16 – 19 May

SCIENTIFIC PROGRAMME

24 CME Credits of the Swiss Society of Clinical Pharmacology and Toxicology

The 37th Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has been organised by the following Committees:

EAPCCT Scientific and Meetings Committee

EAPCCT Board

Congress secretariat

SOCIAL PROGRAMME

Welcome Reception (included in congress registration) at Volkshaus Basel on Wednesday 17 May 2017 at 19:00 hrs. The Volkshaus Basel is located about 10 minutes’ walk from the Congress Center Basel at Rebgasse 12-14, near Claraplatz. The new Volkshaus Basel, built in 1925, has been undergoing architectural intervention by renowned architects Herzog & de Meuron to revitalize the diversity of uses to combine cultural events, arts and gastronomy in one and the same building.

The Conference Dinner will be held in the historic guildhall (Zunftsaal) of the Restaurant Safranzunft located in the centre of the Old Town of Basel near Marktplatz, 15 minutes’ walk or 10 minutes by tram from the Congress Center at Gerbergasse 11 on Friday 19 May 2017 at 19:30 hrs (Swiss Francs 100). The noble Safran Guild originated in the middle ages as one of the main four merchant guilds, amongst a total of twenty guilds in Basel. Today Safran Guild is tasked with the care of maintaining the traditions it was built upon, and the continued nurture and growth of relationships within the community.

Tickets can be bought at the registration desk. Tickets are limited in number by the venue, so please book early to avoid disappointment.

Ana Ferrer Dufol, ChairMark Zammit, General SecretaryNicola Bates, Abstract EditorLisa Breitner, AdministratorRegis BedryPieter BrekelmansMiran Brvar

Alexander Campbell Paul DarganMichael EddlestonFlorian EyerLotte HoegbergKnut Erik HovdaDavide Lonati

Charles McKayBruno Megarbane Robert Palmer Steven Seifert Horst Thiermann Martin Wilks Sergey Zakharov

Bruno Megarbane, PresidentAlexander Campbell, Past-PresidentMartin Wilks, President-ElectMark Zammit, General SecretarySergey Zakharov, Treasurer

Pieter Brekelmans Miran BrvarPatricia CaseyPaul DarganAna Ferrer Dufol

Lotte Hoegberg Peter Hulten Davide Lonati Horst Thiermann Geert Verstegen

Maria Cubí, 4 Pral08006 Barcelona – Spaineapcct2017@pacifico-meetings.com

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Room Montreal, Tuesday 16 May 2017

Toxicological analysis and contribution to diagnosis and patient management in clinical toxicology

Session chair: Bruno Mégarbane, Miran Brvar

09:00 - 09:30 Chromatographic techniques – applications for ethanol and toxic alcohol poisoning Ana Ferrer Dufol, Clinical University Hospital, Zaragoza, Spain09:30 - 10:00 Mass spectrometry – applications and future development Olivier Laprévote, Universite Paris Descartes, AP-HP, Paris, France10:00 - 10:30 Development of library search-based screening system Hans Maurer, Saarland University, Homburg (Saar), Germany10:30 - 11:00 Coffee

Session chair: Alex Manini, Carlo Locatelli

11:00 - 11:30 Tox analysis for new psychoactive substance screening in biological matrices: where do we stand today? Markus R Meyer, Saarland University, Homburg (Saar), Germany11:30 - 12:00 Metal detection assays for exposure diagnosis and monitoring Souleiman EL Balkhi, Centre Hospitalier Universitaire de Limoges, Limoges, France12:00 - 12:30 Tox analysis for risk assessment: methodological requirements Michael G Holland, SUNY Upstate Medical University, Syracuse, USA12:30 – 13:30 Lunch

Session chair: Charles McKay, Daniela Pelclova

13:30 - 14:00 Tox analyses for substances of abuse and psychotropic drugs in the emergency room (ER) Matthias Liechti, University Hospital Basel, Switzerland14:30 – 15:00 Usefulness of toxicological analysis for the management of cardiotoxicant poisonings Bruno Mégarbane, Paris-Diderot University, Lariboisière Hospital, Paris, France15:00 – 15:30 TOXI-triage - can pesticide and toxic alcohol exposure be diagnosed by breathalyzer Michael Eddleston, University of Edinburgh, UK15:30 – 16:00 Coffee

Session chair: Horst Thiermann, Alexander Campbell

16:00 – 16:30 Forensic toxicology - how to combine selectivity, sensitivity, and robustness Stephen Morley, University of Leicester Hospital Trust, Leicester, UK16:30 - 17:00 Hair analysis: when, how and why? Pascal Kintz, X-Pertise Consulting, Strasbourg, France17:00 – 17:30 Postmortem tox analysis: principles and interpretation Thomas Kraemer, University of Zurich, Switzerland17:30 – 18:00 Biomedical verification of chemical warfare agent exposure Harald John, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany

PRE-CONGRESS SYMPOSIUM

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Room Montreal, Wednesday 17 May 2017 (morning)

Plenary Lecture followed by Toxicology of Migration & Short Orals (1)

Session chair: Alexander Campbell, Ana Ferrer Dufol

08:55 – 09:00 Welcome and opening Bruno Mégarbane, President EAPCCT09:00 – 09:45 Public health aspects of the migrant crisis and the role of WHO Joanna Tempowski, World Health Organization, Geneva, Switzerland09:50 – 10:10 Rapid Risk Assessment of chemical/toxicological incidents with cross-border threats to public health Raquel Duarte Davidson, Public Health England, Chilton, UK10:10 – 10:30 Incidents related to illegal importation of chemicals in the US Michael Holland, SUNY Upstate Medical University Syracuse, USA 10:30 – 11:10 Coffee and electronic posters

Session chair: Alvin Bronstein, Viorela Nitescu

11:10 – 11:30 Specific poisonings risks for migrants or caused by migrating poisons in Germany Herbert Desel, Kathrin Begemann and Esther Feistkorn11:30 Poisonings involving refugees in Northern Germany during the migrant crisis, 2015- 2016 (abstract no. 7) Rafael Wagner (Göttingen)11:35 Exposures in refugees reported to the Poisons Information Centre Erfurt, 2007-2016 (abstract no. 8) Michael Deters (Erfurt)11:40 Two cases of ayahuasca poisoning: a poison crossing borders (abstract no. 9) Mari A Bjornaas (Oslo)11:45 Most amatoxin poisonings in Sweden occur in persons of non-Swedish background (abstract no. 10) Erik Lindeman (Stockholm)11:50 Unusual mushroom poisoning in an immigrant: a case report (abstract no. 11) Nena Golob (Ljubljana)11:55 Increased migration to Sweden and increased incidence of isoniazid poisonings (abstract no. 12) Lisa Franzen (Stockholm)12:00 Drugs crossing borders: unexpected dosing error with identical formulation of prazepam (Lysanxia®) (abstract no. 13) Jonas Moens (Brussels)12:05 Occupational inhalation poisoning with the veterinary antibiotic tiamulin (abstract no. 14) Mojca Dobaja (Ljubljana)12:10 Occupational-related fatal case of acute methyl ethyl ketone peroxide ingestion: case report and review of the literature (abstract no. 15) Te-Hao Wang (Taipei)

MAIN CONGRESS

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MAIN CONGRESS

Room Singapore, Wednesday 17 May 2017 (morning)

Antidotes: Something Old, Something New, Something Borrowed, Something Blue

Session chair: Martin Wilks, Christopher Yates

09:50 – 10:10 New antidotal strategies for nerve agent poisoning Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany10:10 – 10:30 Use of pre-hospital ethanol administration to improve outcome in methanol mass poisoning outbreaks: the Czech experience. Sergey Zakharov, General University Hospital, Charles University, Prague, Czech Republic10:30 – 11:10 Coffee and electronic posters

Session chair: Richard Dart, Carlo Locatelli

11:10 – 11:30 Optimising the use of DMSA/succimer in lead poisoning Sally Bradberry, National Poisons Information Service (Birmingham Unit), Birmingham, UK11:30 – 11:50 Challenges in methylene blue therapy Robert Hoffman, NYU School of Medicine, New York, USA11:50 – 12:05 Acute digoxin overdose and response to antibody (DORA study) (abstract no. 18) Betty SH Chan (Sydney)12:05 – 12:20 Prevention of lethal colchicine toxicity by colchicine-specific Fab treatment in a porcine model (abstract no. 19) Michael Eddleston (Edinburgh) 12:20 – 12:30 General discussion12:30 – 14:00 Lunch and posters

12:15 Suspected metal fume fever from domestic exposure to lead fumes while making lead sinkers in an enclosed space (abstract no. 16) Andis Graudins (Dandenong) 12:20 Descriptive study of an urban academic toxicology consultation service, 2012-2016 (abstract no. 17) David Goldberger (Philadelphia)12:25 - 12:30 General discussion 12:30 - 14:00 Lunch and posters

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MAIN CONGRESS

Room Montreal, Wednesday 17 May 2017 (afternoon)

Controversies in Pesticide Toxicology including Pro/Con Debate

Session chair: Michael Eddleston, Allister Vale

14:00 – 14:20 Neonicotinoid insecticides - safe for humans? Allister Vale, National Poisons Information Service (Birmingham Unit), Birmingham, UK14:20 – 14:40 Do neurobehavioral changes occur in humans as long-lasting consequences of acute poisoning with organophosphorus insecticides? Marcello Lotti, University of Padua, Padova, Italy14:40 – 15:00 Pesticides and Parkinson's disease: is there a causal link? Martin Wilks, Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland15:00 – 15:45 Debate: Is glyphosate a probable human carcinogen? Chris Portier, Independent Consultant, Thun, Switzerland Danièle Court Marques, European Food Safety Authority (EFSA), Parma, Italy15:45 – 16:15 Coffee and electronic posters

