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Whether it’s hair color or disease susceptibility, our unique genetic makeup plays a powerful role
in determining who we are and shaping our lives. Our mission is to revolutionize how the world
benefits from genetic information, which will enable people to make more informed decisions
about their health.
Affymetrix GeneChip® technology has been pivotal in many landmark studies, including those
named “Breakthrough of the Year” by Science magazine. Our technology offers the most
complete view of the whole genome—to accelerate the development of diagnostics, help tailor
treatments and ultimately cure the world’s most critical diseases. Affymetrix is committed to
developing innovative products that broaden our view of the human genome.
We are passionate about creating a world where everyone benefits from understanding their
own DNA.
To learn more, visit www.affymetrix.com
From red hair to red blood cells.
©2008 A�ymetrix, Inc.
GE Healthcare
Whatman is now partof GE Healthcare.
The considerable expertise of Whatman in the fields of sample preparation and filtration technologies has earnedthem an outstanding reputation world wide. Whatman has key enabling technologies used in the understanding ofgene and protein functions. Combining the skills of the two companies will enable GE Healthcare to create strongadded value for customers giving unparalleled support to a wide range of research and lab applications.
For more information visit www.gelifesciences.com/whatman
Creating a centre of excellence in separation technology.
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Sample & Assay Technologies
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Say goodbye to manual spin-column preps and gel electrophoresis!
New PureYield™ Plasmid Miniprep yields transfectable
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New PureYield™ Plasmid Miniprep yields transfectable
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New System Answers Needfor Speed, Purity and Yield
©2008 Promega Corporation, 16405-AD-GN
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Looking for the right solution for your high yield PCR? Choose from an expanded selection of
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n LongAmp™ Taq PCR Kit r . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . E5200S
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n Taq 5X Master Mix r . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M0285S/L
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■ Obtain sequencing read lengths of 400 to 500 bases.
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Length Matters
Introducing the GS FLX Titanium Reagents
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Genome Sequencer FLX System
For life science research only. Not for use in diagnostic procedures.
454, 454 LIFE SCIENCES, and 454 SEQUENCING are trademarks of 454 Life Sciences
Corporation, Branford, CT, USA, a Roche company. GS FLX TITANIUM is a trademark of Roche.
Other brands or product names are trademarks of their respective holders.
© 2008 Roche Diagnostics GmbH. All rights reserved.
Roche Diagnostics GmbH
Roche Applied Science
68298 Mannheim, Germany
DNA Sequencing Flowgram: Each bar within the flow-
gram represents a discrete nucleotide (A, T, C, or G) and
the height of the bar corresponds to the number of
nucleotides detected. The flowgram above represents a
458-base-pair sequencing read from E. coli K-12.
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Your local distributor www.eppendorf.com/worldwide · Application Support E-mail: [email protected]
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2009 AAAS Annual Meeting
Our Planet and Its Life: Origins and Futures12–16 February • Chicago
Probe the evolution of emotions, language, morality, and microbes.Join leaders who are tackling the climate change crisis.
Learn how the U.S. elections will affect policy, funding, and you.
Advance registration now openhttp://www.aaas.org/meetings/2009/registration/Get program details at http://www.aaas.org/meetings
President’s AddressJames J. McCarthy, AAAS President; Alexander
Agassiz Professor of Biological Oceanography,
Harvard University, Cambridge, Mass.
Plenary SpeakersSean B. Carroll, Professor of Molecular Biology
and Genetics, University of Wisconsin, Madison
Remarkable Creatures: Epic Adventures in the
Search for the Origins of Species
Susan W. Kieffer, Center for Advanced Study
Professor of Geology and Physics, and Wal-
green University Chair, University of Illinois,
Urbana-Champaign
Celebrating the Earth: Its Past, Our Present,
A Future?
Svante Pääbo, Director of the Department of
Genetics, Max-Planck-Institute for Evolutionary
Anthropology, Leipzig, Germany
A Neanderthal Perspective on Human Origins
Topical LecturesColin F. Camerer, Robert Kirby Professor of
Behavioral Economics, California Institute of
Technology, Pasadena
Interface Between Cognitive Psychology and
Economics
Ekaterina Dadachova, Sylvia and Robert Olnick
Faculty Scholar in Cancer Research, and Associ-
ate Professor of Nuclear Medicine and Microbi-
ology and Immunology, Albert Einstein College
of Medicine of Yeshiva University, Bronx, N.Y.
New Approaches to the Therapy of
Infectious Disease
T. Conrad Gilliam, Marjorie I. and Bernard A.
Mitchell Professor and Chair of the Department
of Human Genetics, University of Chicago, Ill.
Human Genetics
Lene Vestergaard Hau, Mallinckrodt Professor
of Physics and of Applied Physics, Harvard
University, Cambridge, Mass.
