral infarction

specific stroke

0 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

25(OH)D30 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 1 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 1 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 1 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

Prostate cancer

Colorectal Cancer

Adenomas

All cancers

Prostate cancer

Also separate

0 0 0 0 0 0 00 0 0 0 0 0 01 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 1 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 10 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 1 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

0 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 00 0 0 0 0 0 0

DBP CRC IHD death0 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 10 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 0

First fracture

maternal 25(OH)D

Fractures (hip/wrist/

0 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 01 0 0 0 1 00 1 0 0 0 00 0 0 1 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 1 0 0 00 0 0 0 0 0

0 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 0

0 0 0 0 0 00 1 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 00 0 0 0 0 0


Last Updated





6433:194 admin Aug 18, 2013 Sep 5, 2014 103621256434:194 admin Aug 18, 2013 Sep 5, 2014 74981006434:194 admin Aug 18, 2013 Sep 5, 2014 74981006434:194 admin Aug 18, 2013 Sep 5, 2014 74981006435:194 admin Aug 18, 2013 Sep 5, 2014 122088956436:194 admin Aug 18, 2013 Sep 5, 2014 170197166436:194 admin Aug 18, 2013 Sep 5, 2014 170197166436:194 admin Aug 18, 2013 Sep 5, 2014 170197166437:194 admin Aug 18, 2013 Sep 5, 2014 169850316438:194 admin Aug 18, 2013 Sep 5, 2014 84781446438:194 admin Aug 18, 2013 Sep 5, 2014 84781446438:194 admin Aug 18, 2013 Sep 5, 2014 84781446439:194 admin Aug 18, 2013 Sep 5, 2014 190569006439:194 admin Aug 18, 2013 Sep 5, 2014 190569006439:194 admin Aug 18, 2013 Sep 5, 2014 190569006441:194 admin Aug 18, 2013 Sep 5, 2014 192088426442:194 admin Aug 18, 2013 Sep 5, 2014 170470876443:194 admin Aug 18, 2013 Sep 5, 2014 92424786443:194 admin Aug 18, 2013 Sep 5, 2014 92424786443:194 admin Aug 18, 2013 Sep 5, 2014 92424786443:194 admin Aug 18, 2013 Sep 5, 2014 92424786443:194 admin Aug 18, 2013 Sep 5, 2014 92424786444:194 admin Aug 18, 2013 Nov 6, 2013 124671336444:194 admin Aug 18, 2013 Nov 6, 2013 124671336444:194 admin Aug 18, 2013 Nov 6, 2013 124671336444:194 admin Aug 18, 2013 Nov 6, 2013 124671336444:194 admin Aug 18, 2013 Nov 6, 2013 124671336445:194 admin Aug 18, 2013 Sep 5, 2014 33073076446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406446:194 admin Aug 18, 2013 Sep 5, 2014 126099406447:194 admin Aug 18, 2013 Sep 5, 2014 158834416450:194 admin Aug 18, 2013 Sep 5, 2014 163394766450:194 admin Aug 18, 2013 Sep 5, 2014 163394766450:194 admin Aug 18, 2013 Sep 5, 2014 16339476

6450:194 admin Aug 18, 2013 Sep 5, 2014 163394766451:194 admin Aug 18, 2013 Sep 5, 2014 186358556451:194 admin Aug 18, 2013 Sep 5, 2014 186358556451:194 admin Aug 18, 2013 Sep 5, 2014 186358556452:194 admin Aug 18, 2013 Sep 5, 2014 37888356453:194 admin Aug 18, 2013 Sep 5, 2014 180655926455:194 admin Aug 18, 2013 Sep 5, 2014 169601776456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366456:194 admin Aug 18, 2013 Sep 5, 2014 164816366457:194 admin Aug 18, 2013 Sep 5, 2014 176615656457:194 admin Aug 18, 2013 Sep 5, 2014 176615656457:194 admin Aug 18, 2013 Sep 5, 2014 176615656457:194 admin Aug 18, 2013 Sep 5, 2014 176615656457:194 admin Aug 18, 2013 Sep 5, 2014 176615656459:194 admin Aug 18, 2013 Sep 5, 2014 181803956460:194 admin Aug 18, 2013 Sep 5, 2014 86750936460:194 admin Aug 18, 2013 Sep 5, 2014 86750936460:194 admin Aug 18, 2013 Sep 5, 2014 86750936460:194 admin Aug 18, 2013 Sep 5, 2014 86750936461:194 admin Aug 18, 2013 Sep 5, 2014 189889096462:194 admin Aug 18, 2013 Sep 5, 2014 90225616463:194 admin Aug 18, 2013 Sep 5, 2014 36203146464:194 admin Aug 18, 2013 Sep 5, 2014 119043166464:194 admin Aug 18, 2013 Sep 5, 2014 119043166464:194 admin Aug 18, 2013 Sep 5, 2014 119043166465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 18410225

Alt ID(s) Title Year Author2008200820002003200320031995200520081992199619981998200520052005200520082008200820072008200820082008200820072007200819931995200820082008200620062006200620072007200720012008200520042004-- Not Found --


Ahn J., Peters U., Albanes D., Purdue MP., Abnet CC., Serum vitamin D



calcium intake from diet Al-Delaimy WK., Rimm E., Willett WC., Stampfer MJ., A prospective study of








magnesium, calcium, and Ascherio A., Rimm EB., Hernán MA., Giovannucci Intake of potassium,


a randomized clinical trial Baron JA., Beach M., Wallace K., Grau MV., Risk of prostate cancer in


D and 1,25-Bertone-Johnson ER., Chen WY., Holick MF., Hollis BW., Plasma 25-hydroxyvitamin














vitamin D, and dairy food Bostick RM., Potter JD., Sellers TA., McKenzie DR., Prostate cancer and


















-- Not Found ---- Not Found ---- Not Found ---- Not Found --19961996200620062006200620062006200619941994200420042004200420052005200520072008200720072007200720072007200720072008199620082008200820082008199619851989199519952007200719991999

Vitamin D and prostate cancer: a prediagnostic

Corder EH., Guess HA., Hulka BS., Friedman GD., Vitamin D and prostate




and incidence of treated Dwyer JH., Li L., Dwyer KM., Curtin LR., Feinleib M.Dietary calcium, alcohol,









variations in the growth Feliciano ES., Ho ML., Specker BL., Falciglia G., Seasonal and geographical


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Outcome Outcome Definition Commentsnd nd SUBVALUE() nd

ndnd nd SUBVALUE() nd SUBVALUE() nd

2 SUBVALUE() -1 SUBVALUE() -1 SUBVALUE() -

Change in kg/yr 2 SUBVALUE() nd1 SUBVALUE()

nd SUBVALUE() nd1 1 SUBVALUE() -

1 SUBVALUE() -1 SUBVALUE() nd

not extracted - - - -Secondary - -Secondary - -

- - - -nd

All cause - - - -nd SUBVALUE() nd

ndnd

- - - -- - - -- - - -- - - -nd SUBVALUE()nd SUBVALUE()2 SUBVALUE() nd SUBVALUE()

nd

ndndndndndnd

Fall SUBVALUE() ndFall SUBVALUE() nd

ndWeight [Kg] Kg Kg SUBVALUE() nd

nd

nd

- - - -

Outcome Description

Primary / Secondary Prostate cancer

[nd:Categorical]secondary SUBVALUE()

Prostate cancer SUBVALUE()Aggressive

prostate cancer Gleason sum >=7 or clinical stage III

secondary SUBVALUE()

Aggressive prostate cancer

Gleason sum >=7 or clinical stage III Prostate cancer

[nd:Categorical]Prostate cancer SUBVALUE()IHD (fatal +

nonfatal) [Implied Implied combination of

Total ischemic heart disease

Implied combination of Nonfatal MI [Self-

reporting with Self-reporting with medical record

Nonfatal MI SUBVALUE()

Self-reporting with medical record Fatal IHD

[Including sudden Including sudden death. Death

Fatal ischemic heart disease

Including sudden death. Death Body weight

[Change in Body weight SUBVALUE()

Change in kg/yr SUBVALUE()HTN, incident

[Physician Physician diagnosis (self-

HTN, incident SUBVALUE()

Physician diagnosis (self-

In a validation study of 127 25(OH)D

[Continuous]primary SUBVALUE()

25(OH)D SUBVALUE()Incident HTN

[1 :Categorical]Incident HTN SUBVALUE()

self-reported diagnosis Hypertension

[Categorical]Incident HTN SUBVALUE()

Self-reported; apparently did not Incident stroke

[Fatal or nonfatal Fatal or nonfatal stroke by report,

Incident stroke SUBVALUE()

Fatal or nonfatal stroke by report, specific stroke

types [not Prostate cancer risk

Secondary SUBVALUE()

Incident cases were sought Total serum PSA

[Secondary:CategSecondary SUBVALUE()

Prostate-specific antigen Breast cancer risk

[Risk of Risk of developing or newly

Primary SUBVALUE()

Breast cancer risk SUBVALUE()

Risk of developing or newly

Blood were withdrawn in 3 Breast cancer risk

by age <60y and Risk of developing or newly 25(OH)D level

[Changes from Changes from baseline to 6-

Primary SUBVALUE()

25(OH)D level SUBVALUE()

Changes from baseline to 6-Mortality [All

cause:Continuous]25(OH)D at 1 y [Continuous]

Primary SUBVALUE()

25(OH)D at 1 y SUBVALUE()preeclampsia

[gestational HTN gestational HTN & proteinuria and

primary SUBVALUE()

preeclampsia SUBVALUE()

gestational HTN & proteinuria and Death [Family,

hospital, and Family, hospital, and national

1 (this analysis; 2 for original RCT)

Death SUBVALUE()

Family, hospital, and national Sudden death

[Standard criteria Standard criteria adjudicated by MI [Standard

criteria Standard criteria adjudicated by Stroke [Standard

criteria Standard criteria adjudicated by CVD Composite

(MI, Stroke, composite Adjudicated Femoral neck BMD

[DEXA of the DEXA of the femur was carried out

Femoral neck BMD SUBVALUE()

DEXA of the femur was carried out

Original RCT had 4 groups: placebo, 25(OH)D

[Measured at Measured at baseline and

25(OH)D SUBVALUE()

Measured at baseline and

Original RCT had 4 groups: placebo, Weight

[Continuous]weight SUBVALUE()

Study was a RCT crossover design Colon cancer

[State Health State Health registry of

Not explicitly described but the

Colon cancer SUBVALUE()

State Health registry of Prostate cancer

[25(OH)D] Diagnosed 1980-1992, 6-18 y after

Primary (in post hoc analysis,

Prostate cancer SUBVALUE()

Diagnosed 1980-1992, 6-18 y after

Blood samples drawn only from Grip strength [Two

measurements Two measurements


Grip strength SUBVALUE()

Two measurements Chair stands

[Conducted if the Conducted if the subject was able


Chair stands SUBVALUE()

Conducted if the subject was able Timed walk [The

timed walk utilized The timed walk utilized a course


Timed walk SUBVALUE()

The timed walk utilized a course Muscle strength

[Isometric Isometric quadriceps

primary SUBVALUE()

Muscle strength SUBVALUE()

Isometric quadriceps Physical

performance Endurance (The distance that


Physical performance

Endurance (The distance that 25(OH)vitD [No

assay information]No assay information


25(OH)vitD SUBVALUE()

No assay information Fall [Fall free

survival Fall free survival curve


Fall free survival curve SUBVALUE()Fall [Defined as

the patient Defined as the patient

primary SUBVALUE()

Defined as the patient fracture [Any

fracture incurred Any fracture incurred during

primary SUBVALUE()

fracture SUBVALUE()

Any fracture incurred during 2 (1 for this

article) Weight SUBVALUE()Prostate cancer

[Requested Requested permission to



Requested permission to Incident invasive

breast cancer Confirmed by both local and central

Not clear. Most likely secondary

Incident invasive breast cancer

Confirmed by both local and central

The trial is unable to discern the bone indexes [by

dual-energy X-ray by dual-energy X-ray

primary SUBVALUE()

bone indexes SUBVALUE()

by dual-energy X-ray Weight change

[Change in weight Change in weight in kg

Primary SUBVALUE()

Weight change SUBVALUE()

Change in weight in kg SUBVALUE()

NS but substantial differences (in Curve 4- Ca

25(OH)D [Change Change in 25(OH)D after 6 Prostate cancer

diagnosis Invasive adenocarcinoma

Primary SUBVALUE()

Prostate cancer diagnosis

Invasive adenocarcinoma

To avoid exclusion of all 19 controls

Gleason gradeDeath record

nd SUBVALUE()nd SUBVALUE()1 SUBVALUE() nd- - - -nd SUBVALUE() nd

BMI [Continuous] nd SUBVALUE() BMI SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() nd

nd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() nd

nd SUBVALUE() nd- - - -nd SUBVALUE() nd

Colon cancer [nd] nd nd SUBVALUE() nd SUBVALUE() ndRectal cancer [nd] nd nd SUBVALUE() nd SUBVALUE() nd

nd nd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd

Same as above - - - -- - - -

ndndndndndndndndndnd

nd SUBVALUE()- - - -- - - -- - - -- - - -nd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() -

Kg 2 SUBVALUE() Kg SUBVALUE() ndSBP/DBP - - - -

ndnd SUBVALUE() nd

sum of D2 and D3 nd- - - -

Prostate cancer stage [Gleason


Prostate cancer stage SUBVALUE()

Gleason grade SUBVALUE()

To avoid exclusion of all 19 controls Prostate cancer

death [Death Secondary SUBVALUE()

Prostate cancer death SUBVALUE()

Death record SUBVALUE()

To avoid exclusion of all 19 controls Adenomas

recurrence [nd nd (only for patients with

Adenomas recurrence

nd (only for patients with

This publication includes two Survival [nd (only

for patients with nd (only for patients with CRC

Survival SUBVALUE()

nd (only for patients with CRC

This publication includes two HTN (Rx) [HTN

medication HTN medication prescribed

Incident HTN SUBVALUE()

HTN medication prescribed HTN (BP or Rx)

[SBP 160 or DBP SBP 160 or DBP 95 or medication Weight [To the

nearest 0.5 pound To the nearest 0.5 pound (1.1 kg),

Weight SUBVALUE()

To the nearest 0.5 pound (1.1 kg),

% change in BMC at the lumber

Primary SUBVALUE()

% change in BMC at the lumber % change in total

hip BMC Primary SUBVALUE()

% change in total hip BMC 25(OH)D

[Continuous]25(OH)D SUBVALUE()height

[Continuous]Height SUBVALUE()Weight

[Continuous]Weight SUBVALUE()weight


weight SUBVALUE()length

[Continuous]Colorectal cancer [Reported by a

Reported by a participant on a

Colorectal cancer SUBVALUE()

Reported by a participant on a Colon cancer

SUBVALUE()Rectal cancer SUBVALUE()Proximal and

distal colon cancer Proximal and distal colon cancer Colorectal cancer

[Self reports, Self reports, statewide cancer


Self reports, statewide cancer Colon cancer vs.

rectal cancer Proximal vs. distal colon cancer

Same as above (not data Incident HTN

[Subject reporting Subject reporting that their

1 (for this post hoc analysis)

Incident HTN SUBVALUE()

Subject reporting that their Hypertension

[Self-reported by Self-reported by the health

Primary SUBVALUE()

Hypertension SUBVALUE()

Self-reported by the health Cancer mortality

[Based on ICD-10 Based on ICD-10 codes#

Primary SUBVALUE()

Cancer mortality SUBVALUE()

Based on ICD-10 codes# Lung cancer

mortality [Based Based on ICD-10 codes#


Lung cancer mortality

Based on ICD-10 codes# Digestive cancer



Digestive cancer mortality

Based on ICD-10 codes# Breast cancer



Breast cancer mortality

Based on ICD-10 codes# Prostate cancer



Prostate cancer mortality

Based on ICD-10 codes# Non-Hodgkin s

lymphoma/leukemBased on ICD-10 codes#


Non-Hodgkin s lymphoma/leukem

Based on ICD-10 codes# Colorectal cancer



Colorectal cancer mortality

Based on ICD-10 codes# Other cancers



Other cancers mortality

Based on ICD-10 codes# Breast cancer risk

[Incident breast Incident breast cancer classified

Primary outcome SUBVALUE()

Breast cancer risk SUBVALUE()

Incident breast cancer classified

Used quintiles to assess sensitivity Colon cancer

[Norwegian cancer Norwegian cancer registry

Primary (only reported outcome)


Norwegian cancer registry

Rectal cancer not reported in this birth length


birth length SUBVALUE()

Data from a longitudinal cohort birth weight

[Continuous]9 mo length [Continuous]9 mo weight [Continuous]atopic eczema at 9 mo [modified UK

modified UK Working Party Prostate cancer

[Medical records Medical records and pathology


Medical records and pathology Colorectal cancer

[Medical and Medical and hospital records


Medical and hospital records Colon cancer [ICD-

8 153.0-153.8 ICD-8 153.0-153.8 (probably registry


ICD-8 153.0-153.8 (probably registry Weight

[Kg:Continuous]Weight SUBVALUE()

All adenomas [For each colonoscopy

For each colonoscopy a

Primary SUBVALUE()

All adenomas SUBVALUE()

For each colonoscopy a Advance

adenomas Advanced lesions were defined as

Advance adenomas

Advanced lesions were defined as 25(OH)D total

[sum of D2 and secondary SUBVALUE()

25(OH)D total SUBVALUE()

sum of D2 and D3 SUBVALUE()25(OH)D2

[Continuous]

- - - -nd SUBVALUE()nd SUBVALUE()

ndBP (post-partum) 2 SUBVALUE() nd SUBVALUE()

slope SUBVALUE() ndndnd

nd nd SUBVALUE() ndnd

- - - -- - - -

birth weight nd SUBVALUE() ndbirth length - - - -gestational age - - - -

nd SUBVALUE() ndBMI [Continuous] - - - -

nd SUBVALUE() ndnd

nd SUBVALUE() ndnd SUBVALUE()nd SUBVALUE()nd SUBVALUE() nd

ndnd SUBVALUE() nd

nd SUBVALUE()- - - -- - - -

ndnd

nd SUBVALUE() nd- - - -- - - -- - - -- - - -

ndndndndnd

1 SUBVALUE() nd- - - -- - - -- - - -

ndnd

2 SUBVALUE() nd- - - -

25(OH)D3 [Continuous]Recurrent adenomas

Ascertained by complete

Recurrent adenomas

Ascertained by complete

This original study (The Polyp Advanced

adenomas Subjects had maximal diameter

Advanced adenomas

Subjects had maximal diameter

This original study (The Polyp Body weight

[Change in Change in bodyweight in kg

Primary SUBVALUE()

Body weight SUBVALUE()

Change in bodyweight in kg BP (post-partum)

SUBVALUE()RCT was conducted during slope [ 25(OH)D/

vitD dose]25(OH)D/ vitD dose

primary SUBVALUE()

25(OH)D/ vitD dose SUBVALUE()Body weight

[Change in kg Change in kg over 30 months



Change in kg over 30 months Colon cancer

[Confirmed Confirmed through hospital

Only reported outcome but two


Confirmed through hospital Prostate cancer

[nd:Categorical]secondary SUBVALUE()

Prostate cancer SUBVALUE()Colorectal cancer

[Finish cancer Finish cancer registry (ICD153-

Not explicitly described


Finish cancer registry (ICD153-Colon cancer

[Finish cancer Finish cancer registry (no clear Rectal cancer

[Finish cancer Finish cancer registry (no clear primary

SUBVALUE()birth weight SUBVALUE()

weight [Analyzed by a bipedal-

Analyzed by a bipedal-bimanual

weight SUBVALUE()

Analyzed by a bipedal-bimanual

Colorectal cancer [Record linkage to

Record linkage to cancer registries


Record linkage to cancer registries Colorectal Cancer

[Self reports (in Self reports (in the questionnaires

Not explicitly stated but the

Colorectal Cancer SUBVALUE()

Self reports (in the questionnaires Colon caner

[Response to the Response to the biennial

Colon caner SUBVALUE()

Response to the biennial adenoma

[Complete Complete colonoscopy was

adenoma SUBVALUE()

Complete colonoscopy was

High risk of adenomas was Colorectal cancer

[Mostly diagnosed Mostly diagnosed when


Mostly diagnosed when

High risk of adenomas was Incident breast

cancer [Self Self reported and identified through

Incident breast cancer

Self reported and identified through prostate cancer

[self-reported of self-reported of physician-

primary SUBVALUE()

prostate cancer SUBVALUE()

self-reported of physician-Prostate cancer

[Active patient Active patient notification from


Active patient notification from change in BMI

[Continuous]secondary SUBVALUE()

change in BMI SUBVALUE()

study funded the calcium enriched change in wt

[Continuous]change in ht [Continuous]incident cancer [from medical

from medical record (including


incident cancer SUBVALUE()

from medical record (including stress fractures

[Stress fractures Stress fractures were ascertained

primary SUBVALUE()

stress fractures SUBVALUE()

Stress fractures were ascertained Colorectal caner

[National Swedish National Swedish Cancer Register (-

Colorectal caner SUBVALUE()

National Swedish Cancer Register (-Colon caner

[National Swedish National Swedish Cancer Register (-Rectal caner

[National Swedish National Swedish Cancer Register (-Proximal colon

caner [National National Swedish Cancer Register (-Distal colon caner

[National Swedish National Swedish Cancer Register (-Colorectal caner



Colorectal caner SUBVALUE()

National Swedish Cancer Register (-Colon caner



Colon caner SUBVALUE()

National Swedish Cancer Register (-Rectal caner



Rectal caner SUBVALUE()

National Swedish Cancer Register (-Proximal colon

caner [National National Swedish Cancer Register (-


Proximal colon caner SUBVALUE()

National Swedish Cancer Register (-Distal colon caner



Distal colon caner SUBVALUE()

National Swedish Cancer Register (-First stroke (and

subtypes) Hospital discharge and death

First stroke (and subtypes)

Hospital discharge and death Cerebral infarction

included here Also separate analysis for much No analysis of total stroke.Invasive breast cancer [Linkage

Linkage with national and

Primary SUBVALUE()

Invasive breast cancer

Linkage with national and Prostate cancer

[Tumor Gleason Tumor Gleason score, grade,



Tumor Gleason score, grade, SBP/DBP

[Standing and Standing and supine

SBP/DBP SUBVALUE()

Standing and supine 25(OH)D

[Competitive Competitive protein binding

- - - -nd SUBVALUE() nd- - - -- - - -

nd SUBVALUE()- - - -- - - -

ndnd

nd nd SUBVALUE() ndKg 2 SUBVALUE() Kg SUBVALUE() nd

BMI [Continuous] - - - -SBP [Continuous] - - - -DBP [Continuous] - - - -

nd SUBVALUE()- - - -- - - -- - - -- - - -

nd1 SUBVALUE() AMI SUBVALUE() nd

Same - - - -nd

nd nd SUBVALUE() ndnd SUBVALUE() nd

- - - -nd SUBVALUE() ndnd SUBVALUE() nd

- - - -

- - - -- - - -- - - -

nd- - - -- - - -- - - -nd SUBVALUE() nd

ndnd SUBVALUE() nd

gestation length - - - -- - - -

ndDXA BMD SUBVALUE() DXA SUBVALUE() nd

2 SUBVALUE() SBP SUBVALUE() ndSame as SBP - - - -

- - - -

1,25(OH)D [Radioreceptor

Radioreceptor assay (Medgenix Colorectal cancer

[Follow-up Follow-up questionnaire


Follow-up questionnaire Proximal colon

cancer [Not fully Not fully defined (data not Distal colon

cancer [Not fully Not fully defined (data not Breast cancer

[Incident cases of Incident cases of invasive breast

Primary SUBVALUE()

Breast cancer SUBVALUE()

Incident cases of invasive breast

Vit D sources estimated from body weight


body weight SUBVALUE()

enrolled subject stratified by two height

[Continuous]25(OH)D [Continuous]First fracture [Confirmed by

Confirmed by matching every

Primary SUBVALUE()

First fracture SUBVALUE()

Confirmed by matching every Fractures

(hip/wrist/forearm/Confirmed by matching every


Fractures (hip/wrist/forearm/

Confirmed by matching every Mortality

[nd:Categorical]Secondary SUBVALUE()

Mortality SUBVALUE()Weight

[Kg:Continuous]Weight SUBVALUE()

maternal 25(OH)D at term

primary SUBVALUE()

maternal 25(OH)D at term

unsupplemented group was not cord blood

25(OH)D at termmaternal 1,25 (OH)2D at termcord blood 1,25 (OH02D at term birth weight [Continuous]Hypertension [Self-report of

Self-report of medication

primary SUBVALUE()

Hypertension SUBVALUE()

Self-report of medication AMI [ICD 9 codes

from national ICD 9 codes from national death

ICD 9 codes from national death Stroke

[Same:CategoricalAdenoma recurrence [One

One or more adenomas or

primary SUBVALUE()

Adenoma recurrence

One or more adenomas or toxemia

[nd:Categorical]primary SUBVALUE()

toxemia SUBVALUE()newborn birth

weight primary SUBVALUE()

newborn birth weight crown-heel length

[Categorical]25(OH)D [Continuous]

primary SUBVALUE()

25(OH)D SUBVALUE()weight gain 3rd

trimesterprimary SUBVALUE()

weight gain 3rd trimester birth weight

[Continuous]Colorectal cancer [Confirmed

Confirmed incident cases of

primary SUBVALUE()


Confirmed incident cases of

Data on total energy intake are Proximal colon

cancer [Cancer at Cancer at cecum to splenic flexureDistal colon

cancer [Cancer at Cancer at descending to Rectal cancer

[Cancer at rectum Cancer at rectum and rectosigmoid All-cause mortality

[Linked National Linked National Death Index

primary SUBVALUE()

All-cause mortality SUBVALUE()

Linked National Death Index CVD mortality

[Cause-specific Cause-specific death was coded Cancer mortality

[Including all Including all malignant Infectious disease

mortality Including deaths from infectious Mammography

density [Ratio of Ratio of the absolute area of

Mammography density

Ratio of the absolute area of prostate cancer

[Finnish Cancer Finnish Cancer Registry (medical

primary SUBVALUE()


Finnish Cancer Registry (medical birth weight


birth weight SUBVALUE()

crown-heel length [Continuous]preeclampsia [HTN (DBP 90

HTN (DBP 90 mm) and

primary SUBVALUE()


HTN (DBP 90 mm) and BMD

[DXA:Continuous]primary SUBVALUE()SBP [Automated

OMRON electronic Automated OMRON electronic

Automated OMRON electronic DBP [Same as

SBP:Continuous]25(OH)D [Continuous]

nd SUBVALUE()nd

nd SUBVALUE() ndnd

gestational HTN - - - -nd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() nd

ndnd SUBVALUE() ndNd*** SUBVALUE() nd- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

The same as NHL - - - -The same as NHL - - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -1 SUBVALUE() SBP SUBVALUE()

Same as SBP - - - -- - - -

nd SUBVALUE() ndKg, BMI 2 SUBVALUE() nd

BP [SBP, DBP] SBP, DBP - - - -nd SUBVALUE() nd

nd1 SUBVALUE() nd SUBVALUE() nd

Serum 25(OH)D change

Primary SUBVALUE()

Serum 25(OH)D change

The actual mean D3 content of the prostate cancer

[biopsy or surgical biopsy or surgical specimen;

primary SUBVALUE()


biopsy or surgical specimen; Colorectal

adenoma Reviewed the medical records

Colorectal adenoma

Reviewed the medical records preeclampsia [BP

>140/90 & BP >140/90 & proteinuria

primary SUBVALUE()


BP >140/90 & proteinuria

Colorectal cancer [Adenocarcinoma

Adenocarcinoma (Collected for the


Adenocarcinoma (Collected for the Colon cancer [See

above (ICD180-See above (ICD180-189 only)


See above (ICD180-189 only) Rectal cancer [See

above (ICD199 See above (ICD199 and 209

Rectal cancer SUBVALUE()

See above (ICD199 and 209 Colorectal cancer

[Identified by Identified by means of linkage


Identified by means of linkage incident prostate

cancer [8 state 8 state cancer registry

primary SUBVALUE()

incident prostate cancer

8 state cancer registry Prostate cancer

[Identified by Identified by linkage of cohort


Identified by linkage of cohort All cancers

[Identified Identified thorough a cancer

All cancers SUBVALUE()

Identified thorough a cancer Head and neck

cancer [The same The same as all cancerEsophageal

cancer [The same The same as all cancerStomach cancer

[The same as all The same as all cancerColorectal cancer

[The same as all The same as all cancerLiver cancer [The

same as all The same as all cancerPancreatic cancer

[The same as all The same as all cancerLung cancer [The

same as all The same as all cancerBreast cancer

[The same as all The same as all cancerOvarian cancer

[The same as all The same as all cancerEndometrial

cancer [The same The same as all cancerBladder cancer

[The same as all The same as all cancerKidney cancer

[The same as all The same as all cancerThyroid cancer

[The same as all The same as all cancerBrain cancer [The

same as all The same as all cancerNon-Hodgkin

lymphoma (NHL) Identified through Surveillance Leukemia [The

same as NHL]Myeloma [The same as NHL]Digestive system [A combined

A combined category. See the Respiratory

system A combined category. See the Reproductive

system [A A combined category. See the Women [A

combined A combined category. See the Urinary system

[A combined A combined category. See the Brain and other

nervous system A combined category. See the Endocrine system

[A combined A combined category. See the Others [A

combined A combined category SBP [Measured

after at least 5 Measured after at least 5 min of

Measured after at least 5 min of

32 (47%) of the subjects in the Ca DBP [Same as

SBP:Continuous]25(OH)D [Continuous]Colon cancer or rectal cancer

Incident cases of colon or rectal

Secondary outcome

Colon cancer or rectal cancer

Incident cases of colon or rectal

In cases of multiple colorectal Distal colorectal

adenoma Adenomatous polyps by review

(distal) colorectal polyps

Adenomatous polyps by review Weight [Kg,

BMI:Continuous]Weight SUBVALUE()

Kg, BMI SUBVALUE()

Prostate cancer [Incident cases

Incident cases identified through


Incident cases identified through incident prostate

cancer [Cancer Cancer Registry; death certificates;

primary SUBVALUE()

incident prostate cancer

Cancer Registry; death certificates; Fatal stroke

[Categorical]Fatal stroke SUBVALUE()Total mortality

[Mortality and Mortality and cause of death

Secondary (assumed because

Total mortality SUBVALUE()

Mortality and cause of death

This paper described first 865

nd SUBVALUE() nd1 SUBVALUE() SBP SUBVALUE()1 SUBVALUE() DBP SUBVALUE()2 SUBVALUE()nd SUBVALUE() nd

Colon cancer - - - -Rectal cancer - - - -

nd SUBVALUE()nd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() nd1 SUBVALUE() nd SUBVALUE() nd

BMI [Continuous] - - - -- - - -nd SUBVALUE()

nd SUBVALUE() nd- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -

Change in kg/yr nd SUBVALUE() ndnd

same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -

- - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -same as above - - - -

nd SUBVALUE() nd1 SUBVALUE() nd

not extracted - - - -- - - -

Prostate cancer [Computerized

Computerized record linkage


Computerized record linkage SBP [BP was

measured twice BP was measured twice pre and post

BP was measured twice pre and post

Complete trial performed during DBP [BP was

measured twice BP was measured twice pre and post

BP was measured twice pre and post

Complete trial performed during 25(OH)D [As

measured by As measured by competitive

25(OH)D SUBVALUE()

As measured by competitive

Complete trial performed during Breast cancer

[Medical records Medical records were obtained for

Breast cancer SUBVALUE()

Medical records were obtained for Colorectal cancer

[Cohort members Cohort members have been

primary SUBVALUE()


Cohort members have been

Subjects were followed until

Pancreatic cancer [Self-reported

Self-reported diagnosis in the 2-

Pancreatic cancer SUBVALUE()

Self-reported diagnosis in the 2-

This article gave a pooled analysis of Gastrointestinal

cancer mortality The residence at death and the

Gastrointestinal cancer mortality

The residence at death and the Cancer mortality

[The residence at The residence at death and the

Cancer mortality SUBVALUE()

The residence at death and the All-cause mortality


All-cause mortality SUBVALUE()

The residence at death and the weight

[Continuous]weight SUBVALUE()

Serum 25(OH)D [Continuous]Pancreatic cancer [Vital status of

Vital status of cohort



2.5% had family history of Pancreatic cancer

[odds ratios (OR) odds ratios (OR) for pancreatic

Cancer SUBVALUE()


odds ratios (OR) for pancreatic

Data also available Colorectal cancer

[Diagnosis of Diagnosis of primary


Diagnosis of primary Colon cancer

[Diagnosis of Diagnosis of primary Colon cancer

(excluding the 2 y Rectal cancer [Diagnosis of

Diagnosis of primary Rectal cancer

(excluding the 2 y Colorectal cancer [Matching two

Matching two independent

primary SUBVALUE()


Matching two independent

Average duration of follow up: 11.3 Colon cancer

[Cancer occurring Cancer occurring above the Rectal cancer

[Cancer occurring Cancer occurring below the Proximal colon

cancer [Cancer Cancer occurring from the cecum Distal colon

cancer [Cancer Cancer occurring from the Bodyweight

[Change in Bodyweight SUBVALUE()

Change in kg/yr SUBVALUE()All cause mortality

[Death certificate Death certificate (based on ICD-9*)


All cause mortality SUBVALUE()

Death certificate (based on ICD-9*) Cardiovascular

disease mortality Ischemic heart disease mortality Cerebrovascular disease mortality All cancers mortality [same as Colorectal caner mortality [same as Respiratory cancer mortality Breast cancer mortality (female) Cardiovascular disease incidence