Room Singapore, Wednesday 17 May 2017 (afternoon)

Antidotes: Something Old, Something New, Something Borrowed, Something Blue (cont)

Session chair: Irma de Vries, Horst Thiermann

14:00 – 14:15 Acute hypersensitivity reaction to Crotalidae polyvalent immune Fab (CroFab) initially presenting as galactose-alpha-1,3-galactose (alpha-gal) allergy (abstract no. 20) Justin Rizer (Charlottesville) 14:15 – 14:30 Infant botulism in Italy: antidote treatment consideration from 8 years’ experience (abstract no. 21) Davide Lonati (Pavia)14:30 – 14:45 Vipera ammodytes bites treated with antivenoms Viperfav® and ViperaTAb® (abstract no. 22) Miran Brvar (Ljubljana)14:45 – 15:00 Discontinuation of N-acetylcysteine in patients meeting certain criteria: outcomes in a retrospective review (abstract no. 23) Christopher Hoyte (Aurora)15:00 – 15:15 Fewer adverse effects with a modified 2-bag intravenous acetylcysteine protocol compared to the traditional 3-bag protocol in paracetamol overdose (abstract no. 24) Richard McNulty (Sydney)15:15 – 15:30 Palatability of tablets and capsule forms of N-acetylcysteine and methionine and associated adverse events in healthy volunteers (abstract no. 25) Vindya M Pathiraja (Peradeniya)15:30 – 15:45 Efficacy of isosorbide dinitrate as an antidote in cyanide poisoning in a swine model (abstract no. 26) Ophir Lavon (Haifa)15:45 – 16:15 Coffee and electronic posters

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MAIN CONGRESS

Room Montreal, Wednesday 17 May 2017 (afternoon)

Oral Session: Epidemiology of Poisoning

Session chair: John Thompson, Bill Banner

16:15 – 16:30 Dramatic improvement of poisoned patient survival in Southern province, Sri Lanka (abstract no. 31) Kasun M Fernando (Ambalangoda)16:30 – 16:45 Patients with acute chemical exposure seen in Emergency Departments (ED) in Spain: results of the Spanish Toxic Surveillance System (STSS) 2015 (abstract no. 32) Ana Ferrer Dufol (Zaragoza) 16:45 – 17:00 Increases in pediatric vitamin D exposure calls to the US National Poison Data System (abstract no. 33) Kevin C Osterhoudt (Philadelphia)

Room Singapore, Wednesday 17 May 2017 (afternoon)

Oral Session: Poisoning Outbreaks

Session chair: Joanna Tempowski, Sergey Zakharov

16:15 – 16:30 Elimination half-life and chronic health impairment 50 years after 2, 3, 7, 8-tetra chloro-dibenzo- p- Dioxin (TCDD) exposure (abstract no. 34) Daniela Pelclova (Prague)16:30 – 16:45 National vitamin D intoxication outbreak among infants due to a manufacturing error of vitamin D droplets: challenges for the health care system (abstract no. 35) Søren Bøgevig (Copenhagen) 16:45 – 17:00 Dosage regimen of biperiden to treat haloperidol-induced severe facio-troncular dystonic syndrome in children (abstract no. 36) Frederic J Baud (Paris)

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MAIN CONGRESS

Room Montreal, Thursday 18 May 2017 (morning)

Louis Roche Lecture followed by Pro/Con Debate & Paracetamol Poisoning: New Insights

Session chair: Bruno Mégarbane

08:45 – 09:00 Introduction and presentation of Louise Roche lecturer09:00 – 09:45 New psychoactive substances: a challenge and impulse for clinical toxicology Carlo Locatelli, Poison Control Centre, IRCCS Maugeri Foundation Hospital, Pavia, Italy

Session chair: Sally Bradberry, Patricia Casey

09:45 – 10:30 Debate: Shorter course IV acetylcysteine for paracetamol poisoning – it’s time to make a SNAP decision James Dear, University of Edinburgh, UK Richard C Dart, Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, USA10:30 – 11:10 Coffee and electronic posters

