10TH INTERNATIONAL ISSX MEETING

September 30 – October 3, 2013Westin Harbour Castle Hotel

Toronto, Canada

Meeting Venue – Westin Harbour Castle Hotel

Proposed Meeting Organizing Committee (MOC)

Denis Grant (Chair)Univ of Toronto ON

Stelvio BandieraUBC, Vancouver BC

Jack BendUWO, London ON

Chantal GuillemetteLaval Univ, Quebec PQ

Malle Jurima-RometCelerion, Montreal PQ

Roger KeefeImperial Oil, Calgary AB

David K. LeeNoAb, Mississauga, ON

Tom MasseyQueen’s Univ, Kingston ON

Eddie MorganEmory Univ, Atlanta GA

Sandy PangUniv of Toronto, Toronto ON

Allan RettieUniv of Washington, Seattle WA

David RiddickUniv of Toronto, Toronto ON

Nathalie RiouxBoehringer Ingelheim, Laval PQ

Rachel TyndaleUniv of Toronto, Toronto ON

Jack UetrechtUniv of Toronto. Toronto ON

Peter WellsUniv of Toronto, Toronto ON

Proposed Scientific Advisory Board (SAB)

Ann Daly – Newcastle University, UK

Patrick Dansette - Université Paris, FranceXinxin Ding

– Wadsworth, Albany NY, USAUwe Fuhr

– University Hospital of Cologne, Germany Ron Hines

– Medical College of Wisconsin, Milwaukee WI, USA

 Paul Hollenberg– University of Michigan, Ann Arbor MI, USA

 Magnus Ingelman-Sundberg – Karolinska Instutute, Stockholm, Sweden

 Tetsuya Kamataki

– Inst for Genome Function, Fujisawa, Japan Richard Kim

– Univ of Western Ontario, London, ON, Canada Steve Leeder

– Children's Mercy Hospital, Kansas City MO, USA

Peter Mackenzie – Flinders University, Adelaide, Australia

 Larry Marnett – Vanderbilt Univ, Nashville TN, USA

 Urs Meyer – Biozentrum, Univ of Basel, Basel, Switzerland

 Franz Oesch – Univ of Mainz, Mainz, Germany

B. Kevin Park - University of Liverpool, Liverpool, UKOlavi Pelkonen - University of Oulu, Oulu, FinlandLance Pohl - NIH/NHLBI, Bethesda, Maryland, USARory Remmel - University of Minnesota, Minneapolis, Minnesota, USAGlenn Sipes - University of Arizona, Tucson, Arizona, USABill Smith (President-Elect) - Pfizer Inc La Jolla Labs, San Diego, California, USASteve Tannenbaum - MIT, Cambridge, Massachusetts, USAKen Thummel - University of Washington, Washington, USAJacques Turgeon - Universite de Montreal, Montreal PQ, CanadaMike Waterman - Vanderbilt University, Nashville, Tennessee, USADavid Waxman - Boston University, Boston, Massachusetts, USAYasushi Yamazoe - Tohoku University, Sendai, JapanUli Zanger - Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany

Meeting Schedule – Overview

• 4-6 Short Courses• 3 Keynote Lectures• 2 Plenary Sessions• ISSX Awards and Award Lecture• 8-12 Symposia• 4-6 Industry-Sponsored Luncheon Seminars• 3 Days of Poster Viewing• 1 Poster Awards Session• 3 Days of Commercial Exhibits • ½ Day Free Time• Welcome Reception• ISSX Banquet

Meeting Schedule - Timetable

Sunday, September 29, 2013

12:00 - 18:00

Staff Prep

Monday, September 30, 2013

08:00 - 19:00 10:00 - 3:00 PM 09:00 - 12:00 12:00 - 14:00 14:00 - 17:00 18:00 - 18:15 18:15 – 19:00 19:00 – 21:00

Registration OpenISSX Council

Meeting

Short Course IShort Course II

Short Course III

Lunch for ShortCourse Attendees

Short Course IVShort Course V

Short Course VI

Opening Welcome Address

Keynote Lecture 1 Welcome Reception

Tuesday, October 1, 2013

08:00 - 17:00 09:00 – 11:00 11:00 – 11:30 11:30 – 12:30 12:30 – 14:00 14:00 – 16:00 16:00 – 16:30 16:30 – 18:30