Death certificate (ICD-9*) and self-Ischemic heart

disease incidence Cerebrovascular disease incidence All cancers incidence [same Colorectal cancer incidence [same Respiratory cancer incidence Breast cancer incidence (female) Falls incidence [same as Prostate cancer [Confirmation

Confirmation through


Confirmation through Total stroke

mortality [Death Death certificates (ICD-9 & 10)

Total stroke mortality

Death certificates (ICD-9 & 10) specific stroke

data [not Coronary heart disease mortality

Death certificates (ICD-9 & 10)

- - - -1 SUBVALUE() nd1 SUBVALUE() nd2 SUBVALUE() nd

Body weight in kg ndnd SUBVALUE() nd

ndnd

nd SUBVALUE() ndnd SUBVALUE() nd

nd nd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() ndnd SUBVALUE() nd

nd SUBVALUE()nd SUBVALUE() nd SUBVALUE()nd SUBVALUE() nd SUBVALUE()nd SUBVALUE()nd SUBVALUE() nd SUBVALUE()

ndPI SUBVALUE() nd

- - - -- - - -

ndnd SUBVALUE() nd1 SUBVALUE() nd SUBVALUE() ndnd SUBVALUE()

- - - -- - - -nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() ndnd SUBVALUE() nd SUBVALUE() nd

in DBP 1 SUBVALUE() nd SUBVALUE()- - - -

BMI [Continuous] - - - -

ndBMD SUBVALUE() ndBMD SUBVALUE() nd

- - - -

Total CVD mortality [Death

Death certificates (ICD-9 & 10), Stroke incidence

(also stroke Participant reporting and

Stroke incidence (also stroke

Participant reporting and Fatal stroke

[Death certificates Death certificates & medical records

Fatal stroke SUBVALUE()

Death certificates & medical records Coronary heart

disease [MI, MI, sudden cardiac death, per

Coronary heart disease

MI, sudden cardiac death, per Body weight [Body

weight in Secondary SUBVALUE()


Body weight in kg SUBVALUE()Colorectal cancer

[Derived from the Derived from the presence of a


Derived from the presence of a mortality [by

death by death certificate

primary SUBVALUE()

mortality SUBVALUE()

by death certificate (Invasive)

colorectal cancer Verified in a blinded fashion

Secondary (primary: hip

(Invasive) colorectal cancer

Verified in a blinded fashion (Invasive) colon

cancer [Excluded Excluded in situ and primary

(Invasive) colon cancer

Excluded in situ and primary (invasive) rectal

cancer [Excluded Excluded in situ and primary

(invasive) rectal cancer

Excluded in situ and primary All cause mortality

[nd:Categorical]All cause mortality SUBVALUE()Death from

colorectal cancer Death from colorectal cancer

Death from colorectal cancer

Death from colorectal cancer Intestinal polyps

[Intestinal polyps Intestinal polyps based on

Intestinal polyps SUBVALUE()

Intestinal polyps based on Kidney stone

[Kidney stone Kidney stone based on

Kidney stone SUBVALUE()

Kidney stone based on Total cancer

incidence Intestinal polyps based on

Total cancer incidence

Intestinal polyps based on Cancer related

mortality [Kidney Kidney stone based on

Cancer related mortality

Kidney stone based on 25(OH)D level in

momprimary SUBVALUE()

25(OH)D level in mom SUBVALUE()

subjects compensated with vit D3 level in

mom [Continuous]vit D3 level in mom SUBVALUE()

subjects compensated with 25(OH)D level in

infant25(OH)D level in infant SUBVALUE()

subjects compensated with anti-rachitic

activity in milk [vit vit D3 and 25 (OH)D in milk

anti-rachitic activity in milk

vit D3 and 25 (OH)D in milk

subjects compensated with infant weight and

lengthinfant weight and length

subjects compensated with First

cardiovascular MI, coronary insufficiency,

Primary SUBVALUE()

First cardiovascular

MI, coronary insufficiency, PI [Change in PI%

of all examined Change in PI% of all examined

Unlcear SUBVALUE()

Change in PI% of all examined PI [Change in

curve of PI% Change in curve of PI% (function of PI [Change in PI%

of each of 5 Change in PI% of each of 5 Calcium balance

[Total fecal Total fecal calcium and urinary

Unlcear SUBVALUE()

Calcium balance SUBVALUE()

Total fecal calcium and urinary stroke [Self-

reported and Self-reported and cross-checked by

stroke SUBVALUE()

Self-reported and cross-checked by Change in

SBP/DBPChange in SBP/DBP Colorectal cancer

[Pathological Pathological diagnosis of


Pathological diagnosis of

No main result for calcium and CRC. Primary

adenocarcinoma Reported as diagnosis of colon

primary SUBVALUE()

Primary adenocarcinoma

Reported as diagnosis of colon

86 cases with colorectal cancer Proximal (right

sided) colon Colon cancer located in cecum, Distal (left sided)

colon cancer Colon cancer located in Colorectal cancer

[The vast majority The vast majority of colorectal


The vast majority of colorectal Colon cancer

[Categorical]Colon cancer SUBVALUE()Proximal colon

cancer Proximal colon cancer Distal colon

cancer Distal colon cancer Rectal cancer

[Categorical]Rectal cancer SUBVALUE()in DBP SUBVALUE()

Eligibility blood pressures in SBP

[Continuous]

Rectal cancer [State Health

State Health Registry of Iowa,


Rectal cancer SUBVALUE()

State Health Registry of Iowa,

Primary outcome: mortality; cancer 25(OH)D

[Measured by Measured by competitive


25(OH)D SUBVALUE()

Measured by competitive BMD [Measured at

the hip with an Measured at the hip with an

Primary SUBVALUE()

Measured at the hip with an BMD [Hip and

total body. Hip and total body. DXA

primary SUBVALUE()

Hip and total body. DXA 25(OH)D

[Continuous]

nd nd nd Yes BMInd nd nd Yes BMI

nd nd Yes Yes BMIYes Energy intake Yes Age Yes BMIYes Energy intake Yes Age Yes BMIYes Energy intake Yes Age Yes BMInd nd No nd No ndYes Yes Age, Sex Yes BMInd nd Yes* age Yes/no* nd- - Yes Age Yes BMInd nd Yes Age Yes BMIYes Yes Age Yes BMIYes Yes Age Yes BMILog-calories - Yes - no -Log-calories - Yes - no -

nd nd Yes BMI at age 18 ndnd nd Yes BMI at age 18 nd

nd nd no* nd no* ndnd nd no* nd no* ndnd nd Yes* age, sex Yes* BMInd nd Yes* race, education Yes* prepregnancy BMINo nd Yes But all 55 yo No ndNo nd Yes But all 55 yo No ndNo nd Yes But all 55 yo No ndNo nd Yes But all 55 yo No ndNo nd Yes But all 55 yo No nd

nd Yes* nd Yes* ndnd Yes* nd Yes* nd

No nd no* nd no* ndnd Yes (age, parity) nd Yes (height) nd

None nd Yes No ndYes Yes* Yes* Weight <127 lb**Yes Yes* Yes* Weight <127 lb**Yes Yes* Yes* Weight <127 lb**nd nd no* nd no* ndnd nd no* nd no* ndnd nd no* nd no* ndnd nd no* nd no* ndnd no* nd no* ndnd no* nd no* ndYes Yes Yesnd nd Yes* - Age nd Yes* - BMI nd

nd Yes nd Yes ndnd nd Yes* age Yes* BMI; Tanner stagend nd Yes age Yesnd nd Yes age YesNo nd Yes No nd

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups Total calcium

intakeTotal calcium intake Age (matched),

residence

Na consumption, total energy

Total energy intakeTotal energy intake

Yes; plasma alpha-carotene

Yes (matched by age, menopausal Yes; plasma

alpha-carotene Yes (matched by age, menopausal

total energy intake, calcium total energy intake, calcium

Yes (total energy intake, total Vit E Age (matched &

subgroup Total Ca intake <600mg**

Age (continuous), age 70 years or Total Ca intake

<600mg**Age (continuous), age 70 years or Total Ca intake

<600mg**Age (continuous), age 70 years or

No statistical analysis of No statistical analysis of Total Ca intake Total

Age, race, education

BMI, waist circumference

Both arms liberally used Ca D

Baseline body weightBaseline body weightRace (matched),

age (matched)

No nd Yes No ndNo nd Yes No ndNo nd No nd No ndNo nd No nd No ndYes Calories Yes Age, Sex, Race Yes BMIYes Calories Yes Age, Sex, Race Yes BMI

nd No nd Yes* - BMI ndnd No nd Yes* - BMI nd

nd no* nd no* ndnd no* nd no* ndnd no* nd no* ndnd no* nd no* ndnd no* nd no* ndnd nd no* nd no* ndnd nd no* nd no* nd

nd Yes - BMI ndnd Yes - BMI ndnd Yes - BMI ndnd Yes - BMI nd

nd nd ndnd nd ndnd nd nd

nd nd Yes YesYes Yes* Age**, race** Yes* BMI

nd ndnd ndnd ndnd ndnd ndnd ndnd ndnd nd

nd nd nd Yes - BMI ndEnergy nd Yes (BMI, height) ndnd nd Yes* age no* ndnd nd Yes* age no* ndnd nd Yes* age no* ndnd nd Yes* age no* ndnd nd Yes* age no* ndnd nd Yes Age (match) No nd

nd Yes* - age nd Yes* - BMI nd- Yes - No -nd nd No nd ndnd nd No nd ndnd Yes* - Age, gender nd no* ndnd Yes* - Age, gender nd no* ndnd nd Yes* age Yes* BMInd nd Yes* age Yes* BMI

Race (matched), age (matched)Race (matched), age (matched)

Yes energy intakeYes energy intake Dietary calcium

intake was Dietary calcium intake was Dietary calcium intake was Dietary calcium intake was Dietary calcium intake was

Intakes of calcium, folate, methionine,

Matching factors: year of birth,

Yes matched on ageIntakes of calcium,

folate, methionine, Matching factors: year of birth,





Yes matched on agefolate, vitamin D,

fiber, meat, fat, Age, education (through high

body mass index (kg/m2), heightfolate, vitamin D,


body mass index (kg/m2), heightfolate, vitamin D,


body mass index (kg/m2), heightAge and race were

included in all BMI was included in all modelsCa, phosphorus,

uric acidYes (calcium intake and serum

Final model includes: sex,

Yes (sex, race/ethnicity, and

Yes (BMI and total body fat)Yes (calcium

intake and serum Final model includes: sex,




















Yes (BMI and total body fat)Yes, age at first

birth, raceYes (age [20-44/45-49/55-],

Men and women were separately

Yes (Dietary intake) Matching factors:

race, sex, age, No (NA for weight analysis)No (NA for weight analysis)For analysis of

subjects who did For analysis of subjects who did

nd nd Yes* age Yes* BMIEnergy intake nd nd Yes/no* ndEnergy intake nd nd Yes/no* ndnd nd No nd No ndnd nd No nd No ndnd nd Yes* age, sex Yes*nd nd No nd No ndNo nd Yes (age) nd no* ndnd nd Yes age Yes BMI

Yes (Age, sex) nd Yes (BMI) ndYes (Age, sex) nd Yes (BMI) ndYes (Age, sex) nd Yes (BMI) nd

nd nd no* nd no* ndnd nd no* nd no* ndnd nd no* nd no* ndYes Yes YesYes Yes Yes

nd nd No ndnd nd No ndnd Yes (age) nd Yes (BMI) ndnd Yes - education nd Yes - BMI ndnd Yes - education nd Yes - BMI ndnd nd Yes (BMI) nd

Yes Yes age Yes BMInd Yes age No nd

Yes No nd Yes wt; htYes No nd Yes wt; htYes No nd Yes wt; htnd nd no* nd no* ndnd nd Yes No nd

nd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) nd

Yes Yes Age Yes BMIYes Yes Age Yes BMIYes Yes Age Yes BMIYes Yes Age Yes BMI

nd Yes Age, education Yes BMI, heightnd nd Yes No ndnd nd No nd No ndnd nd No nd No nd

Yes/no* - age, genderYes/no* - age, gender

body weight, % body fat

Yes (Dietary energy intake)

Folic acid, fiber taken into account Yes (Dietary

energy intake)Folic acid, fiber taken into account Yes (Dietary

energy intake)Folic acid, fiber taken into account

All three groups on 7 MJ/day diet

All three groups matched on age

Groups matched on BMI and % All three groups

on 7 MJ/day dietAll three groups matched on age

Groups matched on BMI and % Yes (any vitamin

suppl. use, Yes (age, gender, level of education)Yes (total energy

intake)Yes (age, education)Yes (red meat,

saturated fat, Energy and alcohol intakeEnergy and alcohol intakeSupplement use, saturated fatty

Yes (education level, marital red meat intake,

vegetable intakeIntake of green tea and genistein baseline wt,

energy and baseline wt, energy and baseline wt, energy and

Age group (<25 vs. >=25 yr)Yes (multivitamin,

total energy, Yes (age, education)Yes (multivitamin,









total energy, Yes (age, education)Total energy

intakeTotal energy intakeTotal energy intakeTotal energy intakeTotal energy

intake, fiber Age (matched), race

nd nd No nd No ndnd Yes (age) nd Yes (BMI) ndnd Yes (age) nd Yes (BMI) ndnd Yes (age) nd Yes (BMI) nd

Yes Yes Yes BMIYes calcium intake Yes age YesYes calcium intake Yes age YesYes calcium intake Yes age Yesnd nd Yes -age, gender nd No ndnd nd Yes -age, gender nd No ndnd nd Yes -age, gender nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndnd nd Yes* age, race no* ndnd nd Yes* age, race no* ndnd nd Yes* age, race no* ndnd nd Yes* age, race no* ndnd nd Yes* age, race no* ndnd Yes* Yes* BMIYes (Ca analyses) Yes Age, sex No ndYes (Ca analyses) Yes Age, sex No nd

nd Yes (age; gender) nd No ndnd nd No nd No ndnd nd No nd Yesnd nd No nd Yesnd nd Yes age No ndnd nd No nd No ndnd nd No nd No nd

nd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd Yes Yes BMInd Yes Yes BMInd Yes Yes BMInd Yes Yes BMI

Yes Yes Yes at the age of 53 yYes Yes age, education Yes BMI; Htnd nd Yes infant sex Yes maternal heightnd nd Yes infant sex Yes maternal heightnd nd Yes infant sex Yes maternal heightnd nd Yes race Yes BMInd nd No nd No ndnd nd nd ndnd nd nd ndnd nd nd nd

Yes (multivitamin, saturated fat, red Yes (multivitamin, saturated fat, red Yes (multivitamin, saturated fat, red multivitamin use

and total energy age at menopause and weight, height,

body fatweight, height, body fatweight, height, body fat

Ca intake, VitD intake, sodium

Age, race, education,Weight adjusted

intake of total Weight adjusted intake of total Dietary fiber; total

vitamin D; energy

weight gain in 3rd trimesterweight gain in 3rd trimester

Yes (total energy, %saturated fat

Yes (age; gender; education)Yes (total energy,

%saturated fat Yes (age; gender; education)Yes (total energy,

%saturated fat Yes (age; gender; education)Yes (total energy,

%saturated fat Yes (age; gender; education)Use of vitamin D

supplementationAge, sex, race, low SES statusUse of vitamin D



supplementationAge, sex, race, low SES statusTotal energy

intakeage at the time of mammogram; age total energy

intake

Yes groups matched on age,

Yes groups matched on BMI, Yes groups

matched on age, Yes groups matched on BMI, Yes groups

matched on age, Yes groups matched on BMI,

Yes Yes* Age Yes*No nd nd No nd

nd Yes - age nd Yes - BMI ndnd nd Yes Yes prepregnancy BMInd nd Yes Yes prepregnancy BMI

Yes - age, gender nd Yes - BMI ndYes - age, gender nd Yes - BMI ndYes - age, gender nd Yes - BMI nd

nd nd Yes - BMI, ndYes Yes Yes BMIEnergy intake nd Yes Yes BMI

nd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd nd

nd nd No nd No ndnd nd No nd No ndnd nd No nd No nd

nd nd Yes [BMI (tertiles)] ndnd Yes - BMI nd

nd nd No nd No ndnd nd No nd No nd

nd Yes No ndnd Yes age Yes BMI at age 21nd nd Yes Age matched Yes BMINo nd Yes age; gender nd No nd

VitD intake, Ca intake

BMI, total body fat %, height, weightYes (age, month &

year of exam, Energy intake, energy-adjusted age; race;

educationage; race; educationEnergy intake,

vitamin Matching factors: sex, age, date of Energy intake,

vitamin Matching factors: sex, age, date of Energy intake,

vitamin Matching factors: sex, age, date of Total energy

intake, dietary Yes - ethnicity, agetomato, red meat,

fish , vit E, -age; race; educationEthnicity, educationYes (intake of

fruits and Yes (race/ethnicity,

Yes (body mass indexYes (intake of


















































Yes (body mass index

Yes (supplement group; calcium

Yes [age (for 5-year categories); Yes: Intake of red

meat and Matching factors: endoscopy during

Yes matched on age

Total energy intake, total fat

Age at entry, education, raceenergy intake;

tomato; saturated

Yes Yes Age-adjusted No ndnd nd No Nond nd No Nond nd No No

nd ndnd nd No ndnd nd No ndnd nd No nd

Yes age Yes BMI, heightnd Yes - age nd No ndnd Yes - age nd No ndnd Yes - age nd No ndnd nd ndnd nd ndnd nd nd

nd nd Yes* nd Yes* BMIYes serum retinol Yes No nd

nd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd Yes (BMI) ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd nd

nd nd No nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No ndNo nd nd No nd

nd Yes No ndYes Yes Age Yes BMIYes Yes Age Yes BMIYes Yes Age Yes BMI

Intake of Ca adjusted for NS diff. in age

between groupsNS diff. In BMI and body weight NS diff. in age

between groupsNS diff. In BMI and body weight NS diff. in age

between groupsNS diff. In BMI and body weight Total energy

intake, total fat For the analysis of postmenopausal

Yes - age, BMI at age 18

Yes - height, weight change Yes (vitamin

supplement use Yes (age at recruitment, Yes (vitamin

supplement use Yes (age at recruitment, Yes (vitamin

supplement use Yes (age at recruitment, Use of

multivitamin Two statistical models: with and Energy intake,

dietary fiberEnergy intake, dietary fiberEnergy intake, dietary fiberYes 3 groups matched on vit D

Yes 3 groups matched on age,

Yes 3 groups matched on BMI, Yes 3 groups

matched on vit D Yes 3 groups matched on age,

Yes 3 groups matched on BMI, Yes 3 groups

matched on vit D Yes 3 groups matched on age,

Yes 3 groups matched on BMI,

education, occupational Yes (fat, fiber,

protein, calcium, Yes (matched on age, education)Yes (fat, fiber,




protein, calcium, Yes (matched on age, education)Yes (red meat,

energy adjusted Yes (age: in 5 year age groups;

Yes (BMI in quartiles)Yes (red meat,








Yes (BMI in quartiles)

Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Yes (Age, gender [subgroup])Energy intake,

recreational and Age, race, educationK intake, total

energy intakeK intake, total energy intakeK intake, total energy intake

Yes Yes Age Yes BMIYes Yes Age, sex Yes BMIYes Yes Age, sex Yes BMIYes Yes Age, sex Yes BMInd nd No nd No nd

nd Yes* - age, gender nd Yes/no* ndnd nd nd Yes/no* ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd Yes (age) nd Yes ndnd nd Yes* age, race Yes*nd nd Yes* age, race Yes*nd nd Yes* age, race Yes*nd nd Yes* age, race Yes*nd nd Yes* age, race Yes*Yes Yes Yes BMInd nd Yes/no* nd Yes/no* ndnd nd Yes/no* nd Yes/no* ndnd nd Yes/no* nd Yes/no* ndnd nd Yes/no* nd Yes/no* ndnd nd Yes No ndnd nd No nd No ndnd nd Yes* nd no* nd

nd Yes (Age) nd Yes (BMI) ndnd Yes (Age) nd Yes (BMI) ndnd Yes (Age) nd Yes (BMI) ndnd Yes - age nd Yes - BMI ndnd Yes - age nd Yes - BMI ndnd Yes - age nd Yes - BMI ndnd Yes - age nd Yes - BMI ndnd Yes - age nd Yes - BMI nd

nd nd nd ndnd nd nd ndnd nd nd nd

nd Yes (age) nd in some analysesnd Yes* - Age nd ndnd Yes* - Age nd nd

nd nd Yes/no* nd Yes/no* ndnd nd Yes/no* nd Yes/no* nd

K intake, total energy intakeNa intake, K intake, n-3 fa Na intake, K intake, n-3 fa Na intake, K intake, n-3 fa

Energy, fruit intakes Yes* age, sex,

educationNo significant interactions were No significant interactions were No significant interactions were No significant interactions were No significant interactions were No significant interactions were No significant interactions were No significant interactions were No significant interactions were changes in skin

pigmentationchanges in skin pigmentationchanges in skin pigmentationchanges in skin pigmentationchanges in skin pigmentationUse of Vit D

containing Age, sex, education (<12 y)

Matched on gender, adjusted

Yes (red meat consumption)Yes (red meat consumption)Yes (red meat consumption)Intakes of folate, calcium, retinol, Intakes of folate, calcium, retinol, Intakes of folate, calcium, retinol, Intakes of folate, calcium, retinol, Intakes of folate, calcium, retinol, Ca/placebo groups

similar age, Ca/placebo group similar BMICa/placebo groups

similar age, Ca/placebo group similar BMICa/placebo groups

similar age, Ca/placebo group similar BMIYes (total energy

intake)Yes (body mass index, fat and Baseline calcium

intake and vitamin Yes * - height, body weightBaseline calcium

intake and vitamin Yes * - height, body weight

History of diabetes nd nd nd nd ndHistory of diabetes nd nd nd nd nd

nd nd YesYes Yes Aspirin, Vitamin E nd ndYes Yes Aspirin, Vitamin E nd ndYes Yes Aspirin, Vitamin E nd ndnd nd nd nd nd ndYes nd nd nd ndnd nd nd nd nd nd- - - - - -nd nd nd nd nd ndYes nd nd nd ndYes nd nd nd nd- - - -- - - -

nd nd nd ndnd nd nd nd

nd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd Yes season of visitnd nd nd Yes seasonYes h/o outcomes No nd No ndYes h/o outcomes No nd No ndYes h/o outcomes No nd No ndYes h/o outcomes No nd No ndYes h/o outcomes No nd No ndnd nd nd nd nd ndnd nd nd nd nd ndNo nd No nd No ndNo nd No nd nd ndNo nd No ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndYes DM Yes No ndnd nd nd nd nd ndnd nd nd ndnd nd nd nd nd ndnd nd nd nd ndnd nd nd nd ndNo nd No nd Yes

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups

Systolic blood pressure, HDL

Treatment with gemfibrozil

time of sample retrievalDM,

HypercholesteroleDM, HypercholesteroleDM, Hypercholesterole

Hypercholesterolemia

HTN, hypercholesteroleHTN, hypercholesterole Season of blood

drawFor 25(OH)D analysis onlySeason of blood

drawFor 25(OH)D analysis onlyFamily of breast

cancer; benign Use of post menopausal Family of breast

cancer; benign Use of post menopausal

sample gestational age

Month commented on

Unclear if used in any analysisHistory of two or

more falls in past Never used hormones**History of two or

more falls in past Never used hormones**History of two or

more falls in past Never used hormones**

hormone replacement

Hormonal therapy, estrogen alone or

Latitude of the clinical center

Season of blood sample collectionSeason of blood sample collection Day of year

(matched)

No nd No nd YesNo nd No nd YesNo nd No nd No ndNo nd No nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd Physical activity ndnd nd nd Physical activity ndnd nd nd Physical activity ndnd nd nd Physical activity nd

nd nd No ndnd nd No ndnd nd No nd

nd nd nd nd nd ndYes Yes nd nd

nd No nd ndnd No nd ndnd No nd ndnd No nd ndnd No nd ndnd No nd ndnd No nd ndnd No nd ndnd nd nd nd

No nd No nd No ndNo nd nd nd Yes UVB exposureNo nd nd nd Yes UVB exposureNo nd nd nd Yes UVB exposureNo nd nd nd Yes UVB exposureNo nd nd nd Yes UVB exposurend nd nd nd ndnd nd nd nd nd nd- - - - -nd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd Yesnd nd nd nd Yes

Day of year (matched)Day of year (matched)

Use of HRT, duration of aspirin Use of HRT, duration of aspirin Use of HRT, duration of aspirin Use of HRT, duration of aspirin history of

menopausal or Non-steroidal anti-inflammatory history of

menopausal or Non-steroidal anti-inflammatory history of

menopausal or Non-steroidal anti-inflammatory

Family history of hypertension

Oral contraceptive use, creatinineYes (disease

history)Yes (season and location/latitude)Yes (disease







history)Yes (season and location/latitude)Menopausal

status, age at Hormonal replacement

Season of blood collection (for 25-

Month blood was taken

blood drawn in February in blood drawn in February in

nd nd nd nd Yesnd nd nd nd ndnd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd Yesnd nd nd nd nd ndNo nd No nd No ndnd nd nd Clinic site ndNo nd No nd ndNo nd No nd ndNo nd No nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndNo nd No nd No ndNo nd No nd No nd

nd No nd No ndNo nd No nd nd

nd Yes (aspirin) nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd HRT use nd Physical activity ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd

nd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No ndnd Yes (Aspirin) nd No nd

Yes DM, CHD Yes No ndYes DM, CHD Yes No ndYes DM, CHD Yes No ndYes DM, CHD Yes No nd

nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

blood drawn in February in Use of

nonsteroidal anti-Use of nonsteroidal anti-

UV exposure, location

Original treatment group (selenium Yes (geographical

region)Yes (geographical region)Yes (geographical region)

Yes (Hx of gallbladder Yes (place of

enrollment [i.e., Yes (family history of colon cancer,

Use of depomedroxyprogYes (family Hx, Hx

of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM)Yes (family Hx, Hx of DM) Alpha tocopherol

and beta caroteneAlpha tocopherol and beta caroteneAlpha tocopherol and beta caroteneAlpha tocopherol and beta caroteneHistory of benign

breast diseaseUse of oral contraceptives,

nd nd nd nd nd ndnd nd No ndnd nd No ndnd nd No nd

No nd Yes Yes physical activitynd nd nd nd No ndnd nd nd nd No ndnd nd nd nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndnd nd nd nd Yes spent time outsidend nd nd nd Yes spent time outsidend nd nd nd Yes spent time outsidend nd nd nd Yes spent time outsidend nd nd nd Yes spent time outsidend nd nd nd ndNo nd No nd No ndNo nd No nd No nd

nd nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd Yes seasonnd nd nd nd nd ndnd nd nd nd nd nd

nd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd Season ndnd nd Season ndnd nd Season ndnd nd Season nd

Yes Yes Hormonal use No ndYes type 2 DM nd nd nd ndnd parity nd nd ndnd parity nd nd ndnd parity nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

Yes (family history, polyps)

Yes (hormone replacement Yes (family

history, polyps)Yes (hormone replacement Yes (family

history, polyps)Yes (hormone replacement hormone therapy

in

Blood pressure, hypertensive

Self reported history of polyps

Regular use of aspirin in the

Yes (family CRC history)

Yes (for women only: HRT use )Yes (family CRC

history)Yes (for women only: HRT use )Yes (family CRC

history)Yes (for women only: HRT use )Yes (family CRC

history)Yes (for women only: HRT use )HTN, history of

CVD, diabetesUse of cholesterol-lowering HTN, history of



CVD, diabetesUse of cholesterol-lowering Menopausal status

at the time of

season of blood drawnseason of blood drawnseason of blood drawn

nd nd nd nd YesNo nd No nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd nd

nd nd nd Physical exercise ndnd nd nd Physical exercise ndnd nd nd Physical exercise nd

nd nd nd nd ndYes DM; PSA screen nd nd nd nd

nd nd nd nd ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No ndnd nd No nd

nd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndNo nd No nd No ndNo nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndYes HTN nd nd nd ndillness severity nd No nd No nd

Summer sun exposureYes, all from

HawaiiPostmenopausal hormone use, 1st trimester SBP;

parity1st trimester SBP; parityFamily Hx of

colorectal cancerFamily Hx of colorectal cancerFamily Hx of colorectal cancer Use of

nonsteroidal anti-

Family history of prostate cancerYes (family history of cancer, history

Yes (antacid use, menopausal Yes (family history

of cancer, history Yes (antacid use, menopausal Yes (family history
























of cancer, history Yes (antacid use, menopausal

Yes: Aspirin use, 1990

Yes: physical activity

No nd No nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

nd nd nd nd ndnd No nd No ndnd No nd No ndnd No nd No nd

History of DM nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd ndNo nd No nd NoNo nd No nd Yes (residence) ndNo nd No nd Yes (residence) ndNo nd No nd Yes (residence) ndNo nd No nd Yes (residence) ndNo nd No nd Yes (residence) ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndnd nd nd nd nd ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndNo nd No nd No ndnd nd nd nd ndYes HTN, DM nd nd nd ndYes HTN, DM nd nd nd ndYes HTN, DM nd nd nd nd

History of benign breast disease, Yes (menopausal status, family Yes (menopausal status, family Yes (menopausal status, family Region of

residence (south,

Seasonal variation of 25(OH)D, and

Seasonal variation of 25(OH)D was Subgroup analyses based on

US region, rural/urban/suburb

Yes HTN, DM nd nd nd ndYes DM, HTN Yes nd ndYes DM, HTN Yes nd ndYes DM, HTN Yes nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

nd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd ndnd nd nd nd nd

nd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndYes DM Yes anti-HTNive Yesnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndYes Yes nd ndnd nd nd nd nd ndnd nd nd nd nd nd

nd nd No ndnd nd No ndnd nd No ndnd Aspirin use nd physical activity ndnd Aspirin use nd physical activity ndnd Aspirin use nd physical activity ndnd Aspirin use nd physical activity ndnd Aspirin use nd physical activity nd

nd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndNo nd nd No ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd ndnd nd nd nd nd nd

for hypercholesterolefor hypercholesterolefor hypercholesterole

History of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancerHistory of colorectal cancer

Season of blood draw Physical

Adjusted for DM, htn, heart disease,

Adjusted for use of htn meds

Yes (family history CRC; for NHS only:

Yes (aspirin use; for NHS only: post-Yes (family history

CRC; for NHS only: Yes (aspirin use; for NHS only: post-Yes (family history

CRC; for NHS only: Yes (aspirin use; for NHS only: post-Family history of

colorectal cancerFamily history of colorectal cancerFamily history of colorectal cancerFamily history of colorectal cancerFamily history of colorectal cancer

Yes (use of hormone

Yes study center ndYes study center ndYes Smoking ndYes Yes Family Hx of MIYes Yes Family Hx of MIYes Yes Family Hx of MINo nd nd ndYes nd ndYes/no* nd nd ndYes EtOH - -Yes EtOH nd ndYes ndYes ndno* - -no* - -

nd ndnd nd

no* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndNo nd No ndNo nd No ndNo nd No ndNo nd No ndNo nd No nd

nd ndnd nd

no* nd No ndNo nd nd ndNo nd ndYes* Current smoker** ndYes* Current smoker** ndYes* Current smoker** ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndYes Smoking, exercise nd nd

nd ndYes nd nd ndYes* physical activity nd ndNo nd ndNo nd ndNo nd No nd

Confounder Groups

Confounder Groups

Confounder Groups

Confounder Groups Vigorous physical

activityVigorous physical activity Time of sample

retrieval Smoking, EtOH, Physical activitySmoking, EtOH, Physical activitySmoking, EtOH, Physical activity

Physical activity, EtOH, smoking

Smoking, EtOH, physical activity

Parental early MI, professionSmoking, EtOH,

physical activityParental early MI, professionTreatment

(calcium Treatment (calcium Yes (intakes of

alcohol)Parity; age at first birthYes (intakes of

alcohol)Parity; age at first birth

Yes* (physical activity)

bone area; markers of bone Yes* (physical

activity)bone area; markers of bone

Severity of diseaseTreatment arm in the hormone Treatment arm in the hormone Treatment arm in the hormone

Yes* - Smoking, exercise

Randomized treatment in the

Year of recruitment, Year of recruitment,

No nd No ndNo nd No ndNo nd nd ndNo nd nd ndYes EtOH nd ndYes EtOH nd ndNo nd 25(OH)D ndNo nd 25(OH)D ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd nd

nd ndnd ndnd ndnd ndnd nd ndnd nd ndnd nd nd

Yes ndYes* Physical activity Yes

ndndndndndndndnd

nd ndnd nd nd

no* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndYes Smoking (match) nd nd

nd nd ndNo - - -No nd nd ndNo nd nd ndno* nd ndno* nd ndYes/no* nd nd ndYes/no* nd nd nd

