DETAILED SCIENTIFIC PROGRAMME

DETAILED SCIENTIFIC PROGRAMME

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PRECONGRESS

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PRE-CONGRESS

FUNDAMENTAL AND APPLIED STUDIES IN POISONING – AN OVERVIEW OF THEIR ROLE

FOR THE CLINICAL TOXICOLOGIST

09:00-09:01 Welcome and opening

Martin Wilks, Switzerland, and Paul Dargan, United Kingdom

Session 1

Moderators: Martin Wilks, Switzerland, and Paul Dargan, United Kingdom

09:01-09:30 In silico studies: Modelling drug-induced liver injury using machine learning

Felix Hammann, University Hospital Bern, Switzerland

09:30-10:00 Use of in vitro studies for prediction of clinical NPS toxicity

Dino Lüthi, Medical University of Vienna, Austria

10:00-10:30 Animal models to understand the mechanisms of toxicity and optimise poisoning

management

Bruno Mégarbane, Paris-Diderot University, France

At the end of this session the audience should be able to:

Explain the potential and limitations of machine learning and cheminformatics for drug induced liver injury.

Name at least one advantage and one disadvantage of in vitro research as predictor of the clinical toxicity of NPS.

To understand how experimental animal models are designed and to which level they contribute to understand toxicity in humans.

10:30-11:00 Rest break

11:00 Session 2

Moderators: Bruno Megarbane, France and Katrin Faber, Switzerland

11:00-11:30 Genomics, pharmacogenomics and genotyping, an overview for the clinical

toxicologist

Alexander Jetter, University Hospital Zürich, Switzerland

11:30-12:00 Identifying exposure biomarkers with metabolomics: the example of dioxin

Serge Rudaz, Université de Genève, Switzerland

12:00-12:30 Pharmacokinetic-pharmacodynamic modelling in clinical toxicology

Lucie Chevillard, Paris Descartes University, France


Describe the opportunities and the limits of pharmacogenomics in patient care.

Know how metabolomic approaches could be useful to tackle the impact of toxicant such as acute dioxin exposure on human metabolism.

Learn the interest of different methods of pharmacokinetics analysis and how to relate PK to the markers of intoxication (pharmacodynamic) to better understand the possible mechanisms involved.

12:30-13:45 Lunch break

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13:45 Session 3

Moderators: Evangelia Liakoni, Switzerland, and Geert Verstegen Belgium

13:45-14:15 Cell cultures: In vitro human cell cultures to predict drug toxicity

Dirk Steinritz, Institut für Pharmakologie und Toxikologie der Bundesweh, Münich,

Germany

14:15-14:45 A general roadmap to investigate the main mechanisms of mitochondrial toxicity

Bernard Fromenty, INSERM, Rennes, France

14:45-15:15 Organ chips: principles and applications for clinical toxicology

Pierre-Jean Ferron, INSERM, Rennes, France


Explain the benefit but also the limitations of in vitro cell culture models for predicting acute drug toxicity.

Describe how xenobiotics disrupt mitocondrial metabolic pathways and the methods of investigation for these.

Overview of the different models of organ on chips and organoids used to identify toxicity mechanism: from the clinical case to the cell biology laboratory.

15:15-15:45 Rest break / (opportunity for short individually arranged satellite meetings)

15:45 Session 4

Moderators: Laura Hondebrink, The Netherlands and Piotr Kabata, Polonia

15:45-16:15 Imaging in neuropharmacology: applications to clinical toxicology

Nicholas Tournier, CEA, Orsay, France

16:15-16:45 Neuro-electrophysiology - principles and applications in organophosphate

poisoning

Tharaka Dassanayake,University of Peradeniya, Sri Lanka

16:45-17:15 Understanding individual differences from big data analysis of patient records

Heikki Nikkanen, Mount Auburn Hospital, Boston, USA


Outline how PET imaging and specific biomarkers may be utilised to study kinetics and interactions in the CNS.

Outline the basis of neuroelectrophysiological tests that assess peripheral nerves, neuromuscular junctional transmission and the central nervous system in organophosphate poisoning.

Describe the strengths and weaknesses of manipulation of large data sets for meaningful research in toxicology.

17:15 End of Pre-congress symposium 2021

Moderators: Laura Hondebrink, The Netherlands and Piotr Kabata, Polonia

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MAIN CONGRESS

26 to 28 May 2021

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DAY 1

08:45-09:00 WELCOME AND OPENING / INTRODUCTION TO THE CONFERENCE PLATFORM

Hosts: Horst Thiermann, EAPCCT President

Lotte Hoegberg, EAPCCT/SMC Chair

CAUSTIC INGESTION SYMPOSIUM

Moderators: - Ingrid Berling, Australia and Davide Lonati, Italy

09:00-09:20 Epidemiology of caustic ingestions in children and adults

Maren Hermans-Clausen, University Hospital, Freiburg, Germany

09:20-09:40 The role of CT in the assessment of oral caustic injury

Pierre Cattan, Saint-Louis Hospital, Paris, France

09:40-10:00 The role of endoscopy in the assessment of oral caustic injury

Filippo Torroni, Bambino Gesu' Children's Hospital, Rome, Italy

10:00-10:20 Risk factors for oesophageal stricture in alkali ingestion in children

Viorela Nitescu, Bucharest, Romania (2020- Abstract 199)

10:20-10:40 Effectiveness of endoscopic application of human collagen Type 1 in the treatment

of oesophageal chemical burns

Anastasia Yu Simonova, Moscow, Russia (2021- Abstract 293)

10:40-11:00 Management of caustic injury and the indications for surgical intervention

Wolfram Kluwe, University Hospital, Freiburg, Germany

11:00-11:10 Questions & Answers to the Caustic Ingestion Symposium speakers


Describe factors influencing outcome of caustic ingestions regarding patterns of exposure, characteristics of agent involved and age of exposed patients.

Outline the potential benefits of CT in the emergency management of caustic injuries and discuss the optimal use of endoscopy in the emergency management of caustic injuries in children.

Explain the main points of the pathophysiology of caustic injuries and describe the management in acute situations and in the follow up.

11:10-11:40 Rest break and AUTHORS WITH POSTERS (Morning grouping)

ORAL PLATFORM AND SHORT ORAL PRESENTATIONS

Moderators: Maren Hermans-Clausen Germany and Patricia Casey, Ireland

11:40-11:50 Characteristics and clinical features of patients attending UK emergency

departments with analytically-confirmed exposure to the synthetic cannabinoid

MDMB-4EN Pinaca

Simon HL Thomas, Newcastle, United Kingdom (2021 Abstract 294)

11:50-12:10 Changing patterns of synthetic cannabinoid receptor agonists encountered in UK

emergency departments

Simon HL Thomas, Newcastle, United Kingdom (2021 Abstract 295)

12:10-12:20 Patterns of teenage heroin exposures reported to the US poison centres

Saumitra Vijay Rege, Charlottesville, Virginia, USA (2021- Abstract 296)

12:20-12:30 Questions & Answers to the Oral platform and Short Oral Presentation speakers

12:30-13:00 Lunch

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13:00-13:30 AUTHORS WITH POSTERS (Lunchtime grouping)

ALCOHOL AS A CO-INGESTANT IN THE POISONED PATIENT

Moderators: Michael Eddleston, United Kingdom and Knut Erik Hovda, Norway

13:30-13:50 Alcohol as a co-ingestant with stimulant recreational drugs and energy drinks

Chris Yates, SAMU 061 Balears, Palma de Mallorca, Spain

13:50-14:10 Alcohol as a co-ingestant with benzodiazepines and/or other CNS depressants

Tobias Zellner, TUM School of Medicine, Technical University of Munich, Munich,

Germany

14:10-14:30 Interactions between alcohol and organophosphate insecticide poisoning

Michael Eddleston, University of Edinburgh, UK

14:30-14:50 Poisonings where ethanol may be acutely protective – paracetamol

Kim Dalhoff, Bispebjerg University Hospital, Copenhagen, Denmark

14:50-15:10 Poisoning where ethanol is protective - the toxic alcohols

Ken McMartin, Louisiana State University Health Sciences Center, Shreveport, USA

15:10-15:20 Fomepizole during continuous renal replacement therapy, an observational study

Yvonne Lao, Oslo, Norway (2021 Abstract 297)

15:20-15:30 Questions & Answers to the Alcohol as a Co-ingestant in the Poisoned Patient

speakers


Discuss mechanistically how alcohol complicates management of stimulant drug ingestion and provide specific examples.

Describe the effect of ethanol when co-ingested with CNS-depressants in regard to symptoms, clinical management and outcome.

Explain how blood alcohol concentration interacts with insecticide dosing to worsen outcome in OP insecticide poisoning.

Listing clinically relevant studies of the effect(s) of alcohol on paracetamol toxicity, explain the possible protective mechanism of alcohol and debate the pros and cons of alcoholuse in the treatment of paracetamol poisoning.

