sd20410100 - EZ-RNA II Total RNA Isolation Kit with BCP

Kit components29.01.2018

Product code Description

20410100 EZ-RNA II Total RNA Isolation Kit with BCP, noChloroform

Components:20410A EZ-RNA II Sol.A Denaturing solution20410B EZ-RNA II Sol.B Water saturated phenol20410C EZ-RNA II Sol.C 1-Bromo-3-Chloropropanol solution

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Safety data sheetaccording to 1907/2006/EC, Article 31

Printing date 29.01.2018 Revision date: 29.01.2018

46.0.19

1 Identification of the substance/mixture and of the company/undertaking

· Product identifier

· Trade name: EZ-RNA II Sol.A

· Article number: 20410A· Relevant identified uses of the substance or mixture and uses advised against

No further relevant information available.· Application of the substance / the mixture

EZ-RNA II Total RNA Isolation Kit is a complete kit with ready-to-use reagents for the isolation of total RNAfrom samples of human, animal, plant, yeast, bacterial and viral origin. The kit contains BCP instead ofChloroform and is an improved version of the Chomczynski and Sacchi method (1),which is based ondisruption of cells in guanidine thiocyanate/detergent solution, followed by organic extraction and alcoholprecipitation of the RNA, and which allows simultaneous processing of a large number of samples.

· Details of the supplier of the safety data sheet· Manufacturer/Supplier:

Biological Industries Israel Beit Haemek Ltd.BEIT HAEMEK [email protected]

· Further information obtainable from: Product safety department.· Emergency telephone number: During normal opening times: +972/4/9962467

2 Hazards identification

· Classification of the substance or mixture· Classification according to Regulation (EC) No 1272/2008

d~ GHS07

Acute Tox. 4 H302 Harmful if swallowed.

· Label elements· Labelling according to Regulation (EC) No 1272/2008

The product is classified and labelled according to the CLP regulation.· Hazard pictograms

d~GHS07

· Signal word Warning

· Hazard-determining components of labelling:guanidinium thiocyanateammonium thiocyanate

· Hazard statementsH302 Harmful if swallowed.

· Precautionary statementsP101 If medical advice is needed, have product container or label at hand.P102 Keep out of reach of children.P103 Read label before use.P264 Wash thoroughly after handling.

(Contd. on page 2) GB

Version 1

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Trade name: EZ-RNA II Sol.A

(Contd. of page 1)

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P270 Do not eat, drink or smoke when using this product.P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.P330 Rinse mouth.P501 Dispose of contents/container in accordance with local/regional/national/international

regulations.· Additional information:

EUH032 Contact with acids liberates very toxic gas.· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.

3 Composition/information on ingredients

· Description: Mixture of substances listed below with nonhazardous additions.

· Dangerous components:

CAS: 593-84-0EINECS: 209-812-1

guanidinium thiocyanated~ Acute Tox. 4, H302; Acute Tox. 4, H312; Acute Tox. 4, H332

<25.0%

CAS: 1762-95-4EINECS: 217-175-6

ammonium thiocyanated~ Acute Tox. 4, H302; Acute Tox. 4, H312; Acute Tox. 4, H332

<8.0%

· Additional information: For the wording of the listed hazard phrases refer to section 16.

4 First aid measures

· Description of first aid measures· General information:

Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48hours after the accident.

· After inhalation:Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptomspersist.In case of unconsciousness place patient stably in side position for transportation.

· After skin contact: Generally the product does not irritate the skin.· After eye contact: Rinse opened eye for several minutes under running water.· After swallowing: Call for a doctor immediately.· Information for doctor:· Most important symptoms and effects, both acute and delayed No further relevant information available.· Indication of any immediate medical attention and special treatment needed

No further relevant information available.

5 Firefighting measures

· Extinguishing media· Suitable extinguishing agents: Use fire extinguishing methods suitable to surrounding conditions.· Special hazards arising from the substance or mixture No further relevant information available.


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(Contd. of page 2)

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· Advice for firefighters· Protective equipment: Mouth respiratory protective device.