Yes - pack years of smoking, alcohol

Family history of colorectal cancer, Yes - pack years of

smoking, alcoholFamily history of colorectal cancer, Yes - pack years of

smoking, alcoholFamily history of colorectal cancer, Yes - pack years of

smoking, alcoholFamily history of colorectal cancer, smoking

(ever/never), smoking (ever/never), smoking (ever/never), Physical activity

was included in all Family hx of HTN, smoking status, Date of blood sample Yes (smoking

pattern)Never, former, current (<20pack-

Levels of physical activityYes (smoking














Levels of physical activityYes smoking

status, alcohol Months of the blood draw, Yes (smoking

[current/ex-/never

Yes (Cigarette consumption,

Center, follow-up time, number of Center, follow-up time, number of

Yes/no* nd nd ndYes/no* nd ndYes/no* nd ndNo nd nd ndNo nd nd ndno* nd nd ndNo nd nd ndno* nd nd ndYes nd nd

nd ndnd ndnd nd

no* nd nd ndno* nd nd ndno* nd nd ndNo nd ndNo nd ndYes (smoking) nd ndNo nd nd nd

nd nd ndnd ndnd ndnd nd

Yes ndYes ndYes physical activity nd ndYes physical activity nd ndYes physical activity nd ndno* nd nd ndYes nd

nd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd nd

Yes YesYes YesYes YesYes YesYes alcohol ndYes ndNo nd nd ndNo nd nd nd

Intervention assignment, Intervention assignment,

Cigarette smoking- pack Yes (smoking,

occupation)Cancer during the first-year f/u Yes (smoking,

occupation)Cancer during the first-year f/u Yes (smoking,

occupation)Cancer during the first-year f/u

The studied women were The studied women were Family history of colorectal cancer

Yes (smoking, alcohol, physical Yes - smoking, physical activity

Family hx of colon cancerYes - smoking,

physical activity Family hx of colon cancerYes (total alcohol

intake, smoking)Family hx of breast cancersmoking, alcohol,

physical activitypaternal hx of prostate cancerSmoking status,

drinking frequencyArea, marital status

exercise sessions/wk (high

Menses during trainingYes (exercise,

smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcoholYes (exercise, smoking, alcohol # cigarettes,

physical activity, BP, total cholesterol, HDL# cigarettes,



physical activity, BP, total cholesterol, HDLAge at first birth,

age at menarche, Smoking status (matched),

Follow-up period (matched)

No nd nd ndnd ndnd ndnd nd

Yes YesNo nd nd ndNo nd nd ndNo nd nd ndNo nd ndNo nd ndNo nd ndNo nd nd ndNo nd nd ndNo nd nd ndNo nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndno* nd nd ndYes* nd 25(OH)vitDYes Smoking YesYes Smoking YesNo nd ndNo nd nd ndNo nd nd ndNo nd nd ndNo nd nd ndNo nd nd ndNo nd nd nd

nd nd ndnd nd ndnd nd ndnd nd nd

Yes ndYes ndYes ndYes ndYes Smoking status YesYes YesYes smoking nd ndYes smoking nd ndYes smoking nd ndYes smoking ndNo nd nd nd


Yes (physical activity, smoking,

Yes (RCT arms [aspirin/no, Vit Yes (physical

activity, smoking, Yes (RCT arms [aspirin/no, Vit Yes (physical

activity, smoking, Yes (RCT arms [aspirin/no, Vit smoking status,

alcohol family history of breast cancer in a

Residential home, nursing or dual-Residential home, nursing or dual-Residential home, nursing or dual-

Physical activity, smoking, alcohol Functional

capacity (Vit D Functional capacity (Vit D Number of

colonoscopies

Yes (smoking; exercise METs)Yes (smoking; exercise METs)Yes (smoking; exercise METs)Yes (smoking; exercise METs) Smoking, physical

activity levelHDL, total cholesterol, Smoking, physical



activity levelHDL, total cholesterol, Mammographic

viewphysical activity; smoke inhalation,

FH of prostate cancer; marital

health insurance coverage

Yes groups matched on Yes groups matched on Yes groups matched on

no* nd Yes Baseline 25(OH)Dnd nd ndnd nd

No nd nd ndNo nd nd nd

nd ndnd ndnd ndnd nd nd

Yes YesYes Smoking nd

nd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status ndnd marital status nd

No nd ndNo nd ndNo nd nd

nd nd ndnd nd nd

No nd nd ndNo nd nd ndNo nd ndNo nd nd ndYes Cigarettes, alcohol YesNo nd nd

Yes (smoking; alcohol use)Yes - pack years of smoking,

Family history of colorectal cancer,

Yes - smoking, alcohol

Family history of colorectal cancer, Yes - smoking,

alcoholFamily history of colorectal cancer, Yes - smoking,

alcoholFamily history of colorectal cancer, Yes - smoking,

family history of physical activity; smoking; alcohol

marital status; FH prostate cancerTime since cohort

entryYes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Yes (vigorous physical activity, Both tx groups

were comparable Both tx groups were comparable Both tx groups were comparable Yes [smoking

years (<35 vs. Yes - smoking, alcohol

Family history of prostate cancer in

Education, marital statusserum PTH,

albumin,

No nd YesNo nd ndNo nd ndNo nd nd

nd ndnd nd ndnd nd ndnd nd nd

Yes smoking ndNo nd nd ndNo nd nd ndNo nd nd nd


Yes* smoking nd ndYes/no No nd

nd ndnd ndnd ndnd ndnd ndnd nd ndnd nd ndnd nd ndnd nd ndnd nd nd

No nd nd ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndNo nd None ndYes nd ndYes Smoking, EtOH nd ndYes Smoking, EtOH nd ndYes Smoking, EtOH nd nd

Adjusted for family hx of NS diff in %

smokers between NS diff in % smokers between NS diff in % smokers between Yes - physical

activity, alcohol Time period, parity, age at first Yes (cigarette

smoking, alcohol Yes (cigarette smoking, alcohol Yes (cigarette smoking, alcohol Parity (for women

only)

Yes 3 groups matched on % Yes 3 groups matched on % Yes 3 groups matched on %

smoking intensity and duration, Yes (physical

activity, marital Yes (Tx allocation of alpha-Yes (physical




activity, marital Yes (Tx allocation of alpha-Yes (alcohol

consumption)Yes (alcohol consumption)Yes (alcohol consumption)Yes (alcohol consumption)Yes (alcohol consumption)

Smoking status, current alcohol

Yes Smoking, EtOH nd ndYes Smoking, EtOH Yes MenopauseYes Smoking, EtOH Yes MenopauseYes Smoking, EtOH Yes MenopauseNo nd nd ndYes/no* nd nd nd

nd nd ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes nd Clinical center ndYes* outdoor activities nd ndYes* outdoor activities nd ndYes* outdoor activities nd ndYes* outdoor activities nd ndYes* outdoor activities nd ndYes Smoking YesYes/no* nd nd ndYes/no* nd nd ndYes/no* nd nd ndYes/no* nd nd ndYes nd ndNo nd nd ndno* nd nd nd

nd nd ndnd nd ndnd nd ndnd ndnd ndnd ndnd ndnd nd


nd ndYes/no* nd VitD status ndYes/no* nd VitD status ndYes/no* nd nd ndYes/no* nd nd nd

Yes* frailty indicators and

SBP, TC/HDL, SCr, (CRP, analysis not

Matched on smoking hx, EtOH

Yes (physical activity; pack-Yes (physical activity; pack-Yes (physical activity; pack-Yes - smoking, alcohol intake

Fasting status, month of blood Yes - smoking,

alcohol intakeFasting status, month of blood Yes - smoking,



alcohol intakeFasting status, month of blood Ca/placebo groups

similar % current Ca/placebo groups similar % current Ca/placebo groups similar % current Yes (smoking

status, pack-years in some analyses also: alcohol


Last Updated























6466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 18410225




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pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Intakes of calcium and vitamin D and risk of






vitamin D and breast Lin J., Manson JE., Lee IM., Cook NR., Buring JE., Intakes of calcium and























200720072007200720072007200720072007200720071986198619861986198619861986198619861986198619861986198619862008200820082008200820082005200520052005200520052005200520052005200220022002200219871987

Preventing fractures among older people living

Lyons RA., Johansen A., Brophy S., Newcombe RG., Preventing fractures










































risk of adenoma Martínez ME., Marshall JR., Sampliner R., Wilkinson J., Calcium, vitamin D, and




vitamin D supplementation Marya RK., Rathee S., Manrow M.Effect of calcium and

vitamin D supplementation Marya RK., Rathee S., Manrow M.

1988198819881988198819882006200620062006200620061981198119811981200320032003200320032008200820082008200820082008200820082008200620062006200620062006200620062006200620062006200120012006 Moschonis G., Manios Y.2006 Moschonis G., Manios Y.2006 Moschonis G., Manios Y.

Effect of vitamin D supplementation during

Marya RK., Rathee S., Dua V., Sangwan K.Effect of vitamin D




















products, and risk of McCullough ML., Robertson AS., Rodriguez Dietary calcium and

vitamin D intakes in Mishra G., McCormack V., Kuh D., Hardy R., Stephen Dietary calcium and






















hypertensive disorders of Morris CD., Jacobson SL., Anand R., Ewell MG., Nutrient intake and


response of bone mineral Skeletal site-dependent response of bone mineral Skeletal site-dependent response of bone mineral

200920092009200920092009200920092009200920092009200920092009200920092009200920092009200919981998200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007

A double-blind, randomized, placebo-





















microg/d cholecalciferol Nelson ML., Blum JM., Hollis BW., Rosen C., Supplements of 20


metabolite levels and the Nomura AM., Stemmermann GN., Lee J., Serum vitamin D


intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.Calcium and vitamin D














intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.Plasma vitamin D and risk










200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720012001200120012001200119991999199919992000

Plasma vitamin D and risk of colorectal cancer: the

Otani T., Iwasaki M., Sasazuki S., Inoue M., Plasma vitamin D and risk















intake and risk of Park SY., Murphy SP., Wilkens LR., Nomura AM., Calcium and vitamin D










risk of incident and fatal Park Y., Mitrou PN., Kipnis V., Hollenbeck A., Calcium, dairy foods, and


dairy product intake and Park SY., Murphy SP., Wilkens LR., Stram DO., Calcium, vitamin D, and









dairy product intake and Park SY., Murphy SP., Wilkens LR., Stram DO., Effects of a short-term







cancer in a cohort of Pietinen P., Malila N., Virtanen M., Hartman TJ., Diet and risk of colorectal





200020002000200020002000200020002000200020002000200020002000200020002000200020002000200020002000200020002000200520052005200520052005200520032003200320032003200720072007199719971997199519951995

Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D

Platz EA., Hankinson SE., Hollis BW., Colditz GA., Plasma 1,25-dihydroxy-

and 25-hydroxyvitamin D Platz EA., Hankinson SE., Hollis BW., Colditz GA., Plasma 1,25-dihydroxy-

































and risk of prostate cancer Rodriguez C., McCullough ML., Mondul AM., Jacobs Calcium, dairy products,





consumption and Rohrmann S., Platz EA., Kavanaugh CJ., Thuita L., Meat and dairy



dietary and other Ross RK., Yuan JM., Henderson BE., Park J., Prospective evaluation of


dietary and other Ross RK., Yuan JM., Henderson BE., Park J., Effect of winter oral




199519951995200620062006200620062006199319931993199319931993199319931993199319931993199319931993199319931993199319931993199319931993199319931993199319931993200820082008200820082008200920092009

Effect of winter oral vitamin D3

Scragg R., Khaw KT., Murphy S.Effect of winter oral


vitamin D3 Scragg R., Khaw KT., Murphy S.Dietary intake of calcium,











































of pancreatic cancer in the Stolzenberg-Solomon RZ., Hayes RB., Horst RL., Serum vitamin D and risk


of pancreatic cancer in the Stolzenberg-Solomon RZ., Hayes RB., Horst RL.,

200920092006200620062006200619971997199719971997199719971997199719971997199719971997199719971997199719971997199719971997199719971997199719971997199719971997198719872003200320032003200320032003

Serum vitamin D and risk of pancreatic cancer in the

Stolzenberg-Solomon RZ., Hayes RB., Horst RL., Serum vitamin D and risk


control study of vitamin D Stolzenberg-Solomon RZ., Vieth R., Azad A., Pietinen A prospective nested case-




































metabolites and the Tangrea J., Helzlsouer K., Pietinen P., Taylor P., Hollis Dietary calcium intake and

blood pressure in Thomsen K., Nilas L., Christiansen C.Dietary calcium intake and









200320032003200320032003200320032003200320032003200320032003200320032003200320032003200320032008200820082008200820082008200820082008198619861986198620062006200620062006200620062006200620062006

Effect of four monthly oral vitamin D3

Trivedi DP., Doll R., Khaw KT.Effect of four monthly oral






















vitamin D3 Trivedi DP., Doll R., Khaw KT.Dietary calcium intake and














pressure: a controlled van Beresteyn EC., Schaafsma G., de Waard Low serum concentrations












200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062008200820082008200819961996199619961996


Wactawski-Wende J., Kotchen JM., Anderson GL., Calcium plus vitamin D






































risk of cardiovascular Wang TJ., Pencina MJ., Booth SL., Jacques PF., Vitamin D deficiency and










199619961996199619961996199619961996200820082008199719971997199720022002200220072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007

Effect of longterm placebo controlled calcium

Weisgerber UM., Boeing H., Owen RW., Waldherr Effect of longterm placebo









related to folate status or Weng LC., Yeh WT., Bai CH., Chen HJ., Chuang SY., Is ischemic stroke risk






nonpharmacologic Whelton PK., Kumanyika SK., Cook NR., Cutler JA., Calcium intake and risk of

































1995199519951995199519951995199519951995199819981998200820082008200820082008200820082008200820082008200820082008200820082008

Lack of blood pressure effect with calcium and

Yamamoto ME., Applegate WB., Klag MJ., Borhani NO., Lack of blood pressure










of intake of calcium, Zheng W., Anderson KE., Kushi LH., Sellers TA., A prospective cohort study





















Outcome Units Subgroup TimepointCategorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)

kg Continuous N/A (years)kg Continuous N/A (years)

Categorical 2 (years)Categorical 2 (years)Categorical 2 (years)Categorical 2 (years)Categorical 2 (years)Continuous GirlsContinuous GirlsContinuous GirlsContinuous WomenContinuous WomenContinuous WomenContinuous Men

Outcome Type

Outcome DescriptionProstate

cancer All Participants Prostate




cancer All Participants Aggressive

prostate Gleason sum >=7 or

All Participants Aggressive








All Participants Prostate





cancer in All Participants Prostate



cancer in All Participants IHD (fatal +

nonfatal) Implied combinatio

All Participants IHD (fatal +








All Participants Nonfatal MI

[Self-Self-reporting









All Participants Fatal IHD

[Including Including sudden









All Participants Body

weight Change in kg/yr

All ParticipantsBody

weight Change in kg/yr

All ParticipantsHTN,

incident Physician diagnosis

All Participants HTN,








All Participants 25(OH)D

[ContinuousEnter a numeric 25(OH)D






[ContinuousEnter a numeric

Continuous MenContinuous MenContinuous WomenContinuous WomenContinuous WomenContinuous MenContinuous MenContinuous MenContinuousContinuousContinuousContinuous GirlsContinuous GirlsContinuous GirlsCategorical 1Categorical 1Categorical 1Categorical 1Categorical 1Categorical 1 Age<=50Categorical 1 Age<=50Categorical 1 Age<=50Categorical 1 Age >50Categorical 1 Age >50Categorical 1 Age >50CategoricalCategoricalCategoricalCategoricalCategoricalCategorical Stroke N/A (years)Categorical Stroke N/A (years)Categorical Stroke N/A (years)Categorical Stroke N/A (years)Categorical Stroke N/A (years)Categorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical N/A (years)Categorical N/A (years)

25(OH)D [Continuous

Enter a numeric 25(OH)D

[ContinuousEnter a numeric BMD -

lumbar DXA, whole body, or

Enter a numeric BMD -










Enter a numeric BMC -

whole body DXA, whole body, or

All Participants



All Participants



All Participants







Enter a numeric Incident

HTN All Participants










HTN Enter a numeric Incident





HTN Enter a numeric Hypertensi

on All Participants

Enter a numeric Hypertensi

on All Participants


on All Participants


on All Participants


on All Participants

Enter a numeric specific

stroke not extractedspecific




stroke not extractedProstate

cancer risk All Participants

Enter a numeric Prostate
















Enter a numeric Total serum

PSA All Participants

Enter a numeric Total serum

PSA All Participants

Enter a numeric Breast

cancer risk Risk of developing

All ParticipantsBreast


All Participants

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

nmol/l Continuous N/A (years)nmol/l Continuous N/A (years)nmol/l Continuous N/A (years)

Continuous All cause N/A (years)Continuous All cause N/A (years)

nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)

Categorical 30 (weeks)Categorical 30 (weeks)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

mg/cm2 Continuous N/A (years)mg/cm2 Continuous N/A (years)ug/L Continuous N/A (years)ug/L Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous N/A (years)Kg Continuous N/A (years)

Breast cancer risk

Risk of developing















All Participants25(OH)D

level Changes from


level Changes from


level Changes from

All ParticipantsMortality

[All All ParticipantsMortality

[All All Participants25(OH)D at

1 y All Participants25(OH)D at

1 y All Participantspreeclamps

ia gestational HTN &

All Participants preeclamps

ia gestational HTN &

All Participants Sudden

death Standard criteria

All ParticipantsSudden

death Standard criteria

All ParticipantsMI

[Standard Standard criteria

All ParticipantsMI


All ParticipantsStroke


All ParticipantsStroke


All ParticipantsCVD

Composite composite Adjudicated

All ParticipantsCVD

Composite composite Adjudicated

All ParticipantsFemoral

neck BMD DEXA of the femur was

All ParticipantsFemoral

neck BMD DEXA of the femur was


[Measured Measured at baseline


[Measured Measured at baseline

All ParticipantsWeight

[ContinuousAll ParticipantsWeight

[ContinuousAll ParticipantsColon

cancer State Health

All ParticipantsColon

cancer State Health


cancer State Health


cancer State Health


cancer State Health

All ParticipantsIHD death

[CategoricaAll ParticipantsIHD death



[CategoricaAll ParticipantsProstate

cancer Diagnosed 1980-1992,











All Participants Grip

strength Two measureme

Grip strength Grip


Grip strength

Kg Continuous N/A (years)Kg Continuous N/A (years)Counts Continuous N/A (years)Counts Continuous N/A (years)Counts Continuous N/A (years)Counts Continuous N/A (years)seconds Continuous N/A (years)seconds Continuous N/A (years)seconds Continuous N/A (years)seconds Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

m Continuous N/A (years)m Continuous N/A (years)

Categorical Fall N/A (years)Categorical Fall N/A (years)Categorical Fracture N/A (years)Categorical Fracture N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

g Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)g/cm2 Continuous areal BMD N/A (years)g/cm2 Continuous areal BMD N/A (years)g/cm2 Continuous areal BMD N/A (years)g/cm2 Continuous areal BMD N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)pmol/L Continuous 25(OH)D N/A (years)

Grip strength

Two measureme

Grip strength Grip


Grip strength Chair

stands Conducted if the

Chair stands Chair


Chair stands Chair


Chair stands Chair


Chair stands Timed walk

[The timed The timed walk

Timed walk (year 2)Timed walk






Timed walk (year 5)Muscle

strength Isometric quadriceps

Right quadriceps Muscle


Left quadriceps Muscle


Right hand grip Muscle


Left hand grip Fall [Fall

free Fall free survival

Fall free survival Fall [Fall






Fall free survival Twelve

minutes Twelve minutes Timed up

and go Timed up and goFall

[Defined as Defined as the patient Fall

[Defined as Defined as the patient fracture

[Any Any fracture fracture

[Any Any fracture Prostate

cancer Requested permission

Prostate cancerProstate






Prostate cancerIncident

invasive Confirmed by both

Invasive breast Incident










Total breast cancerIncident


Total breast cancerIncident


Death from breast Incident


Death from breast change in

BMC (ITT change in BMC (ITT change in



BMC (ITT change in BMC (ITT areal BMD

[Continuousareal BMD [Continuousareal BMD [Continuousareal BMD [ContinuousWeight change

Change in weight in

Body weightWeight

change Change in weight in

Body weight25(OH)D

[Continuous

pmol/L Continuous 25(OH)D N/A (years)pmol/L Continuous 1,25(OH)D N/A (years)pmol/L Continuous 1,25(OH)D N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical Survival N/A (years)Categorical Survival N/A (years)Categorical Survival N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous Weight N/A (years)Kg Continuous Weight N/A (years)Kg Continuous Weight N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)

25(OH)D [Continuous25(OH)D [Continuous25(OH)D [ContinuousAdenomas recurrence

nd (only for patients

Adenomas recurrenceAdenomas

recurrence nd (only for patients

Adenomas recurrenceSurvival [nd

(only for nd (only for patients Survival [nd

(only for nd (only for patients Survival [nd

(only for nd (only for patients HTN (Rx)

[HTN HTN medication

All Participants HTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), Age 40 yHTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), Age >40 yHTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), MaleHTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), FemaleHTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), BlackHTN (Rx)

[HTN HTN medication


[HTN HTN medication


[HTN HTN medication

HTN (Rx), WhiteHTN (Rx)

[HTN HTN medication

HTN (Rx), WhiteHTN (Rx)

[HTN HTN medication

HTN (Rx), WhiteHTN (BP or

Rx) [SBP SBP 160 or DBP 95

All Participants Weight [To

the nearest To the nearest 0.5 Weight [To

the nearest To the nearest 0.5 Weight [To

the nearest To the nearest 0.5 BMI

[ContinuousBMI [ContinuousBMI [Continuous25(OH)D [Continuous


[ContinuousAll Participants25(OH)D


[ContinuousPremenarcheal girls 25(OH)D

[ContinuousPremenarcheal girls 25(OH)D

[ContinuousPremenarcheal girls height

[ContinuousAll Participantsheight



[ContinuousPremenarcheal girls

cm Continuous N/A (years)cm Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)

Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

height [Continuous

Premenarcheal girls height

[ContinuousPremenarcheal girls Weight






[ContinuousPremenarcheal girls Total body

BMC All Participants Total body



BMC Premenarcheal girls Total body

BMC Premenarcheal girls Total body

BMC Premenarcheal girls 1,25(OH)D

[ContinuousAll Participants 1,25(OH)D

[ContinuousAll Participants 1,25(OH)D

[ContinuousAll Participants weight

[Continuousweight gain in North, weight






[Continuousweight gain in South, weight

[Continuousweight gain in south, weight


[Continuousweight gain in South, weight


[Continuousweight gain in south, length

[ContinuousLength gain in North, length






[ContinuousLength gain in South, length





[ContinuousLength gain in South, Colorectal

cancer Reported by a

All ParticipantsColorectal












All Participants

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)

Colorectal cancer

Reported by a





All ParticipantsProximal

vs. distal Same as above (not

Colorectal cancer Proximal










Rectal cancer Proximal










Colon cancer Proximal










Proximal colon Proximal










Distal colon cancer Proximal








Distal colon cancer Hypertensi

on [Self-Self-reported by

All ParticipantsHypertensi










All ParticipantsCancer

mortality Based on ICD-10











All ParticipantsLung cancer


All Participants Lung cancer






All Participants Digestive

cancer Based on ICD-10

All Participants Digestive


All Participants Breast




All Participants

Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

cm Continuous birth length N/A (years)cm Continuous birth length N/A (years)cm Continuous birth length N/A (years)cm Continuous birth length N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)cm Continuous 9 mo length N/A (years)cm Continuous 9 mo length N/A (years)cm Continuous 9 mo length N/A (years)cm Continuous 9 mo length N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Prostate cancer

Based on ICD-10



All Participants Non-

Hodgkin s Based on ICD-10

All Participants Non-

Hodgkin s Based on ICD-10

All Participants Colorectal






All Participants Other

cancers Based on ICD-10






cancer risk Incident breast

Incident breast Breast


















Incident breast birth length

[Continuousbirth length [Continuousbirth length [Continuousbirth length [Continuousbirth weight

birth weightbirth

weight birth weightbirth


weight birth weight9 mo length

[Continuous9 mo length [Continuous9 mo length [Continuous9 mo length [Continuous9 mo weight

9 mo weight9 mo

weight 9 mo weight9 mo

weight 9 mo weight9 mo

weight 9 mo weightatopic

eczema at 9 modified UK Working

atopic eczema at 9 atopic






atopic eczema at 9 Prostate

cancer Medical records and

Total prostate Prostate














Total prostate

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous Kg Weight N/A (years)Kg Continuous Kg Weight N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous DBP N/A (years)mm Hg Continuous DBP N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Colorectal cancer

Medical and hospital

Colorectal cancerColorectal

cancer Medical and hospital





Colorectal cancerColon

cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8


cancer ICD-8 153.0-153.8

All ParticipantsWeight

[Kg:ContinuWeight [Kg:ContinuSBP [ContinuousSBP [ContinuousDBP [ContinuousDBP [ContinuousAll adenomas

For each colonoscop

All adenomasAll

adenomas For each colonoscop

All adenomasAdvance

adenomas Advanced lesions

Advanced adenomasAdvance




Advanced AdenomasAdvance


Advanced Adenomas25(OH)D

total [sum sum of D2 and D3

change in total 25(OH)D






change in total 25(OH)D2

[Continuouschange in 25(OH)D2 25(OH)D2







[Continuouschange in 25(OH)D3 Recurrent

adenomas Ascertained by

Recurrent adenomasRecurrent








Recurrent adenomasAdvanced

adenomas Subjects had

Advanced adenomasAdvanced










Multiple recurrent


Kg Continuous N/A (years)Kg Continuous N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous DBP N/A (years)mm Hg Continuous DBP N/A (years)kg Continuous N/A (years)

Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

kg Continuous Weight N/A (years)kg Continuous Weight N/A (years)kg Continuous Weight N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Advanced adenomas

Subjects had

Multiple recurrent Advanced






Multiple recurrent Body

weight Change in bodyweight

Body weightBody

weight Change in bodyweight

Body weightSBP

[ContinuousSBP [ContinuousDBP [ContinuousDBP [ContinuousBody weight

Change in kg over 30

Body weightProstate

cancer Prostate cancerProstate





cancer Prostate cancerRectal

cancer Finish cancer

Colorectal cancer Rectal








Colon cancer Rectal


Colon cancer Rectal


Colon cancer Rectal


Colon cancer Rectal


Rectal cancer Rectal






Rectal cancer weight

[Analyzed Analyzed by a bipedal-weight

[Analyzed Analyzed by a bipedal-weight

[Analyzed Analyzed by a bipedal-BMI

[ContinuousBMI [ContinuousBMI [ContinuousColorectal cancer

Record linkage to

Colorectal cancer Colorectal

cancer Record linkage to








Cancer [Self Self reports (in the







Colorectal cancer Colon caner

[Response Response to the

Colon cancer Colon caner






Colon cancer

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

kg/m2 Continuous BMI N/A (years)kg/m2 Continuous BMI N/A (years)kg Continuous wt N/A (years)kg Continuous wt N/A (years)cm Continuous ht N/A (years)cm Continuous ht N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Colon caner [Response

Response to the

Colon cancer Colorectal

cancer Mostly diagnosed







Colorectal cancerIncident

breast Self reported

Breast cancerIncident








Breast cancer in Incident














Breast cancer in prostate

cancer self-reported of

prostate cancerprostate

cancer self-reported of

fatal prostate change in

BMI change in BMI change in wt change in wt change in ht change in ht incident cancer

from medical

incident cancer incident

cancer from medical


cancer from medical


cancer from medical


cancer from medical


cancer from medical

incident cancer change in

25 OH(D) change in 25 OH(D) change in

25 OH(D) change in 25 OH(D) change in

25 OH(D) change in 25 OH(D) stress

fractures Stress fractures

Stress fracture stress






Stress fracture Colorectal

caner National Swedish















Rectal cancer Distal colon


Colon cancer Distal colon


Colon cancer

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Distal colon caner

National Swedish



Colon cancer Colorectal
















Rectal cancer Distal colon








Colon cancer Cerebral

infarction Cerebral infarctionCerebral




infarction Cerebral infarctionInvasive

breast Linkage with

Invasive breast Invasive

breast Linkage with


breast Linkage with


breast Linkage with


breast Linkage with

Invasive breast Prostate

cancer Tumor Gleason





















Aggressive prostate Prostate


























Total prostate


ng/mL Continuous 25(OH)D N/A (years)ng/mL Continuous 25(OH)D N/A (years)pg/mL Continuous 1,25(OH)D N/A (years)pg/mL Continuous 1,25(OH)D N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)mm Hg Continuous N/A (years)


Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)Kg Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)mmol/L Continuous N/A (years)mmol/L Continuous N/A (years)mmol/L Continuous N/A (years)mmol/L Continuous N/A (years)

Categorical N/A (years)

Prostate cancer

Tumor Gleason















Aggressive prostate 25(OH)D

[CompetitivCompetitive protein 25(OH)D

[CompetitivCompetitive protein 1,25(OH)D

[RadiorecepRadioreceptor assay 1,25(OH)D

[RadiorecepRadioreceptor assay SBP

(standing) SBP (standing)SBP

(standing) SBP (standing)SBP

(standing) DBP (standing)SBP

(standing) DBP (standing)SBP

(standing) SBP (supine)SBP

(standing) SBP (supine)DBP

(supine) DBP (supine)DBP

(supine) DBP (supine)Distal colon

cancer [Not Not fully defined

Colorectal cancer Distal colon








Colorectal cancer Breast

cancer Incident cases of

Invasive breast Breast


















Invasive breast body

weight weight in medium body

weight weight in medium body

weight weight in low (<713 body

weight weight in low (<713 height

[Continuousheight in medium height

[Continuousheight in medium height

[Continuousheight in low (<713 height

[Continuousheight in low (<713 25(OH)D

[Continuous25(OH)D in medium 25(OH)D

[Continuous25(OH)D in medium 25(OH)D

[Continuous25(OH)D in low 25(OH)D

[Continuous25(OH)D in low First

fracture Confirmed by

First fracture (all

Categorical N/A (years)Categorical nd mortality N/A (years)Categorical nd mortality N/A (years)

Kg Continuous Kg Weight N/A (years)Kg Continuous Kg Weight N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)mmHg Continuous SBP N/A (years)mmHg Continuous SBP N/A (years)mmHg Continuous DBP N/A (years)mmHg Continuous DBP N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)pmol/L Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)

mmHg Continuous Systolic BP N/A (years)mmHg Continuous Systolic BP N/A (years)mmHg Continuous Diastolic BP N/A (years)mmHg Continuous Diastolic BP N/A (years)

Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical nd toxemia N/A (years)Categorical nd toxemia N/A (years)

First fracture

Confirmed by

First fracture (all Mortality

[nd:CategorMortality [nd:CategorWeight [Kg:ContinuWeight [Kg:ContinuBMI [ContinuousBMI [ContinuousSBP [ContinuousSBP [ContinuousDBP [ContinuousDBP [Continuousmaternal 25(OH)D at

maternal 25(OH)D at maternal

25(OH)D at maternal 25(OH)D at maternal

25(OH)D at maternal 25(OH)D at cord blood

1,25 cord 25(OH)Dcord blood



1,25 maternal 1,25(OH)2D cord blood



1,25 cord 1,25(OH)2D cord blood

1,25 cord 1,25(OH)2D cord blood

1,25 cord 1,25(OH)2D birth



weight birth weightHypertensi

on [Self-Self-report of

HypertensionHypertensi

on [Self-Self-report of

HypertensionSystolic BP

[ContinuousSystolic BP [ContinuousSystolic BP [ContinuousSystolic BP [ContinuousAMI [ICD 9 codes from

ICD 9 codes from AMI [ICD 9

codes from ICD 9 codes from AMI [ICD 9



codes from ICD 9 codes from Stroke

[Same:CateStroke [Same:CateStroke [Same:CateStroke [Same:CateStroke [Same:CateAdenoma recurrence

One or more

Adenoma recurrenceAdenoma

recurrence One or more





Adenoma recurrencetoxemia

[nd:Categortoxemia [nd:Categor

Kg Continuous N/A (years)Kg Continuous N/A (years)cm Categorical N/A (years)cm Categorical N/A (years)wk Continuous N/A (years)wk Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)g Continuous N/A (years)

Categorical CRC N/A (years)Categorical CRC N/A (years)Categorical CRC N/A (years)Categorical CRC N/A (years)Categorical CRC N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

g Continuous N/A (years)g Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)

g/cm2 Continuous DXA N/A (years)g/cm2 Continuous DXA N/A (years)g/cm2 Continuous DXA N/A (years)

newborn birth

newborn birth newborn

birth newborn birth crown-heel

length crown-heel lengthcrown-heel

length crown-heel lengthgestational

age gestational agegestational

age gestational age25(OH)D

[Continuous25(OH)D at 2 mo25(OH)D





[Continuous25(OH)D at 3 mobirth

weight maternal weight gain birth

weight maternal weight gain birth

weight infant birth weightbirth

weight infant birth weightCRC

[CategoricaCRC [CategoricaCRC [CategoricaCRC [CategoricaCRC [CategoricaMammography density

Ratio of the absolute

Mammographic Mammogra

phy density Ratio of the absolute

















Mammographic prostate

cancer Finnish Cancer

All Participantsprostate






All Participantsfatal

prostate All Participants fatal



prostate All Participants birth


weight birth weightcrown-heel

length crown-heel lengthcrown-heel

length crown-heel lengthpreeclamps

ia [HTN HTN (DBP 90 mm) and

preeclampsiaPregnancy-

induced Pregnancy-induced BMD

[DXA:ContiTotal body BMDBMD

[DXA:ContiTotal body BMDBMD

[DXA:ContiTotal body BMD

mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous DBP (ITT) N/A (years)mmHg Continuous DBP (ITT) N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous BMI (ITT) N/A (years)kg/m2 Continuous BMI (ITT) N/A (years)

Continuous N/A (years)Continuous N/A (years)

nmol/L Continuous 25(OH)D N/A (years)nmol/L Continuous 25(OH)D N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Men N/A (years)