Describe how ethanol can be used to treat methanol and ethylene glycol poisonings

UPDATE FROM THE GUIDELINES COLLABORATIVE GROUP

Moderators: Alex Campbell, United Kingdom and Lotte Hoegberg, Denmark

15:30-15:45 STATUS: QT prolongation in poisoning, Activated Charcoal, Paracetamol

Sophie Gosselin, CISSS de la Montérégie-Centre, Montreal, Canada

15:45-16:15 Rest break and AUTHORS WITH POSTERS (Afternoon grouping)

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FELLOWS LECTURE

Moderators: Allister Vale, United Kingdom and Hugo Kupferschmidt, Germany

16:15-16:20 Introduction

16:20-17:15 Inaugural Fellows Lecture: “Vaping Induced Lung Injury”

David Christiani, Harvard University , Boston, USA


Understand the exposures contained in current electronic vaping products in common use.

Understand the Acura effects of vaping aerosol exposure on the henna lung.

Understand the clinical syndromes associated with vaping.

Understand management and prevention interventions in EVALI. 7

17:15 END OF DAY 1

Hosts: Allister Vale, United Kingdom and Hugo Kupferschmidt, Germany

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DAY 2

08:45-09:00 WELCOME DAY 2 / RE-INTRODUCTION TO THE CONFERENCE PLATFORM

Host: Alex Campbell, United Kingdom

APAMT SYMPOSIUM: TOXICOVIGILANCE DURING COVID-19 IN THE ASIAN-PACIFIC REGION

Moderators: Nick Buckley, Australia and David Wood, United Kingdom

09:00-09:05 Introduction to the session

Nick Buckley, Australia

09:05-09:25 Covid-19, disinfection and methanol poisoning: A report from Iran

Hossein Hassanian-Moghaddam, Iran

09:25-09:45 Toxic disasters in India during Covid-19 pandemic

Ashish Bhalla, India

09:45-10:00 Caveat Emptor: Covid-19 and impacts on surPRISE illicit drug poisonings in Australia

Thanjira Jiranantakan, Australia

10:00-10:20 Ketamine Adulteration in Thailand: the issue of supply and demand during Covid-19

Summon Chomchai, Thailand

10:20-10:30 Questions & Answers to the Session


Learn about significant toxic exposures during COVID-19 pandemic in the Asian-Pacific area

Understand key steps of toxicovigilance taken in an Asian-Pacific context

Apply lessons learned about the signal identification, data gathering, risk assessment and responses measures to their local context.

10:30-11:00 Rest break and AUTHORS WITH POSTERS (Morning grouping)


Moderators: Gabija Laubner, Lithuania and Katrin Faber, Switzerland

11:00-11:20 Unintentional exposure to immediate-release Tramadol in ≤6-year old children: A

nationwide French Poisons Control Centre study

Dominique Vodovar, Paris, France (2021- Abstract 298)

11:20-11:30 Enquiries to the National Poisons Information Centre, Ireland concerning patients

who required tracheal intubation

Myles Monaghan, Dublin, Ireland (2021 Abstract 299)

11:30-11:35 Questions & Answers to the Oral Platform and Short Oral Presentations

11:40-12:30 FELLOWS MEETING

Hosts: 3 - Allister Vale, Hugo Kupferschmidt, Ian Whyte

11:40-12:30 Lunch

12:30-13:00 AUTHORS WITH POSTERS (Lunchtime grouping)

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YOUNG INVESTIGATORS AWARD

Moderators: Mark Zammit, Malta and Piotr Kabata, Polonia

13:00-13:05 Introduction to the session

13:05-13:20 A 2 bag intravenous acetylcysteine regimen results in fewer treatment delays in the

management of paracetamol overdose

Anselm Wong, Australia (YIA 2021- Abstract 300)

13:20-13:35 Decision support for toxin prediction using artificial intelligence

Tobias Zellner, Munich Germany (YIA 2021- Abstract 301)

13:35-13:50 "Flu" the Looking-Glass: observational poison center study evaluating adverse

events secondary to flumazenil administration over time

Varun Vohra, USA (YIA 2021 -Abstract 302)

13:50-14:00 Collection of votes and Announcement of the winner of YIA

COVID-19 SYMPOSIUM

Moderators: Evangelia Liakoni, Switzerland and Erik Lindeman, Sweden

14:00-14:20 Impact of COVID on poisons centres - a European perspective

Davide Lonati, Pavia Poison Control Centre, Pavia, Italy

14:20-14:40 Impact of COVID-19 on poisons centers - a US perspective

Diane Calello, Rutgers New Jersey Medical School, USA

14:40-15:00 The impact of the first wave of COVID-19 on Poisons Centre (PC) activities in 4

European countries: a pilot study

Laura Hondebrink, Utrecht, Netherlands (2021- Abstract 303)

15:00-15:10 A networked approach to a SARS-COV-2 information hotline in the state of Florida -

design, implementation and lessons learned

Alfred Aleguas, Tampa, Florida, USA (2021 -Abstract 304)

15:10-15:20 Virtual education and networking during COVID: the ACMT COVID-19 Webinar

series

Paul Wax, ACMT, Phoenix, USA

15:20-15:30 Questions & Answers to the Oral Platform Session speakers


Describe the effect of pandemic waves on Europe Health System and how the EAPCCT working-group is investigating the influence of the COVID-19 pandemic on the work of European Poison Control Centres (PCCs).

Describe the process of expanding the role of a regional poison center to provide a 24/7 public health hotline in response to the COVID-19 pandemic, as an information service as well as a critical component of surveillance and response.

Describe the opportunities for virtual toxicology education and networking during a pandemic.


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COVID-19 SYMPOSIUM

Moderators: Ana Ferrer Dufol, Spain and Paul Dargan, United Kingdom

16:00-16:20 Toxicity of drugs and "other treatments" - Toxicity of therapeutic drugs used for

COVID or overview of the drugs used to treat COVID

Caroline Samer, Geneva University Hospitals, Switzerland

16:20-16:40 Toxicity of drugs and "other treatments" - Use of non-recommended toxic

treatments (toxic alcohols/cleaning products etc.

Craig Smollin, University of California, San Francisco, USA

16:40-17:00 Impact of COVID-19 on recreational drugs in Europe - an overview from the

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)

Isabelle Giraudon, EMCDDA, Lisbon, Portugal

17:00-17:20 Intentional poisoning cases reported to the National Poisons Information Centre

during the initial lockdown phase of COVID-19 Public Health restrictions

Edel Duggan, Dublin, Ireland (2021 Abstract 305)

17:20-17:30 Recreational drug toxicity Emergency Department presentations during the initial

months of the COVID-19 pandemic

Juan Ortega Pérez, Palma de Mallorca, Spain (2021- Abstract 306)

17:30-17:40 Questions & Answers to the Oral Platform Session speakers


List the repurposed and new drugs used in the context of COVID19 and outline the available clinical data regarding their efficacy and safety for COVID19 prophylaxis and treatment

Describe the mechanism of toxicity and treatment of patients exposed to sodium chlorite.

To learn about the impact of COVID-19 on recreational drugs in Europe (including on market, use, harm and treatment) based on a 'Trendspotter analysis' of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).

17:40 END OF DAY 2

Hosts: Ana Ferrer Dufol, Spain and Paul Dargan, United Kingdom

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DAY 3

0845-0900 WELCOME DAY 3 / RE-INTRODUCTION TO THE CONFERENCE PLATFORM

Host: Alex Campbell , United Kingdom

DRUG FORMULATION AND ITS IMPORTANCE IN THE POISONED PATIENT

Moderators: Davide Lonati, Italy and Anselm Wong, Australia

09:00-09:20 The impact of new drug formulations on the assessment of the poisoned patient

Andis Graudins, Monash Health, Melbourne, Australia

09:20-09:35 The pharmacology of pharmacobezoars

Lotte Hoegberg, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

09:35-09:55 Management of pharmacobezoars

Soeren Boegevig, Copenhagen University Hospital Bispebjerg, Copenhagen,

Denmark

09:55-10:10 Misuse of prescriptions medicines by routes other than the intended route of use

David Wood, Guy's and St Thomas' NHS Foundation Trust, London, UK

10:20-10:30 Questions & Answers to the Drug Formulation symposium


Explain the pharmacokinetic and pharmacodynamic features of poisoning with various newer drug formulations that can influence the risk assessment and initial management of the poisoned patient.

Identify known physicochemical properties of pharmaceutical preparations prone to cause pharmacobezoar formation - the formation and degradation.

Describe ways to identify the formation of pharmacobezoars and possible treatment modalities in the poisoned patient where their formation is suspected or identified.

Understand the frequency of and methods by which prescription medicines can be used by routes other than the intended licenced route(s) of use.