Wizardry with Light: Freeze, Teleport, and Go!
Amory Lovins, Co-Founder, Chairman, and
Chief Scientist, Rocky Mountain Institute,
Snowmass, Colo.
Pro�table Solutions to the Oil, Climate, and
Proliferation Problems
Daniel G. Nocera, Professor of Energy and
of Chemistry, Massachusetts Institute of
Technology, Cambridge
Harnessing the Sun and Oceans To Meet the
World’s Energy Demands
Timothy D. White, Professor of Integrative
Biology, University of California, Berkeley
Evolution of Early Humans
Jeanette Wing, Assistant Director, National
Science Foundation, Arlington, Va.
Computational Thinking
Topical Panel: North-South Scienti�c
International Cooperation — Meeting
Global Challenges
Lord Martin Rees, President of the Royal
Society, Master of Trinity College, and
Professor of Cosmology and Astrophysics,
University of Cambridge, U.K.
Jacob Palis, President, Academy of
Sciences for the Developing World,
Rio de Janeiro, Brazil (Invited)
2009 George Sarton Memorial Lecture
Ken Alder, Professor of History and Milton H.
Wilson Professor in the Humanities, Northwest-
ern University, Evanston, Ill.
A History of the International Scienti�c
Conference
2009 John P. McGovern Award Lecture In The
Behavioral Sciences
Elizabeth Loftus, Distinguished Professor,
University of California, Irvine
Illusions and Delusions of Memory
Sean B. Carroll Susan W. Kieffer Svante PääboJames J. McCarthy
fallmeeting
Boston • MA
December 1−5
2008
Meeting ActivitiesSymposia
www.mrs.org/fall2008
2008 MRS FALL MEETING
Electronics, Photonics, and Magnetism
A: Performance and Reliability of Semiconductor Devices
B: Transparent Conductors and Semiconductors for Optoelectronics
C: Theory and Applications of Ferroelectric and Multiferroic Materials
D: Rare-Earth Doping of Advanced Materials for Photonic Applications
E: Materials and Technologies for 3-D Integration
F: Low-Cost Solution-Based Deposition of Inorganic Films for Electronic/Photonic Devices
G: Organic and Hybrid Materials for Large-Area Functional Systems
H: Physics and Technology of Organic Semiconductor Devices
I: Reliability and Properties of Electronic Devices on Flexible Substrates
J: Material Science for Quantum Information Processing Technologies
K: Magnetic Nanostructures by Design
L: New Materials with High Spin Polarization and Their Applications
Energy and the Environment
M: Energy Harvesting—Molecules and Materials
N: Next-Generation and Nano-Architectured Photovoltaics
O: Structure/Property Relationships in Fluorite-Derivative Compounds
P: Photovoltaic Materials and Manufacturing Issues
Q: Scientific Basis for Nuclear Waste Management XXXII
R: Materials for Future Fusion and Fission Technologies
S: Solid-State Ionics
T: Mobile Energy
U: Advanced Intermetallic-Based Alloys for Extreme Environment andEnergy Applications
Engineered Materials and Modeling
V: Materials, Devices, and Characterization for Smart Systems
W: Computational Materials Design via Multiscale Modeling
Y: Biomineral Interfaces—From Experiment to Theory
Z: Mechanics of Biological and Biomedical Materials
AA: Materials for Optical Sensors in Biomedical Applications
BB: Polymer-Based Smart Materials—Process, Properties, and Application
CC: Design, Fabrication, and Self Assembly of “Patchy” and Anisometric Particles
DD: Materials in Tissue Engineering
Nanoscience
EE: Nano- and Microscale Materials—Mechanical Properties andBehavior under Extreme Environments
FF: Nanofunctional Materials, Structures, and Devices for Biomedical Applications
GG: Microelectromechanical Systems—Materials and Devices II
HH: Advances in Material Design for Regenerative Medicine, Drug Delivery, andTargeting/Imaging
II: Bio-inspired Transduction, Fundamentals, and Applications
JJ: Nanotubes, Nanowires, Nanobelts, and Nanocoils—
Promise, Expectations, and Status
KK: Transport Properties in Polymer Nanocomposites
LL: Nanowires—Synthesis, Properties, Assembly, and Application
MM: Applications of Group IV Semiconductor Nanostructures
Synthesis and Characterization
NN: In-situ Studies across Spatial and Temporal Scales for Nanoscienceand Technology
OO: Grazing-Incidence Small-Angle X-Ray Scattering
PP: Solid-State Chemistry of Inorganic Materials VII
QQ: Synthesis and Processing of Organic and Polymeric Functional Materialsfor a Sustainable Energy Economy
RR: Artificially Induced Grain Alignment in Thin Films
SS: Selecting and Qualifying New Materials for Use in Regulated Industries
TT: Local Structure and Dynamics in Amorphous Systems
General Interest
X: Frontiers of Materials Research
Symposium Tutorial Program
Available only to meeting attendees, the
symposium tutorials will concentrate on new,
rapidly breaking areas of research.