6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures Mount respiratory protective device.· Environmental precautions: Do not allow to enter sewers/ surface or ground water.· Methods and material for containment and cleaning up:

No special measures required.Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.

· Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.

7 Handling and storage

· Handling:· Precautions for safe handling

Ensure good ventilation/exhaustion at the workplace.Prevent formation of aerosols.

· Information about fire - and explosion protection: No special measures required.

· Conditions for safe storage, including any incompatibilities· Storage:· Requirements to be met by storerooms and receptacles: 2 - 8 ℃· Information about storage in one common storage facility: Do not store together with acids.· Further information about storage conditions: Store in the dark.· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical facilities: No further data; see item 7.

· Control parameters

· Ingredients with limit values that require monitoring at the workplace:

1762-95-4 ammonium thiocyanate

WEL Long-term value: 5 mg/m³as CN; Sk

· Additional information: The lists valid during the making were used as basis.

· Exposure controls· Personal protective equipment:· General protective and hygienic measures:

Keep away from foodstuffs, beverages and feed.Wash hands before breaks and at the end of work.Avoid contact with the eyes and skin.


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(Contd. of page 3)

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· Respiratory protection:In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposureuse self-contained respiratory protective device.

· Protection of hands:

_S Protective gloves

The glove material has to be impermeable and ressistante to the product/substace/preperationDue to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradation

· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer. As the product is a preparation of several substances, theresistance of the glove material can not be calculated in advance and has therefore to be checked prior to theapplication.

· Penetration time of glove materialThe exact break through time has to be found out by the manufacturer of the protective gloves and has to beobserved.

· Eye protection: Not required.

9 Physical and chemical properties

· Information on basic physical and chemical properties· General Information· Appearance:

Form: FluidColour: According to product specification

· Odour: Characteristic· Odour threshold: Not determined.

· pH-value: Not applicable.

· Change in conditionMelting point/freezing point: Undetermined.Initial boiling point and boiling range: 100 °C

· Flash point: Not applicable.

· Flammability (solid, gas): Not applicable.

· Decomposition temperature: Not determined.

· Auto-ignition temperature: Product is not selfigniting.

· Explosive properties: Product does not present an explosion hazard.

· Explosion limits:Lower: Not determined.Upper: Not determined.

· Vapour pressure at 20 °C: 23 hPa


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(Contd. of page 4)

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· Density: Not determined.· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.

· Solubility in / Miscibility withwater: Fully miscible.

· Partition coefficient: n-octanol/water: Not determined.

· Viscosity:Dynamic: Not determined.Kinematic: Not determined.

· Solvent content:Water: >65.0 %VOC (EC) 0.00 %

Solids content:· Other information

<35.0 %No further relevant information available.

10 Stability and reactivity

· Reactivity No further relevant information available.· Chemical stability· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.· Possibility of hazardous reactions No dangerous reactions known.· Conditions to avoid No further relevant information available.· Incompatible materials: No further relevant information available.· Hazardous decomposition products: No dangerous decomposition products known.

11 Toxicological information

· Information on toxicological effects· Acute toxicity

Harmful if swallowed.· Primary irritant effect:· Skin corrosion/irritation Based on available data, the classification criteria are not met.· Serious eye damage/irritation Based on available data, the classification criteria are not met.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.

GB

(Contd. on page 6)

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12 Ecological information

· Toxicity· Aquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behaviour in environmental systems:· Bioaccumulative potential No further relevant information available.· Mobility in soil No further relevant information available.· Additional ecological information:· General notes:

Water hazard class 2 (German Regulation) (Self-assessment): hazardous for waterDo not allow product to reach ground water, water course or sewage system.Danger to drinking water if even small quantities leak into the ground.

· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· Other adverse effects No further relevant information available.

13 Disposal considerations

· Waste treatment methods· Recommendation

Must not be disposed together with household garbage. Do not allow product to reach sewage system.

· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.