10:30-11:00 Rest break and Authors with posters (Morning grouping)

LOUIS ROCHE LECTURE

11:00-11:15 Introduction and presentation of the Louis Roche Lecturer

Horst Thiermann, EAPCCT President

11:15-12:00 Improving the evaluation, management and outcome of cardiotoxicant-poisoned patients - still a challenge for clinical toxicologists Bruno Mégarbane, Paris-Diderot University, France


Understand the contribution of the proposed different therapies in cardiotoxicant poisonings

12:00-12:30 Authors with posters (Lunchtime grouping)

12:30-13:30 Lunch

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13:00-14:15 GENERAL ASSEMBLY

Hosts: Horst Thiermann (EAPCCT President),

Davide Lonati (EAPCCT General Secretary),

Sergej Zakharov and Bruno Mégarbane (EAPCCT Treasurers)

TOXICOLOGY 2.0 SYMPOSIUM

Moderators: Chris Yates, Spain and Mark Zammit, Malta

14:15-14:30 Games for dissemination of poison prevention education to the public

Yu-Hao Cheng, Taiwan National Poison Control Center, Taipei, Taiwan

14:30-14:45 Artificial intelligence in medicine and toxicology: current trends and outlook

Matjaž Kukar, University of Ljubljana, Slovenia

14:45-14:55 Using Artificial Intelligence to understand recreational drug usage and toxicity from

internet forums

Michael Chary (2020- Abstract 098)

14:55-15:10 The role of data from drug user forums in determining recreational drug and NPS

toxicity

Sage Wiener, SUNY Downstate Health Sciences University, New York, USA

15:10-15:25 Google metrics and twitter to monitor recreational drugs and NPS trends

Jean Marie Perrone, University of Pennsylvania , Philadelphia, USA

15:25-15:35 The geospatial and linguistic dynamics of conversations on Twitter about vaping

Michael Chary (2020 -Abstract 099)

15:35-15:50 Robotic wastewater analysis to understand community consumption of opioids,

cocaine, NPS and methamphetamines

Claire Duvallet, Biobot Analytics, Boston, USA

15:50-16:05 Web monitoring tools to monitor trends in prescription medicine misuse

Rick Dart, Denver Health and Hospital Authority, Denver, USA

16:05-16:20 Ingestible Electronics and Robotic Systems to measure medication adherence and

drug use events

Peter Chai, Brigham and Women's Hospital, Boston, USA

16:20-16:35 Telemedicine as an assessment tool in chemical weapon attacks, experience in Syria

with global implications

Tim Erickson, Brigham Health / Harvard Medical School, Boston, USA

16:35-16:45 Questions & Answers to the Toxicology 2.0 speakers


Identify important poisoning trends.

State the features of poisoning events in different age groups.

Describe the importance and challenges of poison prevention education.

List two effective strategies for delivering poison prevention knowledge to children.

Describe various modern artificial intelligence techniques, applicable in different scenarios and types of data (tabular data, images, text), as well as determine and decide which particular problems are suitable for application of AI techniques.

Explain the role of online drug information forums in both reflecting and driving patterns of drug use, and their utility and limitations in studying these patterns.

Describe tools in Google and Twitter that can help characterize novel psychoactive substance trends.

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Explain the basic concepts behind using wastewater epidemiology to measure population-level exposure and consumption of opioids, cocaine, NPS and methamphetamines and describe results from a pilot study applying wastewater epidemiology to map opioid consumption in a US municipality.

Understand the appropriate use of data derived from various types of social media.

Understand the current state of art in ingestible electronics and the principles of biosensing in drug testing.

Describe current use of telemedicine and other emerging technologies in the setting of chemical weapon attacks.



Hosts: Horst Thiermann, Munich, Germany and Lotte Hoegberg, Copenhagen, Denmark

17:15-17:25 Foodborne botulism: a large outbreak in Sicily

Azzurra Schicchi, Pavia, Italy (2021 Abstract 307)

17:25-17:45 Shiitake Dermatitis: a French nationwide study 2014-2019

David Boels, Nantes, France (2021- Abstract 308)

17:45-17:50 Questions & Answers to the Oral platform and Short Oral Presentation speakers

17:50 END OF DAY 3, END OF EAPCCT 2021 VIRTUAL CONFERENCE

Hosts: Horst Thiermann, Munich, Germany and Lotte Hoegberg, Copenhagen, Denmark

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E-POSTERS

(sorted by topic) Adverse reactions from medications 219 Clozapine-induced anemia: a case report

Andrea Giampreti, Emergency care, Poison Control Center, Bergamo, Italy.

Lunchtime Posters - Room 07

220 Lacosamide-induced recurrent ventricular fibrillation

Andrea Giampreti, Emergency care, Poison Control Center, Bergamo, Italy.


222 Bleeding events due to warfarin therapy: how much does it cost?

Gabija Laubner, Toxicology centre, Vilnius University Faculty of Medicine, Clinic of Anaesthesiology

and Intensive Care, Toxicology centre, Vilnius, Lithuania.


223 Phenytoin intoxication associated with omeprazole administration in a child with CYP2C9

polymorphism

Marco Marano, Emergency Department PICU. Regional Pediatric Poison Control Center., Bambino

Gesù Children Hospital, Rome, Italy.


226 Olanzapine overdose-induced agranulocytosis

Gordana Vukovic Ercegovic, Department of Clinical Toxicology, National Poison Control Center,

Military Medical Academy, Belgrade, Serbia.


227 From kitchen to clinical use, to emergency department admission: an Italian story about

curcumin

Francesco Gambassi, Toxicology Unit, Poison Control Center of Careggi University Hospital, Florence,

Italy.


229 Bowel perforation due to methotrexate therapeutic error: a case report.

Marco Cirronis, Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and

Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of

Pavia (Italy), Pavia, Italy.


390 Pharmacovigilance for identification and prevention of therapeutic errors

Anna Celentano, Milan Poison Control Center, ASST Grande Ospedale Metropolitano Niguarda,

Milan, Italy.


391 Lamotrigine-induced Stevens-Johnson syndrome: a case report

Andrea Giampreti, Emergency Department, Poison Control Center, Bergamo, Italy.


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392 Dimethyl fumarate-induced hepatotoxicity confirmed by biopsy

Ophir Lavon, Clinical Pharmacology and Toxicology Unit, Carmel Medical Center, Haifa, Israel.


224 Two case of opioid withdrawal syndrome precipitated by alcohol dependence treatment

with nalmefene successfully treated with morphine

Jonas Moens, Belgian Poison Centre, Brussels, Belgium.

Afternoon Posters - Room 09

228 Accidental injection of pseudorabies pigs vaccine in humans

Azzurra Schicchi, Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and


Pavia, Pavia, Italy.


393 Iodoform medications may cause iodine toxicosis: two case reports





394 Fooled by adrenaline: a pyrogenic-like reaction during treatment of a common European

viper bite

Anton Gustafsson, Swedish Poisons Information Center, Swedish Poisons Information Center,

Stockholm, Sweden.


395 Symptomatic therapeutic errors in the elderly: a case study

Carlo A Locatelli, Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and




396 Severe adverse effects after a second dose of paliperidone palmitate long-acting injectable

administration: a case report

Davide Lonati, Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and




397 Soft capsules formulated with ethanol: unexpected disulfiram-ethanol reaction after one

dosage of ciclosporin

Jonas Moens, Belgian Poison Control Centre, NEDER-OVER-HEEMBEEK, Belgium.


398 Effect of a 12-hour intravenous acetylcysteine (SNAP) regimen on the International

Normalized Ratio (INR)

Ruben Thanacoody, Newcastle University, Newcastle Upon Tyne, United Kingdom.


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Alcohol as a co-ingestant 001 Effect of ethanol coingestion in patients with central nervous system (CNS)-depressant

intoxication

Eva-Carina Heier, Division of Clinical Toxicology and Poison Control Centre Munich, Department of

Internal Medicine II, TUM School of Medicine, Technical University of Munich, Munich, Germany.


031 Adults admitted to the emergency department of a university hospital in Belgium for acute

poisoning with ethanol as a co-ingestant: characteristics and direct medical costs

Anne-Marie K Descamps, Belgian Poison Centre, Brussels, Belgium.


Analytical and Forensic Toxicology - including bedside testing 204 Bedside formate analysis in methanol poisoned patients: a pilot study

Knut Erik Hovda, The National CBRNE Centre of Medicine, Department of Acute Medicine, Oslo

University Hospital, Oslo, Norway.

Morning Posters - Room 09

210 False positive result on colorimetric methanol screening test: report of two cases with

hyperglycaemia

Jones CM Chan, Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong.


203 Emergent toxicological molecular screening test on ICU admission: can it be trusted?

Bruno Mégarbane, Department of Medical and Toxicological Critical Care, Lariboisière Hospital,

Paris-Diderot University, INSERM UMRS-1144, Paris, France.


211 The value of post-mortem toxicology in deciding whether a death is drug-induced

James M Coulson, Clinical Pharmacology, Cardiff University, Cardiff, United Kingdom.


216 Laboratory practice variations complicate poison centre recommendations for massive

paracetamol overdose

Timothy C Backus, NYU School of Medicine, New York, United States.


218 Poison center recommendations for methylxanthine toxicity may be complicated by limited

access to theophylline measurements

Timothy C Backus, NYU School of Medicine, New York, United States.


361 Biological sample collection in the emergency department and laboratory substance abuse

investigation and confirmation: a methamphetamine case report


Milan, Italy.


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362 Post-mortem ethanol concentrations

James M Coulson, All Wales Therapeutics & Toxicology Centre, Cardiff University, Cardiff, United

Kingdom.


Caustic ingestion 207 A one-year retrospective study of caustic injury in adults admitted to a toxicology

department

Julia V Radenkova-Saeva, Clinic of Toxicology, UMHATEM "N.I.Pirogov", Sofia, Bulgaria.