Exhibit
A major exhibit encompassing the full
spectrum of equipment, instrumentation,
products, software, publications, and services
is scheduled for December 2-4 in the Hynes
Convention Center. Convenient to the technical
session rooms and scheduled to cmplement the
program, the MRS Fall Exhibit offers everything
you need all under one roof.
Publications Desk
A full display of over 950 books will be available
at the MRS Publications Desk. Symposium
Proceedings from the 2007 MRS Fall Meeting
and 2008 MRS Spring Meeting will be featured.
Student Opportunities
Graduate students planning to attend the 2008
MRS Fall Meeting are encouraged to apply
for a Symposium Assistant position and/or a
Graduate Student Award. Applications will be
acessible on the MRS Web site by June 1.
Career Center
A Career Center for MRS members and
meeting attendees will be open Tuesday
through Thursday.
www.mrs.org/fall2008
For Additional Information,visit the MRS Web site atwww.mrs.org/meetings/
or contact:
Member ServicesMaterials Research Society506 Keystone DriveWarrendale, PA 15086-7573Tel 724-779-3003Fax [email protected]
Meeting Chairs
S. AshokThe Pennsylvania State UniversityTel [email protected]
Shenda M. BakerHarvey Mudd College
Michael R. FitzsimmonsLos Alamos National LaboratoryTel [email protected]
Young-Chang JooSeoul National UniversityTel 82-2-880-8986
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2008 © Invitrogen Corporation. All rights reserved.
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Krista Donaldson, PhD
Mechanical Engineering,Stanford University.
2004-2005 AAAS Fellow atthe U.S. Department ofState, Bureau of NearEastern Affairs, Iraq Desk,Economic Section.
Now a research associate atStanford University’s Centerfor Design Research.
Make a Difference.
Help give science a greater voice inWashington, DC! Since
1973, AAAS Fellows have applied their skills to federal
decision-making processes that affect people in the U.S.
and around the world, while learning first-hand about
the government and policymaking.
Join the Network.
Year-long fellowships are available in the U.S. Congress
and federal agencies. Applicants must hold a PhD or
equivalent doctoral-level degree in any behavioral/social,
biological, medical/health, or physical science, or any
engineering discipline. Individuals with a master’s degree
in engineering and three years of post-degree professional
experience also may apply. Federal employees are not
eligible and U.S. citizenship is required.
Apply.
The application deadline for the 2009-2010 AAAS
Fellowships is 15 December 2008. Fellowships are
awarded in the spring and begin in September.
Stipends range from $68,000 to $90,000.
Note: Additional fellowships are available through
approximately 30 scientific society partners.
Individuals are encouraged to apply with AAAS
as well as with any scientific societies for which
they qualify.
Full details at: fellowships.aaas.org
Picture yourself as a
AAAS Science & Technology
Policy Fellow
Enhancing Public Policy,
Advancing Science Careers
www.sciencemag.org/products SCIENCE VOL 322 17 OCTOBER 2008 465
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New Products Focus: Cell/Tissue Culture
LIFE SCIENCE TECHNOLOGIES
Air Sterilization and Decontamination SystemThe Air Manager system is an air sterilization and decontamination system thatdestroys particulates, resulting in better air control and protection for sensitivelaboratory applications. Rather than relying on filtering out airborne pathogens andparticulates, the system destroys them through a patented sterilization techniquebased on close-coupled field technology (CCFT), in which an electrically generatedplasmafield sterilizes the passing atmosphere. Any particulates in the atmosphere,whether they are viable pathogens, pyrogenic material, chemical fumes, odors,viruses, or other offending materials, are “zapped” by the plasma field as a resultof their own electrical charges. This “zapping” breaks down the chemical bonds ofany materials and reduces the offending particulates, in most cases down to theirelemental constituents. Heavier elemental constituents, which can be harmful, aregenerated by the breakdown of carbon dioxide in the atmosphere and are removedby the combination of the CCFT and the charged exhaust filter bed.