14 Transport information

· UN-Number· ADR, IMDG, IATA UN2810

· UN proper shipping name· ADR 2810 TOXIC LIQUID, ORGANIC, N.O.S. (guanidinium

thiocyanate, ammonium thiocyanate)· IMDG, IATA TOXIC LIQUID, ORGANIC, N.O.S. (guanidinium

thiocyanate, ammonium thiocyanate)

· Transport hazard class(es)

· ADR, IMDG, IATA

dc̀k|· Class 6.1 Toxic substances.· Label 6.1

· Packing group· ADR, IMDG, IATA III


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(Contd. of page 6)

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· Environmental hazards: Not applicable.

· Special precautions for user Warning: Toxic substances.· Danger code (Kemler): 60· EMS Number: F-A,S-A· Stowage Category A · Stowage Code SW2 Clear of living quarters.

· Transport in bulk according to Annex II of Marpoland the IBC Code Not applicable.

· Transport/Additional information:

· ADR· Limited quantities (LQ) 5L· Excepted quantities (EQ) Code: E1

Maximum net quantity per inner packaging: 30 mlMaximum net quantity per outer packaging: 1000 ml

· Transport category 2 · Tunnel restriction code E

· IMDG· Limited quantities (LQ) 5L· Excepted quantities (EQ) Code: E1


· UN "Model Regulation": UN 2810 TOXIC LIQUID, ORGANIC, N.O.S.(GUANIDINIUM THIOCYANATE, AMMONIUMTHIOCYANATE), 6.1, III

15 Regulatory information

· Safety, health and environmental regulations/legislation specific for the substance or mixture

· Directive 2012/18/EU· Named dangerous substances - ANNEX I None of the ingredients is listed.· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 3, 65· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other informationThis information is based on our present knowledge. However, this shall not constitute a guarantee for anyspecific product features and shall not establish a legally valid contractual relationship.

· Relevant phrasesH302 Harmful if swallowed.H312 Harmful in contact with skin.H332 Harmful if inhaled.

· Department issuing SDS: Product safety department.· Contact: Ms. BADICHI GITLIN· Abbreviations and acronyms:

ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)


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(Contd. of page 7)

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IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)VOC: Volatile Organic Compounds (USA, EU)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 4: Acute toxicity – Category 4

GB

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· Trade name: EZ-RNA II Sol.B

· Article number: 20410B· Relevant identified uses of the substance or mixture and uses advised against








d~ GHS06 skull and crossbones

Acute Tox. 3 H311 Toxic in contact with skin.

Acute Tox. 3 H331 Toxic if inhaled.

d~ GHS08 health hazard

Muta. 2 H341 Suspected of causing genetic defects.

STOT RE 2 H373 May cause damage to organs through prolonged or repeated exposure.

d~ GHS05 corrosion

Skin Corr. 1B H314 Causes severe skin burns and eye damage.

Eye Dam. 1 H318 Causes serious eye damage.

d~ GHS07

Acute Tox. 4 H302 Harmful if swallowed.(Contd. on page 2)

GB

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Trade name: EZ-RNA II Sol.B

(Contd. of page 1)

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The product is classified and labelled according to the CLP regulation.· Hazard pictograms

d~GHS05

d~GHS06

d~GHS08

· Signal word Danger

· Hazard-determining components of labelling:phenol

· Hazard statementsH302 Harmful if swallowed.H311+H331 Toxic in contact with skin or if inhaled.H314 Causes severe skin burns and eye damage.H341 Suspected of causing genetic defects.H373 May cause damage to organs through prolonged or repeated exposure.

· Precautionary statementsP260 Do not breathe dusts or mists.P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with

water/shower.P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.P310 Immediately call a POISON CENTER/doctor.P405 Store locked up.P501 Dispose of contents/container in accordance with local/regional/national/international

regulations.· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.


· Chemical characterisation: Substances· CAS No. Description

108-95-2 phenol· Identification number(s)· EC number: 203-632-7· Index number: 604-001-00-2· Description: Mixture of substances listed below with nonhazardous additions.

