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Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012) Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize preprint. Food and Chemical Toxicology, ---, ---, pp --- www.elsevier.com/locate/foodchemtox AND http://dx.doi.org/10.1016/j.fct.2012.08.005 AND http://www.ask-force.org/web/Seralini/Seralini-Long-Term-Toxicity-RR-2012.pdf AND http://www.ask-force.org/web/Seralini/Seralini-Press-Sustainable-Trust-20120919.pd

Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

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Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012) - PowerPoint PPT Presentation

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Page 1: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize preprint. Food and Chemical Toxicology, ---, ---, pp --- www.elsevier.com/locate/foodchemtox AND http://dx.doi.org/10.1016/j.fct.2012.08.005 AND http://www.ask-force.org/web/Seralini/Seralini-Long-Term-Toxicity-RR-2012.pdf AND http://www.ask-force.org/web/Seralini/Seralini-Press-Sustainable-Trust-20120919.pdf

Page 2: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize preprint. Food and Chemical Toxicology, ---, ---, pp --- www.elsevier.com/locate/foodchemtox AND http://dx.doi.org/10.1016/j.fct.2012.08.005 AND http://www.ask-force.org/web/Seralini/Seralini-Long-Term-Toxicity-RR-2012.pdf AND http://www.ask-force.org/web/Seralini/Seralini-Press-Sustainable-Trust-20120919.pdf

Page 3: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Seralini’s research and the way it is published raise serious ethical questions.

As pointed out by antivivisection groups, this poorly-conducted and cruel experiment causingsuffering for no meaningful scientific purpose is unacceptable. http://www.buav.org/article/1112 .Despite the flaws in the research, Séralini et al widely publicised their unsubstantiated conclusions inan unscientific and scaremongering campaign with anti-biotech groups and some politicians.

Page 4: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)
Page 5: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

The wrong use of rats: Sprague-Dewey Rats are highly prone to spontaneous tumors

even more when fed ad libitum as recommended by Séralini

Page 6: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Eldridge, J.C., Wetzel, L.T., Stevens, J.T., & Simpkins, J.W. (1999)The mammary tumor response in triazine-treated female rats: A threshold-mediated interaction with strain and species-specific reproductive senescence. Steroids, 64, 9, pp 672-678 http://www.ask-force.org/web/Seralini/Eldridge-Mammary-Tumor-Sprague-F344-1999.pdf

Demonstrates the systemic mistakes in results you get whenusing Sprague-Dawleyrats

Page 7: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Ross, M.H. & Bras, G. (1965)TUMOR INCIDENCE PATTERNS AND NUTRITION IN RAT. Journal of Nutrition, 87, 3, pp 245-& <Go to ISI>://WOS:A19656943000001 AND http://www.ask-force.org/web/Seralini/Ross-Tumor-Incidence-Patterns-Nutrition-1965.pdf

Reduced caloric intake reduces tumor incidence

Slide by K. Ammann

Limiting the number of calories reduces tumor incidence. Seralini allowed rat feeding ad libitum (no restriction)

Page 8: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Burns-Naas, L.A., Zorbas, M., Jessen, B., Evering, W., Stevens, G., Ivett, J.L., Ryan, T.E., Cook, J.C., Capen, C.C., Chen, M., Furman, G., Theiss, J.C., Webber, S., Wu, E., Shetty, B., Gasser, R., & McClain, R.M. (2005)Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia. Human & Experimental Toxicology, http://www.ask-force.org/web/Seralini/Burns-Naas-Increase-thyroid-2005.pdf

Figure 2

Adjusted survival curves for male rats(top panel) andfemale rats (bottom panel) in the 2-year carcinogenicitystudy with nelfinavir.

Page 9: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Durbin, P.W., Williams, M.H., Jeung, N., & Arnold, J.S. (1966)DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS OVER LIFE-SPAN OF FEMALE CHARLES RIVER (SPRAGUE-DAWLEY) RAT - INFLUENCE OF OVARIECTOMY THYROIDECTOMY AND ADRENALECTOMY-OVARIECTOMY. Cancer Research, 26, 3P1, pp 400-& http://www.ask-force.org/web/Seralini/Durbin-Development-Spontaneous-Mammary-Tumors-1966.pdf