SBP [Automated

Automated OMRON

SBP (ITT analysis)SBP

[Automated Automated OMRON

SBP (ITT analysis)SBP


SBP (per protocol SBP


SBP (per protocol DBP [Same

as Same as SBPDBP [Same


as Same as SBP

DBP (per protocol)DBP [Same

as Same as SBP

DBP (per protocol)25(OH)D

[Continuous25(OH)D (ITT)25(OH)D

[Continuous25(OH)D (ITT)25(OH)D

[Continuous25(OH)D (per 25(OH)D

[Continuous25(OH)D (per Weight

(ITT) Weight (ITT)Weight

(ITT) Weight (ITT)Weight

(ITT) Weight (per protocol)Weight

(ITT) Weight (per protocol)Weight

(ITT) Weight (ITT) BMI (per protocol)

BMI (per protocol)BMI (per

protocol) BMI (per protocol)Serum

25(OH)D Serum 25(OH)D prostate cancer

biopsy or surgical

prostate cancerprostate

cancer biopsy or surgical

prostate cancerColorectal

adenoma Reviewed the medical Colorectal




adenoma Reviewed the medical Distal colon

cancer Distal colon cancerDistal colon





cancer Rectum cancerDistal colon




cancer Rectum cancerColorectal

cancer Adenocarcinoma Colorectal







cancer Adenocarcinoma Colon

cancer [See See above (ICD180-

Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

mmHg Continuous SBP N/A (years)mmHg Continuous SBP N/A (years)mmHg Continuous DBP N/A (years)mmHg Continuous DBP N/A (years)nmol/L Continuous 25(OH)D N/A (years)nmol/L Continuous 25(OH)D N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Colon cancer [See

See above (ICD180-Colon

cancer [See See above (ICD180-Colon





cancer [See See above (ICD180-Rectal

cancer [See See above (ICD199 Rectal







cancer [See See above (ICD199 Colorectal

cancer Identified by means



















Colorectal cancer incident

prostate 8 state cancer

total prostate incident

prostate 8 state cancer

fatal prostate Prostate

cancer Identified by linkage



















Prostate cancerSBP

[Measured Measured after at SBP

[Measured Measured after at DBP [Same


as Same as SBP25(OH)D

[Continuous25(OH)D [ContinuousColon cancer or

Incident cases of


cancer or Incident cases of





Colorectal cancerDistal

colorectal Adenomatous polyps

All Participants

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous Kg, BMI Weight N/A (years)Kg Continuous Kg, BMI Weight N/A (years)kg/m2 Continuous BMI N/A (years)kg/m2 Continuous BMI N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous DBP N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Fatal stroke N/A (years)Categorical Fatal stroke N/A (years)Categorical Fatal stroke N/A (years)

mmHg Continuous SBP N/A (years)mmHg Continuous SBP N/A (years)

Continuous DBP N/A (years)

Distal colorectal

Adenomatous polyps

All Participants Distal












All Participants Rectal

adenoma Adenomatous polyps















All Participants Distal colon
















All Participants high-risk

distal colon Large (1 cm or larger),







All Participants Weight [Kg,

BMI:ContinWeight [Kg, BMI:ContinBMI [ContinuousBMI [ContinuousSBP [ContinuousSBP [ContinuousDBP [ContinuousProstate cancer

Incident cases


cancer Incident cases







Prostate cancerincident

prostate Cancer Registry;

incident prostate incident


incident prostate incident


incident prostate Fatal stroke

[CategoricaFatal stroke [CategoricaFatal stroke [CategoricaSBP [BP was

BP was measured SBP [BP

was BP was measured DBP [BP

was BP was measured

Continuous DBP N/A (years)ng/mL Continuous 25(OH)D N/A (years)ng/mL Continuous 25(OH)D N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

kg Continuous weight N/A (years)kg Continuous weight N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

DBP [BP was

BP was measured 25(OH)D

[As As measured 25(OH)D

[As As measured Colorectal

cancer Cohort members









Colorectal cancerPancreatic

cancer Self-reported

Pancreatic cancerCancer

mortality The residence

Gastrointestinal cancer Cancer


















Gastrointestinal cancer All-cause


All cause mortality All-cause










Total cancer All-cause




























Total cancer weight

[Continuousweight [ContinuousBMI [ContinuousBMI [ContinuousSerum 25(OH)D

Serum 25(OH)DSerum

25(OH)D Serum 25(OH)DPancreatic

cancer Vital status of cohort

Pancreatic cancerPancreatic




Pancreatic cancer

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)


Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Pancreatic cancer





cancer odds ratios (OR) for

pancreatic cancerPancreatic








Pancreatic cancerColorectal

cancer Diagnosis of primary
































cancer All Participants Colon







cancer All Participants Rectal












cancer All Participants Bodyweight

[Change in Change in kg/yr

Bodyweight changeBodyweight

[Change in Change in kg/yr

Bodyweight changeCerebrovas

cular same as above

Cardiovascular DiseaseCerebrovas

cular same as above

Cardiovascular DiseaseCerebrovas

cular same as above

Ischaemic Heart Cerebrovas

cular same as above

Ischaemic Heart Cerebrovas

cular same as above

Cerebrovascular Cerebrovas

cular same as above

Cerebrovascular Cerebrovas

cular same as above

IschaemicHeart

Categorical N/A (years)Categorical All Causes N/A (years)Categorical All Causes N/A (years)Categorical All Cancers N/A (years)Categorical All Cancers N/A (years)Categorical Colorectal N/A (years)Categorical Colorectal N/A (years)Categorical Respiratory N/A (years)Categorical Respiratory N/A (years)Categorical Breast N/A (years)Categorical Breast N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Respira-ry N/A (years)Categorical Respira-ry N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical CHD N/A (years)Categorical CHD N/A (years)Categorical CHD N/A (years)Categorical CHD N/A (years)Categorical CHD N/A (years)

Kg Continuous N/A (years)Kg Continuous N/A (years)Kg/m2 Continuous BMI N/A (years)Kg/m2 Continuous BMI N/A (years)

Categorical mortality N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Cerebrovascular

same as above

IschaemicHeart All cancers

incidence same as aboveAll cancers



incidence same as aboveColorectal

cancer same as aboveColorectal

cancer same as aboveRespiratory

cancer same as aboveRespiratory

cancer same as aboveBreast



cancer same as above

Cancer Excluding Breast


Cancer Excluding Breast


Colorectal CancerBreast


Colorectal CancerBreast


Respiratory CancerBreast


Respiratory CancerBreast


Breast CancerBreast


Breast CancerFalls

incidence same as above

Self Reported Falls

incidence same as above

Self Reported Respira-ry

[CategoricaRespira-ry [CategoricaFatal stroke [Death

Death certificates Fatal stroke

[Death Death certificates Fatal stroke



[Death Death certificates CHD

[CategoricaCHD [CategoricaCHD [CategoricaCHD [CategoricaCHD [CategoricaBody weight

Body weight in

Body weightBody

weight Body weight in

Body weightBMI

[ContinuousBMI [Continuousmortality [by death

by death certificateAll cause

mortality All cause mortalityAll cause

mortality All cause mortalityDeath from

colorectal Death from colorectal

Death from colorectal Death from

colorectal Death from colorectal

Death from colorectal Intestinal

polyps Intestinal polyps

Intestinal PolypIntestinal

polyps Intestinal polyps

Intestinal PolypKidney

stone Kidney stone

Kidney stone (UL)Kidney

stone Kidney stone

Kidney stone (UL)Cancer

related Kidney stone

Invasive colorectal Cancer


Invasive colorectal


ng/mL Continuous N/A (years)ng/mL Continuous N/A (years)

Continuous at 2 mo N/A (years)Continuous at 2 mo N/A (years)Continuous at 2 mo N/A (years)Continuous at 2 mo N/A (years)Continuous at 3 mo N/A (years)Continuous at 3 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 5 mo N/A (years)Continuous at 5 mo N/A (years)Continuous at 6 mo N/A (years)Continuous at 6 mo N/A (years)Continuous at 7 mo N/A (years)Continuous at 7 mo N/A (years)Continuous at 7 mo N/A (years)Continuous at 7 mo N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)

% change Continuous PI (total) N/A (years)% change Continuous PI (total) N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)

Cancer related

Kidney stone

Invasive colon Cancer


Invasive colon Cancer


Invasive rectal Cancer


Invasive rectal Cancer


Total cancerCancer


Total cancerCancer


Cancer mortalityCancer


Cancer mortalityvit D3 level

in mom mom 25 (OH)D at 1 vit D3 level

in mom mom 25 (OH)D at 1 at 2 mo

[Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuousat 2 mo [Continuous

mom vit D3 level at 1 at 2 mo

[Continuousmom vit D3 level at 1 at 2 mo

[Continuousantirachitic activity in at 2 mo

[Continuousantirachitic activity in at 2 mo

[Continuousinfant 25 (OH)D at 1 at 2 mo

[Continuousinfant 25 (OH)D at 1 at 2 mo

[Continuousinfant weight at 1 at 2 mo

[Continuousinfant weight at 1 at 2 mo

[Continuousinfant length at 1 at 2 mo

[Continuousinfant length at 1 First

cardiovascuMI, coronary First




cardiovascuMI, coronary PI [Change

in PI% of Change in PI% of each PI [Change


in PI% of Change in PI% of each

PI (highest compartmePI [Change


PI (highest compartmePI [Change


PI (lowest compartme

% change Continuous N/A (years)% change Continuous PI (curve) N/A (years)% change Continuous PI (curve) N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)

Categorical stroke N/A (years)Categorical stroke N/A (years)Categorical stroke N/A (years)

mm Hg Continuous SBP N/A (years)mm Hg Continuous SBP N/A (years)mm Hg Continuous DBP N/A (years)mm Hg Continuous DBP N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

PI [Change in PI% of

Change in PI% of each

PI (lowest compartmePI [Change


in PI% of Change in PI% of each Calcium

balance Total fecal calcium and

Total fecal calciumCalcium


Total fecal calciumCalcium


Water soluble Calcium


Water soluble Calcium


Total urine calciumCalcium


Total urine calciumstroke

[Self-Self-reported stroke

[Self-Self-reported stroke

[Self-Self-reported SBP

[ContinuousSBP [ContinuousDBP [ContinuousDBP [ContinuousPrimary adenocarcin

Reported as diagnosis of

All ParticipantsProximal

(right Colon cancer

All ParticipantsDistal (left

sided) Colon cancer


cancer [The The vast majority of










cancer All ParticipantsColon



cancer All ParticipantsProximal

colon All ParticipantsProximal



colon All ParticipantsDistal colon

cancer All ParticipantsDistal colon



cancer All ParticipantsRectal




cancer Colorectal cancer Rectal





cancer Colon cancer Rectal



cancer Colon cancer

mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)mmHg Continuous N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

nmol/liter Continuous 1 (years)nmol/liter Continuous 1 (years)nmol/liter Continuous 1 (years)nmol/liter Continuous 3 (years)nmol/liter Continuous 3 (years)nmol/liter Continuous 3 (years)nmol/liter Continuous 5 (years)nmol/liter Continuous 5 (years)nmol/liter Continuous 5 (years)mg/cm2 Continuousmg/cm2 Continuousmg/cm2 Continuousmg/cm2 Continuousmg/cm2 Continuousmg/cm2 Continuous N/A (years)mg/cm2 Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)

in SBP [Continuous

SBP in white in SBP

[ContinuousSBP in white in SBP



[ContinuousDBP in white in SBP



[ContinuousDBP in white BMI

[ContinuousAll ParticipantsBMI

[ContinuousAll ParticipantsRectal

cancer State Health

All ParticipantsRectal

cancer State Health

All ParticipantsRectal

cancer State Health


[Measured Measured by

















All ParticipantsBMD

[Measured Measured at the hip

All Participants

12 (months)BMD


All Participants

12 (months)BMD


All Participants

12 (months)BMD


All Participants

60 (months)BMD


All Participants

60 (months)BMD [Hip

and total Hip and total body.

All ParticipantsBMD [Hip

and total Hip and total body.



[ContinuousAll Participants

Armnd nd 119 157nd nd 125 156nd nd 190 157nd nd 167 156nd nd 148 155nd nd 73 156nd nd 130 157nd nd 105 156nd nd 90 155nd nd 68 157nd nd 34 144nd nd 26 148nd nd 41 143nd nd 48 131nd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd- 523 300 7960- 670 296 7960- 803 267 7960- 995 299 7960- 1377 296 7960- 523 212 7960- 670 206 7960- 803 197 7960- 995 220 7960- 1377 195 7960- 523 88 7960- 670 90 7960- 803 70 7960- 995 79 7960- 137 101 7960- - - -- - - -

Quintile 1 - - - -

Quintile 2 - - - -

Quintile 3 - - - -

Quintile 4 - - - -

Quintile 5 - - - -- - - -- - - -

Placebo - - - -- - - -- - - -

Placebo - - - -- - - -

Arm Description

Mean Vit D level/dose

Mean Ca level/dose

No. of Cases

No. of Non-casesquintiles

based on Quintile 2: 42.5-51.3 Quintile 3: 51.4-60.5 Quintile 4: 60.6-71.7 Quintile 5: 71.8-129.5 Quintile 2: 42.5-51.3 Quintile 3: 51.4-60.5 Quintile 4: 60.6-71.7 Quintile 5: 71.8-129.5 Serum 25(OH)D - Quartile cut off based Quartile 3: 25(OH)D = Quartile 2: 25(OH)D = Quartile 1: 25(OH)D = 25(OH)D - Group 1: 25(OH)D - Group 2: 25(OH)D - Group 1: 25(OH)D - Group 2: Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca supplementCalcium placebo

Vit D3 10 ug/dVit D3 20 ug/dVit D3 10 ug/dVit D3 20 ug/dVit D3 10 ug/d

- - - -

Placebo - - - -- - - -- - - -

Placebo - - - -- - - -- - - -

Placebo - - - -- - - -- - - -

Placebo - - - -- - - -- - - -

Placebo - - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -nd 500 75 ~8748 (64,728)nd 700 69 ~8748 (65,534)nd 800 51 ~8748 (64,596)nd 1000 63 ~8748 (64,425)nd 1400 70 ~8748 (64,112)- <675.2 nd nd- 675.2-990.8 nd nd- >990.8 nd nd- <25.2 ng/mL nd nd- 25.2-34 ng/mL nd nd- >34.0 ng/mL nd nd- <36.4 pg/mL nd nd- 36.4-47.08 pg/mL nd nd- >47.08 pg/mL nd nd- - - -

Placebo - - - -nd 159 138nd 149 141

Vit D3 20 ug/dVit D3 10 ug/dVit D3 20 ug/dVit D3 10 ug/dVit D3 20 ug/dVit D3 10 ug/dVit D3 20 ug/dVit D3 10 ug/dVit D3 20 ug/dCa intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Baseline dietary Ca Baseline dietary Ca Baseline dietary Ca Baseline 25(OH)D - Baseline 25(OH)D - Baseline 25(OH)D - Baseline 1,25(OH)2D Baseline 1,25(OH)2D Baseline 1,25(OH)2D Ca carbonate 25(OH)D - Quintile 1

20 ng/mL(1st batch) 28 (2nd 25(OH)D -

Quintile 221 to 28 29 to 34 19 to 24

nd 125 129nd 144 152nd 124 141

28.5 ng/mL nd 138 127nd 111 121

31.6 to 34.3 nd 117 12234.4 to 38.1 nd 123 12238.2 nd 129 126- - - -- - - -

Placebo - - - -1200 IU/day nd 10 73

Placebo 0 nd 9 68

Vit D + Ca - - - -

Placebo - - - -

Cases - - - -

Controls - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Calcium - - - -

Placebo - - - -

Quintile 1 nd <629 54 -

Quintile 2 nd 629-896 44 -

Quintile 3 nd 897-1188 42 -

Quintile 4 nd 1189-1547 44 -

Quintile 5 nd 1548- 28 -nd <696 127 ~8621.5 (74,224)nd 696-1051 84 ~8621.5 (74,497)nd 1052-1425 94 ~8621.5 (74,588)nd >1425 82 ~8621.5 (74,570)

Quintile 1 <24.1 nd - -

Quintile 2 24.1-29.5 nd - -

Quintile 3 29.6-35.4 nd - -

Quintile 4 35.5-41.3 nd - -

Quintile 5 >41.3 nd - -

Quintile 2-5 >24.1 nd - -

Placebo - - - -

Vit D + Ca - - - -


29 to 33 35 to 39 25 to 2925(OH)D -

Quintile 434 to 39 40 to 47 30 to 3625(OH)D -

Quintile 540 ng/mL 48 ng/mL 37 ng/mL25(OH)2D -

Quintile 125(OH)2D - Quintile 2

28.6 to 31.5 ng/mL25(OH)2D -

Quintile 325(OH)2D - Quintile 425(OH)2D - Quintile 5Cholecalciferol 400 Cholecalciferol 1200 Cholecalciferol 1200

Ca intake - Quartile 1Ca intake - Quartile 2Ca intake - Quartile 3Ca intake - Quartile 4

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -- - - -- - - -- - - -- - - -0 800 mg nd 240 800 mg nd 22400 IU 800 mg nd 24400 IU 800 mg nd 22- - - -- - - -

Vit D + Ca - - - -

Calcium - - - -

Vit D + Ca - - - -

Calcium - - - -nd 0-150 155 ndnd 151-300 206 ndnd 301-600 377 ndnd > 600 274 nd81.9 (13.2) nd CaD 86 Pl 76 19560.9 (3.5) nd CaD 95 Pl 86 18549.2 (3.3) nd CaD 102 Pl 92 17138.5 (3.3) nd CaD 71 Pl 102 17123.6 (5.9) nd CaD 94 Pl 91 176- - - -

Placebo - - - -- - - -

Placebo - - - -

Vit D + Ca - - - -- - - -- - - -

Placebo - - - -

Vit D + Ca - - - -- - - -- - - -

Placebo - - - -- - - -- - - -- - - -

No training + Ca, vit DNo training + Ca, vit DNo training + Ca, vit DNo training + Ca, vit DNo training + Ca, vit DTraining + CaNo training + Ca + Vit Training + + Ca + Vit No training + Ca, vit DNo training + Ca, vit D

Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Baseline 25(OH)D - Baseline 25(OH)D - Baseline 25(OH)D - Baseline 25(OH)D - Baseline 25(OH)D - Calcium carbonate Calcium carbonate

Ca + PlaceboDairy product

Ca + PlaceboDairy productCalcium, both weight Placebo, both weight Calcium, both weight

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Quartile 1 - - - -

Quartile 2 - - - -

Quartile 3 - - - -

Quartile 4 - - - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -

Quartile 2 - nd - -

Quartile 3 - nd - -

Quartile 4 - nd - -- - - -

High dairy - - - -- - - -

Control - - - -

High dairy - - - -- - - -

Control - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

Placebo, both weight Calcium, both weight Placebo, both weight Calcium carbonicumNo chemoprevCalcium carbonicum No chemoprevNo chemoprevCa intake, per 1 g/day

Ca intake, per 1 g/day Medium dairy

Medium dairy

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

Low Vit D - - - -

High Vit D - - - -

Placebo - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -

100 IU - - - -

200 IU - - - -

400 IU - - - -- - - 77- - - 79- - - 75- - - 77- - - 75- - - 77- - - 78

25(OH)D - Quintile 125(OH)D - Quintile 225(OH)D - Quintile 325(OH)D - Quintile 425(OH)D - Quintile 51,25(OH)2D - Quintile 11,25(OH)2D - Quintile 2

- - - 76- - - 76- - - 75

Quintile 1 17 <472 102 nd

Quintile 2 17 472-635 110 nd

Quintile 3 17 636-844 86 nd

Quintile 4 17 845-1270 106 nd

Quintile 5 17 >1270 80 nd

Quintile 1 17 <472 nd nd

Quintile 2 17 472-635 nd nd



Quintile 5 17 >1270 nd nd
















Quartile 1 - - - -

Quartile 2 - - - -

Quartile 3 - - - -

Quartile 4 - - - -

< 30.0 - - - -

>= 30.0 - - - -

6-Q1 - - - -

6-Q2 - - - -

6-Q3 - - - -

6-Q4 - - - -

6-Q5 - - - -

6-Q6 - - - -

4-Q1 - - - -

4-Q2 - - - -

4-Q3 - - - -

4-Q4 - - - -

2-Q1 - - - -

2-Q2 - - - -

2-Q1 - - - -

2-Q2 - - - -

1,25(OH)2D - Quintile 31,25(OH)2D - Quintile 41,25(OH)2D - Quintile 5

2-Q1 - - - -

2-Q2 - - - -

2-Q1 - - - -

2-Q2 - - - -

3-Q1 - - - -

3-Q2 - - - -

3-Q3 - - - -

3-Q1 - - - -

3-Q2 - - - -

3-Q3 - - - -25(OH)D 12 y 172 201025(OH)D 12 y 188 201025(OH)D 12 y 244 201025(OH)D 12 y 205 201025(OH)D 12 y 196 201025(OH)2D 12 y 166 201025(OH)2D 12 y 186 201025(OH)2D 12 y 206 201025(OH)2D 12 y 234 201025(OH)2D 12 y 212 2010- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -nd nd 9 440nd nd 10 440nd nd 15 440nd nd 14 440nd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd

Quintile 1: <18.3 Quintile 2: 18.3-<23.5 Quintile 3: 23.5-<28.3 Quintile 4: 28.3-<33.7 Quintile 5: >= 33.7 Quintile 1: <28.2 Quintile 2: 28.2-<33.5 Quintile 3: 33.5-<39 Quintile 4: 39-<46.3 Quintile 5: >= 46.3 Quartile 1:<30 Quartile 2: 30-50Quartile 3: >50-75Quartile 4: >75Quartile 1:<30 Quartile 2: 30-50Quartile 3: >50-75Quartile 4: >75Quartile 1:<30 Quartile 2: 30-50Quartile 3: >50-75Quartile 4: >75Quartile 1:<30 Quartile 2: 30-50Quartile 3: >50-75Quartile 4: >75Quartile 1:<30 Quartile 2: 30-50Quartile 3: >50-75Quartile 4: >75Quartile 1: 25-D 6.3-Quartile 2: 25-D 21.4-Quartile 3: 25-D 28.5-Quartile 4: 25-D 37.5-Quartile 1: 1,25-D Quartile 2: 1,25-D Quartile 3: 1,25-D Quartile 4: 1,25-D

nd 102-241 19 488nd 242-306 12 489nd 307-383 12 489nd 384-906 6 4584-19 - 9 820-26 - 7 1327-32 - 5 1833-41 - 4 1742-91 - 9 110-29 - - 42*****30 - - 57*****0-19 - - 17*****20 - - 82*****

Dairy diet - - - -- - - -

Dairy diet - - - -- - - -

Dairy diet - - - -- - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -nd < 666 mg/d 156 ndnd 666-814 163 ndnd 815-969 154 ndnd 970-1226 150 ndnd >1226 131 ndnd < 666 mg/d 23 ndnd 666-814 26 ndnd 815-969 22 ndnd 970-1226 23 ndnd >1226 21 ndnd < 666 mg/d 58 nd

Ca (mg/1000kcCa (mg/1000kcCa (mg/1000kcCa (mg/1000kc25(OH)D - Quintile 125(OH)D - Quintile 225(OH)D - Quintile 325(OH)D - Quintile 425(OH)D - Quintile 525(OH)D - Group 1 [0-25(OH)D - Group 2 25(OH)D - Group 1 [0-25(OH)D - Group 2 Dairy free dietDairy free dietDairy free diet

Vit D2 supplmentVit D2 supplmentVit D2 supplmentVit D2 supplmentVit D2 supplmentVit D2 supplmentCa intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1

nd 666-814 73 ndnd 815-969 71 ndnd 970-1226 69 ndnd >1226 47 nd- - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Vit D3 + Ca - - - -nd nd 26 58nd nd 33 49nd nd 24 59nd nd 27 56nd nd 29 54nd nd 27 56

Quartile 1 19.6 y 20 nd

Quartile 2 nd 19 nd

Quartile 3 nd 18 nd

Quartile 4 nd 15 nd


Quartile 2 nd 14 nd

Quartile 3 nd 9 nd

Quartile 4 nd 5 nd


Quartile 2 nd 5 nd

Quartile 3 nd 9 nd

Quartile 4 nd 10 nd

Placebo - - - -- - - -

Lactoval - - - -

Placebo - - - -- - - -

Lactoval - - - -

Quintile 1 39.6 596 98 623

Quintile 2 39.6 768 89 619

Quintile 3 39.6 893 87 622

Quintile 4 39.6 1032 81 627

Quintile 5 39.6 1288 88 620

Quartile 1 nd nd nd nd




Quintile 1 6 y <631 59 51343

Quintile 2 nd 631-765 32 51501

Quintile 3 nd 766-921 36 51127

Quintile 4 nd 922-1212 37 52047

Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5High dairy (high Ca)Control (low Ca)Ca supplement Ca supplement 1,25(OH)D - Tertile 1: 1,25(OH)D - Tertile 2: 1,25(OH)D - Tertile 3: 1,25(OH)D - Tertile 1: 1,25(OH)D - Tertile 2: 1,25(OH)D - Tertile 3: M: <1178.2 F:

<862.5M: 1178.2-1557.1 F: 862.5-1110.7M: 1557.2-1953.2 F: 1110.8-1416.6M: 1953.3- F: 1416.7-M: <1178.2 F: <862.5M: 1178.2-1557.1 F: 862.5-1110.7M: 1557.2-1953.2 F: 1110.8-1416.6M: 1953.3- F: 1416.7-M: <1178.2 F: <862.5M: 1178.2-1557.1 F: 862.5-1110.7M: 1557.2-1953.2 F: 1110.8-1416.6M: 1953.3- F: 1416.7-

Ca carbonate

Ca carbonate

Quintile 5 nd 1213- 39 51620nd <766.22 49 ndnd 766.22-962.63 47 ndnd 962.63-1201.81 39 ndnd > 1201.81 37 nd

Quartile 1 7.7 y <807 mg 32 3627

Quartile 2 7.7 y 807-960 mg 24 3627

Quartile 3 7.7 y 961-1144 mg 20 3627

Quartile 4 7.7 y >1144 mg 16 3627

Quartile 1 7.7 y <807 mg 14 nd

Quartile 2 7.7 y 807-960 mg 13 nd

Quartile 3 7.7 y 961-1144 mg 10 nd

Quartile 4 7.7 y >1144 mg 11 nd

Quartile 1 7.7 y <807 mg 18 nd

Quartile 2 7.7 y 807-960 mg 11 nd

Quartile 3 7.7 y 961-1144 mg 10 nd

Quartile 4 7.7 y >1144 mg 5 nd

Dairy Ca nd 0-199 mg/d 209 10011

Dairy Ca nd 0-199 mg/d 30 10011- - - -

Usual diet - - - -- - - -

Usual diet - - - -- - - -

Usual diet - - - -

Placebo nd nd 20 288

Calcium nd nd 17 445

Ca + Vit D nd nd 13 446

Placebo nd nd 16 266

Calcium nd nd 15 416

Ca + Vit D nd nd 6 403

Placebo - - - -

Calcium - - - -

Ca + Vit D - - - -

Ca + Vit D - - - -

Placebo - - - -

Ca + Vit D - - - -

Placebo - - - -

Quartile 1 80.4 <956 127 11348

Quartile 2 80.4 956-1179 111 11341

Quartile 3 80.4 1180-1444 107 11295

Quartile 4 80.4 1445- 104 11322

Quartile 1 80.4 <956 50 11348

Quartile 2 80.4 956-1179 49 11341

Quartile 3 80.4 1180-1444 37 11295

Quartile 4 80.4 1445- 37 11322

Quartile 1 80.4 <956 77 11348

Quartile 2 80.4 956-1179 62 11341

Ca intake - Quartile 1Ca Intake - Quartile 2Ca intake - Quartile 3Ca intake - Quartile 4

Ca enriched dietCa enriched dietCa enriched diet

Quartile 3 80.4 1180-1444 70 11295

Quartile 4 80.4 1445- 67 11322

Quartile 1 80.4 <956 127 11348

Quartile 2 80.4 956-1179 111 11341

Quartile 3 80.4 1180-1444 107 11295

Quartile 4 80.4 1445- 104 11322

Quartile 1 80.4 <956 50 11348

Quartile 2 80.4 956-1179 49 11341

Quartile 3 80.4 1180-1444 37 11295

Quartile 4 80.4 1445- 37 11322

Quartile 1 80.4 <956 77 11348

Quartile 2 80.4 956-1179 62 11341

Quartile 3 80.4 1180-1444 70 11295

Quartile 4 80.4 1445- 67 11322nd 876 518 ~5311nd 1178 541 ~5311nd 1379 542 ~5311nd 1581 546 ~5311nd 1916 555 ~5311nd nd 595 ndnd nd 595 ndnd nd 592 ndnd nd 571 ndnd nd 599 ndnd nd nd nd


Quartile 3 nd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd


Quartile 3 nd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd


Quartile 3 nd nd nd ndnd nd nd nd

Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1: Ca intake - Quintile 2: Ca intake - Quintile 3: Ca intake - Quintile 4: Ca intake - Quintile 5: Quartile 1: lowest

Quartile 4: highest Quartile 1: lowest Quartile 4: highest Low 25(OH)D, Low 25(OH)D, High 25(OH)D, High 25(OH)D, Quartile 1: lowest

Quartile 4: highest Quartile 1: lowest Quartile 4: highest Low 25(OH)D, Low 25(OH)D, High 25(OH)D, High 25(OH)D, Quartile 1: lowest

Quartile 4: highest

nd nd nd ndnd nd nd ndnd nd nd nd


Quartile 3 nd nd nd ndnd nd nd ndnd nd nd ndnd nd nd nd- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -

Quintile 1 nd <614 41 7691

Quintile 2 nd 614-<785 31 nd

Quintile 3 nd 785-<1016 52 7690

Quintile 4 nd 1016-<1357 41 nd

Quintile 5 nd 1357- 58 7690nd <617 70nd 617 to <789 65 ? 10578nd 789 to <1026 44 ? 10578nd 1026 to <1366 59 ? 10578nd 1366 38 ? 10578nd <617 104 ?20909nd 617 to <789 116 ?20909nd 789 to <1026 112 ?20909nd 1026 to <1366 119 ?20909nd 1366 151 ?20909

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Placebo - - - -

Quartile 1: lowest Quartile 4: highest Quartile 1: lowest

Quartile 4: highest Quartile 1: lowest Quartile 4: highest Ca supplementCa supplementCa supplementCa supplementCa supplementCa supplement

Ca intake - Quintile 1

? unclear what was used in Ca intake -

Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5

Vit D2 - - - -

Placebo - - - -

Vit D2 - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -10 y nd nd ~252nd nd nd ~252nd nd nd ~25210 y nd nd ~25210 y nd nd ~25210 y nd nd ~252nd nd nd ~252nd nd nd ~25210 y nd nd ~252nd nd nd ndnd < 778 178 148nd 778-996 175 151nd 997-1279 148 178nd >1279 138 188

Vit D + Ca - - - -

Placebo - - - -

unsupplementedVit D 1000 IU/dVit D 200,000 IU unsupplementedVit D 1000 IU/dVit D 200,000 IU unsupplementedVit D 1000 IU/dVit D 200,000 IU unsupplementedVit D 1000 IU/dVit D 200,000 IU unsupplementedVit D 1000 IU/dVit D 200,000 IU

Ca intake - Tertile 1Ca intake - Tertile 2Ca intake - Tertile 325(OH)D - Tertile 11,25(OH)2D - Tertile 1Ca intake - Tertile 1Ca intake - Tertile 2Ca intake - Tertile 325(OH)D - Tertile 11,25(OH)2D - Tertile 1Ca Intake - Quartile 1 Ca Intake - Quartile 2 Ca Intake - Quartile 3 Ca Intake - Quartile 4

- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -

Calcium - - - -- - - -- - - -

Calcium - - - -- - - -- - - -

calciferol - - - -

Placebo - - - -

calciferol - - - -

Placebo - - - -nd <561 156 ndnd 561-731 165 ndnd 732-925 137 ndnd 926-1255 108 ndnd >1255 117 nd

Quintile 1 nd 523 133 766

Quintile 2 nd 524 648 143 766

Quintile 3 nd 652 784 156 766

Quintile 4 nd 785 940 160 766



Quintile 2 nd 612-735 156 755

Quintile 3 nd 736-859 145 755

Quintile 4 nd 860-1020 156 755

Quintile 5 nd 1021 153 755- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Dietary Ca nd 579 nd nd

Dietary Ca nd 579 nd nd

Control - - - -- - - -

Dairy group - - - -

1.2 million IU vit D1.2 million IU vit D1.2 million IU vit D

Ca + 5000 D2Ca + 10000 D2Ca + 5000 D2Ca + 10000 D2

Ca intake - Quintile 1 Ca intake - Quintile 2 Ca intake - Quintile 3 Ca intake - Quintile 4 Ca intake - Quintile 5

Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - Dairy Ca intake - maternal vit D at 28->= 28 nmol/Lmaternal vit D at 28->= 28 nmol/L

Ca supplement

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D3 - - - -

Placebo - - - -nd 38 34

<33 pg/mL nd 42 40nd 584 nd ndnd 779 nd ndnd 949 nd ndnd 1139 nd ndnd 1451 nd ndnd 584 nd ndnd 779 nd ndnd 949 nd ndnd 1139 nd ndnd 1451 nd ndnd 584 nd ndnd 779 nd ndnd 949 nd ndnd 1139 nd ndnd 1451 nd nd<22.9 nd 43 7422.9-27.5 nd 40 8527.6-32.0 nd 36 8532.1+ nd 44 80<22.9 nd 41 7722.9-27.5 nd 34 7327.6-32.0 nd 44 7132.1+ nd 41 76<22.9 nd 25 54