Covid-19 and toxicology 402 Acute poisoning in Moscow during COVID-19 restrictive measures

Anastasia Yu Simonova, Toxicological department, N.V. Sklifosovsky’ Research Institute of

Emergency Medicine, Moscow, Russian Federation.


403 Unintended consequences of public health measures: exposures to alcohol-based hand

sanitisers during the COVID-19 pandemic 2020

Patricia Casey, National Poisons Information Centre of Ireland, Dublin, Ireland.


404 Increased exposures to alcohol-based hand sanitizers reported by an Italian Poison Center

during the COVID-19 pandemic


Milan, Italy.


405 Pediatric eye injuries related to public location of alcohol-based hand sanitizers during the

first pandemic COVID-19 context: French Poison Control Centers data

Alexis Descatha, PCC, Ester Unit (IRSET U1085), UNIV Angers, CHU Angers, Univ Rennes, Inserm,

EHESP, Irset,, Angers, France.


406 Has the COVID-19 pandemic changed the pattern of poisoning cases attending Emergency

Departments?

Ana Ferrer-Dufol, Unit of Clinical Toxicology, Clinical University Hospital, Zaragoza, Spain.


407 The only thing we have to fear is fear itself: inadvertent disopyramide toxicity during the

COVID-19 pandemic

Emma R Furlano, Division of Medical Toxicology, Ronald O. Perelman Department of Emergency

Medicine, NYU Grossman School of Medicine, New York, United States.


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408 Nicotine does not affect SARS-CoV-2 in-host viral kinetics in a modeling and simulation study

Charlotte Kern, Department of General Internal Medicine, Clinical Pharmacology and Toxicology,

Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern

University Hospital, University of Bern, Bern; Graduate School for Health Sciences, University of

Bern, Bern, Bern, Switzerland.


409 A human exposure to chlorine dioxide solution...not the solution

Valle Molina, Emergencie, Complejo Hospitalario de Navarra, pamplona, Spain.


410 Changes in the epidemiological profile of poisonings during COVID-19: differences between

the first half of 2019 and 2020

Zanina Pereska, University Clinic of Toxicology, Skopje, Macedonia.


411 Multiple factors in a COVID-19 patient leading to an elevated 5-oxoproline as cause of high-

anion gap metabolic acidosis: a case report

Marian Piqueur, Departement of Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp,

Belgium.


Drugs of abuse and NPS poisoning 116 Massive gamma-hydroxybutyric acid overdose resulting in severe metabolic acidosis

requiring continuous venovenous haemofiltration

Anselm Wong, Victorian Poisons Information Centre, Austin Toxicology and Emergency Department,

Austin Health, Victoria, Australia.


138 Just “nanging” around: case series of neurological sequelae from chronic nitrous oxide abuse

Angela L Chiew, Clinical Toxicology Unit, Prince of Wales Hospital, Sydney, Australia.


197 Analytically-confirmed exposure to new psychoactive substances in patients with severe

clinical toxicity in the UK, 2015-2018: a report from the IONA study

Simon H Thomas, Narional Poisons Information Service, Newcastle Hospitals NHS Foundation Trust,

Newcastle, United Kingdom.


198 Increasing abuse and addiction to nitrous oxide (N2O): still a legal high in Denmark

Lotte CG Hoegberg, Department of Anaesthesiology, The Danish Poisons Information Centre,

Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.


309 Severe cardiac and neurological toxic effects due to synthetic cannabinoid cumyl-pegaclone

(SGT-151) alone: a case report

Andrea Giampreti, Bergamo Poison Control Center, Bergamo Poison Control Center, Bergamo, Italy.


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310 Beta-hydroxybutyrate closed the gap in a sober patient with high anion gap metabolic

acidosis: a case report

Marian Piqueur, Department of Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp,

Belgium.


117 Hyperemesis and acute kidney injury following a “rebirth” ceremony with kambô and iboga

in the Netherlands

Marian Piqueur, Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium.


126 Clinical effects following the use of freely available herbal drugs: the toxicity of “Happy

Caps”

Antoinette JHP Riel, Dutch Poisons Information Center(DPIC), Univesity Medical Center Utrecht,

Utrecht University, Utrecht, Netherlands.


131 Recreational nitrous oxide use rises dramatically after change in EU legislation

Antoinette JHP Van Riel, Dutch Poisons Information Center, University Medical Center Utrecht,

Utrecht Univeristy, Utrecht, Netherlands.


136 Treating patients with opioid overdose at a primary care emergency outpatient clinic: a cost-

minimization analysis

Odd Martin Vallersnes, Department of General Practice, University of Oslo, Oslo, Norway.


137 Self-discharge during treatment for acute recreational drug toxicity: an analysis of four-years

of Euro-DEN Plus presentations



150 Treatment with naloxone and follow up after opioid overdose outside of hospital:

observational data 2014-2018 in Oslo, Norway

Arne K Skulberg, Department of Circulation and Medical Imaging, Norwegian University of Science

and Technology, Trondheim, Norway; Pre-hospital Division, Air Ambulance Department, Oslo

University Hospital, Oslo, Norway ; The Norwegian Air Ambulance Foundation, Oslo, Norwa,

Trondheim, Norway.


158 Change of quality of life in prescription opioid patients after rapid opioid detoxification

Gabija Laubner, Republican Vilnius University Hospital, Centre of Toxicology; Vilnius University

Faculty of Medicine, Vilnius University, Vilnius, Lithuania.


160 First identification of synthetic cannabinoid 5F-MDMB-PICA in Italy

Carlo Alessandro Locatelli, Pavia Poison Control Centre - National Toxicology Information Centre -

Clinical and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and

University of Pavia, Pavia, Italy.


24

313 Poisoning by central stimulant drugs in Oslo, Norway



314 Acute poisoning from concurrent use of opioids and amphetamine



315 Acute recreational drug toxicity among young patients



316 Acute poisonings involving cannabis in Oslo, Norway



317 Psychosis associated with acute recreational drug toxicity



119 3,4-Methylenedioxy-α-pyrrolidinohexiophenone (MDPHP): four severe confirmed

intoxications

Dieter Müller, Clinical Toxicology Laboratory, GIZ-Nord Poisons Centre, University Medical Center

Göttingen, Georg-August-University, Göttingen, Germany.


143 Methadone poisonings admitted to the ICU: investigation of the predictive value of plasma

methadone concentration and the required naloxone dose regimen




147 Severe acidosis and prolonged coma after a massive overdose of gamma-hydroxybutyrate

(GHB)

Johanna Nordmark Grass, Swedish Poisons Information Centre, Stockholm, Sweden.


155 The development of poisonings with illegal substances: data from the Danish Poisons

Information Centre (DPIC)

Dorte F Palmqvist, Department of Anaesthesiology, The Danish Poisons Information Centre,



318 E-liquid sold as CBD e-liquid containing XRL-11: 4 cases reported. A warning signal to health

authorities and e-cigarettes users

Francis Grossenbacher, University Hospital Reims, Clinical Toxicologist Emergency Department,

Reims, France.


319 Significant cannabidiol (CBD) urine concentration in a young male admitted after using an e-

cigarette obtained from a street market

Francis Grossenbacher, University Hospital Reims, Clinical Toxicologist Emergency Department,

Reims, France.


25

320 Swedes like their O-juice from Florida and their E-juice from California

Sonny Larsson, Swedish Poisons Information Center, Swedish Poisons Information Center,

Stockholm, Sweden.


321 Hydroxyphencyclidines (OH-PCPs), fluoroamphetamine (FA) and fluoromethamphetamine

(FMA): an explosive NPS mixture and a challenge for appropriate sedation in a severely

intoxicated patient patient.





322 Recreational, inhalational misuse of hyoscine butylbromide (Buscopan®) tablets as reported

to the UK National Poisons Information Service

Emma J Moyns, National Poisons Information Service (Birmingham Unit), Birmingham, United

Kingdom.


323 A case of crack-lung-like syndrome due to new synthetic opioid consumption with analytical

confirmation

Azzurra Schicchi, Pavia Poison Control Centre - National Toxicology Information Centre – Istituti

Clinici Scientifici Maugeri IRCCS, Pavia, Italy.


124 In-patient prescription opioid detoxification: peculiarities of consumption and treatment

outcomes

Gabija Laubner, Vilnius University, Faculty of Medicine, Vilnius, Lithuania, Vilnius University

Emergency hospital, Vilnius, Lithuania.


125 In-patient prescription opioid detoxification: gender differences and harmful habits

Gabija Laubner, Vilnius University, Faculty of Medicine, Vilnius, Lithuania, Vilnius University

Emergency hospital, Vilnius, Lithuania.


132 Analysis of drugs in blood and urine samples from suspected spiked drink victims

Odd Martin Vallersnes, Department of General Practice, Institute of Health and Society,, University

of Oslo, Oslo, Norway.


142 Transient delayed brain edema after consumption of synthetic cathinones

Sabrina Schmoll, Department for clinical toxicology and poision control centre munich, Klinikum

rechts der Isar München, München, Germany.