Page 10: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Durbin, P.W., Williams, M.H., Jeung, N., & Arnold, J.S. (1966)DEVELOPMENT OF SPONTANEOUS MAMMARY TUMORS OVER LIFE-SPAN OF FEMALE CHARLES RIVER (SPRAGUE-DAWLEY) RAT - INFLUENCE OF OVARIECTOMY THYROIDECTOMY AND ADRENALECTOMY-OVARIECTOMY. Cancer Research, 26, 3P1, pp 400-& http://www.ask-force.org/web/Seralini/Durbin-Development-Spontaneous-Mammary-Tumors-1966.pdf

Page 11: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Sprague–Dawley rats were used briefly by the NCI both in exploratoryprojects and some early carcinogenicity bioassays, but the‘‘large size and .numerous spontaneous tumors in this strain’’ wereconsidered detrimental characteristics compared to perceivedadvantages with F344 rats Weisburger, J.H., Williams, G.M., 1981. Carcinogen testing: current problems and new approaches. Science 214, 401–407Hayes Wallace A., Dayan, A.D., Hall, W.C., Kodell, R.L., Williams, G.M., Waddell, W.D., Slesinski, R.S., & Kruger, C.L. (2011)A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients. Regulatory Toxicology and Pharmacology, 60, 1, Supplement, pp S1-S34 http://www.sciencedirect.com/science/article/pii/S0273230010001819 AND http://www.ask-force.org/web/Seralini/Hayes-Review-Mammalian-Carcinogenicity-Study-Design-2011.pdf

Page 12: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

EFSA-Statement (20121004)Review of the Séralini et al. (2012) publication on a 2-year rodent feeding study with glyphosate formulations and GM maize NK603 as published online on 19 September 2012 in Food and Chemical Toxicology EFSA Journal, 2012;10(10):2910 pp 1-9 Press release: http://www.efsa.europa.eu/en/press/news/121004.htm AND Assessment: http://www.efsa.europa.eu/en/efsajournal/doc/2910.pdf AND EFSA-Letter to Seralini: http://www.efsa.europa.eu/en/edinterviews/docs/corporateSeralini121004.pdf AND http://www.ask-force.org/web/Regulation/EFSA.Statement-Seralini-Journal-201210-10-2912-20121004.pdf

Page 13: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Fundamental flaws of the Seralini research and reporting.As EFSA concluded, the Seralini study is “inadequately designed, analysed and reported.”

The research has several fundamental flaws, such as extending a 90-day feeding trial to two yearswithout adjusting the design of the study, and using this particular strain of rats – whichspontaneous develops tumours – without using a statistically required number of those rats.

Page 14: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

European Court of Auditors recognises EFSA’s advanced independence policy, makes recommendationsThe European Food Safety Authority (EFSA) is applying some of the most advanced policies and procedures for declaring, assessing and managing potential conflicts of interest, the European Court of Auditors said in a review of the management of conflicts of interests in four independent agencies of the European Union. The Court has made a number of recommendations, many of which are already integrated in EFSA’s working processes. EFSA will carefully examine any recommendations which may remain outstanding.

EFSA (20121011)Electronic Source: European Court of Auditors recognises EFSA’s advanced independence policy, makes recommendations (ed EFSA European Food Safety Authority), http://www.efsa.europa.eu/en/press/news/121011.htm AND http://www.ask-force.org/web/Seralini/EFSA-Cour-Autitors-Recommendations-20121011.pdf

Page 15: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

50 ng/L 50 mg/L 2,3 g/L Glyphosate in trinking waterControll 11% 22% 33% GMO 1. Group, GMO + Glyphosate 2. Group

Mammary tumors

Mammary glands

Hepato-digestive tract

Liver Kidney

Pat

holo

gies

0

0.2

0.4

0.6

0.8

1

1.2

1.4Pathologies per animal in relation to the whole group

Prof. Dr. Klaus Jany, data from Euro/Biotech/News: 10, Vol. 11,2012

Page 16: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Jany Klaus (2013), Critical remarks on the long-term feeding study by Séralini et al. (2012). Does the study provide proof of health threats posed by genetically modified foods?, EFFL - European Food and Feed Law Review, 3, pp. 176-187,http://www.ask-force.org/web/Seralini/Jany-Critical-Remarks-Seralini-Study-EFFL-201303.pdf

Page 17: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Jany Klaus (2013), Critical remarks on the long-term feeding study by Séralini et al. (2012). Does the study provide proof of health threats posed by genetically modified foods?, EFFL - European Food and Feed Law Review, 3, pp. 176-187,http://www.ask-force.org/web/Seralini/Jany-Critical-Remarks-Seralini-Study-EFFL-201303.pdf

