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SPPA 2050 Speech Anatomy & Physiology
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The Central Nervous System
SPPA 2050 Speech Anatomy & Physiology
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OutlineI. Anatomy of the Nervous System
II. Afferent and Efferent Pathways
III. Centers and Circuits for the Neural Control of Speech
SPPA 2050 Speech Anatomy & Physiology
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System
ii. Peripheral Nervous System
iii. Nourishment and Protection
SPPA 2050 Speech Anatomy & Physiology
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Ganglia (Nuclei)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Basic CNS Organization
I. Spinal cord
II. Braina. Hindbrain
Medulla Pons Cerebellum
b. Midbrain
c. Forebrain Thalamus Hypothalamus Basal ganglia Cerebrum
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Basic CNS Organization
I. Spinal cord
II. Braina. Hindbrain
Medulla Pons Cerebellum
b. Midbrain
c. Forebrain Thalamus Hypothalamus Basal ganglia Cerebrum
brainstem
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Basic CNS Organization
CNS is made up of gray matter and white matter
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White matter
• Contains axons that communicate between CNS structures• Why white?
• Contains myelin (which is fatty) which insulates axons• When you think white matter, think connections between
brain regions.
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Gray matter
• contains cell bodies and synapses that allow communication between neurons.
• Place of integration/modulation of CNS activity.• Nucleus: collection of CNS cell bodies• When you think gray matter, think cell bodies &
synapses between individual neurons.
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White and gray matter
White matter,
Gray matter
Transverse Section of Brain
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White and gray matter
White matter, which stains dark(Weigert stain)
Gray matter, which stains light
Cross-Section of Caudal Brainstem
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Basic CNS Organization• The CNS is generally “symmetric”
Cross-Section of Brainstem (Level 3)
sinistral dextral
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Nuclei (Basal Ganglia)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Cerebral Hemispheres
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Cerebral Hemispheres
• Largest part of the brain• wrinkled surface or cortex (bark)
– ↑ ↑ ↑ surface area– Principally gray matter (synapses)– organized in layers
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Cerebral Cortex: Basic Structure
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Cerebral Cortex: Basic Structure
• Gyrus– outfolding of cortex
• Sulcus/fissure– infolding of cortex
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Cerebral Hemispheres
Longitudinal fissure
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Lobes of Cerebral Cortex
Figure 39.12
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Insula: Lobe or region?
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Sulci & Brodmann Areas
Figure 39.11
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Relation between anatomy and function
Kent (1997)
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Communicating between brain structures
• Performed by axonal fibers (i.e. white matter)
• Fasciculi – bundles of axonal fibers
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Communicating between brain structures
Types of fibers• Association fibers
– connect cortical areas in the same hemisphere• short (i.e. gyrus to next gyrus) • long (i.e. connecting lobes)
• Commissural fibers– connect hemispheres
• Projection fibers– Projects to/from the brainstem and spinal cord
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Some fasciculi of the cerebral cortex(long association fibers)
Kent (1997)
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Commissural fibers of the cerebral cortex
• Corpus callosum• Anterior commissure• Middle commissure• Posterior commissure
Figure 39.31
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Corona radiata & internal capsule
Figure 39.8
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Ganglia (Nuclei)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Basal ganglia (nuclei)
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Basal ganglia (nuclei)
A collection of nuclei including• caudate nucleus• putamen • globus pallidus• subthalamic nucleus• substantia nigra
• putamen + globus pallidus = lentiform nucleus• caudate nucleus + putamen = corpus striatum
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Basal ganglia (nuclei)Caudate nucleus
head
body
tail
Lentiform nucleus
Netter
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Basal ganglia (nuclei)
Figure 39.9 Transverse Figure 39.7 Coronal
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Basal ganglia (nuclei)Function
• involved in movement control
• Does not directly connect to motorneurons
• Helps stabilize the motor system
Diseases
• Parkinson’s Disease
– reduced movement
• Huntington’s Chorea
– uncontrolled “dancing” like movement
• Hemiballismus
– Uncontrolled rapid movements
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Nuclei (Basal Ganglia)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Thalamus
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Thalamus
Figure 39.9 Transverse Figure 39.7 Coronal
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Thalamus
Figure 39.16