Session chair: Paul Dargan, D Nicholas Bateman

11:10 – 11:30 Biomarkers for paracetamol poisoning - research tools or practical aids to the management of the poisoned patient? Nicholas A Buckley, University of Sydney, Australia11:30 – 11:45 Modified release paracetamol overdose: a prospective observational study (abstract no. 111) Angela L Chiew (Randwick) 11:45 – 12:00 Analysis of an abbreviated acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol (abstract no. 112) Anselm Wong (Victoria) 12:00 – 12:15 Review of the availability of paracetamol sold as over-the-counter drugs in European pharmacies; a descriptive cross sectional study (abstract no. 113) Britt Morthorst (Copenhagen)12:15 – 12:30 Evaluation of a US Food and Drug Administration mandate to limit acetaminophen in prescription combination products (abstract no. 114) David Goldberger (Philadelphia)12:30 – 14:00 Lunch and posters

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MAIN CONGRESS

Room Singapore, Thursday 18 May 2017 (morning)

Toxicology of Anti-Convulsant Drugs Followed by Short Orals (2)

Session chair: Herbert Desel, Alison Good

09:50 – 10:10 Mitochondrial toxicity of antiepileptic drugs and implications for the treatment of mitochondrial epilepsy Josef Finsterer, Municipality of Vienna, Austria10:10 – 10:30 Are new anticonvulsant drugs safer than old ones? Bruno Mégarbane, Paris-Diderot University, Paris, France10:30 – 11:10 Coffee and electronic posters

Session chair: Mark Zammit, Kim Dalhoff

11:10 – 11:30 How to manage poisoning with anticonvulsants Florian Eyer, Klinikum rechts der Isar, Technical University of Munich, Germany11:30 – 11:50 Too much of a good thing: Antiepileptic toxicity Sophie Gosselin, McGill University Health Centre, Montreal, Canada11:50 A characterization of levetiracetam abuse and misuse reported to US Poison Centers through the National Poison Data System (NPDS) (abstract no. 115) Christopher Hoyte (Denver)11:55 Acute lamotrigine overdoses treated at the department of Emergency and Clinical Toxicology during a 3-year period clinical overview (abstract no. 116) Gordana Vuković-Ercegović (Belgrade) 12:00 Clinical features of acute carbamazepine poisoning in children: a 5-year retrospective study (abstract no. 117) Viorela Nitescu (Bucharest)12:05 Severe toxicity following lamotrigine overdose: a review of calls to Australia’s largest Poisons Information Centre (abstract no. 118) Rose Cairns (Sydney) 12:10 Severe valproic acid poisoning associated with atrial fibrillation and extreme high serum concentrations (abstract no. 119) Csaba Pap (Budapest)12:15 Lamotrigine enquiries to the Austrian Poisons Information Centre: a retrospective 14 year study (abstract no. 120) Tara Arif (Vienna)12:20 Exposures to valproic acid: a 14 year descriptive study of Austrian Poisons Information Centre data (abstract no. 121) Tara Arif (Vienna)12:25 – 12:30 General discussion12:30 – 14:00 Lunch and posters

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MAIN CONGRESS

Room Montreal, Thursday 18 May 2017 (afternoon)

The Virtual Toxicologist: Leveraging Social Media for Toxicology Education, Outreach & Research followed by Short Oral Presentations Social Media

Session chair: Peter Chai, Davide Lonati

13:55 – 14:00 Introduction to the Mini Symposium/Introduction to Social Media Platforms Peter R Chai, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA14:00 – 14:15 Social media in toxicologic disasters Timothy B Erickson, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA14:15 – 14:30 Social Media for online education Anselm Wong, Austin Health, Melbourne, Australia14:30 – 14:45 Twitter and Facebook groups: How we can maximize our toxicology education and engage learners Matthew Griswold, University of Massachusetts Medical School, Worcester, USA Mark Neavyn, University of Massachusetts Medical School, Worcester, USA14:45 – 15:00 The National Poisons Information Centre experience in social media for outreach Niamh English, National Poisons Information Centre Ireland, Dublin, Ireland15:00 – 15:15 The Edinburgh Clinical Toxicology experience in social media Euan Sandilands, National Poisons Information Centre Edinburgh, Edinburgh, UK15:15 – 15:30 Research in drug trends, substances of abuse and self-harm on social media Edward W Boyer, Harvard Medical School, Boston, USA Alex Manini, Icahn School of Medicine at Mount Sinai, New York, USA15:30 Please “like” us: Facebook as an outreach tool for a poisons information centre (abstract no. 129) Niamh Walsh (Dublin)15:35 Linguistic differences between Spanish and English tweets that mention opioids (abstract no. 130) Alex F Manini (New York)15:40 YouTube™ is a feasible tool to disseminate educational toxicology videoconferences: The Global Educational Toxicology Uniting Project (GETUP) (abstract no. 131) Anselm Wong (Victoria) 15:45 – 16:15 Coffee and electronic posters

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MAIN CONGRESS

Room Singapore, Thursday 18 May 2017 (afternoon)