25 OH-D, quartile of

<34 ng/mL (based on controls freq)1,25 OH-D,

quartile ofCa intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 525(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 1

22.9-27.5 nd 27 5527.6-32.0 nd 29 6632.1+ nd 38 62<22.9 nd 21 5322.9-27.5 nd 27 4827.6-32.0 nd 27 4132.1+ nd 31 53<22.9 nd 18 2022.9-27.5 nd 13 3027.6-32.0 nd 7 1932.1+ nd 6 18<22.9 nd 20 2422.9-27.5 nd 7 2527.6-32.0 nd 17 3032.1+ nd 10 23nd 342 ndnd 271 ndnd 258 ndnd 177 ndnd 90 ndnd 172 ndnd 175 ndnd 194 ndnd 197 ndnd 234 ndnd <500 mg/d 767 ndnd <500 mg/d 11 ndnd nd 706 ndnd nd 925 ndnd nd 949 ndnd nd 936 ndnd nd 888 ndnd nd 639 ndnd nd 938 ndnd nd 910 ndnd nd 940 ndnd nd 977 nd

Calcium - - - -

Vit D + Ca - - - -

Calcium - - - -

Vit D + Ca - - - -

Calcium - - - -

Vit D + Ca - - - -nd 856 60 ndnd 1241 41 ndnd 1484 45 ndnd 1789 39 nd22.3 pg/ml - - -

25(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 4Ca intake - Quintile 1

<288 mg/1000kcal/dCa intake -

Quintile 2288 -< 369 mg/1000kcal/dCa intake -



Quintile 5611 mg/1000kcal/dCa intake -

Quintile 1<288 mg/1000kcal/dCa intake -




Quintile 5611 mg/1000kcal/dCa intake

(diet + Ca intake (diet + Ca intake - Quintile 1: Ca intake - Quintile 2: Ca intake - Quintile 3: Ca intake - Quintile 4: Ca intake - Quintile 5: Vit D intake - Quintile 1: Vit D intake - Quintile 2: Vit D intake - Quintile 3: Vit D intake - Quintile 4: Vit D intake - Quintile 5:

Ca intake - Quartile 1, Ca intake - Quartile 2, Ca intake - Quartile 3, Ca intake - Quartile 4, 1,25(OH)2D - Quartile 2

29.0 pg/ml - - -33.9 pg/ml - - -40.9 pg/ml - - -16.3 pg/ml - - -22.6 pg/ml - - -28.3 pg/ml - - -38.0 pg/ml - - -22.3 pg/ml - - -29.0 pg/ml - - -33.9 pg/ml - - -40.9 pg/ml - - -16.3 pg/ml - - -22.6 pg/ml - - -28.3 pg/ml - - -38.0 pg/ml - - -22.3 pg/ml - - -29.0 pg/ml - - -33.9 pg/ml - - -40.9 pg/ml - - -16.3 pg/ml - - -22.6 pg/ml - - -28.3 pg/ml - - -38.0 pg/ml - - -16.3 - - -22.6 - - -28.3 - - -38.0 - - -

Placebo - - - -- - - -

Placebo - - - -- - - -

Placebo - - - -- - - -- - - -nd nd 1323 23,653nd nd 1293 ndnd nd 835 ndnd nd 265 ndnd nd 95 1,330

Tertile 1 nd <685.77 mg/d 58 nd

Tertile 2 nd 65 nd

Tertile 3 nd >957.58 mg/d 76 nd12 years nd 103 460nd nd 68 369nd nd 74 396

Placebo - - - -

Vit D - - - -

Placebo - - - -

1,25(OH)2D - Quartile 31,25(OH)2D - Quartile 41,25(OH)2D - Quartile 125(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 41,25(OH)2D - Quartile 21,25(OH)2D - Quartile 31,25(OH)2D - Quartile 41,25(OH)2D - Quartile 125(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 41,25(OH)2D - Quartile 21,25(OH)2D - Quartile 31,25(OH)2D - Quartile 41,25(OH)2D - Quartile 125(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 4Ca supplementCa supplementCa supplementCa supplementCa intake - Quintile 1: Ca intake - Quintile 2: Ca intake - Quintile 3: Ca intake - Quintile 4: Ca intake - Quintile 5:

685.77 to 957.58 mg/d

Ca intake - Tertile 1Ca intake - Tertile 2Ca intake - Tertile 3

Vit D - - - -

Placebo - - - -

Vit D - - - -nd 291.9 nd ndnd 389.9 nd ndnd 488.2 nd ndnd 610.8 nd ndnd > 610.8 nd ndnd <500 1728 yr 585 nd ndnd 585<, 725 nd ndnd 725<, 935 nd ndnd 935<, 1245 nd ndnd >1245 nd nd28 yr 445 nd ndnd 445<, 540 nd ndnd 540<, 640 nd ndnd 640<, 850 nd ndnd >850 nd nd28 yr 585 nd ndnd 585<, 725 nd ndnd 725<, 935 nd ndnd 935<, 1245 nd ndnd >1245 nd nd28 yr 585 232 (total cases) 1321 (total)nd 585<, 725 nd ndnd 725<, 935 nd ndnd 935<, 1245 nd ndnd >1245 nd nd28 yr 445 nd ndnd 445<, 540 nd ndnd 540<, 640 nd ndnd 640<, 850 nd ndnd >850 nd nd28 yr 445 127 (total cases) 1270 (total)nd 445<, 540 nd ndnd 540<, 640 nd ndnd 640<, 850 nd ndnd >850 nd nd- - - -- - - -- - - -- - - -- - - -- - - ->82.3 nd 42 73>45.9 and 60.3 - 40 74>60.3 and 69.5 - 27 73

Ca intake - Quintile 1, Ca intake - Quintile 2, Ca intake - Quintile 3, Ca intake - Quintile 4, Ca intake - Quintile 5, Total daily calcium

Person-year: 59,963Ca intake -

Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Vit D + Ca + placeboCa + placeboVit D + Ca + placeboCa + placeboVit D + Ca + placeboCa + placebo25(OH)D - Quintile 1: 25(OH)D - Quintile 2: 25(OH)D - Quintile 3:

>69.5 and 82.3 - 31 74>82.3 - 42 73

<32 Not Applicable Not Applicable 27 80nd nd 34 80nd nd 47 80nd nd 35 81

>65.5 nd nd 57 79-9.8 nd 46 72>9.8-13.9 nd 35 73>13.9-19.3 nd 36 73>19.3 nd 29 72-31.7 nd 32 72>31.7-37.3 nd 43 72>37.3-43.1 nd 41 74>43.1 nd 30 72-9.8 nd 30 47>9.8-13.9 nd 18 47>13.9-19.3 nd 22 45>19.3 nd 21 42-31.7 nd 20 51>31.7-37.3 nd 29 44>37.3-43.1 nd 20 41>43.1 nd 22 45-9.8 nd 19 38>9.8-13.9 nd 13 35>13.9-19.3 nd 19 32>19.3 nd 17 31-31.7 nd 12 21>31.7-37.3 nd 14 28>37.3-43.1 nd 21 33>43.1 nd 8 27-9.8 nd 16 25>9.8-13.9 nd 17 26>13.9-19.3 nd 14 28>19.3 nd 8 30-9.8 nd 12 15>9.8-13.9 nd 13 16>13.9-19.3 nd 7 21>19.3 nd 7 25

Calcium - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

25(OH)D - Quintile 4: 25(OH)D - Quintile 5: >32 and <41.1>41.1 and <51.1>51.1 and <65.525(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 41,25(OH)2D - Quartile 11,25(OH)2D - Quartile 21,25(OH)2D - Quartile 31,25(OH)2D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 41,25(OH)2D - Quartile 11,25(OH)2D - Quartile 21,25(OH)2D - Quartile 31,25(OH)2D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 41,25(OH)2D - Quartile 11,25(OH)2D - Quartile 21,25(OH)2D - Quartile 31,25(OH)2D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 4

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -

Vit D - - - -

Placebo - - - -nd 233 314 ~8305 (112,018)nd 344 257 ~8305 (106,354)nd 439 252 ~8305 (106,435)nd 603 247 ~8305 (104,697)nd 753 251 ~8305 (104,186)nd 233 72 ~8305 (112,018)nd 344 72 ~8305 (106,354)nd 439 56 ~8305 (106,435)nd 603 58 ~8305 (104,697)nd 753 64 ~8305 (104,186)

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -<25 nmol/L nd 66 127

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5Ca intake - Quintile 1Ca intake - Quintile 2Ca intake - Quintile 3Ca intake - Quintile 4Ca intake - Quintile 5

25(OH)D, published

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

Placebo - - - -

Vit D + Ca - - - -

mom 400 - - - -

mom 6400 - - - -

mom 400 - - - -

mom 6400 - - - -

infant 300 - - - -- - - -

mom 400 - - - -

mom 6400 - - - -

mom 400 - - - -

mom 6400 - - - -

infant 300 - - - -- - - -

mom 400 - - - -

mom 6400 - - - -

mom 400 - - - -

mom 6400 - - - -

mom 400 - - - -

mom 6400 - - - -

infant 300 - - - -- - - -

mom 400 - - - -

mom 6400 - - - -

mom 400 - - - -

mom 6400 - - - -

infant 300 - - - -- - - -

infant 300 - - - -- - - -

infant 300 - - - -- - - -<10 ng/mL nd nd nd

Deficiency 10-<15 ng/mL nd nd nd

Referent 15 ng/mL nd 70 1258- - - -- - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

infant placebo

infant placebo

infant placebo

infant placeboinfant placeboinfant placeboSevere deficiency

25(OH)D <15 ng/mL25(OH)D >= 15 ng/mL

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -

Calcium - - - -

Placebo - - - -nd >591.50 mg nd nd

Quartile 2 nd 451.24-591.50 mg nd nd

Quartile 1 nd <451.24 nd nd- - - -

Placebo - - - -- - - -

Placebo - - - -nd 500 47 ndnd 500 12 ndnd 500 22 nd18.4 nd 45 7125.0 nd 44 7129.1 nd 30 6833.3 nd 23 7439.4 nd 37 7219.3 nd 49 6626.7 nd 44 6832.0 nd 17 6838.8 nd 29 7419.3 nd 20 3026.7 nd 21 3632.0 nd 10 3538.8 nd 18 3519.3 nd 19 2726.7 nd 16 2232.0 nd 4 2138.8 nd 8 2421.2 nd 11 3029.3 nd 15 2837.4 nd 14 2218.4 nd 36 5825.0 nd 38 5529.1 nd 22 5633.3 nd 20 6039.4 nd 29 5919.3 nd 40 5526.7 nd 37 5232.0 nd 16 5938.8 nd 20 58

Quartile 3 + Quartile 4

Ca supplementCa supplementCa intake - Cumulative Ca intake - Cumulative Ca intake - Cumulative 25(OH)D - Quintile 125(OH)D - Quintile 225(OH)D - Quintile 325(OH)D - Quintile 425(OH)D - Quintile 525(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 425(OH)D - Tertile 125(OH)D - Tertile 225(OH)D - Tertile 325(OH)D - Quintile 125(OH)D - Quintile 225(OH)D - Quintile 325(OH)D - Quintile 425(OH)D - Quintile 525(OH)D - Quartile 125(OH)D - Quartile 225(OH)D - Quartile 325(OH)D - Quartile 4

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Calcium - - - -

Placebo - - - -nd <800.8 56 ndnd 800.8-1278.7 52 ndnd 1278.7 36 nd- - - -

Vit D + Ca - - - -

Placebo - - - -- - - -

Vit D + Ca - - - -

Placebo - - - -- - - -

Vit D + Ca - - - -

Placebo - - - -- - - -

Placebo - - - -

Vit D2 + Ca - - - -

Vit D + Ca - - - -

Placebo - - - -- - - -

Vit D2 + Ca - - - -- - - -

Vit D2 + Ca - - - -

Urinary Ca 20.3-124.9 Urinary Ca 125.0-169.0 Urinary Ca 169.1-235.9 Urinary Ca 236-606.4 Urinary Ca 20.3-124.9 Urinary Ca 125.0-169.0 Urinary Ca 169.1-235.9 Urinary Ca 236-606.4

Calcium intake - Calcium intake - Calcium intake - Ca + Placebo

Ca + Placebo

Ca + Placebo

Ca + Placebo

Ca + PlaceboCa + Placebo

Baseline- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -2.9 yrs 36 65.8 SD = 1.5 Delta = +0.1 nd2.9 yrs 28 65.6 SD = 1.8 Delta = +0.1 nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -12 9 / 7 8.8 - - -12 9 / 7 16.9 - - -12 8 / 7 7.3 - - -12 30 / 21 9.95 - - -12 30 / 22 14.0 - - -12 29 / 19 11.7 - - -12 26 / 19 22.9 - - -

Mean Follow-up,

No. Analyzed

Baseline CI / SE / SD*

Final or Delta**

Final or Delta CI /

12 31 / 26 18.9 - - -12 27 / 20 20 - - -12 30 / 21 1.06 - - -12 30 / 21 0.98 - - -12 29 / 18 0.99 - - -12 25 / 19 1.03 - - -12 31 / 26 0.92 - - -12 29 / 19 1.03 - - -nd 9 / 7 1308 - - -nd 8 / 7 1473 - - -12 8 / 7 1666 - - -12 9 / 7 1308 - - -12 9 / 7 1473 - - -12 8 / 7 1666 - - -4 y - - - - -4 y - - - - -4 y - - - - -4 y - - - - -4 y - - - - -4 y - - - - -4 y - - - - -4 y - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -48 263 1.72 2.93 +0.28 0.1948 279 1.88 2.52 +0.53 0.18- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- 60 nd nd - -- 63 nd nd - -- 59 nd nd - -- - - - - -- - - - - -1 y 132 74.7 33.8 +48.5 35.31 y 125 71.2 29.8 +9.3 21.5- 49 - - - -- 216 - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -24 56 nd nd +0.7 -10.2, 11.624 50 nd nd +1.9 -6.5, 10.324 56 22.8 6.1 19.5 5.324 50 25.0 6.2 Final: 29.8 SD: 6.01.25 10 78.1 9.1 80.0 3.21.25 10 78.1 9.1 79.6 3.0- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -24 months 1265 nd nd -1.27 5.3024 months 1334 nd nd -1.20 5.63

60 months 1162 22.96 5.75 -2.64 5.6960 months 1185 22.81 5.78 -2.49 5.8124 months 1188 nd nd -0.12 1.6024 months 1250 nd nd -0.09 1.5560 months 1053 6.63 1.82 -0.43 1.8160 months 1065 6.52 1.87 -0.38 1.8124 months 1238 nd nd +0.23 6.3824 months 1298 nd nd +0.11 7.0860 months 1141 6.19 4.64 +0.81 6.4360 months 1160 6.5 5.51 +0.26 6.289 months 24 21.2 6.7 19.6 6.89 months 24 19.6 4.9 17.4 5.39 months 24 21.7 6.8 20.6 5.39 months 24 20.3 6.5 18.2 5.3- - - - - -- - - - - -- - - - - -- - - - - -9 months 24 739.3 159.8 859.7 110.19 months 24 11.4 2.0 13.8 2.5

- - - - -- - - - -- - - - -- - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -7 y - - - - -nd - - - - -7 y - - - - -nd - - - - -- 46 1328 292 - -- 41 1431 274 - -- 39 1343 235 - -- 39 1383 257 - -- 46 0.934 0.1 - -- 41 0.945 0.1 - -- 39 0.935 0.1 - -- 39 0.939 0.1 - -6 weeks 10 16 70.9 71.5 5.1 5.8 70.9 67.9 5.5 5.76 weeks 15 16 68.0 74.5 7.7 7.3 68.4 71.2 7.5 7.16 weeks 10 16 81.4 74.1 14.6 22.0 80.1 76.9 16.2 18.2

Median 30 days (IQR 14.75 Median 30 days (IQR 14.75 Median 30 days (IQR 14.75 Median 30 days (IQR 14.75

6 weeks 15 16 96.6 85.8 19.9 21.9 98.4 94.6 26.0 27.76 weeks 10 16 117.0 102.3 34.0 32.4 116.9 113.8 29.8 36.26 weeks 15 16 92.9 135.8 42.9 41.4 99.4 145.2 35.0 41.337.2 - - - - -36 - - - - -nd - - - - -nd - - - - -nd - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -10 year - - - - -- 19 61.2 - - -- 14 66.1 - - -- 18 60.8 - - -- 19 21.9 - - -- 14 23.4 - - -- 18 21.9 - - -- 58 14 - 17 -- 55 14 - 38 -- 55 14 - 16 -- 12 15 - 16 -- 14 14 - 28 -- 8 13 - 11 -- 58 152 - 2.7% -- 55 152 - 2.8% -- 55 154 - Delta =2.0% -- 12 141 - 5.0% -

- 14 140 - 5.6% -- 8 142 - Delta=3.8% -- 58 47 - 8.8% -- 55 47 - 9.7% -- 55 48 - Delta =8.6% -- 12 35 - 15.3% -- 14 36 - 18.4% -- 8 37 - Delta=14.9% -- 58 1.1 - 6.1% -- 55 1.1 - 6.2% -- 55 1.2 - Delta = 5.0% -- 12 0.7 - 11.4% -- 14 0.8 - 11.6% -- 8 0.8 - Delta = 7.4% -- 58 78 - 78 -- 55 83 - 105 -- 55 86 - 76 -- 17 nd nd - 1695- 13 nd nd - 1064- 12 nd nd - 2000- 15 nd nd - 927- 13 nd nd - 862- 13 nd nd - 763- 15 nd nd - 873- 20 nd nd - 706- 20 nd nd - 1005- 21 nd nd - 958- 19 nd nd - 585- 23 nd nd - 671- 15 nd nd - 3.6- 13 nd nd - 1.7- 12 nd nd - 2.4- 18 nd nd - 3.0- 15 nd nd - 1.9- 16 nd nd - 3.5- 15 nd nd - 1.7- 20 nd nd - 2.1- 20 nd nd - 1.8- 22 nd nd - 1.8- 10 nd nd - 3.4- 23 nd nd - 3.7- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1 81 59.84 11.33 59.94 11.37nd 77 59.65 15.34 59.25 14.801 81 140.34 20.55 137.65 22.14nd 77 131.71 23.91 134.46 21.311 81 81.17 9.87 73.39 10.67nd 77 79.09 9.89 73.50 10.425 years - - - - -5 years - - - - -5 years - - - - -5 years - - - - -5 years - - - - -5 years - - - - -nd 3 42.4 13 -9.2 153 wk 6 32.4 10.7 30.4 9.5nd 4 39.9 6.1 -3.7 6.33 wk 5 39.9 9.3 7.5 13nd 3 7.5 13 -7.5 133 wk 6 0 0 37 9.4nd 4 5.0 10.0 0.0 0.03 wk 5 0 0 19.5 12.8nd 3 34.9 0.0 -1.7 6.33 wk 6 32.4 10.7 -6.7 6.8nd 4 34.9 6.1 -3.7 6.33 wk 5 39.9 9.3 -12.0 5.7- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -12 mo. 23 82.7 SD = 10.0 Delta = -10.8 SD = 5.912 mo. 21 80.9 SD = 8.7 Delta = -9.6 SD = 6.5nd 25 nd nd 104.1 9.62 y 37 nd nd 101.9 12.9nd 25 nd nd 67.8 8.22 y 37 nd nd 67.1 7.730 83 71.5 SD = 1.24 Final = 72.8 Final SD = 1.3- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- 21 85.37 - - -- 25 84.95 - - -- 21 83.43 - - -- 21 32.36 - - -- 25 32.39 - - -- 21 32.42 - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -24 mo 27 17 2.0 19 2.8nd 32 17 3.0 19 3.324 mo 27 32.2 4.6 42.9 7.5nd 32 33.2 6.7 44.1 9.924 mo 27 137 6.3 151 7.0nd 32 138 4.6 151 6.0- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- nd 72.1 - 71.1 -- nd 71.6 - 71 -- nd 71.8 - 96.0 -2 - - - - -2 - - - - -2 - - - - -2 - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -4 16 ~24 ~4 ~20 ~2nd 16 ~29 ~3 ~21 ~24 16 ~30 ~3 ~21 ~3nd 16 ~31 ~2 ~31 ~24 16 ~124 (figure) ~2 (figure) -7.8 -16, +4nd 16 ~122 ~2 -2.1 -15, +74 16 ~78 ~2 -2.6 -14, +6nd 16 ~76 ~2 +0.9 -4, +164 16 114 2 ~110 ~2nd 16 114 2 ~112 ~24 16 74 2 ~73 ~1nd 16 72 2 ~72 ~1- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1 y 30 51.8 1.7 56.9 1.81 y 30 50.7 1.6 55.6 1.61 y 24 52.2 1.7 56.3 1.81 y 26 49.5 1.7 52.5 1.61 y 30 162.5 1.1 166.2 1.01 y 30 161.9 1.2 165.9 1.11 y 24 159.6 1.3 163.2 1.31 y 26 160.1 1.5 163.2 1.41 y 29 37.5 2 35.1 31 y 29 39.2 3 32.2 21 y 24 30.8 2 25.7 31 y 24 29.2 2 28.5 3

- - - - -367 days (IQR: 139 618) in the

- - - - -3 yr - - - - -3 yr - - - - -nd 33 83.6 11.1 80.6 11.715 wk 30 81.5 8.3 77.5 9.0nd 33 32.3 3.54 31.1 3.715 wk 30 31.4 2.5 29.8 2.8nd 33 109.5 8.5 -1.6 7.615 wk 30 112.4 10.8 -4.1 6.8nd 33 75.2 7.0 -3.0 5.915 wk 30 74.9 8.9 -3.0 4.9- 29 nd nd - -- 21 nd nd - -- 27 nd nd - -- 29 nd nd - -- 21 nd nd - -- 27 nd nd - -- 29 nd nd - -- 21 nd nd - -- 27 nd nd - -- 29 nd nd - -- 21 nd nd - -- 27 nd nd - -- nd nd nd - -- nd nd nd - -- nd nd nd - -74 mo - - - - -74 mo - - - - -74 mo nd nd nd nd nd74 mo nd nd nd nd nd74 mo nd nd nd nd nd74 mo nd nd nd nd nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -pregnancy - - - - -pregnancy - - - - -

median time to first fracture =

nd 100 nd nd 2.99 0.36nd 100 nd nd 2.80 0.37nd 100 nd nd 50.06 1.79nd 100 nd nd 48.45 2.04nd 100 nd nd 38.65 1.77nd 100 nd nd 38.86 1.69- 13 - - - -- 13 - - - -- 12 - - - -- 13 - - - -- 13 - - - -- 12 - - - -nd 59 nd nd 63.3 20.7nd 67 nd nd 46.4 29.5nd 59 nd nd 3157 469nd 67 nd nd 3034 524- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- 27 nd nd - -- 347 nd nd - -- 27 nd nd - -- 347 nd nd - -- - - - - -- - - - - -- 36 1.12 - - -- 26 1.077 - - -- 39 1.133 - - -

1.5 35 124 11 0.60 9.821.5 36 124 10 -3.35 7.211.5 32 124 11 0.60 9.821.5 33 124 10 -3.09 7.141.5 35 78 8 0.43 7.661.5 36 77 9 -1.26 5.971.5 32 78 8 0.43 7.661.5 33 77 9 -1.11 5.991.5 35 36.5 14.55 35.1 27.281.5 36 30.0 12.50 0.60 11.611.5 32 36.5 14.55 35.1 27.281.5 33 30.0 12.50 0.65 11.781.5 35 nd nd +0.03 1.821.5 36 nd nd -0.38 1.701.5 32 nd nd +0.35 1.601.5 33 nd nd -0.41 1.731.5 35 26.7 4.54 -0.02 0.621.5 36 26.0 3.46 -0.04 0.681.5 32 26.7 4.54 +0.08 0.561.5 33 26.0 3.46 -0.05 0.6912 mo 55 62.1 24.0 35.3 23.212 mo 31 61.9 22.6 10.9 16.9- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -8 wks 72 140.6 14.7 134.9 19.98 wks 73 144.1 20.4 131.0 16.98 wks 72 82.6 6.4 75.7 12.58 wks 73 84.7 7.6 77.5 12.48 wks 72 24.63 12.14 44.36 27.388 wks 73 25.65 13.63 64.84 25.84- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -nd 739 67.1 11.8 -0.369 0.13430 732 66.9 11.5 -0.368 0.132nd 739 26.4 4.2 +0.02 0.0530 732 26.5 4.3 +0.01 0.05nd 739 133.9 22.9 +2.4 0.930 732 134.9 22.6 0.0 0.930 732 70.1 10.7 -0.2 0.4- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -5 wks 94 147 23 -5 165 wks 95 149 22 -5 135 wks 94 82 10 -1 9

5 wks 95 82 12 -1 95 wks 94 12.9 5.4 -1.4 1.15 wks 95 13.8 5.9 +7.2 3.8- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- 116 101 - - -- 112 100.6 - - -- 116 35.0 - - -- 112 35.1 - - -- 116 54.5 - - -- 112 53.2 - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1 yr 14 60.6 SD = 5.4 61.0 SD = 5.11 yr 14 66.4 SD = 13.8 67.0 SD = 14.060-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -

nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -60-69 - - - - -nd - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -6 weeks 29 61.8 SD = 6.9 Final = 61.5 Final SD = 6.46 weeks 29 62.5 SD = 6.9 Final = 63.0 Final SD = 6.66 weeks 29 20.8 SD = 2.0 Final = 20.7 Final SD = 1.96 weeks 29 21.0 SD = 1.9 Final = 21.1 Final SD = 1.8- - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -

84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -84 - - - - -nd 10 nd nd 32.2 ndnd 9 nd nd 34 ndnd 10 nd nd 35.1 ndnd 9 nd nd 47.1 ndnd 10 nd nd 33 ndnd 9 nd nd 36 ndnd 10 nd nd 35.1 ndnd 9 nd nd 48.4 ndnd 10 nd nd 28.9 ndnd 9 nd nd 45 ndnd 10 nd nd 6.7 0.5nd 9 nd nd 6.6 0.8nd 10 nd nd 25.9 ndnd 9 nd nd 50.6 ndnd 10 nd nd 33.5 ndnd 9 nd nd 51.9 ndnd 10 nd nd 38.4 ndnd 9 nd nd 58.8 ndnd 10 nd nd 43 ndnd 9 nd nd 46 ndnd 10 nd nd 2.2 ndnd 9 nd nd 4.1 ndnd 10 nd nd 59.6 ndnd 9 nd nd 82.4 ndnd 10 nd nd 13 ndnd 9 nd nd 14 ndnd 10 nd nd 4.7 0.4nd 9 nd nd 4.6 0.7nd 10 nd nd 54.6 1.1nd 9 nd nd 55.9 2.9- - - - - -- - - - - -- - - - - -5.4 yr - - - - -nd - - - - -9 15 13.5 1.5 11.4 1.215 13.7 0.9 10.7 1.1 nd9 15 28.2 2.8 23.1 2.415 27.3 2.6 21.5 1.8 nd9 15 0.6 0.2 0.5 0.2

15 0.7 0.4 0.7 0.3 nd9 15 nd nd nd nd15 nd nd nd nd nd6 15 1021 170 2828 31615 914 141 723 78 -1926 15 130 28 337 15815 114 23 100 16 -406 15 100 24 109 1215 68 9 74 11 +5- - - - - -- - - - - -- - - - - -18 mo 221 126.0 7.7 nd ndnd 224 125.4 8.8 nd nd18 mo 221 84.1 2.9 nd ndnd 224 83.9 2.8 nd nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- nd nd nd - ndnd nd nd - ndnd nd nd - ndnd nd nd - ndnd nd nd - ndnd nd nd - ndnd nd nd - ndnd nd nd - nd6 mo. 217 27.4 3.7 +0.07 0.956 mo. 218 27.0 3.7 +0.12 1.02108 - - - - -108 - - - - -108 - - - - -- 37 66.6 - - -- 34 70.2 - - -- 38 67.3 - - -36 35 66.6 25.9 74.6 23.836 32 70.2 25.6 118.4 44.3836 32 67.3 34.2 63.6 32.360 34 66.6 25.9 63.7 28.760 29 70.2 25.6 106.4 29.060 30 67.3 34.2 61.5 23.012 40 / 38 833.9 92.9 -0.17 nd12 41 /36 827.8 125.4 1.27 -12 39 / 33 782.9 88.8 0.19 nd- 39 / 33 782.9 - - -- 41 / 36 827.8 - - -12 133 826 129 0.2% 0.212 123 851 127 0.5% 0.312 133 43.7 12.9 0% nd12 123 44.8 12.7 34% nd

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

2734 p-yr (~1337) - - -39 (14.3/1000 p-y 2726 p-yr (~1337) - - -35 (12.9/1000 p-y 2706 p-yr (~1337) - - -30 (11.2/1000 p-y 2668 p-yr (~1337) - - -37 (13.7/1000 p-y 2692 p-yr (~1337) - - -

- - - Crude 5.2, 17.1 29.3- - - Crude 12, 21.1 47.0- - - Crude 5.3, 23.6 5.75- - - Crude 6.9, 14.3 40.9- - - Crude 8.3, 17.5 46.2- - - Crude 7.5, 19.4 10.1- - - Crude 12.6, 28.2 39.4

Mean Ca level / dose

No. of Cases

Person Years (N)

Crude or Adjusted

Baseline IQR

Final (median)

nd (mean 0.9 0.2)

39 (14.3/1000 p-yr)nd (mean 1.0

0.2)nd (mean 1.2 0.2)nd (mean 1.4 0.3)nd (mean 1.7 0.4)

- - - Crude 13.6, 29.2 54.7- - - Crude 15, 25.2 19.1- - - Crude 0.99, 1.06 1.06- - - Crude 0.93, 1.05 0.99- - - Crude 0.91, 1.12 1.00- - - Crude 0.94, 1.07 1.05- - - Crude 0.89, 1.08 1.00- - - Crude 0.96, 1.14 1.06- - - nd 1104, 1726 1595- - - nd 1209, 1887 1625- - - crude 1399, 1767 1923- - - Crude 1104, 1726 1595- - - Crude 1209, 1887 1625- - - Crude 1399, 1767 1923- 85 - - - -- 297 - - - -- 333 - - - -- 195 - - - -- 338 - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- 87 5,581 Adjusted - -- 608 36,605 Adjusted - -- 712 42,544 Adjusted - -- 407 24,240 Adjusted - -- 712 41,325 Adjusted - -- - - 8 y - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - nd - -- - - nd - -- - - Crude - -- - - nd - -- - - Crude - -- - - - - -- - - - - -- - - adj - -- - - adj - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 8 y - -- - - nd - -- - - nd - -- - - nd - -- 7 - - - -- 17 - - - -- 16 - - - -- 4 - - - -- 17 - - - -- 54 - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 9 - -- - - 9 - -- - - 9 - -- - - 9 - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 132 - -- - - 132 - -- - - 132 - -- - - 132 - -- - - 7 y - -- - - 7 y - -- - - 7 y - -- - - 7 y - -- - - 7 y - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adj - -- - - nd - -- - - nd - -- - - nd - -- - - adj - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- 1704 - - - -nd nd - - - -nd nd - - - -nd nd - - - -nd nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- - - - - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjsuted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -

- - - Adjusted - -- - - Adjusted - -- - - Ajusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- 53 - - - -- 47 - - - -- 35 - - - -- 29 - - - -- 29 - - - -- 34 - - - -- 42 - - - -

- 33 - - - -- 38 - - - -- 46 - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- 151 - - - -- 195 - - - -- 188 - - - -- 208 - - - -- 520 - - - -- 222 - - - -nd 175 - - - -nd 103 - - - -nd 117 - - - -nd 80 - - - -nd 41 - - - -nd 20 - - - -nd 57 - - - -nd 51 - - - -nd 23 - - - -nd 22 - - - -nd 34 - - - -nd 37 - - - -nd 20 - - - -nd 8 - - - -

Age and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy onlyAge and energy only

nd 22 - - - -nd 25 - - - -nd 16 - - - -nd 24 - - - -nd 28 - - - -nd 24 - - - -nd 14 - - - -nd 38 - - - -nd 60 - - - -nd 32 - - - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - crude - -- - - nd - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -

- - - Adjusted for age - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -

- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - Adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - Adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - Adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - 85.2 - -- - - 85.2 - -- - - 85.2 - -- - - 85.2 - -- - - - -- - - nd - -- - - nd - -- - - nd - -

Adjusted (age, gender, energy)

Adjusted (age, energy intake)

- - - nd - -- - - Median, 82.8 - -- - - Median, 82.8 - -- - - Median, 82.8 - -- - - Median, 82.8 - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - Yes - -- - - adj - -- - - adj - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adj (age) - -- - - nd - -- - - nd - -- - - nd - -- - - Adj (age) - -- - - nd - -- - - nd - -- - - nd - -- - - Adj (age) - -- - - nd - -

- - - nd - -- - - nd - -- - - Adj (age) - -- - - nd - -- - - nd - -- - - nd - -- - - Adj (age) - -- - - nd - -- - - nd - -- - - nd - -- - - Adj (age) - -- - - nd - -- - - nd - -- - - nd - -- - - 13.6 years - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - 9.4 yrs - -- - - 9.4 yrs - -- - - 9.4 yrs - -- - - 9.4 yrs - -- - - 9.4 yrs - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -

- - - adjusted - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 10 y (120 mo) - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Age, randomized treatment, BMI,

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - crude - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - crude - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adjusted - -- - - nd - -- - - nd - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - nd - -- - - nd - -- - - Adjusted - -- - - nd - -- - - 36.8 - -- - - 36.8 - -- - - 36.8 - -- - - 36.8 - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - crude 31.2-61.2 47.5- - - nd 23.7-45 67.5- - - nd 27.5-37.5 97.7- - - crude 31.2-61.2 55- - - nd 23.7-45 77.5- - - nd 27.5-37.5 97.7- - - - - -- - - - - -- - - - - -- - - - - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - ~32 y - -- - - ~32 y - -- - - ~32 y - -- - - ~32 y - -- - - ~32 y - -- - - ~39 - -- - - ~39 - -- - - ~39 - -- - - ~39 - -- - - ~39 - -0-199 mg/d - - - - -200-449 - - - - -450-599 - - - - -600 - - - - -0-199 mg/d - - - - -200-449 - - - - -450-599 - - - - -600 - - - - -- - - adj - -- - - nd - -- - - nd - -- - - nd - -- - - adj - -- - - adj - -- - - Crude - -- - - Crude - -- - - Crude - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -

crude (conditional logistic)crude (conditional logistic)

- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - 87.6 - -- - - adj - -- - - adj - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 96 - -- - - 96 - -- - - 96 - -- - - 96 - -- 97 - - - -

- 71 - - - -- 84 - - - -- 74 - - - -- 103 - - - -- 62 - - - -- 61 - - - -- 100 - - - -- 16 - - - -- 18 - - - -- 13 - - - -- 18 - - - -- 24 - - - -- 7 - - - -- 10 - - - -- 24 - - - -- 81 - - - -- 53 - - - -- 71 - - - -- 56 - - - -- 79 - - - -- 55 - - - -- 51 - - - -- 76 - - - -- 45 - - - -- 24 - - - -- 26 - - - -- 47 - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - adj - -- - - nd - -- - - nd - -- - - Adjusted - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -

147,858 person-years137,184 person-years88,023 person-years23,174 person-years8,152 person-years

- - - - - -- - - - - -- - - - - -- - - Median, 68.9 - -- - - Median, 68.9 - -- - - Median, 68.9 - -- - - Median, 68.9 - -- - - Median, 68.9 - -- - - - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - crude - -- - - crude - -- - - crude - -- - - crude - -- - - crude - -- - - crude - -- - - - - -- - - - - -- - - - - -

Adjusted (but no dietary vitamin D)

- - - - - -- - - - - -- - - - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Age and multivariable

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 13 y - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

adjusted for sex, age, education

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 127 - -- - - 127 - -- - - 127 - -- - - - - -- - - - - -- - - - - -- - - - - -- - - nd - -- - - nd - -- - - nd - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -- - - Adjusted - -

- - - Adjusted - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - nd - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Crude - -- - - Crude - -- - - Crude - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Final (IQR) Total N** Ca intake- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -28.5, 64.0 - - - - -28.7, 61.5 - - - - -4.68, 16.0 - - - - -37.4, 47.7 - - - - -38.6, 53.2 - - - - -8.38, 16.1 - - - - -31, 48.2 - - - - -

Outcome Metric (e.g.