· Dangerous components:

CAS: 108-95-2EINECS: 203-632-7

phenold~ Acute Tox. 3, H301; Acute Tox. 3, H311; Acute Tox. 3, H331; d~ Muta. 2,H341; STOT RE 2, H373; d~ Skin Corr. 1B, H314

>80.0%


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(Contd. of page 2)

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· Additional information: For the wording of the listed hazard phrases refer to section 16.



Immediately remove any clothing soiled by the product.Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48hours after the accident.Remove breathing equipment only after contaminated clothing have been completely removed.In case of irregular breathing or respiratory arrest provide artificial respiration.

· After inhalation:Supply fresh air or oxygen; call for doctor.In case of unconsciousness place patient stably in side position for transportation.

· After skin contact: Immediately wash with water and soap and rinse thoroughly.· After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor.· After swallowing:

Do not induce vomiting; call for medical help immediately.Drink plenty of water and provide fresh air. Call for a doctor immediately.

· Information for doctor:· Most important symptoms and effects, both acute and delayed No further relevant information available.· Indication of any immediate medical attention and special treatment needed



· Extinguishing media· Suitable extinguishing agents: Use fire extinguishing methods suitable to surrounding conditions.· Special hazards arising from the substance or mixture No further relevant information available.· Advice for firefighters· Protective equipment: Mouth respiratory protective device.


· Personal precautions, protective equipment and emergency proceduresWear protective equipment. Keep unprotected persons away.

· Environmental precautions:Not required.Do not allow to enter sewers/ surface or ground water.

· Methods and material for containment and cleaning up:No special measures required.Use neutralising agent.Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.

· Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.


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(Contd. of page 3)

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See Section 13 for disposal information.



Ensure good ventilation/exhaustion at the workplace.Open and handle receptacle with care.Prevent formation of aerosols.

· Information about fire - and explosion protection: Keep respiratory protective device available.

· Conditions for safe storage, including any incompatibilities· Storage:· Requirements to be met by storerooms and receptacles: 2 - 8 ℃· Information about storage in one common storage facility: Not required.· Further information about storage conditions: Store in the dark.· Specific end use(s) No further relevant information available.


· Additional information about design of technical facilities: No further data; see item 7.

· Control parameters

· Ingredients with limit values that require monitoring at the workplace:

108-95-2 phenol

WEL Short-term value: 16 mg/m³, 4 ppmLong-term value: 7.8 mg/m³, 2 ppmSk

· Additional information: The lists valid during the making were used as basis.


Keep away from foodstuffs, beverages and feed.Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.Store protective clothing separately.Avoid contact with the eyes and skin.






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(Contd. of page 4)

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· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer. As the product is a preparation of several substances, theresistance of the glove material can not be calculated in advance and has therefore to be checked prior to theapplication.


· Eye protection:

_R Tightly sealed goggles



Form: LiquidColour: Not determined.



· Change in conditionMelting point/freezing point: 40.8 °CInitial boiling point and boiling range: Undetermined.



· Ignition temperature: 595 °C


· Auto-ignition temperature: Product is not selfigniting.


· Explosion limits:Lower: 1.3 Vol %Upper: 9.5 Vol %

· Vapour pressure at 20 °C: 0.3 hPa

· Density: Not determined.· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.

· Solubility in / Miscibility withwater at 20 °C: 82 g/l


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(Contd. of page 5)

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· Solvent content:Organic solvents: >80.0 %Water: <10.0 %VOC (EC) >80.00 %

Solids content: 0.0 %· Other information No further relevant information available.





Harmful if swallowed.Toxic in contact with skin or if inhaled.

· LD/LC50 values relevant for classification:

108-95-2 phenol

Oral LD50 317 mg/kg (rat)

Dermal LD50 850 mg/kg (rabbit)

· Primary irritant effect:· Skin corrosion/irritation

Causes severe skin burns and eye damage.· Serious eye damage/irritation

Causes serious eye damage.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity

Suspected of causing genetic defects.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure

May cause damage to organs through prolonged or repeated exposure.(Contd. on page 7)

GB

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(Contd. of page 6)

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· Aspiration hazard Based on available data, the classification criteria are not met.