Experimental and Applied ResearchToxicosurveillance (including Poison Centre Activities)

Session chair: Florian Eyer, Sophie Gosselin

14:00 Comparative extractive efficiency of continuous veno-venous hemodiafiltration (CVVHDF) and molecular adsorbent recirculating system (MARS) in simulated verapamil poisoning: an ex vivo study (abstract no. 122) Frederic J Baud (Paris)14:15 Leukotriene-mediated neuroinflammation and toxic brain damage in methanol poisoning (abstract no. 123) Sergey Zakharov (Prague) 14:30 Transient receptor potential (TRP) channels as therapeutic targets in toxic lung injury (abstract no. 124) Dirk Steinritz (Munich)14:45 Pharmacogenetics of 3,4-methylenedioxymethamphetamine (MDMA): cytochrome P450 polymorphisms moderate pharmacokinetics and pharmacodynamic effects of MDMA in healthy subjects (abstract no. 125) Patrick Vizeli (Basel) 15:00 Age of misuse exposures reported by the Global Toxicosurveillance Network (GTNet) (abstract no. 126) Laura J Fischer (Denver) 15:15 Using Swedish Poisons Information Centre data to identify chemical accident hazards at the workplace (abstract no. 127) Anita Annas (Stockholm) 15:30 Utilisation of desferrioxamine in iron poisoning: experience of the UK National Poisons Information Service (NPIS) 2014-2016 (abstract no. 128) D Nicholas Bateman (Edinburgh)15:45 – 16:15 Coffee and electronic posters

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MAIN CONGRESS

Room Montreal, Thursday 18 May 2017 (afternoon)

The Virtual Toxicologist: Leveraging Social Media for Toxicology Education, Outreach & Research

Session chair: Hugo Kupferschmidt, Peter Hultén

16:15 – 16:45 Round Table on Social Media Mark Neavyn, UMass Memorial Center, Worcester, USA (moderator) Katharine Boyle, Beth Israel Deaconess Medical Center, Boston, USA Peter R Chai, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA Niamh English, National Poisons Information Centre Ireland, Dublin, Ireland Timothy Erickson, Brigham and Women’s Hospital, Boston, USA Euan Sandilands, National Poisons Information Centre Edinburgh, UK

17:00 – 18:30 EAPCCT General Assembly

Room Singapore, Thursday 18 May 2017 (afternoon)

Novel Psychoactive Substances

Session chair: Edward Krenzelok, David Wood

16:15 – 16:30 Toxicity associated with the use of α-PVP (α-pyrrolidinovalerophenone): a case series of 417 patients presenting to a regional poisons treatment centre (abstract no. 136) David M Wood (London)16:30 – 16:45 Severe cardiovascular toxicity, cerebral hemorrhage and mortality after using 4-fluoroamphetamine (4-FA) (abstract no. 137) Johanna J. Nugteren-van Lonkhuyzen (Utrecht)16:45 – 17:00 Rhabdomyolysis induced by psychoactive substances: an analysis of EuroDEN data (abstract no. 138) Piotr M Kabata (Gdańsk)

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MAIN CONGRESS

Room Montreal, Friday 19 May 2017 (morning)

Young Investigator Award (YIA)

Session chair: Robert Palmer, Simon Thomas

08:45 – 08:50 Introduction08:50 – 09:05 Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (abstract no. 220) Daniel J Antoine (Liverpool)09:05 – 09:20 Ciguatoxin-induced chronic disease unmasks people carrying human leukocyte antigen (HLA) epitopes peculiar to celiac disease and rheumatoid arthritis (abstract no. 221) Azzurra Schicchi (Pavia)09:20 – 09:35 Imaging drug-drug interaction using positron emission tomography (PET) scans: investigating the impact of diazepam on buprenorphine-induced respiratory depression (abstract no. 222) Dominique Vodovar (Paris) 09:35 – 09:50 Utility of QT interval corrected by the Rautaharju method to predict drug-induced torsades de pointes (abstract no. 223) Rittirak Othong (Bangkok)09:50 Judging commences09:50 – 10:05 Lucy in the Sky with Diamonds or LSD: Past, Present and Future Matthias Liechti, University Hospital Basel, Switzerland10:05 – 10:20 Paracelsus in Basel Martin Wilks, Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland10:20 – 10:30 Presentation to the winner of the YIA10:30 – 11:10 Coffee and electronic posters

Biomarkers, Clinical Toxicology and Translational Medicine (APAMT Symposium at EAPCCT)