Page 18: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Jany Klaus (2013), Critical remarks on the long-term feeding study by Séralini et al. (2012). Does the study provide proof of health threats posed by genetically modified foods?, EFFL - European Food and Feed Law Review, 3, pp. 176-187,http://www.ask-force.org/web/Seralini/Jany-Critical-Remarks-Seralini-Study-EFFL-201303.pdf

Page 19: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Jany Klaus (2013), Critical remarks on the long-term feeding study by Séralini et al. (2012). Does the study provide proof of health threats posed by genetically modified foods?, EFFL - European Food and Feed Law Review, 3, pp. 176-187,http://www.ask-force.org/web/Seralini/Jany-Critical-Remarks-Seralini-Study-EFFL-201303.pdf

Page 20: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Jany Klaus (2013), Critical remarks on the long-term feeding study by Séralini et al. (2012). Does the study provide proof of health threats posed by genetically modified foods?, EFFL - European Food and Feed Law Review, 3, pp. 176-187,http://www.ask-force.org/web/Seralini/Jany-Critical-Remarks-Seralini-Study-EFFL-201303.pdf

Page 21: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Effects of Roundup alone:Roundup was administrated in drinking water at 3 increasing doses, same symbols (environmental (A), MRL in agricultural GMOs (B) and half of minimal agricultural levels (C), see Section 2).

Diet with conventional isogenic maize and water with Roundup

In some cases the higher dose with positive effects!

Other examples of strange behavior (effect NOT proportional to the dose)

Page 22: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

All public authorities that examined Seralini’s study have rejected it, except ENSSER

Many public authorities, including the European Food Safety Authority (EFSA), the German FederalInstitute for Risk Assessment and the French Haut Conseil des Biotechnologies, have reviewed thestudy and all come to a similar conclusion: the research of Séralini et al was so flawed that theconclusions have no basis. The reviews of these authorities can be found on:http://www.prri.net/qa-seralini-et-al-2012/

37 official units published rebuttals

Page 23: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Over 35 Agencies have written contradictions

Australia & New Zealand – Food Standards (FSANZ) – (link)Belgium – Biosafety Council – (link)Brazil – Nat. Techn. Commission on Biosafety (CTNBio) – (link)Canada – Health Canada, Food Inspection Agency – (link)Denmark – National Food Institute – (link)EFSA – European Food Safety Authority (EFSA) – (link)France – High Council of Biotechnologies (HCB) – (link)France – National Sanitary Safety Agency (ANSES) – (link)Germany – Federal Institute for Risk Assessment (BfR) – (link)Netherlands – Food and goods authority (VWA) – (link)Romania – Food Safety Authority (ANSVSA) – (link)

Page 24: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)
Page 25: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

BfR-Bund (20120928)Veröffentlichung von Seralini et al. zu einer Fütterungsstudie an Ratten mit gentechnischverändertem Mais NK603 sowie einer glyphosathaltigen Formulie-rung (eds BUND), pp. 8. German Government, Berlin, Germany

http://www.bfr.bund.de/de/presseinformation/2012/29/studie_der_universitaet_caen_ist_kein_anlass_fuer_eine_neube_wertung_von_glyphosat_und_gentechnisch_veraendertem_mais_nk_603-131728.html AND http://www.ask-force.org/web/Seralini/BfR-bund-Stellungsnahme-Seralini-20120928.pdf AND http://www.bfr.bund.de/cm/343/veroeffentlichung-von-seralini-et-al-zu-einer-fuetterungsstudie-an-ratten-mit-gentechnischveraendertem-mais-nk603-sowie-einer-glyphosathaltigen-formulierung.pdf AND English http://www.ask-force.org/web/Seralini/BfR-bund-Position-engl-Seralini-20121001.pdf

The authors conclusions that rats fed with GM Nk603 maize throughout their life have shorter life span is notsufficiently corroborated by experiments

Page 26: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

These studies have shown that old Harlan Sprague-Dawley rats get cancers and other diseases.