149 GHB overdose in nightlife settings and effectiveness of on-site harm-reduction organization

Miran Brvar, Centre for Clinical Toxicology and Pharmacology, University Medical Centre Ljubljana,

Ljubljana, Slovenia.


26

152 Acute intoxication with α-pyrrolidinohexanophenone, 4-fluoromethylphenidate and

aminopropylbenzofuran complicated with rhabdomyolysis: a case report

Gambassi Francesco, Toxicology Unit and Poison Control Center, Careggi University Hospital,

Florence, Italy.


157 Characteristics of ecstasy toxicity in a Norwegian cohort of hospitalized poisoned patients

Per Sverre Persett, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway.


324 A comparative analysis between acute ethanol poisoning and acute ethanol combined with

drugs of abuse poisoning in adolescents

Viorela Nitescu, Pediatric Poisoning Centre Emergency Clinical Hospital for Children "Grigore

Alexandrescu", Bucharest, Romania.


325 Predicting hypertension using subjective symptoms in recreational drug users at first-aid

stations at dance events

Yoram P Prins, Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht,

Netherlands.


109 Non-medical use and injection use of prescription opioids in Europe in the Non-Medical Use

of Prescription Drug (NMURx) National Surveys

Janetta L Iwanicki, Rocky Mountain Poison and Drug Safety, Denver, United States.


118 Drug abuse trends, focussing on novel psychoactive substances (NPS) over the last three

years (2016-2018) from the perspective of the Austrian Poisons Information Centre

Kinga Bartecka-Mino, Poisons Information Centre Austria, Vienna, Austria.


122 A retrospective study of observation times in a healthcare facility and 48-hour mortality

after heroin overdose with naloxone rescue

William Rushton, Office of Medical Toxicology, Department of Emergency Medicine, University of

Alabama at Birmingham, Birmingham, United States.


127 Analysis of Twitter content to explore use of modafinil and methylphenidate as drugs to

facilitate studying in the UK

David Wood, Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, United

Kingdom.


128 Non-medical use of prescription and over the counter opioids in the UK

David Wood, Clinical Toxicology, Guy's and St Thomas's NHS Foundation Trust, London, United

Kingdom.


27

140 Comparison of drugs involved in acute recreational drug toxicity presentations to the

Emergency Department in young people versus adults reported to the Euro-DEN Plus project

Alison M Dines, Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health

Partners, London, United Kingdom.


145 Mining and analysis of opioid content in longitudinal data posted in a social media forum

Jeanmarie Perrone, Emergency Medicine, University of Pennsylvania, Philadelphia, United States.


156 Global interest in tramadol and polysubstance use

Janetta Iwanicki, Rocky Mountain Poison & Drug Safety, Denver Health, Denver, United States.


326 Acute recreational drug toxicity in Ghent, Belgium. Comparison of self-reports and analytical

detection by immunoassay (IA) and mass spectrometry (MS) testing

Laurence Daveloose, Emergency medicine, UZ Ghent, Ghent, Belgium.


327 In vino veritas: accidental MDMA poisoning by illicit drug trafficking

Katrin Faber, National Poisons Information Centre, Associated Institute of the University of Zurich,

Zurich, Switzerland.


328 Frequent hospitalization for synthetic cathinone poisonings: a case series reported to the

Dutch Poisons Information Center

Johanna J Nugteren-Van Lonkhuyzen, Dutch Poisons Information Center, University Medical Center

Utrecht, Utrecht, Netherlands.


329 Exposures involving opioids and alcohol reported to the US Poison Centers

Saumitra Rege, Department of Emergency Medicine, University of Virginia, Charlottesville, United

States.


330 The Color Purple: death associated with brorphine, an emerging novel synthetic opioid

Varun Vohra, Emergency Medicine, Michigan Poison Center, Wayne State University School of

Medicine, Detroit, United States.


Epidemiology of poisoning 011 Hydrofluoric acid exposure: a five-year review of enquiries made to the UK National Poisons

Information Service (NPIS)

Michael J Beech, NPIS (Birmingham Unit), City Hospital, Birmingham, United Kingdom.


28

012 Enquiries to the National Poisons Information Centre in Ireland from ambulance control,

emergency medical dispatchers and paramedics attending poisoning incidents from 2010-2018

Edel Duggan, National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland.


014 109 toxicological inquiries for one patient

Daniela Pelclova, Toxicological Information Centre, First Medical Faculty and General University

Hospital, Prague, Czech Republic.


019 Eye injuries: case reports to the BfR from 2004 to 2018

Kathrin Begemann, Department Exposure, Federal Institute for Risk Assessment (BfR), Berlin,

Germany.


020 A worrying trend: Poisonings with pharmaceuticals in young girls in Norway

Merethe Midtervoll, Norwegian Poison Information Centre, National Institute of Public Health, Oslo,

Norway.


021 Study on e-liquids: risk of exposure and effectiveness of regulation by Tobacco Products

Directive 2

Nina Glaser, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.


025 Mortality and patient characteristics in paracetamol overdosing: a retrospective study

Soeren Boegevig, Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital,

Copenhagen, Denmark.


106 Assessment of advice given by the Danish Poisons Information Centre concerning medication

errors in nursing homes and institutions

Soeren Boegevig, Department of Clinical Pharmacology, The Danish Poisons Information Centre,



009 Colchicine: telephone enquiries to the UK’s National Poisons Information Service (NPIS) and

UK trends in TOXBASE® accesses and prescribing data

Victoria A Eagling, NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.


010 An analysis of cases of methaemoglobinaemia reported in telephone enquiries to the UK’s

National Poisons Information Service (NPIS)

Victoria A Eagling, NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.


017 Drug-induced death in the intensive care unit in France: what are the characteristics?




023 Review of drug poisoning assessment at Emergency Department

Marine Grigoryan, Toxicology and Pediatric Intensive Care Unit, Yerevan State Medical University

29

after Mkhitar Heratsi, Yerevan, Armenia.


100 Poisoning in adolescents

Patricia Casey, National Poisons Information Centre of Ireland, Dublin, Ireland.


115 The ICU Requirement Score (IRS) - does it identify poisoned patients who do not need

intensive care unit referral? A validation cohort study




344 Comparison of acute kidney injury and renal replacement therapy in patients with

rhabdomyolysis acutely intoxicated with psychotropic or chemical substances

Aleksandra Babulovska, Toxicology, University Clinic of Toxicology, Skopje, Macedonia.


345 Increasing enquiries to the Norwegian Poison Information Center (NPIC) concerning ozone

Marte S Evje, Norwegian Institute of Public Health, Norwegian Poison Information Centre, Oslo,

Norway.


346 A 10-year review of ocular exposures reported to the Irish National Poisons Information

Centre

Conor P Malone, National Health Library and Knowledge Service, HSE, Dublin, Ireland.


347 Fatalities due to acute poisoning: a one year retrospective study

Julia V Radenkova - Saeva, Clinic of Toxicology, University Hospital for Emergency Medicine „

N.I.Pirogov”, Sofia, Bulgaria.


112 Mushroom poisonings in Finland: a 15-year retrospective study

Anne Tähkäpää, Poison Information Center, University of Helsinki and Department of Emergency

Medicine and Services, Helsinki, Finland.


104 Long-term exposure to Sargassum-seaweed pollution in the French Caribbean Islands:

clinical consequences and outcome

Dabor Resiere, Critical Care Medicine, University Hospital of Martinique, Fort de France, Martinique.


Heavy Metal Poisoning 103 Mass acute thallium poisoning treated with enteral detoxification using Prussian blue and

gut lavage

Anastasyja Yu Simonova, N.V.Sklifosovsky Rtesearch Institute of Emergency Medicine, Poisonings

Treatment Department, Moscow, Russian Federation.


162 Arsenic exposure and peripheral neuropathy

Chay J Markham, Cardiff University, Cardiff, United Kingdom.


30

163 Gadolinum contrast media: old substance, new challenges

Gabija Laubner, Toxicology Centre, Vilnius University Faculty of Medicine, Clinic of Anaesthesiology

and Intensive Care, Vilnius, Lithuania.


165 Comparison of unithiol (DMPS) treatment effect in two patients with severe cobalt

intoxication

Daniela Pelclova, Toxicological Information Centre, First Medical Faculty and General University

Hospital, Prague, Czech Republic.


168 Toxicokinetics of silver and chelation unithiol (DMPS) challenge tests in argyria due to

colloidal silver

Gasper Razinger, Centre for Clinical Toxicology and Pharmacology, University Medical Centre

Ljubljana, Ljubljana, Slovenia.


412 An unsolved mystery: idiopathic thallium exposure resulting in clinically significant toxic

effects

Varun Vohra, Emergency Medicine, Michigan Poison Center at Wayne State University School of



Household Products Poisoning 046 Unanticipated sources of methanol poisoning: report of two cases

Jones CM Chan, Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong.


049 Laundry pod exposure in children: evaluation of 17 years’ of cases in a tertiary care hospital

in Italy

Marcello Montibeller, Department of Emergency. Regional Paediatric Control Center., Bambino

Gesù Children's Hospital, Rome, Italy.