New Products Focus: Cell/Tissue Culture
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizationsare featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products andmaterials. Endorsement by Science or AAAS of any productsor materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
Drug Interaction Study SystemCellport Technologies is a sophisticated assay system that providesthe preclinical in vitro data on drug transporter–mediated drug-druginteractions needed when submitting a new drug application. Theassay makes use of a series of novel cell lines in which transporterexpression has been manipulated in the bidirectional assay format;the assay system clearly determines which efflux transporter(s)a test compound interacts with. The information can be usedto determine whether or not a new drug is safe to use with otherdrugs. The system makes use of Caco-2, a human cell line that hasbeen studied extensively. The cell lines were designed using RNAinterference to knock down specific genes in a stable Caco-2 cellline, one at a time.Absorption SystemsFor information 610-280-7300www.absorption.com
Cell Imaging SystemCellavista is an image-based system that can be used for rapidvisualizationofabroad rangeof cellularassays,while simultaneouslyperforming image analysis. Combining brightfield and fluorescenceoptic capabilities, Cellavista enables users to acquire and analyzeimages for a wide array of cell-based assays, including single-cellcloning, cell confluence, suspension cell count, fluorescence-activated cell sorter seeding efficiency control, cell nuclei count andcharacterization, transfection efficiency, microplate quality control,viral plaque assays, fluorescent protein expression, and apoptosisassays. In as little as five minutes, Cellavista can scan a 96-wellmicroplate with simultaneous image acquisition and analysis. Itfeatures specially designed optics combined with fast auto-focus.Assay-specific analysis algorithms have been developed to identifycell clusters or colonies and are applicable to stem cell research.InnovatisFor information 800-286-1631wwww.innovatis.com/cellavista
Human Epidermal MelanocytesPrimary Clonetics Adult Normal Human Epdidermal Melanocytesare highly characterized cells for use in diverse applications indermal research, including malignant melanoma, dermal disorders,toxicology, pigmentation, and cosmetic studies. Clonetics Adult
Melanocytes are available as cryopreserved amps, proliferatingplates, or proliferating flasks. They are optimized for use with MGM-4 Melanocyte Growth Media BulletKit to deliver outstanding growthand survival in culture.Lonza GroupFor information 800-638-8174www.lonza.com
Neural Stem Cell LinesThe MilliTrace primary rodent neural stem cell lines express greenfluorescentprotein (GFP) constitutively.GFPexpression in thesestemcells is thebestway for researchers tomonitor thebehaviorof specificpopulations of cells as they proliferate, migrate, and differentiateinto various cell lineages, depending on the developmental context.The Millitrace cell lines are the first commercially available, GFP-expressing, karyotypically normal stem cell lines, and are suppliedwith optimized expansion medium. Validated for high levels of GFPexpression, stemcellmarkerexpression, andmultipotency,MilliTraceGFP Reporter Neural Stem Cell Lines can improve reproducibility anddata quality for a variety of applications.MilliporeFor information 800-548-7853www.millipore.com
Stem Cell WorkstationThe SCI-tive (stem cell investigations total in vitro environment)workstation is designed for both embryonic and adult stem cellisolation,optimization,differentiation,and incubationwithina totallyenclosed controlled culture environment. Working under controlledconditions is essential to ensure the cell differentiation process doesnot result in inappropriate cell types. Researchers can monitor theinternal environment of the workstation and control temperature,humidity, and gas concentrations. The workstation features a smallfootprint, and reduces the need for other gas-controlled incubatorsand class 2 biological safety cabinets. All processes can be carriedout within the workstation, with integrated microscopy and digitalsoftwaremaking whole processmonitoring, tracking, and calibrationpossible without disturbing the controlled atmosphere.Ruskinn TechnologyFor information +44-(0)-1656-868540www.ruskinn.com
Scientific Laboratory SuppliesFor information +44-(0)-1159-821-111www.scientific-labs.com
2008 © Invitrogen Corporation. All rights reserved.
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Researchers employed by the not-for-pro�t HudsonAlpha Institute
reside in one wing of the 270,000 square-ft. facility, while a
separate wing houses 12 for-pro�t businesses. The wings are
physically bridged with walkways spanning a soaring atrium that
features inviting common areas. Proximity to the University of
Alabama in Huntsville, the University of Alabama at Birmingham,
Auburn University and Vanderbilt University adds to a rich
intellectual environment for collaboration, discovery and
innovation.
Resumes are currently being accepted for:
genomic research • educational outreach • economic developmentHuntsville, AL • hudsonalpha.org
Richard M. Myers, Ph.D.
Director and Investigator
Jian Han, M.D., Ph.D.
Investigator
Devin M. Absher, Ph.D.
Investigator
Jeremy Schmutz
Investigator
Jane Grimwood, Ph.D.
Investigator
Greg Barsh, M.D., Ph.D.
Visiting Investigator
For descriptions of research areas see hudsonalpha.org/pages/sr-researchareas.html
Current Investigators:Senior Research Scientists
Postdocs
Research Associates and
Assistants
Please send resume and cover letter to:
Dr. Chris Gunter
Director of Research A�airs