Mean Follow up

Outcome effect size

45.2, 65.1 - - - - -13.1, 22.6 - - - - -1.01, 1.11 - - - - -0.93, 1.06 - - - - -0.89, 1.16 - - - - -0.97, 1.11 - - - - -0.88, 1.12 - - - - -0.90, 1.14 - - - - -1302, 1953 - - - - -1380, 21440 - - - - -1730, 2145 - - - - -1302, 1953 - - - - -1380, 21440 - - - - -1730, 2145 - - - - -- 1677 - - - -- 7504 - - - -- 8576 - - - -- 5038 - - - -- 7890 - - - -- 14354 - - - -- 14354 - - - -- 14354 - - - -- 16314 - - - -- 16314 - - - -- 16314 - - - -- - <400 RR 14 y -- - 400-599 RR 14 y -- - 600-799 RR 14 y -- - 800-1000 RR 14 y -- - 1000 RR 14 y -- - - - RR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Adjusted multivariate

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - nd - nd- - - nd - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adjusted - RR- - - nd - nd- - - nd - nd- - - nd - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - crude - %- - - crude - %- - - crude - %- - - crude - %- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adjusted - RR- - - Adjusted - RR- - - Adjusted - RR- - - Adjusted - RR- - - Adj - OR- - - Adj - OR- - - Adj - OR- - - Adj - OR- - - Adj - OR- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- - - - -- - - - 18 months -- - - - 18 months -- - - - 18 months -- - - - 18 months -- - - - 18 months -- - - - 18 months -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

OR (incrase in Ca intake)

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - RR (HR) - 1.00- - - RR (HR) - 1.03- - - RR (HR) - 0.80- - - RR (HR) - 0.96- - - RR (HR) - 0.74- - - RR (HR) - 1.00- - - RR (HR) - 1.19- - - RR (HR) - 1.10- - - RR (HR) - 1.23- - - RR (HR) - 0.93- - - RR (HR) - 0.68- - - RR (HR) - 0.83- - - RR (HR) - 0.54- - - RR (HR) - 0.89- - - RR (HR) - 1.0- - - RR (HR) - 0.71- - - RR (HR) - 0.71- - - RR (HR) - 0.86- - - RR (HR) - 0.76- - - RR (HR) - 1.0- - - RR (HR) - 1.00- - - RR (HR) - 0.84- - - RR (HR) - 0.66- - - RR (HR) - 0.78- - - RR (HR) - 0.69- 369 - - - -- 374 - - - -- 370 - - - -- 371 - - - -- 975 - - - -- 509 - - - -- 5744 - - - -- 3141 - - - -- 3713 - - - -- 4218 - - - -- 4218 - - - -- 4218 - - - -- 5744 - - - -- 6856 - - - -- 4218 - - - -- 4218 - - - -- Nd - - - -- Nd - - - -- Nd - - - -- Nd - - - -

- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- nd - - - -- - - RR - 1.0- - - RR - 1.02- - - RR - 1.36- - - RR - 1.13- - - RR - 1.04- - - RR - 1.0- - - RR - 1.22- - - RR - 1.28- - - RR - 1.47- - - RR - 1.23- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - OR - 1.0- - - nd - 1.11- - - nd - 1.75- - - nd - 1.62- - - OR - 1.00- - - nd - 1.10- - - nd - 1.16- - - nd - 0.92- - - OR - 1.00- - - nd - 1.13- - - nd - 0.85- - - nd - 0.88

- - - HR - nd- - - HR - nd- - - HR - nd- - - HR - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - OR - 1.0- - - OR - 1.12- - - OR - 1.02- - - OR - 1.00- - - OR - 0.86- - - OR - 1.0- - - OR - 1.19- - - OR - 1.00- - - OR - 1.56- - - OR - 0.93- - - OR - 1.0

- - - OR - 1.33- - - OR - 1.29- - - OR - 1.30- - - OR - 0.88- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - OR - 1.00- - - nd - 1.71- - - nd - 0.75- - - OR - 1.00- - - nd - 1.44- - - nd - 1.06- - - RR (HR) - 1.00- - - nd - 1.17- - - nd - 1.37- - - nd - 1.43- - - RR (HR) - 1.00- - - nd - 1.44- - - nd - 1.04- - - nd - 0.63- - - RR (HR) - 1.00- - - nd - 0.77- - - nd - 1.88- - - nd - 3.01- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - RR - 1.00- - - RR - 0.83- - - RR - 0.96- - - RR - 0.92- - - RR - 0.92- - - adjusted - HR- - - nd - nd- - - nd - nd- - - nd - nd- - - OR - 1.0- - - nd - 0.57- - - nd - 0.60- - - nd - 0.61

- - - nd - 0.58- - - Adjusted - RR- - - Adjusted - RR- - - Adjusted - RR- - - Adjusted - RR- - - RR - 1- - - RR - 0.73- - - RR - 0.65- - - RR - 0.50- - - RR - 1- - - RR - 0.71- - - RR - 0.67- - - RR - 0.76- - - RR - 1- - - RR - 0.77- - - RR - 0.63- - - RR - 0.26- - - RR - 1.00 (ref)- - - RR - 1.00 (ref)- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - % - 6.9%- - - nd - 3.8%- - - nd - 2.9%- - - nd - 6.8%- - - nd - 3.6%- - - nd - 2.0%- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - RR (HR) - 1.0- - - nd - 0.81- - - nd - 0.77- - - nd - 0.73- - - RR (HR) - 1.0- - - nd - 0.91- - - nd - 0.67- - - nd - 0.69- - - RR (HR) - 1.0- - - nd - 0.74

- - - nd - 0.84- - - nd - 0.78- - - RR (HR) - 1.0- - - nd - 0.81- - - nd - 0.77- - - nd - 0.73- - - RR (HR) - 1.0- - - nd - 0.91- - - nd - 0.67- - - nd - 0.69- - - RR (HR) - 1.0- - - nd - 0.74- - - nd - 0.84- - - nd - 0.78- - - - RR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - Adjusted - RR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - OR - 1.01- - - nd - 1.26- - - nd - 1.00- - - nd - Reference- - - OR - 0.91- - - nd - Reference- - - OR - 1.33- - - nd - 1.16- - - nd - nd- - - nd - Reference- - - OR - 1.27- - - nd - 1.33- - - nd - 0.97- - - nd - Reference- - - OR - 1.37- - - nd - Reference- - - OR - 2.06- - - nd - 1.08- - - nd - 1.24- - - nd - Reference- - - OR - 1.03- - - nd - 1.32- - - nd - 1.02- - - nd - Reference

Adjusted ( multivariate )

- - - OR - 1.19- - - nd - Reference- - - OR - 1.34- - - nd - 1.41- - - nd - 0.91- - - nd - Reference- - - OR - 1.93- - - nd - Reference- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - Adj (first model) - RR (HR)- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - HR - 1 (Ref)- - - HR - 0.78- - - HR - 0.60- - - HR - 0.78- - - HR - 0.64- - - HR - 1.0 (Ref)- - - HR - 1.12- - - HR - 1.10- - - HR - 1.10- - - HR - 1.23- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - RR - 1- - - nd - 0.866- - - nd - 1.14- - - RR - 1- - - RR - 1- - - RR - 1- - - nd - 0.981- - - nd - 1.34- - - RR - 1- - - nd - nd- - - adjusted - OR- - - adjusted - OR- - - adjusted - OR- - - adjusted - OR- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -38.7-66.2 - - - - -57.5-91.2 - - - - -79.1-111.8 - - - - -72.5-68 - - - - -66.2-156.2 - - - - -79.3-123.1 - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- - - Adj - coefficient- 10011 - - - -- 10011 - - - -- 10011 - - - -- 10011 - - - -- 10011 - - - -- 10011 - - - -- 10011 - - - -- 10011 - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - RR - 1.00 (ref)- - - RR - 1.00 (ref)- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - OR - 1.0 (Ref)- - - nd - 1.0 (Ref)- - - RR - 1- - - RR - 1.05- - - RR - 0.96- - - RR - 0.96- - - RR - 0.88- - - RR - 1- - - RR - 1.04- - - RR - 0.96- - - RR - 0.97- - - RR - 0.90- - - RR - 1- - - RR - 1.02- - - RR - 0.93- - - RR - 0.91- - - RR - 0.85- - - RR - 1.0 (ref)- - - RR - 0.76- - - RR - 0.76- - - RR - 0.73- - - RR - 1.0 (ref)- - - RR - 1.0- - - RR - 1.2- - - RR - 1.1- - - RR - 1.0 (ref)

- - - RR - 0.98- - - RR - 1.0- - - RR - 1.2- - - RR - 1.0 (ref)- - - RR - 1.7- - - RR - 2.1- - - RR - 2.1- - - RR - 1.0 (ref)- - - RR - 0.17- - - RR - 0.25- - - RR - 0.075- - - RR - 1.0 (ref)- - - RR - 0.26- - - RR - 0.46- - - RR - 0.33- - - Adjusted - RR- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - Adjusted - nd- - - RR - 1.01- - - RR - 0.76- - - RR - 1.00- - - nd - 1.03- - - nd - 1.04- - - nd - 1.05- - - nd - 1.04- - - RR - 1.00- - - nd - 1.15- - - nd - 1.06- - - nd - 1.11- - - nd - 1.09- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - RR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - HR - 1.00- - - nd - 0.98- - - nd - 0.99- - - RR - 1.0- - - nd - 0.8- - - nd - 1.0- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - RR - 1- - - OR - 1.5- - - OR - 1.1- - - OR - 1.1- - - OR - 0.6- - - OR - 1.0- - - OR - 3.1- - - OR - 1.6- - - OR - 3.8- - - OR - 1.8- - - OR - 1.0- - - OR - 1.1- - - OR - 1.1- - - OR - 0.8- - - OR - 0.9- - - OR - 1.0- - - OR - 1.0- - - OR - 1.0- - - OR - 1.0- - - OR - 0.8- - - OR - 1.0- - - OR - 1.2- - - OR - 1.1- - - OR - 1.3- - - OR - 1.1- - - OR - 1.0- - - OR - 1.1- - - OR - 0.8- - - OR - 1.6- - - OR - 1.4- - - OR - 1.0- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - OR - 1.00- - - OR - 1.30- - - OR - 2.12- - - OR - 1.50- - - OR - 2.92- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - HR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - - HR- - - nd - nd- - - nd - nd- - - nd - nd- - - nd - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - HR - 1.61- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Adjusted ( multivariable+

Adjusted ( multivariable+

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - HR - 1.80- - - HR - 1.53- - - nd - nd- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - HR- - - adjusted - HR- - - adjusted - HR- - - - - -- - - - - -- - - - - -- - - - - -- - - adjusted - RR- - - adjusted - RR- - - adjusted - RR- - - OR - 1.0 (ref)- - - nd - 0.97- - - nd - 0.66- - - nd - 0.51- - - nd - 0.83- - - OR - 1.0 (ref)- - - nd - 0.74- - - nd - 0.29- - - nd - 0.46- - - OR - 1.0 (ref)- - - nd - 0.84- - - nd - 0.35- - - nd - 0.69- - - OR - 1.0 (ref)- - - nd - 0.93- - - nd - 0.31- - - nd - 0.71- - - OR - 1.0 (ref)- - - nd - 1.74- - - nd - 3.32- - - OR - 1.0 (ref)- - - nd - 1.29- - - nd - 0.63- - - nd - 0.63- - - nd - 0.84- - - OR - 1.0 (ref)- - - nd - 0.91- - - nd - 0.32- - - nd - 0.43

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

CI P between Delta**- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Net difference

Net difference

Mean Follow up

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1.0 - - - - -0.95 - - - - -0.72 - - - - -0.84 - - - - -0.88 - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- -0.25 nd 0.34 - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - nd +26.5- - - - nd +49.1- - - - 6 +1.9nd - - - - -nd - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1.00 - - - - -0.62 - - - - -0.75 - - - - -0.67 - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -45 (estimate) - - - - -75 (estimate) - - - - -63 (estimate) - - - - -65 (estimate) - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1.00 - - - - -1.21 - - - - -1.35 - - - - -1.29 - - - - -0.89 - - - - -1.25 - - - - -1.07 - - - - -0.69 - - - - -0.91 - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - 24 mo 34.7%- - - - nd 35%- - - - nd 38.1%- - - - nd 35%- - - - 24 mo 9.8%- - - - nd 9.7%- - - - nd 10.4%- - - - nd 8.9%- - - - - -- - - - - -- - - - - -

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Mean Follow-up,

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No. of Total person-

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N Total Total N Final **- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -


Mean Follow-up

Baseline SD*

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RR ca+vitD / placeboRR ca+vitD / placeboOR ca+vitD / placeboOR ca+vitD / placebo

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HR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placebo

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HR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placeboHR Vit D+Ca / placebo

Unadjusted: Rate (age and sex Unadjusted: Rate (age and sex

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Mean Vit D level /

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Exposure Categories(

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Final Delta SD Delta **- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

Baseline (median)

No. of Event*

Baseline SE*

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Delta CI*- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

No. of Non-cases**

Mean Follow up,

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- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - --1.4, -0.1 % - --0.4, 1.6 % - -0.9, 2.2 % - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- 80 -

- 84 -- 80 -- 82 -- 82 -- 80 -- 82 -- 82 -- 17 -- 14 -- 16 -- 18 -- 18 -- 16 -- 13 -- 18 -- 63 -- 70 -- 64 -- 64 -- 64 -- 64 -- 69 -- 64 -- 36 -- 37 -- 35 -- 34 -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- -- -- -

Median 5.4 y (up to 11.7 y)Median 5.4 y (up to 11.7 y)Median 5.4 y (up to 11.7 y)

- -- -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

Median 5.4 y (up to 11.7 y)Median 5.4 y (up to 11.7 y)

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -- - -

Study ID:EF ID Creator Create Date PMIDLast Updated

Alt ID(s) Title Year Author

ArmAdverse Event

Adverse Event

Arm Description

No Advers


Last Updated

















6465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016465:194 admin Aug 18, 2013 Sep 5, 2014 176238016466:194 admin Aug 18, 2013 Sep 5, 2014 77958376466:194 admin Aug 18, 2013 Sep 5, 2014 77958376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376467:194 admin Aug 18, 2013 Sep 5, 2014 95214376468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016468:194 admin Aug 18, 2013 Sep 5, 2014 180897016469:194 admin Aug 18, 2013 Sep 5, 2014 184102256469:194 admin Aug 18, 2013 Sep 5, 2014 18410225


















































200820082008200820082008200820082008200819921992199219921992199219921992199619961996199619981998199819982005200520052005200520052005200520052005200520052005200520082008200820072008200820082008

Effect of vitamin D supplementation on bone

Andersen R., Mølgaard C., Skovgaard LT., Brot C., Effect of vitamin D
















































200720072008199319931993199319931993199319931999199919991995199519951995199520082008200820082008200820062006200620062006200620062006200620062007200720012001200120012008200820082008200820082008

Two-year randomized controlled trial of vitamin

Bolton-Smith C., McMurdo ME., Paterson CR., Mole Two-year randomized




































inpatients falling? A Burleigh E., McColl J., Potter J.Dairy products, calcium,












200420042004-- Not Found ---- Not Found --1996199619961996199619961996199619961996199619961996199619961996199619961996199619961996199619962006200620062006200620062006200620062006200620062006200620062006200620062006

Weight loss and calcium intake influence calcium

Cifuentes M., Riedt CS., Brolin RE., Field MP., Weight loss and calcium




























and incidence of treated Dwyer JH., Li L., Dwyer KM., Curtin LR., Feinleib M.Effect of vitamin D




















200620062006200620062006200620062006200620062006200420042004200420042004200420042004200420042004200520052005200520052005200520052005200520052005200520052005200520052005200520052005200520052005

Effect of vitamin D replacement on

El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., Effect of vitamin D











replacement on El-Hajj Fuleihan G., Nabulsi M., Tamim H., Maalouf J., Plasma vitamin D





































200520082008200820082008200820082007200720072007200720072007200720072007200720072007200720072007200820082008200820082008200820082008200820082008200820081996199619961996199619961996199619851985

Calcium from diet and supplements is associated

Flood A., Peters U., Chatterjee N., Lacey JV., Plasma 25-hydroxyvitamin

































metabolites and breast Freedman DM., Chang SC., Falk RT., Purdue MP., Maternal vitamin D status














calcium and risk of Garland C., Shekelle RB., Barrett-Connor E., Criqui

198519851989198919891989198919891989198919891989199519951995200720072007199919991999199919991999200520052005200520052005200520052005200520052005200520052005200520032003199720042004200420042004

Dietary vitamin D and calcium and risk of

Garland C., Shekelle RB., Barrett-Connor E., Criqui Dietary vitamin D and









































supplementation and Hatton DC., Harrison-Hohner J., Coste S., Reller Long-term vitamin D3

supplementation may Heikkinen AM., Tuppurainen MT., Plasma levels of 25-





hydroxyvitamin D, 1,25-Jacobs ET., Giuliano AR., Martínez ME., Hollis BW.,

200420012001200120012001200120012001200120012001200119941994199419941994199719971997199719961996199619961996200520052005200520072007200720072007200720072007200720072007200720062006200420042004

Plasma levels of 25-hydroxyvitamin D, 1,25-

Jacobs ET., Giuliano AR., Martínez ME., Hollis BW., Prospective study on milk












products, calcium and Järvinen R., Knekt P., Hakulinen T., Aromaa A.Fermented dairy products,
































and prostate cancer risk.Koh KA., Sesso HD., Paffenbarger RS., Lee IM.Girls on a high-calcium




200720072007200720072007200820082006200620062006200620062006200620062006200620062006200620062006200620062006200620062006200620062008200820082008200920092009200920092007200720072007200720072007

Vitamin D and calcium supplementation reduces

Lappe JM., Travers-Gustafson D., Davies KM., Vitamin D and calcium
















































20072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720071995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.1995 Lijnen P., Petrov V.20052005200520052005200720072007200720072007200720072007200720062006

A prospective study of plasma vitamin D

Li H., Stampfer MJ., Hollis JB., Mucci LA., Gaziano JM., A prospective study of

























pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Dietary calcium, blood pressure and cell Intakes of calcium and vitamin D and risk of


















200620062006200620072007200720072007200720082008200820052005200520052005200520052005200520052002200220022002198719881988198819811981200320032003200320032008200820082008200820082008200820082008

Calcium supplementation for 1 y does not reduce

Lorenzen JK., Mølgaard C., Michaelsen KF., Astrup A.Calcium supplementation









calcium + vitamin D Major GC., Alarie F., Doré J., Phouttama S., Tremblay Effect of calcium and





















supplementation during Marya RK., Rathee S., Dua V., Sangwan K.Vitamin D supplements







products, and risk of McCullough ML., Robertson AS., Rodriguez Dietary calcium and










vitamin D intakes in Mishra G., McCormack V., Kuh D., Hardy R., Stephen

200620062006200620062006200620062006200120012009200920092009200920092009200920092009200919981998200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007

Dairy products, calcium and prostate cancer risk.

Koh KA., Sesso HD., Paffenbarger RS., Lee IM.Dairy products, calcium








and prostate cancer risk.Koh KA., Sesso HD., Paffenbarger RS., Lee IM.Nutrient intake and

hypertensive disorders of Morris CD., Jacobson SL., Anand R., Ewell MG., Nutrient intake and

hypertensive disorders of Morris CD., Jacobson SL., Anand R., Ewell MG., A double-blind,












metabolite levels and the Nomura AM., Stemmermann GN., Lee J., Serum vitamin D
















intakes in relation to risk Oh K., Willett WC., Wu K., Fuchs CS., Giovannucci EL.Plasma vitamin D and risk










200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720072007200720012001200119991999199919992000200020002000

Plasma vitamin D and risk of colorectal cancer: the

Otani T., Iwasaki M., Sasazuki S., Inoue M., Plasma vitamin D and risk

























risk of incident and fatal Park Y., Mitrou PN., Kipnis V., Hollenbeck A., Calcium, dairy foods, and











dairy product intake and Park SY., Murphy SP., Wilkens LR., Stram DO., Effects of a short-term












200020002000200020002000200020002000200020002000200020002000200020002000200020002005200520052005200320032003200320032007200720071997199719971995199519952006200620062006200620061993199319931993

Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D

Platz EA., Hankinson SE., Hollis BW., Colditz GA., Plasma 1,25-dihydroxy-


































dietary and other Ross RK., Yuan JM., Henderson BE., Park J., Effect of winter oral



vitamin D3 Scragg R., Khaw KT., Murphy S.Dietary intake of calcium,











199319931993199319931993199319931993199319931993199319931993199319931993199319931993199319931993199319932009200920092009200920062006200620062006199719971997199719971997199719971997199719971997

Calcium intake and 28-year gastro-intestinal

Slob IC., Lambregts JL., Schuit AJ., Kok FJ.Calcium intake and 28-

























year gastro-intestinal Slob IC., Lambregts JL., Schuit AJ., Kok FJ.Serum vitamin D and risk























199719971997199719971997199719971997199719872003200320032003200320032003200320032003200320032003200320032008200820082008200820082008200819861986200620062006200620062006200620062006200620062006

Serum levels of vitamin D metabolites and the

Tangrea J., Helzlsouer K., Pietinen P., Taylor P., Hollis Serum levels of vitamin D









metabolites and the Tangrea J., Helzlsouer K., Pietinen P., Taylor P., Hollis Dietary calcium intake and
















vitamin D3 Trivedi DP., Doll R., Khaw KT.Dietary calcium intake and










pressure: a controlled van Beresteyn EC., Schaafsma G., de Waard Low serum concentrations













200620062006200620062006200620062006200620062006200620082008200820081996199619961996199619961996200820082008199719972002200220022007200720072007200720072007200720072007200720072007200720072007

High-dose vitamin D3 supplementation in a

Wagner CL., Hulsey TC., Fanning D., Ebeling M., High-dose vitamin D3




























nonpharmacologic Whelton PK., Kumanyika SK., Cook NR., Cutler JA., Calcium intake and risk of




















2007200720072007200720072007200720072007200720072007199519951998199820082008200820082008

A nested case control study of plasma 25-

Wu K., Feskanich D., Fuchs CS., Willett WC., Hollis A nested case control






















Outcome Units Subgroup TimepointCategorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical nd N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)Categorical 12 (years)

kg Continuous Change in kg/yr All Participants N/A (years)Categorical 2 (years)Categorical 2 (years)Categorical 2 (years)Categorical 2 (years)ContinuousContinuous GirlsContinuous GirlsContinuous WomenContinuous WomenContinuous Men

Outcome Type

Outcome DescriptionProstate cancer

[nd:Categorical]All Participants [All participants Prostate cancer







[nd:Categorical]All Participants [All participants Aggressive


All Participants [All participants Aggressive














All Participants [All participants Prostate cancer

[nd:Categorical]All Participants [All articipants Prostate cancer





[nd:Categorical]All Participants [All articipants Prostate cancer in

those <52 years All Participants [All articipants Prostate cancer in

those >51 years All Participants [All articipants IHD (fatal +


All Participants [All articipants IHD (fatal +






All Participants [All articipants Nonfatal MI [Self-








All Participants [All articipants Fatal IHD








All Participants [All articipants Body weight

[Change in HTN, incident [Physician

Physician diagnosis (self-

All Participants [All articipants HTN, incident






All Participants [All articipants 25(OH)D

[Continuous]All Participants [All articipants

Enter a numeric value or title 25(OH)D

[Continuous]Enter a numeric value or title 25(OH)D




[Continuous]Enter a numeric value or title

Continuous MenContinuousContinuous WomenContinuous WomenContinuous MenContinuous MenContinuousContinuousContinuous GirlsContinuous GirlsCategorical 1Categorical 1Categorical 1Categorical 1Categorical 1 Age<=50Categorical 1 Age<=50Categorical 1 Age >50Categorical 1 Age >50CategoricalCategoricalCategoricalCategoricalCategorical not extracted Stroke N/A (years)Categorical not extracted Stroke N/A (years)Categorical not extracted Stroke N/A (years)Categorical not extracted Stroke N/A (years)Categorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical SecondaryCategorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Continuous All cause All Participants N/A (years)Continuous All cause All Participants N/A (years)

nmol/L Continuous All Participants N/A (years)Categorical 30 (weeks)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)

25(OH)D [Continuous]

Enter a numeric value or title BMD - lumbar

spine [DXA, whole DXA, whole body, or lumbar spine

All Participants [All articipants









Enter a numeric value or title BMC - whole body

[DXA, whole body, DXA, whole body, or lumbar spine









Enter a numeric value or title Incident HTN

[1 :Categorical]All Participants [All articipants








[1 :Categorical]Enter a numeric value or title Incident HTN



[1 :Categorical]Enter a numeric value or title Hypertension

[Categorical]All Participants [All articipants

Enter a numeric value or title Hypertension






Enter a numeric value or title specific stroke

types [not specific stroke types [not specific stroke types [not specific stroke types [not Prostate cancer risk


Enter a numeric value or title Prostate cancer

risk All Participants [All articipants









Enter a numeric value or title Breast cancer risk

[Risk of Risk of developing or newly Breast cancer risk







[Risk of Risk of developing or newly Mortality [All

cause:Continuous]Mortality [All cause:Continuous]25(OH)D at 1 y [Continuous]preeclampsia [gestational HTN

gestational HTN & proteinuria and

All Participants [All articipants Sudden death

[Standard criteria Standard criteria adjudicated by MI [Standard

criteria Standard criteria adjudicated by Stroke [Standard

criteria Standard criteria adjudicated by CVD Composite

(MI, Stroke, composite Adjudicated

mg/cm2 Continuous All Participants N/A (years)ug/L Continuous All Participants N/A (years)kg Continuous All Participants N/A (years)

Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous N/A (years)Kg Continuous N/A (years)Counts Continuous N/A (years)Counts Continuous N/A (years)seconds Continuous N/A (years)seconds Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)


m Continuous N/A (years)m Continuous Timed up and go N/A (years)

Categorical Fall N/A (years)Categorical Fracture N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Femoral neck BMD [DEXA of the

DEXA of the femur was carried out 25(OH)D

[Measured at Measured at baseline and Weight

[Continuous]Colon cancer [State Health

State Health registry of Colon cancer

[State Health State Health registry of Colon cancer






[State Health State Health registry of IHD death

[Categorical]IHD death [Categorical]IHD death [Categorical]Prostate cancer [25(OH)D]

Diagnosed 1980-1992, 6-18 y after

All Participants [All Participants]Prostate cancer








All Participants [All Participants]Grip strength [Two


Grip strength (year 2)Grip strength [Two


Grip strength (year 5)Chair stands


Chair stands (year 2)Chair stands


Chair stands (year 5)Timed walk [The


Timed walk (year 2)Timed walk [The


Timed walk (year 5)Muscle strength


Right quadriceps strength basalMuscle strength


Left quadriceps strength basalMuscle strength


Right hand grip strengthMuscle strength


Left hand grip strengthFall [Fall free


Fall free survival curveFall [Fall free






Fall free survival curveTwelve minutes

walk [Continuous]Twelve minutes walkTimed up and go

[Continuous]Fall [Defined as the patient

Defined as the patient fracture [Any

fracture incurred Any fracture incurred during Prostate cancer

[Requested Requested permission to Prostate cancer



[Requested Requested permission to Incident invasive


Invasive breast cancerIncident invasive










Total breast cancerIncident invasive


Death from breast cancer

Kg Continuous Body weight N/A (years)pmol/L Continuous 25(OH)D N/A (years)pmol/L Continuous 1,25(OH)D N/A (years)

Categorical N/A (years)Categorical Survival N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical HTN (Rx), Male N/A (years)Categorical HTN (Rx), Male N/A (years)Categorical HTN (Rx), Male N/A (years)Categorical HTN (Rx), Female N/A (years)Categorical HTN (Rx), Female N/A (years)Categorical HTN (Rx), Female N/A (years)Categorical HTN (Rx), Black N/A (years)Categorical HTN (Rx), Black N/A (years)Categorical HTN (Rx), Black N/A (years)Categorical HTN (Rx), White N/A (years)Categorical HTN (Rx), White N/A (years)Categorical HTN (Rx), White N/A (years)Categorical N/A (years)

ng/ml Continuous All Participants N/A (years)ng/ml Continuous All Participants N/A (years)ng/ml Continuous All Participants N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)ng/ml Continuous N/A (years)cm Continuous All Participants N/A (years)cm Continuous All Participants N/A (years)cm Continuous All Participants N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)cm Continuous N/A (years)kg Continuous All Participants N/A (years)kg Continuous All Participants N/A (years)kg Continuous All Participants N/A (years)kg Continuous N/A (years)kg Continuous N/A (years)

Weight change [Change in weight

Change in weight in kg25(OH)D

[Continuous]25(OH)D [Continuous]Adenomas recurrence [nd

nd (only for patients with

Adenomas recurrenceSurvival [nd (only

for patients with nd (only for patients with CRC HTN (Rx) [HTN


All Participants [All Participants]HTN (Rx) [HTN










HTN (Rx), Age 40 yHTN (Rx) [HTN






HTN (Rx), Age >40 yHTN (Rx) [HTN





medication HTN medication prescribedHTN (Rx) [HTN











medication HTN medication prescribedHTN (BP or Rx)

[SBP 160 or DBP SBP 160 or DBP 95 or medication

All Participants [All Participants]25(OH)D

[Continuous]25(OH)D [Continuous]25(OH)D [Continuous]25(OH)D [Continuous]

Premenarcheal girls (mean age = 25(OH)D

[Continuous]Premenarcheal girls (mean age = 25(OH)D

[Continuous]Premenarcheal girls (mean age = 25(OH)D

[Continuous]Premenarcheal girls (mean age = height

[Continuous]height [Continuous]height [Continuous]height [Continuous]

Premenarcheal girls (mean age = height



[Continuous]Premenarcheal girls (mean age = Weight

[Continuous]Weight [Continuous]Weight [Continuous]Weight [Continuous]

Premenarcheal girls (mean age = Weight

[Continuous]Premenarcheal girls (mean age =

kg Continuous N/A (years)kg Continuous N/A (years)

Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Weight [Continuous]

Premenarcheal girls (mean age = Weight

[Continuous]Premenarcheal girls (mean age = Total body BMC

[Continuous]All Participants [All articipants Total body BMC






[Continuous]Premenarcheal girls (mean age = 1,25(OH)D

[Continuous]All Participants [All articipants 1,25(OH)D

[Continuous]All Participants [All articipants 1,25(OH)D

[Continuous]All Participants [All articipants Colorectal cancer

[Reported by a Reported by a participant on a Colorectal cancer











[Reported by a Reported by a participant on a Proximal vs. distal

colon cancer Same as above (not data

Colorectal cancer (Total calcium Proximal vs. distal










Rectal cancer (Total calcium Proximal vs. distal










Colon cancer (Total calcium Proximal vs. distal










Proximal colon cancer (Total Proximal vs. distal










Distal colon cancer (Total Proximal vs. distal






Distal colon cancer (Total

Categorical N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Continuous All Participants N/A (years)Continuous All Participants N/A (years)Continuous All Participants N/A (years)Continuous All Participants N/A (years)Continuous All Participants N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)