351 Protective effects of hypercalcaemia in the setting of severe hypermagnesaemia

David Emmerig, Western Sydney Local Health District Toxicology Service, Western Sydney Local

Health District Toxicology Service, Westmead, Australia.


352 Caustic exposures attending the Emergency Department: results of the Spanish Toxic

Surveillance System (STSS) 2010-2019



31

008 Portal embolism in hydrogen peroxide ingestion: a case series





051 Artificial nail primer: a case series from Pavia Poison Control Centre





052 Nail glue: a beauty hazard





353 Accidental exposures to caustic drain cleaners


Milan, Italy.


354 The “lactate gap” as a useful tool to detect ethylene glycol intoxications

Dieter Geysels, Department of Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp,

Belgium.


355 A one-year review of enquiries to the UK National Poisons Information Service involving

cosmetic products

Emma J Moyns, National Poisons Information Service (Birmingham Unit), Birmingham, United

Kingdom.


356 Acute ethylene glycol poisoning: a one year epidemiological study

Julia V Radenkova - Saeva, Clinic of Toxicology, University Hospital for Emergency Medicine „

N.I.Pirogov”,, Sofia, Bulgaria.


357 Button battery ingestion: experience of the UK National Poisons Information Service (NPIS)

Simon H L Thomas, National Poisons Information Service (Newcastle Unit), Regional Drugs and

Therapeutics Centre, Newcastle upon Tyne, United Kingdom.


Mechanisms of Toxicity and Basic Research 196 Is fentanyl responsible for more severe neuro-respiratory depression than morphine? A rat

in vivo investigation




32

005 Is lithium exposure responsible for brain injuries with prolonged treatment or overdose? A

rat investigation




Occupational poisoning 175 EXP3OP study: occupational eye exposures reported to a western France poison center

Gaël Le Roux, Centre antipoison et Toxicovigilance Grand Ouest, CHU d'Angers, Angers, France.


399 Severe gasoline poisoning and its treatment. The autonomy of the lung response facing

different pathogenic agents



400 The health and blood aluminium concentration in firefighters following the Alytus tyre

recycling factory fire

Gabija Laubner, Toxicology center, Republic Vilnius university hospital, Vilnius, Lithuania.


401 A case of acute occupational exposure to sodium molybdate with determination of

molybdenum concentration





Paediatric Poisoning 057 Alcohol "abuse" among children younger 5 years




060 Overrepresentation of flavoured, orodispersible tablets in paediatric paracetamol overdoses



061 Drug-induced liver injury induced by nicotinamide

Maren Hermanns-Clausen, Poisons Information Centre, Department of Pediatrics and Adolescent

Medicine, Faculty of Medicine, Medical Center – University of Freiburg, Freiburg, Germany.


064 Pediatric and adolescent self-poisoning: a 3-year case series

Carlo Alessandro Locatelli, Pavia Poison Control Centre - National Toxicology Information Centre -




33

367 The importance of free digoxin serum concentrations: case report of an infant treated for

digoxin poisoning

Marco Marano, Pediatric Intensive Care Unit; Pediatric Poison Control Center, Children's Hospital

Bambino Gesù, Rome, Italy.


368 Fentanyl transdermal patch mistaken for wound patch: two pediatric case reports


Milan, Italy.


369 Bottles and messages revisited: circumstances of poisonings among infants under 1 year old

in Estonia

Ruth Kastanje, Poisonings Information Centre, Estonian Health Board, Tallinn, Estonia.


370 Alcohol abuse among teenagers during the vacation period: description and pattern

differences by gender

Juan Ortega Pérez, Adult emergency department. Toxicology Unit, Attending physician, Palma de

Mallorca, Spain.


372 Paediatric paracetamol overdose: reducing side-effects with the SNAP 12 hour N-

acetylcysteine regime

David G Cairney, Acute Receiving Unit, Royal Hospital for Sick Children, Edinburgh, United Kingdom.


058 Sticky eye: a pediatric case of cyanoacrylate ocular exposure

Presented By Davide Lonati, Pavia Poison Control Centre - National Toxicology Information Centre -


University of Pavia, Pavia, Spain.


063 Pediatric cannabis poisonings in France: more and more frequent and severe.

Gaël Le Roux, Centre antipoison et Toxicovigilance Grand Ouest, CHU d'Angers, Angers, France.


371 Childhood poisonings: five-years’ experience from an Italian pediatric emergency

department

Andrea Giampreti, Bergamo Poison Control Center, ASST Papa Giovanni XXIII, Bergamo, Italy.


373 Altered mental status following a large ondansetron ingestion in a toddler

Vincent Calleo, Emergency Medicine, SUNY Upstate Medical University, Syracuse, United States.


374 Severe salicylic acid intoxication with a topical skin preparation in a newborn



375 38 Weeks pregnant: managing a mother and neonate after a third-trimester acetaminophen

ingestion

Charlotte Goldfine, Emergency Medicine, Brigham and Women's Hospital, Boston, United States.


34

376 Epidemiology of pediatric benzodiazepines exposures using the National Poison Data System

Saumitra Rege, Department of Emergency Medicine, University of Virginia, Charlottesville, United

States.


Pesticide Poisoning 036 Assessment of the effectiveness of gastric lavage in organophosphorus poisoning by

quantifying pesticide in lavage fluid

Indira Madhavan, General Medicine, Associate Proferssor, Thrissur, India.


042 Human exposures to pesticides: results of a subproject of the German pilot study PiMont

Esther Feistkorn, German Federal Institute for Risk Assessment, Department Exposure, Unit

Exposure Assessment of Hazardous Products, Berlin, Germany.


358 Hepatorenal dysfunction following fipronil ingestion

Indira Madhavan, Government Medical College, Thrissur, India.


359 Malathion poisoning causing prolonged cholinergic crisis and refractory hypotension

requiring high-dose atropine treatment

Kit Rowe, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.


035 Amitraz: an unfamiliar insecticide with familiar toxicity

William Rushton, Office of Medical Toxicology, University of Alabama at Birmingham, Birmingham,

United States.


040 The impact of obidoxime on duration of hospitalization in acute organophosphate poisoning

in Muratsan University Hospital, Yerevan, Armenia, 2012-2019




041 Poisoning risk of acute exposures to repellents: results from a prospective observational

study

Maren Hermanns-Clausen, Poisons Information Centre, Department of Pediatrics and Adolescent

Medicine, Faculty of Medicine, Medical Center – University of Freiburg, Freiburg, Germany.


043 Organophosphate poisoning among children and adolescents in Armenia: a retrospective

case study




35

044 Lethal intoxication by pentachlorophenol

Francesca Maida, Pavia Poison Control Centre - National Toxicology Information Centre - Clinical

and Experimental Lab, Toxicology Unit, Maugeri Clinical and Scientific Institutes IRCCS and



360 Evaluation of biocidal product enquiries to the Austrian Poisons Information Centre, 2017

Tara Arif, Poisons Information Centre, Vienna, Austria.


Pharmaceutical Poisoning 007 The severity and mortality prediction of calcium-channel blocker poisoning in the intensive

care unit

Chun Kuei Chen, Emergency department, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.


201 Comparison of the Australian and New Zealand Referral Criteria versus the King’s College

Criteria to predict mortality or liver transplant in paracetamol overdose

Anselm Wong, Victorian Poisons Information Centre, Austin Toxicology Unit and Emergency

Department, Austin Health, Victoria, Australia.


241 Angiotensin axis antagonists increase the severity of dihydropyridine poisoning

Betty S Chan, Clinical Toxicology & Emergency Medicine, Prince of Wales Hospital, Sydney, Australia.


242 A case series of flecainide poisoning



243 Effect of serum alkalinisation on QRS narrowing in tricyclic antidepressant poisoning



244 Optimal way to achieve serum alkalinisation in tricyclic antidepressant overdose

Betty S Chan, Clinical Toxicology & Emergency Medicine, Prince of Wales Hosptial, Sydney, Australia.


246 An uncommon cause of high-anion gap metabolic acidosis after repeated supratherapeutic

paracetamol ingestion

Hwee Min D Lee, Emergency, Monash Health, Melbourne, Australia.


262 Lurasidone mono-ingestion overdoses: a case series with minimal toxicity

Andis Graudins, Clinical Toxicology Unit, Emergency Medicine Service, Monash Health and Monash

University, Dandenong, Australia.


36

331 A 1-year prospective analysis of propranolol exposures reported to the UK National Poisons


Pardeep S Jagpal, National Poisons Information Service (Birmingham Unit), Birmingham, United

Kingdom.


332 Intravenous pentobarbital overdose treated with supportive care and multidose activated

charcoal

Rachel Wc Ng, Clinical Pharmacology and Toxicology, Western Sydney Local Health District

Toxicology Service, Westmead, Australia.


333 The impact of codeine upscheduling on prescriptions, overdoses, Emergency Department

presentations and mortality in Victoria, Australia

Anselm Wong, Victorian Poisons Information Centre and Austin Toxicology Unit, Austin Health,

Victoria, Australia.


231 Sarolaner-poisoning in an infant: a case report

Angelika Holzer, Poisons Information Centre Austria, Vienna, Austria.