What this study of Séralini does not show is that exposing these rats to GM corn and/or Roundup makes any difference to the frequency of cancers or other diseases. It can’t because no statistical tests have been applied, and perhaps most worryingly, the authors do not comprehensively report on why rats in the control group died.And most unusually: the authors refuse explicitly to present the raw data

Miller Henry I. & Chassy Bruce M. (20120925)Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http://www.forbes.com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http://www.ask-force.org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925.pdf

Page 27: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

– the investigators used a strain of rats that were bred to develop tumors as they aged (a detail they failed to disclose). Significantly, mortality rates and tumor incidence in all experimental groups fall within historical norms for this strain of laboratory rats. Therefore, the claim that the genetically engineered corn component of the diet or the herbicide caused the tumors is insupportable.

– Séralini et al. argue that the exceedingly long time-frame of their study was necessary to reveal the experimental effects, but animal researchers long ago established that such lengthy studies add no additional meaningful or valid information beyond that which can be collected in shorter times;

– there is no documentation of the rats’ food intake, which strongly affects the incidence of tumors in this strain;

– the experiment included 180 rats (9 groups of 20) fed the genetically engineered or herbicide-containing diets (the “treated rats”), while only 20 rats were fed a standard (control) diet. Both common sense and a rudimentary understanding of statistics tell you that even if there were no actual differences between the groups, the greater numbers of animals in the pooled treated groups increases the odds that one of the treated rats would die first (one of the parameters reported in the paper); Miller Henry I. & Chassy Bruce M. (20120925)Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http://www.forbes.com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http://www.ask-force.org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925.pdf

Page 28: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

– the statistical methods employed were unconventional and appeared to be selected specifically in order to give a certain result. Tom Sanders, head of the nutritional sciences research division at King’s College London, called the treatment of data “a statistical fishing trip”;

– absence of statistical analysis for mortality or tumor incidence. Statistical analysis is a basic requirement of scientific research, and given that the claims of the study allege tumor and mortality effects, the omission of statistical analysis is inexcusable;

– the investigators have refused to release all the data from the experiment, which constitutes scientific misconduct;

– insufficient information is provided about the source and quality of corn varieties used in the rats’ diet (contamination with molds could be a critical factor);

– absence of data concerning liver or kidney histopathology and liver function tests; – insufficient explanation of the absence of a dose-response relationship between the

experimental variables and supposed effects; – inappropriate, unnecessary suffering of the rats, which should have been euthanized

long before the tumors became so huge – an especially egregious ethics violation given that the study is, in any case, worthless.

– the reported results conflict with innumerable experiments conducted by laboratories around the world on both genetically engineered corn and glyphosate, and also with vast real-world experience.

Miller Henry I. & Chassy Bruce M. (20120925)Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http://www.forbes.com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http://www.ask-force.org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925.pdf

Page 29: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Number of rats: Seralini’s manipulation:The OECD guidelines 451 (carcinogenicity studies) states clearly:50 rats. Séralini cites OECD guideline 452 (chronic toxicity studies), where it is stated: 20 rats per sex, per group, total at least 40 ratsSeralini refers wrongly to OECD 452 and even citing it with wrong numbers, thus justifying his use of 10 rats.

With just 10 rats, the results are heavily influenced by sampling, The study is flawed also in samplingOECD Guideline 451 (20090908)Test No. 451: Carcinogenicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects pp 15 http://www.oecdbookshop.org/oecd/display.asp?lang=EN&sf1=identifiers&st1=5lmqcr2k7mq4 AND http://www.ask-force.org/web/OECD/OECD-Carcinogenicity-Studies-Guideline-451-20090907.pdf

OECD Guideline 452 (20090908) OECD Test No. 452: Chronic Toxicity Studies OECD, IS: ISBN: 9789264071209 , OECD Code: 979945201E1 pp http://www.oecdbookshop.org/oecd/display.asp?lang=EN&sf1=identifiers&st1=5lmqcr2k7mlw AND http://www.ask-force.org/web/OECD/OECD-Guideline-452-adopted-Chronic-Toxicity-20090907.pdf

Page 30: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

A collection of links of rebuttals coming in the first few daysKeogh, B. (2012)Biotech Crops Seal of Safety Does Not Convince Skeptics. Journal of the National Cancer Institute, pp http://jnci.oxfordjournals.org/content/early/2012/03/22/jnci.djs196.short AND http://www.ask-force.org/web/Seralini/Keogh-Biotech-Crops-Seal-Safety-2012.pdf