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Thalamus
Netter
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ThalamusBasic Anatomy• Is a collection of nuclei• All sensory information (exception olfaction) passes through
thalamus en route to cerebral cortex• Information from basal ganglia and cerebellum reaches cortex via
the thalamus• “gateway to the cortex”
Function• integration site for
– Sensory information from different modalities– Complex behavior (language)– Motor processes– Emotional circuits
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Thalamic nuclei• Anterior & mediodorsal nuclei
– Connected to emotional circuits
• Ventral anterior and ventral lateral nuclei– input from basal ganglia and cerebellum
• Ventral posterior lateral (VPL) and medial (VPM)– relays general sensory information from body (VPL) and
head (VPM)
• Medial geniculate body– Relays/processes auditory information
• Lateral geniculate body– Relays/processes visual information
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Hypothalamus
Figure 39.16
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HypothalamusBasic Anatomy• Located inferior to the thalamus (hence “hypo”)
Function• Controls ‘autonomic behavior such as
– release of hormones– control of food and water intake– sexual behavior– sleep cycles– emotional responses
• Indirect role in speech (unless you include flirting)
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Nuclei (Basal Ganglia)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Cerebellum
Figure 39.6
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Cerebellum & Brainstem
Figure 39.6
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Cerebellum
• Cerebellum ~ “little brain”• Contains ~ ½ neurons in the entire brain• Attached to dorsal brainstem by peduncles
– Inferior cerebellar peduncle– middle cerebellar peduncle– superior cerebellar peduncle
SPPA 2050 Speech Anatomy & Physiology
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Cerebellar peduncles(new slide)
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Cerebellum
• White matter– Fibers going into and out of the cerebellum via peduncles
• Gray matter– Cerebellar cortex– deep cerebellar nuclei
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Cerebellar gray matter(new slide)
From Netter
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CerebellumCerebellar cortex
What is it?– Primary information receiving areaHow is information received? – Inferior and middle cerebellar pedunclesWhere does the information come from? – other motor control centers– vestibular system (balance)– Information about body position via brainstem
and spinal cord
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CerebellumDeep Cerebellar Nuclei
What is it?– Primary information sending areaHow does it send information?– superior cerebellar peduncleWhere does it send information?– brainstem and spinal cord– Cerebral cortex via thalamus
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Function• Coordinates muscles for smooth fluid motion• Monitors “state” of body in space• Monitors/adjusts motor commands Cerebellar Disease/damage• can result in “ataxia”
– Decomposition of movement– Errors in timing and scaling of movement– Tremor during movement activities
Cerebellum
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Nuclei (Basal Ganglia)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Limbic System
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Limbic System
Figure 39.13
HippocampusFornixMammillary bodyAmygdala
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Limbic SystemFunction
• Important in regulating emotional and visceral responses
• role in speech/language unclear– damage in the area can cause mutism
(lack of any speech)
SPPA 2050 Speech Anatomy & Physiology
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OutlineI. Anatomy of the Nervous System
i. Central Nervous System• Basic Organization• Cerebral Hemispheres• Basal Nuclei (Basal Ganglia)• Thalamus & Hypothalamus• Cerebellum• Limbic System• Brainstem• Spinal Cord
SPPA 2050 Speech Anatomy & Physiology
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Midbrain
Pons
Medulla
Brainstem: ventral
Figure 39.19
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Midbrain
Pons
Medulla
Brainstem: Dorsal Lateral
Figure 39.19
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Midbrain
Pons
Medulla
Brainstem: dorsal
Figure 39.19
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BrainstemBasic Anatomy• Contains• Projection fibers (called tracts)
– To higher CNS structures from SC/BS– To SC/BS from higher CNS structures
• Nuclei– Associated with cranial nerves– Associated with basic bodily function
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BrainstemFunction• Cranial nerve nuclei
– Motor supply to muscles of speech– Sensory supply to head and neck
• Regulates some essential life functions– Body temperature– Respiration– Swallowing– Digestion
SPPA 2050 Speech Anatomy & Physiology
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Superior orbital fissure (CN V: ‘V1’)
Foramen rotundum (CN V: ‘V2’)Foramen ovale (CN V: ‘V3’)
Internal auditory meatus (CN VII & VIII)
Jugular foramen (CN IX, X, XI)
Hypoglossal canal (CN XII)
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Cranial Nerve Nuclei
Figure 31.2
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Where do cranial nerves arise?
Pons• CN V – sourced to a number of BS nuclei• CN VII –motor portion from Facial nucleus
Medulla• CN IX, X, XI – originate largely in nucleus ambiguus• CN XII – originates in Hypoglossal nucleus