Session chair: Jou-Fang Deng, Charles McKay

11:10 – 11:30 Regulatory toxicology: are biomarkers the missing link? Darren Roberts, St Vincent's Hospital, Sydney, Australia and Medical School, Australian National University, Canberra, Australia11:30 – 11:50 Use of biomarkers in laboratory-models of toxicity Klintean Wunnapuk, Chiang Mai University, Chiang Mai, Thailand 11:50 – 12:10 Biomarkers of kidney injury: clinical research generates both questions and answers Fahim Mohammed, SACTRC, University of Peradeniya, Sri Lanka12:10 – 12:30 Biomarkers in snake envenomation: local data prompts broad applications Anjana Silva, Monash Venom Group, Monash University, Clayton, Australia and Rajarata University of Sri Lanka, Saliyapura, Sri Lanka12:30 – 14:00 Lunch and posters

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MAIN CONGRESS

Room Singapore, Friday 19 May 2017 (morning)

Short Orals (3) & Education and Outreach

Session chair: Nicolas Buckley, Thomas Zilker

11:10 QT prolongation in opioid poisoning is mostly due to methadone (abstract no. 230) Gopi Mann (Sydney)11:15 Comparison of self-reported recreational substance use with immunoassay and liquid chromatography mass spectrometry findings in cases with acute recreational drug toxicity (abstract no. 231) Evangelia Liakoni (Basel)11:20 Prognostic utility of initial lactate for Emergency Department (ED) drug overdose fatality: a validation cohort (abstract no. 232) Alex F Manini (New York) 11:25 Does targeted temperature management improve hospital survival for presumed drug overdose-related cardiac arrest? (abstract no. 233) Alex F Manini (New York)11:30 Pharmacokinetics and pharmacodynamics of two doses of oral LSD in healthy subjects (abstract no. 234) Matthias E Liechti (Basel)11:35 Relationship between poison center opioid exposure data and mortality rates and National Vital Statistics System mortality rates (abstract no. 235) Janetta L Iwanicki (Denver)11:40 Tramadol poisoning in the intensive care unit: clinical presentation and prognostic value of plasma tramadol concentration on admission (abstract no. 236) Bruno Megarbane (París)11:45 Pack size restriction of mild analgesics sold as over-the-counter drugs in pharmacies in Denmark: preliminary register findings (abstract no. 237) Britt Morthorst (Copenhagen) 11:50 Seasonality in intentional drug intake by adolescents (abstract no. 238) Arjen Koppen (Utrecht)11:55 Caustic ingestion in children: experience of a Pediatric Emergency Department in Rome (abstract no. 239) Francesco P Rossi (Roma) 12:00 Drug-facilitated crimes (DFC): four years of admission in a French emergency medico- legal center specializing in victims of assaults (abstract no. 240) Emilie Christin (Bordeaux)12:05 Severe poisonings and their outcomes reported to the National Poisons Information Service (NPIS), 2008-2015 (abstract no. 241) John P Thompson (Cardiff)12:10 Emergency Department presentations with illicit drugs associated with problematic drug use (iPDU) toxicity are not commonly associated with co-use of new psychoactive substances (NPS) (abstract no. 242) Luke C De La Rue (London)12:15-12:30 Impact of online toxicology training on health professionals: the Global Educational oxicology Uniting Project (GETUP) (abstract no. 243) Anselm Wong (Victoria)12:30–14:00 Lunch and posters

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MAIN CONGRESS

Room Montreal, Friday 19 May 2017 (afternoon)

Pre-hospital Management of Poisonings

Session chair: Miran Brvar, Dabor Résière

14:00 – 14:20 In the urban area of a developed country: the Oslo experience Odd Martin Vallersnes, Oslo Accident and Emergency Outpatient Clinic, Oslo, Norway14:20 – 14:40 In the rural area of a developing country: the Bangladesh experience Fazle Rabbi Chowdhury, Nuffield Department of Medicine, University of Oxford, UK14:40 – 15:00 On the way to hospital with the paramedics: the US experience Alex Manini, The Icahn School of Medicine at Mount Sinai, New York, USA15:00 – 15:20 On the scene by a physician-manned emergency medical service: the French SAMU experience Vincent Danel, Centre Hospitalier Universitaire, Grenoble, France15:20 – 15:40 With long-distance transport: the Australian experience Shaun Greene, Victorian Poisons Information Centre, Austin Toxicology Service, Melbourne, Australia15:40 – 15:45 General discussion15:45 – 16:15 Coffee and electronic posters

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MAIN CONGRESS

Room Singapore, Friday 19 May 2017 (afternoon)

Education and Outreach (cont)Best Paper SessionSpecial Session

Session chair: Régis Bédry, Geert Verstegen

14:00 – 14:20 Sliding drugs: a co-production by a Poison Centre and School of Cinema for preventing NPS use by teenagers (abstract no. 244) Carlo A Locatelli (Pavia)

14:20 – 15:20 Best Paper sessionAn international panel have each been asked to select a clinical toxicology paper published in 2016 that they consider to be among the best. The aim is to highlight papers that have changed or challenged clinical practice, taught something new or unexpected, improved understanding of toxicological mechanisms, or inspired the panellists. The speakers will defend their choice in a brief 10 minute presentation followed by discussion.