Koerth-Baker Maggie (20120921)Electronic Source: Authors of study linking GM corn with rat tumors manipulated media to prevent criticism of their work published by: http://boingboing.nethttp://boingboing.net/2012/09/21/authors-of-study-linking-gm-co.html AND http://www.ask-force.org/web/Seralini/Koerth-Baker-Authors-Manipulted-Media-20120921.pdf

Morandini Piero (20120920)Letter to the Editor Prof. Hayes of Food and Chemical Toxicology, related to Seralini-Study. Food and Chemical Toxicology, --, --, pp -- http://www.ask-force.org/web/Seralini/Morandini-Letter-to-Editor20120920.pdf

Ng Ashley (20120925)Electronic Source: Genetically modified corn and cancer - what does the evidence really say? , The Conversation, Academic Rigour, Journalistic Flairhttps://theconversation.edu.au/genetically-modified-corn-and-cancer-what-does-the-evidence-really-say-9746

Revkin Andrew C. (20120921)Electronic Source: Group Promoting Rat Study of Engineered Corn Forced Coverage Rush, published by: New York Timeshttp://dotearth.blogs.nytimes.com/2012/09/21/group-promoting-rat-study-of-engineered-corn-forced-coverage-rush/ AND http://www.ask-force.org/web/Seralini/Revkin-Group-Promotion-Coverage-Rush-20120921.pdf

Scientific-Alliance (20120921)Electronic Source: Legitimate fears over GM crops? , published by: The Scientific Alliance · St John's Innovation Centre · Cowley Road · Cambridge, Cambridgeshire CB4 0WShttp://us2.campaign-archive1.com/?u=f1e3eeb023e7d88eff0dda8a2&id=2823730491&e=af721f4e26 AND http://www.ask-force.org/web/Seralini/Scientific-Alliance-Seralini-Newsletter-20120921.pdf

Kuntz, M. (2011)Electronic Source: Seralini Critique: The latest opus of «parallel science » of Criigen from March 2011 (ed M. Kuntz), Parallel Sciencepublished by: Marcel Kuntzhttp://ddata.over-blog.com/xxxyyy/1/39/38/37/Critical_views_on_Seralini_20110710.pdf

Miller Henry I. & Chassy Bruce M. (20120925)Scientists Smell A Rat In Fraudulent Genetic Engineering Study Forbes, OP-ED, pp 4 http://www.forbes.com/sites/henrymiller/2012/09/25/scientists-smell-a-rat-in-fraudulent-genetic-engineering-study/ and http://www.ask-force.org/web/Seralini/Miller-Scientists-Smell-Rat-Fraudulent-20120925.pdf

Page 31: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Comparison short-long term reveals chaotic Study Plan

Page 32: Seralini Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, & Joel Spiroux de Vendomois (2012)

Séralini‘s false claim that Monsanto study didnot give in 2006 study the precise amounts of test feedsWrong, since Hammond 2006referred explicitly to his previous Study from 2004<< fig. from 2004 study

Hammond, B., Dudek, R., Lemen, J., & Nemeth, M. (2004)Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn. Food and Chemical Toxicology, 42, 6, pp 1003-1014 http://www.ask-force.org/web/Seralini/Hammond-Results-13-week-safety-assurance-glyphosate-2004.pdf AND Certified Rodent diet 5002: http://labdiet.com/pdf/5002.pdf

Hammond, B.G., Dudek, R., Lemen, J.K., & Nemeth, M.A. (2006)Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn. Food and Chemical Toxicology, 44, 7, pp 1092-1099 http://www.ask-force.org/web/Seralini/Hammond-Results-90-day-MON810-2006.pdf

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14. January 2013

EFSA is today announcing the launch of a major initiative designed to facilitate access to data, enhancing transparency in risk assessment. The programme, to be developed in cooperation with the Authority’s partners and stakeholders, will consider how best and to what extent technical data used in risk assessments can be made available to the broader scientific community and interested parties.

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Riviere-Wekstein, G. (201212)Decryptage La « part d’ombre » du professeur Séralini. ae, Agriculture et Environment, 109, pp 7 http://www.ask-force.org/web/Seralini/Riviere-Gil-Seralini-partdelombre-2012.pdf AND http://www.ask-force.org/web/Seralini/Riviere-Gressel-Dark-Side-Seralini-ae-Dec-2012.pdf

The “dark side”of Professor Séralini

Of the many people in the entourage of Professor Gilles-Eric Séralini, thereare his friends from Sevene Pharma, a discreet company owned by the leaders of a strange movement.