Proximal vs. distal colon cancer

Same as above (not data

Distal colon cancer (Total Hypertension

[Self-reported by Self-reported by the health Hypertension






[Self-reported by Self-reported by the health Cancer mortality

[Based on ICD-10 Based on ICD-10 codes#Cancer mortality




[Based on ICD-10 Based on ICD-10 codes#Lung cancer


All Participants [All Participants]Lung cancer


All Participants [All Participants]Lung cancer


All Participants [All Participants]Digestive cancer


All Participants [All Participants]Breast cancer




All Participants [All Participants]Non-Hodgkin s

lymphoma/leukemBased on ICD-10 codes#

All Participants [All Participants]Colorectal cancer


All Participants [All Participants]Colorectal cancer


All Participants [All Participants]Other cancers


All Participants [All Participants]Other cancers


All Participants [All Participants]Breast cancer risk


Incident breast cancerBreast cancer risk


















Incident breast canceratopic eczema at

9 mo [modified UK modified UK Working Party

atopic eczema at 9 moatopic eczema at






atopic eczema at 9 moProstate cancer


Total prostate cancerProstate cancer














Total prostate cancerColorectal cancer

[Medical and Medical and hospital recordsColorectal cancer

[Medical and Medical and hospital records

Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)

Kg Continuous Kg Weight N/A (years)SBP [Continuous] mm Hg Continuous SBP N/A (years)DBP [Continuous] mm Hg Continuous DBP N/A (years)

Categorical All adenomas N/A (years)Categorical N/A (years)Categorical N/A (years)

nmol/L Continuous sum of D2 and D3 N/A (years)nmol/L Continuous sum of D2 and D3 N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)nmol/L Continuous N/A (years)


Kg Continuous Body weight N/A (years)SBP [Continuous] mm Hg Continuous SBP N/A (years)DBP [Continuous] mm Hg Continuous DBP N/A (years)

kg Continuous Body weight N/A (years)Categorical nd Prostate cancer N/A (years)Categorical nd Prostate cancer N/A (years)Categorical nd Prostate cancer N/A (years)Categorical nd Prostate cancer N/A (years)Categorical nd Prostate cancer N/A (years)

Colorectal cancer [Medical and

Medical and hospital recordsColorectal cancer

[Medical and Medical and hospital recordsColon cancer [ICD-

8 153.0-153.8 ICD-8 153.0-153.8 (probably registry Colon cancer [ICD-









8 153.0-153.8 ICD-8 153.0-153.8 (probably registry Weight

[Kg:Continuous]

All adenomas [For each colonoscopy

For each colonoscopy a Advance




Advanced Adenomas25(OH)D total

[sum of D2 and change in total 25(OH)D in young25(OH)D total

[sum of D2 and change in total 25(OH)D in old25(OH)D2

[Continuous]change in 25(OH)D2 in 25(OH)D2

[Continuous]change in 25(OH)D2 in old25(OH)D3

[Continuous]change in 25(OH)D3 in 25(OH)D3

[Continuous]change in 25(OH)D3 in oldRecurrent

adenomas Ascertained by complete









Recurrent adenomasAdvanced












Multiple recurrent adenomasAdvanced








Multiple recurrent adenomasBody weight

[Change in Change in bodyweight in kg

Body weight [Change in kg

Change in kg over 30 monthsProstate cancer

[nd:Categorical]Prostate cancer [nd:Categorical]Prostate cancer [nd:Categorical]Prostate cancer [nd:Categorical]Prostate cancer [nd:Categorical]

Categorical nd Prostate cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Breast cancer N/A (years)Categorical Breast cancer N/A (years)Categorical Breast cancer N/A (years)Categorical Breast cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical prostate cancer N/A (years)Categorical N/A (years)

kg/m2 Continuous BMI N/A (years)kg Continuous wt N/A (years)cm Continuous ht N/A (years)

Prostate cancer [nd:Categorical]Rectal cancer [Finish cancer

Finish cancer registry (no clear

Colorectal cancer (total Ca [mg])Rectal cancer

[Finish cancer Finish cancer registry (no clear







Colon cancer (total Ca [mg])Rectal cancer








Rectal cancer (total Ca [mg])Rectal cancer






Rectal cancer (total Ca [mg])Colorectal cancer

[Record linkage to Record linkage to cancer registries

Colorectal cancer (Total Ca [mg])Colorectal cancer








Colorectal cancer (Total Ca [mg])Colorectal Cancer


Colorectal cancer (total Ca [mg])Colorectal Cancer






Colorectal cancer (total Ca [mg])Colon caner


Colon cancer (total Ca intake Colon caner








Colon cancer (total Ca intake Colorectal cancer

[Mostly diagnosed Mostly diagnosed when Colorectal cancer



[Mostly diagnosed Mostly diagnosed when Incident breast

cancer [Self Self reported and identified through Incident breast





Breast cancer in post menopausal Incident breast








Breast cancer in pre-menopausal Incident breast






Breast cancer in pre-menopausal prostate cancer

[self-reported of self-reported of physician-prostate cancer

[self-reported of self-reported of physician-

fatal prostate cancerchange in BMI

[Continuous]change in wt [Continuous]change in ht [Continuous]

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Cerebral infarction N/A (years)Categorical Cerebral infarction N/A (years)Categorical Cerebral infarction N/A (years)Categorical Cerebral infarction N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

incident cancer [from medical

from medical record (including

incident cancer (years 1-4)incident cancer

[from medical from medical record (including









incident cancer (years 2-4)stress fractures


Stress fracture (ITT analysis)stress fractures


Stress fracture (per protocol Colorectal caner


Colorectal cancer (total Ca intake Colorectal caner






Colorectal cancer (total Ca intake Rectal caner


Rectal cancer (total Ca intake Rectal caner






Rectal cancer (total Ca intake Distal colon caner


Colon cancer (total Ca intake Distal colon caner






Colon cancer (total Ca intake Colorectal caner








Colorectal cancer (total Ca intake Rectal caner








Rectal cancer (total Ca intake Distal colon caner








Colon cancer (total Ca intake Cerebral infarction

included here Cerebral infarction included here Cerebral infarction included here Cerebral infarction included here Invasive breast cancer [Linkage

Linkage with national and

Invasive breast cancerInvasive breast

cancer [Linkage Linkage with national and







Invasive breast cancerProstate cancer














Total prostate cancer

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

ng/mL Continuous 25(OH)D N/A (years)pg/mL Continuous 1,25(OH)D N/A (years)mm Hg Continuous SBP (standing) N/A (years)mm Hg Continuous DBP (standing) N/A (years)mm Hg Continuous SBP (supine) N/A (years)mm Hg Continuous DBP (supine) N/A (years)



Prostate cancer [Tumor Gleason

Tumor Gleason score, grade,







Aggressive prostate cancerProstate cancer




















Total prostate cancer age >= 65 Prostate cancer












Aggressive prostate cancer Prostate cancer










Aggressive prostate cancer 25(OH)D

[Competitive Competitive protein binding 1,25(OH)D

[Radioreceptor Radioreceptor assay (Medgenix SBP (standing)

[Continuous]SBP (standing) [Continuous]SBP (standing) [Continuous]DBP (supine) [Continuous]Distal colon cancer [Not fully

Not fully defined (data not

Colorectal cancer (total Ca [mg])Distal colon

cancer [Not fully Not fully defined (data not







Colorectal cancer (total Ca [mg])Breast cancer


Invasive breast cancer-Breast cancer


















Invasive breast cancer-body weight

[Continuous]weight in medium (1000-body weight

[Continuous]weight in low (<713 mg/d)

cm Continuous N/A (years)cm Continuous N/A (years)mmol/L Continuous N/A (years)mmol/L Continuous N/A (years)

Categorical N/A (years)Categorical nd mortality N/A (years)

Kg Continuous Kg Weight N/A (years)BMI [Continuous] Kg/m2 Continuous BMI N/A (years)SBP [Continuous] mmHg Continuous SBP N/A (years)DBP [Continuous] mmHg Continuous DBP N/A (years)

Categorical Hypertension N/A (years)mmHg Continuous Systolic BP N/A (years)mmHg Continuous Diastolic BP N/A (years)

Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical AMI N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical Same Stroke N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical nd toxemia N/A (years)

Kg Continuous N/A (years)cm Categorical crown-heel length N/A (years)wk Continuous gestational age N/A (years)g Continuous N/A (years)g Continuous infant birth weight N/A (years)

CRC [Categorical] Categorical CRC N/A (years)CRC [Categorical] Categorical CRC N/A (years)CRC [Categorical] Categorical CRC N/A (years)CRC [Categorical] Categorical CRC N/A (years)CRC [Categorical] Categorical CRC N/A (years)

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

height [Continuous]

height in medium (1000-height

[Continuous]height in low (<713 mg/d) 25(OH)D

[Continuous]25(OH)D in medium (1000-25(OH)D

[Continuous]25(OH)D in low (<713 mg/d) First fracture

[Confirmed by Confirmed by matching every

First fracture (all sites)Mortality

[nd:Categorical]Weight [Kg:Continuous]

Hypertension [Self-report of

Self-report of medication Systolic BP

[Continuous]Systolic BP [Continuous]AMI [ICD 9 codes from national

ICD 9 codes from national death AMI [ICD 9 codes

from national ICD 9 codes from national death AMI [ICD 9 codes



from national ICD 9 codes from national death Stroke

[Same:CategoricalStroke [Same:CategoricalStroke [Same:CategoricalStroke [Same:CategoricalStroke [Same:CategoricalAdenoma recurrence [One

One or more adenomas or


recurrence [One One or more adenomas or





Adenoma recurrencetoxemia

[nd:Categorical]newborn birth weight

newborn birth weightcrown-heel length

[Categorical]gestational age [Continuous]birth weight [Continuous]

maternal weight gain 3rd trimesterbirth weight

[Continuous]

Mammography density [Ratio of

Ratio of the absolute area of

Mammographic density at age 36 Mammography


















Mammographic density at age 43

Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical preeclampsia N/A (years)Categorical N/A (years)

mmHg Continuous SBP (ITT analysis) N/A (years)mmHg Continuous N/A (years)mmHg Continuous Same as SBP DBP (ITT) N/A (years)mmHg Continuous Same as SBP DBP (per protocol) N/A (years)nmol/L Continuous 25(OH)D (ITT) N/A (years)nmol/L Continuous N/A (years)kg/m2 Continuous Weight (ITT) N/A (years)kg/m2 Continuous N/A (years)kg/m2 Continuous BMI (ITT) N/A (years)

Continuous BMI (per protocol) N/A (years)nmol/L Continuous 25(OH)D N/A (years)

Categorical prostate cancer N/A (years)Categorical prostate cancer N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical Adenoma N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Rectum cancer N/A (years)Categorical Rectum cancer N/A (years)Categorical Rectum cancer N/A (years)Categorical Rectum cancer N/A (years)Categorical Rectum cancer N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Men N/A (years)

prostate cancer [Finnish Cancer

Finnish Cancer Registry (medical prostate cancer

[Finnish Cancer Finnish Cancer Registry (medical prostate cancer




[Finnish Cancer Finnish Cancer Registry (medical fatal prostate

cancer All Participants [All articipants fatal prostate

cancer All Participants [All articipants fatal prostate

cancer All Participants [All articipants preeclampsia

[HTN (DBP 90 HTN (DBP 90 mm) and Pregnancy-

induced Pregnancy-induced SBP [Automated

OMRON electronic Automated OMRON electronic SBP [Automated

OMRON electronic Automated OMRON electronic

SBP (per protocol analysis)DBP [Same as

SBP:Continuous]DBP [Same as SBP:Continuous]25(OH)D [Continuous]25(OH)D [Continuous]

25(OH)D (per protocol)Weight (ITT)

[Continuous]Weight (ITT) [Continuous]

Weight (per protocol)Weight (ITT)

[Continuous]BMI (per protocol) [Continuous]Serum 25(OH)D change prostate cancer [biopsy or surgical

biopsy or surgical specimen; prostate cancer

[biopsy or surgical biopsy or surgical specimen; Colorectal

adenoma Reviewed the medical records Colorectal




adenoma Reviewed the medical records Distal colon






cancer Distal colon cancer Distal colon cancer Distal colon cancer Distal colon cancer Colorectal cancer [Adenocarcinoma

Adenocarcinoma (Collected for the Colorectal cancer

[Adenocarcinoma Adenocarcinoma (Collected for the Colorectal cancer






[Adenocarcinoma Adenocarcinoma (Collected for the Colon cancer [See

above (ICD180-See above (ICD180-189 only)

Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Men N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical Women N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)

mmHg Continuous SBP N/A (years)mmHg Continuous Same as SBP DBP N/A (years)nmol/L Continuous 25(OH)D N/A (years)

Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Colon cancer [See above (ICD180-

See above (ICD180-189 only)Colon cancer [See

above (ICD180-See above (ICD180-189 only)Colon cancer [See





above (ICD180-See above (ICD180-189 only)Rectal cancer [See

above (ICD199 See above (ICD199 and 209 Rectal cancer [See







above (ICD199 See above (ICD199 and 209 Colorectal cancer


Colorectal cancer (Men)Colorectal cancer










Colorectal cancer (Women)Colorectal cancer








Colorectal cancer (Women)incident prostate


total prostate cancerincident prostate


fatal prostate cancerProstate cancer

[Identified by Identified by linkage of cohort Prostate cancer









[Identified by Identified by linkage of cohort SBP [Measured

after at least 5 Measured after at least 5 min of DBP [Same as

SBP:Continuous]25(OH)D [Continuous]Colon cancer or rectal cancer

Incident cases of colon or rectal Colon cancer or

rectal cancer Incident cases of colon or rectal Colon cancer or

rectal cancer Incident cases of colon or rectal Colon cancer or

rectal cancer Incident cases of colon or rectal Distal colorectal


All Participants [All Participants]Distal colorectal






All Participants [All Participants]

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous Kg, BMI Weight N/A (years)BMI [Continuous] kg/m2 Continuous BMI N/A (years)SBP [Continuous] mm Hg Continuous SBP N/A (years)DBP [Continuous] mm Hg Continuous DBP N/A (years)

Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical Prostate cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Fatal stroke N/A (years)Categorical Fatal stroke N/A (years)Categorical Fatal stroke N/A (years)

mmHg Continuous SBP N/A (years)Continuous DBP N/A (years)

ng/mL Continuous 25(OH)D N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Colorectal cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Distal colorectal adenoma

Adenomatous polyps by review









All Participants [All Participants]Rectal adenoma

[Adenomatous Adenomatous polyps by review

All Participants [All articipants Rectal adenoma










All Participants [All articipants Distal colon












All Participants [All articipants high-risk distal

colon cancer Large (1 cm or larger), villous or





All Participants [All articipants Weight [Kg,

BMI:Continuous]

Prostate cancer [Incident cases

Incident cases identified through Prostate cancer

[Incident cases Incident cases identified through Prostate cancer



[Incident cases Incident cases identified through incident prostate


incident prostate cancerincident prostate


incident prostate cancerincident prostate


incident prostate cancerFatal stroke

[Categorical]Fatal stroke [Categorical]Fatal stroke [Categorical]SBP [BP was measured twice

BP was measured twice pre and post DBP [BP was

measured twice BP was measured twice pre and post 25(OH)D [As

measured by As measured by competitive Colorectal cancer

[Cohort members Cohort members have been Colorectal cancer




[Cohort members Cohort members have been Pancreatic cancer

[Self-reported Self-reported diagnosis in the 2-Cancer mortality


Gastrointestinal cancer mortality Cancer mortality






Gastrointestinal cancer mortality

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical Pancreatic cancer N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical N/A (years)Categorical N/A (years)

Cancer mortality [The residence at

The residence at death and the











Gastrointestinal cancer mortality All-cause mortality


All cause mortality MenAll-cause mortality










Total cancer mortality MenAll-cause mortality










All cause mortality WomenAll-cause mortality










Total cancer mortality All-cause mortality








Total cancer mortality Pancreatic cancer

[Vital status of Vital status of cohort Pancreatic cancer





[odds ratios (OR) odds ratios (OR) for pancreatic Pancreatic cancer




[odds ratios (OR) odds ratios (OR) for pancreatic Colorectal cancer

[Diagnosis of Diagnosis of primary Colorectal cancer










(excluding the 2 y All Participants [All articipants Colon cancer

(excluding the 2 y All Participants [All articipants

Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

Kg Continuous Change in kg/yr N/A (years)Categorical same as above N/A (years)Categorical same as above N/A (years)Categorical same as above N/A (years)Categorical same as above N/A (years)Categorical same as above All Causes N/A (years)Categorical same as above All Cancers N/A (years)Categorical same as above Colorectal N/A (years)Categorical same as above Respiratory N/A (years)Categorical same as above Breast N/A (years)Categorical same as above N/A (years)Categorical same as above Colorectal Cancer N/A (years)Categorical same as above N/A (years)Categorical same as above Breast Cancer N/A (years)Categorical same as above Self Reported Falls N/A (years)Categorical Respira-ry N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)Categorical Total stroke N/A (years)

CHD [Categorical] Categorical CHD N/A (years)CHD [Categorical] Categorical CHD N/A (years)CHD [Categorical] Categorical CHD N/A (years)CHD [Categorical] Categorical CHD N/A (years)

Kg Continuous Body weight in kg Body weight N/A (years)BMI [Continuous] Kg/m2 Continuous BMI N/A (years)

Categorical mortality N/A (years)Categorical nd All cause mortality N/A (years)Categorical N/A (years)Categorical Intestinal Polyp N/A (years)Categorical Kidney stone (UL) N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical Total cancer N/A (years)Categorical Cancer mortality N/A (years)

ng/mL Continuous N/A (years)Continuous at 2 mo N/A (years)

Colon cancer (excluding the 2 y

All Participants [All articipants Colon cancer



(excluding the 2 y All Participants [All articipants Rectal cancer


All Participants [All articipants Rectal cancer







(excluding the 2 y All Participants [All articipants Bodyweight

[Change in Bodyweight changeCerebrovascular

disease incidence Cardiovascular DiseaseCerebrovascular

disease incidence Ischaemic Heart DiseaseCerebrovascular

disease incidence Cerebrovascular DiseaseCerebrovascular

disease incidence IschaemicHeart DiseaseAll cancers

incidence [same All cancers incidence [same Colorectal cancer incidence [same Respiratory cancer incidence Breast cancer incidence (female) Breast cancer incidence (female)

Cancer Excluding SkinBreast cancer

incidence (female) Breast cancer incidence (female)

Respiratory CancerBreast cancer

incidence (female) Falls incidence [same as Respira-ry [Categorical]Fatal stroke [Death certificates

Death certificates & medical recordsFatal stroke

[Death certificates Death certificates & medical recordsFatal stroke

[Death certificates Death certificates & medical recordsFatal stroke

[Death certificates Death certificates & medical records

Body weight [Body weight in

mortality [by death

by death certificateAll cause mortality

[nd:Categorical]Death from colorectal cancer

Death from colorectal cancer

Death from colorectal cancerIntestinal polyps

[Intestinal polyps Intestinal polyps based on Kidney stone

[Kidney stone Kidney stone based on Cancer related


Invasive colorectal cancerCancer related


Invasive colon cancerCancer related


Invasive rectal cancerCancer related

mortality [Kidney Kidney stone based on Cancer related

mortality [Kidney Kidney stone based on vit D3 level in

mom [Continuous]mom 25 (OH)D at 1 moat 2 mo

[Continuous]

Continuous at 2 mo N/A (years)Continuous at 3 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 4 mo N/A (years)Continuous at 5 mo N/A (years)Continuous at 6 mo N/A (years)Continuous at 7 mo N/A (years)Continuous at 7 mo N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Continuous N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)Categorical CV event N/A (years)

% change Continuous PI (total) N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)% change Continuous PI (curve) N/A (years)% change Continuous Total fecal calcium N/A (years)% change Continuous N/A (years)% change Continuous N/A (years)

Categorical stroke N/A (years)Categorical stroke N/A (years)Categorical stroke N/A (years)

SBP [Continuous] mm Hg Continuous SBP N/A (years)DBP [Continuous] mm Hg Continuous DBP N/A (years)

Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)

at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]at 2 mo [Continuous]

mom vit D3 level at 1 moat 2 mo

[Continuous]antirachitic activity in milk at at 2 mo

[Continuous]infant 25 (OH)D at 1 moat 2 mo

[Continuous]infant weight at 1 moat 2 mo

[Continuous]infant length at 1 moFirst

cardiovascular MI, coronary insufficiency, First



cardiovascular MI, coronary insufficiency, PI [Change in PI%

of each of 5 Change in PI% of each of 5 PI [Change in PI%

of each of 5 Change in PI% of each of 5

PI (highest compartment)#PI [Change in PI%

of each of 5 Change in PI% of each of 5

PI (lowest compartment)#PI [Change in PI%

of each of 5 Change in PI% of each of 5 Calcium balance

[Total fecal Total fecal calcium and urinary Calcium balance


Water soluble fecal calciumCalcium balance


Total urine calciumstroke [Self-

reported and Self-reported and cross-checked by stroke [Self-

reported and Self-reported and cross-checked by stroke [Self-

reported and Self-reported and cross-checked by

Primary adenocarcinoma

Reported as diagnosis of colon Proximal (right

sided) colon Colon cancer located in cecum, Distal (left sided)

colon cancer Colon cancer located in Colorectal cancer

[The vast majority The vast majority of colorectal Colorectal cancer




[The vast majority The vast majority of colorectal Colon cancer

[Categorical]Colon cancer [Categorical]Colon cancer [Categorical]Colon cancer [Categorical]Proximal colon cancer Proximal colon cancer Proximal colon cancer Proximal colon cancer Distal colon cancer Distal colon cancer Distal colon cancer

Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical All Participants N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)Categorical N/A (years)

mmHg Continuous N/A (years)BMI [Continuous] kg/m2 Continuous All Participants N/A (years)

Categorical All Participants N/A (years)Categorical All Participants N/A (years)

mg/cm2 Continuous All Participants 12 (months)mg/cm2 Continuous All Participants 12 (months)mg/cm2 Continuous All Participants 60 (months)mg/cm2 Continuous All Participants N/A (years)nmol/L Continuous All Participants N/A (years)

Distal colon cancer Rectal cancer [Categorical]Rectal cancer [Categorical]Rectal cancer [Categorical]Rectal cancer [Categorical]

Colorectal cancer (only >2y since Rectal cancer

[Categorical]Colorectal cancer (only >2y since Rectal cancer




[Categorical]Colon cancer (only >2y since blood Rectal cancer



[Categorical]Colon cancer (only >2y since blood in SBP

[Continuous]SBP in white women

Rectal cancer [State Health

State Health Registry of Iowa, Rectal cancer

[State Health State Health Registry of Iowa, BMD [Measured at

the hip with an Measured at the hip with an BMD [Measured at

the hip with an Measured at the hip with an BMD [Measured at

the hip with an Measured at the hip with an BMD [Hip and

total body. Hip and total body. DXA25(OH)D

[Continuous]

Comparatornd nd - - -nd nd - - -nd nd - - -nd nd - - -- - OR 1.12- - OR 1.61- - OR 1.42- - OR 1.32nd nd - - -nd nd - - -nd nd - - -nd nd - - -- - - -- - - -- - - -- - - -nd nd - - -nd nd - - -nd nd - - -- - - -- - - -- - - -- - - -- - - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.43 - -- 0.72 - -- 0.72 - -- 0.72 - -- 0.72 - -- - - - -NS 0.67 Adjusted - -NS 0.67 Adjusted - -NS 0.67 Adjusted - -NS 0.67 Adjusted - -

Total vs. Total - - - -0.03 - - - -NS - - - -<0.0001 - - - -<0.0001 - - - -<0.0001 - - - -

P between groups***

P for trend****

Crude or Adjusted


Outcome effect size Quintile 2: 42.5-

51.3 nmol/L vs. Quintile 3: 51.4-60.5 nmol/L vs. Quintile 4: 60.6-71.7 nmol/L vs. Quintile 5: 71.8-129.5 nmol/L vs. quintiles based on season of

[Adjusted for age at cohort entry; quintiles based on

season of [Adjusted for age at cohort entry; quintiles based on

season of [Adjusted for age at cohort entry; quintiles based on

season of [Adjusted for age at cohort entry; Quintile 2: 42.5-

51.3 nmol/L vs. Quintile 3: 51.4-60.5 nmol/L vs. Quintile 4: 60.6-71.7 nmol/L vs. Quintile 5: 71.8-129.5 nmol/L vs. Serum 25(OH)D - Quintile 1: 12.8-

[Adjusted for age at cohort entry; Serum 25(OH)D -

Quintile 1: 12.8-[Adjusted for age at cohort entry; Serum 25(OH)D -

Quintile 1: 12.8-[Adjusted for age at cohort entry; Serum 25(OH)D -

Quintile 1: 12.8-[Adjusted for age at cohort entry; Quartile 3:

25(OH)D = 41-54 Quartile 2: 25(OH)D = 31-40 Quartile 1: 25(OH)D = < 30 Quartile cut off based on total

[crude][adjusted for HDL; SBP; BMI]Quartile cut off

based on total [crude][adjusted for HDL; SBP; BMI]Quartile cut off

based on total [crude][adjusted for HDL; SBP; BMI]25(OH)D - Group

1: >40 vs. [adjusted HDL; SBP; BMI]25(OH)D - Group

1: >40 vs. [adjusted HDL; SBP; BMI]Ca intake -

Quintile 1 vs. Ca Adjusted ( multivariate )Ca intake -











Quintile 1 vs. Ca Adjusted ( multivariate )Ca supplement vs.

Calcium placeboQuintile 1 vs. Quintile 2Quintile 1 vs. Quintile 3Quintile 1 vs. Quintile 4Quintile 1 vs. Quintile 5

Placebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dPlacebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dPlacebo vs. Vit D3 10 ug/d

<0.0001 - - - -Total vs. Total - - - -

NS - - - -NS - - - -NS - - - -NS - - - -NS - - - -NS - - - -NS - - - -NS - - - -NS 0.53 Adjusted - -NS 0.53 Adjusted - -NS 0.53 Adjusted - -NS 0.53 Adjusted - -<.05 nd Adjusted - -NS nd Adjusted - -NS nd - - -NS nd - - -NS 0.76 - - -NS 0.76 - - -NS 0.76 - - -NS 0.76 - - -0.68, 1.32 NS - - -0.50, 1.03 NS - - -0.60, 1.19 NS - - -0.63, 1.23 NS - - -nd 0.51 adjusted - -nd 0.51 adjusted - -nd 0.70 adjusted - -nd 0.70 adjusted - -nd 0.92 adjusted - -nd 0.92 adjusted - -nd 0.39 Adjusted - -nd - -nd Adjusted - -nd Adjusted - -nd Adjusted - -nd 0.39 Adjusted - -nd 0.39 Adjusted - -nd 0.39 Adjusted - -0.262 nd - - -nd nd - - -- - - - -

Cases vs. Controls 0.01 - - - -- - - - -- - - - -- - - - -- - - - -

Placebo vs. Vit D3 20 ug/d

Placebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dPlacebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dPlacebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dPlacebo vs. Vit D3 10 ug/dPlacebo vs. Vit D3 20 ug/dCa intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake Categories Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. 8851Baseline dietary Ca intake - Tertile Baseline dietary Ca intake - Tertile Baseline 25(OH)D - Tertile 1 vs. Baseline 25(OH)D - Tertile 1 vs. Baseline 1,25(OH)2D - Baseline 1,25(OH)2D - 25(OH)2D - Quintile 1 vs. 25(OH)D - Quintile 1 vs. 25(OH)D -

.04 (only data available for

Adjusted (both analyses 25(OH)D - Quintile

1 vs. 25(OH)D - .04 (only data available for 25(OH)D - Quintile

1 vs. 25(OH)D - .04 (only data available for 25(OH)D - Quintile

1 vs. 25(OH)D - .04 (only data available for 25(OH)2D -

Quintile 1 vs. 25(OH)2D - Quintile 1 vs. 25(OH)2D - Quintile 1 vs. Placebo vs. Cholecalciferol Cholecalciferol 1200 IU/day vs. Vit D + Ca vs. Placebo

Calcium vs. PlaceboCalcium vs. PlaceboCalcium vs. PlaceboCalcium vs. Placebo

- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -0.55-1.22 nd - - -0.52-1.16 nd - - -0.55-1.23 nd - - -

Quintile 5 vs. 8886 0.33-0.82 nd - - -0.45, 0.85 <.05 - - -0.55, 1.03 >.05 - - -0.47, 0.94 <.05 - - -nd 0.60 crude - -nd 0.60 crude - -nd 0.60 crude - -nd 0.60 crude - -nd NS crude - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -nd NS - - -nd nd - - -nd nd - - -nd nd - - -- - - - -- - - - -- - - - -- - - - -nd nd - - -0.96-1.53 nd - - -1.09-1.66 nd - - -1.04-1.62 nd - - -0.58 to 1.36 nd - - -0.83 to 1.90 nd - - -0.70 to 1.62 nd - - -0.45 to 1.06 nd - - -0.60 to 1.39 nd - - -- - - - -- - - - -

Vit D + Ca vs. PlaceboVit D + Ca vs. PlaceboCalcium vs. PlaceboQuintile 1 vs. Quintile 2Quintile 1 vs. Quintile 3Quintile 1 vs. Quintile 4Quintile 1 vs. Quintile 5Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5

Ca intake - Quartile 2 vs. Ca Ca intake - Quartile 3 vs. Ca Ca intake - Quartile 4 vs. Quintile 1 vs. Quintile 2Quintile 1 vs. Quintile 3Quintile 1 vs. Quintile 4Quintile 1 vs. Quintile 5Quintile 1 vs. Quintile 2-5Vit D + Ca vs. CalciumVit D + Ca vs. CalciumVit D + Ca vs. CalciumVit D + Ca vs. CalciumVit D + Ca vs. CalciumVit D + Ca vs. CalciumNo training + Ca, vit D vs. Training No training + Ca, vit D vs. Training No training + Ca, vit D vs. Training No training + Ca, vit D vs. Training No training + Ca, vit D vs. Training Training + Ca vs. No training + Ca No training + Ca + Vit D vs. Training + + Ca + Vit D vs. Vit D + No training + Ca, vit D vs. Training No training + Ca, vit D vs. Training Vit D + Ca vs. CalciumVit D + Ca vs. CalciumDairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 2 vs. Dairy Ca intake - Quartile 3 vs. Dairy Ca intake - Quartile 4 vs. Baseline 25(OH)D - Quintile 1: >= Baseline 25(OH)D - Quintile 2: 55.4 Baseline 25(OH)D - Quintile 3: 43.9 Baseline 25(OH)D - Quintile 4: 32.4 Baseline 25(OH)D - Quintile 5: < Calcium carbonate 400 IU Vit D3 Calcium carbonate 400 IU Vit D3

- - - - -- - - - -- - - - -- - - - -- - - - -

000 - nd Adjusted (age) - -- - Unadjusted - -- - Unadjusted - -- - Adjusted (age) - -- - - - -<.05 Adjusted - -<.05 - - - -<.05 - - - -NS - Adjusted - -NS - - - -NS - - - -NS NS male vs female Adjusted - -NS - - - -NS - - - -NS - Adjusted - -NS - - - -NS - - - -NS NS black vs white Adjusted - -NS - - - -NS - - - -NS - Adjusted - -NS - - - -NS - - - -- - - - -- - - - -- - - - -- - - - -

000 - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -

000 - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -

000 - - - - -- - - - -

Calcium, both weight Calcium, both weight Calcium, both weight Calcium carbonicum, Calcium carbonicum

Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Ca intake, per 1 g/day increase vs. Quartile 1 vs. Quartile 2

<.05 younger vs olderQuartile 1 vs.