Registration Open Plenary Session 1 Refreshment BreakISSX Awards and

Award Lecture

Lunch Industry Seminars

Poster ViewingExhibits

Symposium 1Symposium 2Symposium 3

Refreshment Break Poster Viewing

Symposium 4Symposium 5Symposium 6

Wednesday, October 2, 2013

08:00 - 17:00 09:00 – 11:00 11:00 – 11:30 11:30 - 12:30 12:30 - 14:00 14:00 – 19:00 19:00 - 22:00

Registration Open Plenary Session 2 Refreshment Break Keynote Lecture 2

Lunch Industry Seminars

Poster ViewingExhibits

Free Afternoon ISSX Banquet

Thursday, October 3, 2013

08:00 - 17:00 09:00 - 11:00 11:00 – 11:30 11:30 - 12:30 12:30 – 14:00 14:00 - 16:00 16:00 – 16:30 16:30

Registration OpenSymposium 7Symposium 8

Refreshment Break Keynote Lecture 3

Lunch Industry Seminars

Poster ViewingExhibits

Symposium 9Symposium 10

Poster Awards Closing

Keynote Lectures, Plenary Sessions, Symposia and Short Courses

Preliminary topics:• Role of inflammation in chemical carcinogenesis• Development and uses of stem cell derived hepatocyte-like cells and cultured

transformed cells• Utility and challenges of genome-wide association studies in pharmacogenetics

research• Extrapolation from in vitro and cell-based systems to predict in vivo human drug

metabolism• Extrapolation of animal drug disposition studies to humans• Utility of genetically modified animals in human drug disposition studies• Toxicogenomic profiling: current status and future utility in drug development• Drug-metabolizing enzymes as therapeutic targets• Receptor cross-talk in the regulation of drug metabolizing enzyme expression• Metabolomic profiling as a tool for identifying novel drug target interactions• Role of oxidative stress in cell physiology and pathology• Pharmacogenomics and translational medicine: promise and challenge• Effect of natural products on drug disposition• Methods for prediction of drug-drug interactions• Systems biology and xenobiotic-host interactions: concepts and technologies• Impact of advanced genome sequencing technologies on personalized medicine• Neuronal damage and neuroprotection against chemical insult• DNA damage and repair mechanisms in cancer risk• Cell type specific cytotoxic mechanisms• New approaches to the development of biomarkers for drug-induced toxicity

Projected Attendance

Members: 500

Non-members: 200

Students: 300

TOTAL 1000

Timeline

• Oct 2011– May 2012 (24-16 mo)• MOC/SAB memberships approved and finalized (1 mo)• MOC/SAB meetings/teleconferences/email circulars –

scientific program details finalized (7 mo)

• May 2012 (16 mo)• Finalized program, speakers and titles sent to SAC• SAC approval of program

• June – Oct 2012 (16-12 mo)• Speaker invitations• Identification/approval of satellite meetings

Toronto – The City

Toronto – Exploring the City

Shopping• Bloor Street• Yorkville• St. Lawrence Market• Eaton Centre• Distillery District

Arts & Culture• Art Gallery of Ontario• Royal Ontario Museum• Toronto Symphony• Live Theatre• Opera• Sports: MLB Playoffs?!

Neighbourhoods• Chinatown• Kensington Market• The Beaches• Little Italy• Queen Street West• Danforth/Greektown• Leaside• Roncesvalles Village• Bloor West Village

Walking/Cycling• Harbourfront• Discovery Walk tours• ‘City of Ravines’

10TH INTERNATIONAL ISSX MEETING

September 30 – October 3, 2013Westin Harbour Castle Hotel

Toronto, Canada