Water hazard class 2 (German Regulation) (Self-assessment): hazardous for waterDo not allow product to reach ground water, water course or sewage system.Must not reach sewage water or drainage ditch undiluted or unneutralised.Danger to drinking water if even small quantities leak into the ground.





· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.· Recommended cleansing agents: Water, if necessary together with cleansing agents.



· UN proper shipping name· ADR 2821 PHENOL SOLUTION· IMDG, IATA PHENOL SOLUTION


· ADR, IMDG, IATA



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(Contd. of page 7)

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· Environmental hazards:· Marine pollutant: No

· Special precautions for user Warning: Toxic substances.· Danger code (Kemler): 60· EMS Number: F-A,S-A· Stowage Category A








· UN "Model Regulation": UN 2821 PHENOL SOLUTION, 6.1, III



· Directive 2012/18/EU· Named dangerous substances - ANNEX I None of the ingredients is listed.· Seveso category H2 ACUTE TOXIC· Qualifying quantity (tonnes) for the application of lower-tier requirements 50 t· Qualifying quantity (tonnes) for the application of upper-tier requirements 200 t· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 3· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.


· Relevant phrasesH301 Toxic if swallowed.H311 Toxic in contact with skin.H314 Causes severe skin burns and eye damage.H331 Toxic if inhaled.


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(Contd. of page 8)

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H341 Suspected of causing genetic defects.H373 May cause damage to organs through prolonged or repeated exposure.


ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)VOC: Volatile Organic Compounds (USA, EU)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percentPBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 3: Acute toxicity – Category 3Acute Tox. 4: Acute toxicity – Category 4Skin Corr. 1B: Skin corrosion/irritation – Category 1BEye Dam. 1: Serious eye damage/eye irritation – Category 1Muta. 2: Germ cell mutagenicity – Category 2STOT RE 2: Specific target organ toxicity (repeated exposure) – Category 2

GB

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· Trade name: EZ-RNA II Sol.C

· Article number: 20410C· CAS Number:

109-70-6· EC number:

203-697-1· Relevant identified uses of the substance or mixture and uses advised against








d~ GHS06 skull and crossbones

Acute Tox. 3 H331 Toxic if inhaled.

d~ GHS07

Acute Tox. 4 H302 Harmful if swallowed.

Skin Irrit. 2 H315 Causes skin irritation.

Eye Irrit. 2 H319 Causes serious eye irritation.

STOT SE 3 H335 May cause respiratory irritation.


The substance is classified and labelled according to the CLP regulation.(Contd. on page 2)

GB

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Trade name: EZ-RNA II Sol.C

(Contd. of page 1)

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· Hazard pictograms

d~GHS06

· Signal word Danger

· Hazard-determining components of labelling:1-bromo-3-chloropropane

· Hazard statementsH302 Harmful if swallowed.H331 Toxic if inhaled.H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.

· Precautionary statementsP261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves / eye protection / face protection.P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.P321 Specific treatment (see on this label).P405 Store locked up.P501 Dispose of contents/container in accordance with local/regional/national/international

regulations.· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.


· Chemical characterisation: Substances· CAS No. Description

109-70-6 1-bromo-3-chloropropane· Identification number(s)· EC number: 203-697-1



Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48hours after the accident.

· After inhalation:Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptomspersist.In case of unconsciousness place patient stably in side position for transportation.

· After skin contact: Immediately wash with water and soap and rinse thoroughly.(Contd. on page 3)

GB

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(Contd. of page 2)

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· After eye contact:Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.

· After swallowing: Call for a doctor immediately.· Information for doctor:· Most important symptoms and effects, both acute and delayed No further relevant information available.· Indication of any immediate medical attention and special treatment needed



· Extinguishing media· Suitable extinguishing agents: Use fire extinguishing methods suitable to surrounding conditions.· Special hazards arising from the substance or mixture No further relevant information available.· Advice for firefighters· Protective equipment: Mouth respiratory protective device.