252 Acute kidney failure due to acetaminophen overdose: a case report

Marian Piqueur, Departement of Laboratory Medicine, Ziekenhuis Netwerk Antwerpen, Antwerp,

Belgium.


253 Venlafaxine-associated hypoglycemia: frequency and correlation with symptom severity

Elias Bekka, Department of Clinical Toxicology, Klinikum Rechts der Isar, Technical University of

Munich, Munich, Germany.


254 Hydroxyzine poisoning in the intensive care unit: predictive factors of cardiovascular

complications and toxicokinetics




255 Lamotrigine poisoning in the ICU: a case series with evaluation of the toxicocokinetics and

the predictive value of the plasma concentration on admission




256 Rispiridone poisoning in the intensive care unit: evaluation of the poisoning severity on

admission




37

257 Nicardipine poisoning in the intensive care unit: management, outcome and toxicokinetics




258 Poisonings involving angiotensin-converting enzyme inhibitors in the intensive care unit: a

case series




259 Salicylate poisoning admitted to the intensive care unit: features and toxicokinetics




260 Antidepressant drug poisonings and the risk of thromboembolic complications: a case series

from an intensive care unit

Bruno Mégarbane, Department of Medical and Toxicological Critical Care, Department of Medical

and Toxicological Critical Care, Lariboisière Hospital, Paris-Diderot University, INSERM UMRS-1144,

Paris, France.


263 Combined beta-blocker and beta-agonist drugs overdose: an unusual balance

Andrea Giampreti, Bergamo Poison Control Center, Papa Giovanni XXIII Hospital, BERGAMO, Italy.


264 Characteristics of use and outcome of naloxone administration to non-intensive care and

non-surgical hospitalized adult patients: a pilot study

Ophir Lavon, Clinical Pharmacology and Toxicology Unit, Carmel Medical Center, Haifa, Israel.


266 Medication errors in nursing homes and other residential institutions with full-time staff

attendance: a Danish Poisons Information Centre quality project

Karen R Eriksen, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.


268 Crisis averted? Olanzapine as an antidote for serotonin toxicity: a case report

Erik Lindeman, Swedish Poisons Informatiom Center, Stockholm, Sweden.


269 Non-cardiogenic pulmonary edema in amlodipine poisoning: the lesser evil?

Erik Lindeman, Swedish Poisons Information Center, Stockholm, Sweden.


271 Pharmacobezoar and gastric perforation in severe quetiapine intoxication: a case report





38

273 Intoxication with colchicine: a retrospective study




334 Intravenous iron overdose: don’t trust the blood levels

Ann-Charlott Svanhagen, Swedish Poisons Information Center, Swedish Poisons Information Center,

Stockholm, Sweden.


205 Bedside quantitative electroencephalographic monitoring using the Patient State Index

correlates poorly with Glasgow Coma Score in acutely poisoned patients

Shaun L Greene, Victoria Poisons Information Centre, Austin health, Melbourne, Australia.


335 Favorable acute toxicity profile of the “hiking” stimulant nikethamide

Colette Degrandi, National Poisons Information Centre, Tox Info Suisse, Associated Institute of the

University of Zurich, Zurich, Switzerland.


336 Successful 40-hour delayed acetylcysteine treatment in a severe acetaminophen acute

hepatitis



337 “Reversal” of dabigatran-induced anticoagulation with idarucizumab: experience of an

Italian hospital



338 Metformin-related enquiries from hospitals to the National Poisons Information Service

(NPIS) between 2010-2019: a comparison of metformin only and polypharmacy exposures

Bethan W Hughes, National Poisons Information Service, Cardiff, United Kingdom.


339 Characteristics of emergency department presentations following a drug suicide attempt

Mirjam Kummer, Clinical Pharmacology and Toxicology, Department of General Internal Medicine,

Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.


340 Propylthiouracil administration in 5 cases of thyroid hormone intoxication

Francesca Maida, Pavia Poison Control Centre - National Toxicology Information Centre - Toxicology

Unit, Maugeri Clinical and Scientific Institutes IRCCS and University of Pavia, Pavia, Italy.


341 Evaluation of the overdosage section in Summaries of the Product Characteristics for

medicines responsible for exposure calls to the Belgian Poison Centre

Jonas Moens, Belgian Poison Control Centre, Neder-Over-Heembeek, Belgium.


39

342 Is haem arginate safer in overdose than previously thought? An uneventful four-fold

accidental overdose

Nandesh C Patel, National Poisons Information Service (Birmingham Unit), City Hospital,

Birmingham, United Kingdom.


200 Efficacy of a 12h intravenous acetylcysteine (SNAP) regimen following single acute

paracetamol overdose

Ruben HK Thanacoody, National Poisons Information Service (Newcastle), Newcastle Hospitals NHS

Foundation Trust, Newcastle upon Tyne, United Kingdom.


239 Torsade de pointes following repeated massive loperamide ingestion

Aza Kader, Swedish Poisons Information Centre, Stockholm, Sweden.


247 Using “symptom search” to resolve an unusual case of poisoning reported to the UK National

Poisons Information Service (NPIS)

Ho MR Lee, NPIS (Birmingham Unit), City Hospital, Birmingham, United Kingdom.


249 Different courses of quetiapine poisoning in two patients with gastric decontamination

Anne Stuerzebecher, Poisons Information Centre Erfurt, Erfurt, Germany.


261 Massive polypharmacy overdose resulting in diltiazem pharmacobezoar formation

David Goldberger, Emergency Medicine, Albert Einstein Medical Center, Philadelphia, United States.


232 General characteristics of acute poisonings by hypotensive and antiarrhythmic drugs in

Moscow, 2010-2017

Presented By Anastasia Yu Simonova, Moscow N.V.SklifosovskyResearch Institute of emergency

medical Help, Poisonng teatment Center, Moscow, Russian Federation.


233 Acute toxicity profile of levomepromazine in overdose: a consecutive case series

Stefan Weiler, National Poisons Centre, Tox Info Suisse, Associated Institute of the University of

Zurich, Zurich, Switzerland.


234 Be(a)ware of the fentanyl patch: unusual accidental cases of fentanyl intoxication

Marianne EC Leenders, National Poisons Information Center/Department of Anesthesiology,

University Medical Center, Utrecht, Netherlands.


235 Calls to the Finnish Poison Information Centre related to drug poisoning in older people

Mervi Saukkonen, Poison Information Center, University of Helsinki and Department of Emergency

Medicine and Services, Helsinki University Hospital, Helsinki, Finland.


236 Preliminary experience with plasmapheresis instead of molecular adsorbent recirculating

system as liver support for paracetamol-induced hepatic failure

Philippe Hantson, Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels,

40

Belgium.


237 Acute poisoning with antihypertensive drugs: a retrospective study

Julia V Radenkova-Saeva, Clinic of Toxicology, UMHATEM “N.I.Pirogov”, Sofia, Bulgaria.


238 Rectal overdose of paracetamol



248 Favorable toxicity profile of escitalopram in acute overdose in adults

Katharina M Schenk-Jaeger, National Poisons Information Centre, Tox Info Suisse, Associated

Institute of the University of Zurich, Zurich, Switzerland.


250 The association between phenytoin (diphenylhydantoin) and permanent cerebellar damage

Rachel Day, National Poisons Information Service, Birmingham Centre, Birmingham, United

Kingdom.


343 Literature review of antidotal carbapenem use in valproic acid toxicity

William Rushton, Alabama Poison Information Center, Children's of Alabama, Birmingham, United

States.


Plant and Mushroom Poisoning 077 Beauty can occasionally be toxic: local irritation from a houseplant




087 Kombucha tea: a potential hepatotoxic agent





348 Veratrum Aqua poisonings resulting from its misuse: a case series from Moscow, Russia

Elizaveta V Melnik, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University

(Sechenov University), Moscow, Russian Federation.


071 A 16 year (2002-2017) review of enquiries regarding plant abuse in Austria

Susanna Dorner-Schulmeister, Poisons Information Centre Austria, Vienna, Austria.


072 A 16-year (2002-2017) review of suicide attempts by plant ingestion in Austria

Susanna Dorner-Schulmeister, Poisons Information Centre Austria, Vienna, Austria.


091 Mistaking monkshood for radish resulting in a potentially fatal blood concentration of

aconitine

41

Uwe Stedtler, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany.


092 Intoxication with castor beans

Marine Grigoryan, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.


349 Lethal poisoning with Oenanthe crocata. Survive or not?

Alexis Descatha, PCC, Ester Unit (IRSET U1085), Univ Angers- CHU Angers- Inserm, Angers, France.


070 Suicidal Cerbera odollam poisoning: a case report

Angelika Holzer, Poisons Information Centre Austria, Vienna, Austria.


081 A severe and prolonged case of Amanita phalloides poisoning

Anja J Huusom, Department of Occupational and Environmental Medicine, The Danish Poisons

Information Centre, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.


085 Facial paralysis after cutaneous burns from Heracleum mantegazzianum





088 Does combining vitamin C and vitamin B17 (amygdalin) worsen toxicity?

Faisal S Minhaj, Maryland Poison Center, Baltimore, United States.


