Science for Global Health: Fostering International Collaboration

Norka Ruiz Bravo,PhDSpecial Advisor to the Director

National Institutes of HealthU.S. Department of Health and Human Services

IANAS Science Funding Workshop26-28 July 2009

Outline

•Global Burden of Disease •Biomedical Research Portfolio •NIH Structure, Function •Fogarty International Center

World

31%

59%

10%

Region of the Americas

14%

76%

10%

Communicable, Maternal, Perinatal, and Nutritional Conditions Non-Communicable Diseases Injuries

Source: World Health Report, 2008; Disease Control Priorities Project, 2006

Pop. ~ 6 billion Pop. ~ 874 million

Global Burden of Disease, Reported Mortality by Cause, 2004

Source: World Health Report, 2008; Disease Control Priorities Project, 2006

25%

43%

8%

6%

5%

6%7%

Malignant neoplasms

CardiovasculardiseasesRespiratory diseases

Digestive diseases

Diabetes mellitus

NeuropsychiatricconditionsOther

Global Burden of Disease, Reported Mortality by Cause, Non-Communicable Diseases,

Region of the Americas, 2004

Balanced National Biomedical Research Portfolio

NIH - $30 B

Clinical Research

Basic Research

Translational Research

Private Sector - $60B

Clinical Research

Basic Research

Translational Research

NIH Extramural Grants (FY 2008)

•Supports > 150,000 PIs & Key Personnel

•About 83% of NIH budget

•Awards issued to > 3,000 institutions in > 100 countries

•Clinical, Basic, & Translational Research

National Institutes of Health, Bethesda, Maryland, Research Campus

National Institutes of Health: The Steward of Biomedical and Behavioral

Research for the Nation

MISSION

Science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability.

METHODS Supporting peer-reviewed scientific research at

universities, medical schools, hospitals, and research institutions throughout United States and overseas

Conducting research in its own laboratories Training research investigators Developing and disseminating credible health

information based on scientific discovery

= Institutes and Centers that award grants

Elias Zerhouni, M.D.Director, NIH

Director

National Instituteon Alcohol Abuseand Alcoholism

National Instituteon Alcohol Abuseand Alcoholism

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National CancerInstitute

National CancerInstitute

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Instituteof Dental andCraniofacial

Research

National Instituteon Drug Abuse

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteof Environmental Health Sciences

National Instituteon Aging

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National Instituteof Child Health

and HumanDevelopment

National Institute onDeafness and Other

CommunicationDisorders

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National EyeInstitute

National HumanGenome Research

Institute

National HumanGenome Research

Institute

National Heart,Lung, and Blood

Institute

National Heart,Lung, and Blood

Institute

National Instituteof Mental Health

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof General

Medical Sciences

National Instituteof General

Medical Sciences

National Instituteof Nursing Research

National Instituteof Nursing Research

National Libraryof Medicine

National Libraryof Medicine

Center for InformationTechnology

Center for InformationTechnology

Center for Scientific Review

Center for Scientific Review

National Centerfor Complementary

and AlternativeMedicine

National Centerfor Complementary

and AlternativeMedicine

National Instituteof Allergy and

Infectious Diseases

National Instituteof Allergy and

Infectious Diseases

National Centerfor ResearchResources

National Centerfor ResearchResources

Clinical CenterClinical Center

National Center on Minority Health andHealth Disparities

National Center on Minority Health andHealth Disparities

National Institute of Biomedical Imagingand Bioengineering

National Institute of Biomedical Imagingand Bioengineering

FogartyInternational

Center

FogartyInternational

Center

NIH Budget

$24.7

$4.7

Spending at NIH

Spending Outside

84% Outside NIH> 3,000 Organizations Worldwide

16% Inside NIH $2.9 B Intramural Research (10%)$1.2 B Staff & Buildings (4%)$0.6 B Other (2%)

Total FY 2009 Budget: $30.4 Billion

NIH – Extramural and Other Grant Awards, by Type

• Research Grant Programs• New Investigators Program • Multiple Principal Investigators• Research Supplement Programs • Ruth L. Kirschstein

National Research Service Awards (NRSA) • Research Ethics and Training Grant Programs • NIH Career Development (K) Awards • Small Business Awards • Other Programs

Source: http://grants2.nih.gov/grants/funding/funding_program.htm

Mission

• Address global health challenges through innovative and collaborative research and training programs

• Support and advance the NIH mission through international partnerships

• “Science for Global Health”

• FY 2009 Appropriation $68.7 million

~$50 million in grant awards

• 1/3 Research, 2/3 Research Training

• Awards range $10,000 - $1 million

• Low and Middle Income Countries

• Research Capacity Development and Sustainability

Research and Research Training

Fogarty International Research Collaboration Award (FIRCA)

International Cooperative Biodiversity Groups (ICBG)

Ecology of Infectious Diseases (EID)

International Studies on Health and Economic Development (ISHED)

Int’l Tobacco and Health Research and Capacity Building Program

Global Research Initiative Program for New Foreign Investigators (GRIP)

Stigma and Global Health Research Program

Brain Disorders in the Developing World: Research Across the Lifespan

Extramural Research Grants – 8 Programs

Fogarty International Collaborative Trauma and Injury Research Training

International Clinical, Operational, and Health Services Research Training Awards for HIV/AIDS and Tuberculosis

International Maternal and Child Health Research Training

Fogarty International Clinical Scholars Research Training

Informatics Training for Global Health

International Collaborative Genetics Research Training

International Clinical, Operational, and Health Services Research Training Awards for Malaria

Global Infectious Diseases Research Training

International Research Ethics Education and Career Development

International Centers for Excellence in Clinical Research and Management Training

International Training Program in Environmental and Occupational Health

Global Research Training in Population Health

AIDS International Training and Research

Framework Programs for Global Health

Extramural Training Grants – 14 Programs

Bridge the training gap for clinical, operational and health services research in order to:

Strengthen capacity to conduct clinical, operational, and health services research to measure incidence and prevalence of non-communicable disorders and diseases; characterize disease burdens; and devise, evaluate and implement practical and affordable therapeutic or preventive interventions;

Help LMICs apply current knowledge and new discoveries to clinical and public health practice; and

Support programs at research institutions to both train researchers and to communicate and disseminate knowledge in support of evidence-based policies.

$2.5 million awarded to 12 institutions ($150k each in new awards and $200k each in competing renewals) under previous PA issued in FY 2006

New Program Announcement anticipated

IC Partners: NCCAM, NIA, NIDA, NIDCR, NIMH, NINDS and OD/OD/Office of Dietary Supplements

International Clinical, Operational, and HealthServices Research Training Awards (ICOHRTA) Chronic Diseases: Goals and Objectives

ICOHRTA Chronic Diseases: Current Foreign Research and Training Sites

Peru

Argentina

Brazil

Czech RepublicPoland

Turkey

Ukraine

Bangladesh

China

India

VietnamThailand

• Evidence-based health care

• Maternal & child health and nutrition

• Suicide prevention and mental health

• Nutrition-related chronic disease prevention

• Finances and mental health

• Smoking cessation and substance abuse

• Oral health

• Mental health, developmental disabilities and behavioral disorders

• Community-based interventions to prevent drug use and HIV transmission

Source: http://www.fic.nih.gov/programs/training_grants/icohrta/index.htm

ICOHRTA Chronic: Current Research Training Areas

Thank you for your attention!