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Seralini’s self proclaimed independence of research is a hoax.The main defence of Seralini et al after the massive criticisms of their work was accusing those who criticised of not being independent, and proclaiming themselves as ‘independent’ This is a hoax.

Apart from the widespread issued concerns about Seralini’s ties with companies, anti-biotech NGOs and politicians, we should remember that criticisms on the work of Seralini et al by individual scientists, academic establishments, research institutes, national bodies and EFSA are based onscience.

As said by Olivier Godard, Research Director at the French public institute CNRS, during ahearing at the French National Assembly on 19 November 2012,

“the right question to ask to ensure the independence of collective expertise is not ‘tell me to who you are linked to…’ but ‘what are the arguments that justify your viewpoint….’.”

Olenyi Sebastian (20120228)Electronic Source: GM crops: Forget the money, follow the science (ed S. Olenyi), published by: The BTS blog of the Biotechnology and Society group of the TU Delft and Euractivhttp://www.euractiv.com/cap/gm-crops-follow-money-analysis-510724#comment-2945 AND http://www.ask-force.org/web/Fundamentalists/Olenyi-GM-Crops-Forget-Money-Follow-Science-20120228.pdf

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Authors’ contributions CG carried out the cellular, biochemical and molecular studies, participated in drafting the manuscript. NB and EC reproduced and helped the cellularexperiments. CT participated in the methodological and protocol advices,and discussions. FL initiated the collaboration in Sevene Pharma andcarefully followed the first sets of experiments for the protocol design. CLparticipated in Dig1 conception and discussions. CDL directed Dig1 assessment for Sevene Pharma and GES conceived the study, the finalversion of the manuscript, participated in the design of the work and wasresponsible for the coordination. All authors read and approved the finalmanuscript.Competing interestsThe authors declare that they have no competing interests. Thedevelopment of Dig1 in Sevene Pharma was performed completelyindependently of its assessment. The scientists in the University of Caen incharge of the assessment of xenobiotics or plant extracts declare nofinancial or other interests in the development of these products.

Gasnier, C., Benachour, N., Clair, E., Travert, C., Langlois, F., Laurant, C., Decroix-Laporte, C., & Seralini, G.-E. (2010)Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. Journal of occupational medicine and toxicology (London, England), 5, pp 29-29 http://www.ask-force.org/web/Seralini/Gasnier-Dig1-protects-against-cell-death-2010.pdf

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CRIIGEN’s website credits the Professor with being recently named the "International Scientist of the year 2011" in a bogus certificate awarded by the International Biographical Centre of Cambridge, England.The InternationalBiographical Centre has nothing to do with Cambridge University.

Edwards, I.B. & Beetles, C. (2012)Information about Australian Tour of G.E. Seralini in February 2012 Newspaper, Report and Fake Diploma, Stock & Land, pp (Stock & Land, Article)http://www.ask-force.org/web/Seralini/Edwards-Beetles-Seralini-Information-Sheet-Australia-2012.pdf see comment in French by Marcel Kunzt: http://www.agriculture-environnement.fr/a-la-une,6/seralini%E2%80%89-le-prix-de-l-ego,771.html

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piss off !!

Always saywhat you think!

you can only die once

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Hartung, T., van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N., & Thomas, R. (2012)Systems Toxicology. Altex-Alternatives to Animal Experimentation, 29, 2, pp 119-128 http://www.ask-force.org/web/Seralini/Hartung-Systems-Toxicology-Food-for-Thought-2012.pdf

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Yashina, S., Gubin, S., Maksimovich, S., Yashina, A., Gakhova, E., & Gilichinsky, D. (2012)Regeneration of whole fertile plants from 30,000-y-old fruit tissue buried in Siberian permafrost. Proceedings of the National Academy of Sciences, 109, 10, pp 4008-4013 http://www.pnas.org/content/109/10/4008.abstract AND http://www.ask-force.org/web/Global-Warming/Yashina-Regeneration-30000-year-Silene-stenophylla-2012.pdf

Fig. 3. Flowering plants of Silene stenophylla. (A) Plant grown in vitroculture from seed of an extant plant. (B) Plant regenerated in vitro culturefrom tissue of fossil fruit with primary strictly female flower. (C) Plantregenerated from tissue of fossil fruit with both female (f) and bisexual (b)flowers.

Silene stenophylla31‘000 years old