089 Confusion between toxic and edible plants registered by the French Poison Control Centres

from 2012 to 2018

Sandra Sinno-Tellier, Health Alerts and Vigilance department, French Agency for Food,

Environmental and Occupational Health & Safety, MAISONS-ALFORT, France.


090 Acute poisoning due to Datura ingestion: case report




093 Severe plant poisonings admitted to the intensive care in France: management and outcome




350 The White Panther: rare exposure to Amanita multisquamosa causing clinically significant

toxicity

Varun Vohra, Emergency Medicine, Michigan Poison Center, Wayne State University School of



42

Toxinology (bites, stings, antivenom etc) 195 Antidote treatment in viper envenomation in Italy: a comparison of 4 antivenoms during a 6

year study





278 The changing pattern of treatment for latrodectism over time in a toxicology unit: red-back

spider antivenom or standard analgesic therapy: nothing to RAVE about

Andis Graudins, Clinical Toxicology Unit, Emergency Medicine Service, Monash Health and Monash

University, Dandenong, Australia.


280 A serious viper bite in a pregnancy

Francesco Gambassi, Toxicology Unit and Poison Control Center, Firenze, Italy.


281 Spider bites in France: a retrospective study using the French Poison Control Centers

Network from 2007 to 2017

Gaël Le Roux, Centre antipoison et Toxicovigilance Grand Ouest, Centre antipoison et

Toxicovigilance Grand Ouest, Angers, France.


283 Recurrent thrombocytopenia after Italian viper bite: a case report



Pavia (Italy), Pavia, Italy, Pavia, Italy.


377 Hyperbaric oxygen therapy in Loxoscelism skin necrosis: a case report


Milan, Italy.


378 Exotic venomous snakebites in Switzerland reported to the National Poisons Information

Centre over 22 years

Joan Fuchs, Tox Info Suisse, University of Zurich, Zurich, Switzerland.


379 Far from home: compartmental syndrome after envenomation by Crotalus atrox in

metropolitan France

Gaël Le Roux, Poison Control Center and Toxicovigilance, Angers, France.


380 Human exposure to larvae of processionary moths in France: study of symptomatic cases

registered by the French Poison Control Centres between 2012 and 2019

Sandra Sinno-Tellier, Health Alerts and Vigilance Department, French Agency for Food,

environmental and Occupational Health & Safety, MAISONS-ALFORT, France.


284 Latrodectus tredecemguttatus poisoning: a case report treated with antidote


43




285 Prolonged neurological effects after delayed antivenin administration

Alfred Aleguas, Poison Information Center-Tampa, Tampa General Hospital, Tampa, United States.


286 Cardiovascular complications following ciguatera fish poisoning in the French West Indies: a

case series

Dabor Resiere, Critical Care Medicine, University Hospital of Martinique, Fort de France,

Martinique.


287 Epidemiology of bites by indigenous venomous snakes in Switzerland reported to Tox Info

Suisse over a 22 year period

Joan Fuchs, Swiss National Poisons Information Center, Tox Info Suisse, Associated Institute of the

University of Zurich, Zurich, Switzerland.


289 An analysis of envenoming features in adder bite cases referred to the UK National Poisons


David Stewart, NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.


290 Kambô: a healing potion or a poisonous toxin?

Annie Watt, NPIS Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.


291 Viper bite neurotoxicity: two pediatric cases in central Italy

Marco Marano, Emergency Department PICU. Regional Pediatric Poison Control Center, Bambino

Gesù Children Hospital, Rome, Italy.


292 Thromboelastogram use in Crotalus adamanteus envenomation

William F Rushton, Office of Medical Toxicology, Department of Emergency Medicine, University of

Alabama at Birmingham, Birmingham, United States.


381 Rattlesnake bite in Austria: a case report

Susanna Dorner-Schulmeister, Poisons Information Centre, Vienna, Austria.


382 Bitten abroad, an unforgettable souvenir: bites and stings reported to the UK National

Poisons Information Service (NPIS) sustained whilst travelling overseas, 2009-2019


Kingdom.


Veterinary toxicology (poisoning in animals) 065 Animal PoisonLine: review of a new public access veterinary poisons information service

Zoe Tizzard, Veterinary Poisons Information Service, London, United Kingdom.


44

066 Flurbiprofen toxicosis in dogs

Nicola Bates, Veterinary Poisons Information Service, London, United Kingdom.


067 A retrospective study of cement exposure in 42 dogs

Nicola Bates, Veterinary Poisons Information Service, London, United Kingdom.


068 Cases of botulism in waterfowls in the Po river valley

Carlo A. Locatelli, Pavia Poison Control Centre - National Toxicology Information Centre, Clinical and




383 Role of decontamination in dogs poisoned by alphachloralose-based rodenticides: a case

series

Marieke A Dijkman, Dutch Poisons Information Center (DPIC), University Medical Center Utrecht,

Utrecht, Netherlands.


384 “Curiosity killed the cat”: cats poisoned by alphachloralose containing rodenticides




385 A case series of hypothermic, sedated cats with sensory-induced CNS excitation:

alphachloralose poisoning?




386 When does xylitol-induced hypoglycaemia occur in dogs?

Nick Edwards, Veterinary Poisons Information Service, London, United Kingdom.


387 The effect of the COVID-19 pandemic on call numbers to the Veterinary Poisons Information

Service (VPIS) and Animal PoisonLine (APL)



388 The effect of the COVID-19 pandemic on animal poisons cases reported to the Veterinary

Poisons Information Service (VPIS) and Animal PoisonLine (APL)



389 The successful treatment of thallium sulfate toxicity in a dog using Prussian blue

Anne Kan, Dutch Poisons Information Center, University Medical Center, Utrecht, Netherlands.


45

Miscellaneous 108 Utilization of the Danish Poisons Information Centre: a nationwide registry study

Tonny S Petersen, Department of Clinical Pharmacology, Bispebjerg Hospital, Copenhagen,

Denmark.


002 A watchful foretaste of Article 45 Annex VIII: things you will wish you knew before

Geert Verstegen, Belgian Poison Centre, Brussels, Belgium.


003 Current experience of the Belgian Poison Centre with the new product notification

requirements implementing article 45

Anne-Marie K Descamps, Belgian Poison Centre, Brussels, Belgium.


179 Human skin explants ex vivo study: lesions caused by topical exposure to 25%

tetramethylammonium hydroxide (TMAH)

Alan H Hall, Medical Toxicology, Toxicology Consulting and Medical Translating Services, Azle,

Texas, United States.


190 Risk assessment and lessons learned: a collaboration between Public Health and a National

Poisons Information Centre

Edel Duggan, National Poisons Information Centre, Dublin, Ireland.


202 Three years of experience implementing a chemical submission protocol at an Emergency

Department

Juan Ortega Pérez, Emergengy Department Hospital Universitari Son Espases, Attending Physician,

Palma de Mallorca, Spain.


178 The role of CYP450 in the molecular toxicology of sulfur mustard in vitro

Presented By Simone Rothmiller, Bundeswehr Institute of Pharmacology and Toxicology, Munich,

Germany.


181 “All right, I’ll be more careful next time”: frequent callers in Finnish Poison Information

Centre (FPIC)

Suvi Pajarre-Sorsa, Poison Information Centre, Poison Information Centre, University of Helsinki and

Department of Emergency Medicine and Services, Helsinki University Hospital, Helsinki, Finland,

Helsinki, Finland.


184 Risky dietary supplements: self-harm with potassium salt capsules

Sonny Larsson, Swedish Poison Information Centre, Solna, Sweden.


188 Supporting the establishment of an Ethiopian Poisons Centre

Ruben Thanacoody, National Poisons Information Service (Newcastle Unit), Newcastle Hospitals

NHS Foundation Trust, Newcastle, United Kingdom.


46

192 Diphtheria: two cases treated with antitoxin





363 Requests regarding snus to the Poisons Information Centre in Austria

Tara Arif, Poisons Information Centre, Vienna, Austria.


364 Multiple treatments of clotrimazole during pregnancy

Sian C D Harbon, National Poisons Information Service, Cardiff, United Kingdom.


365 Challenges facing the UK National Poisons Information Service (NPIS) ahead of EU Exit and

commencement of Annex VIII of Article 45 (Classification, Labelling and Packaging)


Kingdom.


366 When volvulus hides a poisoning: a case of severe foodborne botulism

Roberto Zoppellari, Department of Anaesthesia and Intensive Care, S. Anna Hospital, Ferrara, Italy.


105 Toxicological evaluation of a cluster of reports of hepatitis related to turmeric dietary

supplements in Italy





185 Valproic acid in the management of delirious, agitated critically ill toxicology patients

Joseph J Rasimas, Consultation - Liaison Psychiatry, Hennepin County Medical Center, Minneapolis,

United States.


186 Takotsubo syndrome during benzodiazepine withdrawal: a case report

Francesco Gambassi, Medical Toxicology Unit and Poison Control Center, Azienda Ospedaliero-

Universitaria Careggi, Firenze, Italy.


191 Myocardial infarction in the acutely poisoned patient: a case series




193 QTc interval and electrolyte derangement in alcohol withdrawal-related seizures

Agnesa Mustafa, Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, United

Kingdom.


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