Discussants: Nicholas A Buckley

Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteineDavid G. Cairney, Hannah K. S. Beckwith, Khalid Al-Hourani, Michael Eddleston, D. Nicholas Bateman & James W. Dear Clinical Toxicology (2016): 54:5, 405-410.

Robert PalmerInterpretation of postmortem vitreous concentrations of sodium and chlorideB. Zilg, K. Alkass, S. Berg, H. Druid Forensic Science International 2016: 263:107–113.

Mark ZammitHealthcare professionals are less confident in managing acute toxicity related to the use of new psychoactive substances (NPS) compared with classical recreational drugs. Wood DM, Ceronie B, Dargan PIQJM 2016: 109(8):527-9.

15:20 – 15:40 Special session Polonium-210 poisoning: a first-hand account Paul Dargan, Guy's and St Thomas' NHS Foundation Trust, London, UK

15:45 – 16:15 Coffee and electronic posters

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MAIN CONGRESS

Room Montreal, Friday 19 May 2017 (afternoon)

Pre-hospital Management of Poisonings (cont)

Session chair: Nicola Bates, Frederic Baud

16:15 – 16:30 Reductions in emergency department referrals from primary care after use of the UK National Poisons Information Service (abstract no. 249) Muhammad EMO Elamin (Newcastle upon Tyne)16:30 – 16:45 Venlafaxine poisoning in the intensive care unit: clinical presentation and role of the cytochrome P450 2D6 phenotype in the onset of cardiovascular complications (abstract no. 250) Bruno Megarbane (Paris) 16:45 – 17:00 Baclofen poisoning in the intensive care unit: clinical features and investigation of the relationships between toxic encephalopathy and the plasma baclofen concentration (abstract no. 251) Bruno Megarbane (Paris)

Room Singapore, Friday 19 May 2017 (afternoon)

Natural Toxins

Session chair: Andis Graudins, Emilio Salgado

16:15 – 16:30 Myanmar Snakebite Project: analysis of the first 627 prospective cases (abstract no. 252) Julian White (North Adelaide)16:30 – 16:45 Mushroom poisonings in the Slovak Republic: a 20-year retrospective analysis (abstract no. 253) Silvia Plackova (Bratislava)16:45 – 17:00 Molecular and toxicological study of Italian Viper venom neurotoxicity (abstract no. 254) Marco Pirazzini (Padova)

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ELECTRONIC POSTERS

Wednesday 17 May 2017 (morning)Session chair: Davide Lonati 10:30 – 11:10 1. Deltamethrin poisoning in two children following treatment of head lice with a veterinary product (abstract no. 1)

Yury N Ostapenko (Moscow) 2. Polyneuropathy following fenitrothion poisoning (abstract no. 2)

Kyoung Ho Choi (Seoul)3. Deltamethrin acute poisoning by intravenous injection (abstract no. 3)

Ana Ferrer Dufol (Zaragoza)4. Toxicity indicator value of plasma pseudocholinesterase in hepatic patients (abstract no. 4)

Fawaz Al-Mousa (Riyadah)5. Delayed and fatal toxicity of chlorfenapyr (abstract no. 6)

Chun-Chi Lin (I-Lan)

Wednesday 17 May 2017 (afternoon)Session chair: Ana Ferrer Dufol

15:45 – 16:15 1. Risk factors for mortality after caustic ingestion (abstract no. 27)

Blažena Cagáňová (Bratislava)2. Soap bars oral poisoning: are patients with dementia at risk? (abstract no. 29)

Marion Brunet (Angers) 3. Unusual administration route of an antiparasitic product: a case report (abstract no. 30)

Radu C Tincu (Bucharest)

Thursday 18 May 2017 (morning)Session chair: Christopher Yates

10:30 – 11:10 1. Life-threatening 3, 4-methylenedioxy-methamphetamine (MDMA) poisoning: clinical features and prognostic

value of MDMA and its major metabolite concentrations on admission (abstract no. 105) Bruno Megarbane (Paris)

2. Cathinones, and in particular mephedrone, remain the biggest novel psychoactive substance (NPS) associated with acute harm and Emergency Department presentations in Europe (abstract no. 106)David M Wood (London)

3. Emergence of fentanyls on the Swedish novel psychoactive substance market: analytically confirmed intoxications from the STRIDA project (abstract no. 107) Matilda Bäckberg (Stockholm)

4. Synthetic cannabinoid receptors agonists (SCRA) toxicity associated with reduced level of consciousness: an analytically confirmed case series (abstract no. 108) Paul I Dargan (London)