Quartile 3Quartile 1 vs. Quartile 4Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Ca intake, per 1 g/day increase vs. Placebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit D

Placebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit DPlacebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit D

Placebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit DPlacebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit D

Placebo vs. Low Vit D

- - - - -- - - - -- - - - -- - - - -- - - - -

000 - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -0.53-1.63 nd - - -0.44-1.40 nd - - -0.31-1.07 nd - - -- 0.02 Adjusted - -- 0.02 Adjusted - -- 0.02 Adjusted - -- 0.02 Adjusted - -0.27-1.04 nd - - -- 0.51 Adjusted - -- 0.51 Adjusted - -- 0.51 Adjusted - -- 0.51 Adjusted - -nd 0.02 - - -nd nd - - -nd nd - - -nd nd - - -

Quintile 5 vs. 8984 nd nd - - -nd 0.30 - - -nd nd - - -nd nd - - -nd nd - - -




Placebo vs. High Vit DLow Vit D vs. High Vit DPlacebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit D

Placebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit DPlacebo vs. Low Vit DPlacebo vs. High Vit DLow Vit D vs. High Vit D25(OH)D - Quintile 2 vs. 25(OH)D - 25(OH)D - Quintile 3 vs. 25(OH)D - 25(OH)D - Quintile 4 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 5 vs. 1,25(OH)2D - 1,25(OH)2D - Quintile 1 vs. 1,25(OH)2D - Quintile 1 vs. 1,25(OH)2D - Quintile 1 vs. 1,25(OH)2D - Quintile 1 vs. Quintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5

Quintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5




Quintile 5 vs. 8984 nd nd - - -- 0.01 Adjusted - -- 0.01 Adjusted - -- 0.01 Adjusted - -1.06, 2.18 nd - - -1.07, 2.23 nd - - -1.11, 2.48 nd - - -- - - - -

6-Q1 vs. 6-Q2 nd 0.65 Adjusted - -6-Q1 vs. 6-Q3 nd 0.65 Adjusted - -6-Q1 vs. 6-Q4 nd 0.65 Adjusted - -6-Q1 vs. 6-Q5 nd 0.65 Adjusted - -6-Q1 vs. 6-Q6 nd 0.65 Adjusted - -4-Q1 vs. 4-Q2 nd 0.41 Adjusted - -4-Q1 vs. 4-Q3 nd 0.41 Adjusted - -4-Q1 vs. 4-Q4 nd 0.41 Adjusted - -2-Q1 vs. 2-Q2 nd 0.18 Adjusted - -2-Q1 vs. 2-Q2 nd 0.76 Adjusted - -2-Q1 vs. 2-Q2 nd 0.95 Adjusted - -2-Q1 vs. 2-Q2 nd 0.96 Adjusted - -3-Q1 vs. 3-Q2 nd 0.02 Adjusted - -3-Q1 vs. 3-Q3 nd 0.02 Adjusted - -3-Q1 vs. 3-Q2 nd 0.84 Adjusted - -3-Q1 vs. 3-Q3 nd 0.84 Adjusted - -

nd 0.81 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.14 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.82 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.50 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -

Quartile 1 vs. Quartile 2Quartile 1 vs. Quartile 3Quartile 1 vs. Quartile 4Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 8990< 30.0 vs. >= 30.0

Quintile 1: <18.3 ng/mL vs. Quintile Quintile 2: 18.3-<23.5 ng/mL vs. Quintile 3: 23.5-<28.3 ng/mL vs. Quintile 4: 28.3-<33.7 ng/mL vs. Quintile 5: >= 33.7 ng/mL vs. Quintile 1: <28.2 pg/mL vs. Quintile Quintile 2: 28.2-<33.5 pg/mL vs. Quintile 3: 33.5-<39 pg/mL vs. Quintile 4: 39-<46.3 pg/mL vs. Quintile 5: >= 46.3 pg/mL vs. Quartile 1:<30 nmol/L vs. Quartile Quartile 2: 30-50 vs. Quartile 3: Quartile 3: >50-75 vs. Quartile 4: >75Quartile 4: >75 vs. 9012Quartile 1: 25-D 6.3-21.3 ng/mL vs. Quartile 2: 25-D 21.4-28.4 vs. Quartile 3: 25-D 28.5-37.4 vs. Quartile 4: 25-D 37.5-77.8 vs. Quartile 1: 1,25-D 13.8-28.5 pg/mL Quartile 2: 1,25-D 28.6-33.8 vs. Quartile 3: 1,25-D 33.9-40.1 vs. Quartile 4: 1,25-D 40.2-129.1 vs. Ca (mg/1000kcal) - Quartile 1 vs. Ca Ca (mg/1000kcal) - Quartile 2 vs. Ca

nd nd - - -nd nd - - -- - - -0.05 (vs. Q1) - - -0.05 (vs. Q1) - - -- - - -

9028 vs. 9029 nd nd - - -9029 vs. 9030 nd nd - - -9030 vs. 9031 nd nd - - -9031 vs. 9032 nd nd - - -

0.13 - - -0.05 (1-sided) - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -nd 0.20 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.98 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.36 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -- - - - -- - - - -- - - - -- - - - -nd 0.51 - - -nd nd - - -nd nd - - -nd 0.90 - - -nd nd - - -

Ca (mg/1000kcal) - Quartile 3 vs. Ca Ca (mg/1000kcal) - Quartile 4 vs. 25(OH)D - Quintile 1 vs. 25(OH)D -

Adjusted (matching)25(OH)D - Quintile

1 vs. 25(OH)D - Adjusted (matching)25(OH)D - Quintile

1 vs. 25(OH)D - Adjusted (matching)25(OH)D - Quintile

1 vs. 25(OH)D - Adjusted (matching)

25(OH)D - Group 1 [0-29] vs.

Adjusted (matching)25(OH)D - Group 1

[0-19] vs. Adjusted (matching)Dairy diet vs.

Dairy free dietDairy diet vs. Dairy free dietDairy diet vs. Dairy free dietCalcium vs. PlaceboCalcium vs. PlaceboCalcium vs. PlaceboVit D2 supplment vs. 9051Vit D2 supplment vs. 9051Vit D2 supplment vs. 9051Vit D2 supplment vs. 9051Vit D2 supplment vs. 9051Vit D2 supplment vs. 9051Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9057Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9057Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9057High dairy (high Ca) vs. Control Ca supplement (prenatal) vs. zero Ca supplement (prenatal) vs. zero Vit D3 + Ca vs. Calcium1,25(OH)D - Tertile 1: 8.1-25.3 1,25(OH)D - Tertile 2: 25.4-1,25(OH)D - Tertile 3: 32.8-1,25(OH)D - Tertile 1: 13.7-1,25(OH)D - Tertile 2: 27.6-

nd nd - - -nd 0.97 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.17 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.19 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.87 - - -nd nd - - -nd nd - - -nd nd - - -

Quintile 5 vs. 9101 nd nd - - -Ref nd - - -0.67-1.95 nd - - -0.52-1.57 nd - - -0.39-1.28 nd - - -nd 0.01 - - -nd nd - - -nd nd - - -nd nd - - -

Quintile 5 vs. 9112 nd nd - - -0.51-1.19 nd - - -nd nd - - -0.63-1.41 nd - - -0.47-1.10 nd - - -nd 0.04 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.64 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.01 - - -nd nd - - -nd nd - - -nd nd - - -

Dairy Ca vs. 9124 nd 0.64 - - -Dairy Ca vs. 9124 nd 0.52 - - -

- - - - -- - - - -- - - - -

1,25(OH)D - Tertile 3: 33.0-Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9088Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9088Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9088Quintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5

Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9106Quintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5

Ca intake - Quartile 3 vs. Ca Ca intake - Quartile 1 vs. Ca Ca Intake - Quartile 2 vs. Ca Ca intake - Quartile 4 vs. Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9122Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9122Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9122

Ca enriched diet vs. Usual dietCa enriched diet vs. Usual dietCa enriched diet vs. Usual diet

nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -- - - - -- - - - -nd 0.03 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.05 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.24 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.03 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.05 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.24 - - -nd nd - - -nd nd - - -nd nd - - -0.95, 1.22 NS - - -0.96, 1.23 NS - - -0.98, 1.26 NS - - -0.98, 1.26 NS - - -Reference nd - - -0.87-1.09 nd - - -0.84-1.06 nd - - -0.83-1.04 nd - - -0.87-1.09 nd - - -nd nd - - -nd 0.91 - - -nd nd - - -nd nd - - -nd 0.74 - - -nd nd - - -nd - - -

Placebo vs. Calcium

chi2=7.3 with df 2; P<0.03 Calcium vs. Ca +

Vit DCa + Vit D vs. Ca + Vit DPlacebo vs. CalciumCalcium vs. Ca + Vit DCa + Vit D vs. Ca + Vit DCa + Vit D vs. PlaceboCa + Vit D vs. PlaceboQuartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9140Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9140Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9140Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9145Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9145Quartile 1 vs. Quartile 2Quartile 2 vs. Quartile 3Quartile 3 vs. Quartile 4Quartile 4 vs. 9145Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. 9151Ca intake - Quintile 1: <727 Ca intake - Quintile 2: 727-Ca intake - Quintile 3: 863-Ca intake - Quintile 4: 980-Ca intake - Quintile 5: >= Quartile 2 vs. Quartile 3Quartile 1: lowest 25(OH)D vs. Quartile 3 vs. Quartile 4: highest Quartile 4: highest 25(OH)D vs. Quartile 1: lowest 1,25(OH)D vs. Quartile 4: highest 1,25(OH)D vs. Low Low 25(OH)D, Low 1,25(OH)D vs. Low

0.85 (p-value for interaction)

nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.74 - - -nd nd - - -nd nd - - -nd 0.07 - - -nd nd - - -nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.95 - - -nd nd - - -nd nd - - -nd 0.26 - - -nd nd - - -nd nd - - -nd 0.68 - - -nd nd - - -nd nd - - -nd 0.03 - - -nd nd - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -Ref nd - - -0.46-1.18 nd - - -0.81-1.84 nd - - -0.60-1.43 nd - - -

Quintile 5 vs. 9176 0.81-1.82 nd - - -nd 0.14 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.17 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -- - - - -- - - - -

Low 25(OH)D, High 1,25(OH)D High 25(OH)D, Low 1,25(OH)D vs. High 25(OH)D, High 1,25(OH)D Quartile 2 vs. Quartile 3Quartile 1: lowest 25(OH)D vs. Quartile 3 vs. Quartile 4: highest Quartile 4: highest 25(OH)D vs. Quartile 1: lowest 1,25(OH)D vs. Quartile 4: highest 1,25(OH)D vs. Low Low 25(OH)D, Low 1,25(OH)D vs. Low

0.23 (p-value for interaction)Low 25(OH)D,

High 1,25(OH)D High 25(OH)D, Low 1,25(OH)D vs. High 25(OH)D, High 1,25(OH)D Quartile 2 vs. Quartile 3Quartile 1: lowest 25(OH)D vs. Quartile 3 vs. Quartile 4: highest Quartile 4: highest 25(OH)D vs. Quartile 1: lowest 1,25(OH)D vs. Quartile 4: highest 1,25(OH)D vs. Low Quartile 2 vs. Quartile 3Quartile 1: lowest 25(OH)D vs. Quartile 3 vs. Quartile 4: highest Quartile 4: highest 25(OH)D vs. Quartile 1: lowest 1,25(OH)D vs. Quartile 4: highest 1,25(OH)D vs. Low Ca supplement vs. PlaceboCa supplement vs. PlaceboCa supplement vs. PlaceboCa supplement vs. PlaceboCa supplement vs. PlaceboCa supplement vs. PlaceboQuintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5

Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Calcium vs. PlaceboCalcium vs. Placebo

- - - - -- - - - -- - - - -- - - - -

Vit D2 vs. 9187 - - - - -Vit D2 vs. 9187 - - - - -

- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -0.66-1.23 nd - - -0.47-0.88 nd - - -0.47-0.90 nd - - -- - - - -- - - - -- - - - -- - - - -

calciferol vs. 9227 - - - - -calciferol vs. 9227 - - - - -

nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -Ref=1 nd - - --0.33, 0.10 nd - - --0.27, 0.17 nd - - --0.27, 0.19 nd - - -

Quintile 5 vs. 9243 -0.32, 0.17 nd - - -Ref=1 nd - - --0.35, 0.09 nd - - --0.29, 0.17 nd - - --0.34, 0.12 nd - - -

Quintile 5 vs. 9243 -0.42, 0.09 nd - - -

Calcium vs. PlaceboCalcium vs. PlaceboCalcium vs. PlaceboCalcium vs. Placebo

Vit D + Ca vs. unsupplementedVit D + Ca vs. unsupplementedVit D + Ca vs. unsupplementedVit D + Ca vs. unsupplementedVit D + Ca vs. 9198Vit D + Ca vs. 9198Vit D + Ca vs. 9198Ca intake - Tertile 1 vs. Ca intake - Ca intake - Tertile 2 vs. Ca intake - Ca intake - Tertile 3 vs. 25(OH)D - 25(OH)D - Tertile 1 vs. 1,25(OH)2D - 1,25(OH)2D - Tertile 1 vs. 9204Ca intake - Tertile 1 vs. Ca intake - Ca intake - Tertile 2 vs. Ca intake - Ca intake - Tertile 3 vs. 25(OH)D - 25(OH)D - Tertile 1 vs. 1,25(OH)2D - 1,25(OH)2D - Tertile 1 vs. 9204Ca Intake - Quartile 1 Ca Intake - Quartile 2 Ca Intake - Quartile 3 Ca Intake - Quartile 4 Vit D + Ca vs. Placebo1.2 million IU vit D vs. Placebo1.2 million IU vit D vs. Placebo1.2 million IU vit D vs. Placebo

Ca intake - Quintile 1 Ca intake - Quintile 2 Ca intake - Quintile 3 Ca intake - Quintile 4 Ca intake - Quintile 5 Quintile 1 vs. Quintile 2Quintile 2 vs. Quintile 3Quintile 3 vs. Quintile 4Quintile 4 vs. Quintile 5


- 0.64 adj - -nd nd - - -nd nd - - -nd nd - - -- 0.64 adj - -- 0.64 adj - -- 0.52 adj - -- 0.52 adj - -- 0.52 adj - -NS nd - - -NS nd - - -

Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D3 vs. Placebo - - - - -

nd 0.68 - - -nd 0.87 - - -nd 0.06 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.20 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.24 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -

000 nd 0.39 - - -9274 vs. 9275 nd nd - - -9275 vs. 9276 nd nd - - -9276 vs. 9277 nd nd - - -000 nd 0.74 - - -9278 vs. 9279 nd nd - - -9279 vs. 9280 nd nd - - -9280 vs. 9281 nd nd - - -000 nd 0.70 - - -

Dairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 2 vs. Dairy Ca intake - Quartile 3 vs. Dairy Ca intake - Quartile 4 vs. Dairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 1 vs. Dairy Ca intake - Quartile 1 vs. Dietary Ca vs. 9253Dietary Ca vs. 9253

25 OH-D, quartile of vs. 1,25 OH-D, 1,25 OH-D, quartile of vs. Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9271Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9271Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 5 vs. 9271

9274 vs. 9275 nd nd - - -9275 vs. 9276 nd nd - - -9276 vs. 9277 nd nd - - -000 nd 0.12 - - -9278 vs. 9279 nd nd - - -9279 vs. 9280 nd nd - - -9280 vs. 9281 nd nd - - -000 nd 0.06 - - -9274 vs. 9275 nd nd - - -9275 vs. 9276 nd nd - - -9276 vs. 9277 nd nd - - -000 0.22 0.17 - - -9278 vs. 9279 nd nd - - -9279 vs. 9280 nd nd - - -9280 vs. 9281 nd nd - - -

nd nd - - -0.86-1.22 nd - - -0.89-1.31 nd - - -0.68-1.07 nd - - -0.52-0.93 nd - - -nd nd - - -0.60-0.97 nd - - -0.60-0.97 nd - - -0.57-0.94 nd - - -0.50-0.83 nd - - -nd 0.41 - - -nd 0.99 - - -nd 0.69 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.64 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -- - - - -- - - - -- - - - -nd nd - - -0.4-1.0 nd - - -0.5-1.1 nd - - -0.6-0.9 nd - - -- 0.4 Adjusted - -- 0.4 Adjusted - -- 0.4 Adjusted - -- 1.0 Adjusted - -

Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. 9287Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. 9287Ca intake (diet + supplement) vs. Ca intake (diet + supplement) vs. Ca intake - Quintile 1: =< Ca intake - Quintile 2: 470 to Ca intake - Quintile 3: 692 to Ca intake - Quintile 4: 935 to Ca intake - Quintile 5: >= Vit D intake - Quintile 1: =< 66 Vit D intake - Quintile 2: 66 to Vit D intake - Quintile 3: 136 to Vit D intake - Quintile 4: 256 to Vit D intake - Quintile 5: >= Vit D + Ca vs. CalciumVit D + Ca vs. CalciumVit D + Ca vs. CalciumCa intake - Quartile 1, median Ca intake - Quartile 2, median Ca intake - Quartile 3, median Ca intake - Quartile 4, median 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 25(OH)D - Quartile 1 vs. 25(OH)D -

- 1.0 Adjusted - -- 1.0 Adjusted - -- - - - -- - - - -- - - - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.2 Adjusted - -- 0.2 Adjusted - -- 0.2 Adjusted - -- 1.0 Adjusted - -- 1.0 Adjusted - -- 1.0 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- 0.9 Adjusted - -- - - - -- - - - -- - - - -- - - - -Reference nd - - -0.9-1.1 nd - - -0.9-1.1 nd - - -1.1-1.5 nd - - -1.0-1.6 nd - - -nd 0.99 - - -nd nd - - -

Tertile 3 vs. 9336 nd nd - - -nd NS - - -NS nd - - -NS nd - - -

Vit D vs. 9345 - - - - -Vit D vs. 9345 - - - - -Vit D vs. 9345 - - - - -

nd nd - - -0.7 1.4 nd - - -0.7 1.4 nd - - -0.6 1.3 nd - - -0.6 1.3 nd - - -nd 0.19 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -

25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 1,25(OH)D - Quartile 1 vs. 1,25(OH)D - Quartile 1 vs. 1,25(OH)D - Quartile 1 vs. 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 1,25(OH)2D - Quartile 2 vs. 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 1,25(OH)2D Ca supplement vs. 9326Ca supplement vs. 9326Ca supplement vs. 9326Ca supplement vs. 9326Ca intake - Quintile 1: =< 700 Ca intake - Quintile 2: 700 to Ca intake - Quintile 3: 1000 to Ca intake - Quintile 4: 1500 to Ca intake - Quintile 5: >= Tertile 1 vs. Tertile 2Tertile 2 vs. Tertile 3

Ca intake - Tertile 1 vs. Ca intake - Ca intake - Tertile 2 vs. Ca intake - Ca intake - Tertile 3 vs. 9340

Ca intake - Quintile 1, median Ca intake - Quintile 2, median Ca intake - Quintile 3, median Ca intake - Quintile 4, median Ca intake - Quintile 5, median Total daily calcium intake (mg) in Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca

nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -0.47-1.98 nd - - -nd 0.49 Adjusted - -nd 0.49 Adjusted - -nd 0.49 Adjusted - -nd 0.49 Adjusted - -nd 0.001 - - -nd 0.001 - - -nd 0.001 - - -nd 0.001 - - -

>65.5 vs. 9373 nd 0.001 - - -nd 0.13 crude - -nd 0.13 crude - -nd 0.13 crude - -nd 0.76 crude - -nd 0.76 crude - -nd 0.76 crude - -nd 0.69 crude - -nd 0.69 crude - -nd 0.69 crude - -nd 0.76 crude - -nd 0.58 crude - -nd 0.58 crude - -

Ca intake - Quintile 5 vs. Vit D Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Vit D Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Vit D Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Vit D Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Vit D Ca intake - Quintile 1 vs. Ca Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Vit D 25(OH)D - Quintile 1: =< 45.9 nmol/L 25(OH)D - Quintile 1: =< 45.9 nmol/L 25(OH)D - Quintile 1: =< 45.9 nmol/L 25(OH)D - Quintile 1: =< 45.9 nmol/L 25(OH)D - Quintile 1: =< 45.9 nmol/L <32 vs. >32 and <41.1>32 and <41.1 vs. >41.1 and <51.1>41.1 and <51.1 vs. >51.1 and >51.1 and <65.5 vs. >65.5

25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 1,25(OH)2D - Quartile 1 vs. 1,25(OH)2D - Quartile 1 vs. 1,25(OH)2D - Quartile 1 vs. 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 1,25(OH)2D - Quartile 1 vs. 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D -

nd 0.58 crude - -nd 0.39 crude - -nd 0.39 crude - -nd 0.39 crude - -nd 0.06 crude - -nd 0.06 crude - -nd 0.06 crude - -nd 0.04 crude - -nd 0.04 crude - -nd 0.04 crude - -- - - - -

Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -Vit D vs. Placebo - - - - -

0.79, 1.13 NS - - -0.65, 0.97 <0.05 - - -0.63, 0.96 <0.05 - - -0.56, 0.89 <0.05 - - -0.83, 1.68 NS - - -0.60, 1.37 NS - - -0.71, 1.65 NS - - -0.58, 1.50 NS - - -- - - - -- - - - -nd 0.0058 - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -

25(OH)D - Quartile 1 vs. 25(OH)D - 1,25(OH)2D - Quartile 1 vs. 1,25(OH)2D - Quartile 1 vs. 1,25(OH)2D - Quartile 1 vs. 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - Calcium vs. Placebo

Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Ca intake - Quintile 2 vs. Ca Ca intake - Quintile 3 vs. Ca Ca intake - Quintile 4 vs. Ca Ca intake - Quintile 5 vs. Calcium vs. PlaceboCalcium vs. Placebo25(OH)D, published cutoffs Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400Vit D + Ca vs. mom 400mom 400 vs. mom 6400mom 400 vs. mom 6400

- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -<.05 .01 - - -P=.05 nd - - -nd nd - - -- - - - -

Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -Calcium vs. 9427 - - - - -

nd nd - - -0.99-2.24 nd - - -0.98-2.35 nd - - -- - - - -- - - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.24 - - -nd nd - - -nd 0.005 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.36 - - -nd nd - - -nd nd - - -nd nd - - -nd 0.29 - - -nd nd - - -nd nd - - -

infant 300 vs. infant placebomom 400 vs. mom 6400mom 400 vs. mom 6400infant 300 vs. infant placebomom 400 vs. mom 6400mom 400 vs. mom 6400mom 400 vs. mom 6400infant 300 vs. infant placebomom 400 vs. mom 6400mom 400 vs. mom 6400infant 300 vs. infant placeboinfant 300 vs. infant placeboinfant 300 vs. infant placeboSevere deficiency vs. DeficiencyDeficiency vs. ReferentReferent vs. 25(OH)D <15 25(OH)D <15 ng/mL vs.

Quartile 3 + Quartile 4 vs. Quartile 2 vs. Quartile 1Quartile 1 vs. Ca supplementCa supplement vs. PlaceboCa supplement vs. PlaceboCa intake - Cumulative Ca intake - Cumulative Ca intake - Cumulative 25(OH)D - Quintile 2 vs. 25(OH)D - 25(OH)D - Quintile 3 vs. 25(OH)D - 25(OH)D - Quintile 4 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 5 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 2 vs. 25(OH)D - 25(OH)D - Quartile 3 vs. 25(OH)D - 25(OH)D - Quartile 4 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 2 vs. 25(OH)D - 25(OH)D - Quartile 3 vs. 25(OH)D - 25(OH)D - Quartile 4 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 2 vs. 25(OH)D - 25(OH)D - Quartile 3 vs. 25(OH)D -

nd nd - - -nd 0.08 - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd nd - - -nd 0.31 - - -nd nd - - -nd 0.008 - - -nd nd - - -nd nd - - -nd nd - - -

Total vs. Total - - - - -- - - - -nd 0.02 adjusted - -nd 0.02 adjusted - -- - - - -- - - - -- - - - -- - - - -- - - - -

25(OH)D - Quartile 4 vs. 25(OH)D - 25(OH)D - Tertile 1 vs. 25(OH)D - 25(OH)D - Tertile 2 vs. 25(OH)D - 25(OH)D - Tertile 3 vs. Calcium25(OH)D - Quintile 2 vs. 25(OH)D - 25(OH)D - Quintile 3 vs. 25(OH)D - 25(OH)D - Quintile 4 vs. 25(OH)D - 25(OH)D - Quintile 1 vs. 25(OH)D - 25(OH)D - Quintile 5 vs. 25(OH)D - 25(OH)D - Quartile 1 vs. 25(OH)D - 25(OH)D - Quartile 2 vs. 25(OH)D - 25(OH)D - Quartile 3 vs. 25(OH)D - 25(OH)D - Quartile 4 vs. 25(OH)D -

Calcium vs. PlaceboCalcium intake - Tertile 1 (mg/day) Calcium intake - Tertile 1 (mg/day) Vit D + Ca vs. PlaceboVit D2 + Ca vs. PlaceboVit D + Ca vs. PlaceboVit D2 + Ca vs. Ca + PlaceboVit D2 + Ca vs. Ca + Placebo

- - - - - -- - - - - -- - - - - -- - - - - -0.79-1.57 OR 1.10 0.78-1.56 - -1.16-2.22 OR 1.53 1.10-2.13 - -1.02-1.96 OR 1.33 0.95-1.86 - -0.94-1.84 OR 1.18 0.83-1.68 - -- - - - - -- - - - - -- - - - - -- - - - - -- OR 1.18 0.78-1.79 OR 1.20- OR 1.92 1.31-2.82 OR 1.96- OR 1.56 1.05-2.31 OR 1.61- OR 1.34 0.87-1.98 OR 1.37- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

CI [Adjusted


Outcome effect size

CI [Adjusted


Outcome effect size

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- 0.04 0.20 - - -- 0.04 0.20 - - -- 0.04 0.20 - - -- 0.04 0.20 - - -- - - - - -- - - - - -- - - - - -- - - - - -0.80-1.81 - 0.09 0.05 - -1.34-2.87 - 0.09 0.05 - -1.09-2.38 - 0.09 0.05 - -0.92-2.05 - 0.09 0.05 - -- - - - - -- - - - - -- - - - - -- - - - OR 0.8- - - - OR 1.3- - - - OR 1.7- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

CI [Adjusted

P for trend****

P for trend****

P for trend****


Outcome effect size

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

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- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

CI- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -0.7-2.1 - - - -- - RR 1.03 0.88,1.22 -- - RR 0.92 0.78,1.09 -- - RR 1.01 0.85,1.19 -- - RR 0.94 0.79,1.11 -- - RR 1.01 0.83,1.23 -- - RR 0.96 0.78,1.17 -- - RR 1.04 0.85,1.28 -- - RR 0.92 0.74,1.14 -- - RR 1.17 0.87,1.50 -- - RR 0.93 0.67,1.29 -- - RR 1.06 0.77,1.47 -- - RR 1.10 0.79,1.51 -- - - - - 0.0- - HR 0.98 0.62,1.54 -- - HR 0.82 0.51,1.30 -- - HR 0.73 0.45,1.19 -- - HR 0.97 0.61,1.54 -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

CI [Adjusted]

P between groups***


Outcome effect size

Net difference

Group 2 vs. 1 = NS

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - RR 1.17 0.91, 1.50 -- - RR 0.91 0.77, 1.07 -- - RR 0.89 0.76, 1.04 -- - RR 0.91 0.76, 1.09 -- - RR 1.52 nd -- - RR 0.86 nd -- - - 0.98 nd -- - - 0.91 nd -- - - 1.07 0.85,1.35 -- - - 1.05 0.83, 1.31 -- - - 1.03 0.82, 1.31 -- - - 1.04 0.83, 1.31 -- - - - - -- - - - - -- - - - - -- - - - - -- - RR 1.48 - -- - RR 1.20 - -- - RR 1.22 - -- - RR 1.32 - -- - RR 1.10 - -- - RR 1.02 - -- - RR 0.68 0.46-1.02 -- - RR 0.95 0.66-1.36 -- - RR 0.74 0.51-1.06 -- - RR 0.80 0.58-1.11 -- - RR 0.73 0.49-1.07 -- - RR 0.73 0.50-1.07 -- - RR 0.78 0.53-1.14 -- - RR 0.76 0.52-1.11 -- - - - - -- - - - - -- - - - - 39.2- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - +1.2- - - - - nd- - - - - +0.4- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - OR 2.3 0.7-7.8 -- - OR 2.3 0.7-7.7 -- - OR 0.6 0.1-2.5 -- - OR 2.4 0.8-8.2 -- - OR 1.9 0.7-5.5 -- - - - - 0.06- - - - - 0.15- - - - - 0.03- - - - - 0.04- - - - - -0.12- - - - - -0.54- - - - -- - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - 0.9- - - - - 1.5- - - - - 11.4- - - - - -- - - - - -- - - 29.8% - -- - - ~27% (figure) - -- - - ~25% (figure) - -- - - 21.3% - -- - - - - -- - - 0.89 0.81,0.97 -- - - 0.79 0.66,094 -- - - 0.70 0.54,0.91 -- - - 1.01 0.94,1.08 -- - - 1.02 0.89,1.18 -- - - 1.04 0.84,1.28 -- - - 0.98 0.89, 1.08 -- - - 0.96 0.79, 1.17 -- - - 0.95 0.70, 1.28 -- - - 0.96 0.89, 1.03 -- - - 0.92 0.80, 1.07 -- - - 0.87 0.71, 1.11 -- - - 0.94 0.82, 1.09 -- - - 0.86 0.67, 1.19 -- - - 0.84 0.55, 1.29 -- - - 0.97 0.91, 1.04 -- - - 0.94 0.83, 1.08 -- - - 0.92 0.75, 1.12 -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - OR 0.93 - -- - - 0.79 - -- - - 0.58 - -- - - 0.53 - -- - - - - -- - OR - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - 1.52 1.06, 2.18 -- - - 1.55 1.07, 2.23 -- - - 1.66 1.11, 2.48 -- - - - - -- - - - - -- - - - - -- - - - - -- - HR 1.22 - -- - HR 1.02 - -- - HR 1.00 - -- - HR 0.92 - -- - HR 1.49 - -- - HR 0.78 - -- - HR 0.65 - -- - HR 1.14 - -- - HR 1.42 - -- - HR 0.28 - -- - RR 0.91 - -- - HR 1.34 - -- - HR 0.44 - -- - HR 0.28 - -- - HR 1.83 - -- - HR 1.86 - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - OR 0.48 - -- - OR 0.25 - -- - OR 0.21 - -- - OR 0.73 - -- - - - - -- - - - - -- - - - - -- - - - - -- - OR 0.5 - -- - OR 0.3 - -- - - - - +0.5- - - - - -5.44- - - - - -2.19- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -1.2- - - - -- - - - -- - - - - 0.9- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - ~+5- - - - - ~-9- - - - - -5.7- - - - - -3.5- - - - - ~-2- - - - - ~-1- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -

- - - - -- - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -1.0- - - - - -0.4- - - - - -2.5- - - - - 0- - - - - -- - - - - +0.22- - - - - +0.11- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - RR 0.81 - -- - - - - -- - - - - -- - - - - -- - RR 0.91 - -- - RR 0.91 - -- - RR 0.57 - -- - RR 0.60 - -- - RR 0.81 - -- - - - - -- - - - - -- - - - - +3.95- - - - - +3.68- - - - - +1.69- - - - - +1.55- - - - - +34.52- - - - - +34.44- - - - - +0.42- - - - - +0.76- - - - - +0.02- - - - - +0.13- - - - - 24.4- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -7.4- - - - - -0.3- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - OR 0.64 - -- - OR 0.80 - -- - OR 0.71 - -- - OR 0.64 - -

- - OR 0.58 - -- - OR 1.04 - -- - - - - -- - - - - -- - - - - -- - OR 1.35 - -- - OR 0.58 - -- - OR 1.06 - -- - OR 0.38 - -- - OR 0.34 - -- - OR 1.59 - -- - OR 0.51 - -- - OR 0.78 - -- - OR 0.60 - -- - OR 0.71 - -- - OR 0.60 - -- - OR 1.02 - -- - OR 0.67 - -- - OR 1.30 - -- - OR 0.54 - -- - - - - 0- - - - - -0.01- - - - - -2.4- - - - - -1.0- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - 0- - - - - 0- - - - - 8.6- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - OR 0.97 0.47-1.98 -- - OR 0.86 0.40-1.84 -- - OR 0.84 0.39-1.80 -- - OR 1.45 0.66-3.15 -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - RR 0.7 - -- - RR 0.8 - -- - RR 0.6 - -- - RR 1.3 - -- - RR 1.2 - -- - RR 0.9 - -- - RR 0.6 - -- - RR 0.8 - -- - RR 0.8 - -- - RR 1.7 - -- - RR 0.8 - -- - RR 1.2 - -

- - RR 1.2 - -- - RR 0.7 - -- - RR 1.0 - -- - RR 0.5 - -- - RR 0.9 - -- - RR 0.8 - -- - RR 0.4 - -- - RR 0.8 - -- - RR 0.4 - -- - RR 0.3 - -- - - - - -0.2- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - 0.8- - - - - 0.2- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - -- - - - -

- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - nd- - - - - nd- - - - - nd- - - - - nd- - - - - +1807- - - - - +206- - - - - +10- - - - - -- - - - - -- - - - - -- - - - - ~-0.5 (figure)- - - - - ~+0.3 (figure)- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - 9- - - - - -0.05- - RR 0.90 0.61-1.33 -- - RR 0.59 0.37-0.94 -- - - - -- - - - - 1.2%- - - - - 2.2%- - - - - 0.3%- - - - - 34%

P between CI/SE/SD **- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -ND Not significant - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - -- - - - - -- - - - - -- - - - - -- - - - - -

Net difference

Net difference**

Unadjusted - Result

Unadjusted - 95% CI

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nd NS - - - -nd <0.001 - - - -

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- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - 0.4-1.3 - -- - - 0.4-1.3 - -- - - 0.3-1.1 - -- - - 0.8-2.4 - -- - - 0.7-2.2 - -- - - 0.5-1.7 - -- - - 0.3-1.2 - -- - - 0.4-1.6 - -- - - 0.4-1.6 - -- - - 0.8-3.4 - -- - - 0.3-1.8 - -- - - 0.5-2.8 - -

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Unadjusted - P btw

Adjusted - Result

Adjusted - 95% CI

Adjusted - P btw

Result [Unadjuste

95% CI [Unadjuste

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to main analysis

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- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Outcome effect size

CI / SE / SD ** [Adjusted

P for trend****

Net difference

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- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -0.64 nd -0.75 nd -0.68 nd -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

Nd comparable to main analysisNd comparable to main analysisNd comparable to main analysis

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- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -

- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - -- - - 0.5%- - - 0.6%- - - 1.1%- - - -- - - -

Study ID:EF ID Creator Create Date PMIDLast Updated

Alt ID(s) Title Year Author

Outcome Units Subgroup ArmOutcome Type

Outcome Description

Comparator No results

Documents

srdr.ahrq.gov€¦ · XLS file · Web view · 2014-10-29Project ID (SRDR) 135 Creator Gaelen Adam Organization Brown University Title The Relationships of Vitamin D and Calcium