· Personal precautions, protective equipment and emergency procedures Not required.· Environmental precautions:

Not required.Do not allow to enter sewers/ surface or ground water.

· Methods and material for containment and cleaning up:No special measures required.Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.

· Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.



Ensure good ventilation/exhaustion at the workplace.Prevent formation of aerosols.

· Information about fire - and explosion protection: No special measures required.

· Conditions for safe storage, including any incompatibilities· Storage:· Requirements to be met by storerooms and receptacles: 2 - 8 ℃· Information about storage in one common storage facility: Not required.· Further information about storage conditions: Store in the dark.· Specific end use(s) No further relevant information available.


· Additional information about design of technical facilities: No further data; see item 7.(Contd. on page 4)

GB

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(Contd. of page 3)

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· Control parameters· Ingredients with limit values that require monitoring at the workplace: Not required.· Additional information: The lists valid during the making were used as basis.


Keep away from foodstuffs, beverages and feed.Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.Avoid contact with the eyes and skin.





· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer.


· Eye protection:

_R Tightly sealed goggles



Form: LiquidColour: Not determined.



· Change in conditionMelting point/freezing point: -58.87 °C


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(Contd. of page 4)

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Initial boiling point and boiling range: 142 °C




· Auto-ignition temperature: Not determined.


· Explosion limits:Lower: Not determined.Upper: Not determined.

· Vapour pressure at 20 °C: 7.5 hPa

· Density at 20 °C: 1.6 g/cm³· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.

· Solubility in / Miscibility withwater: Fully miscible.



· Solvent content:Organic solvents: 100.0 %VOC (EC) 99.99 %

Solids content: 0.0 %· Other information No further relevant information available.





Harmful if swallowed.Toxic if inhaled.


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· LD/LC50 values relevant for classification:

109-70-6 1-bromo-3-chloropropane

Oral LD50 930 mg/kg (rat)

Inhalative LC50/4 h 5.66 mg/l (rat)

· Primary irritant effect:· Skin corrosion/irritation

Causes skin irritation.· Serious eye damage/irritation

Causes serious eye irritation.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure

May cause respiratory irritation.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.



Water hazard class 3 (German Regulation) (Assessment by list): extremely hazardous for waterDo not allow product to reach ground water, water course or sewage system, even in small quantities.Danger to drinking water if even extremely small quantities leak into the ground.





· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.· Recommended cleansing agents: Water, if necessary together with cleansing agents.

GB

(Contd. on page 7)

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(Contd. of page 6)

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· UN proper shipping name· ADR 2688 1-BROMO-3-CHLOROPROPANE mixture· IMDG, IATA 1-BROMO-3-CHLOROPROPANE mixture


· ADR, IMDG, IATA



· Environmental hazards:· Marine pollutant: No

· Special precautions for user Warning: Toxic substances.· Danger code (Kemler): 60· EMS Number: F-A,S-A· Segregation groups Liquid halogenated hydrocarbons· Stowage Category A








· UN "Model Regulation": U N 2 6 8 8 1 - B R O M O - 3 - C H L O R O P R O P A N EMIXTURE, 6.1, III

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(Contd. on page 8)

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(Contd. of page 7)

46.0.19



· Directive 2012/18/EU· Named dangerous substances - ANNEX I Substance is not listed.· Seveso category H2 ACUTE TOXIC· Qualifying quantity (tonnes) for the application of lower-tier requirements 50 t· Qualifying quantity (tonnes) for the application of upper-tier requirements 200 t· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 3· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.



ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)VOC: Volatile Organic Compounds (USA, EU)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percentPBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 4: Acute toxicity – Category 4Acute Tox. 3: Acute toxicity – Category 3Skin Irrit. 2: Skin corrosion/irritation – Category 2Eye Irrit. 2: Serious eye damage/eye irritation – Category 2STOT SE 3: Specific target organ toxicity (single exposure) – Category 3

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