5. Trends in the surveillance of mephedrone, MDMA and cocaine detected in anonymous pooled street urine samples: is mephedrone use decreasing in the UK? (abstract no. 109)John RH Archer (London)

6. Marijuana and synthetic cannabinoid patterns in a US state with legalized marijuana: a 5-year NPDS review (abstract no. 110) Shireen Banerji (Denver)

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ELECTRONIC POSTERS

Thursday 18 May 2017 (afternoon)Session chair: Peter Hultén

15:45 – 16:15 1. Analytically confirmed post-injection delirium/sedation syndrome (PDSS) after olanzapine long-acting

injection (abstract no. 132) Valeria M Petrolini (Pavia)

2. Incidence and risk factors for hyperlactatemia in patients with metformin overdose (abstract no. 133) Emily S Taub (New York)

3. Paracetamol-protein adducts following modified release paracetamol overdose (abstract no. 134) Angela L Chiew (Sydney)

4. Survival after varenicline and phentermine overdose with documented serum blood concentrations (abstract no. 135) Andis Graudins (Victoria)

Friday 19 May 2017 (morning)Session chair: Paul Dargan

10:30 – 11:10 1. The role of expert identification of spiders in the correct management of spider bites: a pilot study from

Pavia Poison Control Centre (abstract no. 224) Carlo A Locatelli (Pavia)

2. Spider bite: a rare case of cutaneous loxoscelism in the west of Iran (abstract no. 225) Ahmad Ghoochani Khorasani (Tehran)

3. A case of Fallopia multiflora-induced hepatotoxicity treated with acetylcysteine (abstract no. 226) Shaun L Greene (Victoria)

4. Cardiotoxic hyperkalemia as a result of canary seed ingestion (abstract no. 227) Emily S Taub (New York)

5. French health national survey on poisoning by mushrooms (abstract no. 228) Gaël Le Roux (Angers)

6. Role of superoxide dismutase in severe mushroom poisoning: a case report (abstract no. 229) Radu C Tincu (Bucharest)

Friday 19 May 2017 (afternoon)Session chair: Mark Zammit

15:45 – 16:15 1. Can duration of hemodialysis be estimated based on the on-arrival laboratory tests and clinical manifestations

in methanol-poisoned patients? (abstract no. 245) Hossein Hassanian-Moghaddam (Tehran)

2. Emergency anesthetic management of dapsone-induced methemoglobinemia: a case report (abstract no. 246) Radu C Tincu (Bucharest)

3. Fetal deaths as reported to the US National Poison Data System, 2011-2015 (abstract no. 247) David Goldberger (Philadelphia)

4. Role of a poison centre in the management of suspected rabies infections (abstract no. 248)Davide Lonati (Pavia)

20

POSTERS

Wednesday 17 May 2017 Analytical and forensic toxicology (abstracts 37-45) Antidotes (abstracts 46-52) Heavy metals poisoning (abstracts 53-59) Miscellaneous (abstracts 60-71) Pesticide poisoning (abstracts 72-76) Poisons centre activities (abstracts 77-92) Toxicosurveillance (abstract 93) Veterinary toxicology (abstracts 94-104)

Thursday 18 May 2017 Adverse effects (abstracts 139-152) Drug abuse poisoning (abstracts 153-187) Medication poisoning (including paracetamol and anti-convulsive drugs) (abstracts 188-219)

Friday 19 May 2017 Animal poisoning (abstracts 255-268) Epidemiology of poisoning (abstracts 269-279) Household products poisoning (abstracts 281-286) Mechanisms of toxicity and basic research (abstracts 287-292) Plant and mushroom poisoning (abstracts 293-305) Poisoning management (including pre-hospital management) (abstracts 306-327 & 192)

21

NOTES

22

The EAPCCT gratefully acknowledges support from the following organisations:

CONGRESS SUPPORTERS AND SPONSORS

Federal Office of Public Health, Switzerland

SCAHT - Swiss Centre for Applied Human Toxicology

The member companies of the KGF (Kontaktgruppe für

Forschungsfragen), BASF, F. Hoffmann-La Roche AG,

Novartis and Syngenta

Fundación Española de Toxicología Clínica fe

otc

fundación española de toxicología clínica

Kanton Basel-Stadt

23

The EAPCCT gratefully acknowledges support from the following exhibitors:

CONGRESS SUPPORTERS AND SPONSORS

Taylor & Francis Group

Flynn Pharma

Laboratoires SERB

Prevor

Truven Health Analytics. IBM Watson Health

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Toxicological analysis and contribuon to diagnosis and paent management in clinical toxicology

EAPC

CT 2

017

37th

Con

gress

of the

Europ

ean A

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tion

of Po

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Cen

tres a

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PR

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RA

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GL

AN

CE

www.eap

cct.org

#ea

pcc

t20

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